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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DHX40 Gene

protein-coding GIFtS: 51
GCID: GC17P057642

DEAH (Asp-Glu-Ala-His) box polypeptide 40

(Previous name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 40 (RNA helicase)...)
(Previous symbol: DDX40)

Explore 1 disease affiliated with
DHX40 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
DEAH (Asp-Glu-Ala-His) Box Polypeptide 40¹ ²		FLJ22060¹
DDX40¹ ² ³ ⁵		Probable ATP-Dependent RNA Helicase DHX40²
PAD¹ ²		EC 3.6.4.13³
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 40 (RNA Helicase)¹ ²		Protein PAD³
DEAH Box Protein 40² ³		EC 3.6.1⁸
ARG147¹

External Ids:	HGNC: 18018¹	Entrez Gene: 79665²	Ensembl: ENSG00000108406⁷	OMIM: 607570⁵	UniProtKB: Q8IX18³

Export aliases for DHX40 gene to outside databases

Previous GC identifers: GC17P057984 GC17P058117 GC17P054997 GC17P053003

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DHX40:

This gene encodes a member of the DExH/D box family of ATP-dependent RNA helicases that have an essential role in RNA

metabolism. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on

chromosome 17.(provided by RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: DHX40_HUMAN, Q8IX18

Function: Probable ATP-dependent RNA helicase (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DHX40 gene promoter:
MEF-2A POU2F1 FOXF2 NRSF form 1 POU2F1a aMEF-2 NRSF form 2 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DHX40 promoter sequence

Search SABiosciences Chromatin IP Primers for DHX40

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHX40

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.1 Ensembl cytogenetic band: 17q23.1 HGNC cytogenetic band: 17q22

DHX40 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHX40 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P057642: view genomic region (about GC identifiers)

Start:	57,642,886 bp from pter	End:	57,685,713 bp from pter
Size:	42,828 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DHX40_HUMAN, Q8IX18 (See protein sequence)

Recommended Name: Probable ATP-dependent RNA helicase DHX40

Size: 779 amino acids; 88560 Da

Sequence caution: Sequence=AAF70326.1; Type=Frameshift; Positions=758; Sequence=AAK32122.1; Type=Erroneous initiation;

Sequence=BAB15226.1; Type=Erroneous initiation;

Secondary accessions: B3KTJ5 Q5JPH4 Q8TC86 Q8WY53 Q9BXM1 Q9H6M9

Alternative splicing: 3 isoforms: Q8IX18-1 Q8IX18-2 Q8IX18-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DHX40: NX_Q8IX18

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IX18

4/8 DME Specific Peptides for DHX40 (Q8IX18) (see all 8)

TDILFGL

IKYMTDG

LDEAHERT

DEAHERTL

DHX40 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001159773.1 NP_078888.4

ENSEMBL proteins:

ENSP00000251241 ENSP00000462702 ENSP00000462246 ENSP00000388749 ENSP00000463025

ENSP00000462686 ENSP00000437958 ENSP00000396039

Human Recombinant Protein Products for DHX40:

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	GenScript Custom Purified and Recombinant Proteins Services for DHX40
	Novus Biologicals DHX40 Protein Novus Biologicals DHX40 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DHX40

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	Search ThermoFisher Antibodies for DHX40

Assay Products for DHX40:

	Browse Kits and Assays available from EMD Millipore
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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DHX40
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DHX40

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DHX40 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR007502 Helicase-assoc_dom

IPR011545 DNA/RNA_helicase_DEAD/DEAH_N

IPR011709 DUF1605

IPR002464 DNA/RNA_helicase_DEAH_CS

IPR014001 Helicase_ATP-bd

Graphical View of Domain Structure for InterPro Entry Q8IX18

ProtoNet protein and cluster: Q8IX18

2 Blocks protein families:

IPB002464 ATP-dependent helicase

IPB007502 Helicase-associated region

UniProtKB/Swiss-Prot: DHX40_HUMAN, Q8IX18

Similarity: Belongs to the DEAD box helicase family. DEAH subfamily

Similarity: Contains 1 helicase ATP-binding domain

Similarity: Contains 1 helicase C-terminal domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: DHX40_HUMAN, Q8IX18

Function: Probable ATP-dependent RNA helicase (By similarity)

Catalytic activity: ATP + H(2)O = ADP + phosphate

Enzyme Numbers (IUBMB): EC 3.6.1² EC 3.6.4.13¹

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0008026	ATP-dependent helicase activity	IEA	--

