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Aliases for DHX32 Gene

Aliases for DHX32 Gene

  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 32 2 3
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 32 2 3
  • DEAD/H Helicase-Like Protein 1 3 4
  • DEAH Box Protein 32 3 4
  • DEAD/H Box 32 3 4
  • HuDDX32 3 4
  • DDX32 3 4
  • DHLP1 3 4
  • DEAD/H Helicase-Like Protein-1 3
  • EC 4
  • EC 3.6.1 63

External Ids for DHX32 Gene

Previous HGNC Symbols for DHX32 Gene

  • DDX32

Previous GeneCards Identifiers for DHX32 Gene

  • GC10M127099
  • GC10M127515
  • GC10M121214

Summaries for DHX32 Gene

Entrez Gene Summary for DHX32 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates 2 transcript variants, but the full length nature of one of the variants has not been defined. [provided by RefSeq, Jul 2008]

GeneCards Summary for DHX32 Gene

DHX32 (DEAH (Asp-Glu-Ala-His) Box Polypeptide 32) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and ATP-dependent RNA helicase activity. An important paralog of this gene is DHX35.

Gene Wiki entry for DHX32 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX32 Gene

Genomics for DHX32 Gene

Regulatory Elements for DHX32 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DHX32 Gene

125,836,337 bp from pter
125,896,436 bp from pter
60,100 bases
Minus strand

Genomic View for DHX32 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHX32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX32 Gene

Proteins for DHX32 Gene

  • Protein details for DHX32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32
    Protein Accession:
    Secondary Accessions:
    • A8MSV2
    • D3DRF9
    • Q49AG5
    • Q5T3L0
    • Q5T3L5
    • Q96NY1
    • Q9BUN0
    • Q9H769
    • Q9NSL5
    • Q9NV74
    • Q9NVJ7

    Protein attributes for DHX32 Gene

    743 amino acids
    Molecular mass:
    84419 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH37925.1; Type=Frameshift; Positions=439; Evidence={ECO:0000305}; Sequence=BAB15029.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DHX32 Gene


neXtProt entry for DHX32 Gene

Proteomics data for DHX32 Gene at MOPED

Selected DME Specific Peptides for DHX32 Gene

Post-translational modifications for DHX32 Gene

  • Ubiquitination at Lys 596
  • Modification sites at PhosphoSitePlus

Other Protein References for DHX32 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for DHX32 Gene

Gene Families for DHX32 Gene

Protein Domains for DHX32 Gene

Suggested Antigen Peptide Sequences for DHX32 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DEAH subfamily.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX32: view

Function for DHX32 Gene

Molecular function for DHX32 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Induction:
Up-regulated by ionomycin in T-lymphocytes. Down-regulated in acute lymphoblastic leukemia.

Enzyme Numbers (IUBMB) for DHX32 Gene

Gene Ontology (GO) - Molecular Function for DHX32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
GO:0044822 poly(A) RNA binding IBA --
genes like me logo Genes that share ontologies with DHX32: view

Phenotypes for DHX32 Gene

genes like me logo Genes that share phenotypes with DHX32: view

Animal Model Products

miRNA for DHX32 Gene

miRTarBase miRNAs that target DHX32

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DHX32

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for DHX32 Gene

Localization for DHX32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX32 Gene

Nucleus. Mitochondrion.

Subcellular locations from

Jensen Localization Image for DHX32 Gene COMPARTMENTS Subcellular localization image for DHX32 gene
Compartment Confidence
mitochondrion 3
nucleus 3

Gene Ontology (GO) - Cellular Components for DHX32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005681 spliceosomal complex IBA --
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with DHX32: view

Pathways & Interactions for DHX32 Gene

SuperPathways for DHX32 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHX32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IBA --
genes like me logo Genes that share ontologies with DHX32: view

No data available for Pathways by source and SIGNOR curated interactions for DHX32 Gene

Drugs & Compounds for DHX32 Gene

(1) Drugs for DHX32 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DHX32 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with DHX32: view

Transcripts for DHX32 Gene

mRNA/cDNA for DHX32 Gene

Unigene Clusters for DHX32 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 32:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DHX32

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX32 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7
SP1: -
SP2: - - - -
SP3: -
SP4: - - - -

Relevant External Links for DHX32 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHX32 Gene

mRNA expression in normal human tissues for DHX32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DHX32 Gene

This gene is overexpressed in NK cells (20.9), Salivary gland (12.4), and Testis (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHX32 Gene

SOURCE GeneReport for Unigene cluster for DHX32 Gene Hs.370292

mRNA Expression by UniProt/SwissProt for DHX32 Gene

Tissue specificity: Expressed in lymphoid tissues (at protein level). Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung, lymphoid tissues and blood leukocytes.
genes like me logo Genes that share expression patterns with DHX32: view

Protein tissue co-expression partners for DHX32 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DHX32 Gene

Orthologs for DHX32 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DHX32 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DHX32 35
  • 87.74 (n)
  • 89.49 (a)
DHX32 36
  • 89 (a)
(Canis familiaris)
Mammalia DHX32 35
  • 89.32 (n)
  • 91.79 (a)
DHX32 36
  • 92 (a)
(Mus musculus)
Mammalia Dhx32 35
  • 83.51 (n)
  • 88.14 (a)
Dhx32 16
Dhx32 36
  • 87 (a)
(Pan troglodytes)
Mammalia DHX32 35
  • 99.42 (n)
  • 99.73 (a)
DHX32 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Dhx32 35
  • 84.14 (n)
  • 87.87 (a)
(Monodelphis domestica)
Mammalia DHX32 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia DHX32 36
  • 38 (a)
(Gallus gallus)
Aves LOC768812 35
  • 69.71 (n)
  • 69.58 (a)
DHX32 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx32 35
  • 66.62 (n)
  • 64.36 (a)
(Danio rerio)
Actinopterygii dhx32 35
  • 60.31 (n)
  • 57.64 (a)
dhx32a 36
  • 53 (a)
dhx32b 36
  • 55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP43 36
  • 34 (a)
Species with no ortholog for DHX32:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DHX32 Gene

Gene Tree for DHX32 (if available)
Gene Tree for DHX32 (if available)

Paralogs for DHX32 Gene

Paralogs for DHX32 Gene

(7) SIMAP similar genes for DHX32 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DHX32: view

Variants for DHX32 Gene

Sequence variations from dbSNP and Humsavar for DHX32 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1317529 -- 125,881,297(+) CACTG(A/G)GCCTC utr-variant-5-prime
rs1539315 -- 125,860,018(-) CATGA(C/G)TTAGC intron-variant
rs2366046 -- 125,859,049(+) TGTTT(G/T)TTTTT intron-variant
rs2366047 -- 125,859,053(+) TTTTT(G/T)TTTTT intron-variant
rs2366048 -- 125,859,057(+) ttttt(G/T)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHX32 Gene

Variant ID Type Subtype PubMed ID
nsv428241 CNV Loss 18775914
dgv324e1 CNV Complex 17122850
nsv8737 CNV Loss 18304495

Variation tolerance for DHX32 Gene

Residual Variation Intolerance Score: 29.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.32; 53.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHX32 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX32 Gene

Disorders for DHX32 Gene

Relevant External Links for DHX32

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DHX32: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX32 Gene

Publications for DHX32 Gene

  1. Genomic structure of the human BCCIP gene and its expression in cancer. (PMID: 12527204) Meng X. … Shen Z. (Gene 2003) 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 67
  5. Up-regulation and clinical relevance of novel helicase homologue DHX32 in colorectal cancer. (PMID: 19161603) Huang C. … Zhang Z. (J. Exp. Clin. Cancer Res. 2009) 67

Products for DHX32 Gene

Sources for DHX32 Gene

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