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DHX57 Gene(Protein Coding)

DExH-Box Helicase 57

GCID:
GC02M038763
GIFtS:
48
Genes Participants
UDN Logo

Aliases for DHX57 Gene

Aliases for DHX57 Gene

  • DExH-Box Helicase 57 2 3 5
  • DEAH (Asp-Glu-Ala-Asp/His) Box Polypeptide 57 2 3
  • DEAH Box Protein 57 3 4
  • Putative ATP-Dependent RNA Helicase DHX57 3
  • DEAH-Box RNA/DNA Helicase AAM73547 3
  • DEAH-Box Helicase 57 3
  • EC 3.6.4.13 4
  • EC 3.6.1 61
  • DDX57 3

External Ids for DHX57 Gene

Previous GeneCards Identifiers for DHX57 Gene

  • GC02M038982
  • GC02M038999
  • GC02M038936
  • GC02M038878
  • GC02M039025

Summaries for DHX57 Gene

GeneCards Summary for DHX57 Gene

DHX57 (DExH-Box Helicase 57) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DHX36.

UniProtKB/Swiss-Prot for DHX57 Gene

  • Probable ATP-binding RNA helicase.

Gene Wiki entry for DHX57 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX57 Gene

Genomics for DHX57 Gene

Products:

  1. Regulatory Element

Regulatory Elements for DHX57 Gene

Enhancers for DHX57 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F038540 1.6 FANTOM5 Ensembl ENCODE 13.8 +333.5 333494 3.4 PKNOX1 ARNT MLX ZFP64 ARID4B FEZF1 DMAP1 PAF1 REST KAT8 DHX57 ENSG00000235586 HNRNPLL ENSG00000232518 GALM CYP1B1 MORN2 LOC101929596 ENSG00000271443 GC02M038560
GH02F038907 1 ENCODE 20.9 -32.2 -32242 2.1 ZFP64 ARID4B ZNF48 CBX5 ZNF202 SP5 JUNB REST ZNF623 PPARG SOS1 ASS1P2 DHX57 ARHGEF33 RNU6-851P MORN2 ENSG00000225284 GC02M038898 GC02P038937
GH02F039215 1.5 FANTOM5 Ensembl ENCODE 9.7 -341.3 -341336 2.8 HDAC1 RARA GATA4 GATA2 SIRT6 CREM CEBPB ZNF518A ZNF781 CEBPA SOS1 ARHGEF33 ENSG00000202309 ENSG00000252473 DHX57 MORN2 CDKL4 GC02M039185
GH02F038946 1.2 Ensembl ENCODE 10.8 -71.5 -71525 1.1 ELF3 ARID4B DNMT3B RAD21 ZNF48 RARA RFX5 SCRT2 ZNF143 FOS DHX57 MORN2 ENSG00000225284 LOC105374471 RN7SL96P
GH02F038874 1.1 ENCODE 11.3 +0.1 89 1.8 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 DHX57 ENSG00000225284
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DHX57 on UCSC Golden Path with GeneCards custom track

Promoters for DHX57 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000012547 134 2401 HDGF CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 FOS SP3

Transcription factor binding sites by QIAGEN in the DHX57 gene promoter:

Genomic Location for DHX57 Gene

Chromosome:
2
Start:
38,797,729 bp from pter
End:
38,875,934 bp from pter
Size:
78,206 bases
Orientation:
Minus strand

Genomic View for DHX57 Gene

Genes around DHX57 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX57 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX57 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DHX57 Gene

Proteins for DHX57 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for DHX57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P158-DHX57_HUMAN
    Recommended name:
    Putative ATP-dependent RNA helicase DHX57
    Protein Accession:
    Q6P158
    Secondary Accessions:
    • A2RRC7
    • Q53SI4
    • Q6P9G1
    • Q7Z6H3
    • Q8NG17
    • Q96M33

    Protein attributes for DHX57 Gene

    Size:
    1386 amino acids
    Molecular mass:
    155604 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAM73547.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAY24256.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for DHX57 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHX57 Gene

Protein Expression for DHX57 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for DHX57 Gene

Q6P158:
  • DVVYVID
  • VDEVHER
  • AETSITI
  • VILMSAT
  • TNIAETS
  • TQPRRISA
  • GKTTQIPQ

Post-translational modifications for DHX57 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHX57 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for DHX57 Gene

Gene Families for DHX57 Gene

HGNC:

Protein Domains for DHX57 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DHX57 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P158

UniProtKB/Swiss-Prot:

DHX57_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DEAH subfamily.
  • Contains 1 C3H1-type zinc finger.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Contains 1 UBA domain.
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily.
Similarity:
  • Contains 1 C3H1-type zinc finger.
genes like me logo Genes that share domains with DHX57: view

Function for DHX57 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for DHX57 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Probable ATP-binding RNA helicase.

