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Aliases for DHX33 Gene

Aliases for DHX33 Gene

  • DEAH-Box Helicase 33 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 33 2 3
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 33 2 3
  • DEAH Box Protein 33 3 4
  • DDX33 3 4
  • Putative ATP-Dependent RNA Helicase DHX33 3
  • EC 4
  • EC 3.6.1 56

External Ids for DHX33 Gene

Previous HGNC Symbols for DHX33 Gene

  • DDX33

Previous GeneCards Identifiers for DHX33 Gene

  • GC17M005292
  • GC17M005546
  • GC17M005286
  • GC17M005236
  • GC17M005360

Summaries for DHX33 Gene

Entrez Gene Summary for DHX33 Gene

  • This gene encodes a member of the DEAD box protein family. The DEAD box proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

GeneCards Summary for DHX33 Gene

DHX33 (DEAH-Box Helicase 33) is a Protein Coding gene. Among its related pathways are Toll-like receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DHX8.

UniProtKB/Swiss-Prot for DHX33 Gene

  • Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. Important element of nucleolar organization.

Additional gene information for DHX33 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX33 Gene

Genomics for DHX33 Gene

GeneHancer (GH) Regulatory Elements for DHX33 Gene

Promoters and enhancers for DHX33 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I005466 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 561.8 +0.8 837 3 HDGF CLOCK MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 DHX33 LOC105371506 RPAIN NUP88 DERL2 ZNF594 RABEP1 MIS12 LOC100130950 PELP1
GH17I004965 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 19.2 +500.4 500444 5.4 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 SPAG7 PIR49988 MIR6864 MIR6865 ENSG00000262429 ZNF232 NUP88 MIS12 INCA1 CHRNE
GH17I004553 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 20.9 +914.0 913984 2.6 HDGF SMAD1 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF213 ZNF207 MYBBP1A RPAIN ANKFY1 LOC100130950 DHX33 ZNF232 LOC101927979 GGT6 ENSG00000263220 ZNF594
GH17I005110 Promoter/Enhancer 1.6 Ensembl ENCODE 21 +357.1 357086 2.1 HDGF MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 LOC101928000 ANKFY1 LOC100130950 RPAIN DHX33 ZNF232 DERL2 ENSG00000263272 ZNF594 ENSG00000263220
GH17I005416 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10.8 +50.1 50109 4.7 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B IRF4 YY1 RPAIN NUP88 RABEP1 ZNF594 ENSG00000263272 ENSG00000263220 C1QBP DHX33 PELP1 LOC101927979
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DHX33 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DHX33 gene promoter:

Genomic Locations for DHX33 Gene

Genomic Locations for DHX33 Gene
28,149 bases
Minus strand

Genomic View for DHX33 Gene

Genes around DHX33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX33 Gene

Proteins for DHX33 Gene

  • Protein details for DHX33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative ATP-dependent RNA helicase DHX33
    Protein Accession:
    Secondary Accessions:
    • B4DHF9
    • Q4G149
    • Q5CZ73
    • Q9H5M9

    Protein attributes for DHX33 Gene

    707 amino acids
    Molecular mass:
    78874 Da
    Quaternary structure:
    • Interacts with UBTF.
    • Sequence=AAH30017.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DHX33 Gene


neXtProt entry for DHX33 Gene

Selected DME Specific Peptides for DHX33 Gene


Post-translational modifications for DHX33 Gene

No Post-translational modifications

Other Protein References for DHX33 Gene

Domains & Families for DHX33 Gene

Gene Families for DHX33 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DHX33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DEAD box helicase family. DEAH subfamily.
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX33: view

Function for DHX33 Gene

Molecular function for DHX33 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. Important element of nucleolar organization.

