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DHX38 Gene

protein-coding   GIFtS: 62
GCID: GC16P072127

DEAH (Asp-Glu-Ala-His) Box Polypeptide 38

(Previous name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 38)
(Previous symbol: DDX38)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEAH (Asp-Glu-Ala-His) Box Polypeptide 381 2     Pre-MRNA Splicing Factor ATP-Dependent RNA Helicase PRP162
DDX381 2 3 5     Pre-MRNA-Splicing Factor ATP-Dependent RNA Helicase PRP162
PRP162 3 5     PRP16 Homolog Of S.Cerevisiae2
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 381 2     EC 3.6.4.133
ATP-Dependent RNA Helicase DHX382 3     KIAA02243
DEAH Box Protein 382 3     EC 3.6.18
PRPF162     

External Ids:    HGNC: 172111   Entrez Gene: 97852   Ensembl: ENSG000001408297   OMIM: 6055845   UniProtKB: Q926203   

Export aliases for DHX38 gene to outside databases

Previous GC identifers: GC16P071863 GC16P071904 GC16P071903 GC16P070685 GC16P057894


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DHX38 Gene:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They
are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their
distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis,
and cellular growth and division. The protein encoded by this gene is a member of the DEAD/H box family of
splicing factors. This protein resembles yeast Prp16 more closely than other DEAD/H family members. It is an
ATPase and essential for the catalytic step II in pre-mRNA splicing process. (provided by RefSeq, Jul 2008)

GeneCards Summary for DHX38 Gene:
DHX38 (DEAH (Asp-Glu-Ala-His) box polypeptide 38) is a protein-coding gene. GO annotations related to this gene include ATP-dependent helicase activity and nucleic acid binding. An important paralog of this gene is DHX40.

UniProtKB/Swiss-Prot: PRP16_HUMAN, Q92620
Function: Probable ATP-binding RNA helicase involved in pre-mRNA splicing

Gene Wiki entry for DHX38 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DHX38 gene promoter:
         AhR   C/EBPbeta   NF-1   NF-1/L   p53   CUTL1   GATA-1   Arnt   MZF-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDHX38 promoter sequence
   Search Chromatin IP Primers for DHX38

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DHX38


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22   Ensembl cytogenetic band:  16q22.2   HGNC cytogenetic band: 16q22

DHX38 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHX38 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P072127:  view genomic region     (about GC identifiers)

Start:
72,127,461 bp from pter      End:
72,146,811 bp from pter
Size:
19,351 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PRP16_HUMAN, Q92620 (See protein sequence)
Recommended Name: Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16  
Size: 1227 amino acids; 140503 Da
Subunit: Identified in the spliceosome C complex
Sequence caution: Sequence=BAA13213.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: D3DWS7 O75212 Q96HN7

Explore the universe of human proteins at neXtProt for DHX38: NX_Q92620

Explore proteomics data for DHX38 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys829
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DHX38 (Q92620) (see all 11)
     TNIAETS  IKYMTDG  TVPEIQR  IRFEDCT 


    See DHX38 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_054722.2  
    ENSEMBL proteins: 
     ENSP00000268482   ENSP00000455939   ENSP00000462149   ENSP00000457887   ENSP00000462965  
     ENSP00000462397   ENSP00000454521   ENSP00000437898  
    Reactome Protein details: Q92620

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DHX38

     
    Search eBioscience for Proteins for DHX38 

     
    antibodies-online proteins for DHX38 (2 products) 

     
    antibodies-online peptides for DHX38

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    antibodies-online antibodies for DHX38 (19 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DHX: DEAH-boxes

    Selected InterPro protein domains (see all 7):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR002464 DNA/RNA_helicase_DEAH_CS
     IPR007502 Helicase-assoc_dom
     IPR011709 DUF1605
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q92620

    ProtoNet protein and cluster: Q92620

    2 Blocks protein domains:
    IPB002464 ATP-dependent helicase
    IPB007502 Helicase-associated region


    UniProtKB/Swiss-Prot: PRP16_HUMAN, Q92620
    Similarity: Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Find genes that share domains with DHX38           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRP16_HUMAN, Q92620
    Function: Probable ATP-binding RNA helicase involved in pre-mRNA splicing
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0004386helicase activity ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0008026ATP-dependent helicase activity IEA--
         
    Find genes that share ontologies with DHX38           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DHX38:
     Synthetic lethal with Ras 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target DHX38:
    hsa-mir-16-5p (MIRT051303), hsa-mir-484 (MIRT041970), hsa-mir-34a-5p (MIRT025390), hsa-mir-125b-5p (MIRT046022)

    Block miRNA regulation of human, mouse, rat DHX38 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate DHX38:
    hsa-miR-520d-5p hsa-miR-466 hsa-miR-513a-3p hsa-miR-524-5p hsa-miR-3941
    SwitchGear 3'UTR luciferase reporter plasmidDHX38 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DHX38
    Predesigned siRNA for gene silencing in human, mouse, rat DHX38

