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Set Analyses:

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DHX57 Gene

protein-coding GIFtS: 53
GCID: GC02M039025

DEAH (Asp-Glu-Ala-Asp/His) Box Polypeptide 57

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
DEAH (Asp-Glu-Ala-Asp/His) Box Polypeptide 57¹ ²		Putative ATP-Dependent RNA Helicase DHX57²
DEAH Box Protein 57² ³		EC 3.6.4.13³
DDX57²		EC 3.6.1⁸
DEAH-Box RNA/DNA Helicase AAM73547²

External Ids:	HGNC: 20086¹	Entrez Gene: 90957²	Ensembl: ENSG00000163214⁷	UniProtKB: Q6P158³

Export aliases for DHX57 gene to outside databases

Previous GC identifers: GC02M038982 GC02M038999 GC02M038936 GC02M038878 GC02M038763

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DHX57 Gene:

DHX57 (DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57) is a protein-coding gene. Diseases associated with DHX57 include obesity, and cerebritis. GO annotations related to this gene include ATP-dependent helicase activity and nucleic acid binding. An important paralog of this gene is DHX29.

UniProtKB/Swiss-Prot: DHX57_HUMAN, Q6P158

Function: Probable ATP-binding RNA helicase

Gene Wiki entry for DHX57 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000002.12 NC_018913.2 NT_022184.16

Regulatory elements:

Regulatory transcription factor binding sites in the DHX57 gene promoter:
E2F-3a E2F-4 C/EBPbeta E2F-5 E2F-2 CUTL1 Evi-1 Pax-3 E2F-1 E2F
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DHX57 promoter sequence

Search Chromatin IP Primers for DHX57

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DHX57

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.1 Ensembl cytogenetic band: 2p22.1 HGNC cytogenetic band: 2p22.3

DHX57 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHX57 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M039025: view genomic region (about GC identifiers)

Start:	39,024,871 bp from pter	End:	39,103,075 bp from pter
Size:	78,205 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DHX57_HUMAN, Q6P158 (See protein sequence)

Recommended Name: Putative ATP-dependent RNA helicase DHX57

Size: 1386 amino acids; 155604 Da

Sequence caution: Sequence=AAM73547.1; Type=Erroneous initiation; Sequence=AAY24256.1; Type=Erroneous gene model

prediction;

Secondary accessions: A2RRC7 Q53SI4 Q6P9G1 Q7Z6H3 Q8NG17 Q96M33

Alternative splicing: 3 isoforms: Q6P158-1 Q6P158-2 Q6P158-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DHX57: NX_Q6P158

Explore proteomics data for DHX57 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

Selected DME Specific Peptides for DHX57 (Q6P158) (see all 7)

TNIAETS

AETSITI

VDEVHER

VILMSAT

See DHX57 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_945314.1

ENSEMBL proteins:

ENSP00000295373 ENSP00000397841 ENSP00000405111 ENSP00000387404 ENSP00000400702

DHX57 Human Recombinant Protein Products:

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DHX57 Assay Products:

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	Cloud-Clone Corp. ELISAs for DHX57 Cloud-Clone Corp. CLIAs for DHX57

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

DHX: DEAH-boxes

Selected InterPro protein domains (see all 11):

IPR000571 Znf_CCCH

IPR011545 DNA/RNA_helicase_DEAD/DEAH_N

IPR002464 DNA/RNA_helicase_DEAH_CS

IPR009060 UBA-like

IPR006575 RWD-domain

Graphical View of Domain Structure for InterPro Entry Q6P158

ProtoNet protein and cluster: Q6P158

4 Blocks protein domains:

IPB000571 Zn-finger

IPB002464 ATP-dependent helicase

IPB006575 RWD

IPB007502 Helicase-associated region

UniProtKB/Swiss-Prot: DHX57_HUMAN, Q6P158

Similarity: Belongs to the DEAD box helicase family. DEAH subfamily

Similarity: Contains 1 C3H1-type zinc finger

Similarity: Contains 1 helicase ATP-binding domain

Similarity: Contains 1 helicase C-terminal domain

Similarity: Contains 1 UBA domain

DHX57 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: DHX57_HUMAN, Q6P158

Function: Probable ATP-binding RNA helicase

Catalytic activity: ATP + H(2)O = ADP + phosphate

Enzyme Numbers (IUBMB): EC 3.6.1² EC 3.6.4.13¹

Gene Ontology (GO): Selected molecular function terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0004386	helicase activity	--	--
GO:0005515	protein binding	--	--
GO:0005524	ATP binding	IEA	--
GO:0008026	ATP-dependent helicase activity	IEA	--

