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DHX57 Gene

protein-coding   GIFtS: 53
GCID: GC02M039025

DEAH (Asp-Glu-Ala-Asp/His) Box Polypeptide 57

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEAH (Asp-Glu-Ala-Asp/His) Box Polypeptide 571 2     Putative ATP-Dependent RNA Helicase DHX572
DEAH Box Protein 572 3     EC 3.6.4.133
DDX572     EC 3.6.18
DEAH-Box RNA/DNA Helicase AAM735472     

External Ids:    HGNC: 200861   Entrez Gene: 909572   Ensembl: ENSG000001632147   UniProtKB: Q6P1583   

Export aliases for DHX57 gene to outside databases

Previous GC identifers: GC02M038982 GC02M038999 GC02M038936 GC02M038878 GC02M038763


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DHX57 Gene:
DHX57 (DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57) is a protein-coding gene. Diseases associated with DHX57 include obesity, and cerebritis. GO annotations related to this gene include ATP-dependent helicase activity and nucleic acid binding. An important paralog of this gene is DHX29.

UniProtKB/Swiss-Prot: DHX57_HUMAN, Q6P158
Function: Probable ATP-binding RNA helicase

Gene Wiki entry for DHX57 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the DHX57 gene promoter:
         E2F-3a   E2F-4   C/EBPbeta   E2F-5   E2F-2   CUTL1   Evi-1   Pax-3   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DHX57 promoter sequence
   Search Chromatin IP Primers for DHX57

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DHX57


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.1   Ensembl cytogenetic band:  2p22.1   HGNC cytogenetic band: 2p22.3

DHX57 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHX57 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M039025:  view genomic region     (about GC identifiers)

Start:
39,024,871 bp from pter      End:
39,103,075 bp from pter
Size:
78,205 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DHX57_HUMAN, Q6P158 (See protein sequence)
Recommended Name: Putative ATP-dependent RNA helicase DHX57  
Size: 1386 amino acids; 155604 Da
Sequence caution: Sequence=AAM73547.1; Type=Erroneous initiation; Sequence=AAY24256.1; Type=Erroneous gene model
prediction;
Secondary accessions: A2RRC7 Q53SI4 Q6P9G1 Q7Z6H3 Q8NG17 Q96M33
Alternative splicing: 3 isoforms:  Q6P158-1   Q6P158-2   Q6P158-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DHX57: NX_Q6P158

Explore proteomics data for DHX57 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DHX57 (Q6P158) (see all 7)
     TNIAETS  AETSITI  VDEVHER  VILMSAT 


    See DHX57 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_945314.1  
    ENSEMBL proteins: 
     ENSP00000295373   ENSP00000397841   ENSP00000405111   ENSP00000387404   ENSP00000400702  

    DHX57 Human Recombinant Protein Products:

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    OriGene Custom Protein Services for DHX57
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DHX57

    DHX57 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for DHX57
    Cloud-Clone Corp. Antibodies for DHX57
    ThermoFisher Antibodies for DHX57
    LSBio Antibodies in human, mouse, rat for DHX57

    DHX57 Assay Products:

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    Cloud-Clone Corp. CLIAs for DHX57


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DHX: DEAH-boxes

    Selected InterPro protein domains (see all 11):
     IPR000571 Znf_CCCH
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR002464 DNA/RNA_helicase_DEAH_CS
     IPR009060 UBA-like
     IPR006575 RWD-domain

    Graphical View of Domain Structure for InterPro Entry Q6P158

    ProtoNet protein and cluster: Q6P158

    4 Blocks protein domains:
    IPB000571 Zn-finger
    IPB002464 ATP-dependent helicase
    IPB006575 RWD
    IPB007502 Helicase-associated region


    UniProtKB/Swiss-Prot: DHX57_HUMAN, Q6P158
    Similarity: Belongs to the DEAD box helicase family. DEAH subfamily
    Similarity: Contains 1 C3H1-type zinc finger
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain
    Similarity: Contains 1 UBA domain


    DHX57 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DHX57_HUMAN, Q6P158
    Function: Probable ATP-binding RNA helicase
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0004386helicase activity ----
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0008026ATP-dependent helicase activity IEA--
         
    DHX57 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DHX57
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DHX57

