Aliases for DHX32 Gene
Aliases for DHX32 Gene
External Ids for DHX32 Gene
- HGNC: 16717
- Entrez Gene: 55760
- Ensembl: ENSG00000089876
- OMIM: 607960
- UniProtKB: Q7L7V1
Previous HGNC Symbols for DHX32 Gene
- DDX32
Previous GeneCards Identifiers for DHX32 Gene
- GC10M127099
- GC10M127515
- GC10M121214
Summaries for DHX32 Gene
-
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates 2 transcript variants, but the full length nature of one of the variants has not been defined. [provided by RefSeq, Jul 2008]
GeneCards Summary for DHX32 Gene
DHX32 (DEAH-Box Helicase 32 (Putative)) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ATP-dependent RNA helicase activity. An important paralog of this gene is DQX1.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX32 Gene
Genomics for DHX32 Gene
GeneHancer (GH) Regulatory Elements for DHX32 Gene
- Top Transcription factor binding sites by QIAGEN in the DHX32 gene promoter:
Regulatory Element Products
Genomic Locations for DHX32 Gene
- chr10:125,836,337-125,896,436
- (GRCh38/hg38)
- Size:
- 60,100 bases
- Orientation:
- Minus strand
- chr10:127,524,906-127,585,005
- (GRCh37/hg19)
Genomic View for DHX32 Gene
- Cytogenetic band:
-
- 10q26.2 by Ensembl
- 10q26.2 by Entrez Gene
- 10q26.2 by HGNC


RefSeq DNA sequence for DHX32 Gene
Proteins for DHX32 Gene
-
Protein details for DHX32 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7L7V1-DHX32_HUMAN
- Recommended name:
- Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32
- Protein Accession:
- Q7L7V1
- A8MSV2
- D3DRF9
- Q49AG5
- Q5T3L0
- Q5T3L5
- Q96NY1
- Q9BUN0
- Q9H769
- Q9NSL5
- Q9NV74
- Q9NVJ7
Protein attributes for DHX32 Gene
- Size:
- 743 amino acids
- Molecular mass:
- 84419 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH37925.1; Type=Frameshift; Positions=439; Evidence={ECO:0000305}; Sequence=BAB15029.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for DHX32 Gene
Selected DME Specific Peptides for DHX32 Gene
- Q7L7V1:
-
- ALEDLDYLAAL
- IMSEFPLDPQ
- EFPLDPQL
Post-translational modifications for DHX32 Gene
- Ubiquitination at Lys596
Other Protein References for DHX32 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
Abcam antibodies for DHX32
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- GeneTex DHX32 antibody for DHX32
-
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Protein Products
-
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Assay Products
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Domains & Families for DHX32 Gene
Gene Families for DHX32 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for DHX32 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for DHX32 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q7L7V1- Family:
-
- Belongs to the DEAD box helicase family. DEAH subfamily.
Function for DHX32 Gene
Molecular function for DHX32 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + H(2)O = ADP + phosphate.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by ionomycin in T-lymphocytes. Down-regulated in acute lymphoblastic leukemia.
