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DHX35 Gene

protein-coding   GIFtS: 50
GCID: GC20P037590

DEAH (Asp-Glu-Ala-His) Box Polypeptide 35

(Previous name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 35)
(Previous symbols: C20orf15, DDX35)
  Search for DHX35
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEAH (Asp-Glu-Ala-His) Box Polypeptide 351 2     KAIA08752
C20orf151 2 3     DEAH-Box Protein 352
DDX351 2 3     Probable ATP-Dependent RNA Helicase DHX352
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 351 2     EC 3.6.4.133
DEAH Box Protein 352 3     EC 3.6.18

External Ids:    HGNC: 158611   Entrez Gene: 606252   Ensembl: ENSG000001014527   UniProtKB: Q9H5Z13   

Export aliases for DHX35 gene to outside databases

Previous GC identifers: GC20P038229 GC20P038276 GC20P037024 GC20P034328


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DHX35 Gene:
DEAD box proteins characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They
are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their
distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis,
spermatogenesis, and cellular growth and division. The function of this gene product which is a member of this
family, has not been determined. Alternatively spliced transcript variants have been found for this gene.
(provided by RefSeq, Jun 2010)

GeneCards Summary for DHX35 Gene:
DHX35 (DEAH (Asp-Glu-Ala-His) box polypeptide 35) is a protein-coding gene. GO annotations related to this gene include ATP-dependent helicase activity and nucleic acid binding. An important paralog of this gene is DHX33.

UniProtKB/Swiss-Prot: DHX35_HUMAN, Q9H5Z1
Function: May be involved in pre-mRNA splicing




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DHX35 gene promoter:
         GR   STAT5B   USF1   GATA-3   C/EBPalpha   USF-1   FOXJ2 (long isoform)   Cart-1   GR-alpha   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDHX35 promoter sequence
   Search Chromatin IP Primers for DHX35

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DHX35


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.22-q12   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q11.22-q12

DHX35 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHX35 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P037590:  view genomic region     (about GC identifiers)

Start:
37,590,942 bp from pter      End:
37,668,366 bp from pter
Size:
77,425 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DHX35_HUMAN, Q9H5Z1 (See protein sequence)
Recommended Name: Probable ATP-dependent RNA helicase DHX35  
Size: 703 amino acids; 78910 Da
Subunit: Identified in the spliceosome C complex
Sequence caution: Sequence=BAB15166.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A2RTX3 B4E0J0 F5GXM6 Q5THR0 Q9H4H7 Q9H6T6
Alternative splicing: 2 isoforms:  Q9H5Z1-1   Q9H5Z1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DHX35: NX_Q9H5Z1

Explore proteomics data for DHX35 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys9, Lys326, Lys413, Lys435, Lys591
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DHX35 (Q9H5Z1) (see all 6)
     FLTGQEE  AETSITI  CYRLYTE  LDEAHERT 


    See DHX35 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001177738.1  NP_068750.2  

    ENSEMBL proteins: 
     ENSP00000362422   ENSP00000252011   ENSP00000362420   ENSP00000432603   ENSP00000397997  

    DHX35 Human Recombinant Protein Products:

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    Novus Biologicals DHX35 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for DHX35 

    DHX35 Antibody Products:

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    Abcam antibodies for DHX35
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    Search ThermoFisher Antibodies for DHX35
    LSBio Antibodies in human, mouse, rat for DHX35

    DHX35 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for DHX35 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DHX: DEAH-boxes

    Selected InterPro protein domains (see all 6):
     IPR002464 DNA/RNA_helicase_DEAH_CS
     IPR007502 Helicase-assoc_dom
     IPR011709 DUF1605
     IPR027417 P-loop_NTPase
     IPR014001 Helicase_ATP-bd

    Graphical View of Domain Structure for InterPro Entry Q9H5Z1

    ProtoNet protein and cluster: Q9H5Z1

    2 Blocks protein domains:
    IPB002464 ATP-dependent helicase
    IPB007502 Helicase-associated region


    UniProtKB/Swiss-Prot: DHX35_HUMAN, Q9H5Z1
    Similarity: Belongs to the DEAD box helicase family. DEAH subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Find genes that share domains with DHX35           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DHX35_HUMAN, Q9H5Z1
    Function: May be involved in pre-mRNA splicing
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0004386helicase activity ----
    GO:0005524ATP binding IEA--
    GO:0008026ATP-dependent helicase activity IEA--
         