    Gene Editing
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX38
    Addgene plasmids for DHX38 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX38


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRP16_HUMAN, Q92620: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS9524131
    GO:0005654nucleoplasm TAS--
    GO:0071013catalytic step 2 spliceosome IDA11991638

    Find genes that share ontologies with DHX38           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DHX38 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.80
    mRNA 3-end processing0.80
    Cleavage of Growing Transcript in the Termination Region0.80
    3Transport of Mature Transcript to Cytoplasm
    Transport of Mature mRNA derived from an Intron-Containing Transcript0.93
    Transport of Mature Transcript to Cytoplasm0.93
    4Formation of RNA Pol II elongation complex
    RNA Polymerase II Transcription0.60
    5Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with DHX38           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for DHX38
        mRNA processing

    4 Reactome Pathways for DHX38
        mRNA Splicing - Major Pathway
    Transport of Mature mRNA derived from an Intron-Containing Transcript
    mRNA 3'-end processing
    Cleavage of Growing Transcript in the Termination Region


    1 Kegg Pathway  (Kegg details for DHX38):
        Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DHX38
    Interactions:

        Search GeneGlobe Interaction Network for DHX38

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DHX38 (Q926201, 2, 3 ENSP000002684824) via UniProtKB, MINT, STRING, and/or I2D (see all 250)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DHX16O602311, 2, 3EBI-1043041,EBI-311446 MINT-8331635 MINT-8337640 I2D: score=1 
    ENSG00000206486O602311, 2, 3EBI-1043041,EBI-311446 MINT-8331635 MINT-8337640 I2D: score=1 
    ENSG00000226171O602311, 2, 3EBI-1043041,EBI-311446 MINT-8331635 MINT-8337640 I2D: score=1 
    ENSG00000231377O602311, 2, 3EBI-1043041,EBI-311446 MINT-8331635 MINT-8337640 I2D: score=1 
    ENSG00000233049O602311, 2, 3EBI-1043041,EBI-311446 MINT-8331635 MINT-8337640 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006406mRNA export from nucleus TAS--
    GO:0008380RNA splicing TAS--

    Find genes that share ontologies with DHX38           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DHX38 (PRP16)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DHX38 gene: 
    NM_014003.3  

    Unigene Cluster for DHX38:

    DEAH (Asp-Glu-Ala-His) box polypeptide 38
    Hs.151218  [show with all ESTs]
    Unigene Representative Sequence: NM_014003
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000268482(uc010cgn.1 uc002fcb.3 uc010vmp.2) ENST00000566794
    ENST00000579387 ENST00000566489 ENST00000564307 ENST00000563650 ENST00000566329
    ENST00000569935 ENST00000562774 ENST00000563819 ENST00000564622 ENST00000567552
    ENST00000567142 ENST00000569952 ENST00000536867
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate DHX38:
    hsa-miR-520d-5p hsa-miR-466 hsa-miR-513a-3p hsa-miR-524-5p hsa-miR-3941
    SwitchGear 3'UTR luciferase reporter plasmidDHX38 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DHX38
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    GenScript: all cDNA clones in your preferred vector: DHX38 (NM_014003)
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    Addgene plasmids for DHX38 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for DHX38
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DHX38
      QuantiTect SYBR Green Assays in human, mouse, rat DHX38
      QuantiFast Probe-based Assays in human, mouse, rat DHX38

    Additional mRNA sequence: 

    AF038391.1 AK291634.1 AK293776.1 AK297269.1 AK297791.1 AK301074.1 AK309391.1 AK311169.1 
    BC004235.2 BC008340.1 D86977.1 

    Selected DOTS entries (see all 27):

    DT.100786705  DT.443498  DT.100786706  DT.91953949  DT.120676149  DT.91841288  DT.120676294  DT.92459430 
    DT.100786697  DT.120676181  DT.406538  DT.92459420  DT.100655413  DT.100786702  DT.120676182  DT.120676163 
    DT.120676180  DT.95129394  DT.97771970  DT.100645390  DT.120676084  DT.75138770  DT.95129391  DT.100652587 

    Selected AceView cDNA sequences (see all 269):

    BM828434 AA454703 BU617072 BQ949782 BM695138 CF265199 BG005257 CA436837 
    BQ948475 AW512345 BE076845 AI357632 CA749025 BU151679 BQ070078 CB153296 
    BG748840 AW135869 NM_014003 AI439353 BQ213060 AA810985 AA782175 BQ932850 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DHX38 (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^
    SP1:                                      -                                   -     -                                                                       -   
    SP2:                                                                                                                                                            
    SP3:                                      -                                   -     -     -                                                                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                        -   

    ExUns: 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b · 24c ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29a · 29b · 29c
    SP1:        -     -                                                                                         -                                                   
    SP2:                                                                                                        -                       -                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for DHX38

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    DHX38 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGGGAGCGG
    DHX38 Expression
    About this image


