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Aliases for DHX58 Gene

Aliases for DHX58 Gene

  • DExH-Box Helicase 58 2 3 5
  • DEXH (Asp-Glu-X-His) Box Polypeptide 58 2 3
  • Probable ATP-Dependent Helicase LGP2 3 4
  • RIG-I-Like Receptor LGP2 3 4
  • Protein D11Lgp2 Homolog 3 4
  • RIG-I-Like Receptor 3 3 4
  • RNA Helicase LGP2 2 3
  • D11lgp2e 3 4
  • RLR-3 3 4
  • LGP2 3 4
  • RLR 3 4
  • Probable ATP-Dependent RNA Helicase DHX58 3
  • Ortholog Of Mouse D11lgp2 3
  • EC 3.6.4.13 4
  • D11LGP2 3

External Ids for DHX58 Gene

Previous GeneCards Identifiers for DHX58 Gene

  • GC17M037507
  • GC17M040255
  • GC17M036018

Summaries for DHX58 Gene

GeneCards Summary for DHX58 Gene

DHX58 (DExH-Box Helicase 58) is a Protein Coding gene. Among its related pathways are Innate Immune System and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. GO annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is IFIH1.

UniProtKB/Swiss-Prot for DHX58 Gene

  • Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5-triphosphorylated RNA, although it can recognize RNA lacking a 5-triphosphate.

Gene Wiki entry for DHX58 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX58 Gene

Genomics for DHX58 Gene

Regulatory Elements for DHX58 Gene

Enhancers for DHX58 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G042128 1.7 Ensembl ENCODE dbSUPER 36.2 -20.3 -20254 8.4 CREB3L1 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 SSRP1 DHX58 HSPB9 RAB5C KCNH4 HCRT ZNF385C DNAJC7 NKIRAS2 CNP ENSG00000236194
GH17G042115 1.2 ENCODE dbSUPER 36.4 -3.6 -3622 2.6 ELF3 HDAC1 HDGF PKNOX1 FOXA2 ARID4B SIN3A ZBTB40 ZNF2 RAD21 DHX58 CNP KCNH4 HCRT RAB5C AOC4P PIR51780 GC17P042116 KAT2A
GH17G042107 1.2 Ensembl ENCODE 34.9 +4.7 4690 1.7 HDGF GLIS2 SCRT2 CREM ZNF263 SP3 CAVIN1 ZBTB2 CEBPB HDAC8 DHX58 ZNF385C
GH17G042110 0.9 ENCODE 35.5 +0.3 331 3.3 HDGF ARID4B YY1 TCF12 ZNF207 SP3 REST SSRP1 SMARCA4 GLIS1 DHX58 CNP KCNH4 HCRT RAB5C IFI35 AOC4P ZNF385C
GH17G042141 1.3 Ensembl ENCODE dbSUPER 24.2 -29.9 -29866 2.4 TFAP4 FOXA2 SIN3A FEZF1 DNMT3B ZIC2 RARA TEAD3 ZFHX2 POLR2A DHX58 HSPB9 LOC105371781 PIR31172
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DHX58 on UCSC Golden Path with GeneCards custom track

Promoters for DHX58 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000094338 233 601 HDAC1 HDGF TBP ARID4B RAD21 YY1 EGR2 SP3 SMAD5 CBFB

Genomic Location for DHX58 Gene

Chromosome:
17
Start:
42,101,404 bp from pter
End:
42,112,733 bp from pter
Size:
11,330 bases
Orientation:
Minus strand

Genomic View for DHX58 Gene

Genes around DHX58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX58 Gene

Proteins for DHX58 Gene

  • Protein details for DHX58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96C10-DHX58_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DHX58
    Protein Accession:
    Q96C10
    Secondary Accessions:
    • Q9HAM6

    Protein attributes for DHX58 Gene

    Size:
    678 amino acids
    Molecular mass:
    76613 Da
    Quaternary structure:
    • Monomer in the absence of dsRNA. Homodimer in the presence of dsRNA. Interacts with DDX58/RIG-I (via CARD domain), MAVS/IPS1 and DDX60. Found in a complex with DDX58/RIG-I and IFIH1/MDA5. Interacts (via helicase C-terminal domain) with non-structural protein V of Human parainfluenza 2 virus, Human parainfluenza 5 virus, measles virus, mumps virus, hendra virus and nipah virus. Interacts with ANKRD17.

