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DHX34 Gene

protein-coding   GIFtS: 53
GCID: GC19P047853

DEAH (Asp-Glu-Ala-His) Box Polypeptide 34

(Previous name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 34)
(Previous symbol: DDX34)
  See DHX34-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEAH (Asp-Glu-Ala-His) Box Polypeptide 341 2     HRH12
DDX341 2 3     Probable ATP-Dependent Helicase DHX342
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 341 2     Probable ATP-Dependent RNA Helicase DHX342
DEAH Box Protein 342 3     EC 3.6.4.133
KIAA01343 5     EC 3.6.18

External Ids:    HGNC: 167191   Entrez Gene: 97042   Ensembl: ENSG000001348157   OMIM: 6154755   UniProtKB: Q141473   

Export aliases for DHX34 gene to outside databases

Previous GC identifers: GC19P052532 GC19P052547 GC19P052544 GC19P044277


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DHX34 Gene:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They
are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their
distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis,
spermatogenesis, and cellular growth and division. This gene encodes a member of this family. It is mapped to the
glioma 19q tumor suppressor region and is a tumor suppressor candidate gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for DHX34 Gene:
DHX34 (DEAH (Asp-Glu-Ala-His) box polypeptide 34) is a protein-coding gene. Diseases associated with DHX34 include atopic dermatitis, and dermatitis. GO annotations related to this gene include RNA binding and ATP-dependent helicase activity.

UniProtKB/Swiss-Prot: DHX34_HUMAN, Q14147
Function: Probable ATP-binding RNA helicase

summary for DHX34 Gene:
Histamine H1 receptors are Galphaq/11-protein-coupled receptors that mediate allergic responses. These
receptors are expressed in a wide variety of tissues including the gastrointestinal tract, central nervous
system, airway and vascular smooth muscle cells, endothelial cells, chondrocytes, monocytes, neutrophils,
dendritic cells, T and B lymphocytes, adrenal medulla, and the cardiovascular and genitourinary systems. H1
receptor activation induces a wide range of biological responses due to their widespread distribution. In
smooth muscle, H1 activation increases tension and the contractile response, and in vascular endothelial
cells receptor activation increases cell permeability. In the adrenal medulla, histamine acting at H1
receptors stimulates both adrenalin and noradrenalin release. Furthermore, H1 activation induces
prostacyclin and platelet-activating factor synthesis, promotes von Willebrand factor and nitric oxide
release, liberates arachidonic acid from phospholipids, and causes vasodilation of capillaries and
arterioles. At a physiological level, H1 receptors are involved in a wide array of processes including
thermal regulation, memory and learning, and control of the sleep-wake cycle, food intake, and emotional and
aggressive behaviors. Histamine acting through the H1 receptor has proinflammatory effects, and is involved
in the development of various aspects of the antigen-specific immune response. Activation of these receptors
triggers maturation of dendritic cells and modulates the balance of Th1 and Th2 cells. H1 receptors are
involved in the pathological process of allergy, including allergic rhinits, atopic dermatitis, anaphylaxis
and asthma, and also have a role in autoimmune diseases and malignancy.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DHX34 gene promoter:
         Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDHX34 promoter sequence
   Search Chromatin IP Primers for DHX34

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DHX34


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.3

DHX34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHX34 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P047853:  view genomic region     (about GC identifiers)

Start:
47,852,538 bp from pter      End:
47,885,961 bp from pter
Size:
33,424 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DHX34_HUMAN, Q14147 (See protein sequence)
Recommended Name: Probable ATP-dependent RNA helicase DHX34  
Size: 1143 amino acids; 128120 Da
Sequence caution: Sequence=BAA09483.2; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Sequence=BAG60050.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DMY8

Explore the universe of human proteins at neXtProt for DHX34: NX_Q14147

Explore proteomics data for DHX34 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DHX34 (Q14147) (see all 6)
     TNIAETS  GDTGCGK  VDEVHER  VILMSAT 


    See DHX34 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055496.2  
    ENSEMBL proteins: 
     ENSP00000331907   ENSP00000418656  

    DHX34 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online peptides for DHX34

