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Aliases for DHX35 Gene

Aliases for DHX35 Gene

  • DEAH-Box Helicase 35 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 35 2 3
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 35 2 3
  • C20orf15 3 4
  • DDX35 3 4
  • Probable ATP-Dependent RNA Helicase DHX35 3
  • DEAH-Box Protein 35 3
  • DEAH Box Protein 35 4
  • EC 4
  • KAIA0875 3
  • EC 3.6.1 58

External Ids for DHX35 Gene

Previous HGNC Symbols for DHX35 Gene

  • C20orf15
  • DDX35

Previous GeneCards Identifiers for DHX35 Gene

  • GC20P038229
  • GC20P038276
  • GC20P037024
  • GC20P037590
  • GC20P034328

Summaries for DHX35 Gene

Entrez Gene Summary for DHX35 Gene

  • DEAD box proteins characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The function of this gene product which is a member of this family, has not been determined. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for DHX35 Gene

DHX35 (DEAH-Box Helicase 35) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DHX38.

UniProtKB/Swiss-Prot for DHX35 Gene

  • May be involved in pre-mRNA splicing.

Additional gene information for DHX35 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX35 Gene

Genomics for DHX35 Gene

Regulatory Elements for DHX35 Gene

Enhancers for DHX35 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H038985 1.4 Ensembl ENCODE dbSUPER 33.3 +23.5 23465 1.5 HDAC1 ELF3 RARA ZNF366 SCRT2 RCOR1 RUNX3 HMG20B ZEB2 NR2F2 DHX35 NPM1P19 PIR38411
GH20H038139 2 FANTOM5 Ensembl ENCODE dbSUPER 22.6 -806.3 -806309 33.6 MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF143 SP3 MCM3 NFYC RALGAPB ACTR5 RN7SKP173 TTI1 SNHG17 DHX35 ENSG00000224635 SNORA71A CTNNBL1 RPN2
GH20H038960 1.4 ENCODE dbSUPER 29.5 -0.2 -168 2.5 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 ZNF766 ZNF143 DHX35 FAM83D RALGAPB SNHG17 SNORA71C RN7SKP173 ACTR5 SNORA60 TTI1 ENSG00000261431
GH20H039049 1.6 FANTOM5 Ensembl ENCODE 22.7 +87.8 87804 1.4 HDGF ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 ZNF143 DEK DHX35 ACTR5 RALGAPB SLC32A1 PPP1R16B PIR38411 NPM1P19
GH20H038925 1.4 ENCODE dbSUPER 25.9 -34.2 -34225 4.8 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5 ZNF302 ZNF207 ACTR5 DHX35 SNORA60 FAM83D SNHG17 RALGAPB SNHG11 SNORA71A GC20M038952
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DHX35 on UCSC Golden Path with GeneCards custom track

Promoters for DHX35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000137065 201 1801 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 ZNF766 ZNF143

Genomic Locations for DHX35 Gene

Genomic Locations for DHX35 Gene
77,425 bases
Plus strand

Genomic View for DHX35 Gene

Genes around DHX35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX35 Gene

Proteins for DHX35 Gene

  • Protein details for DHX35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ATP-dependent RNA helicase DHX35
    Protein Accession:
    Secondary Accessions:
    • A2RTX3
    • B4E0J0
    • F5GXM6
    • Q5THR0
    • Q9H4H7
    • Q9H6T6

    Protein attributes for DHX35 Gene

    703 amino acids
    Molecular mass:
    78910 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.
    • Sequence=BAB15166.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DHX35 Gene


neXtProt entry for DHX35 Gene

Selected DME Specific Peptides for DHX35 Gene


Post-translational modifications for DHX35 Gene

  • Ubiquitination at isoforms=2326, posLast=413413, posLast=435435, and isoforms=2591
  • Modification sites at PhosphoSitePlus

Domains & Families for DHX35 Gene

Gene Families for DHX35 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DHX35 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DEAD box helicase family. DEAH subfamily.
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX35: view

Function for DHX35 Gene

Molecular function for DHX35 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
May be involved in pre-mRNA splicing.

