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Aliases for DHX40 Gene

Aliases for DHX40 Gene

  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 40 2 3
  • DDX40 3 4 6
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 40 (RNA Helicase) 2 3
  • DEAH Box Protein 40 3 4
  • Probable ATP-Dependent RNA Helicase DHX40 3
  • Protein PAD 4
  • EC 3.6.4.13 4
  • EC 3.6.1 63
  • ARG147 3
  • PAD 3

External Ids for DHX40 Gene

Previous HGNC Symbols for DHX40 Gene

  • DDX40

Previous GeneCards Identifiers for DHX40 Gene

  • GC17P057984
  • GC17P058117
  • GC17P054997
  • GC17P057642
  • GC17P053003

Summaries for DHX40 Gene

Entrez Gene Summary for DHX40 Gene

  • This gene encodes a member of the DExH/D box family of ATP-dependent RNA helicases that have an essential role in RNA metabolism. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 17.[provided by RefSeq, Oct 2009]

GeneCards Summary for DHX40 Gene

DHX40 (DEAH (Asp-Glu-Ala-His) Box Polypeptide 40) is a Protein Coding gene. Diseases associated with DHX40 include norum disease. GO annotations related to this gene include nucleic acid binding and ATP-dependent helicase activity. An important paralog of this gene is DHX38.

UniProtKB/Swiss-Prot for DHX40 Gene

  • Probable ATP-dependent RNA helicase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX40 Gene

Genomics for DHX40 Gene

Regulatory Elements for DHX40 Gene

Genomic Location for DHX40 Gene

Start:
59,565,525 bp from pter
End:
59,608,352 bp from pter
Size:
42,828 bases
Orientation:
Plus strand

Genomic View for DHX40 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHX40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX40 Gene

Proteins for DHX40 Gene

  • Protein details for DHX40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IX18-DHX40_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DHX40
    Protein Accession:
    Q8IX18
    Secondary Accessions:
    • B3KTJ5
    • C9JR60
    • Q5JPH4
    • Q8TC86
    • Q8WY53
    • Q9BXM1
    • Q9H6M9

    Protein attributes for DHX40 Gene

    Size:
    779 amino acids
    Molecular mass:
    88560 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF70326.1; Type=Frameshift; Positions=758; Evidence={ECO:0000305}; Sequence=AAK32122.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15226.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DHX40 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHX40 Gene

Proteomics data for DHX40 Gene at MOPED

Selected DME Specific Peptides for DHX40 Gene

Post-translational modifications for DHX40 Gene

  • Ubiquitination at Lys387
  • Modification sites at PhosphoSitePlus

Domains for DHX40 Gene

Gene Families for DHX40 Gene

HGNC:
  • DHX :DEAH-boxes

Suggested Antigen Peptide Sequences for DHX40 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IX18

UniProtKB/Swiss-Prot:

DHX40_HUMAN :
  • Q8IX18
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX40: view

Function for DHX40 Gene

Molecular function for DHX40 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: Probable ATP-dependent RNA helicase.

Enzyme Numbers (IUBMB) for DHX40 Gene

Gene Ontology (GO) - Molecular Function for DHX40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity --
GO:0005524 ATP binding IEA --
GO:0008026 ATP-dependent helicase activity --
genes like me logo Genes that share ontologies with DHX40: view

Phenotypes for DHX40 Gene

genes like me logo Genes that share phenotypes with DHX40: view

miRNA for DHX40 Gene

miRTarBase miRNAs that target DHX40

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DHX40 Gene

Localization for DHX40 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHX40 Gene COMPARTMENTS Subcellular localization image for DHX40 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for DHX40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DHX40: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DHX40 Gene

Pathways for DHX40 Gene

SuperPathways for DHX40 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHX40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006396 RNA processing IBA --
GO:0006810 transport --
genes like me logo Genes that share ontologies with DHX40: view

No data available for Pathways by source for DHX40 Gene

Transcripts for DHX40 Gene

Unigene Clusters for DHX40 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 40:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHX40 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
SP1: -
SP2: - -
SP3: -
SP4:
SP5: -
SP6:

Relevant External Links for DHX40 Gene

GeneLoc Exon Structure for
DHX40
ECgene alternative splicing isoforms for
DHX40

Expression for DHX40 Gene

mRNA expression in normal human tissues for DHX40 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHX40 Gene

SOURCE GeneReport for Unigene cluster for DHX40 Gene Hs.29403

mRNA Expression by UniProt/SwissProt for DHX40 Gene

Q8IX18-DHX40_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with DHX40: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DHX40 Gene

Orthologs for DHX40 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DHX40 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHX40 35
  • 98.31 (n)
  • 97.87 (a)
DHX40 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DHX40 35
  • 94.05 (n)
  • 98.59 (a)
DHX40 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DHX40 35
  • 95.55 (n)
  • 98.72 (a)
DHX40 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dhx40 35
  • 91.57 (n)
  • 97.56 (a)
Dhx40 16
Dhx40 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DHX40 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DHX40 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dhx40 35
  • 91.66 (n)
  • 97.56 (a)
chicken
(Gallus gallus)
Aves DHX40 35
  • 70.63 (n)
  • 71.68 (a)
DHX40 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHX40 36
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21302 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx40 35
  • 68.23 (n)
  • 67.36 (a)
Str.14904 35
zebrafish
(Danio rerio)
Actinopterygii dhx40 35
  • 65.02 (n)
  • 66.53 (a)
dhx40 36
  • 66 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP16 36
  • 24 (a)
OneToMany
Species with no ortholog for DHX40:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DHX40 Gene

ENSEMBL:
Gene Tree for DHX40 (if available)
TreeFam:
Gene Tree for DHX40 (if available)

Paralogs for DHX40 Gene

Paralogs for DHX40 Gene

Pseudogenes.org Pseudogenes for DHX40 Gene

genes like me logo Genes that share paralogs with DHX40: view

Variants for DHX40 Gene

Sequence variations from dbSNP and Humsavar for DHX40 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1140061 -- 59,608,346(+) Caaaa(A/G/T)acaaa utr-variant-3-prime
rs2333551 -- 59,569,956(+) ggaga(A/G)ttgct intron-variant
rs2333552 -- 59,570,157(+) TAATA(C/T)ATATA intron-variant
rs2523371 -- 59,573,785(+) AGTCT(C/G)CTAAT reference, missense
rs2523372 -- 59,574,467(+) CATAT(A/G)TTTAT intron-variant

Relevant External Links for DHX40 Gene

HapMap Linkage Disequilibrium report
DHX40

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DHX40 Gene

Disorders for DHX40 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for DHX40 Gene including...

Search for DHX40 Gene in MalaCards »

(1) University of Copenhagen DISEASES for DHX40 Gene

genes like me logo Genes that share disorders with DHX40: view

No data available for UniProtKB/Swiss-Prot for DHX40 Gene

Publications for DHX40 Gene

  1. Identification of a novel human DDX40 gene, a new member of the DEAH- box protein family. (PMID: 12522690) Xu J. … Mao Y. (J. Hum. Genet. 2002) 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3
  5. The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. (PMID: 20811636) Giannone R.J. … Liu Y. (PLoS ONE 2010) 3

Products for DHX40 Gene

Sources for DHX40 Gene

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