Enzyme Numbers (IUBMB) for DHX32 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | IBA | -- |
GO:0004004 | ATP-dependent RNA helicase activity | IBA | -- |
GO:0004386 | helicase activity | IEA | -- |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0005524 | ATP binding | IEA | -- |
Phenotypes for DHX32 Gene
- GenomeRNAi human phenotypes for DHX32:
Animal Model Products
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-
-
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-
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CRISPR Products
-
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-
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-
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miRNA for DHX32 Gene
- miRTarBase miRNAs that target DHX32
miRNA Products
- Search ViGene Biosciences for DHX32
Inhibitory RNA Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available DHX32 gene related products
- orf clones - Search results for available DHX32 gene related products
- Applied Biological Materials Clones for DHX32
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for DHX32
-
ViGene Biosciences adenoviral particle packaged cDNA for DHX32 gene
-
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-
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No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHX32 Gene
Localization for DHX32 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DHX32 Gene
- Nucleus. Mitochondrion.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005681 | spliceosomal complex | IBA | -- |
GO:0005737 | cytoplasm | IBA | -- |
GO:0005739 | mitochondrion | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for DHX32 Gene
Pathways & Interactions for DHX32 Gene
Interacting Proteins for DHX32 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000398 | mRNA splicing, via spliceosome | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for DHX32 Gene
Drugs & Compounds for DHX32 Gene
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Full agonist, Agonist | 58-64-0 |
|
Transcripts for DHX32 Gene
mRNA/cDNA for DHX32 Gene
- (3) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (175) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for DHX32 Gene
CRISPR Products
-
OriGene CRISPR knockouts for DHX32
- genomics-online: gRNA clones - Search results for available DHX32 gene related products
- Applied Biological Materials CRISPR for DHX32
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DHX32
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miRNA Products
- Search ViGene Biosciences for DHX32
Inhibitory RNA Products
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-
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Clone Products
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- VectorBuilder custom plasmid, inducible vectors for DHX32
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available DHX32 gene related products
- orf clones - Search results for available DHX32 gene related products
- Applied Biological Materials Clones for DHX32
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||
SP5: |
Expression for DHX32 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
- Oviduct
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Intestine (Gastrointestinal Tract)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DHX32 Gene
NURSA nuclear receptor signaling pathways regulating expression of DHX32 Gene:
DHX32SOURCE GeneReport for Unigene cluster for DHX32 Gene:
Hs.370292mRNA Expression by UniProt/SwissProt for DHX32 Gene:
Q7L7V1-DHX32_HUMANEvidence on tissue expression from TISSUES for DHX32 Gene
- Nervous system(4.7)
- Intestine(4.2)
- Kidney(4.2)
Primer Products
-
OriGene qPCR primer pairs for DHX32
- genomics-online: primer clones - Search results for available DHX32 gene related products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHX32 Gene
Orthologs for DHX32 Gene
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | DHX32 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | DHX32 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | DHX32 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Dhx32 33 |
|
||
mouse (Mus musculus) |
Mammalia | Dhx32 33 16 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | DHX32 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | DHX32 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | LOC768812 33 |
|
||
DHX32 34 |
|
OneToOne | |||
tropical clawed frog (Silurana tropicalis) |
Amphibia | dhx32 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | dhx32 33 |
|
||
dhx32b 34 |
|
OneToMany | |||
dhx32a 34 |
|
OneToMany | |||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PRP43 34 |
|
OneToMany |
- Species where no ortholog for DHX32 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for DHX32 Gene
Variants for DHX32 Gene
SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
VAR_035843 | A breast cancer sample | p.Pro209Arg | |||
rs1000006982 | -- | 125,884,989(-) | T/C | genic_upstream_transcript_variant, intron_variant | |
rs1000118253 | -- | 125,897,920(-) | G/A | upstream_transcript_variant | |
rs1000227523 | -- | 125,882,970(-) | A/G | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
rs1000237999 | -- | 125,897,509(-) | C/G | upstream_transcript_variant |
Additional Variant Information for DHX32 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DHX32
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX32 Gene
Disorders for DHX32 Gene
Additional Disease Information for DHX32
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for DHX32 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX32 Gene
Publications for DHX32 Gene
- Nuclear and mitochondrial localization of the putative RNA helicase DHX32. (PMID: 16959245) Alli Z … Abdelhaleem M (Experimental and molecular pathology 2006) 2 3 4 58
- Genomic structure of the human BCCIP gene and its expression in cancer. (PMID: 12527204) Meng X … Shen Z (Gene 2003) 3 4 22 58
- The activation-induced expression of DHX32 in Jurkat T cells is specific and involves calcium and nuclear factor of activated T cells. (PMID: 16414036) Alli Z … Abdelhaleem M (Cellular immunology 2005) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The novel helicase homologue DDX32 is down-regulated in acute lymphoblastic leukemia. (PMID: 12163057) Abdelhaleem M (Leukemia research 2002) 3 4 58
Products for DHX32 Gene
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- Invitrogen Antibodies for DHX32
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- Cyagen custom Knockout/knockin (KOKI) mouse models for DHX32
- VectorBuilder custom plasmid, inducible vectors for DHX32
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DHX32
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available DHX32 related products ranked by validation data
- antibodies-online: Search results for 3 available DHX32 Elisa Kits ranked by validation data
- Compare Top DHX32 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 5 available DHX32 Proteins ranked by validation data
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Sources for DHX32 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew