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Aliases for DHX35 Gene

Aliases for DHX35 Gene

  • DEAH-Box Helicase 35 2 3
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 35 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 35 2 3
  • DEAH Box Protein 35 3 4
  • C20orf15 3 4
  • DDX35 3 4
  • DEAH-Box Protein 35 3
  • EC 3.6.4.13 4
  • KAIA0875 3
  • EC 3.6.1 63

External Ids for DHX35 Gene

Previous HGNC Symbols for DHX35 Gene

  • C20orf15
  • DDX35

Previous GeneCards Identifiers for DHX35 Gene

  • GC20P038229
  • GC20P038276
  • GC20P037024
  • GC20P037590
  • GC20P034328

Summaries for DHX35 Gene

Entrez Gene Summary for DHX35 Gene

  • DEAD box proteins characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The function of this gene product which is a member of this family, has not been determined. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for DHX35 Gene

DHX35 (DEAH-Box Helicase 35) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DHX16.

UniProtKB/Swiss-Prot for DHX35 Gene

  • May be involved in pre-mRNA splicing.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX35 Gene

Genomics for DHX35 Gene

Regulatory Elements for DHX35 Gene

Enhancers for DHX35 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DHX35 on UCSC Golden Path with GeneCards custom track

Promoters for DHX35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DHX35 on UCSC Golden Path with GeneCards custom track

Genomic Location for DHX35 Gene

Chromosome:
20
Start:
38,962,299 bp from pter
End:
39,039,723 bp from pter
Size:
77,425 bases
Orientation:
Plus strand

Genomic View for DHX35 Gene

Genes around DHX35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX35 Gene

Proteins for DHX35 Gene

  • Protein details for DHX35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H5Z1-DHX35_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DHX35
    Protein Accession:
    Q9H5Z1
    Secondary Accessions:
    • A2RTX3
    • B4E0J0
    • F5GXM6
    • Q5THR0
    • Q9H4H7
    • Q9H6T6

    Protein attributes for DHX35 Gene

    Size:
    703 amino acids
    Molecular mass:
    78910 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.
    SequenceCaution:
    • Sequence=BAB15166.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DHX35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHX35 Gene

Proteomics data for DHX35 Gene at MOPED

Selected DME Specific Peptides for DHX35 Gene

Post-translational modifications for DHX35 Gene

  • Ubiquitination at Lys 326, Lys 413, Lys 435, and Lys 591
  • Modification sites at PhosphoSitePlus

Other Protein References for DHX35 Gene

Domains & Families for DHX35 Gene

Gene Families for DHX35 Gene

Suggested Antigen Peptide Sequences for DHX35 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H5Z1

UniProtKB/Swiss-Prot:

DHX35_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DEAH subfamily.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX35: view

Function for DHX35 Gene

Molecular function for DHX35 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
May be involved in pre-mRNA splicing.

Enzyme Numbers (IUBMB) for DHX35 Gene

Gene Ontology (GO) - Molecular Function for DHX35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0008026 ATP-dependent helicase activity IEA --
GO:0044822 poly(A) RNA binding IBA --
genes like me logo Genes that share ontologies with DHX35: view
genes like me logo Genes that share phenotypes with DHX35: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DHX35

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHX35 Gene

Localization for DHX35 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHX35 Gene COMPARTMENTS Subcellular localization image for DHX35 gene
Compartment Confidence
nucleus 5
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DHX35 Gene

Pathways & Interactions for DHX35 Gene

SuperPathways for DHX35 Gene

No Data Available

Interacting Proteins for DHX35 Gene

Gene Ontology (GO) - Biological Process for DHX35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with DHX35: view

No data available for Pathways by source and SIGNOR curated interactions for DHX35 Gene

Drugs & Compounds for DHX35 Gene

(1) Drugs for DHX35 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DHX35 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DHX35: view

Transcripts for DHX35 Gene

Unigene Clusters for DHX35 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 35:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHX35 Gene

No ASD Table

Relevant External Links for DHX35 Gene

GeneLoc Exon Structure for
DHX35
ECgene alternative splicing isoforms for
DHX35

Expression for DHX35 Gene

mRNA expression in normal human tissues for DHX35 Gene

Protein differential expression in normal tissues from HIPED for DHX35 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (34.8) and Placenta (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHX35 Gene



SOURCE GeneReport for Unigene cluster for DHX35 Gene Hs.444520

genes like me logo Genes that share expression patterns with DHX35: view

Protein tissue co-expression partners for DHX35 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DHX35 Gene

Orthologs for DHX35 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX35 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DHX35 35
  • 90.31 (n)
  • 96.44 (a)
DHX35 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DHX35 35
  • 91.3 (n)
  • 96.31 (a)
DHX35 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dhx35 35
  • 88.35 (n)
  • 94.99 (a)
Dhx35 16
Dhx35 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DHX35 35
  • 99 (n)
  • 98.72 (a)
DHX35 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dhx35 35
  • 88.35 (n)
  • 94.99 (a)
oppossum
(Monodelphis domestica)
Mammalia DHX35 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DHX35 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves DHX35 35
  • 79.77 (n)
  • 90.17 (a)
DHX35 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHX35 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx35 35
  • 73.9 (n)
  • 84.43 (a)
zebrafish
(Danio rerio)
Actinopterygii DHX35 36
  • 77 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010872 35
  • 54.34 (n)
  • 53.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3225 35
  • 54.59 (n)
  • 50.08 (a)
CG3225 36
  • 49 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y67D2.6 35
  • 56.68 (n)
  • 53.95 (a)
Y67D2.6 36
  • 51 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G18465 35
  • 54.98 (n)
  • 51.64 (a)
rice
(Oryza sativa)
Liliopsida Os01g0212100 35
  • 54.17 (n)
  • 51.41 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06735 35
  • 55.17 (n)
  • 53.26 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC20H4.09 35
  • 49.76 (n)
  • 42.6 (a)
Species with no ortholog for DHX35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHX35 Gene

ENSEMBL:
Gene Tree for DHX35 (if available)
TreeFam:
Gene Tree for DHX35 (if available)

Paralogs for DHX35 Gene

Paralogs for DHX35 Gene

(11) SIMAP similar genes for DHX35 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DHX35: view

Variants for DHX35 Gene

Sequence variations from dbSNP and Humsavar for DHX35 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs3752302 - 39,038,539(+) GGACC(C/T)GTGAG nc-transcript-variant, reference, missense
rs36053162 - 38,992,409(-) AGCCA(A/G)TGGCA nc-transcript-variant, reference, missense
rs6729 -- 39,039,629(+) ATGTC(A/G)TTTTT nc-transcript-variant, utr-variant-3-prime
rs974559 -- 38,962,718(-) ACGAG(A/G)GGGAG intron-variant, upstream-variant-2KB
rs974560 -- 38,962,555(-) CCTGA(A/G)CCAGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DHX35 Gene

Variant ID Type Subtype PubMed ID
nsv833973 CNV Loss 17160897

Variation tolerance for DHX35 Gene

Residual Variation Intolerance Score: 15.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.71; 86.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHX35 Gene

HapMap Linkage Disequilibrium report
DHX35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX35 Gene

Disorders for DHX35 Gene

Relevant External Links for DHX35

Genetic Association Database (GAD)
DHX35
Human Genome Epidemiology (HuGE) Navigator
DHX35
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHX35

No disorders were found for DHX35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX35 Gene

Publications for DHX35 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3

Products for DHX35 Gene

Sources for DHX35 Gene

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