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Aliases for DHX33 Gene

Aliases for DHX33 Gene

  • DEAH-Box Helicase 33 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 33 2 3
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 33 2 3
  • DEAH Box Protein 33 3 4
  • DDX33 3 4
  • Putative ATP-Dependent RNA Helicase DHX33 3
  • EC 4
  • EC 3.6.1 58

External Ids for DHX33 Gene

Previous HGNC Symbols for DHX33 Gene

  • DDX33

Previous GeneCards Identifiers for DHX33 Gene

  • GC17M005292
  • GC17M005546
  • GC17M005286
  • GC17M005236
  • GC17M005360

Summaries for DHX33 Gene

Entrez Gene Summary for DHX33 Gene

  • This gene encodes a member of the DEAD box protein family. The DEAD box proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

GeneCards Summary for DHX33 Gene

DHX33 (DEAH-Box Helicase 33) is a Protein Coding gene. Among its related pathways are Toll-Like receptor Signaling Pathways. GO annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DHX35.

UniProtKB/Swiss-Prot for DHX33 Gene

  • Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. Important element of nucleolar organization.

Additional gene information for DHX33 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX33 Gene

Genomics for DHX33 Gene

Regulatory Elements for DHX33 Gene

Enhancers for DHX33 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H005110 1.1 ENCODE 21 +357.1 357087 2.1 HDGF MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ANKFY1 LOC101928000 LOC100130950 RPAIN DHX33 ZNF232 DERL2 ENSG00000263272 ZNF594 ENSG00000263220
GH17H004553 1.1 ENCODE 20.9 +914.0 913985 2.6 HDGF ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZNF207 SP3 SP5 MYBBP1A RPAIN ANKFY1 LOC100130950 DHX33 ZNF232 LOC101927979 GGT6 ENSG00000263220 ZNF594
GH17H005416 1.6 Ensembl ENCODE dbSUPER 10.8 +50.1 50110 4.7 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1 ZNF302 ZNF143 RABEP1 RPAIN ZNF594 ENSG00000263272 ENSG00000263220 C1QBP DHX33 PELP1 LOC101927979 DERL2
GH17H005240 1.3 Ensembl ENCODE dbSUPER 11.7 +226.7 226705 2.9 HDGF TBL1XR1 RB1 SIN3A BMI1 PLRG1 YBX1 ZNF143 ZNF207 ATF7 ANKFY1 LOC101928000 DHX33 RPAIN LOC101927979 ENSG00000263164 USP6 CAMTA2 GC17M005239
GH17H005525 1.4 FANTOM5 Ensembl ENCODE 10.7 -58.0 -57987 3.2 PKNOX1 ATF1 INSM2 KLF17 FEZF1 GLI4 RFX5 ZNF366 FOS ZNF391 NLRP1 RPAIN DERL2 MIS12 DHX33 RNU7-31P LOC105371507
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DHX33 on UCSC Golden Path with GeneCards custom track

Promoters for DHX33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000090626 560 2200 HDGF MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Locations for DHX33 Gene

Genomic Locations for DHX33 Gene
28,149 bases
Minus strand

Genomic View for DHX33 Gene

Genes around DHX33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX33 Gene

Proteins for DHX33 Gene

  • Protein details for DHX33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative ATP-dependent RNA helicase DHX33
    Protein Accession:
    Secondary Accessions:
    • B4DHF9
    • Q4G149
    • Q5CZ73
    • Q9H5M9

    Protein attributes for DHX33 Gene

    707 amino acids
    Molecular mass:
    78874 Da
    Quaternary structure:
    • Interacts with UBTF.
    • Sequence=AAH30017.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DHX33 Gene


neXtProt entry for DHX33 Gene

Selected DME Specific Peptides for DHX33 Gene


Post-translational modifications for DHX33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHX33 Gene

Domains & Families for DHX33 Gene

Gene Families for DHX33 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DHX33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DEAD box helicase family. DEAH subfamily.
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX33: view

Function for DHX33 Gene

Molecular function for DHX33 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. Important element of nucleolar organization.

