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DHX57 Gene(Protein Coding)

DEAH-Box Helicase 57

GCID:
GC02M038763
GIFtS:
49
Genes Participants
UDN Logo

Aliases for DHX57 Gene

Aliases for DHX57 Gene

  • DEAH-Box Helicase 57 2 3
  • DEAH (Asp-Glu-Ala-Asp/His) Box Polypeptide 57 2 3 5
  • DEAH Box Protein 57 3 4
  • DEAH-Box RNA/DNA Helicase AAM73547 3
  • EC 3.6.4.13 4
  • EC 3.6.1 63
  • DDX57 3

External Ids for DHX57 Gene

Previous GeneCards Identifiers for DHX57 Gene

  • GC02M038982
  • GC02M038999
  • GC02M038936
  • GC02M038878
  • GC02M039025

Summaries for DHX57 Gene

GeneCards Summary for DHX57 Gene

DHX57 (DEAH-Box Helicase 57) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DHX29.

UniProtKB/Swiss-Prot for DHX57 Gene

  • Probable ATP-binding RNA helicase.

Gene Wiki entry for DHX57 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX57 Gene

Genomics for DHX57 Gene

Products:

  1. Regulatory Element

Regulatory Elements for DHX57 Gene

Enhancers for DHX57 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DHX57 on UCSC Golden Path with GeneCards custom track

Promoters for DHX57 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DHX57 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the DHX57 gene promoter:

Genomic Location for DHX57 Gene

Chromosome:
2
Start:
38,797,729 bp from pter
End:
38,875,934 bp from pter
Size:
78,206 bases
Orientation:
Minus strand

Genomic View for DHX57 Gene

Genes around DHX57 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX57 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX57 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DHX57 Gene

Proteins for DHX57 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for DHX57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P158-DHX57_HUMAN
    Recommended name:
    Putative ATP-dependent RNA helicase DHX57
    Protein Accession:
    Q6P158
    Secondary Accessions:
    • A2RRC7
    • Q53SI4
    • Q6P9G1
    • Q7Z6H3
    • Q8NG17
    • Q96M33

    Protein attributes for DHX57 Gene

    Size:
    1386 amino acids
    Molecular mass:
    155604 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAM73547.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAY24256.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for DHX57 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHX57 Gene

Proteomics data for DHX57 Gene at MOPED

Protein Expression for DHX57 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for DHX57 Gene

Q6P158:

Post-translational modifications for DHX57 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHX57 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for DHX57 Gene

Gene Families for DHX57 Gene

HGNC:

Protein Domains for DHX57 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DHX57 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P158

UniProtKB/Swiss-Prot:

DHX57_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DEAH subfamily.
  • Contains 1 C3H1-type zinc finger.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Contains 1 UBA domain.
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily.
Similarity:
  • Contains 1 C3H1-type zinc finger.
genes like me logo Genes that share domains with DHX57: view

Function for DHX57 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for DHX57 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Probable ATP-binding RNA helicase.

Enzyme Numbers (IUBMB) for DHX57 Gene

Gene Ontology (GO) - Molecular Function for DHX57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
GO:0008026 ATP-dependent helicase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DHX57: view

Phenotypes for DHX57 Gene

GenomeRNAi human phenotypes for DHX57:
genes like me logo Genes that share phenotypes with DHX57: view

Animal Model Products

miRNA for DHX57 Gene

miRTarBase miRNAs that target DHX57

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHX57 Gene

Localization for DHX57 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHX57 Gene COMPARTMENTS Subcellular localization image for DHX57 gene
Compartment Confidence
nucleus 4
mitochondrion 3
cytoskeleton 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DHX57 Gene

Pathways & Interactions for DHX57 Gene

SuperPathways for DHX57 Gene

PathCards logoMore details on SuperPathways for DHX57
No Data Available

Interacting Proteins for DHX57 Gene

Selected Interacting proteins: Q6P158-DHX57_HUMAN for DHX57 Gene via MINT UniProtKB I2D

Gene Ontology (GO) - Biological Process for DHX57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with DHX57: view

No data available for Pathways by source and SIGNOR curated interactions for DHX57 Gene

Drugs & Compounds for DHX57 Gene

Products:

  1. Drug

(1) Drugs for DHX57 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DHX57 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
 Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
 7664-38-2
Water
  • Dihydrogen oxide
  • Steam
 7732-18-5
genes like me logo Genes that share compounds with DHX57: view