DHX40 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for DHX40:

Decreased viability with pacli

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DHX40

miRNA Products:		miRTarBase miRNAs that target DHX40: hsa-mir-155 (MIRT001554)

		OriGene 3'-UTR Clone: DHX40 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DHX40
		8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate DHX40 (see all 46):
		hsa-miR-300 hsa-miR-624 hsa-miR-30d hsa-miR-3142 hsa-miR-30a hsa-miR-9 hsa-miR-186 hsa-miR-155

		SwitchGear 3'UTR luciferase reporter plasmid: DHX40 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DHX40 (see all 7) OriGene siRNA: DHX40
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DHX40
		Sirion Biotech Custom design and validation of potent shRNA sequences against DHX40

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for DHX40
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DHX40 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DHX40 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): DHX40 (NM_024612)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX40

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DHX40

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/6 Interacting proteins for DHX40 (Q8IX18³ ENSP00000251241⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
G3BP1	Q13283³, ENSP00000348578⁴	I2D: score=2 STRING: ENSP00000348578
TERF2	Q15554³, ENSP00000254942⁴	I2D: score=1 STRING: ENSP00000254942
C12orf44	Q9BSB4³	I2D: score=1
UBC	ENSP00000344818⁴	STRING: ENSP00000344818
CDC40	ENSP00000304370⁴	STRING: ENSP00000304370

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DHX40
Search CenterWatch for drugs/clinical trials and news about DHX40

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DHX40 gene (2 alternative transcripts):

NM_001166301.1 NM_024612.4

Unigene Cluster for DHX40:

DEAH (Asp-Glu-Ala-His) box polypeptide 40

Hs.29403 [show with all ESTs]

Unigene Representative Sequence: AF260270

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000251241(uc002ixn.2 uc010woe.2 uc002ixo.1 uc010wof.2)

ENST00000580218 ENST00000577596 ENST00000425628 ENST00000584385 ENST00000580030

ENST00000538926 ENST00000583439 ENST00000578204 ENST00000577549 ENST00000451169

miRNA Products:		OriGene 3'-UTR Clone: DHX40 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DHX40
		8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate DHX40 (see all 46):
		hsa-miR-300 hsa-miR-624 hsa-miR-30d hsa-miR-3142 hsa-miR-30a hsa-miR-9 hsa-miR-186 hsa-miR-155

		SwitchGear 3'UTR luciferase reporter plasmid: DHX40 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DHX40 (see all 7) OriGene siRNA: DHX40
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DHX40
		Sirion Biotech Custom design and validation of potent shRNA sequences against DHX40

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DHX40 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DHX40 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): DHX40 (NM_024612)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHX40
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX40

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DHX40 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DHX40
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHX40

Additional cDNA sequence:

AF260270.1 AF319521.1 AF461690.1 AK025713.1 AK091334.1 AK095681.1 AK123683.1 AK225268.1

AK225344.1 AK226048.1 AK299151.1 AL832510.1 BC024187.2

21 DOTS entries:

DT.443082 DT.100818897 DT.120930692 DT.101978024 DT.100818898 DT.95075806 DT.95075792 DT.120930715

DT.120930739 DT.120930774 DT.40130219 DT.120930412 DT.120930454 DT.91762317 DT.91762319 DT.95234686

DT.95307146 DT.97779333 DT.97823168 DT.100027294 DT.91936060

24/212 AceView cDNA sequences (see all 212):

AI625000 AI811853 AI240433 AI269392 AI034444 BQ008521 AW086446 AI332420

AI040175 AI675355 BG741055 BF108731 AF461690 AI373898 BE884360 AI651418

AW511602 BM982037 BF112167 AW043626 AI270739 AI016103 BQ024043 AL832510

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DHX40 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	·	4c	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b
SP1:																															-
SP2:							-				-
SP3:							-
SP4:
SP5:																															-

ECgene alternative splicing isoforms for DHX40

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DHX40 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACCTAGCAT

About this image

DHX40 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See DHX40 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DHX40

SOURCE GeneReport for Unigene cluster: Hs.29403

UniProtKB/Swiss-Prot: DHX40_HUMAN, Q8IX18

Tissue specificity: Ubiquitously expressed

SABiosciences Custom PCR Arrays for DHX40

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DHX40 Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX40

