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DHX58 Gene

protein-coding   GIFtS: 59
GCID: GC17M040255

DEXH (Asp-Glu-X-His) Box Polypeptide 58

  Search for DHX58
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEXH (Asp-Glu-X-His) Box Polypeptide 581 2     RIG-I-Like Receptor LGP22 3
LGP22 3 5     D11LGP22 5
RNA Helicase LGP21 2     D11lgp2e2
Probable ATP-Dependent Helicase LGP22 3     Ortholog Of Mouse D11lgp22
Protein D11Lgp2 Homolog2 3     Probable ATP-Dependent RNA Helicase DHX582
RLR2 3     D11LGP2E3
RLR-32 3     EC 3.6.4.133
RIG-I-Like Receptor 32 3     

External Ids:    HGNC: 295171   Entrez Gene: 791322   Ensembl: ENSG000001087717   OMIM: 6085885   UniProtKB: Q96C103   

Export aliases for DHX58 gene to outside databases

Previous GC identifers: GC17M037507 GC17M036018


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DHX58 Gene:
DHX58 (DEXH (Asp-Glu-X-His) box polypeptide 58) is a protein-coding gene. GO annotations related to this gene include single-stranded RNA binding and helicase activity. An important paralog of this gene is IFIH1.

UniProtKB/Swiss-Prot: DHX58_HUMAN, Q96C10
Function: Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate
antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can
have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this
role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus
or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms:
competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization
and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of
interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping
nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the
innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial
pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a
preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate

Gene Wiki entry for DHX58 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DHX58 gene promoter:
         ER-alpha   STAT1   STAT4   STAT6   STAT1beta   STAT5A   Egr-4   STAT1alpha   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDHX58 promoter sequence
   Search Chromatin IP Primers for DHX58

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DHX58


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

DHX58 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHX58 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M040255:  view genomic region     (about GC identifiers)

Start:
40,253,422 bp from pter      End:
40,264,751 bp from pter
Size:
11,330 bases      Orientation:
minus strand

1 alternative location:
Chr17-,NW_003571052 388,046-399,375     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DHX58_HUMAN, Q96C10 (See protein sequence)
Recommended Name: Probable ATP-dependent RNA helicase DHX58  
Size: 678 amino acids; 76613 Da
Cofactor: Zinc
Subunit: Monomer in the absence of dsRNA. Homodimer in the presence of dsRNA. Interacts with DDX58/RIG-I (via CARD
domain), MAVS/IPS1 and DDX60. Found in a complex with DDX58/RIG-I and IFIH1/MDA5. Interacts (via helicase
C-terminal domain) with non-structural protein V of Human parainfluenza 2 virus, Human parainfluenza 5 virus,
measles virus, mumps virus, hendra virus and nipah virus
3 PDB 3D structures from and Proteopedia for DHX58:
2RQA (3D)        2W4R (3D)        3EQT (3D)    
Secondary accessions: Q9HAM6

Explore the universe of human proteins at neXtProt for DHX58: NX_Q96C10

Explore proteomics data for DHX58 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DHX58 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_077024.2  
    ENSEMBL proteins: 
     ENSP00000467470   ENSP00000251642   ENSP00000416389   ENSP00000466721   ENSP00000404639  
    Reactome Protein details: Q96C10

    DHX58 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals DHX58 Proteins
    Novus Biologicals DHX58 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DHX58

     
    Search eBioscience for Proteins for DHX58 

    DHX58 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of DHX58
    Browse R&D Systems for Antibodies
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    Novus Biologicals DHX58 Antibodies
    Abcam antibodies for DHX58
    Cloud-Clone Corp. Antibodies for DHX58
    ThermoFisher Antibodies for DHX58
    LSBio Antibodies in human, mouse, rat for DHX58

    DHX58 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DHX58
    Cloud-Clone Corp. CLIAs for DHX58
    Search eBioscience for ELISAs for DHX58 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR006935 Helicase/UvrB_dom
     IPR027417 P-loop_NTPase
     IPR021673 RIG-I_C-RD
     IPR014001 Helicase_ATP-bd
     IPR001650 Helicase_C

    Graphical View of Domain Structure for InterPro Entry Q96C10

    ProtoNet protein and cluster: Q96C10

    UniProtKB/Swiss-Prot: DHX58_HUMAN, Q96C10
    Domain: The repressor domain is capable of inhibiting dimerization and signaling of DDX58/RIG-I and also
    facilitates binding of dsRNA
    Similarity: Belongs to the helicase family. RLR subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Find genes that share domains with DHX58           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DHX58_HUMAN, Q96C10
    Function: Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate
    antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can
    have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this
    role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus
    or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms:
    competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization
    and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of
    interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping
    nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the
    innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial
    pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a
    preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate
    Catalytic activity: ATP + H(2)O = ADP + phosphate
    Induction: By interferon (IFN), virus infection, or intracellular dsRNA

