Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DHX36 Gene

protein-coding   GIFtS: 60
GCID: GC03M153990

DEAH (Asp-Glu-Ala-His) Box Polypeptide 36

(Previous name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 36)
(Previous symbol: DDX36)
Microbiology & Infectious Diseases Congress
  Search for DHX36
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DEAH (Asp-Glu-Ala-His) Box Polypeptide 361 2     RNA Helicase Associated With AU-Rich Element ARE2 3
DDX361 2 3     G4R12 5
RHAU2 3 5     KIAA14883 5
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 361 2     G4 Resolvase-12
MLEL12 3     Probable ATP-Dependent RNA Helicase DHX362
DEAH Box Protein 362 3     EC 3.6.4.133
MLE-Like Protein 12 3     EC 3.6.18

External Ids:    HGNC: 144101   Entrez Gene: 1705062   Ensembl: ENSG000001749537   OMIM: 6127675   UniProtKB: Q9H2U13   

Export aliases for DHX36 gene to outside databases

Previous GC identifers: GC03M155275 GC03M155314 GC03M155476 GC03M151389


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DHX36 Gene:
This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino
acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the
deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to
resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously
in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different
isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for DHX36 Gene: 
DHX36 (DEAH (Asp-Glu-Ala-His) box polypeptide 36) is a protein-coding gene. Among its related super-pathways are Immune System and Deadenylation-dependent mRNA decay. GO annotations related to this gene include double-stranded RNA binding and ATP-dependent helicase activity. An important paralog of this gene is DHX29.

UniProtKB/Swiss-Prot: DHX36_HUMAN, Q9H2U1
Function: Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE
sequence element. May function in sex development and spermatogenesis

Gene Wiki entry for DHX36 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DHX36 gene promoter:
         AML1a   Meis-1b   HNF-1A   RORalpha1   Nkx6-1   HNF-1   Meis-1a   LyF-1   Meis-1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDHX36 promoter sequence
   Search SABiosciences Chromatin IP Primers for DHX36

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHX36


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.2   Ensembl cytogenetic band:  3q25.2   HGNC cytogenetic band: 3q25.2

DHX36 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHX36 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M153990:  view genomic region     (about GC identifiers)

Start:
153,990,335 bp from pter      End:
154,042,286 bp from pter
Size:
51,952 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DHX36_HUMAN, Q9H2U1 (See protein sequence)
Recommended Name: Probable ATP-dependent RNA helicase DHX36  
Size: 1008 amino acids; 114760 Da
Subunit: Interacts with AGO1, AGO2, PARN, EXOSC3 and EXOSC10
Subcellular location: Nucleus. Cytoplasm. Note=Isoform 1 preferentially localized to the nucleus and isoform 2
localized to the cytoplasm. However, partitioning of cellular localization between the nucleus and cytoplasm is
not exclusive, as isoform 1 was also detected in the cytoplasm. Both isoforms were excluded from nucleoli
Secondary accessions: B2RB00 Q70JU3 Q8IYE5 Q9P240
Alternative splicing: 3 isoforms:  Q9H2U1-1   Q9H2U1-2   Q9H2U1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DHX36: NX_Q9H2U1

Explore proteomics data for DHX36 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H2U1

  • 4/7 DME Specific Peptides for DHX36 (Q9H2U1) (see all 7)
     TNIAETS  AETSITI  RSDLKVI  VILMSAT 

    DHX36 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DHX36 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001107869.1  NP_065916.2  

    ENSEMBL proteins: 
     ENSP00000417078   ENSP00000309296   ENSP00000330113   ENSP00000418756   ENSP00000419862  
     ENSP00000419761   ENSP00000444247  
    Reactome Protein details: Q9H2U1
    Human Recombinant Protein Products for DHX36: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DHX36
    OriGene Protein Over-expression Lysate for DHX36
    OriGene MassSpec for DHX36 
    OriGene Custom Protein Services for DHX36
    GenScript Custom Purified and Recombinant Proteins Services for DHX36
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DHX36 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    DHX36 for ontologies           About GeneDecksing



    DHX36 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DHX36
    GenScript Custom Superior Antibodies Services for DHX36
    Novus Biologicals DHX36 Antibodies
    Abcam antibodies for DHX36
    Cloud-Clone Corp. Antibodies for DHX36 
    ThermoFisher Antibodies for DHX36
    LSBio Antibodies in human, mouse, rat for DHX36 

