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Aliases for DHX33 Gene

Aliases for DHX33 Gene

  • DEAH-Box Helicase 33 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 33 2 3
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 33 2 3
  • DEAH Box Protein 33 3 4
  • DDX33 3 4
  • Putative ATP-Dependent RNA Helicase DHX33 3
  • EC 3.6.4.13 4
  • EC 3.6.1 61

External Ids for DHX33 Gene

Previous HGNC Symbols for DHX33 Gene

  • DDX33

Previous GeneCards Identifiers for DHX33 Gene

  • GC17M005292
  • GC17M005546
  • GC17M005286
  • GC17M005236
  • GC17M005360

Summaries for DHX33 Gene

Entrez Gene Summary for DHX33 Gene

  • This gene encodes a member of the DEAD box protein family. The DEAD box proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

GeneCards Summary for DHX33 Gene

DHX33 (DEAH-Box Helicase 33) is a Protein Coding gene. Among its related pathways are Toll-Like receptor Signaling Pathways. GO annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DHX16.

UniProtKB/Swiss-Prot for DHX33 Gene

  • Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. Important element of nucleolar organization.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX33 Gene

Genomics for DHX33 Gene

Regulatory Elements for DHX33 Gene

Enhancers for DHX33 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G004965 1.4 ENCODE dbSUPER 18.1 +500.4 500444 5.4 CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 SPAG7 ZNF232 INCA1 CHRNE LOC100130950 LOC101927979 KIF1C DHX33 CAMTA2 SLC25A11
GH17G005416 1.6 Ensembl ENCODE dbSUPER 10.8 +50.1 50110 4.7 HDGF PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1 ZNF302 RABEP1 RPAIN ENSG00000263272 C1QBP DHX33 LOC101927979 DERL2 NUP88 GC17P005414
GH17G005240 1.4 Ensembl ENCODE dbSUPER 11.7 +226.7 226705 2.9 HDGF TBL1XR1 BMI1 PLRG1 YBX1 YY1 EGR1 CBX5 ZNF143 ZNF207 LOC101928000 DHX33 LOC101927979 ENSG00000263164 USP6 CAMTA2 GC17M005239
GH17G005525 1.5 FANTOM5 Ensembl ENCODE 10.7 -58.0 -57987 3.2 PKNOX1 ATF1 INSM2 SIN3A KLF17 FEZF1 GLI4 RFX5 ZNF366 FOS NLRP1 RPAIN DERL2 MIS12 DHX33 LOC105371507 RNU7-31P
GH17G004502 1.4 Ensembl ENCODE dbSUPER 10.7 +964.4 964418 4.5 HDGF PKNOX1 FOXA2 ZFP64 BMI1 TCF12 ZNF121 FOS EGR2 ZNF680 LOC101927979 ZNF594 ZNF232 LOC100130950 LOC105371492 INCA1 DHX33 MYBBP1A ENSG00000229782 GC17M004505
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DHX33 on UCSC Golden Path with GeneCards custom track

Promoters for DHX33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000090626 560 2200 HDGF MLX CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for DHX33 Gene

Chromosome:
17
Start:
5,440,912 bp from pter
End:
5,469,060 bp from pter
Size:
28,149 bases
Orientation:
Minus strand

Genomic View for DHX33 Gene

Genes around DHX33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX33 Gene

Proteins for DHX33 Gene

  • Protein details for DHX33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6R0-DHX33_HUMAN
    Recommended name:
    Putative ATP-dependent RNA helicase DHX33
    Protein Accession:
    Q9H6R0
    Secondary Accessions:
    • B4DHF9
    • Q4G149
    • Q5CZ73
    • Q9H5M9

    Protein attributes for DHX33 Gene

    Size:
    707 amino acids
    Molecular mass:
    78874 Da
    Quaternary structure:
    • Interacts with UBTF.
    SequenceCaution:
    • Sequence=AAH30017.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DHX33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHX33 Gene

Selected DME Specific Peptides for DHX33 Gene

Q9H6R0:
  • LDEAHERT
  • TQPRRVAA
  • TDGMLLRE
  • AETSITI
  • FLTGQEE
  • CYRLYTE
  • LKVIVMSAT
  • TNIAETS
  • TVPEIQR
  • GKTTQIPQ
  • TGSGKTTQ

Post-translational modifications for DHX33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHX33 Gene

Domains & Families for DHX33 Gene

Gene Families for DHX33 Gene

Suggested Antigen Peptide Sequences for DHX33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H6R0

UniProtKB/Swiss-Prot:

DHX33_HUMAN :
  • Belongs to the DEAD box helicase family. DEAH subfamily.
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX33: view

Function for DHX33 Gene

Molecular function for DHX33 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. Important element of nucleolar organization.

