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DHX36 Gene

protein-coding   GIFtS: 61
GCID: GC03M153990

DEAH (Asp-Glu-Ala-His) Box Polypeptide 36

(Previous name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 36)
(Previous symbol: DDX36)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEAH (Asp-Glu-Ala-His) Box Polypeptide 361 2     RNA Helicase Associated With AU-Rich Element ARE2 3
DDX361 2 3     G4R12 5
RHAU2 3 5     KIAA14883 5
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 361 2     G4 Resolvase-12
MLEL12 3     Probable ATP-Dependent RNA Helicase DHX362
DEAH Box Protein 362 3     EC 3.6.4.133
MLE-Like Protein 12 3     EC 3.6.18

External Ids:    HGNC: 144101   Entrez Gene: 1705062   Ensembl: ENSG000001749537   OMIM: 6127675   UniProtKB: Q9H2U13   

Export aliases for DHX36 gene to outside databases

Previous GC identifers: GC03M155275 GC03M155314 GC03M155476 GC03M151389


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DHX36 Gene:
This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino
acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the
deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to
resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously
in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different
isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for DHX36 Gene:
DHX36 (DEAH (Asp-Glu-Ala-His) box polypeptide 36) is a protein-coding gene. GO annotations related to this gene include double-stranded RNA binding and ATP-dependent helicase activity. An important paralog of this gene is DHX29.

UniProtKB/Swiss-Prot: DHX36_HUMAN, Q9H2U1
Function: Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE
sequence element. May function in sex development and spermatogenesis

Gene Wiki entry for DHX36 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  NT_187533.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the DHX36 gene promoter:
         AML1a   Meis-1b   HNF-1A   RORalpha1   Nkx6-1   HNF-1   Meis-1a   LyF-1   Meis-1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDHX36 promoter sequence
   Search Chromatin IP Primers for DHX36

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DHX36


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.2   Ensembl cytogenetic band:  3q25.2   HGNC cytogenetic band: 3q25.2

DHX36 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHX36 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M153990:  view genomic region     (about GC identifiers)

Start:
153,990,335 bp from pter      End:
154,042,286 bp from pter
Size:
51,952 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DHX36_HUMAN, Q9H2U1 (See protein sequence)
Recommended Name: Probable ATP-dependent RNA helicase DHX36  
Size: 1008 amino acids; 114760 Da
Subunit: Interacts with AGO1, AGO2, PARN, EXOSC3 and EXOSC10
Secondary accessions: B2RB00 Q70JU3 Q8IYE5 Q9P240
Alternative splicing: 3 isoforms:  Q9H2U1-1   Q9H2U1-2   Q9H2U1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DHX36: NX_Q9H2U1

Explore proteomics data for DHX36 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DHX36 (Q9H2U1) (see all 7)
     TNIAETS  AETSITI  RSDLKVI  VILMSAT 


    See DHX36 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001107869.1  NP_065916.2  

    ENSEMBL proteins: 
     ENSP00000417078   ENSP00000309296   ENSP00000330113   ENSP00000418756   ENSP00000419862  
     ENSP00000419761   ENSP00000444247  
    Reactome Protein details: Q9H2U1

    DHX36 Human Recombinant Protein Products:

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    antibodies-online peptides for DHX36

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DHX: DEAH-boxes

    Selected InterPro protein domains (see all 7):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR002464 DNA/RNA_helicase_DEAH_CS
     IPR007502 Helicase-assoc_dom
     IPR011709 DUF1605
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9H2U1

    ProtoNet protein and cluster: Q9H2U1

    2 Blocks protein domains:
    IPB002464 ATP-dependent helicase
    IPB007502 Helicase-associated region


    UniProtKB/Swiss-Prot: DHX36_HUMAN, Q9H2U1
    Similarity: Belongs to the DEAD box helicase family. DEAH subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Find genes that share domains with DHX36           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DHX36_HUMAN, Q9H2U1
    Function: Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE
    sequence element. May function in sex development and spermatogenesis
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003725double-stranded RNA binding IDA--
    GO:0004386helicase activity ----
    GO:0005515protein binding IPI17932509
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with DHX36           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DHX36:
     Increased G1 DNA content  Increased cell size 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dhx36):
     cellular  hematopoietic system  immune system  integument  liver/biliary system 
     mortality/aging  renal/urinary system 

    Find genes that share phenotypes with DHX36           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dhx36tm1.1Pmt for DHX36

       genOway: Develop your customized and physiologically relevant rodent model for DHX36

    miRNA
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    miRTarBase miRNAs that target DHX36:
    hsa-mir-16-5p (MIRT031417), hsa-mir-30a-5p (MIRT028475)

    Block miRNA regulation of human, mouse, rat DHX36 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate DHX36:
    hsa-miR-3671 hsa-miR-607 hsa-miR-383 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-3919 hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidDHX36 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DHX36

