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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DHX38 Gene

protein-coding GIFtS: 62
GCID: GC16P072127

DEAH (Asp-Glu-Ala-His) box polypeptide 38

(Previous name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 38 )
(Previous symbol: DDX38)

Explore 1 disease affiliated with
DHX38 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
DEAH (Asp-Glu-Ala-His) Box Polypeptide 38¹ ²		DEAH Box Protein 38² ³
DDX38¹ ² ³ ⁵		HPrp16¹
PRP16¹ ² ³ ⁵		Pre-MRNA Splicing Factor ATP-Dependent RNA Helicase PRP16²
PRPF16¹ ²		Pre-MRNA-Splicing Factor ATP-Dependent RNA Helicase PRP16²
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 38¹ ²		PRP16 Homolog Of S.Cerevisiae²
KIAA0224¹ ³		EC 3.6.4.13³
ATP-Dependent RNA Helicase DHX38² ³		EC 3.6.1⁸

External Ids:	HGNC: 17211¹	Entrez Gene: 9785²	Ensembl: ENSG00000140829⁷	OMIM: 605584⁵	UniProtKB: Q92620³

ORGUL members:
	NONCODE:n339281

Export aliases for DHX38 gene to outside databases

Previous GC identifers: GC16P071863 GC16P071904 GC16P071903 GC16P070685 GC16P057894

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DHX38:

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are

implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation

initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution

patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular

growth and division. The protein encoded by this gene is a member of the DEAD/H box family of splicing factors. This

protein resembles yeast Prp16 more closely than other DEAD/H family members. It is an ATPase and essential for the

catalytic step II in pre-mRNA splicing process. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PRP16_HUMAN, Q92620

Function: Probable ATP-binding RNA helicase involved in pre-mRNA splicing

Gene Wiki entry for DHX38

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DHX38 gene promoter:
AhR C/EBPbeta NF-1 NF-1/L p53 CUTL1 GATA-1 Arnt MZF-1 STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DHX38 promoter sequence

Search SABiosciences Chromatin IP Primers for DHX38

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHX38

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22 Ensembl cytogenetic band: 16q22.2 HGNC cytogenetic band: 16q22

DHX38 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHX38 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P072127: view genomic region (about GC identifiers)

Start:	72,127,461 bp from pter	End:	72,146,811 bp from pter
Size:	19,351 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PRP16_HUMAN, Q92620 (See protein sequence)

Recommended Name: Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

Size: 1227 amino acids; 140503 Da

Subunit: Identified in the spliceosome C complex

Subcellular location: Nucleus (By similarity)

Sequence caution: Sequence=BAA13213.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: D3DWS7 O75212 Q96HN7

Explore the universe of human proteins at neXtProt for DHX38: NX_Q92620

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92620

4/11 DME Specific Peptides for DHX38 (Q92620) (see all 11)

TNIAETS

IKYMTDG

TVPEIQR

IRFEDCT

DHX38 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_054722.2

ENSEMBL proteins:

ENSP00000268482 ENSP00000455939 ENSP00000462149 ENSP00000457887 ENSP00000462965

ENSP00000462397 ENSP00000454521 ENSP00000437898

Reactome Protein details: Q92620
Human Recombinant Protein Products:

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	Novus Biologicals DHX38 Protein
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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DHX38

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	9524131
GO:0005654	nucleoplasm	TAS	--
GO:0071013	catalytic step 2 spliceosome	IDA	11991638

DHX38 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for DHX38

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DHX38 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR007502 Helicase-assoc_dom

IPR011545 DNA/RNA_helicase_DEAD/DEAH_N

IPR011709 DUF1605

IPR002464 DNA/RNA_helicase_DEAH_CS

IPR014001 Helicase_ATP-bd

Graphical View of Domain Structure for InterPro Entry Q92620

ProtoNet protein and cluster: Q92620

2 Blocks protein families:

IPB002464 ATP-dependent helicase

IPB007502 Helicase-associated region

UniProtKB/Swiss-Prot: PRP16_HUMAN, Q92620

Similarity: Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily

Similarity: Contains 1 helicase ATP-binding domain

Similarity: Contains 1 helicase C-terminal domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PRP16_HUMAN, Q92620

Function: Probable ATP-binding RNA helicase involved in pre-mRNA splicing

Catalytic activity: ATP + H(2)O = ADP + phosphate

Enzyme Numbers (IUBMB): EC 3.6.1² EC 3.6.4.13¹

miRNA Products:		OriGene 3'-UTR Clone: DHX38 Browse MicroRNA Expression Plasmids
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		5 QIAGEN miScript miRNA Assays for microRNAs that regulate DHX38:
		hsa-miR-520d-5p hsa-miR-466 hsa-miR-513a-3p hsa-miR-524-5p hsa-miR-3941
		SwitchGear 3'UTR luciferase reporter plasmid: DHX38 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX38

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0004386	helicase activity	--	--
GO:0005524	ATP binding	IEA	--
GO:0008026	ATP-dependent helicase activity	IEA	--

DHX38 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for DHX38:

Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

mRNA Splicing - Major Pathway

mRNA Splicing	1.00	mRNA Processing	0.82
mRNA Splicing - Major Pathway	1.00	mRNA processing	0.48
Processing of Capped Intron-Containing Pre-mRNA	0.96	Spliceosome	0.31

RNA Polymerase II Transcription Termination

RNA Polymerase II Transcription Termination	1.00	Post-Elongation Processing of Intron-Containing pre-mRNA	0.79
Post-Elongation Processing of the Transcript	1.00	mRNA 3'-end processing	0.79
Cleavage of Growing Transcript in the Termination Region	1.00

Transcription

Transcription

1.00

RNA Polymerase II Transcription

0.69

Transport of Mature Transcript to Cytoplasm

Transport of Mature Transcript to Cytoplasm

1.00

Transport of Mature mRNA derived from an Intron-Containing Transcript

0.85

Generic Transcription Pathway

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for DHX38

mRNA processing

5/14 Reactome Pathways for DHX38 (see all 14)

	Transport of Mature mRNA derived from an Intron-Containing Transcript
	mRNA Splicing - Major Pathway
	Transport of Mature Transcript to Cytoplasm
	mRNA Splicing
	RNA Polymerase II Transcription

1 Kegg Pathway (Kegg details for DHX38):

Spliceosome

DHX38 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DHX38

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/169 Interacting proteins for DHX38 (Q92620^{2, 3} ENSP00000268482⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 169)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DHX16	O60231²^,³	MINT-8331635 MINT-8337640 I2D: score=1
RBM10	P98175², ENSP00000366829⁴	MINT-8334945 MINT-8332207 STRING: ENSP00000366829
GPKOW	Q92917², ENSP00000156109⁴	MINT-8331602 MINT-8337805 STRING: ENSP00000156109
SNRNP200	O75643³, ENSP00000317123⁴	I2D: score=2 STRING: ENSP00000317123
TXNL4A	P83876³, ENSP00000269601⁴	I2D: score=2 STRING: ENSP00000269601

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000398	mRNA splicing, via spliceosome	TAS	--
GO:0006366	transcription from RNA polymerase II promoter	TAS	--
GO:0006369	termination of RNA polymerase II transcription	TAS	--
GO:0006406	mRNA export from nucleus	TAS	--
GO:0008380	RNA splicing	TAS	--

DHX38 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DHX38
Search CenterWatch for drugs/clinical trials and news about DHX38 / PRP16

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DHX38 gene:

NM_014003.3

Unigene Cluster for DHX38:

DEAH (Asp-Glu-Ala-His) box polypeptide 38

Hs.151218 [show with all ESTs]

Unigene Representative Sequence: NM_014003

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000268482(uc010cgn.1 uc002fcb.3 uc010vmp.2) ENST00000566794

