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Aliases for DHX37 Gene

Aliases for DHX37 Gene

  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 37 2 3
  • DEAD/DEAH Box Helicase DDX37 2 3
  • DEAH Box Protein 37 3 4
  • DDX37 3 4
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 37 3
  • Probable ATP-Dependent RNA Helicase DHX37 3
  • EC 3.6.4.13 4
  • KIAA1517 4
  • EC 3.6.1 64

External Ids for DHX37 Gene

Previous Symbols for DHX37 Gene

  • DDX37

Summaries for DHX37 Gene

Entrez Gene Summary for DHX37 Gene

  • This gene encodes a DEAD box protein. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. [provided by RefSeq, Jul 2008]

GeneCards Summary for DHX37 Gene

DHX37 (DEAH (Asp-Glu-Ala-His) Box Polypeptide 37) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and ATP-dependent helicase activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX37 Gene

Genomics for DHX37 Gene

Genomic Location for DHX37 Gene

Start:
124,946,824 bp from pter
End:
124,989,122 bp from pter
Size:
42,299 bases
Orientation:
Minus strand

Genomic View for DHX37 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHX37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX37 Gene

Regulatory Elements for DHX37 Gene

Proteins for DHX37 Gene

  • Protein details for DHX37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY37-DHX37_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DHX37
    Protein Accession:
    Q8IY37
    Secondary Accessions:
    • Q9BUI7
    • Q9P211

    Protein attributes for DHX37 Gene

    Size:
    1157 amino acids
    Molecular mass:
    129545 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DHX37 Gene

Proteomics data for DHX37 Gene at MOPED

Selected DME Specific Peptides for DHX37 Gene

Post-translational modifications for DHX37 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys118 and Lys786

Other Protein References for DHX37 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for DHX37 Gene

Gene Families for DHX37 Gene

HGNC:
  • DHX :DEAH-boxes

UniProtKB/Swiss-Prot:

DHX37_HUMAN
Domain:
  • Contains 1 helicase ATP-binding domain.:
    • Q8IY37
  • Contains 1 helicase C-terminal domain.:
    • Q8IY37
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily.:
    • Q8IY37
genes like me logo Genes that share domains with DHX37: view

Function for DHX37 Gene

Molecular function for DHX37 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate

Enzyme Numbers (IUBMB) for DHX37 Gene

Gene Ontology (GO) - Molecular Function for DHX37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity --
GO:0005524 ATP binding IEA --
GO:0044822 poly(A) RNA binding IBA --
genes like me logo Genes that share ontologies with DHX37: view

Phenotypes for DHX37 Gene

GenomeRNAi human phenotypes for DHX37:
genes like me logo Genes that share phenotypes with DHX37: view

miRNA for DHX37 Gene

miRTarBase miRNAs that target DHX37

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DHX37 Gene

Localization for DHX37 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHX37 Gene COMPARTMENTS Subcellular localization image for DHX37 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DHX37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DHX37: view

Pathways for DHX37 Gene

SuperPathways for DHX37 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHX37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IBA --
GO:0006810 transport --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with DHX37: view

No data available for Pathways by source for DHX37 Gene

Transcripts for DHX37 Gene

Unigene Clusters for DHX37 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 37:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHX37 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^
SP1: - -
SP2: - -
SP3:
SP4: - - -
SP5:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for DHX37 Gene

GeneLoc Exon Structure for
DHX37
ECgene alternative splicing isoforms for
DHX37

Expression for DHX37 Gene

mRNA expression in normal human tissues for DHX37 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHX37 Gene

SOURCE GeneReport for Unigene cluster for DHX37 Gene Hs.107382

genes like me logo Genes that share expressions with DHX37: view

Orthologs for DHX37 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC452413 36
  • 96.87 (n)
  • 96.52 (a)
cow
(Bos Taurus)
Mammalia DHX37 36
  • 85.12 (n)
  • 87.1 (a)
DHX37 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DHX37 36
  • 84.97 (n)
  • 87.2 (a)
DHX37 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dhx37 36
  • 81.38 (n)
  • 84.5 (a)
Dhx37 16
Dhx37 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DHX37 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DHX37 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dhx37 36
  • 81.55 (n)
  • 85.2 (a)
chicken
(Gallus gallus)
Aves DHX37 36
  • 68.83 (n)
  • 72.61 (a)
DHX37 37
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHX37 37
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6945 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC734015 36
  • 68.3 (n)
  • 75.44 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2549 36
zebrafish
(Danio rerio)
Actinopterygii dhx37 36
  • 63.28 (n)
  • 65.5 (a)
dhx37 37
  • 66 (a)
OneToOne
wufd11d06 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002687 36
  • 47.97 (n)
  • 35.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta kz 36
  • 55.99 (n)
  • 51.82 (a)
kz 37
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rha-2 36
  • 49.13 (n)
  • 47.29 (a)
rha-2 37
  • 39 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM16 37
  • 32 (a)
OneToOne
ECM16 39
thale cress
(Arabidopsis thaliana)
eudicotyledons FAS4 36
  • 47.91 (n)
  • 43.51 (a)
rice
(Oryza sativa)
Liliopsida Os.25200 36
Os02g0736600 36
  • 48.11 (n)
  • 43.6 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7994 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3778 37
  • 44 (a)
OneToOne
Species with no ortholog for DHX37:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHX37 Gene

ENSEMBL:
Gene Tree for DHX37 (if available)
TreeFam:
Gene Tree for DHX37 (if available)

Paralogs for DHX37 Gene

No data available for Paralogs for DHX37 Gene

Variants for DHX37 Gene

Sequence variations from dbSNP and Humsavar for DHX37 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs12330 -- 124,947,036(+) CTCCC(C/G)CTCCC utr-variant-3-prime
rs1132689 -- 124,946,892(-) GGATT(C/T)TGCTC utr-variant-3-prime
rs3803142 -- 124,947,550(-) GTGCT(A/G)GACGC utr-variant-3-prime, downstream-variant-500B
rs3803143 -- 124,947,444(-) AGGCC(A/G)AGGAG utr-variant-3-prime, downstream-variant-500B
rs3803144 -- 124,947,338(-) GCCAC(C/T)GAGCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DHX37 Gene

Variant ID Type Subtype PubMed ID
nsv520994 CNV Gain+Loss 19592680
esv2746553 CNV Deletion 23290073
esv2746554 CNV Deletion 23290073
esv1114476 CNV Deletion 17803354

Relevant External Links for DHX37 Gene

HapMap Linkage Disequilibrium report
DHX37

Disorders for DHX37 Gene

No disorders were found for DHX37 Gene.

No data available for UniProtKB/Swiss-Prot for DHX37 Gene

Publications for DHX37 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3
  4. The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. (PMID: 20811636) Giannone R.J. … Liu Y. (PLoS ONE 2010) 3
  5. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3

Products for DHX37 Gene

Sources for DHX37 Gene

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