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    Browse Sino Biological Human cDNA Clones
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    Addgene plasmids for DHX36 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DHX36_HUMAN, Q9H2U1: Nucleus. Cytoplasm. Note=Isoform 1 preferentially localized to the nucleus and isoform 2
    localized to the cytoplasm. However, partitioning of cellular localization between the nucleus and cytoplasm is
    not exclusive, as isoform 1 was also detected in the cytoplasm. Both isoforms were excluded from nucleoli
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with DHX36           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DHX36 About    
    See pathways by source

    SuperPathContained pathways About
    1Toll Like Receptor 7/8 (TLR7/8) Cascade
    Toll Like Receptor 9 (TLR9) Cascade0.93
    MyD88 dependent cascade initiated on endosome0.69
    Toll Like Receptor 7/8 (TLR7/8) Cascade0.69
    TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling0.00
    2RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    TRAF6 mediated IRF7 activation0.40
    3Cytosolic sensors of pathogen-associated DNA
    Cytosolic sensors of pathogen-associated DNA0.38
    DEx/H-box helicases activate type I IFN and inflammatory cytokines production0.00
    4Deadenylation-dependent mRNA decay
    RNA degradation0.48


    Find genes that share SuperPaths with DHX36           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Reactome Pathways for DHX36
        DEx/H-box helicases activate type I IFN and inflammatory cytokines production
    TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
    TRAF6 mediated IRF7 activation


    1 Kegg Pathway  (Kegg details for DHX36):
        RNA degradation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DHX36
    Interactions:

        Search GeneGlobe Interaction Network for DHX36

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DHX36 (Q9H2U12, 3 ENSP000004170784) via UniProtKB, MINT, STRING, and/or I2D (see all 211)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PHBP352322, 3MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 
    RPS9P467812, 3MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 
    AGO1Q9UL182, ENSP000003623004MINT-6167681 MINT-6488590 MINT-6488791 STRING: ENSP00000362300
    SF3B1O755332, ENSP000003353214MINT-6488590 MINT-6489355 MINT-6488791 STRING: ENSP00000335321
    UBCP0CG482, ENSP000003448184MINT-6489355 MINT-6488791 STRING: ENSP00000344818
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    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009615response to virus IEA--
    GO:0032481positive regulation of type I interferon production TAS--
    GO:0043330response to exogenous dsRNA IEA--
    GO:0045087innate immune response TAS--

    Find genes that share ontologies with DHX36           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DHX36



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DHX36 gene (2 alternative transcripts): 
    NM_001114397.1  NM_020865.2  

    Unigene Cluster for DHX36:

    DEAH (Asp-Glu-Ala-His) box polypeptide 36
    Hs.446270  [show with all ESTs]
    Unigene Representative Sequence: NM_020865
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000496811(uc010hvq.3 uc003ezy.4 uc003ezz.4) ENST00000308361
    ENST00000495598 ENST00000329463 ENST00000477549 ENST00000479934 ENST00000481941
    ENST00000460695 ENST00000469977 ENST00000481332 ENST00000460875 ENST00000462464
    ENST00000491011 ENST00000544526
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate DHX36:
    hsa-miR-3671 hsa-miR-607 hsa-miR-383 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-3919 hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidDHX36 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat DHX36

    Additional mRNA sequence: 

    AB040921.1 AF217190.1 AJ577133.1 AJ577134.1 AK096808.1 AK303720.1 AK314435.1 BC036035.1 

    11 DOTS entries:

    DT.446538  DT.100784723  DT.91890324  DT.100723681  DT.120886479  DT.100659478  DT.95270999  DT.95271000 
    DT.102824538  DT.95270996  DT.100734876 

    Selected AceView cDNA sequences (see all 255):

    T52311 CA944953 AW769879 T34062 AI610826 AI867922 BX645007 CD244340 
    AA411781 W35259 AJ577133 AA484948 BX509253 BM843076 F10865 AW051585 
    BQ416909 CA455105 CD366211 BQ439375 AJ577134 AI204678 AI183404 BQ416908 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DHX36 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCACTCTTT
    DHX36 Expression
    About this image

    DHX36 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DHX36 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.446270

    UniProtKB/Swiss-Prot: DHX36_HUMAN, Q9H2U1
    Tissue specificity: Highly expressed in testis

        Custom PCR Arrays for DHX36
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX36