ENST00000579387 ENST00000566489 ENST00000564307 ENST00000563650 ENST00000566329

ENST00000569935 ENST00000562774 ENST00000563819 ENST00000564622 ENST00000567552

ENST00000567142 ENST00000569952 ENST00000536867

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DHX38
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate DHX38:
		hsa-miR-520d-5p hsa-miR-466 hsa-miR-513a-3p hsa-miR-524-5p hsa-miR-3941
		SwitchGear 3'UTR luciferase reporter plasmid: DHX38 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHX38

Additional cDNA sequence:

AF038391.1 AK291634.1 AK293776.1 AK297269.1 AK297791.1 AK301074.1 AK309391.1 AK311169.1

BC004235.2 BC008340.1 D86977.1

24/27 DOTS entries (see all 27):

DT.100786705 DT.443498 DT.100786706 DT.91953949 DT.120676149 DT.91841288 DT.120676294 DT.92459430

DT.100786697 DT.120676181 DT.406538 DT.92459420 DT.100655413 DT.100786702 DT.120676163 DT.120676180

DT.95129394 DT.97771970 DT.100645390 DT.120676084 DT.120676182 DT.75138770 DT.95129391 DT.100652587

24/269 AceView cDNA sequences (see all 269):

BM695138 BG005257 AI803031 BP381531 AI240090 AA782175 BU617072 CD721884

BM709764 CA407045 BC004235 CR598207 CA436837 BI771867 BQ948475 AI683038

BX459113 BM828434 AI969174 BU153724 NM_014003 AI439353 BQ932850 CA426783

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for DHX38 (see all 14) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	·	2d	^	3	^	4	^	5a	·	5b	·	5c	·	5d	·	5e	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	^
SP1:													-												-		-																								-
SP2:
SP3:													-												-		-		-
SP4:
SP5:																																																			-

ExUns:	16a	·	16b	^	17a	·	17b	^	18	^	19	^	20a	·	20b	·	20c	^	21a	·	21b	^	22	^	23	^	24a	·	24b	·	24c	^	25	^	26a	·	26b	^	27a	·	27b	^	28a	·	28b	^	29a	·	29b	·	29c
SP1:			-		-																														-
SP2:																																			-								-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for DHX38

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DHX38 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCGGGAGCGG

About this image

DHX38 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Reproductive System

Early Gonad

Primordial Germ Cells

Germ Cells

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See DHX38 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DHX38

SOURCE GeneReport for Unigene cluster: Hs.151218

SABiosciences Custom PCR Arrays for DHX38

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DHX38 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHX38

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX38

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for DHX38 gene from 10/36 species (see all 36) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DHX38¹	DEAH (Asp-Glu-Ala-His) box polypeptide 38	80.02(n) 90.48(a)		415875 NM_001030582.1 NP_001025753.1
lizard (Anolis carolinensis)	Reptilia	DHX38⁶	--	82(a)	1 ↔ 1	GL343483.1(371307-391093)
African clawed frog (Xenopus laevis)	Amphibia	CF271376.1²	--	78.92(n)		CF271376.1
zebrafish (Danio rerio)	Actinopterygii	zgc63517²	hypothetical protein MGC63517	77.5(n)		393850 BC063744.1
fruit fly (Drosophila melanogaster)	Insecta	l(1)G0007¹	lethal (1) G0007	62.44(n) 63.67(a)		32373 NM_132719.2 NP_572947.1
worm (Caenorhabditis elegans)	Secernentea	mog-1¹	Protein MOG-1	58.82(n) 61.72(a)		176409 NM_066811.5 NP_499212.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	PRP16(YKR086W)⁴ PRP16¹	DEAH-box RNA helicase involved in second catalytic more⁴ Prp16p¹	51.75(n)¹ 51.31(a)¹		11(599857-603072)⁴ 853961^{1, 4} NP_013012.3¹ NP_013012.1⁴
thale cress (Arabidopsis thaliana)	eudicotyledons	EMB3011¹	pre-mRNA-splicing factor ATP-dependent RNA helicase more	55.46(n) 54.91(a)		831141 NM_121304.5 NP_196805.2
rice (Oryza sativa)	Liliopsida	Os.14760²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	73.99(n)		AK073417.1
E. coli (Escherichia coli)	Gamma proteobacteria	hrpB⁶ hrpA⁶	predicted ATP-dependent helicase	20(a) 18(a)	possible ortholog possible ortholog	Chromosome(162105-164534) Chromosome(1481085-1484987)

