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Aliases for DHX35 Gene

Aliases for DHX35 Gene

  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 35 2 3
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 35 2 3
  • DEAH Box Protein 35 3 4
  • C20orf15 3 4
  • DDX35 3 4
  • Probable ATP-Dependent RNA Helicase DHX35 3
  • DEAH-Box Protein 35 3
  • EC 4
  • KAIA0875 3
  • EC 3.6.1 63

External Ids for DHX35 Gene

Previous HGNC Symbols for DHX35 Gene

  • C20orf15
  • DDX35

Previous GeneCards Identifiers for DHX35 Gene

  • GC20P038229
  • GC20P038276
  • GC20P037024
  • GC20P037590
  • GC20P034328

Summaries for DHX35 Gene

Entrez Gene Summary for DHX35 Gene

  • DEAD box proteins characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The function of this gene product which is a member of this family, has not been determined. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for DHX35 Gene

DHX35 (DEAH (Asp-Glu-Ala-His) Box Polypeptide 35) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and ATP-dependent helicase activity. An important paralog of this gene is DHX16.

UniProtKB/Swiss-Prot for DHX35 Gene

  • May be involved in pre-mRNA splicing

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX35 Gene

Genomics for DHX35 Gene

Regulatory Elements for DHX35 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DHX35 Gene

38,962,299 bp from pter
39,039,723 bp from pter
77,425 bases
Plus strand

Genomic View for DHX35 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHX35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX35 Gene

Proteins for DHX35 Gene

  • Protein details for DHX35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ATP-dependent RNA helicase DHX35
    Protein Accession:
    Secondary Accessions:
    • A2RTX3
    • B4E0J0
    • F5GXM6
    • Q5THR0
    • Q9H4H7
    • Q9H6T6

    Protein attributes for DHX35 Gene

    703 amino acids
    Molecular mass:
    78910 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.
    • Sequence=BAB15166.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DHX35 Gene


neXtProt entry for DHX35 Gene

Proteomics data for DHX35 Gene at MOPED

Selected DME Specific Peptides for DHX35 Gene

Post-translational modifications for DHX35 Gene

  • Ubiquitination at Lys9, Lys326, Lys413, Lys435, and Lys591
  • Modification sites at PhosphoSitePlus

Other Protein References for DHX35 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for DHX35

Domains for DHX35 Gene

Gene Families for DHX35 Gene

Suggested Antigen Peptide Sequences for DHX35 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DEAH subfamily.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX35: view

Function for DHX35 Gene

Molecular function for DHX35 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function:
May be involved in pre-mRNA splicing

Enzyme Numbers (IUBMB) for DHX35 Gene

Gene Ontology (GO) - Molecular Function for DHX35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity --
GO:0005524 ATP binding IEA --
GO:0008026 ATP-dependent helicase activity --
genes like me logo Genes that share ontologies with DHX35: view

Phenotypes for DHX35 Gene

genes like me logo Genes that share phenotypes with DHX35: view

Animal Model Products

miRNA for DHX35 Gene

miRTarBase miRNAs that target DHX35

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for DHX35 Gene

Localization for DHX35 Gene

Subcellular locations from

Jensen Localization Image for DHX35 Gene COMPARTMENTS Subcellular localization image for DHX35 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for DHX35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with DHX35: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DHX35 Gene

Pathways for DHX35 Gene

SuperPathways for DHX35 Gene

No Data Available

Interacting Proteins for DHX35 Gene

Gene Ontology (GO) - Biological Process for DHX35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0006200 obsolete ATP catabolic process --
GO:0006396 RNA processing IBA --
genes like me logo Genes that share ontologies with DHX35: view

No data available for Pathways by source for DHX35 Gene

Drugs for DHX35 Gene

(4) HMDB Compounds for DHX35 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(Tetrahydrogen triphosphate) Adenosine
  • Adenosindiphosphorsaeure
Phosphoric acid
  • Acide phosphorique (FRENCH)
  • Dihydrogen oxide
genes like me logo Genes that share compounds with DHX35: view

Transcripts for DHX35 Gene

Unigene Clusters for DHX35 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 35:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHX35 Gene

No ASD Table

Relevant External Links for DHX35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHX35 Gene

mRNA expression in normal human tissues for DHX35 Gene

Protein differential expression in normal tissues for DHX35 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (34.8) and Placenta (13.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHX35 Gene

SOURCE GeneReport for Unigene cluster for DHX35 Gene Hs.444520

genes like me logo Genes that share expressions with DHX35: view

Expression partners for DHX35 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DHX35 Gene

Orthologs for DHX35 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX35 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DHX35 35
  • 90.31 (n)
  • 96.44 (a)
DHX35 36
  • 96 (a)
(Canis familiaris)
Mammalia DHX35 35
  • 91.3 (n)
  • 96.31 (a)
DHX35 36
  • 94 (a)
(Mus musculus)
Mammalia Dhx35 35
  • 88.35 (n)
  • 94.99 (a)
Dhx35 16
Dhx35 36
  • 95 (a)
(Pan troglodytes)
Mammalia DHX35 35
  • 99 (n)
  • 98.72 (a)
DHX35 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Dhx35 35
  • 88.35 (n)
  • 94.99 (a)
(Monodelphis domestica)
Mammalia DHX35 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia DHX35 36
  • 91 (a)
(Gallus gallus)
Aves DHX35 35
  • 79.77 (n)
  • 90.17 (a)
DHX35 36
  • 90 (a)
(Anolis carolinensis)
Reptilia DHX35 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx35 35
  • 73.9 (n)
  • 84.43 (a)
(Danio rerio)
Actinopterygii DHX35 36
  • 77 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010872 35
  • 54.34 (n)
  • 53.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3225 35
  • 54.59 (n)
  • 50.08 (a)
CG3225 36
  • 49 (a)
(Caenorhabditis elegans)
Secernentea Y67D2.6 35
  • 56.68 (n)
  • 53.95 (a)
Y67D2.6 36
  • 51 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G18465 35
  • 54.98 (n)
  • 51.64 (a)
(Oryza sativa)
Liliopsida Os01g0212100 35
  • 54.17 (n)
  • 51.41 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06735 35
  • 55.17 (n)
  • 53.26 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC20H4.09 35
  • 49.76 (n)
  • 42.6 (a)
Species with no ortholog for DHX35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHX35 Gene

Gene Tree for DHX35 (if available)
Gene Tree for DHX35 (if available)

Paralogs for DHX35 Gene

Paralogs for DHX35 Gene

(11) SIMAP similar genes for DHX35 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DHX35: view

Variants for DHX35 Gene

Sequence variations from dbSNP and Humsavar for DHX35 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs6729 -- 39,039,629(+) ATGTC(A/G)TTTTT utr-variant-3-prime, nc-transcript-variant
rs731343 -- 38,988,090(-) GATTC(A/C)CCCTG intron-variant
rs731344 -- 38,988,152(-) AGCCA(C/T)AAATT intron-variant
rs760844 -- 38,988,332(-) TTATG(C/T)ATCTC intron-variant
rs974559 -- 38,962,718(-) ACGAG(A/G)GGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHX35 Gene

Variant ID Type Subtype PubMed ID
nsv833973 CNV Loss 17160897

Relevant External Links for DHX35 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX35 Gene

Disorders for DHX35 Gene

Relevant External Links for DHX35

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for DHX35 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DHX35 Gene

Publications for DHX35 Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  2. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer. (PMID: 21460395) Gu J. … Wu X. (Cancer Prev Res (Phila) 2011) 3

Products for DHX35 Gene

Sources for DHX35 Gene

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