    Three dimensional structures from OCA and Proteopedia for DHX58 Gene

neXtProt entry for DHX58 Gene

Post-translational modifications for DHX58 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHX58 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DHX58 (DHX58)

No data available for DME Specific Peptides for DHX58 Gene

Domains & Families for DHX58 Gene

Gene Families for DHX58 Gene

Protein Domains for DHX58 Gene

Graphical View of Domain Structure for InterPro Entry

Q96C10

UniProtKB/Swiss-Prot:

DHX58_HUMAN :
  • The RLR CTR domain is capable of inhibiting dimerization and signaling of DDX58/RIG-I and also facilitates binding of dsRNA.
  • Belongs to the helicase family. RLR subfamily.
Domain:
  • The RLR CTR domain is capable of inhibiting dimerization and signaling of DDX58/RIG-I and also facilitates binding of dsRNA.
Family:
  • Belongs to the helicase family. RLR subfamily.
genes like me logo Genes that share domains with DHX58: view

Function for DHX58 Gene

Molecular function for DHX58 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5-triphosphorylated RNA, although it can recognize RNA lacking a 5-triphosphate.
UniProtKB/Swiss-Prot Induction:
By interferon (IFN), virus infection, or intracellular dsRNA.

Enzyme Numbers (IUBMB) for DHX58 Gene

Gene Ontology (GO) - Molecular Function for DHX58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA --
GO:0003725 double-stranded RNA binding IDA 18411269
GO:0003727 single-stranded RNA binding IDA 18411269
GO:0004386 helicase activity IEA --
genes like me logo Genes that share ontologies with DHX58: view
genes like me logo Genes that share phenotypes with DHX58: view

Animal Models for DHX58 Gene

MGI Knock Outs for DHX58:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DHX58

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DHX58 Gene

Localization for DHX58 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX58 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHX58 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1
endosome 1

Gene Ontology (GO) - Cellular Components for DHX58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DHX58: view

Pathways & Interactions for DHX58 Gene

genes like me logo Genes that share pathways with DHX58: view

Pathways by source for DHX58 Gene

1 Cell Signaling Technology pathway for DHX58 Gene
1 BioSystems pathway for DHX58 Gene

Gene Ontology (GO) - Biological Process for DHX58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0009615 response to virus ISS --
GO:0016032 viral process IEA --
GO:0032480 negative regulation of type I interferon production IDA 21525357
GO:0032481 positive regulation of type I interferon production ISS --
genes like me logo Genes that share ontologies with DHX58: view

No data available for SIGNOR curated interactions for DHX58 Gene

Drugs & Compounds for DHX58 Gene

(3) Drugs for DHX58 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for DHX58 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DHX58: view

Transcripts for DHX58 Gene

Unigene Clusters for DHX58 Gene

DEXH (Asp-Glu-X-His) box polypeptide 58:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DHX58

Alternative Splicing Database (ASD) splice patterns (SP) for DHX58 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a ·
SP1: - - -
SP2: - - - - -
SP3: -
SP4:
SP5: - - -
SP6: - - -
SP7: - - - - -
SP8: - -
SP9: - - -

ExUns: 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for DHX58 Gene

GeneLoc Exon Structure for
DHX58
ECgene alternative splicing isoforms for
DHX58

Expression for DHX58 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHX58 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DHX58 Gene

This gene is overexpressed in NK cells (40.6), Breast (13.9), and Testis (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DHX58 Gene



NURSA nuclear receptor signaling pathways regulating expression of DHX58 Gene:

DHX58

SOURCE GeneReport for Unigene cluster for DHX58 Gene:

Hs.55918

Evidence on tissue expression from TISSUES for DHX58 Gene

  • Intestine(4.3)
  • Spleen(2.4)
  • Nervous system(2.2)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with DHX58: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHX58 Gene

Orthologs for DHX58 Gene

This gene was present in the common ancestor of animals.

