Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DHX58 Gene

Aliases for DHX58 Gene

  • DEXH-Box Helicase 58 2 3
  • DEXH (Asp-Glu-X-His) Box Polypeptide 58 2 3 5
  • Probable ATP-Dependent Helicase LGP2 3 4
  • RIG-I-Like Receptor LGP2 3 4
  • Protein D11Lgp2 Homolog 3 4
  • RIG-I-Like Receptor 3 3 4
  • RNA Helicase LGP2 2 3
  • D11lgp2e 3 4
  • RLR-3 3 4
  • LGP2 3 4
  • RLR 3 4
  • Ortholog Of Mouse D11lgp2 3
  • EC 3.6.4.13 4
  • D11LGP2 3

External Ids for DHX58 Gene

Previous GeneCards Identifiers for DHX58 Gene

  • GC17M037507
  • GC17M040255
  • GC17M036018

Summaries for DHX58 Gene

GeneCards Summary for DHX58 Gene

DHX58 (DEXH-Box Helicase 58) is a Protein Coding gene. Among its related pathways are Immune System and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. GO annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DDX58.

UniProtKB/Swiss-Prot for DHX58 Gene

  • Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5-triphosphorylated RNA, although it can recognize RNA lacking a 5-triphosphate.

Gene Wiki entry for DHX58 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX58 Gene

Genomics for DHX58 Gene

Regulatory Elements for DHX58 Gene

Promoters for DHX58 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DHX58 on UCSC Golden Path with GeneCards custom track

Genomic Location for DHX58 Gene

Chromosome:
17
Start:
42,101,404 bp from pter
End:
42,112,733 bp from pter
Size:
11,330 bases
Orientation:
Minus strand

Genomic View for DHX58 Gene

Genes around DHX58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX58 Gene

Proteins for DHX58 Gene

  • Protein details for DHX58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96C10-DHX58_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DHX58
    Protein Accession:
    Q96C10
    Secondary Accessions:
    • Q9HAM6

    Protein attributes for DHX58 Gene

    Size:
    678 amino acids
    Molecular mass:
    76613 Da
    Quaternary structure:
    • Monomer in the absence of dsRNA. Homodimer in the presence of dsRNA. Interacts with DDX58/RIG-I (via CARD domain), MAVS/IPS1 and DDX60. Found in a complex with DDX58/RIG-I and IFIH1/MDA5. Interacts (via helicase C-terminal domain) with non-structural protein V of Human parainfluenza 2 virus, Human parainfluenza 5 virus, measles virus, mumps virus, hendra virus and nipah virus. Interacts with ANKRD17.

    Three dimensional structures from OCA and Proteopedia for DHX58 Gene

neXtProt entry for DHX58 Gene

Proteomics data for DHX58 Gene at MOPED

Post-translational modifications for DHX58 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHX58 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DHX58 (DHX58)

No data available for DME Specific Peptides for DHX58 Gene

Domains & Families for DHX58 Gene

Gene Families for DHX58 Gene

Protein Domains for DHX58 Gene

Graphical View of Domain Structure for InterPro Entry

Q96C10

UniProtKB/Swiss-Prot:

DHX58_HUMAN :
  • The RLR CTR domain is capable of inhibiting dimerization and signaling of DDX58/RIG-I and also facilitates binding of dsRNA.
  • Belongs to the helicase family. RLR subfamily.
Domain:
  • The RLR CTR domain is capable of inhibiting dimerization and signaling of DDX58/RIG-I and also facilitates binding of dsRNA.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Contains 1 RLR CTR (RLR C-terminal regulatory) domain.
Family:
  • Belongs to the helicase family. RLR subfamily.
genes like me logo Genes that share domains with DHX58: view

Function for DHX58 Gene

Molecular function for DHX58 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5-triphosphorylated RNA, although it can recognize RNA lacking a 5-triphosphate.
UniProtKB/Swiss-Prot Induction:
By interferon (IFN), virus infection, or intracellular dsRNA.

Enzyme Numbers (IUBMB) for DHX58 Gene

Gene Ontology (GO) - Molecular Function for DHX58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005524 ATP binding IEA --
GO:0008270 zinc ion binding IDA 19278996
GO:0016787 hydrolase activity IEA --
GO:0016817 hydrolase activity, acting on acid anhydrides IEA --
genes like me logo Genes that share ontologies with DHX58: view
genes like me logo Genes that share phenotypes with DHX58: view

Animal Models for DHX58 Gene

MGI Knock Outs for DHX58:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DHX58 Gene

Localization for DHX58 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX58 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHX58 Gene COMPARTMENTS Subcellular localization image for DHX58 gene
Compartment Confidence
cytosol 3
nucleus 2
endosome 1
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for DHX58 Gene

Pathways & Interactions for DHX58 Gene

genes like me logo Genes that share pathways with DHX58: view

Pathways by source for DHX58 Gene

Gene Ontology (GO) - Biological Process for DHX58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0009615 response to virus IEA,ISS --
GO:0032480 negative regulation of type I interferon production IEA,IDA 21525357
GO:0032481 positive regulation of type I interferon production IEA,ISS --
GO:0039534 negative regulation of MDA-5 signaling pathway IMP 21187438
genes like me logo Genes that share ontologies with DHX58: view