Enzyme Numbers (IUBMB) for DHX57 Gene

Gene Ontology (GO) - Molecular Function for DHX57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DHX57: view
genes like me logo Genes that share phenotypes with DHX57: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHX57 Gene

Localization for DHX57 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHX57 gene
Compartment Confidence
nucleus 4
mitochondrion 3
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for DHX57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005739 mitochondrion IBA --
genes like me logo Genes that share ontologies with DHX57: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DHX57 Gene

Pathways & Interactions for DHX57 Gene

SuperPathways for DHX57 Gene

PathCards logo More details on SuperPathways for DHX57
No Data Available

Gene Ontology (GO) - Biological Process for DHX57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IBA --
genes like me logo Genes that share ontologies with DHX57: view

No data available for Pathways by source and SIGNOR curated interactions for DHX57 Gene

Drugs & Compounds for DHX57 Gene

Products:

  1. Drug

(3) Drugs for DHX57 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for DHX57 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
 Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DHX57: view

Transcripts for DHX57 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for DHX57 Gene

(6) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(110) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DHX57 Gene

DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX57 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - -
SP2: - - -
SP3: - -
SP4:
SP5: - -
SP6: - -
SP7: - -

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:

Relevant External Links for DHX57 Gene

GeneLoc Exon Structure for
DHX57
ECgene alternative splicing isoforms for
DHX57

Expression for DHX57 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DHX57 Gene

mRNA expression in normal human tissues for DHX57 Gene
mRNA expression by BioGPS for DHX57 GenemRNA expression by GTEx for DHX57 Gene

Protein differential expression in normal tissues from HIPED for DHX57 Gene

This gene is overexpressed in Lung (29.5), Adrenal (12.7), and Pancreatic juice (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DHX57 Gene



Protein tissue co-expression partners for DHX57 Gene

NURSA nuclear receptor signaling pathways regulating expression of DHX57 Gene:

DHX57

SOURCE GeneReport for Unigene cluster for DHX57 Gene:

Hs.468226
genes like me logo Genes that share expression patterns with DHX57: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DHX57 Gene

Orthologs for DHX57 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX57 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia DHX57 34 35
  • 99.51 (n)
dog
(Canis familiaris)
 Mammalia DHX57 34 35
  • 91.22 (n)
cow
(Bos Taurus)
 Mammalia DHX57 34 35
  • 90.39 (n)
mouse
(Mus musculus)
 Mammalia Dhx57 34 16 35
  • 84.33 (n)
rat
(Rattus norvegicus)
 Mammalia Dhx57 34
  • 84.16 (n)
oppossum
(Monodelphis domestica)
 Mammalia DHX57 35
  • 80 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia DHX57 35
  • 78 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves DHX57 34 35
  • 73.18 (n)
lizard
(Anolis carolinensis)
 Reptilia DHX57 35
  • 72 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia dhx57 34
  • 66.27 (n)
zebrafish
(Danio rerio)
 Actinopterygii dhx57 34 35
  • 61.41 (n)
fruit fly
(Drosophila melanogaster)
 Insecta CG1582 34 35
  • 49.81 (n)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP002223 34
  • 48.14 (n)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes -- 35
  • 22 (a)
 OneToMany
rice
(Oryza sativa)
 Liliopsida Os.2502 34
Species where no ortholog for DHX57 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DHX57 Gene

ENSEMBL:
Gene Tree for DHX57 (if available)
TreeFam:
Gene Tree for DHX57 (if available)

Paralogs for DHX57 Gene

Paralogs for DHX57 Gene

(4) SIMAP similar genes for DHX57 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with DHX57: view

Variants for DHX57 Gene

Sequence variations from dbSNP and Humsavar for DHX57 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1010858 -- 38,875,529(-) GGGGG(A/G)GCGGG intron-variant, upstream-variant-2KB
rs1010859 -- 38,875,386(-) TGGAT(A/G)TCTGG intron-variant, upstream-variant-2KB
rs10153768 -- 38,827,535(+) ATATA(C/T)ACACA intron-variant
rs10153769 -- 38,827,537(+) ATACA(C/T)ACATA intron-variant
rs10168789 -- 38,835,669(+) gctac(C/G)aaaga intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DHX57 Gene

Variant ID Type Subtype PubMed ID
dgv1893n106 CNV deletion 24896259
esv1005417 CNV deletion 20482838
esv1777011 CNV deletion 17803354
esv2719952 CNV deletion 23290073
esv3304200 CNV mobile element insertion 20981092
esv3337224 CNV insertion 20981092
esv3555300 CNV deletion 23714750
esv3575234 CNV gain 25503493
esv4781 CNV loss 18987735
esv6905 CNV loss 19470904
nsv1071988 CNV deletion 25765185
nsv1110738 CNV insertion 24896259
nsv1114078 CNV deletion 24896259
nsv1153058 CNV deletion 26484159
nsv2692 CNV deletion 18451855
nsv955026 CNV deletion 24416366
nsv9646 CNV loss 18304495
nsv978996 CNV duplication 23825009

Variation tolerance for DHX57 Gene

Residual Variation Intolerance Score: 22.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.84; 67.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHX57 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DHX57

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX57 Gene

Disorders for DHX57 Gene

Relevant External Links for DHX57

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHX57

No disorders were found for DHX57 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX57 Gene

Publications for DHX57 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3 64

Products for DHX57 Gene

Sources for DHX57 Gene

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