Enzyme Numbers (IUBMB) for DHX33 Gene

Gene Ontology (GO) - Molecular Function for DHX33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000182 rDNA binding IDA 21930779
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA 22658674
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
genes like me logo Genes that share ontologies with DHX33: view
genes like me logo Genes that share phenotypes with DHX33: view

Animal Models for DHX33 Gene

MGI Knock Outs for DHX33:

Animal Model Products

CRISPR Products

miRNA for DHX33 Gene

miRTarBase miRNAs that target DHX33

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DHX33 Gene

Localization for DHX33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX33 Gene

Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Predominantly in the nucleolus. During mitosis, localizes with the nucleolar organizing regions.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHX33 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for DHX33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IEA,IDA 21930779
GO:0005730 nucleolus IDA 21930779
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DHX33: view

Pathways & Interactions for DHX33 Gene

genes like me logo Genes that share pathways with DHX33: view

Pathways by source for DHX33 Gene

1 KEGG pathway for DHX33 Gene

Gene Ontology (GO) - Biological Process for DHX33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IBA --
GO:0045943 positive regulation of transcription from RNA polymerase I promoter IDA 21930779
genes like me logo Genes that share ontologies with DHX33: view

No data available for SIGNOR curated interactions for DHX33 Gene

Drugs & Compounds for DHX33 Gene

(3) Drugs for DHX33 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for DHX33 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DHX33: view

Transcripts for DHX33 Gene

Unigene Clusters for DHX33 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 33:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHX33 Gene

No ASD Table

Relevant External Links for DHX33 Gene

GeneLoc Exon Structure for
DHX33
ECgene alternative splicing isoforms for
DHX33

Expression for DHX33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHX33 Gene

Protein differential expression in normal tissues from HIPED for DHX33 Gene

This gene is overexpressed in Plasma (67.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DHX33 Gene



Protein tissue co-expression partners for DHX33 Gene

NURSA nuclear receptor signaling pathways regulating expression of DHX33 Gene:

DHX33

SOURCE GeneReport for Unigene cluster for DHX33 Gene:

Hs.250456

Evidence on tissue expression from TISSUES for DHX33 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with DHX33: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHX33 Gene

Orthologs for DHX33 Gene

This gene was present in the common ancestor of animals.

Orthologs for DHX33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHX33 34 35
  • 99.48 (n)
cow
(Bos Taurus)
Mammalia DHX33 35
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dhx33 34
  • 90.59 (n)
mouse
(Mus musculus)
Mammalia Dhx33 34 16 35
  • 90.26 (n)
dog
(Canis familiaris)
Mammalia DHX33 34 35
  • 85.97 (n)
oppossum
(Monodelphis domestica)
Mammalia DHX33 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 72 (a)
OneToMany
-- 35
  • 72 (a)
OneToMany
chicken
(Gallus gallus)
Aves DHX33 34
  • 79.18 (n)
lizard
(Anolis carolinensis)
Reptilia DHX33 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx33 34
  • 74.08 (n)
Str.4876 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6757 34
zebrafish
(Danio rerio)
Actinopterygii DHX33 35
  • 73 (a)
OneToOne
LOC796505 34
  • 69.51 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006138 34
  • 54.46 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4901 34 35
  • 51.79 (n)
worm
(Caenorhabditis elegans)
Secernentea T05E8.3 35
  • 30 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2140 34
Species where no ortholog for DHX33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHX33 Gene

ENSEMBL:
Gene Tree for DHX33 (if available)
TreeFam:
Gene Tree for DHX33 (if available)

Paralogs for DHX33 Gene

Paralogs for DHX33 Gene

(11) SIMAP similar genes for DHX33 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DHX33: view

Variants for DHX33 Gene

Sequence variations from dbSNP and Humsavar for DHX33 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000230318 -- 5,444,585(+) GTGTT(A/G)GGGCA intron-variant
rs1000334367 -- 5,445,886(+) AGATA(C/T)CTTTC intron-variant
rs1000342569 -- 5,450,770(+) TGTAA(C/T)GTACA intron-variant
rs1000343103 -- 5,462,694(+) CTGCT(-/GAGA)GAGAC intron-variant, upstream-variant-2KB
rs1000450321 -- 5,446,128(+) CACCA(C/T)CACGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHX33 Gene

Variant ID Type Subtype PubMed ID
nsv1134590 CNV deletion 24896259
nsv574273 CNV gain 21841781

Variation tolerance for DHX33 Gene

Residual Variation Intolerance Score: 62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.49; 85.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHX33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DHX33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX33 Gene

Disorders for DHX33 Gene

Relevant External Links for DHX33

Genetic Association Database (GAD)
DHX33
Human Genome Epidemiology (HuGE) Navigator
DHX33
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHX33

No disorders were found for DHX33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX33 Gene

Publications for DHX33 Gene

  1. Identification of DHX33 as a mediator of rRNA synthesis and cell growth. (PMID: 21930779) Zhang Y. … Weber J.D. (Mol. Cell. Biol. 2011) 3 4 64
  2. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64
  3. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S. … Kang D. (Hum. Immunol. 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for DHX33 Gene

Sources for DHX33 Gene

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