Orthologs for DHX58 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHX58 34 35
  • 99.36 (n)
cow
(Bos Taurus)
Mammalia DHX58 34
  • 85.92 (n)
LGP2 35
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DHX58 34 35
  • 85.5 (n)
mouse
(Mus musculus)
Mammalia Dhx58 34 16 35
  • 80.04 (n)
rat
(Rattus norvegicus)
Mammalia Dhx58 34
  • 79.84 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 72 (a)
OneToMany
-- 35
  • 61 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia DHX58 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves DHX58 34 35
  • 62.31 (n)
lizard
(Anolis carolinensis)
Reptilia DHX58 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx58 34
  • 58.73 (n)
zebrafish
(Danio rerio)
Actinopterygii dhx58 34 35
  • 55.96 (n)
worm
(Caenorhabditis elegans)
Secernentea drh-1 35
  • 17 (a)
ManyToMany
drh-3 35
  • 14 (a)
ManyToMany
Species where no ortholog for DHX58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHX58 Gene

ENSEMBL:
Gene Tree for DHX58 (if available)
TreeFam:
Gene Tree for DHX58 (if available)

Paralogs for DHX58 Gene

Paralogs for DHX58 Gene

(3) SIMAP similar genes for DHX58 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DHX58: view

Variants for DHX58 Gene

Sequence variations from dbSNP and Humsavar for DHX58 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000107731 -- 42,109,646(+) ATCCC(A/G)GCACT intron-variant
rs1000173934 -- 42,106,650(+) AAAAA(A/T)TTAGC intron-variant
rs1000435390 -- 42,106,424(+) TAGGC(A/G)TGCAG intron-variant
rs1000765004 -- 42,104,836(+) CCAGC(A/G)CCTCG nc-transcript-variant, reference, missense
rs1000784105 -- 42,112,523(+) GGGGG(C/G)GGGAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DHX58 Gene

Variant ID Type Subtype PubMed ID
nsv1056904 CNV gain 25217958
nsv1146669 OTHER inversion 26484159

Variation tolerance for DHX58 Gene

Residual Variation Intolerance Score: 79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.30; 76.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHX58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DHX58

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX58 Gene

Disorders for DHX58 Gene

Relevant External Links for DHX58

Genetic Association Database (GAD)
DHX58
Human Genome Epidemiology (HuGE) Navigator
DHX58
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHX58

No disorders were found for DHX58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX58 Gene

Publications for DHX58 Gene

  1. A shared interface mediates paramyxovirus interference with antiviral RNA helicases MDA5 and LGP2. (PMID: 19403670) Parisien J.P. … Horvath C.M. (J. Virol. 2009) 3 4 22 64
  2. Structure and function of LGP2, a DEX(D/H) helicase that regulates the innate immunity response. (PMID: 18411269) Murali A. … Kao C.C. (J. Biol. Chem. 2008) 3 4 22 64
  3. Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. (PMID: 16116171) Yoneyama M. … Fujita T. (J. Immunol. 2005) 3 4 22 64
  4. Ambivalent role of the innate immune response in rabies virus pathogenesis. (PMID: 21525357) Chopy D. … Lafon M. (J. Virol. 2011) 3 4 64
  5. DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling. (PMID: 21791617) Miyashita M. … Seya T. (Mol. Cell. Biol. 2011) 3 4 64

Products for DHX58 Gene

  • Addgene plasmids for DHX58

Sources for DHX58 Gene

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