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Aliases for DHX34 Gene

Aliases for DHX34 Gene

  • DEAH-Box Helicase 34 2 3
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 34 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 34 2 3
  • DEAH Box Protein 34 3 4
  • DDX34 3 4
  • Probable ATP-Dependent Helicase DHX34 3
  • EC 4
  • KIAA0134 4
  • EC 3.6.1 63
  • HRH1 3

External Ids for DHX34 Gene

Previous HGNC Symbols for DHX34 Gene

  • DDX34

Previous GeneCards Identifiers for DHX34 Gene

  • GC19P052532
  • GC19P052547
  • GC19P052544
  • GC19P047853
  • GC19P044277

Summaries for DHX34 Gene

Entrez Gene Summary for DHX34 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. It is mapped to the glioma 19q tumor suppressor region and is a tumor suppressor candidate gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DHX34 Gene

DHX34 (DEAH-Box Helicase 34) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DHX16.

UniProtKB/Swiss-Prot for DHX34 Gene

  • Probable ATP-binding RNA helicase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX34 Gene

Genomics for DHX34 Gene

Regulatory Elements for DHX34 Gene

Enhancers for DHX34 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DHX34 on UCSC Golden Path with GeneCards custom track

Promoters for DHX34 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DHX34 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the DHX34 gene promoter:

Genomic Location for DHX34 Gene

47,349,281 bp from pter
47,382,704 bp from pter
33,424 bases
Plus strand

Genomic View for DHX34 Gene

Genes around DHX34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX34 Gene

Proteins for DHX34 Gene

  • Protein details for DHX34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ATP-dependent RNA helicase DHX34
    Protein Accession:
    Secondary Accessions:
    • B4DMY8

    Protein attributes for DHX34 Gene

    1143 amino acids
    Molecular mass:
    128120 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA09483.2; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=BAG60050.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for DHX34 Gene

Proteomics data for DHX34 Gene at MOPED

Selected DME Specific Peptides for DHX34 Gene

Post-translational modifications for DHX34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHX34 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for DHX34 Gene

Gene Families for DHX34 Gene

Suggested Antigen Peptide Sequences for DHX34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DEAH subfamily.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX34: view

Function for DHX34 Gene

Molecular function for DHX34 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Probable ATP-binding RNA helicase.

Enzyme Numbers (IUBMB) for DHX34 Gene

Gene Ontology (GO) - Molecular Function for DHX34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with DHX34: view
genes like me logo Genes that share phenotypes with DHX34: view

Animal Model Products

miRNA for DHX34 Gene

miRTarBase miRNAs that target DHX34

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHX34 Gene

Localization for DHX34 Gene

Subcellular locations from

Jensen Localization Image for DHX34 Gene COMPARTMENTS Subcellular localization image for DHX34 gene
Compartment Confidence
nucleus 4
mitochondrion 3
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DHX34 Gene

Pathways & Interactions for DHX34 Gene

SuperPathways for DHX34 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHX34 Gene


No data available for Pathways by source and SIGNOR curated interactions for DHX34 Gene

Drugs & Compounds for DHX34 Gene

(1) Drugs for DHX34 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DHX34 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with DHX34: view

Transcripts for DHX34 Gene

Unigene Clusters for DHX34 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 34:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHX34 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP8: - -
SP9: -

ExUns: 20 ^ 21 ^ 22 ^ 23

Relevant External Links for DHX34 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHX34 Gene

mRNA expression in normal human tissues for DHX34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DHX34 Gene

This gene is overexpressed in Whole Blood (x13.2).

Protein differential expression in normal tissues from HIPED for DHX34 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.3), Salivary gland (9.8), Adrenal (8.6), and Testis (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DHX34 Gene

SOURCE GeneReport for Unigene cluster for DHX34 Gene Hs.151706

genes like me logo Genes that share expression patterns with DHX34: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DHX34 Gene

Orthologs for DHX34 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DHX34 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DHX34 35
  • 87.69 (n)
  • 88.71 (a)
DHX34 36
  • 88 (a)
(Canis familiaris)
Mammalia DHX34 35
  • 87.62 (n)
  • 89.7 (a)
DHX34 36
  • 89 (a)
(Mus musculus)
Mammalia Dhx34 35
  • 84.87 (n)
  • 88.24 (a)
Dhx34 16
Dhx34 36
  • 87 (a)
(Pan troglodytes)
Mammalia DHX34 35
  • 99.42 (n)
  • 99.39 (a)
DHX34 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Dhx34 35
  • 84.97 (n)
  • 88.22 (a)
(Monodelphis domestica)
Mammalia DHX34 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia DHX34 36
  • 67 (a)
(Anolis carolinensis)
Reptilia DHX34 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx34 35
  • 61.54 (n)
  • 63.28 (a)
(Danio rerio)
Actinopterygii dhx34 35
  • 62.59 (n)
  • 61.75 (a)
dhx34 36
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001338 35
  • 55.16 (n)
  • 48.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32533 35
  • 55.04 (n)
  • 46.09 (a)
CG32533 36
  • 41 (a)
(Caenorhabditis elegans)
Secernentea smgl-2 35
  • 48.95 (n)
  • 44.83 (a)
smgl-2 36
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP2 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
Species with no ortholog for DHX34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHX34 Gene

Gene Tree for DHX34 (if available)
Gene Tree for DHX34 (if available)

Paralogs for DHX34 Gene

Paralogs for DHX34 Gene

(6) SIMAP similar genes for DHX34 Gene using alignment to 2 proteins: Pseudogenes for DHX34 Gene

genes like me logo Genes that share paralogs with DHX34: view

Variants for DHX34 Gene

Sequence variations from dbSNP and Humsavar for DHX34 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12984558 - 47,353,079(+) ACCAC(C/T)GGGCT nc-transcript-variant, reference, missense
rs8113564 - 47,353,380(+) GCGGG(A/G)CTCTC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs7257397 -- 47,364,558(+) gcaac(A/T)cggtg intron-variant
rs12979303 -- 47,355,633(+) cacga(A/G)gtcag intron-variant
rs12980929 -- 47,379,162(+) AAGAA(G/T)AAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHX34 Gene

Variant ID Type Subtype PubMed ID
nsv912200 CNV Loss 21882294
dgv1107e1 CNV Complex 17122850
nsv428366 CNV Loss 18775914
nsv912201 CNV Loss 21882294
nsv9738 CNV Gain 18304495
nsv516890 CNV Loss 19592680
nsv521341 CNV Gain 19592680
nsv517901 CNV Loss 19592680

Variation tolerance for DHX34 Gene

Residual Variation Intolerance Score: 45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.48; 77.51% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DHX34 Gene

Disorders for DHX34 Gene

Relevant External Links for DHX34

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DHX34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX34 Gene

Publications for DHX34 Gene

  1. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4 67
  2. A transcript map of the chromosome 19q-Arm glioma tumor suppressor region. (PMID: 10708517) Smith J.S. … Jenkins R.B. (Genomics 2000) 2 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex. (PMID: 25220460) Hug N. … CA!ceres J.F. (Cell Rep 2014) 3
  5. DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans. (PMID: 23828042) Longman D. … CA!ceres J.F. (Nucleic Acids Res. 2013) 3

Products for DHX34 Gene

Sources for DHX34 Gene