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Aliases for DHX37 Gene

Aliases for DHX37 Gene

  • DEAH-Box Helicase 37 2 3 5
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 37 2 3
  • DEAD/DEAH Box Helicase DDX37 2 3
  • DEAH Box Protein 37 3 4
  • DDX37 3 4
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 37 3
  • Probable ATP-Dependent RNA Helicase DHX37 3
  • EC 3.6.4.13 4
  • KIAA1517 4
  • EC 3.6.1 61

External Ids for DHX37 Gene

Previous HGNC Symbols for DHX37 Gene

  • DDX37

Previous GeneCards Identifiers for DHX37 Gene

  • GC12M125155
  • GC12M123784
  • GC12M123956
  • GC12M123997
  • GC12M125431
  • GC12M122392

Summaries for DHX37 Gene

Entrez Gene Summary for DHX37 Gene

  • This gene encodes a DEAD box protein. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. [provided by RefSeq, Jul 2008]

GeneCards Summary for DHX37 Gene

DHX37 (DEAH-Box Helicase 37) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. GO annotations related to this gene include nucleic acid binding and helicase activity.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX37 Gene

Genomics for DHX37 Gene

Regulatory Elements for DHX37 Gene

Enhancers for DHX37 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G124913 2.2 FANTOM5 Ensembl ENCODE dbSUPER 51.3 +69.9 69949 12.7 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 NCOR2 DHX37 DNAH10OS ENSG00000275389 ENSG00000270130 ENSG00000269938 ENSG00000270061 ENSG00000269997 SCARB1 BRI3BP
GH12G124937 2.1 FANTOM5 Ensembl ENCODE dbSUPER 31.2 +49.6 49614 5.0 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 DHX37 UBC BRI3BP NCOR2 TRD-GTC2-10 RPL22P19
GH12G124427 1.7 Ensembl ENCODE dbSUPER 21.4 +560.4 560384 3.1 CREB3L1 MLX AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF416 ZNF263 EIF2B1 NCOR2 ATP6V0A2 LOC101927415 DHX37 GTF2H3 TCTN2 ENSG00000270130 ENSG00000269938 ENSG00000270061
GH12G124926 1.6 Ensembl ENCODE dbSUPER 14.9 +60.8 60790 3.9 HDGF PKNOX1 MLX CREB3L1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 DHX37 TRF-GAA1-4 RPL22P19
GH12G124764 1.5 Ensembl ENCODE dbSUPER 14.7 +223.2 223228 3.6 HDGF WRNIP1 ARID4B SIN3A ZNF2 ZNF48 GTF3C2 CBX5 ZNF143 ZNF207 DHX37 GC12P124778 ENSG00000279931
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DHX37 on UCSC Golden Path with GeneCards custom track

Promoters for DHX37 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000059015 231 1400 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 BRCA1 ZNF121 SLC30A9 GLIS2 ZNF207

Genomic Location for DHX37 Gene

Chromosome:
12
Start:
124,946,824 bp from pter
End:
124,989,131 bp from pter
Size:
42,308 bases
Orientation:
Minus strand

Genomic View for DHX37 Gene

Genes around DHX37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX37 Gene

Proteins for DHX37 Gene

  • Protein details for DHX37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY37-DHX37_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DHX37
    Protein Accession:
    Q8IY37
    Secondary Accessions:
    • Q9BUI7
    • Q9P211

    Protein attributes for DHX37 Gene

    Size:
    1157 amino acids
    Molecular mass:
    129545 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DHX37 Gene

Selected DME Specific Peptides for DHX37 Gene

Q8IY37:
  • PQFLYEAG
  • TGSGKTTQ

Post-translational modifications for DHX37 Gene

  • Ubiquitination at Lys118 and isoforms=786
  • Modification sites at PhosphoSitePlus

Other Protein References for DHX37 Gene

Domains & Families for DHX37 Gene

Gene Families for DHX37 Gene

Suggested Antigen Peptide Sequences for DHX37 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IY37

UniProtKB/Swiss-Prot:

DHX37_HUMAN :
  • Belongs to the DEAD box helicase family. DEAH subfamily.
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX37: view

Function for DHX37 Gene

Molecular function for DHX37 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.