No data available for SIGNOR curated interactions for DHX58 Gene

Drugs & Compounds for DHX58 Gene

(1) Drugs for DHX58 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DHX58 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DHX58: view

Transcripts for DHX58 Gene

Unigene Clusters for DHX58 Gene

DEXH (Asp-Glu-X-His) box polypeptide 58:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX58 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a ·
SP1: - - -
SP2: - - - - -
SP3: -
SP4:
SP5: - - -
SP6: - - -
SP7: - - - - -
SP8: - -
SP9: - - -

ExUns: 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for DHX58 Gene

GeneLoc Exon Structure for
DHX58
ECgene alternative splicing isoforms for
DHX58

Expression for DHX58 Gene

mRNA expression in normal human tissues for DHX58 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DHX58 Gene

This gene is overexpressed in NK cells (40.6), Breast (13.9), and Testis (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHX58 Gene



SOURCE GeneReport for Unigene cluster for DHX58 Gene Hs.55918

genes like me logo Genes that share expression patterns with DHX58: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DHX58 Gene

Orthologs for DHX58 Gene

This gene was present in the common ancestor of animals.

Orthologs for DHX58 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DHX58 35
  • 85.92 (n)
  • 83.75 (a)
LGP2 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DHX58 35
  • 85.5 (n)
  • 84.66 (a)
DHX58 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dhx58 35
  • 80.04 (n)
  • 78.61 (a)
Dhx58 16
Dhx58 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DHX58 35
  • 99.36 (n)
  • 98.97 (a)
DHX58 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dhx58 35
  • 79.84 (n)
  • 79.2 (a)
oppossum
(Monodelphis domestica)
Mammalia DHX58 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 61 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
chicken
(Gallus gallus)
Aves DHX58 35
  • 62.31 (n)
  • 53.3 (a)
DHX58 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHX58 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx58 35
  • 58.73 (n)
  • 52.41 (a)
zebrafish
(Danio rerio)
Actinopterygii dhx58 35
  • 55.96 (n)
  • 49.7 (a)
dhx58 36
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea drh-1 36
  • 17 (a)
ManyToMany
drh-3 36
  • 14 (a)
ManyToMany
Species with no ortholog for DHX58:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHX58 Gene

ENSEMBL:
Gene Tree for DHX58 (if available)
TreeFam:
Gene Tree for DHX58 (if available)

Paralogs for DHX58 Gene

Paralogs for DHX58 Gene

(3) SIMAP similar genes for DHX58 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DHX58: view

Variants for DHX58 Gene

Sequence variations from dbSNP and Humsavar for DHX58 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2074158 - 42,105,145(-) GATCC(A/G)GAAGT nc-transcript-variant, reference, synonymous-codon, missense
rs2074160 - 42,103,794(-) GATCC(A/G)GGATC intron-variant, reference, missense
rs34891485 - 42,111,440(+) CACGG(C/T)CCAGC nc-transcript-variant, reference, missense
rs35118457 - 42,111,382(+) GGCAC(C/T)GGGCC nc-transcript-variant, reference, missense
rs1557744 -- 42,109,266(-) AGGTA(A/C/T)GCGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHX58 Gene

Variant ID Type Subtype PubMed ID
nsv908240 CNV Loss 21882294
nsv908241 CNV Loss 21882294
dgv3169n71 CNV Loss 21882294

Variation tolerance for DHX58 Gene

Residual Variation Intolerance Score: 79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.30; 76.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHX58 Gene

HapMap Linkage Disequilibrium report
DHX58

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX58 Gene

Disorders for DHX58 Gene

Relevant External Links for DHX58

Genetic Association Database (GAD)
DHX58
Human Genome Epidemiology (HuGE) Navigator
DHX58
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHX58

No disorders were found for DHX58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX58 Gene

Publications for DHX58 Gene

  1. Structure and function of LGP2, a DEX(D/H) helicase that regulates the innate immunity response. (PMID: 18411269) Murali A. … Kao C.C. (J. Biol. Chem. 2008) 3 4 23 67
  2. A shared interface mediates paramyxovirus interference with antiviral RNA helicases MDA5 and LGP2. (PMID: 19403670) Parisien J.P. … Horvath C.M. (J. Virol. 2009) 3 23
  3. Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. (PMID: 16116171) Yoneyama M. … Fujita T. (J. Immunol. 2005) 3 23
  4. The Stat3/5 locus encodes novel endoplasmic reticulum and helicase-like proteins that are preferentially expressed in normal and neoplastic mammary tissue. (PMID: 11735219) Cui Y. … Hennighausen L. (Genomics 2001) 2 3
  5. USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase. (PMID: 24493797) Fan Y. … Yang J. (J. Exp. Med. 2014) 3

Products for DHX58 Gene

Sources for DHX58 Gene

Back to Top

Content