         Enzyme Number (IUBMB): EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003725double-stranded RNA binding IDA18411269
    GO:0003727single-stranded RNA binding IDA18411269
    GO:0004386helicase activity IEA--
         
    Find genes that share ontologies with DHX58           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DHX58:
     Increased gamma-H2AX phosphory  Synthetic lethal with c-Myc af 

         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Dhx58):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     reproductive system 

    Find genes that share phenotypes with DHX58           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for DHX58: Dhx58tm1Itl Dhx58tm1Aki Dhx58tm1Gnb

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DHX58
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DHX58

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DHX58
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DHX58

    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate DHX58:
    hsa-miR-509-5p hsa-miR-616* hsa-miR-509-3-5p hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidDHX58 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat DHX58

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: DHX58 (NM_024119)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHX58
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX58
    Addgene plasmids for DHX58 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX58


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DHX58_HUMAN, Q96C10: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with DHX58           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DHX58 About    
    See pathways by source

    SuperPathContained pathways About
    1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    RIG-I-like receptor signaling pathway0.47


    Find genes that share SuperPaths with DHX58           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for DHX58
        RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways


    1 Kegg Pathway  (Kegg details for DHX58):
        RIG-I-like receptor signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including DHX58: 
              Antiviral Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DHX58

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DHX58 (Q96C101, 2, 3 ENSP000002516424) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AP2B1P630102, 3, ENSP000003144144MINT-66465 I2D: score=5 STRING: ENSP00000314414
    DHX30Q7L2E31, 3, ENSP000003926014EBI-744193,EBI-1211456 I2D: score=1 STRING: ENSP00000392601
    NKRFO152261, 3, ENSP000003048034EBI-744193,EBI-766011 I2D: score=1 STRING: ENSP00000304803
    EIF6P565371, 3, ENSP000003635594EBI-744193,EBI-372243 I2D: score=1 STRING: ENSP00000363559
    DICER1Q9UPY31, 3, ENSP000003437454EBI-744193,EBI-395506 I2D: score=1 STRING: ENSP00000343745
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009615response to virus ISS--
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----
    GO:0032480negative regulation of type I interferon production IDA--
    GO:0032481positive regulation of type I interferon production ISS--

    Find genes that share ontologies with DHX58           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DHX58



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DHX58 gene: 
    NM_024119.2  

    Unigene Cluster for DHX58:

    DEXH (Asp-Glu-X-His) box polypeptide 58
    Hs.55918  [show with all ESTs]
    Unigene Representative Sequence: NM_024119
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589979 ENST00000251642(uc002hyv.3 uc002hyw.3 uc010wgf.1)
    ENST00000592024 ENST00000586522 ENST00000590637 ENST00000413196 ENST00000591220
    ENST00000430773
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate DHX58:
    hsa-miR-509-5p hsa-miR-616* hsa-miR-509-3-5p hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidDHX58 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: DHX58 (NM_024119)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX58
    Addgene plasmids for DHX58 
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      QuantiTect SYBR Green Assays in human, mouse, rat DHX58
      QuantiFast Probe-based Assays in human, mouse, rat DHX58

    Additional mRNA sequence: 

    AK021416.1 AK097669.1 AK225549.1 AK296840.1 AK300900.1 BC014949.1 

    7 DOTS entries:

    DT.412079  DT.99939117  DT.120989712  DT.92420835  DT.40294593  DT.92420836  DT.95083394 

    Selected AceView cDNA sequences (see all 92):

    CA425767 AW297288 CA433461 CD364627 AA639536 BM723672 BP359206 BM015460 
    CD367249 CN480868 AI648709 AK097669 BF445484 BC014949 CB529246 CA422663 
    CB851645 AI809227 BX507061 BQ961842 CA418860 BG821972 BQ003648 BI908618 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DHX58 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a ·
    SP1:              -     -     -                                                                                                                                 
    SP2:                                                        -     -     -     -                                                                 -               
    SP3:                                                                                                                          -                                 
    SP4:                                                                                                                                                            
    SP5:              -     -     -                                                                                                                                 

    ExUns: 15b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for DHX58

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DHX58 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCTGGAGA
    DHX58 Expression
    About this image


    DHX58 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Thymus (Hematopoietic System)
     
     Testis (Reproductive System)
    DHX58 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DHX58 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.55918
        Pathway & Disease-focused RT2 Profiler PCR Array including DHX58: 
              Antiviral Response in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for DHX58
    OriGene qSTAR qPCR primer pairs in human, mouse for DHX58
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DHX58
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    QuantiFast Probe-based Assays in human, mouse, rat DHX58
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX58

