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Aliases for DHX33 Gene

Aliases for DHX33 Gene

  • DEAH-Box Helicase 33 2 3
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 33 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 33 2 3
  • DEAH Box Protein 33 3 4
  • DDX33 3 4
  • EC 3.6.4.13 4
  • EC 3.6.1 63

External Ids for DHX33 Gene

Previous HGNC Symbols for DHX33 Gene

  • DDX33

Previous GeneCards Identifiers for DHX33 Gene

  • GC17M005292
  • GC17M005546
  • GC17M005286
  • GC17M005236
  • GC17M005360

Summaries for DHX33 Gene

Entrez Gene Summary for DHX33 Gene

  • This gene encodes a member of the DEAD box protein family. The DEAD box proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

GeneCards Summary for DHX33 Gene

DHX33 (DEAH-Box Helicase 33) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DHX16.

UniProtKB/Swiss-Prot for DHX33 Gene

  • Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. Important element of nucleolar organization.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX33 Gene

Genomics for DHX33 Gene

Regulatory Elements for DHX33 Gene

Enhancers for DHX33 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DHX33 on UCSC Golden Path with GeneCards custom track

Promoters for DHX33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DHX33 on UCSC Golden Path with GeneCards custom track

Genomic Location for DHX33 Gene

Chromosome:
17
Start:
5,440,912 bp from pter
End:
5,469,060 bp from pter
Size:
28,149 bases
Orientation:
Minus strand

Genomic View for DHX33 Gene

Genes around DHX33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX33 Gene

Proteins for DHX33 Gene

  • Protein details for DHX33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6R0-DHX33_HUMAN
    Recommended name:
    Putative ATP-dependent RNA helicase DHX33
    Protein Accession:
    Q9H6R0
    Secondary Accessions:
    • B4DHF9
    • Q4G149
    • Q5CZ73
    • Q9H5M9

    Protein attributes for DHX33 Gene

    Size:
    707 amino acids
    Molecular mass:
    78874 Da
    Quaternary structure:
    • Interacts with UBTF.
    SequenceCaution:
    • Sequence=AAH30017.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DHX33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHX33 Gene

Proteomics data for DHX33 Gene at MOPED

Selected DME Specific Peptides for DHX33 Gene

Post-translational modifications for DHX33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHX33 Gene

Domains & Families for DHX33 Gene

Gene Families for DHX33 Gene

Suggested Antigen Peptide Sequences for DHX33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H6R0

UniProtKB/Swiss-Prot:

DHX33_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DEAH subfamily.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX33: view

Function for DHX33 Gene

Molecular function for DHX33 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. Important element of nucleolar organization.

Enzyme Numbers (IUBMB) for DHX33 Gene

Gene Ontology (GO) - Molecular Function for DHX33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000182 rDNA binding IDA 21930779
GO:0003676 nucleic acid binding IEA --
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding IEA --
GO:0008026 ATP-dependent helicase activity IEA --
genes like me logo Genes that share ontologies with DHX33: view
genes like me logo Genes that share phenotypes with DHX33: view

Animal Models for DHX33 Gene

MGI Knock Outs for DHX33:

Animal Model Products

miRNA for DHX33 Gene

miRTarBase miRNAs that target DHX33

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DHX33 Gene

Localization for DHX33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX33 Gene

Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Predominantly in the nucleolus. During mitosis, localizes with the nucleolar organizing regions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHX33 Gene COMPARTMENTS Subcellular localization image for DHX33 gene
Compartment Confidence
nucleus 5
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for DHX33 Gene

Pathways & Interactions for DHX33 Gene

SuperPathways for DHX33 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHX33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with DHX33: view

No data available for Pathways by source and SIGNOR curated interactions for DHX33 Gene

Drugs & Compounds for DHX33 Gene

(1) Drugs for DHX33 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DHX33 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DHX33: view

Transcripts for DHX33 Gene

Unigene Clusters for DHX33 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 33:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHX33 Gene

No ASD Table

Relevant External Links for DHX33 Gene

GeneLoc Exon Structure for
DHX33
ECgene alternative splicing isoforms for
DHX33

Expression for DHX33 Gene

mRNA expression in normal human tissues for DHX33 Gene

Protein differential expression in normal tissues from HIPED for DHX33 Gene

This gene is overexpressed in Plasma (67.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHX33 Gene



SOURCE GeneReport for Unigene cluster for DHX33 Gene Hs.250456

genes like me logo Genes that share expression patterns with DHX33: view

Protein tissue co-expression partners for DHX33 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DHX33 Gene

Orthologs for DHX33 Gene

This gene was present in the common ancestor of animals.

Orthologs for DHX33 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia DHX33 35
  • 85.97 (n)
  • 90.86 (a)
DHX33 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dhx33 35
  • 90.26 (n)
  • 93.55 (a)
Dhx33 16
Dhx33 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DHX33 35
  • 99.48 (n)
  • 99.58 (a)
DHX33 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dhx33 35
  • 90.59 (n)
  • 94.41 (a)
cow
(Bos Taurus)
Mammalia DHX33 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DHX33 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 72 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
chicken
(Gallus gallus)
Aves DHX33 35
  • 79.18 (n)
  • 86.14 (a)
lizard
(Anolis carolinensis)
Reptilia DHX33 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx33 35
  • 74.08 (n)
  • 80 (a)
Str.4876 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6757 35
zebrafish
(Danio rerio)
Actinopterygii LOC796505 35
  • 69.51 (n)
  • 73.53 (a)
DHX33 36
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006138 35
  • 54.46 (n)
  • 48.25 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4901 35
  • 51.79 (n)
  • 46.49 (a)
CG4901 36
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T05E8.3 36
  • 30 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2140 35
Species with no ortholog for DHX33:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHX33 Gene

ENSEMBL:
Gene Tree for DHX33 (if available)
TreeFam:
Gene Tree for DHX33 (if available)

Paralogs for DHX33 Gene

Paralogs for DHX33 Gene

(11) SIMAP similar genes for DHX33 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DHX33: view

Variants for DHX33 Gene

Sequence variations from dbSNP and Humsavar for DHX33 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs8069315 - 5,463,627(+) CTGGC(A/G)GCTGA intron-variant, nc-transcript-variant, reference, missense
rs11653658 - 5,450,884(+) CTTAT(C/G)TTCAA intron-variant, reference, missense
rs1805439 -- 5,465,424(+) CAGGG(A/C)AACAG intron-variant
rs1805440 -- 5,465,909(+) AGTGC(A/G)CCATC intron-variant
rs1476561 -- 5,449,199(+) AAAAA(C/T)ATGAA intron-variant

Variation tolerance for DHX33 Gene

Residual Variation Intolerance Score: 62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.49; 85.84% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for DHX33 Gene

Disorders for DHX33 Gene

Relevant External Links for DHX33

Genetic Association Database (GAD)
DHX33
Human Genome Epidemiology (HuGE) Navigator
DHX33
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHX33

No disorders were found for DHX33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX33 Gene

Publications for DHX33 Gene

  1. Identification of DHX33 as a mediator of rRNA synthesis and cell growth. (PMID: 21930779) Zhang Y. … Weber J.D. (Mol. Cell. Biol. 2011) 3 4 67
  2. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  3. The DHX33 RNA Helicase Promotes mRNA Translation Initiation. (PMID: 26100019) Zhang Y. … Weber J. (Mol. Cell. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for DHX33 Gene

Sources for DHX33 Gene

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