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Aliases for DHX34 Gene

Aliases for DHX34 Gene

  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 34 2 3
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 34 2 3
  • DEAH Box Protein 34 3 4
  • KIAA0134 4 6
  • DDX34 3 4
  • Probable ATP-Dependent RNA Helicase DHX34 3
  • Probable ATP-Dependent Helicase DHX34 3
  • EC 3.6.4.13 4
  • EC 3.6.1 64
  • HRH1 3

External Ids for DHX34 Gene

Previous Symbols for DHX34 Gene

  • DDX34

Summaries for DHX34 Gene

Entrez Gene Summary for DHX34 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. It is mapped to the glioma 19q tumor suppressor region and is a tumor suppressor candidate gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DHX34 Gene

DHX34 (DEAH (Asp-Glu-Ala-His) Box Polypeptide 34) is a Protein Coding gene. Diseases associated with DHX34 include atopic dermatitis and asthma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include RNA binding and ATP-dependent helicase activity.

UniProtKB/Swiss-Prot for DHX34 Gene

  • Probable ATP-binding RNA helicase

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX34 Gene

Genomics for DHX34 Gene

Genomic Location for DHX34 Gene

Start:
47,349,281 bp from pter
End:
47,382,704 bp from pter
Size:
33,424 bases
Orientation:
Plus strand

Genomic View for DHX34 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHX34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX34 Gene

Regulatory Elements for DHX34 Gene

Transcription factor binding sites by QIAGEN in the DHX34 gene promoter:

Proteins for DHX34 Gene

  • Protein details for DHX34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14147-DHX34_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DHX34
    Protein Accession:
    Q14147
    Secondary Accessions:
    • B4DMY8

    Protein attributes for DHX34 Gene

    Size:
    1143 amino acids
    Molecular mass:
    128120 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA09483.2; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=BAG60050.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for DHX34 Gene

Proteomics data for DHX34 Gene at MOPED

Selected DME Specific Peptides for DHX34 Gene

Post-translational modifications for DHX34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHX34 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for DHX34 Gene

Gene Families for DHX34 Gene

HGNC:
  • DHX :DEAH-boxes

UniProtKB/Swiss-Prot:

DHX34_HUMAN
Domain:
  • Contains 1 helicase ATP-binding domain.:
    • Q14147
  • Contains 1 helicase C-terminal domain.:
    • Q14147
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily.:
    • Q14147
genes like me logo Genes that share domains with DHX34: view

Function for DHX34 Gene

Molecular function for DHX34 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: Probable ATP-binding RNA helicase

Enzyme Numbers (IUBMB) for DHX34 Gene

Gene Ontology (GO) - Molecular Function for DHX34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity --
GO:0005524 ATP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with DHX34: view

Phenotypes for DHX34 Gene

GenomeRNAi human phenotypes for DHX34:
genes like me logo Genes that share phenotypes with DHX34: view

miRNA for DHX34 Gene

miRTarBase miRNAs that target DHX34

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DHX34 Gene

Localization for DHX34 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHX34 Gene COMPARTMENTS Subcellular localization image for DHX34 gene
Compartment Confidence
nucleus 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for DHX34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DHX34: view

Pathways for DHX34 Gene

genes like me logo Genes that share pathways with DHX34: view

Gene Ontology (GO) - Biological Process for DHX34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000956 nuclear-transcribed mRNA catabolic process IMP 23828042
GO:0006396 RNA processing IBA --
GO:2000623 negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP 23828042
genes like me logo Genes that share ontologies with DHX34: view

Transcripts for DHX34 Gene

Unigene Clusters for DHX34 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 34:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHX34 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9: -
SP10:

ExUns: 20 ^ 21 ^ 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for DHX34 Gene

GeneLoc Exon Structure for
DHX34
ECgene alternative splicing isoforms for
DHX34

Expression for DHX34 Gene

mRNA expression in normal human tissues for DHX34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DHX34 Gene

This gene is overexpressed in Whole Blood (13.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DHX34 Gene

SOURCE GeneReport for Unigene cluster for DHX34 Gene Hs.151706

genes like me logo Genes that share expressions with DHX34: view

Orthologs for DHX34 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DHX34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHX34 36
  • 99.42 (n)
  • 99.39 (a)
DHX34 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DHX34 36
  • 87.69 (n)
  • 88.71 (a)
DHX34 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DHX34 36
  • 87.62 (n)
  • 89.7 (a)
DHX34 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dhx34 36
  • 84.87 (n)
  • 88.24 (a)
Dhx34 16
Dhx34 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DHX34 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DHX34 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dhx34 36
  • 84.97 (n)
  • 88.22 (a)
lizard
(Anolis carolinensis)
Reptilia DHX34 37
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx34 36
  • 61.54 (n)
  • 63.28 (a)
zebrafish
(Danio rerio)
Actinopterygii dhx34 36
  • 62.59 (n)
  • 61.75 (a)
dhx34 37
  • 56 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001338 36
  • 55.16 (n)
  • 48.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32533 36
  • 55.04 (n)
  • 46.09 (a)
CG32533 37
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea smgl-2 36
  • 48.95 (n)
  • 44.83 (a)
smgl-2 37
  • 37 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP2 37
  • 28 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 51 (a)
OneToOne
Species with no ortholog for DHX34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHX34 Gene

ENSEMBL:
Gene Tree for DHX34 (if available)
TreeFam:
Gene Tree for DHX34 (if available)

Paralogs for DHX34 Gene

Selected SIMAP similar genes for DHX34 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for DHX34 Gene

genes like me logo Genes that share paralogs with DHX34: view

No data available for Paralogs for DHX34 Gene

Variants for DHX34 Gene

Sequence variations from dbSNP and Humsavar for DHX34 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs744734 -- 47,378,656(+) gagac(A/T)ctatc intron-variant
rs744735 -- 47,378,663(+) tatct(A/G)tctct intron-variant
rs744736 -- 47,378,750(+) aggat(C/T)gcttg intron-variant
rs745201 -- 47,379,335(-) AATTA(C/G)CAGTG intron-variant
rs755326 -- 47,374,717(-) GAGCA(A/T)TCGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHX34 Gene

Variant ID Type Subtype PubMed ID
nsv912200 CNV Loss 21882294
dgv1107e1 CNV Complex 17122850
nsv428366 CNV Loss 18775914
nsv912201 CNV Loss 21882294
nsv9738 CNV Gain 18304495
nsv516890 CNV Loss 19592680
nsv521341 CNV Gain 19592680
nsv517901 CNV Loss 19592680

Relevant External Links for DHX34 Gene

HapMap Linkage Disequilibrium report
DHX34

Disorders for DHX34 Gene

genes like me logo Genes that share disorders with DHX34: view

No data available for UniProtKB/Swiss-Prot for DHX34 Gene

Publications for DHX34 Gene

  1. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4
  2. A transcript map of the chromosome 19q-Arm glioma tumor suppressor region. (PMID: 10708517) Smith J.S. … Jenkins R.B. (Genomics 2000) 2 3
  3. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E. … Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3

Products for DHX34 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate DHX34
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for DHX34
    • Block miRNA regulation of DHX34 using miScript Target Protectors

    Sources for DHX34 Gene

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