Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DHX33 Gene

protein-coding   GIFtS: 49
GCID: GC17M005360

DEAH (Asp-Glu-Ala-His) Box Polypeptide 33

(Previous name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 33)
(Previous symbol: DDX33)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
DEAH (Asp-Glu-Ala-His) Box Polypeptide 331 2     Putative ATP-Dependent RNA Helicase DHX332
DDX331 2 3     EC 3.6.4.133
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 331 2     EC 3.6.18
DEAH Box Protein 332 3     

External Ids:    HGNC: 167181   Entrez Gene: 569192   Ensembl: ENSG000000051007   OMIM: 6144055   UniProtKB: Q9H6R03   

Export aliases for DHX33 gene to outside databases

Previous GC identifers: GC17M005292 GC17M005546 GC17M005286 GC17M005236


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DHX33 Gene:
This gene encodes a member of the DEAD box protein family. The DEAD box proteins are characterized by the
conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular
processes involving alteration of RNA secondary structure such as translation initiation, nuclear and
mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members
of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular
growth and division. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Dec 2010)

GeneCards Summary for DHX33 Gene:
DHX33 (DEAH (Asp-Glu-Ala-His) box polypeptide 33) is a protein-coding gene. GO annotations related to this gene include rDNA binding and ATP-dependent helicase activity. An important paralog of this gene is DHX16.

UniProtKB/Swiss-Prot: DHX33_HUMAN, Q9H6R0
Function: Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA
(rDNA) loci where it is involved in POLR1A recruitment. Important element of nucleolar organization




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DHX33 gene promoter:
         p53   HNF-3beta   SREBP-1b   Evi-1   CREB   POU2F1   SREBP-1a   HSF2   deltaCREB   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDHX33 promoter sequence
   Search Chromatin IP Primers for DHX33

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DHX33


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.2   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13

DHX33 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHX33 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M005360:  view genomic region     (about GC identifiers)

Start:
5,344,232 bp from pter      End:
5,372,380 bp from pter
Size:
28,149 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DHX33_HUMAN, Q9H6R0 (See protein sequence)
Recommended Name: Putative ATP-dependent RNA helicase DHX33  
Size: 707 amino acids; 78874 Da
Subunit: Interacts with UBTF
Sequence caution: Sequence=AAH30017.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B4DHF9 Q4G149 Q5CZ73 Q9H5M9
Alternative splicing: 2 isoforms:  Q9H6R0-1   Q9H6R0-2   

Explore the universe of human proteins at neXtProt for DHX33: NX_Q9H6R0

Explore proteomics data for DHX33 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DHX33 (Q9H6R0) (see all 11)
     TNIAETS  CYRLYTE  FLTGQEE  AETSITI 


    See DHX33 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186628.1  NP_064547.2  

    ENSEMBL proteins: 
     ENSP00000225296   ENSP00000413779   ENSP00000458925   ENSP00000458203  

    DHX33 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for DHX33
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DHX33
    GenScript Custom Purified and Recombinant Proteins Services for DHX33
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for DHX33 

     
    antibodies-online proteins for DHX33 (2 products) 

     
    Search antibodies-online for peptides for DHX33

    DHX33 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DHX33
    Novus Biologicals DHX33 Antibodies
    Abcam antibodies for DHX33
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for DHX33
    antibodies-online antibodies for DHX33 (5 products) 

    DHX33 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DHX33
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DHX33
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for DHX33 
    antibodies-online kits for DHX33 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    DHX: DEAH-boxes

    Selected InterPro protein domains (see all 7):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR002464 DNA/RNA_helicase_DEAH_CS
     IPR007502 Helicase-assoc_dom
     IPR011709 DUF1605
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9H6R0

    ProtoNet protein and cluster: Q9H6R0

    2 Blocks protein domains:
    IPB002464 ATP-dependent helicase
    IPB007502 Helicase-associated region


    UniProtKB/Swiss-Prot: DHX33_HUMAN, Q9H6R0
    Similarity: Belongs to the DEAD box helicase family. DEAH subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Find genes that share domains with DHX33           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DHX33_HUMAN, Q9H6R0
    Function: Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA
    (rDNA) loci where it is involved in POLR1A recruitment. Important element of nucleolar organization
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000182rDNA binding IDA--
    GO:0003676nucleic acid binding ----
    GO:0004386helicase activity ----
    GO:0005524ATP binding IEA--
    GO:0008026ATP-dependent helicase activity IEA--
         
    Find genes that share ontologies with DHX33           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DHX33:
     Decreased p24 protein expressi 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DHX33

    miRNA
    Products:
        
    miRTarBase miRNAs that target DHX33:
    hsa-let-7b-5p (MIRT032227), hsa-mir-17-5p (MIRT050797), hsa-mir-23b-3p (MIRT046349), hsa-mir-124-3p (MIRT022175), hsa-mir-30a-5p (MIRT028394)

    Block miRNA regulation of human, mouse, rat DHX33 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DHX33 (see all 25):
    hsa-miR-485-5p hsa-miR-125a-5p hsa-miR-429 hsa-miR-373* hsa-miR-1184 hsa-miR-125b hsa-miR-320e hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmidDHX33 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DHX33
    Predesigned siRNA for gene silencing in human, mouse, rat DHX33