    Find genes that share ontologies with DHX35           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DHX35:
     Upregulation of Wnt/beta-caten 

         1 MGI phenotypic allele for Dhx35 (no phenotypes)

    Find genes that share phenotypes with DHX35           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DHX35
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DHX35
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DHX35

    miRNA
    Products:
        
    miRTarBase miRNAs that target DHX35:
    hsa-mir-16-5p (MIRT051221), hsa-mir-26b-5p (MIRT030327)

    Block miRNA regulation of human, mouse, rat DHX35 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DHX35 (see all 13):
    hsa-miR-142-5p hsa-miR-3163 hsa-miR-498 hsa-miR-4324 hsa-miR-610 hsa-miR-3688-3p hsa-miR-340 hsa-miR-544b
    SwitchGear 3'UTR luciferase reporter plasmidDHX35 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DHX35
    Predesigned siRNA for gene silencing in human, mouse, rat DHX35

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for DHX35
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DHX35 (NM_021931)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHX35
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX35

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for DHX35
    Browse ESI BIO Cell Lines and PureStem Progenitors for DHX35 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX35


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0071013catalytic step 2 spliceosome IDA11991638

    Find genes that share ontologies with DHX35           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DHX35
    Interactions:

        Search GeneGlobe Interaction Network for DHX35

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DHX35 (Q9H5Z13 ENSP000002520114) via UniProtKB, MINT, STRING, and/or I2D (see all 88)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLEKHF2Q9H8W43I2D: score=4 
    CDC5LENSP000003605324STRING: ENSP00000360532
    PRPF19ENSP000002275244STRING: ENSP00000227524
    BUD31ENSP000002229694STRING: ENSP00000222969
    CRNKL1ENSP000003665574STRING: ENSP00000366557
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome IC11991638

    Find genes that share ontologies with DHX35           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DHX35



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DHX35 gene (2 alternative transcripts): 
    NM_001190809.1  NM_021931.3  

    Unigene Cluster for DHX35:

    DEAH (Asp-Glu-Ala-His) box polypeptide 35
    Hs.444520  [show with all ESTs]
    Unigene Representative Sequence: NR_033905
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373325 ENST00000252011(uc010zwa.2 uc002xjh.3 uc010zwc.2 uc010zwb.2)
    ENST00000373323 ENST00000484417 ENST00000449559 ENST00000493450 ENST00000482619

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DHX35 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DHX35 (see all 13):
    hsa-miR-142-5p hsa-miR-3163 hsa-miR-498 hsa-miR-4324 hsa-miR-610 hsa-miR-3688-3p hsa-miR-340 hsa-miR-544b
    SwitchGear 3'UTR luciferase reporter plasmidDHX35 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DHX35
    Predesigned siRNA for gene silencing in human, mouse, rat DHX35
    Clone
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    OriGene clones in human, mouse for DHX35 (see all 10)
    OriGene ORF clones in mouse, rat for DHX35
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DHX35 (NM_021931)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHX35
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX35
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DHX35
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DHX35
      QuantiTect SYBR Green Assays in human, mouse, rat DHX35
      QuantiFast Probe-based Assays in human, mouse, rat DHX35

    Additional mRNA sequence: 

    AF086439.1 AK025541.1 AK026412.1 AK296506.1 AK296793.1 AK303396.1 AK307863.1 BC033453.1 
    BC059369.1 BC132669.1 BC143941.1 NR_033905.1 

    12 DOTS entries:

    DT.113731  DT.421794  DT.92424323  DT.100780520  DT.92424324  DT.97824596  DT.97842482  DT.100023339 
    DT.120825735  DT.120825749  DT.95262497  DT.120825746 

    Selected AceView cDNA sequences (see all 138):

    AI810135 AL521042 BU195036 AI078553 AA994891 AI521573 BQ011761 AI479647 
    CR617741 CA454127 AA234779 BQ011769 CA445767 AI084458 AI917285 BQ213833 
    AI522269 AI354824 AA370475 BE549921 BM554842 BM768801 AW069150 AW015983 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DHX35 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATAATAG
    DHX35 Expression
    About this image

    DHX35 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DHX35 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.444520
        Custom PCR Arrays for DHX35
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX35