Enzyme Numbers (IUBMB) for DHX33 Gene

Phenotypes From GWAS Catalog for DHX33 Gene

Gene Ontology (GO) - Molecular Function for DHX33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000182 rDNA binding IEA,IDA 21930779
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA,IDA 22658674
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
genes like me logo Genes that share ontologies with DHX33: view
genes like me logo Genes that share phenotypes with DHX33: view

Animal Models for DHX33 Gene

MGI Knock Outs for DHX33:

Animal Model Products

CRISPR Products

miRNA for DHX33 Gene

miRTarBase miRNAs that target DHX33

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DHX33 Gene

Localization for DHX33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX33 Gene

Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Predominantly in the nucleolus. During mitosis, localizes with the nucleolar organizing regions.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHX33 gene
Compartment Confidence
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DHX33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IEA,IDA 21930779
GO:0005730 nucleolus IDA 21930779
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DHX33: view

Pathways & Interactions for DHX33 Gene

genes like me logo Genes that share pathways with DHX33: view

Pathways by source for DHX33 Gene

1 KEGG pathway for DHX33 Gene

Gene Ontology (GO) - Biological Process for DHX33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IBA --
GO:0045943 positive regulation of transcription from RNA polymerase I promoter IEA,IDA 21930779
genes like me logo Genes that share ontologies with DHX33: view

No data available for SIGNOR curated interactions for DHX33 Gene

Drugs & Compounds for DHX33 Gene

(3) Drugs for DHX33 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Nutra Agonist 0

(1) Additional Compounds for DHX33 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DHX33: view

Transcripts for DHX33 Gene

Unigene Clusters for DHX33 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 33:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX33 Gene

No ASD Table

Relevant External Links for DHX33 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHX33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHX33 Gene

Protein differential expression in normal tissues from HIPED for DHX33 Gene

This gene is overexpressed in Plasma (67.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DHX33 Gene

Protein tissue co-expression partners for DHX33 Gene

NURSA nuclear receptor signaling pathways regulating expression of DHX33 Gene:


SOURCE GeneReport for Unigene cluster for DHX33 Gene:


Evidence on tissue expression from TISSUES for DHX33 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with DHX33: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHX33 Gene

Orthologs for DHX33 Gene

This gene was present in the common ancestor of animals.

Orthologs for DHX33 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DHX33 33 34
  • 99.48 (n)
(Bos Taurus)
Mammalia DHX33 34
  • 91 (a)
(Rattus norvegicus)
Mammalia Dhx33 33
  • 90.59 (n)
(Mus musculus)
Mammalia Dhx33 33 16 34
  • 90.26 (n)
(Canis familiaris)
Mammalia DHX33 33 34
  • 85.97 (n)
(Monodelphis domestica)
Mammalia DHX33 34
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 72 (a)
-- 34
  • 72 (a)
(Gallus gallus)
Aves DHX33 33
  • 79.18 (n)
(Anolis carolinensis)
Reptilia DHX33 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx33 33
  • 74.08 (n)
Str.4876 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6757 33
(Danio rerio)
Actinopterygii DHX33 34
  • 73 (a)
LOC796505 33
  • 69.51 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006138 33
  • 54.46 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4901 33 34
  • 51.79 (n)
(Caenorhabditis elegans)
Secernentea T05E8.3 34
  • 30 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2140 33
Species where no ortholog for DHX33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHX33 Gene

Gene Tree for DHX33 (if available)
Gene Tree for DHX33 (if available)

Paralogs for DHX33 Gene

Paralogs for DHX33 Gene

(11) SIMAP similar genes for DHX33 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DHX33: view

Variants for DHX33 Gene

Sequence variations from dbSNP and Humsavar for DHX33 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000230318 -- 5,444,585(+) GTGTT(A/G)GGGCA intron-variant
rs1000334367 -- 5,445,886(+) AGATA(C/T)CTTTC intron-variant
rs1000342569 -- 5,450,770(+) TGTAA(C/T)GTACA intron-variant
rs1000343103 -- 5,462,694(+) CTGCT(-/GAGA)GAGAC intron-variant, upstream-variant-2KB
rs1000450321 -- 5,446,128(+) CACCA(C/T)CACGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHX33 Gene

Variant ID Type Subtype PubMed ID
nsv574273 CNV gain 21841781
nsv1134590 CNV deletion 24896259

Variation tolerance for DHX33 Gene

Residual Variation Intolerance Score: 62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.49; 85.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHX33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX33 Gene

Disorders for DHX33 Gene

Relevant External Links for DHX33

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DHX33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX33 Gene

Publications for DHX33 Gene

  1. Identification of DHX33 as a mediator of rRNA synthesis and cell growth. (PMID: 21930779) Zhang Y … Weber JD (Molecular and cellular biology 2011) 3 4 60
  2. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 45 60
  3. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 45 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for DHX33 Gene

Sources for DHX33 Gene

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