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Aliases for DHX40 Gene

Aliases for DHX40 Gene

  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 40 2 3
  • DDX40 3 4 6
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 40 (RNA Helicase) 2 3
  • DEAH Box Protein 40 3 4
  • Probable ATP-Dependent RNA Helicase DHX40 3
  • Protein PAD 4
  • EC 4
  • EC 3.6.1 63
  • ARG147 3
  • PAD 3

External Ids for DHX40 Gene

Previous HGNC Symbols for DHX40 Gene

  • DDX40

Previous GeneCards Identifiers for DHX40 Gene

  • GC17P057984
  • GC17P058117
  • GC17P054997
  • GC17P057642
  • GC17P053003

Summaries for DHX40 Gene

Entrez Gene Summary for DHX40 Gene

  • This gene encodes a member of the DExH/D box family of ATP-dependent RNA helicases that have an essential role in RNA metabolism. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 17.[provided by RefSeq, Oct 2009]

GeneCards Summary for DHX40 Gene

DHX40 (DEAH (Asp-Glu-Ala-His) Box Polypeptide 40) is a Protein Coding gene. Diseases associated with DHX40 include norum disease. GO annotations related to this gene include nucleic acid binding and ATP-dependent helicase activity. An important paralog of this gene is DHX38.

UniProtKB/Swiss-Prot for DHX40 Gene

  • Probable ATP-dependent RNA helicase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX40 Gene

Genomics for DHX40 Gene

Regulatory Elements for DHX40 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DHX40 Gene

59,565,525 bp from pter
59,608,352 bp from pter
42,828 bases
Plus strand

Genomic View for DHX40 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHX40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX40 Gene

Proteins for DHX40 Gene

  • Protein details for DHX40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ATP-dependent RNA helicase DHX40
    Protein Accession:
    Secondary Accessions:
    • B3KTJ5
    • C9JR60
    • Q5JPH4
    • Q8TC86
    • Q8WY53
    • Q9BXM1
    • Q9H6M9

    Protein attributes for DHX40 Gene

    779 amino acids
    Molecular mass:
    88560 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF70326.1; Type=Frameshift; Positions=758; Evidence={ECO:0000305}; Sequence=AAK32122.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15226.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DHX40 Gene


neXtProt entry for DHX40 Gene

Proteomics data for DHX40 Gene at MOPED

Selected DME Specific Peptides for DHX40 Gene

Post-translational modifications for DHX40 Gene

  • Ubiquitination at Lys387
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains for DHX40 Gene

Gene Families for DHX40 Gene

Suggested Antigen Peptide Sequences for DHX40 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DEAH subfamily.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX40: view

Function for DHX40 Gene

Molecular function for DHX40 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function:
Probable ATP-dependent RNA helicase.

Enzyme Numbers (IUBMB) for DHX40 Gene

Gene Ontology (GO) - Molecular Function for DHX40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity --
GO:0005524 ATP binding IEA --
GO:0008026 ATP-dependent helicase activity --
genes like me logo Genes that share ontologies with DHX40: view

Phenotypes for DHX40 Gene

genes like me logo Genes that share phenotypes with DHX40: view

Animal Model Products

miRNA for DHX40 Gene

miRTarBase miRNAs that target DHX40

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DHX40

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for DHX40 Gene

Localization for DHX40 Gene

Subcellular locations from

Jensen Localization Image for DHX40 Gene COMPARTMENTS Subcellular localization image for DHX40 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for DHX40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DHX40: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DHX40 Gene

Pathways for DHX40 Gene

SuperPathways for DHX40 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHX40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006396 RNA processing IBA --
GO:0006810 transport --
genes like me logo Genes that share ontologies with DHX40: view

No data available for Pathways by source for DHX40 Gene

Drugs for DHX40 Gene

(4) HMDB Compounds for DHX40 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(Tetrahydrogen triphosphate) Adenosine
  • Adenosindiphosphorsaeure
Phosphoric acid
  • Acide phosphorique (FRENCH)
  • Dihydrogen oxide
genes like me logo Genes that share compounds with DHX40: view

Transcripts for DHX40 Gene

Unigene Clusters for DHX40 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 40:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DHX40

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX40 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
SP1: -
SP2: - -
SP3: -
SP5: -

Relevant External Links for DHX40 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHX40 Gene

mRNA expression in normal human tissues for DHX40 Gene

Protein differential expression in normal tissues for DHX40 Gene

This gene is overexpressed in Breast (10.3), Fetal ovary (9.0), Peripheral blood mononuclear cells (7.0), Testis (6.7), and Adipocyte (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHX40 Gene

SOURCE GeneReport for Unigene cluster for DHX40 Gene Hs.29403

mRNA Expression by UniProt/SwissProt for DHX40 Gene

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with DHX40: view

Expression partners for DHX40 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DHX40 Gene

Orthologs for DHX40 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DHX40 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DHX40 35
  • 94.05 (n)
  • 98.59 (a)
DHX40 36
  • 99 (a)
(Canis familiaris)
Mammalia DHX40 35
  • 95.55 (n)
  • 98.72 (a)
DHX40 36
  • 98 (a)
(Mus musculus)
Mammalia Dhx40 35
  • 91.57 (n)
  • 97.56 (a)
Dhx40 16
Dhx40 36
  • 98 (a)
(Pan troglodytes)
Mammalia DHX40 35
  • 98.31 (n)
  • 97.87 (a)
DHX40 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Dhx40 35
  • 91.66 (n)
  • 97.56 (a)
(Monodelphis domestica)
Mammalia DHX40 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia DHX40 36
  • 76 (a)
(Gallus gallus)
Aves DHX40 35
  • 70.63 (n)
  • 71.68 (a)
DHX40 36
  • 70 (a)
(Anolis carolinensis)
Reptilia DHX40 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx40 35
  • 68.23 (n)
  • 67.36 (a)
Str.14904 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.21302 35
(Danio rerio)
Actinopterygii dhx40 35
  • 65.02 (n)
  • 66.53 (a)
dhx40 36
  • 66 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP16 36
  • 24 (a)
Species with no ortholog for DHX40:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DHX40 Gene

Gene Tree for DHX40 (if available)
Gene Tree for DHX40 (if available)

Paralogs for DHX40 Gene

Paralogs for DHX40 Gene Pseudogenes for DHX40 Gene

genes like me logo Genes that share paralogs with DHX40: view

Variants for DHX40 Gene

Sequence variations from dbSNP and Humsavar for DHX40 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs150579386 -- 59,570,081(+) ATATT(A/T)ATATA intron-variant
rs150562488 -- 59,606,562(+) TAACA(C/T)GGTGA intron-variant
rs150525827 -- 59,567,020(+) AATCT(C/T)AAATA intron-variant
rs150466039 -- 59,572,517(+) GGGAC(A/T)ACAGG intron-variant
rs182440813 -- 59,601,207(+) CAGCA(G/T)GGTGA intron-variant

Relevant External Links for DHX40 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DHX40 Gene

Disorders for DHX40 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for DHX40 Gene in MalaCards »

(1) Disease for DHX40 Gene

(1) University of Copenhagen DISEASES for DHX40 Gene

genes like me logo Genes that share disorders with DHX40: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for DHX40 Gene

Publications for DHX40 Gene

  1. Identification of a novel human DDX40 gene, a new member of the DEAH- box protein family. (PMID: 12522690) Xu J. … Mao Y. (J. Hum. Genet. 2002) 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3
  5. The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. (PMID: 20811636) Giannone R.J. … Liu Y. (PLoS ONE 2010) 3

Products for DHX40 Gene

Sources for DHX40 Gene

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