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for DHX40 gene from 7/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DHX40¹	DEAH (Asp-Glu-Ala-His) box polypeptide 40	70.86(n) 72.1(a)		772090 XM_001235277.1 XP_001235278.1
lizard (Anolis carolinensis)	Reptilia	DHX40⁶	--	68(a)	1 ↔ 1	GL343470.1(397422-415702)
African clawed frog (Xenopus laevis)	Amphibia	Xl.21302²	Xenopus laevis transcribed sequence with weak similarity more	69.53(n)		BU911993.1
zebrafish (Danio rerio)	Actinopterygii	dhx40¹	DEAH (Asp-Glu-Ala-His) box polypeptide 40	65.02(n) 66.53(a)		570225 XM_693677.4 XP_698769.4
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G27900⁶	helicase associated domain-containing protein	37(a)	1 ↔ 1	1(9715453-9720568)
rice (Oryza sativa)	Liliopsida	-- --	ATP-dependent RNA helicase, putative, expressed pre-mRNA-splicing factor ATP-dependent RNA helicas...	36(a) 29(a)	1 ↔ 1 possible ortholog	11(11903086-11919239) 3(9698113-9699327)
E. coli (Escherichia coli)	Gamma proteobacteria	hrpB⁶ hrpA⁶	predicted ATP-dependent helicase	17(a) 16(a)	possible ortholog possible ortholog	Chromosome(162105-164534) Chromosome(1481085-1484987)

ENSEMBL Gene Tree for DHX40 (if available)
TreeFam Gene Tree for DHX40 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DHX40 gene

YTHDC2² DHX57² DHX35² DHX9² DHX29² DHX36² DHX30² TDRD9²

DHX33² DHX16² DHX38² DHX8²

10 SIMAP similar genes for DHX40 using alignment to 9 protein entries: DHX40_HUMAN (see all proteins):

DHX8 DHX38 DHX35 DHX15 DHX16 DHX34

DQX1 DKFZp762F2011 DHX36 DHX33

DHX40 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for DHX40
PGOHUM00000262959

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2697396^1,2		--	53035820(-)	`ATAGAC/TATGAC`	1	--	int¹		0	--	--	--	--
rs2697395^1,2		--	53035939(-)	`TAAAGC/TTGTTT`	2	Q	syn¹		0	--	--	--	--
rs2960211^1,2		--	53040325(+)	`ttataC/Gagatg`	1	--	int¹		0	--	--	--	--
rs2907259^1,2	C,H	--	53040779(+)	`agtttA/Gagacc`	1	--	int¹		0	--	--	--	--
rs4352110^1,2	C	--	53041002(-)	`TGTTTC/ATTTCT`	1	--	int¹		2		NA	4
rs4968385^1,2	C,F	--	53041320(+)	`TATACC/TTTCTA`	1	--	int¹		2		NA	4
rs2960212^1,2	C,F	--	53041402(+)	`ATAAAT/CGGATT`	1	--	int¹		3		NA	138
rs78621130^1,2	C	--	53042631(+)	`ATGTT-/AAGGTT`	1	--	int¹		0	--	--	--	--
rs75150271^1,2	C	--	53042632(-)	`AAACC-/TTAACA`	1	--	int¹		0	--	--	--	--
rs2531934^1,2	C,F	--	53042676(+)	`TTTTTG/ATTGTT`	1	--	int¹		3		NA WA	6

HapMap Linkage Disequilibrium report for DHX40 (57642886 - 57685713 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DHX40: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DHX40

DNA2.0 Custom Variant and Variant Library Synthesis for DHX40

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DHX40 for disorders           About GeneDecksing

OMIM gene information: 607570    OMIM disorders: --

1 disease for DHX40:    About MalaCards

norum disease

1 disease from the University of Copenhagen DISEASES database for DHX40:

Norum disease

Export disorders for DHX40 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DHX40 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with DHX40)

Utopia: connect your pdf to the dynamic
world of online information

Identification of a novel human DDX40 gene, a new member of the DEAH- box protein family. (PubMed id 12522690)^{1, 2, 9} Xu J.... Mao Y. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)¹ Lee K.A....Doedens J.R. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
The protein network surrounding the human telomere re peat binding factors TRF1, TRF2, and POT1. (PubMed id 20811636)¹ Giannone R.J....Liu Y. (2010)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 79665	HGNC: 18018	AceView: DHX40	Ensembl:ENSG00000108406	euGenes: HUgn79665
ECgene: DHX40	H-InvDB: DHX40

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DHX40	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DHX40 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DHX40 gene:
Search GeneIP for patents involving DHX40

GeneCards and IP:
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DHX40 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 40

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DHX40 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 40

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