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DHX33

    Clone
    Products:
         
    OriGene clones in human, mouse for DHX33 (see all 6)
    OriGene ORF clones in mouse, rat for DHX33
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DHX33 (NM_020162)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHX33
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX33

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DHX33
    Browse ESI BIO Cell Lines and PureStem Progenitors for DHX33 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX33


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DHX33_HUMAN, Q9H6R0: Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Predominantly in the nucleolus. During
    mitosis, localizes with the nucleolar organizing regions
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm IDA--
    GO:0005730nucleolus IDA--

    Find genes that share ontologies with DHX33           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DHX33
    Interactions:

        Search GeneGlobe Interaction Network for DHX33

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DHX33 (Q9H6R03 ENSP000002252964) via UniProtKB, MINT, STRING, and/or I2D (see all 105)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TERF2Q155543, ENSP000002549424I2D: score=1 STRING: ENSP00000254942
    USP36Q9P2753, ENSP000003105904I2D: score=2 STRING: ENSP00000310590
    NOL6ENSP000002979904STRING: ENSP00000297990
    NOP9ENSP000002674254STRING: ENSP00000267425
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045943positive regulation of transcription from RNA polymerase I promoter IDA--

    Find genes that share ontologies with DHX33           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DHX33



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DHX33 gene (2 alternative transcripts): 
    NM_001199699.1  NM_020162.3  

    Unigene Cluster for DHX33:

    DEAH (Asp-Glu-Ala-His) box polypeptide 33
    Hs.250456  [show with all ESTs]
    Unigene Representative Sequence: NM_020162
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000225296(uc002gbz.3 uc002gca.3 uc002gcb.3 uc010clf.3)
    ENST00000575153 ENST00000433302 ENST00000572490 ENST00000574023
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DHX33 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DHX33 (see all 25):
    hsa-miR-485-5p hsa-miR-125a-5p hsa-miR-429 hsa-miR-373* hsa-miR-1184 hsa-miR-125b hsa-miR-320e hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmidDHX33 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DHX33
    Predesigned siRNA for gene silencing in human, mouse, rat DHX33
    Clone
    Products:
         
    OriGene clones in human, mouse for DHX33 (see all 6)
    OriGene ORF clones in mouse, rat for DHX33
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DHX33 (NM_020162)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHX33
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX33
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DHX33
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DHX33
      QuantiTect SYBR Green Assays in human, mouse, rat DHX33
      QuantiFast Probe-based Assays in human, mouse, rat DHX33

    Additional mRNA sequence: 

    AK025625.1 AK026944.1 AK295074.1 AK295760.1 AK314580.1 AL359945.1 BC030017.1 BC042040.1 
    BC050409.1 CR936655.1 

    9 DOTS entries:

    DT.92418673  DT.95369719  DT.97779254  DT.100690973  DT.444986  DT.95369718  DT.100019809  DT.120977783 
    DT.102837310 

    Selected AceView cDNA sequences (see all 690):

    CR590289 BI856893 AA195196 AI266742 AI360839 BM470043 CA423853 BU182217 
    BE783135 BU179057 BU848729 BI858364 BU158044 BM553596 CR604243 BF220000 
    BU167665 BU517260 CR608216 AA368335 BQ054524 BM551998 AA954623 BM712283 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DHX33 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGCTCTCT
    DHX33 Expression
    About this image

    DHX33 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DHX33 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.250456
        Custom PCR Arrays for DHX33
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for DHX33
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DHX33
    QuantiTect SYBR Green Assays in human, mouse, rat DHX33
    QuantiFast Probe-based Assays in human, mouse, rat DHX33
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX33

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for DHX33 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dhx331 , 5 DEAH (Asp-Glu-Ala-His) box polypeptide 331, 5 90.26(n)1
    93.55(a)1
      11 (43.21 cM)5
    2168771  NM_178367.41  NP_848144.31 
     709840915 
    chicken
    (Gallus gallus)
    Aves DHX331 DEAH (Asp-Glu-Ala-His) box polypeptide 33 79.18(n)
    86.14(a)
      417499  XM_004946459.1  XP_004946516.1 
    lizard
    (Anolis carolinensis)
    Reptilia DHX336
    DEAH (Asp-Glu-Ala-His) box polypeptide 33
    76(a)
    1 ↔ 1
    GL343393.1(333480-535130)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.67572 Xenopus laevis transcribed sequence with weak similarity more 75.99(n)    BJ066947.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7965051 putative ATP-dependent RNA helicase DHX33-like 69.51(n)
    73.53(a)
      796505  NM_001100057.2  NP_001093527.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG49011 CG4901 51.79(n)
    46.49(a)
      34357  NM_135512.3  NP_609356.2 
    worm
    (Caenorhabditis elegans)
    Secernentea T05E8.36
    Protein T05E8.3 (T05E8.3) mRNA, complete cds
    30(a)
    1 ↔ 1
    I(5472321-5479438) WBGene00020263


