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Aliases for DHX32 Gene

Aliases for DHX32 Gene

  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 32 2 3
  • DDX32 3 4 6
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 32 2 3
  • DEAD/H Helicase-Like Protein 1 3 4
  • DEAH Box Protein 32 3 4
  • DEAD/H Box 32 3 4
  • HuDDX32 3 4
  • DHLP1 3 4
  • Putative Pre-MRNA-Splicing Factor ATP-Dependent RNA Helicase DHX32 3
  • DEAD/H Helicase-Like Protein-1 3
  • EC 3.6.4.13 4
  • EC 3.6.1 63

External Ids for DHX32 Gene

Previous HGNC Symbols for DHX32 Gene

  • DDX32

Previous GeneCards Identifiers for DHX32 Gene

  • GC10M127099
  • GC10M127515
  • GC10M121214

Summaries for DHX32 Gene

Entrez Gene Summary for DHX32 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates 2 transcript variants, but the full length nature of one of the variants has not been defined. [provided by RefSeq, Jul 2008]

GeneCards Summary for DHX32 Gene

DHX32 (DEAH (Asp-Glu-Ala-His) Box Polypeptide 32) is a Protein Coding gene. GO annotations related to this gene include helicase activity. An important paralog of this gene is DHX35.

Gene Wiki entry for DHX32 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX32 Gene

Genomics for DHX32 Gene

Regulatory Elements for DHX32 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DHX32 Gene

Start:
125,836,337 bp from pter
End:
125,896,436 bp from pter
Size:
60,100 bases
Orientation:
Minus strand

Genomic View for DHX32 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHX32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX32 Gene

Proteins for DHX32 Gene

  • Protein details for DHX32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L7V1-DHX32_HUMAN
    Recommended name:
    Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32
    Protein Accession:
    Q7L7V1
    Secondary Accessions:
    • A8MSV2
    • D3DRF9
    • Q49AG5
    • Q5T3L0
    • Q5T3L5
    • Q96NY1
    • Q9BUN0
    • Q9H769
    • Q9NSL5
    • Q9NV74
    • Q9NVJ7

    Protein attributes for DHX32 Gene

    Size:
    743 amino acids
    Molecular mass:
    84419 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH37925.1; Type=Frameshift; Positions=439; Evidence={ECO:0000305}; Sequence=BAB15029.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DHX32 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHX32 Gene

Proteomics data for DHX32 Gene at MOPED

Selected DME Specific Peptides for DHX32 Gene

Post-translational modifications for DHX32 Gene

  • Ubiquitination at Lys596
  • Modification sites at PhosphoSitePlus

Other Protein References for DHX32 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for DHX32 Gene

Gene Families for DHX32 Gene

HGNC:
  • DHX :DEAH-boxes

Protein Domains for DHX32 Gene

Suggested Antigen Peptide Sequences for DHX32 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L7V1

UniProtKB/Swiss-Prot:

DHX32_HUMAN :
  • Q7L7V1
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX32: view

Function for DHX32 Gene

Molecular function for DHX32 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Induction: Up-regulated by ionomycin in T-lymphocytes. Down-regulated in acute lymphoblastic leukemia.

Enzyme Numbers (IUBMB) for DHX32 Gene

Gene Ontology (GO) - Molecular Function for DHX32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
GO:0044822 poly(A) RNA binding IBA --
genes like me logo Genes that share ontologies with DHX32: view

Phenotypes for DHX32 Gene

GenomeRNAi human phenotypes for DHX32:
genes like me logo Genes that share phenotypes with DHX32: view

Animal Model Products

CRISPR Products

miRNA for DHX32 Gene

miRTarBase miRNAs that target DHX32

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DHX32 Gene

Localization for DHX32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX32 Gene

Nucleus. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHX32 Gene COMPARTMENTS Subcellular localization image for DHX32 gene
Compartment Confidence
mitochondrion 5
nucleus 5

Gene Ontology (GO) - Cellular Components for DHX32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005681 spliceosomal complex IBA --
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with DHX32: view

Pathways for DHX32 Gene

SuperPathways for DHX32 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHX32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IBA --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with DHX32: view

