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Aliases for DHX38 Gene

Aliases for DHX38 Gene

  • DEAH-Box Helicase 38 2 3
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 38 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 38 2 3
  • ATP-Dependent RNA Helicase DHX38 3 4
  • DEAH Box Protein 38 3 4
  • DDX38 3 4
  • PRP16 3 4
  • Pre-MRNA Splicing Factor ATP-Dependent RNA Helicase PRP16 3
  • PRP16 Homolog Of S.Cerevisiae 3
  • EC 3.6.4.13 4
  • KIAA0224 4
  • EC 3.6.1 63
  • PRPF16 3

External Ids for DHX38 Gene

Previous HGNC Symbols for DHX38 Gene

  • DDX38

Previous GeneCards Identifiers for DHX38 Gene

  • GC16P071863
  • GC16P071904
  • GC16P071903
  • GC16P070685
  • GC16P057894

Summaries for DHX38 Gene

Entrez Gene Summary for DHX38 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD/H box family of splicing factors. This protein resembles yeast Prp16 more closely than other DEAD/H family members. It is an ATPase and essential for the catalytic step II in pre-mRNA splicing process. [provided by RefSeq, Jul 2008]

GeneCards Summary for DHX38 Gene

DHX38 (DEAH-Box Helicase 38) is a Protein Coding gene. Diseases associated with DHX38 include retinitis pigmentosa. Among its related pathways are Gene Expression and Transport of Mature Transcript to Cytoplasm. GO annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DHX16.

UniProtKB/Swiss-Prot for DHX38 Gene

  • Probable ATP-binding RNA helicase involved in pre-mRNA splicing.

Gene Wiki entry for DHX38 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX38 Gene

Genomics for DHX38 Gene

Regulatory Elements for DHX38 Gene

Promoters for DHX38 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DHX38 on UCSC Golden Path with GeneCards custom track

Genomic Location for DHX38 Gene

Chromosome:
16
Start:
72,093,562 bp from pter
End:
72,112,912 bp from pter
Size:
19,351 bases
Orientation:
Plus strand

Genomic View for DHX38 Gene

Genes around DHX38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX38 Gene

Proteins for DHX38 Gene

  • Protein details for DHX38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92620-PRP16_HUMAN
    Recommended name:
    Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16
    Protein Accession:
    Q92620
    Secondary Accessions:
    • B4DVG8
    • D3DWS7
    • O75212
    • Q96HN7

    Protein attributes for DHX38 Gene

    Size:
    1227 amino acids
    Molecular mass:
    140503 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.
    SequenceCaution:
    • Sequence=BAA13213.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DHX38 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHX38 Gene

Proteomics data for DHX38 Gene at MOPED

Post-translational modifications for DHX38 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHX38 Gene

Domains & Families for DHX38 Gene

Gene Families for DHX38 Gene

Graphical View of Domain Structure for InterPro Entry

Q92620

UniProtKB/Swiss-Prot:

PRP16_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.
genes like me logo Genes that share domains with DHX38: view

Function for DHX38 Gene

Molecular function for DHX38 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Probable ATP-binding RNA helicase involved in pre-mRNA splicing.

Enzyme Numbers (IUBMB) for DHX38 Gene

Gene Ontology (GO) - Molecular Function for DHX38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008026 ATP-dependent helicase activity IEA --
genes like me logo Genes that share ontologies with DHX38: view
genes like me logo Genes that share phenotypes with DHX38: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DHX38

miRNA for DHX38 Gene

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHX38 Gene

Localization for DHX38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX38 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHX38 Gene COMPARTMENTS Subcellular localization image for DHX38 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for DHX38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DHX38: view

Pathways & Interactions for DHX38 Gene

genes like me logo Genes that share pathways with DHX38: view

Gene Ontology (GO) - Biological Process for DHX38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006406 mRNA export from nucleus TAS --
GO:0031124 mRNA 3-end processing TAS --
genes like me logo Genes that share ontologies with DHX38: view

No data available for SIGNOR curated interactions for DHX38 Gene

Drugs & Compounds for DHX38 Gene

(1) Drugs for DHX38 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DHX38 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DHX38: view

Transcripts for DHX38 Gene

Unigene Clusters for DHX38 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 38:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX38 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^
SP1: - - - -
SP2:
SP3: - - - -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: - - - - -
SP12: -
SP13: -
SP14:

ExUns: 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b · 24c ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29a · 29b · 29c
SP1: - - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:

Relevant External Links for DHX38 Gene

GeneLoc Exon Structure for
DHX38
ECgene alternative splicing isoforms for
DHX38

Expression for DHX38 Gene

mRNA expression in normal human tissues for DHX38 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DHX38 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.8) and CD8 Tcells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHX38 Gene



SOURCE GeneReport for Unigene cluster for DHX38 Gene Hs.151218

genes like me logo Genes that share expression patterns with DHX38: view

Protein tissue co-expression partners for DHX38 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DHX38 Gene

Orthologs for DHX38 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX38 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DHX38 35
  • 91.36 (n)
  • 96.98 (a)
DHX38 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DHX38 35
  • 91.82 (n)
  • 97.8 (a)
DHX38 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dhx38 35
  • 89.76 (n)
  • 96.74 (a)
Dhx38 16
Dhx38 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DHX38 35
  • 99.4 (n)
  • 99.76 (a)
DHX38 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dhx38 35
  • 90.99 (n)
  • 97.52 (a)
oppossum
(Monodelphis domestica)
Mammalia DHX38 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DHX38 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves DHX38 35
  • 79.96 (n)
  • 90.54 (a)
DHX38 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHX38 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx38 35
  • 73.36 (n)
  • 84.73 (a)
zebrafish
(Danio rerio)
Actinopterygii dhx38 35
  • 74.33 (n)
  • 82.08 (a)
zgc63517 35
dhx38 36
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008528 35
  • 68.29 (n)
  • 71.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(1)G0007 35
  • 65.75 (n)
  • 68.15 (a)
l(1)G0007 36
  • 60 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mog-1 35
  • 59.5 (n)
  • 63.34 (a)
mog-1 36
  • 58 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR224W 35
  • 55.92 (n)
  • 56.06 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A07733g 35
  • 54.27 (n)
  • 56.29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP16 35
  • 52.49 (n)
  • 52.8 (a)
PRP16 36
  • 40 (a)
OneToMany
PRP16 38
thale cress
(Arabidopsis thaliana)
eudicotyledons EMB3011 35
  • 57.45 (n)
  • 58.26 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.4635 35
rice
(Oryza sativa)
Liliopsida Os.14760 35
Os07g0508000 35
  • 59.3 (n)
  • 59.07 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.25749 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02728 35
  • 61.52 (n)
  • 61.05 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes prp16 35
  • 54.97 (n)
  • 58.19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 64 (a)
OneToOne
Species with no ortholog for DHX38:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DHX38 Gene

ENSEMBL:
Gene Tree for DHX38 (if available)
TreeFam:
Gene Tree for DHX38 (if available)

Paralogs for DHX38 Gene

Paralogs for DHX38 Gene

genes like me logo Genes that share paralogs with DHX38: view

Variants for DHX38 Gene

Sequence variations from dbSNP and Humsavar for DHX38 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_015518 -
rs150617 -- 72,105,497(-) ACAGG(A/G)AGGGA intron-variant
rs6680 -- 72,112,671(+) AGTTC(C/T)TCCAT utr-variant-3-prime
rs7940 -- 72,112,542(+) GTCCT(C/G)AGCCT intron-variant, utr-variant-3-prime
rs8257 -- 72,112,739(+) AGCGG(A/G)AGGTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DHX38 Gene

Variant ID Type Subtype PubMed ID
nsv7285 OTHER Inversion 18451855
nsv833273 CNV Loss 17160897
dgv898e1 CNV Complex 17122850
nsv428329 CNV Gain 18775914
esv2714683 CNV Deletion 23290073

Variation tolerance for DHX38 Gene

Residual Variation Intolerance Score: 0.934% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHX38 Gene

HapMap Linkage Disequilibrium report
DHX38
Human Gene Mutation Database (HGMD)
DHX38

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX38 Gene

Disorders for DHX38 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DHX38 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards
Search DHX38 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DHX38

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHX38
genes like me logo Genes that share disorders with DHX38: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DHX38 Gene

Publications for DHX38 Gene

  1. Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing. (PMID: 9524131) Zhou Z. … Reed R. (EMBO J. 1998) 2 3 4 67
  2. PRP16, a DEAH-box RNA helicase, is recruited to the spliceosome primarily via its nonconserved N-terminal domain. (PMID: 9769096) Wang Y. … Guthrie C. (RNA 1998) 3 23
  3. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 2 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for DHX38 Gene

Sources for DHX38 Gene

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