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DHX57
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DHX57

    miRNA
    Products:
        
    miRTarBase miRNAs that target DHX57:
    hsa-let-7b-5p (MIRT001639), hsa-mir-590-3p (MIRT016202), hsa-mir-23b-3p (MIRT023464), hsa-let-7a-5p (MIRT052544), hsa-let-7e-5p (MIRT051546), hsa-mir-744-5p (MIRT037449), hsa-mir-15a-3p (MIRT038983), hsa-let-7d-5p (MIRT051721), hsa-mir-98-5p (MIRT027741), hsa-mir-125b-5p (MIRT045910), hsa-mir-877-3p (MIRT037095)

    Block miRNA regulation of human, mouse, rat DHX57 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DHX57 (see all 18):
    hsa-miR-181c hsa-let-7d hsa-let-7c hsa-miR-218 hsa-let-7g hsa-miR-320e hsa-let-7a hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidDHX57 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DHX57
    Predesigned siRNA for gene silencing in human, mouse, rat DHX57

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for DHX57

    Clone
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    OriGene clones in human, mouse for DHX57 (see all 6)
    OriGene ORF clones in mouse, rat for DHX57
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DHX57 (NM_198963)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHX57
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX57

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for DHX57
    Browse ESI BIO Cell Lines and PureStem Progenitors for DHX57 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX57


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytoskeleton1
    cytosol1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DHX57
    Interactions:

        Search GeneGlobe Interaction Network for DHX57

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DHX57 (Q6P1582, 3 ENSP000002953734) via UniProtKB, MINT, STRING, and/or I2D (see all 124)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX56Q9NY933, ENSP000002587724I2D: score=2 STRING: ENSP00000258772
    LYARQ9NX583, ENSP000003459174I2D: score=2 STRING: ENSP00000345917
    DDX21Q9NR302, ENSP000003461204MINT-8395092 STRING: ENSP00000346120
    NAT10Q9H0A02, ENSP000002578294MINT-8395092 STRING: ENSP00000257829
    GABARAPO951663I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DHX57



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DHX57 gene: 
    NM_198963.1  

    Unigene Cluster for DHX57:

    DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
    Hs.468226  [show with all ESTs]
    Unigene Representative Sequence: BC153875
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295373(uc002rre.3 uc002rrf.3) ENST00000452978 ENST00000460193(uc002rrd.4)
    ENST00000457308 ENST00000477981 ENST00000497514 ENST00000442331 ENST00000474104(uc002rrg.3)
    ENST00000492042 ENST00000479345 ENST00000417233
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DHX57 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DHX57 (see all 18):
    hsa-miR-181c hsa-let-7d hsa-let-7c hsa-miR-218 hsa-let-7g hsa-miR-320e hsa-let-7a hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidDHX57 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DHX57
    Predesigned siRNA for gene silencing in human, mouse, rat DHX57
    Clone
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    OriGene clones in human, mouse for DHX57 (see all 6)
    OriGene ORF clones in mouse, rat for DHX57
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DHX57 (NM_198963)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHX57
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX57
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DHX57
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DHX57
      QuantiTect SYBR Green Assays in human, mouse, rat DHX57
      QuantiFast Probe-based Assays in human, mouse, rat DHX57

    Additional mRNA sequence: 

    AB209249.1 AF070590.1 AF283512.1 AK057423.1 AK296739.1 AK307514.1 BC012454.1 BC033636.1 
    BC039270.1 BC053623.1 BC060778.1 BC065278.1 BC131534.1 BC153875.1 

    10 DOTS entries:

    DT.441867  DT.303178  DT.442758  DT.101975844  DT.40117842  DT.110310  DT.92418889  DT.120931050 
    DT.120931024  DT.92418888 

    Selected AceView cDNA sequences (see all 110):

    AI125363 AI203420 AA099678 CR620209 BU183594 BF970974 AA278968 AA431613 
    NM_198963 AI204143 BM352293 BQ719095 BF739883 BX102332 BC065278 AF070590 
    NM_145646 BU189567 AA343694 BC053623 BE219229 AK057423 AA236829 AI453361 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DHX57 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
    SP1:                                                                          -                                   -                                             
    SP2:                                                                          -                 -                 -                                             
    SP3:                                                                          -                 -                                                               
    SP4:                                                                                                                                                            
    SP5:              -     -                                                                                                                                       

    ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b
    SP1:                                                            
    SP2:                                                            
    SP3:                                      -                     
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for DHX57

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DHX57 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAGAAATA
    DHX57 Expression
    About this image


    DHX57 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Cerebral Cortex
             Septum   
    DHX57 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DHX57 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.468226
        Custom PCR Arrays for DHX57
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for DHX57
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DHX57
    QuantiTect SYBR Green Assays in human, mouse, rat DHX57
    QuantiFast Probe-based Assays in human, mouse, rat DHX57
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX57

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DHX57 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dhx571 , 5 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 571, 5 84.33(n)1
    86.98(a)1
      17 (50.63 cM)5
    1067941  NM_001163759.11  NP_001157231.11 
     802383045 
    chicken
    (Gallus gallus)
    Aves DHX571 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 73.18(n)
    76.59(a)
      426560  XM_424198.4  XP_424198.3 
    lizard
    (Anolis carolinensis)
    Reptilia DHX576
    DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
    72(a)
    1 ↔ 1
    1(253984454-254026256)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480264842   -- 70.57(n)    48026484 
    zebrafish
    (Danio rerio)
    Actinopterygii dhx571 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 61.41(n)
    61.76(a)
      555250  XM_001921028.2  XP_001921063.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG15821 CG1582 49.81(n)
    44.68(a)
      32021  NM_132435.1  NP_572663.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YLR419W)4 Putative helicase with limited sequence similarity more   --   12(958428-962735) 851137  NP_013523.1 
    rice
    (Oryza sativa)
    Liliopsida Os.25022 Oryza sativa (japonica cultivar-group) putative ATP-dependent more 76.41(n)    NM_196962.1 


    ENSEMBL Gene Tree for DHX57 (if available)
    TreeFam Gene Tree for DHX57 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DHX57 gene
    DHX292  DHX302  DHX362  TDRD92  YTHDC22  DHX92  
    4 SIMAP similar genes for DHX57 using alignment to 7 protein entries:     DHX57_HUMAN (see all proteins):
    DHX29    DHX36    HIG-1    DKFZp762F2011

    DHX57 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DHX57 (see all 1821)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1921001831,2
    --39024501(+) TTTCTA/GCTCAG 1 -- int10--------
    rs760914251,2
    C,F--39024722(+) CCTTCG/AGTGAT 1 -- int11Minor allele frequency- A:0.02WA 118
    rs792249901,2
    C,F--39024784(+) TATGAC/TGACAT 1 -- int12Minor allele frequency- T:0.02WA 120
    rs10636371,2
    C--39025017(-) GACTGA/CGAGAA 1 -- ut311Minor allele frequency- C:0.00NA 2
    rs10636361,2
    C--39025043(-) TTTTTC/TTTTTC 1 -- ut310--------
    rs342526291,2
    C--39025044(+) AAAAG-/AAAAAA 1 -- ut310--------
    rs1389870651,2
    C--39025352(+) CCCAAC/TAGGTC 1 -- ut310--------
    rs1842777081,2
    C--39025397(+) CAGGTA/GAGCTA 1 -- ut310--------
    rs1998516231,2
    C--39025429(+) CTCTCA/TAAGAC 1 -- ut310--------
    rs2013361111,2
    --39025495(+) CGAGGA/GCACGT 2 C syn10--------

    HapMap Linkage Disequilibrium report for DHX57 (39024871 - 39103075 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for DHX57:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1777011CNV Deletion17803354
    esv2719952CNV Deletion23290073
    esv1005417CNV Deletion20482838
    esv4781CNV Deletion18987735
    esv268479CNV Insertion20981092
    esv6905CNV Loss19470904
    nsv9646CNV Loss18304495
    nsv2692CNV Loss18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    3 diseases for DHX57:    
    About MalaCards
    obesity    cerebritis    malaria


    DHX57 for disorders           About GeneDecksing


    Export disorders for DHX57 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DHX57 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with DHX57)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    6. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    7. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 90957 HGNC: 20086 AceView: DHX57 Ensembl:ENSG00000163214 euGenes: HUgn90957
    ECgene: DHX57 H-InvDB: DHX57

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DHX57 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DHX57 gene:
    Search GeneIP for patents involving DHX57

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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