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    antibodies-online antibodies for DHX34 (6 products) 

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    antibodies-online kits for DHX34 (16 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DHX: DEAH-boxes

    Selected InterPro protein domains (see all 7):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR007502 Helicase-assoc_dom
     IPR015880 Znf_C2H2-like
     IPR011709 DUF1605
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q14147

    ProtoNet protein and cluster: Q14147

    1 Blocks protein domain: IPB002464 ATP-dependent helicase

    UniProtKB/Swiss-Prot: DHX34_HUMAN, Q14147
    Similarity: Belongs to the DEAD box helicase family. DEAH subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Find genes that share domains with DHX34           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DHX34_HUMAN, Q14147
    Function: Probable ATP-binding RNA helicase
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0004386helicase activity ----
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with DHX34           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DHX34:
     Decreased Wnt reporter activit  Proliferating cells 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DHX34

    miRNA
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    miRTarBase miRNAs that target DHX34:
    hsa-mir-320b (MIRT036237)

    Block miRNA regulation of human, mouse, rat DHX34 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidDHX34 3' UTR sequence
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX34

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX34


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytoskeleton1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    Find genes that share ontologies with DHX34           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DHX34
    Interactions:

        Search GeneGlobe Interaction Network for DHX34

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DHX34 (Q141472, 3 ENSP000003319074) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSK3BP498412, 3MINT-8257097 I2D: score=2 
    RPS6KA6Q9UK322, 3MINT-8269802 I2D: score=2 
    POLA2Q141813, ENSP000002654654I2D: score=3 STRING: ENSP00000265465
    CDC5LENSP000003605324STRING: ENSP00000360532
    PRPF19ENSP000002275244STRING: ENSP00000227524
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000956nuclear-transcribed mRNA catabolic process IMP--
    GO:2000623negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP--

    Find genes that share ontologies with DHX34           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for DHX34 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Clemastine fumarateH1 antagonist[14976-57-9]
    Histamine dihydrochlorideEndogenous histamine receptor agonist[56-92-8]
    2-Pyridylethylamine dihydrochlorideH1 receptor agonist[3343-39-3]
    Astemizole Orally active, potent H1 antagonist. Also KV11.1 (hERG) channel blocker. [68844-77-9]
    Mepyramine maleateSelective H1 inverse agonist[59-33-6]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DHX34 gene (2 alternative transcripts): 
    NM_014681.5  NM_194428.1  

    Unigene Cluster for DHX34:

    DEAH (Asp-Glu-Ala-His) box polypeptide 34
    Hs.151706  [show with all ESTs]
    Unigene Representative Sequence: NM_014681
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328771(uc010xyn.2 uc010elc.1 uc010xyo.1) ENST00000471451
    ENST00000486327 ENST00000460681
    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DHX34
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    GenScript: all cDNA clones in your preferred vector: DHX34 (NM_014681)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX34
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      QuantiTect SYBR Green Assays in human, mouse, rat DHX34
      QuantiFast Probe-based Assays in human, mouse, rat DHX34

    Additional mRNA sequence: 

    AK297692.1 AK304710.1 BC035243.1 BC131800.1 

    11 DOTS entries:

    DT.415547  DT.97861838  DT.95136472  DT.101983357  DT.95073840  DT.92428633  DT.100682534  DT.121504156 
    DT.415548  DT.65288301  DT.92428635 

    Selected AceView cDNA sequences (see all 181):

    BQ939671 BE677798 AI949021 CF125167 AI571106 NM_014681 CF125570 BF434827 
    BQ708034 CN478682 NM_194428 BQ643547 BM804906 BM472211 BX328271 BI912411 
    AW502081 CO249674 BG248535 CF125648 BX395215 BI908980 BE910532 BM454335 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DHX34 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21 ^ 22 ^ 23
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for DHX34

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DHX34 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGATAAAAA
    DHX34 Expression
    About this image


    DHX34 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    DHX34 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DHX34 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.151706
        Custom PCR Arrays for DHX34
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX34