    Assay Products for DHX36: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DHX36
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DHX36
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DHX36 
    Cloud-Clone Corp. CLIAs for DHX36


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DHX: DEAH-boxes

    5/7 InterPro protein domains (see all 7):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR002464 DNA/RNA_helicase_DEAH_CS
     IPR007502 Helicase-assoc_dom
     IPR011709 DUF1605
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9H2U1

    ProtoNet protein and cluster: Q9H2U1

    2 Blocks protein domains:
    IPB002464 ATP-dependent helicase
    IPB007502 Helicase-associated region


    UniProtKB/Swiss-Prot: DHX36_HUMAN, Q9H2U1
    Similarity: Belongs to the DEAD box helicase family. DEAH subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    DHX36 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DHX36_HUMAN, Q9H2U1
    Function: Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE
    sequence element. May function in sex development and spermatogenesis
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003725double-stranded RNA binding IEA--
    GO:0004386helicase activity ----
    GO:0005515protein binding IPI17932509
    GO:0005524ATP binding IEA--
         
    DHX36 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DHX36:
     Increased G1 DNA content  Increased cell size 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dhx36):
     cellular  hematopoietic system  immune system  integument  liver/biliary system 
     mortality/aging  renal/urinary system 

    DHX36 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dhx36tm1.1Pmt for DHX36

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DHX36 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DHX36

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DHX36 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DHX36 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DHX36
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate DHX36:
    hsa-miR-3671 hsa-miR-607 hsa-miR-383 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-3919 hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidDHX36 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DHX36
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DHX36

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DHX36
    Sirion Biotech Customized adenovirus for overexpression of DHX36

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for DHX36 (see all 11)
    OriGene ORF clones in mouse, rat for DHX36
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DHX36 (NM_020865)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHX36
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX36
    Sirion Biotech Customized lentivirus for stable overexpression of DHX36 
                         Customized lentivirus expression plasmids for stable overexpression of DHX36 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DHX36
    Search LifeMap BioReagents cell lines for DHX36
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX36


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DHX36 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Innate Immune System0.50
    2Deadenylation-dependent mRNA decay
    RNA degradation0.49
    3Cytosolic DNA-sensing pathway
    Cytosolic sensors of pathogen-associated DNA 0.36
    4DEx/H-box helicases activate type I IFN and inflammatory cytokines production
    DEx/H-box helicases activate type I IFN and inflammatory cytokines production

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for DHX36
        DEx/H-box helicases activate type I IFN and inflammatory cytokines production
    Cytosolic sensors of pathogen-associated DNA
    Immune System
    Innate Immune System


    1         Kegg Pathway  (Kegg details for DHX36):
        RNA degradation


    DHX36 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DHX36

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/175 Interacting proteins for DHX36 (Q9H2U12, 3 ENSP000004170784) via UniProtKB, MINT, STRING, and/or I2D (see all 175)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PHBP352322, 3MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 
    RPS9P467812, 3MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 
    AGO1Q9UL182, ENSP000003623004MINT-6167681 MINT-6488590 MINT-6488791 STRING: ENSP00000362300
    UBCP0CG482, ENSP000003448184MINT-6489355 MINT-6488791 STRING: ENSP00000344818
    AGO2Q9UKV82, ENSP000002205924MINT-6167681 MINT-6489355 STRING: ENSP00000220592
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009615response to virus IEA--
    GO:0032481positive regulation of type I interferon production TAS--
    GO:0043330response to exogenous dsRNA IEA--
    GO:0045087innate immune response TAS--

    DHX36 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DHX36

    Search CenterWatch for drugs/clinical trials and news about DHX36

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DHX36 gene (2 alternative transcripts): 
    NM_001114397.1  NM_020865.2  

    Unigene Cluster for DHX36:

    DEAH (Asp-Glu-Ala-His) box polypeptide 36
    Hs.446270  [show with all ESTs]
    Unigene Representative Sequence: NM_020865
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000496811(uc010hvq.3 uc003ezy.4 uc003ezz.4) ENST00000308361
    ENST00000495598 ENST00000329463 ENST00000477549 ENST00000479934 ENST00000481941
    ENST00000460695 ENST00000469977 ENST00000481332 ENST00000460875 ENST00000462464
    ENST00000491011 ENST00000544526
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DHX36
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate DHX36:
    hsa-miR-3671 hsa-miR-607 hsa-miR-383 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-3919 hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidDHX36 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DHX36
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DHX36
    Clone
    Products:
         
