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Aliases for DHX34 Gene

Aliases for DHX34 Gene

  • DExH-Box Helicase 34 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 34 2 3
  • DEAH-Box Helicase 34 2 3
  • DEAH Box Protein 34 3 4
  • DDX34 3 4
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 34 3
  • Probable ATP-Dependent RNA Helicase DHX34 3
  • Probable ATP-Dependent Helicase DHX34 3
  • EC 4
  • KIAA0134 4
  • EC 3.6.1 58
  • HRH1 3

External Ids for DHX34 Gene

Previous HGNC Symbols for DHX34 Gene

  • DDX34

Previous GeneCards Identifiers for DHX34 Gene

  • GC19P052532
  • GC19P052547
  • GC19P052544
  • GC19P047853
  • GC19P044277

Summaries for DHX34 Gene

Entrez Gene Summary for DHX34 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. It is mapped to the glioma 19q tumor suppressor region and is a tumor suppressor candidate gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DHX34 Gene

DHX34 (DExH-Box Helicase 34) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and helicase activity.

UniProtKB/Swiss-Prot for DHX34 Gene

  • Probable ATP-binding RNA helicase.

Additional gene information for DHX34 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX34 Gene

Genomics for DHX34 Gene

Regulatory Elements for DHX34 Gene

Enhancers for DHX34 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H047369 1.2 FANTOM5 Ensembl ENCODE 57.7 +21.1 21096 2 CTCF PKNOX1 MAX FOS ZIC2 MYC MAFK DHX34 C5AR1 ZC3H4 C5AR2 CCDC9 NAPA GC19P047388 GC19P047354 PIR41927
GH19H047388 1.2 FANTOM5 Ensembl ENCODE 47.5 +40.1 40098 2 PKNOX1 RFX1 CREB1 MAX MNT MYC DHX34 C5AR1 C5AR2 ZC3H4 CCDC9 NAPA BICRA BBC3 GC19P047388 MEIS3
GH19H047383 1.4 FANTOM5 Ensembl ENCODE 27.2 +34.3 34320 1.2 HDGF ATF1 ZBTB21 BACH1 ZNF644 ZNF121 ZFHX2 ZNF316 CTBP1 EGR1 ZC3H4 DHX34 C5AR1 CCDC9 BICRA NOP53-AS1 SNORD23 NAPA C5AR2 NOP53
GH19H047363 1 FANTOM5 ENCODE 37 +14.9 14902 1.5 SP3 HCFC1 SUZ12 NRF1 BHLHE40 MAX SIX5 MNT ZNF217 ZNF143 DHX34 C5AR1 ZC3H4 C5AR2 CCDC9 NAPA PIR41927 GC19P047354 GC19P047388
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DHX34 on UCSC Golden Path with GeneCards custom track

Promoters for DHX34 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110543 219 1401 HDGF FOXA2 PKNOX1 MLX ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF143

Transcription factor binding sites by QIAGEN in the DHX34 gene promoter:

Genomic Locations for DHX34 Gene

Genomic Locations for DHX34 Gene
33,424 bases
Plus strand

Genomic View for DHX34 Gene

Genes around DHX34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX34 Gene

Proteins for DHX34 Gene

  • Protein details for DHX34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ATP-dependent RNA helicase DHX34
    Protein Accession:
    Secondary Accessions:
    • B4DMY8

    Protein attributes for DHX34 Gene

    1143 amino acids
    Molecular mass:
    128120 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA09483.2; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=BAG60050.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for DHX34 Gene

Selected DME Specific Peptides for DHX34 Gene


Post-translational modifications for DHX34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHX34 Gene

Domains & Families for DHX34 Gene

Gene Families for DHX34 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DHX34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DEAD box helicase family. DEAH subfamily.
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX34: view

Function for DHX34 Gene

Molecular function for DHX34 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Probable ATP-binding RNA helicase.