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DHX36 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dhx361 , 5 DEAH (Asp-Glu-Ala-His) box polypeptide 361, 5 88.28(n)1
    91.51(a)1
      3 (29.97 cM)5
    721621  NM_028136.21  NP_082412.21 
     624700395 
    chicken
    (Gallus gallus)
    Aves DHX361 DEAH (Asp-Glu-Ala-His) box polypeptide 36 76.04(n)
    82.14(a)
      425032  XM_422834.4  XP_422834.3 
    lizard
    (Anolis carolinensis)
    Reptilia DHX366
    DEAH (Asp-Glu-Ala-His) box polypeptide 36
    73(a)
    1 ↔ 1
    3(16658575-16697818)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.166102 Xenopus laevis transcribed sequence with moderate similarity more 78.15(n)    BJ074783.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-119o24.11 si:dkey-119o24.1 65.25(n)
    69.32(a)
      569072  NM_001128544.1  NP_001122016.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG93231 CG9323 47.61(n)
    41.14(a)
      35339  NM_001273710.1  NP_001260639.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes --
    Putative helicase with limited sequence similarity...
    19(a)
    1 → many
    XII(958428-962735) YLR419W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G359201 AT2G35920 53.27(n)
    47.36(a)
      818165  NM_179924.1  NP_850255.1 


    ENSEMBL Gene Tree for DHX36 (if available)
    TreeFam Gene Tree for DHX36 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DHX36 gene
    DHX292  DHX302  TDRD92  YTHDC22  DHX572  DHX92  
    11 SIMAP similar genes for DHX36 using alignment to 5 protein entries:     DHX36_HUMAN (see all proteins):
    DHX29    YTHDC2    DHX9    DHX57    DHX30    DHX40
    DHX33    TDRD9    DKFZp762F2011    HIG-1    DHX35

    Find genes that share paralogs with DHX36           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DHX36 (see all 1011)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1162534211,2
    F--153993141(+) CATGTT/CCAGTA 2 -- int11Minor allele frequency- C:0.01NA 120
    rs729966161,2
    C,F--153993168(+) TTTTTC/TCCCCA 2 -- int11Minor allele frequency- T:0.50WA 2
    rs1923910951,2
    --153993222(+) GCATGG/TATATG 2 -- int10--------
    rs1995754641,2
    C--153993261(+) GAAAAA/GGGAGA 2 -- int10--------
    rs2016877781,2
    C--153993262(-) CTCTCC/TTTTTT 2 -- int10--------
    rs680024351,2
    C--153993263(+) AAAGG-/AAGAGA 2 -- int10--------
    rs1828777021,2
    --153993352(+) TATTAG/TGAGGC 2 -- int10--------
    rs1422159911,2
    --153993467(+) TTTAAC/GATTGT 2 -- ut310--------
    rs1443998581,2
    --153993489(+) AATACC/TGGACT 2 -- ut310--------
    rs729966191,2
    C,F--153993520(+) ACTTCC/TGATAG 2 -- ut311Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for DHX36 (153990335 - 154042286 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DHX36:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4073CNV Insertion18451855

    Human Gene Mutation Database (HGMD): DHX36
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DHX36
    DNA2.0 Custom Variant and Variant Library Synthesis for DHX36

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612767    OMIM disorders: --


    Find genes that share disorders with DHX36           About GenesLikeMe

    Genetic Association Database (GAD): DHX36
    Human Genome Epidemiology (HuGE) Navigator: DHX36 (1 document)

    Export disorders for DHX36 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DHX36 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with DHX36)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of human DDX36 and mouse Ddx36 genes, new members of the DEAD/H box superfamily. (PubMed id 12198572)1, 2, 9 Fu J.-J.... Lu G.-X. (Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 2002)
    2. Proteomic and functional analysis of Argonaute-containing mRNA- protein complexes in human cells. (PubMed id 17932509)1, 2 Hoeck J.... Meister G. (EMBO Rep. 2007)
    3. Facilitation of mRNA deadenylation and decay by the exosome-bound, DExH protein RHAU. (PubMed id 14731398)1, 2 Tran H.... Nagamine Y. (Mol. Cell 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    6. Expression research for human DDX36 and mouse Ddx36 gene in the adult testis. (PubMed id 12812084)1, 9 Fu J.J....Lu G.X. (Yi Chuan Xue Bao 2003)
    7. The DEXH protein product of the DHX36 gene is the major source of tetramolecular quadruplex G4-DNA resolving activity in HeLa cell lysates. (PubMed id 16150737)1, 9 Vaughn J.P....Akman S.A. (J. Biol. Chem. 2005)
    8. Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6. (PubMed id 23151878)1 Evsyukova I....Garcia-Blanco M.A. (RNA 2013)
    9. Binding of G-quadruplexes to the N-terminal recognition domain of the RNA helicase associated with AU-rich element (RHAU). (PubMed id 24151078)1 Meier M....McKenna S.A. (J. Biol. Chem. 2013)
    10. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 170506 HGNC: 14410 AceView: DHX36 Ensembl:ENSG00000174953 euGenes: HUgn170506
    ECgene: DHX36 Kegg: 170506 H-InvDB: DHX36

    (According to HUGE)
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    HUGE: KIAA1488

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DHX36 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DHX36 gene:
    Search GeneIP for patents involving DHX36

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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