Enzyme Numbers (IUBMB) for DHX33 Gene

Phenotypes From GWAS Catalog for DHX33 Gene

Gene Ontology (GO) - Molecular Function for DHX33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000182 rDNA binding IEA,IDA 21930779
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
genes like me logo Genes that share ontologies with DHX33: view
genes like me logo Genes that share phenotypes with DHX33: view

Animal Models for DHX33 Gene

MGI Knock Outs for DHX33:

Animal Model Products

CRISPR Products

miRNA for DHX33 Gene

miRTarBase miRNAs that target DHX33

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DHX33 Gene

Localization for DHX33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX33 Gene

Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Predominantly in the nucleolus. During mitosis, localizes with the nucleolar organizing regions.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHX33 gene
Compartment Confidence
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DHX33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA,IEA 21930779
GO:0005730 nucleolus IDA 21930779
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DHX33: view

Pathways & Interactions for DHX33 Gene

genes like me logo Genes that share pathways with DHX33: view

Pathways by source for DHX33 Gene

1 KEGG pathway for DHX33 Gene

Gene Ontology (GO) - Biological Process for DHX33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IBA --
GO:0045943 positive regulation of transcription by RNA polymerase I IDA,IEA 21930779
genes like me logo Genes that share ontologies with DHX33: view

No data available for SIGNOR curated interactions for DHX33 Gene

Drugs & Compounds for DHX33 Gene

(3) Drugs for DHX33 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for DHX33 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DHX33: view

Transcripts for DHX33 Gene

Unigene Clusters for DHX33 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 33:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX33 Gene

No ASD Table

Relevant External Links for DHX33 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHX33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHX33 Gene

Protein differential expression in normal tissues from HIPED for DHX33 Gene

This gene is overexpressed in Plasma (67.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DHX33 Gene

Protein tissue co-expression partners for DHX33 Gene

NURSA nuclear receptor signaling pathways regulating expression of DHX33 Gene:


SOURCE GeneReport for Unigene cluster for DHX33 Gene:


Evidence on tissue expression from TISSUES for DHX33 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with DHX33: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHX33 Gene

Orthologs for DHX33 Gene

This gene was present in the common ancestor of animals.

Orthologs for DHX33 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DHX33 33 34
  • 99.48 (n)
(Bos Taurus)
Mammalia DHX33 34
  • 91 (a)
(Rattus norvegicus)
Mammalia Dhx33 33
  • 90.59 (n)
(Mus musculus)
Mammalia Dhx33 33 16 34
  • 90.26 (n)
(Canis familiaris)
Mammalia DHX33 33 34
  • 85.97 (n)
(Monodelphis domestica)
Mammalia DHX33 34
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 72 (a)
-- 34
  • 72 (a)
(Gallus gallus)
Aves DHX33 33
  • 79.18 (n)
(Anolis carolinensis)
Reptilia DHX33 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx33 33
  • 74.08 (n)
Str.4876 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6757 33
(Danio rerio)
Actinopterygii DHX33 34
  • 73 (a)
LOC796505 33
  • 69.51 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006138 33
  • 54.46 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4901 33 34
  • 51.79 (n)
(Caenorhabditis elegans)
Secernentea T05E8.3 34
  • 30 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2140 33
Species where no ortholog for DHX33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHX33 Gene

Gene Tree for DHX33 (if available)
Gene Tree for DHX33 (if available)

Paralogs for DHX33 Gene

Paralogs for DHX33 Gene

(11) SIMAP similar genes for DHX33 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DHX33: view

Variants for DHX33 Gene

Sequence variations from dbSNP and Humsavar for DHX33 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000230318 -- 5,444,585(-) G/A intron_variant
rs1000334367 -- 5,445,886(-) C/T intron_variant
rs1000342569 -- 5,450,770(-) T/C intron_variant
rs1000343103 -- 5,462,694(-) GAGAGAGA/GAGA genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000450321 -- 5,446,128(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DHX33 Gene

Variant ID Type Subtype PubMed ID
nsv1134590 CNV deletion 24896259
nsv574273 CNV gain 21841781

Variation tolerance for DHX33 Gene

Residual Variation Intolerance Score: 62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.49; 85.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DHX33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX33 Gene

Disorders for DHX33 Gene

Additional Disease Information for DHX33

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DHX33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX33 Gene

Publications for DHX33 Gene

  1. Identification of DHX33 as a mediator of rRNA synthesis and cell growth. (PMID: 21930779) Zhang Y … Weber JD (Molecular and cellular biology 2011) 3 4 58
  2. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58
  3. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for DHX33 Gene

Sources for DHX33 Gene

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