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Aliases for DHX36 Gene

Aliases for DHX36 Gene

  • DEAH-Box Helicase 36 2 3
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 36 2 3 5
  • RNA Helicase Associated With AU-Rich Element ARE 3 4
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 36 2 3
  • DEAH Box Protein 36 3 4
  • MLE-Like Protein 1 3 4
  • G4-Resolvase 1 3 4
  • DDX36 3 4
  • MLEL1 3 4
  • G4R1 3 4
  • RHAU 3 4
  • Probable ATP-Dependent RNA Helicase DHX36 3
  • G4 Resolvase-1 3
  • EC 3.6.4.12 4
  • EC 3.6.4.13 4
  • KIAA1488 4
  • EC 3.6.1 63

External Ids for DHX36 Gene

Previous HGNC Symbols for DHX36 Gene

  • DDX36

Previous GeneCards Identifiers for DHX36 Gene

  • GC03M155275
  • GC03M155314
  • GC03M155476
  • GC03M153990
  • GC03M151389

Summaries for DHX36 Gene

Entrez Gene Summary for DHX36 Gene

  • This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for DHX36 Gene

DHX36 (DEAH-Box Helicase 36) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay and Cytosolic sensors of pathogen-associated DNA. GO annotations related to this gene include nucleic acid binding and transcription regulatory region DNA binding. An important paralog of this gene is DHX29.

UniProtKB/Swiss-Prot for DHX36 Gene

  • Proposed to have a global role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures. Unwinds intramolecular quadruplexes derived from the ZIC1 and the MYC promoters. Binds to quadruplex structures in the promoters of YY1 and ALPL genes and regulates their expression. Binds to telomerase RNA template component (TERC) 5-end (nucleotides 1-43) and unwinds an internal quadruplex formation in TERC 5-end to promote P1 helix formation; the P1 helix acts as a template boundary ensuring accurate reverse transcription and is disrupted by quadruplex formation. May be involved in regulation of telomere length. Plays a role in degradation and deadenylation of mRNAs containing in their 3-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. May play a role in ossification.

Gene Wiki entry for DHX36 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX36 Gene

Genomics for DHX36 Gene

Regulatory Elements for DHX36 Gene

Enhancers for DHX36 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DHX36 on UCSC Golden Path with GeneCards custom track

Promoters for DHX36 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DHX36 on UCSC Golden Path with GeneCards custom track

Genomic Location for DHX36 Gene

Chromosome:
3
Start:
154,272,546 bp from pter
End:
154,324,497 bp from pter
Size:
51,952 bases
Orientation:
Minus strand

Genomic View for DHX36 Gene

Genes around DHX36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX36 Gene

Proteins for DHX36 Gene

  • Protein details for DHX36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2U1-DHX36_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DHX36
    Protein Accession:
    Q9H2U1
    Secondary Accessions:
    • B2RB00
    • Q70JU3
    • Q8IYE5
    • Q9P240

    Protein attributes for DHX36 Gene

    Size:
    1008 amino acids
    Molecular mass:
    114760 Da
    Quaternary structure:
    • Interacts with AGO1, AGO2, PARN, EXOSC3, EXOSC10, HDAC1 and HDAC4.

    Three dimensional structures from OCA and Proteopedia for DHX36 Gene

    Alternative splice isoforms for DHX36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHX36 Gene

Proteomics data for DHX36 Gene at MOPED

Selected DME Specific Peptides for DHX36 Gene

Post-translational modifications for DHX36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHX36 Gene

Antibody Products

Domains & Families for DHX36 Gene

Gene Families for DHX36 Gene

Suggested Antigen Peptide Sequences for DHX36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H2U1

UniProtKB/Swiss-Prot:

DHX36_HUMAN :
  • The RHAU-specific motif (RSM) is required for quadruplex G4-DNA/RNA structure recognition and resolution.
  • Belongs to the DEAD box helicase family. DEAH subfamily.
Domain:
  • The RHAU-specific motif (RSM) is required for quadruplex G4-DNA/RNA structure recognition and resolution.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX36: view

Function for DHX36 Gene

Molecular function for DHX36 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Proposed to have a global role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures. Unwinds intramolecular quadruplexes derived from the ZIC1 and the MYC promoters. Binds to quadruplex structures in the promoters of YY1 and ALPL genes and regulates their expression. Binds to telomerase RNA template component (TERC) 5-end (nucleotides 1-43) and unwinds an internal quadruplex formation in TERC 5-end to promote P1 helix formation; the P1 helix acts as a template boundary ensuring accurate reverse transcription and is disrupted by quadruplex formation. May be involved in regulation of telomere length. Plays a role in degradation and deadenylation of mRNAs containing in their 3-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. May play a role in ossification.