DHX57 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DHX57

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DHX57

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DHX57

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DHX57

miRNA Products:		miRTarBase miRNAs that target DHX57: hsa-let-7b-5p (MIRT001639), hsa-mir-590-3p (MIRT016202), hsa-mir-23b-3p (MIRT023464), hsa-let-7a-5p (MIRT052544), hsa-let-7e-5p (MIRT051546), hsa-mir-744-5p (MIRT037449), hsa-mir-15a-3p (MIRT038983), hsa-let-7d-5p (MIRT051721), hsa-mir-98-5p (MIRT027741), hsa-mir-125b-5p (MIRT045910), hsa-mir-877-3p (MIRT037095)

		Block miRNA regulation of human, mouse, rat DHX57 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate DHX57 (see all 18):
		hsa-miR-181c hsa-let-7d hsa-let-7c hsa-miR-218 hsa-let-7g hsa-miR-320e hsa-let-7a hsa-miR-3662

		SwitchGear 3'UTR luciferase reporter plasmid: DHX57 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX57

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	3
cytoskeleton	1
cytosol	1

About this image

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for DHX57
Interactions:

Search GeneGlobe Interaction Network for DHX57

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for DHX57 (Q6P158^{2, 3} ENSP00000295373⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 124)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DDX56	Q9NY93³, ENSP00000258772⁴	I2D: score=2 STRING: ENSP00000258772
LYAR	Q9NX58³, ENSP00000345917⁴	I2D: score=2 STRING: ENSP00000345917
DDX21	Q9NR30², ENSP00000346120⁴	MINT-8395092 STRING: ENSP00000346120
NAT10	Q9H0A0², ENSP00000257829⁴	MINT-8395092 STRING: ENSP00000257829
GABARAP	O95166³	I2D: score=1

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for DHX57

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for DHX57 gene:

NM_198963.1

Unigene Cluster for DHX57:

DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57

Hs.468226 [show with all ESTs]

Unigene Representative Sequence: BC153875

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000295373(uc002rre.3 uc002rrf.3) ENST00000452978 ENST00000460193(uc002rrd.4)

ENST00000457308 ENST00000477981 ENST00000497514 ENST00000442331 ENST00000474104(uc002rrg.3)

ENST00000492042 ENST00000479345 ENST00000417233

miRNA Products:		Block miRNA regulation of human, mouse, rat DHX57 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate DHX57 (see all 18):
		hsa-miR-181c hsa-let-7d hsa-let-7c hsa-miR-218 hsa-let-7g hsa-miR-320e hsa-let-7a hsa-miR-3662

		SwitchGear 3'UTR luciferase reporter plasmid: DHX57 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for DHX57
		Predesigned siRNA for gene silencing in human, mouse, rat DHX57

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		GenScript: all cDNA clones in your preferred vector: DHX57 (NM_198963)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHX57
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX57

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for DHX57
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat DHX57
		QuantiTect SYBR Green Assays in human, mouse, rat DHX57
		QuantiFast Probe-based Assays in human, mouse, rat DHX57

Additional mRNA sequence:

AB209249.1 AF070590.1 AF283512.1 AK057423.1 AK296739.1 AK307514.1 BC012454.1 BC033636.1

BC039270.1 BC053623.1 BC060778.1 BC065278.1 BC131534.1 BC153875.1

10 DOTS entries:

DT.441867 DT.303178 DT.442758 DT.101975844 DT.40117842 DT.110310 DT.92418889 DT.120931050

DT.120931024 DT.92418888

Selected AceView cDNA sequences (see all 110):

AI125363 AI203420 AA099678 CR620209 BU183594 BF970974 AA278968 AA431613

NM_198963 AI204143 BM352293 BQ719095 BF739883 BX102332 BC065278 AF070590

NM_145646 BU189567 AA343694 BC053623 BE219229 AK057423 AA236829 AI453361

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for DHX57 (see all 7) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	^	10a	·	10b	·	10c	^	11a	·	11b	^	12	^	13	^	14	^	15	^	16	^	17	^
SP1:																									-												-
SP2:																									-						-						-
SP3:																									-						-
SP4:
SP5:					-		-

ExUns:	18	^	19	^	20	^	21	^	22	^	23	^	24	^	25	^	26a	·	26b
SP1:
SP2:
SP3:													-
SP4:
SP5:

ECgene alternative splicing isoforms for DHX57

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DHX57 expression in normal human tissues (normalized intensities) DHX57 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AAGAGAAATA