    DHX38 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Peripheral blood-derived hematopoietic stem cells (family)
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
    DHX38 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DHX38 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.151218
        Custom PCR Arrays for DHX38
    Primer
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    OriGene qPCR primer pairs and template standards for DHX38
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DHX38 gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dhx381 , 5 DEAH (Asp-Glu-Ala-His) box polypeptide 381, 5 89.76(n)1
    96.74(a)1
      8 (57.09 cM)5
    643401  NM_178380.11  NP_848467.11 
     1095480245 
    chicken
    (Gallus gallus)
    Aves DHX381 DEAH (Asp-Glu-Ala-His) box polypeptide 38 79.96(n)
    90.54(a)
      415875  NM_001030582.1  NP_001025753.1 
    lizard
    (Anolis carolinensis)
    Reptilia DHX386
    DEAH (Asp-Glu-Ala-His) box polypeptide 38
    80(a)
    1 ↔ 1
    GL343483.1(371307-394056)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF271376.12   -- 78.92(n)    CF271376.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc635172 hypothetical protein MGC63517 77.5(n)   393850  BC063744.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(1)G00071 lethal (1) G0007 65.75(n)
    68.15(a)
      32373  NM_132719.2  NP_572947.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mog-11 mog-1 59.5(n)
    63.34(a)
      176409  NM_066811.6  NP_499212.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRP16(YKR086W)4
    PRP161
    DEAH-box RNA helicase involved in second catalytic more4
    PRP161
    52.49(n)1
    52.8(a)1
      11(599857-603072)4
    8539611, 4  NP_013012.31  NP_013012.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EMB30111 EMB3011 57.45(n)
    58.26(a)
      831141  NM_121304.5  NP_196805.2 
    rice
    (Oryza sativa)
    Liliopsida Os.147602 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.99(n)    AK073417.1 


    ENSEMBL Gene Tree for DHX38 (if available)
    TreeFam Gene Tree for DHX38 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DHX38 gene
    DHX402  
    9 SIMAP similar genes for DHX38 using alignment to 9 protein entries:     PRP16_HUMAN (see all proteins):
    DHX16    DHX15    DHX8    DHX35    DHX33    DKFZp762F2011
    DHX40    DHX32    DQX1

    Find genes that share paralogs with DHX38           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DHX38 (see all 541)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1921184101,2
    C--72130221(+) CTGGCG/TTCCCT 2 A syn10--------
    rs1505929831,2
    C,F--72130232(+) GAAACG/AGAGAG 2 /Q /R mis11Minor allele frequency- A:0.00NA 4550
    rs1473651581,2
    C,F--72130254(+) AAGGAA/C/TGATGG 3 E D mis1 syn11NA 4550
    rs1845113491,2
    C--72130255(+) AGGACA/GATGGG 2 N D mis10--------
    rs2021984651,2
    --72130351(+) GTGACA/CAGGCT 2 K Q mis10--------
    rs1899570771,2
    --72130480(+) AGAGCC/TTTATG 1 -- int10--------
    rs99269271,2
    C,F,A,H--72130556(+) AAGACT/GAGATG 1 -- int129Minor allele frequency- G:0.47NA MN EA NS WA CSA 2873
    rs1929835041,2
    C--72130735(+) GTCTGC/TTCGGG 2 A V mis10--------
    rs1395471161,2
    C,F--72130772(+) GTGAGC/TGAAGA 2 S syn11Minor allele frequency- T:0.00NA 4552
    rs2005013131,2
    C--72130806(+) GAGAGC/TGGGAG 2 R W mis10--------

    HapMap Linkage Disequilibrium report for DHX38 (72127461 - 72146811 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for DHX38:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714683CNV Deletion23290073
    nsv833273CNV Loss17160897
    nsv428329CNV Gain18775914
    dgv898e1CNV Complex17122850
    nsv7285OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DHX38
    DNA2.0 Custom Variant and Variant Library Synthesis for DHX38

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605584    OMIM disorders: --


    Find genes that share disorders with DHX38           About GenesLikeMe


    Export disorders for DHX38 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DHX38 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with DHX38)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing. (PubMed id 9524131)1, 2, 3 Zhou Z. and Reed R. (EMBO J. 1998)
    2. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2, 3 Nagase T.... Nomura N. (DNA Res. 1996)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    5. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2 Loftus B.J.... Adams M.D. (Genomics 1999)
    6. PRP16, a DEAH-box RNA helicase, is recruited to the spliceosome primarily via its nonconserved N-terminal domain. (PubMed id 9769096)1, 9 Wang Y. and Guthrie C. (RNA 1998)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis. (PubMed id 22916037)1 Inouye M....de Bakker P.I. (PLoS Genet. 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9785 HGNC: 17211 AceView: DHX38 Ensembl:ENSG00000140829 euGenes: HUgn9785
    ECgene: DHX38 Kegg: 9785 H-InvDB: DHX38

    (According to HUGE)
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    HUGE: KIAA0224

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DHX38 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DHX38 gene:
    Search GeneIP for patents involving DHX38

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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