Enzyme Numbers (IUBMB) for DHX34 Gene

Gene Ontology (GO) - Molecular Function for DHX34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA,IDA 22681889
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DHX34: view
genes like me logo Genes that share phenotypes with DHX34: view

Animal Model Products

miRNA for DHX34 Gene

miRTarBase miRNAs that target DHX34

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHX34 Gene

Localization for DHX34 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHX34 gene
Compartment Confidence
nucleus 4
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (1)
  • Nucleus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DHX34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DHX34: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DHX34 Gene

Pathways & Interactions for DHX34 Gene

SuperPathways for DHX34 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHX34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000956 nuclear-transcribed mRNA catabolic process IMP 23828042
GO:0006396 RNA processing IBA --
GO:2000623 negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP 23828042
genes like me logo Genes that share ontologies with DHX34: view

No data available for Pathways by source and SIGNOR curated interactions for DHX34 Gene

Drugs & Compounds for DHX34 Gene

(3) Drugs for DHX34 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Nutra Agonist 0

(1) Additional Compounds for DHX34 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DHX34: view

Transcripts for DHX34 Gene

Unigene Clusters for DHX34 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 34:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX34 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP8: - -
SP9: -

ExUns: 20 ^ 21 ^ 22 ^ 23

Relevant External Links for DHX34 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHX34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHX34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DHX34 Gene

This gene is overexpressed in Whole Blood (x13.2).

Protein differential expression in normal tissues from HIPED for DHX34 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.3), Salivary gland (9.8), Adrenal (8.6), and Testis (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DHX34 Gene

NURSA nuclear receptor signaling pathways regulating expression of DHX34 Gene:


SOURCE GeneReport for Unigene cluster for DHX34 Gene:


Evidence on tissue expression from TISSUES for DHX34 Gene

  • Bone marrow(4.2)
  • Lung(4.2)
  • Liver(4.1)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with DHX34: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHX34 Gene

Orthologs for DHX34 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DHX34 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DHX34 33 34
  • 99.42 (n)
(Bos Taurus)
Mammalia DHX34 33 34
  • 87.69 (n)
(Canis familiaris)
Mammalia DHX34 33 34
  • 87.62 (n)
(Rattus norvegicus)
Mammalia Dhx34 33
  • 84.97 (n)
(Mus musculus)
Mammalia Dhx34 33 16 34
  • 84.87 (n)
(Monodelphis domestica)
Mammalia DHX34 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia DHX34 34
  • 67 (a)
(Anolis carolinensis)
Reptilia DHX34 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx34 33
  • 61.54 (n)
(Danio rerio)
Actinopterygii dhx34 33 34
  • 62.59 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001338 33
  • 55.16 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32533 33 34
  • 55.04 (n)
(Caenorhabditis elegans)
Secernentea smgl-2 33 34
  • 48.95 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP2 34
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 51 (a)
Species where no ortholog for DHX34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHX34 Gene

Gene Tree for DHX34 (if available)
Gene Tree for DHX34 (if available)

Paralogs for DHX34 Gene

(6) SIMAP similar genes for DHX34 Gene using alignment to 2 proteins: Pseudogenes for DHX34 Gene

genes like me logo Genes that share paralogs with DHX34: view

No data available for Paralogs for DHX34 Gene

Variants for DHX34 Gene

Sequence variations from dbSNP and Humsavar for DHX34 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000183111 -- 47,362,888(+) ACCTC(C/T)ACCTG intron-variant
rs1000239821 -- 47,364,505(+) GGGAG(C/G)CTGAG intron-variant
rs1000273276 -- 47,365,495(+) GATCT(A/G)CCTGC intron-variant
rs1000286981 -- 47,359,378(+) GATCG(A/C)ATGAG intron-variant
rs1000376121 -- 47,379,144(+) TAAAT(-/TAATAATAA)TAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHX34 Gene

Variant ID Type Subtype PubMed ID
nsv9738 CNV gain 18304495
nsv961229 CNV duplication 23825009
nsv521341 CNV gain 19592680
nsv517901 CNV loss 19592680
nsv516890 CNV loss 19592680
nsv479067 CNV novel sequence insertion 20440878
nsv474975 CNV novel sequence insertion 20440878
nsv474520 CNV novel sequence insertion 20440878
nsv428366 CNV loss 18775914
nsv1062949 CNV gain 25217958
esv3583445 CNV loss 25503493
esv2758765 CNV loss 17122850

Variation tolerance for DHX34 Gene

Residual Variation Intolerance Score: 45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.48; 77.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHX34 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX34 Gene

Disorders for DHX34 Gene

Relevant External Links for DHX34

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DHX34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX34 Gene

Publications for DHX34 Gene

  1. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1995) 2 3 4 60
  2. A transcript map of the chromosome 19q-arm glioma tumor suppressor region. (PMID: 10708517) Smith JS … Jenkins RB (Genomics 2000) 2 3 60
  3. The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation. (PMID: 26841701) Melero R … Llorca O (Nature communications 2016) 3 60
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  5. The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex. (PMID: 25220460) Hug N … Cáceres JF (Cell reports 2014) 3 60

Products for DHX34 Gene

Sources for DHX34 Gene

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