Enzyme Numbers (IUBMB) for DHX37 Gene

Gene Ontology (GO) - Molecular Function for DHX37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DHX37: view
genes like me logo Genes that share phenotypes with DHX37: view

Animal Model Products

CRISPR Products

miRNA for DHX37 Gene

miRTarBase miRNAs that target DHX37

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHX37 Gene

Localization for DHX37 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHX37 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DHX37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DHX37: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DHX37 Gene

Pathways & Interactions for DHX37 Gene

genes like me logo Genes that share pathways with DHX37: view

Gene Ontology (GO) - Biological Process for DHX37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
GO:0006396 RNA processing IBA --
genes like me logo Genes that share ontologies with DHX37: view

No data available for SIGNOR curated interactions for DHX37 Gene

Drugs & Compounds for DHX37 Gene

(3) Drugs for DHX37 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for DHX37 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DHX37: view

Transcripts for DHX37 Gene

Unigene Clusters for DHX37 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 37:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX37 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^
SP1: - -
SP2: - -
SP3:
SP4: - - -
SP5:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for DHX37 Gene

GeneLoc Exon Structure for
DHX37
ECgene alternative splicing isoforms for
DHX37

Expression for DHX37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHX37 Gene

Protein differential expression in normal tissues from HIPED for DHX37 Gene

This gene is overexpressed in Blymphocyte (20.7), Peripheral blood mononuclear cells (17.8), and CD8 Tcells (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DHX37 Gene



Protein tissue co-expression partners for DHX37 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DHX37 Gene:

DHX37

SOURCE GeneReport for Unigene cluster for DHX37 Gene:

Hs.107382

Evidence on tissue expression from TISSUES for DHX37 Gene

  • Nervous system(4.5)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with DHX37: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHX37 Gene

Orthologs for DHX37 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC452413 34
  • 96.87 (n)
cow
(Bos Taurus)
Mammalia DHX37 34 35
  • 85.12 (n)
dog
(Canis familiaris)
Mammalia DHX37 34 35
  • 84.97 (n)
rat
(Rattus norvegicus)
Mammalia Dhx37 34
  • 81.55 (n)
mouse
(Mus musculus)
Mammalia Dhx37 34 16 35
  • 81.38 (n)
oppossum
(Monodelphis domestica)
Mammalia DHX37 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DHX37 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves DHX37 34 35
  • 68.83 (n)
lizard
(Anolis carolinensis)
Reptilia DHX37 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC734015 34
  • 68.3 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6945 34
zebrafish
(Danio rerio)
Actinopterygii dhx37 34 35
  • 63.28 (n)
wufd11d06 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2549 34
fruit fly
(Drosophila melanogaster)
Insecta kz 34 35
  • 55.99 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002687 34
  • 47.97 (n)
worm
(Caenorhabditis elegans)
Secernentea rha-2 34 35
  • 49.13 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM16 35 37
  • 32 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons FAS4 34
  • 47.91 (n)
rice
(Oryza sativa)
Liliopsida Os02g0736600 34
  • 48.11 (n)
Os.25200 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3778 35
  • 44 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7994 34
Species where no ortholog for DHX37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHX37 Gene

ENSEMBL:
Gene Tree for DHX37 (if available)
TreeFam:
Gene Tree for DHX37 (if available)

Paralogs for DHX37 Gene

No data available for Paralogs for DHX37 Gene

Variants for DHX37 Gene

Sequence variations from dbSNP and Humsavar for DHX37 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000134890 -- 124,963,043(+) TCCTT(C/G)CACCT intron-variant
rs1000171120 -- 124,987,138(+) AGGAG(C/T)TGGGG intron-variant
rs1000365935 -- 124,986,442(+) GCAGG(A/G)GCTCA intron-variant
rs1000376547 -- 124,952,842(+) ACACC(C/G)AGGTG intron-variant, utr-variant-3-prime
rs1000409093 -- 124,953,046(+) CAGCG(A/T)ATGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHX37 Gene

Variant ID Type Subtype PubMed ID
dgv890n106 CNV deletion 24896259
esv1114476 CNV deletion 17803354
esv2746553 CNV deletion 23290073
esv2746554 CNV deletion 23290073
esv3169108 CNV deletion 24192839
esv3549942 CNV deletion 23714750
nsv1144663 CNV deletion 24896259
nsv1149138 CNV deletion 26484159
nsv520994 CNV gain+loss 19592680
nsv560595 CNV gain 21841781

Variation tolerance for DHX37 Gene

Residual Variation Intolerance Score: 96.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.60; 95.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHX37 Gene

Human Gene Mutation Database (HGMD)
DHX37
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DHX37

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX37 Gene

Disorders for DHX37 Gene

Relevant External Links for DHX37

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHX37

No disorders were found for DHX37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX37 Gene

Publications for DHX37 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Repression of rRNA transcription by PARIS contributes to Parkinson's disease. (PMID: 25315684) Kang H. … Shin J.H. (Neurobiol. Dis. 2015) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for DHX37 Gene

Sources for DHX37 Gene

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