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DHX34 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dhx341 , 5 DEAH (Asp-Glu-Ala-His) box polypeptide 341, 5 84.87(n)1
    88.24(a)1
      7 (8.76 cM)5
    717231  NM_001285931.11  NP_001272860.11 
     161971475 
    lizard
    (Anolis carolinensis)
    Reptilia DHX346
    DEAH (Asp-Glu-Ala-His) box polypeptide 34
    66(a)
    1 ↔ 1
    LGf(1636753-1662485)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dhx341 DEAH (Asp-Glu-Ala-His) box polypeptide 34 61.54(n)
    63.28(a)
      100158553  NM_001127987.1  NP_001121459.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dhx341 DEAH (Asp-Glu-Ala-His) box polypeptide 34 62.59(n)
    61.75(a)
      555838  NM_001128333.1  NP_001121805.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG325331 CG32533 55.04(n)
    46.09(a)
      32933  NM_167649.1  NP_728244.1 
    worm
    (Caenorhabditis elegans)
    Secernentea smgl-21 smgl-2 48.95(n)
    44.83(a)
      177135  NM_068004.5  NP_500405.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRP26
    RNA-dependent ATPase in the DEAH-box family, requi...
    28(a)
    1 ↔ 1
    XIV(644320-646950) YNR011C


    ENSEMBL Gene Tree for DHX34 (if available)
    TreeFam Gene Tree for DHX34 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DHX34 gene
    6 SIMAP similar genes for DHX34 using alignment to 2 protein entries:     DHX34_HUMAN (see all proteins):
    DKFZp762F2011    DHX15    DHX40    DHX35    DHX16    DHX33

    Find genes that share paralogs with DHX34           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for DHX34
    PGOHUM00000238302


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DHX34 (see all 1145)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1146884101,2
    F--44275064(+) ATTTCC/AATTTG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1996998941,2
    C--44295213(-) CTTCTC/GTCCAG 1 -- int10--------
    rs353975571,2
    C--47850582(+) TGGAT-/TTAT  
            
    TATTT
    1 -- us2k10--------
    rs609136121,2
    C--47850583(+) TATTTATTT/-  
            
    GTTTG
    1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1913432861,2
    --47850600(+) TATTTA/GTTTGT 1 -- us2k10--------
    rs558548711,2
    C--47850604(+) TATTTA/GTTTGT 1 -- us2k10--------
    rs1131205961,2
    C,F--47850618(+) TTTATC/TTGAGA 1 -- us2k12Minor allele frequency- T:0.33CSA 3
    rs1495953841,2
    --47850627(+) GACAGA/GGTTTC 1 -- us2k10--------
    rs1460901281,2
    --47850640(+) CTTGTC/TGCCCA 1 -- us2k10--------
    rs1880002331,2
    --47850834(+) CTGACC/TTCAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DHX34 (47852538 - 47885961 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for DHX34:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912201CNV Loss21882294
    nsv912200CNV Loss21882294
    nsv517901CNV Loss19592680
    nsv516890CNV Loss19592680
    nsv428366CNV Loss18775914
    nsv9738CNV Gain18304495
    nsv521341CNV Gain19592680
    dgv1107e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DHX34
    DNA2.0 Custom Variant and Variant Library Synthesis for DHX34

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 615475    OMIM disorders: --

    3 diseases for DHX34:    
    About MalaCards
    atopic dermatitis    dermatitis    asthma


    Find genes that share disorders with DHX34           About GenesLikeMe


    Export disorders for DHX34 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DHX34 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with DHX34)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2, 3 Nagase T.... Nomura N. (DNA Res. 1995)
    2. A transcript map of the chromosome 19q-Arm glioma tumor suppressor region. (PubMed id 10708517)1, 3 Smith J.S.... Jenkins R.B. (Genomics 2000)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans. (PubMed id 23828042)1 Longman D....CA!ceres J.F. (Nucleic Acids Res. 2013)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 9704 HGNC: 16719 AceView: DHX34 Ensembl:ENSG00000134815 euGenes: HUgn9704
    ECgene: DHX34 H-InvDB: DHX34

    (According to HUGE)
    About This Section

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    HUGE: KIAA0134

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DHX34 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DHX34 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DHX34 gene:
    Search GeneIP for patents involving DHX34

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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