ENSEMBL Gene Tree for DHX38 (if available)
TreeFam Gene Tree for DHX38 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DHX38 gene

DHX40² YTHDC2² DHX57² DHX35² DHX9² DHX29² DHX36² DHX30²

TDRD9² DHX33² DHX16² DHX8²

10 SIMAP similar genes for DHX38 using alignment to 9 protein entries: PRP16_HUMAN (see all proteins):

DHX16 DHX15 DHX8 DHX35 DHX33 DKFZp762F2011

DHX40 DHX32 DQX1 DHX34

DHX38 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3764311^1,2	C,F,A,H,	--	72125617(+)	`TTCTTG/CGTGTG`	4	--	us2k¹ int¹		15		NS EA NA WA CSA	794
rs148605158^1,2		--	72125637(+)	`AGGTGC/TACCTC`	4	--	int¹ us2k¹		0	--	--	--	--
rs142074552^1,2		--	72125638(+)	`GGTGCA/CCCTCA`	4	--	int¹ us2k¹		0	--	--	--	--
rs3764312^1,2	C,F,A,H,	--	72125733(+)	`CTAATA/CCAACC`	4	--	int¹ us2k¹		27		EA NS NA WA CSA	3922
rs112261620^1,2	C,	--	72125849(+)	`ATAATC/ATATTT`	4	--	int¹ us2k¹		1		NA	2
rs79680841^1,2	F,	--	72125914(+)	`TTTGTG/AGTCAT`	4	--	int¹ us2k¹		2		NA EA	240
rs12708926^1,2	C,A,	--	72126063(+)	`AGCACT/CTTGGG`	4	--	int¹ us2k¹		4		NA WA	126
rs12708927^1,2	C,A,	--	72126165(+)	`TTAGCC/TGGGCG`	4	--	int¹ us2k¹		5		NA WA	128
rs152826^1,2	C,A,H,	--	72126180(-)	`TGGCAC/TCTGCC`	4	--	us2k¹ int¹		17		NS EA NA WA CSA	789
rs12445586^1,2	C,F,A,H,	--	72126276(+)	`CACTGC/TACTCC`	4	--	int¹ us2k¹		8		NA WA EA	368

HapMap Linkage Disequilibrium report for DHX38 (72127461 - 72146811 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DHX38
1 CNV: 4011

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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DHX38 for disorders           About GeneDecksing

OMIM gene information: 605584    OMIM disorders: --

1 disease for DHX38:    About MalaCards

north american indian childhood cirrhosis

Export disorders for DHX38 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DHX38 gene, integrated from 9 sources (see all 39):
(articles sorted by number of sources associating them with DHX38)

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Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing. (PubMed id 9524131)^{1, 2, 3} Zhou Z. and Reed R. (1998)
Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)^{1, 2, 3} Nagase T....Nomura N. (1996)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)^{1, 2} Jurica M.S.... Moore M.J. (2002)
Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)^{1, 2} Loftus B.J.... Adams M.D. (1999)
PRP16, a DEAH-box RNA helicase, is recruited to the spliceosome primarily via its nonconserved N-terminal domain. (PubMed id 9769096)^{1, 9} Wang Y. and Guthrie C. (1998)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Novel Loci for metabolic networks and multi-tissue exp ression studies reveal genes for atherosclerosis. (PubMed id 22916037)¹ Inouye M....de Bakker P.I. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9785	HGNC: 17211	AceView: DHX38	Ensembl:ENSG00000140829	euGenes: HUgn9785
ECgene: DHX38	Kegg: 9785	H-InvDB: DHX38

(According to HUGE)
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HUGE: KIAA0224

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DHX38	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DHX38 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DHX38 gene:
Search GeneIP for patents involving DHX38

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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DEAH (Asp-Glu-Ala-His) box polypeptide 38

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DHX38 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 38

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