Enzyme Numbers (IUBMB) for DHX36 Gene

Gene Ontology (GO) - Molecular Function for DHX36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001047 core promoter binding IDA 21586581
GO:0042826 histone deacetylase binding ISS --
GO:0044212 transcription regulatory region DNA binding ISS --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with DHX36: view
genes like me logo Genes that share phenotypes with DHX36: view

Animal Models for DHX36 Gene

MGI Knock Outs for DHX36:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DHX36 Gene

Localization for DHX36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX36 Gene

Nucleus. Cytoplasm. Chromosome, telomere. Note=Isoform 1 preferentially localized to the nucleus and isoform 2 localized to the cytoplasm. However, partitioning of cellular localization between the nucleus and cytoplasm is not exclusive, as isoform 1 was also detected in the cytoplasm. Both isoforms were excluded from nucleoli. Localizes to cytoplasmic stress granules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHX36 Gene COMPARTMENTS Subcellular localization image for DHX36 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for DHX36 Gene

Pathways & Interactions for DHX36 Gene

genes like me logo Genes that share pathways with DHX36: view

Gene Ontology (GO) - Biological Process for DHX36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009615 response to virus IEA --
genes like me logo Genes that share ontologies with DHX36: view

No data available for SIGNOR curated interactions for DHX36 Gene

Drugs & Compounds for DHX36 Gene

(1) Drugs for DHX36 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DHX36 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DHX36: view

Transcripts for DHX36 Gene

Unigene Clusters for DHX36 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 36:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHX36 Gene

No ASD Table

Relevant External Links for DHX36 Gene

GeneLoc Exon Structure for
DHX36
ECgene alternative splicing isoforms for
DHX36

Expression for DHX36 Gene

mRNA expression in normal human tissues for DHX36 Gene

Protein differential expression in normal tissues from HIPED for DHX36 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.1), Lymph node (9.8), and Lung (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHX36 Gene



SOURCE GeneReport for Unigene cluster for DHX36 Gene Hs.446270

mRNA Expression by UniProt/SwissProt for DHX36 Gene

Q9H2U1-DHX36_HUMAN
Tissue specificity: Highly expressed in testis.
genes like me logo Genes that share expression patterns with DHX36: view

Protein tissue co-expression partners for DHX36 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DHX36 Gene

Orthologs for DHX36 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX36 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DHX36 35
  • 90.4 (n)
  • 92.55 (a)
DHX36 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DHX36 35
  • 91.02 (n)
  • 93.41 (a)
DHX36 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dhx36 35
  • 88.28 (n)
  • 91.51 (a)
Dhx36 16
Dhx36 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DHX36 35
  • 99.64 (n)
  • 99.6 (a)
DHX36 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dhx36 35
  • 88.27 (n)
  • 91.2 (a)
oppossum
(Monodelphis domestica)
Mammalia DHX36 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
chicken
(Gallus gallus)
Aves DHX36 35
  • 76.04 (n)
  • 82.14 (a)
DHX36 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHX36 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx36 35
  • 72.44 (n)
  • 76.43 (a)
Str.17981 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16610 35
zebrafish
(Danio rerio)
Actinopterygii si:dkey-119o24.1 35
  • 65.25 (n)
  • 69.32 (a)
DHX36 36
  • 65 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008239 35
  • 46.86 (n)
  • 41.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9323 35
  • 47.61 (n)
  • 41.14 (a)
CG9323 36
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 19 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G35920 35
  • 53.27 (n)
  • 47.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToOne
Species with no ortholog for DHX36:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DHX36 Gene

ENSEMBL:
Gene Tree for DHX36 (if available)
TreeFam:
Gene Tree for DHX36 (if available)

Paralogs for DHX36 Gene

Paralogs for DHX36 Gene

(11) SIMAP similar genes for DHX36 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DHX36: view

Variants for DHX36 Gene

Sequence variations from dbSNP and Humsavar for DHX36 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1058299 - 154,315,198(-) ATCAA(A/G)AAAAA reference, missense
rs9438 - 154,301,098(+) ACTGG(C/G)ATCTG reference, missense
rs17853513 - 154,292,617(+) TACTG(A/T)TATTG reference, missense
rs714484 -- 154,282,966(-) GGGTT(C/T)GATTT intron-variant
rs355754 -- 154,306,376(-) TTTCA(A/G)CAGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHX36 Gene

Variant ID Type Subtype PubMed ID
nsv4073 CNV Insertion 18451855

Variation tolerance for DHX36 Gene

Residual Variation Intolerance Score: 2.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.56; 95.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHX36 Gene

HapMap Linkage Disequilibrium report
DHX36
Human Gene Mutation Database (HGMD)
DHX36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX36 Gene

Disorders for DHX36 Gene

Relevant External Links for DHX36

Genetic Association Database (GAD)
DHX36
Human Genome Epidemiology (HuGE) Navigator
DHX36
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHX36

No disorders were found for DHX36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX36 Gene

Publications for DHX36 Gene

  1. Molecular cloning and characterization of human DDX36 and mouse Ddx36 genes, new members of the DEAD/H box superfamily. (PMID: 12198572) Fu J.-J. … Lu G.-X. (Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 2002) 3 4 23 67
  2. The DEXH protein product of the DHX36 gene is the major source of tetramolecular quadruplex G4-DNA resolving activity in HeLa cell lysates. (PMID: 16150737) Vaughn J.P. … Akman S.A. (J. Biol. Chem. 2005) 3 23
  3. Expression research for human DDX36 and mouse Ddx36 gene in the adult testis. (PMID: 12812084) Fu J.J. … Lu G.X. (Yi Chuan Xue Bao 2003) 3 23
  4. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  5. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3

Products for DHX36 Gene

Sources for DHX36 Gene

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