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DHX35 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dhx351 , 5 DEAH (Asp-Glu-Ala-His) box polypeptide 351, 5 88.35(n)1
    94.99(a)1
      2 (78.74 cM)5
    717151  NM_145742.11  NP_665685.11 
     1587948075 
    chicken
    (Gallus gallus)
    Aves DHX351 DEAH (Asp-Glu-Ala-His) box polypeptide 35 79.77(n)
    90.17(a)
      419172  XM_004947002.1  XP_004947059.1 
    lizard
    (Anolis carolinensis)
    Reptilia DHX356
    DEAH (Asp-Glu-Ala-His) box polypeptide 35
    77(a)
    1 ↔ 1
    4(140859207-140911417)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dhx351 DEAH (Asp-Glu-Ala-His) box polypeptide 35 73.9(n)
    84.43(a)
      779970  NM_001079047.1  NP_001072515.1 
    zebrafish
    (Danio rerio)
    Actinopterygii DHX356
    DEAH (Asp-Glu-Ala-His) box polypeptide 35
    77(a)
    1 ↔ 1
    23(2927690-2945990) ENSDARG00000063419
    fruit fly
    (Drosophila melanogaster)
    Insecta CG32251 CG3225 54.59(n)
    50.08(a)
      33680  NM_135016.3  NP_608860.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y67D2.61 Y67D2.6 56.68(n)
    53.95(a)
      175308  NM_065019.3  NP_497420.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G184651 AT4G18465 54.98(n)
    51.64(a)
      827579  NM_117961.2  NP_567558.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g02121001 Os01g0212100 54.17(n)
    51.41(a)
      4325567  NM_001048912.1  NP_001042377.1 


    ENSEMBL Gene Tree for DHX35 (if available)
    TreeFam Gene Tree for DHX35 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DHX35 gene
    DHX332  DHX162  DHX152  DQX12  DHX322  DHX82  
    11 SIMAP similar genes for DHX35 using alignment to 5 protein entries:     DHX35_HUMAN (see all proteins):
    DHX16    DHX15    DKFZp762F2011    DHX33    DHX8    DHX38
    DHX40    DHX34    DHX32    DHX36    DQX1

    Find genes that share paralogs with DHX35           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DHX35 (see all 1752)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1156877661,2
    F--37588984(+) GTCCTC/TGTCCT 3 -- us2k11Minor allele frequency- T:0.01WA 118
    rs48102461,2
    C,F,H--37589016(+) GTGGCG/AGCAGG 3 -- us2k15Minor allele frequency- A:0.15NS EA NA 538
    rs1904360131,2
    C--37589031(+) CCACAA/GATCAA 3 -- us2k10--------
    rs124807141,2
    H--37589087(+) TAGGCA/TCTGTT 3 -- us2k10--------
    rs1384709911,2
    C--37589170(+) AGTGGA/CGGCAG 3 -- us2k10--------
    rs622041301,2
    F--37589190(+) AGATCC/AACTAA 3 -- us2k12Minor allele frequency- A:0.33NA CSA 3
    rs560611471,2
    C--37589194(+) CAACTA/GAAACT 3 -- us2k10--------
    rs556506931,2
    C--37589200(+) AAACTA/GAGCCT 3 -- us2k10--------
    rs559087081,2
    C--37589307(+) TAGTGA/GCGGCA 3 -- us2k10--------
    rs1397860841,2
    --37589389(+) TGGGCC/TACGAA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for DHX35 (37590942 - 37668366 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DHX35:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833973CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DHX35
    DNA2.0 Custom Variant and Variant Library Synthesis for DHX35

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with DHX35           About GenesLikeMe

    Genetic Association Database (GAD): DHX35
    Human Genome Epidemiology (HuGE) Navigator: DHX35 (1 document)

    Export disorders for DHX35 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DHX35 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with DHX35)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    5. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PubMed id 21546767)1 Murea M....Freedman B.I. (Am. J. Nephrol. 2011)
    8. A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer. (PubMed id 21460395)1 Gu J....Wu X. (Cancer Prev Res (Phila) 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 60625 HGNC: 15861 AceView: DHX35 Ensembl:ENSG00000101452 euGenes: HUgn60625
    ECgene: DHX35 H-InvDB: DHX35

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DHX35 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DHX35 gene:
    Search GeneIP for patents involving DHX35

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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