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Aliases for DHX38 Gene

Aliases for DHX38 Gene

  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 38 2 3
  • DDX38 3 4 6
  • PRP16 3 4 6
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 38 2 3
  • ATP-Dependent RNA Helicase DHX38 3 4
  • DEAH Box Protein 38 3 4
  • Pre-MRNA Splicing Factor ATP-Dependent RNA Helicase PRP16 3
  • Pre-MRNA-Splicing Factor ATP-Dependent RNA Helicase PRP16 3
  • PRP16 Homolog Of S.Cerevisiae 3
  • EC 4
  • KIAA0224 4
  • EC 3.6.1 63
  • PRPF16 3

External Ids for DHX38 Gene

Previous HGNC Symbols for DHX38 Gene

  • DDX38

Previous GeneCards Identifiers for DHX38 Gene

  • GC16P071863
  • GC16P071904
  • GC16P071903
  • GC16P070685
  • GC16P057894

Summaries for DHX38 Gene

Entrez Gene Summary for DHX38 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD/H box family of splicing factors. This protein resembles yeast Prp16 more closely than other DEAD/H family members. It is an ATPase and essential for the catalytic step II in pre-mRNA splicing process. [provided by RefSeq, Jul 2008]

GeneCards Summary for DHX38 Gene

DHX38 (DEAH (Asp-Glu-Ala-His) Box Polypeptide 38) is a Protein Coding gene. Among its related pathways are Gene Expression and Spliceosome. GO annotations related to this gene include nucleic acid binding and ATP-dependent helicase activity. An important paralog of this gene is DHX40.

UniProtKB/Swiss-Prot for DHX38 Gene

  • Probable ATP-binding RNA helicase involved in pre-mRNA splicing

Gene Wiki entry for DHX38 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX38 Gene

Genomics for DHX38 Gene

Regulatory Elements for DHX38 Gene

Genomic Location for DHX38 Gene

72,093,562 bp from pter
72,112,912 bp from pter
19,351 bases
Plus strand

Genomic View for DHX38 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHX38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX38 Gene

Proteins for DHX38 Gene

  • Protein details for DHX38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16
    Protein Accession:
    Secondary Accessions:
    • B4DVG8
    • D3DWS7
    • O75212
    • Q96HN7

    Protein attributes for DHX38 Gene

    1227 amino acids
    Molecular mass:
    140503 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.
    • Sequence=BAA13213.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DHX38 Gene


neXtProt entry for DHX38 Gene

Proteomics data for DHX38 Gene at MOPED

Post-translational modifications for DHX38 Gene

  • Ubiquitination at Lys829
  • Modification sites at PhosphoSitePlus

Other Protein References for DHX38 Gene

Domains for DHX38 Gene

Gene Families for DHX38 Gene

  • DHX :DEAH-boxes

Graphical View of Domain Structure for InterPro Entry



  • Q92620
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.
genes like me logo Genes that share domains with DHX38: view

Function for DHX38 Gene

Molecular function for DHX38 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: Probable ATP-binding RNA helicase involved in pre-mRNA splicing

Enzyme Numbers (IUBMB) for DHX38 Gene

Gene Ontology (GO) - Molecular Function for DHX38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity --
GO:0005515 protein binding IPI 22365833
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DHX38: view

Phenotypes for DHX38 Gene

GenomeRNAi human phenotypes for DHX38:
genes like me logo Genes that share phenotypes with DHX38: view

Animal Model Products

CRISPR Products

miRNA for DHX38 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DHX38

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DHX38 Gene

Localization for DHX38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX38 Gene

Subcellular locations from

Jensen Localization Image for DHX38 Gene COMPARTMENTS Subcellular localization image for DHX38 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for DHX38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 9524131
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA --
GO:0016020 membrane IDA 19946888
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with DHX38: view

Pathways for DHX38 Gene

genes like me logo Genes that share pathways with DHX38: view

Gene Ontology (GO) - Biological Process for DHX38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006200 obsolete ATP catabolic process --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006406 mRNA export from nucleus TAS --
genes like me logo Genes that share ontologies with DHX38: view

Transcripts for DHX38 Gene

Unigene Clusters for DHX38 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 38:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DHX38

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX38 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^
SP1: - - - -
SP3: - - - -
SP5: -
SP11: - - - - -
SP12: -
SP13: -

ExUns: 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b · 24c ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29a · 29b · 29c
SP1: - - -
SP2: - -
SP7: -
SP10: -