    ENSEMBL Gene Tree for DHX33 (if available)
    TreeFam Gene Tree for DHX33 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DHX33 gene
    DHX162  DHX352  DHX152  DQX12  DHX322  DHX82  
    11 SIMAP similar genes for DHX33 using alignment to 4 protein entries:     DHX33_HUMAN (see all proteins):
    DKFZp762F2011    DHX8    DHX16    DHX35    DHX38    DHX15
    DHX32    DHX36    DHX34    DHX40    DQX1

    Find genes that share paralogs with DHX33           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DHX33 (see all 681)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1425690541,2
    C--5344476(+) TTCCA-/GGCA  
      GTTCCT
    GGTAG
    2 -- ut310--------
    rs717262151,2
    C--5344478(+) CCAGG-/CAGT  
      TCCTGG
    TAGCT
    2 -- ut310--------
    rs786639111,2
    C--5344485(+) GTTCCA/TGGTAG 2 -- ut311Minor allele frequency- T:0.00CSA 1
    rs1844763221,2
    C--5344640(+) CCTGCA/C/TCCTTG 4 -- ut310--------
    rs1384391981,2
    C--5344824(+) AATGG-/AAAAGA 2 -- ut310--------
    rs1121285491,2
    C,F--5344832(+) AGAGAG/ATAGCT 2 -- ut312Minor allele frequency- A:0.04NA 122
    rs1117297361,2
    C,F--5344898(+) TACTAT/ACTCCT 2 -- ut311Minor allele frequency- A:0.50NA 2
    rs1404598521,2
    --5344915(+) CAATAG/TAAACA 2 -- ut310--------
    rs1503716451,2
    --5345002(+) TAAAAA/GTTAAC 2 -- ut310--------
    rs1450529411,2
    --5345013(+) TTTTTA/TAAAAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for DHX33 (5344232 - 5372380 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DHX33: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DHX33
    DNA2.0 Custom Variant and Variant Library Synthesis for DHX33

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 614405    OMIM disorders: --


    Find genes that share disorders with DHX33           About GenesLikeMe

    Genetic Association Database (GAD): DHX33
    Human Genome Epidemiology (HuGE) Navigator: DHX33 (5 documents)

    Export disorders for DHX33 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DHX33 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with DHX33)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of DHX33 as a mediator of rRNA synthesis and cell growth. (PubMed id 21930779)1, 2 Zhang Y.... Weber J.D. (Mol. Cell. Biol. 2011)
    2. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    3. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Identification of UHRF1/2 as new N-methylpurine DNA glycosylase-interacting proteins. (PubMed id 23537643)1 Liang C....Zhang L. (Biochem. Biophys. Res. Commun. 2013)
    7. P19ARF and RasVA^A^ offer opposing regulation of DHX33 translation to dictate tumor cell fate. (PubMed id 23401854)1 Zhang Y....Weber J.D. (Mol. Cell. Biol. 2013)
    8. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    9. The DHX33 RNA helicase senses cytosolic RNA and activates the NLRP3 inflammasome. (PubMed id 23871209)1 Mitoma H....Liu Y.J. (Immunity 2013)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 56919 HGNC: 16718 AceView: C1QBPandDHX33 Ensembl:ENSG00000005100 euGenes: HUgn56919
    ECgene: DHX33 H-InvDB: DHX33

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DHX33 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DHX33 gene:
    Search GeneIP for patents involving DHX33

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DHX33  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for DHX33  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DHX33  
     OriGene qSTAR qPCR primer pairs in human, mouse for DHX33   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for DHX33   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DHX33   OriGene Custom Protein Services for DHX33  

     
     
     Block miRNA regulation of human, mouse, rat DHX33 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DHX33
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DHX33 Predesigned siRNA for gene silencing in human, mouse, rat DHX33
     QuantiFast Probe-based Assays in human, mouse, rat DHX33 QuantiTect SYBR Green Assays in human, mouse, rat DHX33
     Custom PCR Arrays for DHX33 Search Chromatin IP Primers for DHX33
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DHX33  Search GeneGlobe Interaction Network for DHX33
     Regulatory tfbs in DHX33 promoter
     GenScript Custom Purified and Recombinant Proteins Services for DHX33 GenScript cDNA clones with any tag delivered in your preferred vector for DHX33
     GenScript Custom Assay Services for DHX33 GenScript Custom overexpressing Cell Line Services for DHX33
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DHX33
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DHX33 antibodies
     Antibodies for DHX33
     See all of Abcam's Antibodies, Kits and Proteins for DHX33
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for DHX33
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX33
     SwitchGear 3'UTR luciferase reporter plasmids for DHX33
     SwitchGear Promoter luciferase reporter plasmids for DHX33
     Search ThermoFisher Antibodies for DHX33
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX33
     Browse compounds at ApexBio
     Search Addgene for plasmids for DHX33
      Search eBioscience for proteins for DHX33
      Search eBioscience for elisas for DHX33
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for DHX33
     antibodies-online antibodies for DHX33 (5 products)
     antibodies-online kits for DHX33 (4 products)
      Search antibodies-online for peptides for DHX33
     antibodies-online proteins for DHX33 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DHX33 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4