    OriGene clones in human, mouse for DHX36 (see all 11)
    OriGene ORF clones in mouse, rat for DHX36
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DHX36 (NM_020865)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHX36
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX36
    Sirion Biotech Customized lentivirus for stable overexpression of DHX36 
                         Customized lentivirus expression plasmids for stable overexpression of DHX36 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DHX36
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DHX36
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DHX36
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHX36

    Additional mRNA sequence: 

    AB040921.1 AF217190.1 AJ577133.1 AJ577134.1 AK096808.1 AK303720.1 AK314435.1 BC036035.1 

    11 DOTS entries:

    DT.446538  DT.100784723  DT.91890324  DT.100723681  DT.120886479  DT.100659478  DT.95270999  DT.95271000 
    DT.102824538  DT.95270996  DT.100734876 

    24/255 AceView cDNA sequences (see all 255):

    AW051585 N91377 CD366211 Z43572 BU165221 W23444 BQ416908 AJ577134 
    AA505255 T34062 AI937206 BQ722339 BM475651 T52311 AW576359 F13265 
    AI806849 F01645 BF726166 AI952068 N64533 AA411781 BU151002 BM761719 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DHX36 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCACTCTTT
    DHX36 Expression
    About this image


    See DHX36 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DHX36

    SOURCE GeneReport for Unigene cluster: Hs.446270

    UniProtKB/Swiss-Prot: DHX36_HUMAN, Q9H2U1
    Tissue specificity: Highly expressed in testis

        SABiosciences Custom PCR Arrays for DHX36
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for DHX36
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DHX36
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DHX36
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHX36
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX36

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DHX36 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dhx361 , 5 DEAH (Asp-Glu-Ala-His) box polypeptide 361, 5 88.91(n)1
    92.61(a)1
      3 (29.97 cM)5
    721621  NM_028136.21  NP_082412.21 
     624700395 
    chicken
    (Gallus gallus)
    Aves DHX361 DEAH (Asp-Glu-Ala-His) box polypeptide 36 75.22(n)
    81.01(a)
      425032  XM_422834.3  XP_422834.3 
    lizard
    (Anolis carolinensis)
    Reptilia DHX366
    Uncharacterized protein
    73(a)
    1 ↔ 1
    3(16658575-16697818)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.166102 Xenopus laevis transcribed sequence with moderate similarity more 78.15(n)    BJ074783.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-119o24.11 si:dkey-119o24.1 64.08(n)
    67.53(a)
      569072  NM_001128544.1  NP_001122016.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG93231 CG9323 46.95(n)
    40.31(a)
      35339  NM_136212.1  NP_610056.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G486501 DEA(D/H)-box RNA helicase family protein 53.16(n)
    45.07(a)
      841287  NM_103761.5  NP_175298.2 


    ENSEMBL Gene Tree for DHX36 (if available)
    TreeFam Gene Tree for DHX36 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DHX36 gene
    DHX292  DHX302  TDRD92  YTHDC22  DHX572  DHX92  
    11 SIMAP similar genes for DHX36 using alignment to 5 protein entries:     DHX36_HUMAN (see all proteins):
    DHX29    YTHDC2    DHX9    DHX57    DHX30    DHX40
    DHX33    TDRD9    DKFZp762F2011    HIG-1    DHX35

    DHX36 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1011 SNPs in DHX36 are shown (see all 1011)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1162534211,2
    F--153993141(+) CATGTT/CCAGTA 2 -- int11Minor allele frequency- C:0.01NA 120
    rs729966161,2
    C,F--153993168(+) TTTTTC/TCCCCA 2 -- int11Minor allele frequency- T:0.50WA 2
    rs1923910951,2
    --153993222(+) GCATGG/TATATG 2 -- int10--------
    rs1995754641,2
    C--153993261(+) GAAAAA/GGGAGA 2 -- int10--------
    rs2016877781,2
    C--153993262(-) CTCTCC/TTTTTT 2 -- int10--------
    rs680024351,2
    C--153993263(+) AAAGG-/AAGAGA 2 -- int10--------
    rs1828777021,2
    --153993352(+) TATTAG/TGAGGC 2 -- int10--------
    rs1422159911,2
    --153993467(+) TTTAAC/GATTGT 2 -- ut310--------
    rs1443998581,2
    --153993489(+) AATACC/TGGACT 2 -- ut310--------
    rs729966191,2
    C,F--153993520(+) ACTTCC/TGATAG 2 -- ut311Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for DHX36 (153990335 - 154042286 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DHX36:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv4073CNV Insertion18451855