Enzyme Numbers (IUBMB) for DHX35 Gene

Phenotypes From GWAS Catalog for DHX35 Gene

Gene Ontology (GO) - Molecular Function for DHX35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DHX35: view
genes like me logo Genes that share phenotypes with DHX35: view

Animal Models for DHX35 Gene

MGI Knock Outs for DHX35:

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DHX35 Gene

Localization for DHX35 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHX35 gene
Compartment Confidence
nucleus 5
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nuclear bodies (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DHX35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005681 spliceosomal complex IEA --
GO:0005737 cytoplasm IBA --
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with DHX35: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DHX35 Gene

Pathways & Interactions for DHX35 Gene

SuperPathways for DHX35 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHX35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0006396 RNA processing IBA --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with DHX35: view

No data available for Pathways by source and SIGNOR curated interactions for DHX35 Gene

Drugs & Compounds for DHX35 Gene

(3) Drugs for DHX35 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Nutra Agonist 0

(1) Additional Compounds for DHX35 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DHX35: view

Transcripts for DHX35 Gene

Unigene Clusters for DHX35 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 35:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX35 Gene

No ASD Table

Relevant External Links for DHX35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHX35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHX35 Gene

Protein differential expression in normal tissues from HIPED for DHX35 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (34.8) and Placenta (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DHX35 Gene

Protein tissue co-expression partners for DHX35 Gene

NURSA nuclear receptor signaling pathways regulating expression of DHX35 Gene:


SOURCE GeneReport for Unigene cluster for DHX35 Gene:


Evidence on tissue expression from TISSUES for DHX35 Gene

  • Nervous system(4.6)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with DHX35: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHX35 Gene

Orthologs for DHX35 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX35 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DHX35 33 34
  • 99 (n)
(Canis familiaris)
Mammalia DHX35 33 34
  • 91.3 (n)
(Monodelphis domestica)
Mammalia DHX35 34
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia DHX35 34
  • 91 (a)
(Bos Taurus)
Mammalia DHX35 33 34
  • 90.31 (n)
(Mus musculus)
Mammalia Dhx35 33 16 34
  • 88.35 (n)
(Rattus norvegicus)
Mammalia Dhx35 33
  • 88.35 (n)
(Gallus gallus)
Aves DHX35 33 34
  • 79.77 (n)
(Anolis carolinensis)
Reptilia DHX35 34
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx35 33
  • 73.9 (n)
(Danio rerio)
Actinopterygii DHX35 34
  • 77 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3225 33 34
  • 54.59 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010872 33
  • 54.34 (n)
(Caenorhabditis elegans)
Secernentea Y67D2.6 33 34
  • 56.68 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G18465 33
  • 54.98 (n)
(Oryza sativa)
Liliopsida Os01g0212100 33
  • 54.17 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06735 33
  • 55.17 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC20H4.09 33
  • 49.76 (n)
Species where no ortholog for DHX35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHX35 Gene

Gene Tree for DHX35 (if available)
Gene Tree for DHX35 (if available)

Paralogs for DHX35 Gene

Paralogs for DHX35 Gene

(11) SIMAP similar genes for DHX35 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DHX35: view

Variants for DHX35 Gene

Sequence variations from dbSNP and Humsavar for DHX35 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000097166 -- 39,008,064(+) GCTAC(C/T)AGTCC intron-variant
rs1000182806 -- 38,999,133(+) CAGTA(C/T)CACAT intron-variant
rs1000265905 -- 38,967,010(+) ATGAC(A/G)GTGCC intron-variant
rs1000267686 -- 39,013,480(+) TATCC(C/T)AAATC intron-variant
rs1000279986 -- 38,969,450(+) TTAGA(A/G)TGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHX35 Gene

Variant ID Type Subtype PubMed ID
nsv979433 CNV duplication 23825009
nsv833973 CNV loss 17160897
esv3645799 CNV loss 21293372
esv3645798 CNV loss 21293372
esv3645797 CNV gain 21293372
esv3645796 CNV loss 21293372
esv3645795 CNV gain 21293372
esv3645794 CNV loss 21293372
esv3645793 CNV gain 21293372

Variation tolerance for DHX35 Gene

Residual Variation Intolerance Score: 15.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.71; 86.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHX35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX35 Gene

Disorders for DHX35 Gene

Relevant External Links for DHX35

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DHX35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX35 Gene

Publications for DHX35 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica MS … Moore MJ (RNA (New York, N.Y.) 2002) 3 4 60
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for DHX35 Gene

Sources for DHX35 Gene

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