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DHX58 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dhx581 , 5 DEXH (Asp-Glu-X-His) box polypeptide 581, 5 80.04(n)1
    78.61(a)1
      11 (63.52 cM)5
    808611  NM_030150.21  NP_084426.21 
     1006948845 
    chicken
    (Gallus gallus)
    Aves DHX581 DEXH (Asp-Glu-X-His) box polypeptide 58 62.31(n)
    53.3(a)
      100858653  XM_003642831.2  XP_003642879.1 
    lizard
    (Anolis carolinensis)
    Reptilia DHX586
    DEXH (Asp-Glu-X-His) box polypeptide 58
    55(a)
    1 ↔ 1
    5(10218894-10232711)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dhx581 DEXH (Asp-Glu-X-His) box polypeptide 58 58.73(n)
    52.41(a)
      100492559  XM_002939041.2  XP_002939087.2 
    zebrafish
    (Danio rerio)
    Actinopterygii dhx581 DEXH (Asp-Glu-X-His) box polypeptide 58 55.96(n)
    49.7(a)
      100148871  NM_001257157.1  NP_001244086.1 
    worm
    (Caenorhabditis elegans)
    Secernentea drh-16
    drh-36
    Protein DRH-3 (drh-3) mRNA, complete cds
    17(a)
    14(a)
    many ↔ many
    many ↔ many
    IV(6607377-6613353) WBGene00001090
    I(7820843-7826380) WBGene00008400


    ENSEMBL Gene Tree for DHX58 (if available)
    TreeFam Gene Tree for DHX58 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DHX58 gene
    IFIH12  DICER12  DDX582  
    3 SIMAP similar genes for DHX58 using alignment to 5 protein entries:     DHX58_HUMAN (see all proteins):
    IFIH1    MDA5    DDX58

    Find genes that share paralogs with DHX58           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DHX58 (see all 382)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs585105101,2
    C--36027300(+) AAAAA-/A/AA  
            
    GAAAA
    1 -- int11NA 2
    rs118697761,2
    C,F,H--40253096(+) ggcagG/Tcagat 1 -- ds50013Minor allele frequency- T:0.50NA 8
    rs1444388581,2
    --40253103(+) AGATCA/GCCTGA 1 -- ds50010--------
    rs1484129521,2
    --40253193(+) GTGGCA/GGGCAC 1 -- ds50010--------
    rs1914799361,2
    --40253343(+) ATTTTA/TAAAAA 1 -- ds50010--------
    rs1117769681,2
    C--40253565(+) ATATGC/AAAATG 1 -- ut311Minor allele frequency- A:0.50CSA 2
    rs1831344091,2
    --40253649(+) CAGGGG/TGCCCA 1 -- ut310--------
    rs2004818351,2
    --40253738(+) CTCCCA/GCCCCC 1 -- ut310--------
    rs1423600071,2
    C--40253808(+) GTTCTC/TGGCAC 2 K E mis10--------
    rs1459548491,2
    C--40253809(+) TTCTCG/AGCACA 2 /A syn11Minor allele frequency- A:0.00NA 4528

    HapMap Linkage Disequilibrium report for DHX58 (40253422 - 40264751 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DHX58:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3169n71CNV Loss21882294
    nsv908241CNV Loss21882294
    nsv908240CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DHX58
    DNA2.0 Custom Variant and Variant Library Synthesis for DHX58

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608588    OMIM disorders: --


    Find genes that share disorders with DHX58           About GenesLikeMe

    Genetic Association Database (GAD): DHX58
    Human Genome Epidemiology (HuGE) Navigator: DHX58 (1 document)

    Export disorders for DHX58 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DHX58 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with DHX58)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and function of LGP2, a DEX(D/H) helicase that regulates the innate immunity response. (PubMed id 18411269)1, 2, 9 Murali A.... Kao C.C. (J. Biol. Chem. 2008)
    2. A shared interface mediates paramyxovirus interference with antiviral RNA helicases MDA5 and LGP2. (PubMed id 19403670)1, 2, 9 Parisien J.P.... Horvath C.M. (J. Virol. 2009)
    3. Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. (PubMed id 16116171)1, 2, 9 Yoneyama M.... Fujita T. (J. Immunol. 2005)
    4. Ambivalent role of the innate immune response in rabies virus pathogenesis. (PubMed id 21525357)1, 2 Chopy D....Lafon M. (J. Virol. 2011)
    5. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    6. The RIG-I-like receptor LGP2 recognizes the termini of double- stranded RNA. (PubMed id 19278996)1, 2 Li X.... Li P. (J. Biol. Chem. 2009)
    7. Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. (PubMed id 17190814)1, 2 Saito T.... Gale M. Jr. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    8. RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2. (PubMed id 17020950)1, 2 Komuro A. and Horvath C.M. (J. Virol. 2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The Stat3/5 locus encodes novel endoplasmic reticulum and helicase-like proteins that are preferentially expressed in normal and neoplastic mammary tissue. (PubMed id 11735219)1, 3 Cui Y....Hennighausen L. (Genomics 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79132 HGNC: 29517 AceView: LGP2 Ensembl:ENSG00000108771 euGenes: HUgn79132
    ECgene: DHX58 Kegg: 79132 H-InvDB: DHX58

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DHX58 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DHX58 gene:
    Search GeneIP for patents involving DHX58

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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