    Human Gene Mutation Database (HGMD): DHX36
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DHX36
    DNA2.0 Custom Variant and Variant Library Synthesis for DHX36

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DHX36 for disorders           About MalaCards
    OMIM gene information: 612767    OMIM disorders: --


    DHX36 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DHX36
    Human Genome Epidemiology (HuGE) Navigator: DHX36 (1 document)

    Export disorders for DHX36 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DHX36 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with DHX36)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of human DDX36 and mouse Ddx36 genes, new members of the DEAD/H box superfamily. (PubMed id 12198572)1, 2, 9 Fu J.-J.... Lu G.-X. (2002)
    2. Proteomic and functional analysis of Argonaute-containing mRNA- protein complexes in human cells. (PubMed id 17932509)1, 2 Hoeck J.... Meister G. (2007)
    3. Facilitation of mRNA deadenylation and decay by the exosome-bound, DExH protein RHAU. (PubMed id 14731398)1, 2 Tran H.... Nagamine Y. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
    6. Expression research for human DDX36 and mouse Ddx36 gene in the adult testis. (PubMed id 12812084)1, 9 Fu J.J....Lu G.X. (2003)
    7. The DEXH protein product of the DHX36 gene is the major source of tetramolecular quadruplex G4-DNA resolving activity in HeLa cell lysates. (PubMed id 16150737)1, 9 Vaughn J.P....Akman S.A. (2005)
    8. Cleavage and polyadenylation specificity factor 1 (CPS F1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6. (PubMed id 23151878)1 Evsyukova I....Garcia-Blanco M.A. (2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 170506 HGNC: 14410 AceView: DHX36 Ensembl:ENSG00000174953 euGenes: HUgn170506
    ECgene: DHX36 Kegg: 170506 H-InvDB: DHX36

    (According to HUGE)
    About This Section
    HUGE: KIAA1488

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DHX36 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DHX36 gene:
    Search GeneIP for patents involving DHX36

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DHX36  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for DHX36  
     OriGene MassSpec something-or-other for DHX36   OriGene clones in human, mouse for DHX36  
     OriGene qSTAR qPCR primer pairs in human, mouse for DHX36   OriGene Purified Protein for DHX36  
     OriGene ORF clones in mouse, rat for DHX36   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DHX36   OriGene Custom Protein Services for DHX36  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DHX36
     QIAGEN SeqTarget long-range PCR primers for resequencing DHX36
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHX36
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DHX36
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHX36
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DHX36
     GenScript Custom Purified and Recombinant Proteins Services for DHX36 GenScript cDNA clones with any tag delivered in your preferred vector for DHX36
     GenScript Custom Assay Services for DHX36 GenScript Custom Superior Antibodies Services for DHX36
     GenScript Custom overexpressing Cell Line Services for DHX36 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in DHX36 promoter
     Search Chromatin IP Primers for DHX36
     RT2 qPCR Primer Assay in human, mouse, rat DHX36
     Search GNC Networks for DHX36
     SABiosciences Custom PCR Arrays for DHX36
     Search Tocris compounds for DHX36
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     DHX36 antibodies
     Antibodies for DHX36
     See all of Abcam's Antibodies, Kits and Proteins for DHX36
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for DHX36
     Antibodies for DHX36
     ELISAs for DHX36
     CLIAs for DHX36
     Search LifeMap BioReagents cell lines for DHX36
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX36
     SwitchGear 3'UTR luciferase reporter plasmids for DHX36
     SwitchGear Promoter luciferase reporter plasmids for DHX36
     ThermoFisher Antibodies for DHX36
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX36
     inGenious Targeting Laboratory - Custom generated mouse model solutions for DHX36
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DHX36
    Customized:
     lentivirus for stable overexpression of DHX36
     lentivirus expression plasmids for stable overexpression of DHX36
     adenovirus for overexpression of DHX36
     LSBio Antibodies in human, mouse, rat for DHX36
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DHX36 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4