Transcripts for DHX57 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for DHX57 Gene

(5) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(110) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DHX57 Gene

DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX57 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - -
SP2: - - -
SP3: - -
SP4:
SP5: - -
SP6: - -
SP7: - -

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:

Relevant External Links for DHX57 Gene

GeneLoc Exon Structure for
DHX57
ECgene alternative splicing isoforms for
DHX57

Expression for DHX57 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for DHX57 Gene

mRNA expression in normal human tissues for DHX57 Gene
mRNA expression by BioGPS for DHX57 GenemRNA expression by GTEx for DHX57 Gene

Protein differential expression in normal tissues from HIPED for DHX57 Gene

This gene is overexpressed in Lung (29.5), Adrenal (12.7), and Pancreatic juice (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for DHX57 Gene



SOURCE GeneReport for Unigene cluster for DHX57 Gene Hs.468226

genes like me logo Genes that share expression patterns with DHX57: view

Protein tissue co-expression partners for DHX57 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DHX57 Gene

Orthologs for DHX57 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX57 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia DHX57 35
  • 90.39 (n)
  • 92.44 (a)
DHX57 36
  • 91 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia DHX57 35
  • 91.22 (n)
  • 92.81 (a)
DHX57 36
  • 93 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Dhx57 35
  • 84.33 (n)
  • 86.98 (a)
Dhx57 16
Dhx57 36
  • 87 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia DHX57 35
  • 99.51 (n)
  • 99.71 (a)
DHX57 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Dhx57 35
  • 84.16 (n)
  • 86.83 (a)
oppossum
(Monodelphis domestica)
 Mammalia DHX57 36
  • 80 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia DHX57 36
  • 78 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves DHX57 35
  • 73.18 (n)
  • 76.59 (a)
DHX57 36
  • 74 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia DHX57 36
  • 72 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia dhx57 35
  • 66.27 (n)
  • 68.44 (a)
zebrafish
(Danio rerio)
 Actinopterygii dhx57 35
  • 61.41 (n)
  • 61.76 (a)
dhx57 36
  • 58 (a)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP002223 35
  • 48.14 (n)
  • 45.02 (a)
fruit fly
(Drosophila melanogaster)
 Insecta CG1582 35
  • 49.81 (n)
  • 44.68 (a)
CG1582 36
  • 40 (a)
 OneToOne
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes -- 36
  • 22 (a)
 OneToMany
rice
(Oryza sativa)
 Liliopsida Os.2502 35
Species with no ortholog for DHX57:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DHX57 Gene

ENSEMBL:
Gene Tree for DHX57 (if available)
TreeFam:
Gene Tree for DHX57 (if available)

Paralogs for DHX57 Gene

Paralogs for DHX57 Gene

(4) SIMAP similar genes for DHX57 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with DHX57: view

Variants for DHX57 Gene

Sequence variations from dbSNP and Humsavar for DHX57 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs35371077 - 38,861,113(-) AGTAT(A/G)GTGAC nc-transcript-variant, reference, missense
rs11893062 - 38,861,181(+) TCAAA(A/G)AATAT nc-transcript-variant, reference, missense
rs7598922 - 38,855,202(+) GTCCA(C/T)TCAGA nc-transcript-variant, reference, missense
rs756162 -- 38,820,923(-) AAAGG(A/T)TTTTT intron-variant
rs756338 -- 38,821,078(-) AGTTC(A/G)CAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHX57 Gene

Variant ID Type Subtype PubMed ID
nsv9646 CNV Loss 18304495
esv268479 CNV Insertion 20981092
nsv2692 CNV Loss 18451855
esv4781 CNV Deletion 18987735
esv2719952 CNV Deletion 23290073
esv1005417 CNV Deletion 20482838
esv1777011 CNV Deletion 17803354
esv6905 CNV Loss 19470904

Variation tolerance for DHX57 Gene

Residual Variation Intolerance Score: 22.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.84; 67.17% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DHX57 Gene

Disorders for DHX57 Gene

Relevant External Links for DHX57

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHX57

No disorders were found for DHX57 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX57 Gene

Publications for DHX57 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 67
  2. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for DHX57 Gene

Sources for DHX57 Gene

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