Relevant External Links for DHX38 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHX38 Gene

mRNA expression in normal human tissues for DHX38 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHX38 Gene

SOURCE GeneReport for Unigene cluster for DHX38 Gene Hs.151218

genes like me logo Genes that share expressions with DHX38: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DHX38 Gene

Orthologs for DHX38 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX38 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DHX38 35
  • 99.4 (n)
  • 99.76 (a)
DHX38 36
  • 100 (a)
(Bos Taurus)
Mammalia DHX38 35
  • 91.36 (n)
  • 96.98 (a)
DHX38 36
  • 95 (a)
(Canis familiaris)
Mammalia DHX38 35
  • 91.82 (n)
  • 97.8 (a)
DHX38 36
  • 98 (a)
(Mus musculus)
Mammalia Dhx38 35
  • 89.76 (n)
  • 96.74 (a)
Dhx38 16
Dhx38 36
  • 97 (a)
(Monodelphis domestica)
Mammalia DHX38 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia DHX38 36
  • 88 (a)
(Rattus norvegicus)
Mammalia Dhx38 35
  • 90.99 (n)
  • 97.52 (a)
(Gallus gallus)
Aves DHX38 35
  • 79.96 (n)
  • 90.54 (a)
DHX38 36
  • 90 (a)
(Anolis carolinensis)
Reptilia DHX38 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx38 35
  • 73.36 (n)
  • 84.73 (a)
(Danio rerio)
Actinopterygii dhx38 35
  • 74.33 (n)
  • 82.08 (a)
dhx38 36
  • 80 (a)
zgc63517 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008528 35
  • 68.29 (n)
  • 71.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(1)G0007 35
  • 65.75 (n)
  • 68.15 (a)
l(1)G0007 36
  • 60 (a)
(Caenorhabditis elegans)
Secernentea mog-1 35
  • 59.5 (n)
  • 63.34 (a)
mog-1 36
  • 58 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR224W 35
  • 55.92 (n)
  • 56.06 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP16 35
  • 52.49 (n)
  • 52.8 (a)
PRP16 36
  • 40 (a)
PRP16 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A07733g 35
  • 54.27 (n)
  • 56.29 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons EMB3011 35
  • 57.45 (n)
  • 58.26 (a)
(Hordeum vulgare)
Liliopsida Hv.4635 35
(Oryza sativa)
Liliopsida Os.14760 35
Os07g0508000 35
  • 59.3 (n)
  • 59.07 (a)
(Triticum aestivum)
Liliopsida Ta.25749 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02728 35
  • 61.52 (n)
  • 61.05 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes prp16 35
  • 54.97 (n)
  • 58.19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 64 (a)
Species with no ortholog for DHX38:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DHX38 Gene

Gene Tree for DHX38 (if available)
Gene Tree for DHX38 (if available)

Paralogs for DHX38 Gene

Paralogs for DHX38 Gene

genes like me logo Genes that share paralogs with DHX38: view

Variants for DHX38 Gene

Sequence variations from dbSNP and Humsavar for DHX38 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs6680 -- 72,112,671(+) AGTTC(C/T)TCCAT utr-variant-3-prime
rs7940 -- 72,112,542(+) GTCCT(C/G)AGCCT utr-variant-3-prime
rs8257 -- 72,112,739(+) AGCGG(A/G)AGGTG utr-variant-3-prime
rs30432 -- 72,113,287(-) CTGGT(A/G)ATTCT downstream-variant-500B
rs30433 -- 72,111,505(-) ccagt(A/G)aggat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHX38 Gene

Variant ID Type Subtype PubMed ID
nsv7285 OTHER Inversion 18451855
nsv833273 CNV Loss 17160897
dgv898e1 CNV Complex 17122850
nsv428329 CNV Gain 18775914
esv2714683 CNV Deletion 23290073

Relevant External Links for DHX38 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX38 Gene

Disorders for DHX38 Gene

No disorders were found for DHX38 Gene.

No data available for UniProtKB/Swiss-Prot for DHX38 Gene

Publications for DHX38 Gene

  1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4
  2. Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing. (PMID: 9524131) Zhou Z. … Reed R. (EMBO J. 1998) 2 3 4
  3. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus B.J. … Adams M.D. (Genomics 1999) 3 4
  4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4
  5. PRP16, a DEAH-box RNA helicase, is recruited to the spliceosome primarily via its nonconserved N-terminal domain. (PMID: 9769096) Wang Y. … Guthrie C. (RNA 1998) 3 23

Products for DHX38 Gene

Sources for DHX38 Gene

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