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Aliases for DHX37 Gene

Aliases for DHX37 Gene

  • DEAH-Box Helicase 37 2 3
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 37 2 3 5
  • DEAD/DEAH Box Helicase DDX37 2 3
  • DEAH Box Protein 37 3 4
  • DDX37 3 4
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 37 3
  • EC 3.6.4.13 4
  • KIAA1517 4
  • EC 3.6.1 63

External Ids for DHX37 Gene

Previous HGNC Symbols for DHX37 Gene

  • DDX37

Previous GeneCards Identifiers for DHX37 Gene

  • GC12M125155
  • GC12M123784
  • GC12M123956
  • GC12M123997
  • GC12M125431
  • GC12M122392

Summaries for DHX37 Gene

Entrez Gene Summary for DHX37 Gene

  • This gene encodes a DEAD box protein. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. [provided by RefSeq, Jul 2008]

GeneCards Summary for DHX37 Gene

DHX37 (DEAH-Box Helicase 37) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing. GO annotations related to this gene include nucleic acid binding and helicase activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX37 Gene

Genomics for DHX37 Gene

Regulatory Elements for DHX37 Gene

Enhancers for DHX37 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DHX37 on UCSC Golden Path with GeneCards custom track

Promoters for DHX37 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DHX37 on UCSC Golden Path with GeneCards custom track

Genomic Location for DHX37 Gene

Chromosome:
12
Start:
124,946,824 bp from pter
End:
124,989,131 bp from pter
Size:
42,308 bases
Orientation:
Minus strand

Genomic View for DHX37 Gene

Genes around DHX37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX37 Gene

Proteins for DHX37 Gene

  • Protein details for DHX37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY37-DHX37_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DHX37
    Protein Accession:
    Q8IY37
    Secondary Accessions:
    • Q9BUI7
    • Q9P211

    Protein attributes for DHX37 Gene

    Size:
    1157 amino acids
    Molecular mass:
    129545 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DHX37 Gene

Proteomics data for DHX37 Gene at MOPED

Selected DME Specific Peptides for DHX37 Gene

Post-translational modifications for DHX37 Gene

  • Ubiquitination at Lys 118 and Lys 786
  • Modification sites at PhosphoSitePlus

Other Protein References for DHX37 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for DHX37

Domains & Families for DHX37 Gene

Gene Families for DHX37 Gene

Suggested Antigen Peptide Sequences for DHX37 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IY37

UniProtKB/Swiss-Prot:

DHX37_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DEAH subfamily.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX37: view

Function for DHX37 Gene

Molecular function for DHX37 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.

Enzyme Numbers (IUBMB) for DHX37 Gene

Gene Ontology (GO) - Molecular Function for DHX37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0044822 poly(A) RNA binding IBA --
genes like me logo Genes that share ontologies with DHX37: view
genes like me logo Genes that share phenotypes with DHX37: view

Animal Model Products

miRNA for DHX37 Gene

miRTarBase miRNAs that target DHX37

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHX37 Gene

Localization for DHX37 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHX37 Gene COMPARTMENTS Subcellular localization image for DHX37 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DHX37 Gene

Pathways & Interactions for DHX37 Gene

genes like me logo Genes that share pathways with DHX37: view

Pathways by source for DHX37 Gene

Gene Ontology (GO) - Biological Process for DHX37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with DHX37: view

No data available for SIGNOR curated interactions for DHX37 Gene

Drugs & Compounds for DHX37 Gene

(1) Drugs for DHX37 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DHX37 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DHX37: view

Transcripts for DHX37 Gene

Unigene Clusters for DHX37 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 37:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHX37 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^
SP1: - -
SP2: - -
SP3:
SP4: - - -
SP5:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for DHX37 Gene

GeneLoc Exon Structure for
DHX37
ECgene alternative splicing isoforms for
DHX37

Expression for DHX37 Gene

mRNA expression in normal human tissues for DHX37 Gene

Protein differential expression in normal tissues from HIPED for DHX37 Gene

This gene is overexpressed in Blymphocyte (20.7), Peripheral blood mononuclear cells (17.8), and CD8 Tcells (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHX37 Gene



SOURCE GeneReport for Unigene cluster for DHX37 Gene Hs.107382

genes like me logo Genes that share expression patterns with DHX37: view

Protein tissue co-expression partners for DHX37 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DHX37 Gene

Orthologs for DHX37 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX37 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DHX37 35
  • 85.12 (n)
  • 87.1 (a)
DHX37 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DHX37 35
  • 84.97 (n)
  • 87.2 (a)
DHX37 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dhx37 35
  • 81.38 (n)
  • 84.5 (a)
Dhx37 16
Dhx37 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC452413 35
  • 96.87 (n)
  • 96.52 (a)
rat
(Rattus norvegicus)
Mammalia Dhx37 35
  • 81.55 (n)
  • 85.2 (a)
oppossum
(Monodelphis domestica)
Mammalia DHX37 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DHX37 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves DHX37 35
  • 68.83 (n)
  • 72.61 (a)
DHX37 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHX37 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC734015 35
  • 68.3 (n)
  • 75.44 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6945 35
zebrafish
(Danio rerio)
Actinopterygii dhx37 35
  • 63.28 (n)
  • 65.5 (a)
wufd11d06 35
dhx37 36
  • 66 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2549 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002687 35
  • 47.97 (n)
  • 35.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta kz 35
  • 55.99 (n)
  • 51.82 (a)
kz 36
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rha-2 35
  • 49.13 (n)
  • 47.29 (a)
rha-2 36
  • 39 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM16 36
  • 32 (a)
OneToOne
ECM16 38
thale cress
(Arabidopsis thaliana)
eudicotyledons FAS4 35
  • 47.91 (n)
  • 43.51 (a)
rice
(Oryza sativa)
Liliopsida Os.25200 35
Os02g0736600 35
  • 48.11 (n)
  • 43.6 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7994 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3778 36
  • 44 (a)
OneToOne
Species with no ortholog for DHX37:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHX37 Gene

ENSEMBL:
Gene Tree for DHX37 (if available)
TreeFam:
Gene Tree for DHX37 (if available)

Paralogs for DHX37 Gene

No data available for Paralogs for DHX37 Gene

Variants for DHX37 Gene

Sequence variations from dbSNP and Humsavar for DHX37 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs11057939 - 124,968,569(+) CCTTC(C/T)GGAAG reference, missense
rs35165507 - 124,966,859(+) GAGTC(A/G/T)TTCTG reference, missense
rs35016004 - 124,960,320(+) TTCAA(C/T)GTTGA reference, missense
rs4516060 - 124,953,970(+) GCAGC(C/T)GGCAT reference, synonymous-codon, missense
rs4447263 - 124,950,034(+) AGCTC(C/T)GGTAT downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DHX37 Gene

Variant ID Type Subtype PubMed ID
nsv520994 CNV Gain+Loss 19592680
esv2746553 CNV Deletion 23290073
esv2746554 CNV Deletion 23290073
esv1114476 CNV Deletion 17803354

Variation tolerance for DHX37 Gene

Residual Variation Intolerance Score: 96.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.60; 95.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHX37 Gene

Human Gene Mutation Database (HGMD)
DHX37

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX37 Gene

Disorders for DHX37 Gene

Relevant External Links for DHX37

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHX37

No disorders were found for DHX37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX37 Gene

Publications for DHX37 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for DHX37 Gene

Sources for DHX37 Gene

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