About this image

DHX57 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database


Brain (Nervous System) fully expand to see all 13 entries
Cerebral Cortex
Septum

DHX57 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

DHX57 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.468226

Custom PCR Arrays for DHX57

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX57

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX57 gene from Selected species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dhx57^{1 , 5}	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57^{1, 5}	84.33(n)¹ 86.98(a)¹		17 (50.63 cM)⁵ 106794¹ NM_001163759.1¹ NP_001157231.1¹ 80238304⁵
chicken (Gallus gallus)	Aves	DHX57¹	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	73.18(n) 76.59(a)		426560 XM_424198.4 XP_424198.3
lizard (Anolis carolinensis)	Reptilia	DHX57⁶	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	72(a)	1 ↔ 1	1(253984454-254026256)
African clawed frog (Xenopus laevis)	Amphibia	48026484²	--	70.57(n)		48026484
zebrafish (Danio rerio)	Actinopterygii	dhx57¹	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	61.41(n) 61.76(a)		555250 XM_001921028.2 XP_001921063.2
fruit fly (Drosophila melanogaster)	Insecta	CG1582¹	CG1582	49.81(n) 44.68(a)		32021 NM_132435.1 NP_572663.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	(YLR419W)⁴	Putative helicase with limited sequence similarity more	--		12(958428-962735) 851137 NP_013523.1
rice (Oryza sativa)	Liliopsida	Os.2502²	Oryza sativa (japonica cultivar-group) putative ATP-dependent more	76.41(n)		NM_196962.1

ENSEMBL Gene Tree for DHX57 (if available)
TreeFam Gene Tree for DHX57 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for DHX57 gene

DHX29² DHX30² DHX36² TDRD9² YTHDC2² DHX9²

4 SIMAP similar genes for DHX57 using alignment to 7 protein entries: DHX57_HUMAN (see all proteins):

DHX29 DHX36 HIG-1 DKFZp762F2011

DHX57 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs192100183^1,2		--	39024501(+)	`TTTCTA/GCTCAG`	1	--	int¹		0	--	--	--	--
rs76091425^1,2	C,F	--	39024722(+)	`CCTTCG/AGTGAT`	1	--	int¹		1		WA	118
rs79224990^1,2	C,F	--	39024784(+)	`TATGAC/TGACAT`	1	--	int¹		2		WA	120
rs1063637^1,2	C	--	39025017(-)	`GACTGA/CGAGAA`	1	--	ut3¹		1		NA	2
rs1063636^1,2	C	--	39025043(-)	`TTTTTC/TTTTTC`	1	--	ut3¹		0	--	--	--	--
rs34252629^1,2	C	--	39025044(+)	`AAAAG-/AAAAAA`	1	--	ut3¹		0	--	--	--	--
rs138987065^1,2	C	--	39025352(+)	`CCCAAC/TAGGTC`	1	--	ut3¹		0	--	--	--	--
rs184277708^1,2	C	--	39025397(+)	`CAGGTA/GAGCTA`	1	--	ut3¹		0	--	--	--	--
rs199851623^1,2	C	--	39025429(+)	`CTCTCA/TAAGAC`	1	--	ut3¹		0	--	--	--	--
rs201336111^1,2		--	39025495(+)	`CGAGGA/GCACGT`	2	C	syn¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DHX57 (39024871 - 39103075 bp)

Structural Variations
Database of Genomic Variants (DGV) 8 variations for DHX57: About this table

Variant ID	Type	Subtype	PubMed ID
esv1777011	CNV	Deletion	17803354
esv2719952	CNV	Deletion	23290073
esv1005417	CNV	Deletion	20482838
esv4781	CNV	Deletion	18987735
esv268479	CNV	Insertion	20981092
esv6905	CNV	Loss	19470904
nsv9646	CNV	Loss	18304495
nsv2692	CNV	Loss	18451855

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing DHX57

DNA2.0 Custom Variant and Variant Library Synthesis for DHX57

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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3 diseases for DHX57: About MalaCards

obesity cerebritis malaria

DHX57 for disorders About GeneDecksing

Export disorders for DHX57 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DHX57 gene, integrated from 10 sources (see all 19):
(articles sorted by number of sources associating them with DHX57)

Utopia: connect your pdf to the dynamic
world of online information

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (Cell 2006)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W.... Wilson R.K. (Nature 2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (Sci Signal 2012)
Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)¹ Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)¹ Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (amp 2011)

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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 90957	HGNC: 20086	AceView: DHX57	Ensembl:ENSG00000163214	euGenes: HUgn90957
ECgene: DHX57	H-InvDB: DHX57

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DHX57	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DHX57 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DHX57 gene:
Search GeneIP for patents involving DHX57

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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DHX57 Gene

DEAH (Asp-Glu-Ala-Asp/His) Box Polypeptide 57

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DHX57 Gene

DEAH (Asp-Glu-Ala-Asp/His) Box Polypeptide 57

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