No data available for Pathways by source for DHX32 Gene

Transcripts for DHX32 Gene

mRNA/cDNA for DHX32 Gene

Unigene Clusters for DHX32 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 32:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DHX32

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DHX32

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX32 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7
SP1: -
SP2: - - - -
SP3: -
SP4: - - - -
SP5:

Relevant External Links for DHX32 Gene

GeneLoc Exon Structure for
DHX32
ECgene alternative splicing isoforms for
DHX32

Expression for DHX32 Gene

mRNA expression in normal human tissues for DHX32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHX32 Gene

SOURCE GeneReport for Unigene cluster for DHX32 Gene Hs.370292

mRNA Expression by UniProt/SwissProt for DHX32 Gene

Q7L7V1-DHX32_HUMAN
Tissue specificity: Expressed in lymphoid tissues (at protein level). Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung, lymphoid tissues and blood leukocytes.
genes like me logo Genes that share expressions with DHX32: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DHX32 Gene

Orthologs for DHX32 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DHX32 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHX32 35
  • 99.42 (n)
  • 99.73 (a)
DHX32 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DHX32 35
  • 87.74 (n)
  • 89.49 (a)
DHX32 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DHX32 35
  • 89.32 (n)
  • 91.79 (a)
DHX32 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dhx32 35
  • 83.51 (n)
  • 88.14 (a)
Dhx32 16
Dhx32 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DHX32 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DHX32 36
  • 38 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dhx32 35
  • 84.14 (n)
  • 87.87 (a)
chicken
(Gallus gallus)
Aves DHX32 36
  • 67 (a)
OneToOne
LOC768812 35
  • 69.71 (n)
  • 69.58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx32 35
  • 66.62 (n)
  • 64.36 (a)
zebrafish
(Danio rerio)
Actinopterygii dhx32 35
  • 60.31 (n)
  • 57.64 (a)
dhx32a 36
  • 53 (a)
OneToMany
dhx32b 36
  • 55 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP43 36
  • 34 (a)
OneToMany
Species with no ortholog for DHX32:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DHX32 Gene

ENSEMBL:
Gene Tree for DHX32 (if available)
TreeFam:
Gene Tree for DHX32 (if available)

Paralogs for DHX32 Gene

Paralogs for DHX32 Gene

Selected SIMAP similar genes for DHX32 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DHX32: view

Variants for DHX32 Gene

Sequence variations from dbSNP and Humsavar for DHX32 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1317529 -- 125,881,297(+) CACTG(A/G)GCCTC utr-variant-5-prime
rs1539315 -- 125,860,018(-) CATGA(C/G)TTAGC intron-variant
rs2366046 -- 125,859,049(+) TGTTT(G/T)TTTTT intron-variant
rs2366047 -- 125,859,053(+) TTTTT(G/T)TTTTT intron-variant
rs2366048 -- 125,859,057(+) ttttt(G/T)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHX32 Gene

Variant ID Type Subtype PubMed ID
nsv428241 CNV Loss 18775914
dgv324e1 CNV Complex 17122850
nsv8737 CNV Loss 18304495

Relevant External Links for DHX32 Gene

HapMap Linkage Disequilibrium report
DHX32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX32 Gene

Disorders for DHX32 Gene

Relevant External Links for DHX32

Genetic Association Database (GAD)
DHX32
genes like me logo Genes that share disorders with DHX32: view

No data available for UniProtKB/Swiss-Prot for DHX32 Gene

Publications for DHX32 Gene

  1. Genomic structure of the human BCCIP gene and its expression in cancer. (PMID: 12527204) Meng X. … Shen Z. (Gene 2003) 3 4 23
  2. The novel helicase homologue DDX32 is down-regulated in acute lymphoblastic leukemia. (PMID: 12163057) Abdelhaleem M. (Leuk. Res. 2002) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The activation-induced expression of DHX32 in Jurkat T cells is specific and involves calcium and nuclear factor of activated T cells. (PMID: 16414036) Alli Z. … Abdelhaleem M. (Cell. Immunol. 2005) 3 4
  5. Nuclear and mitochondrial localization of the putative RNA helicase DHX32. (PMID: 16959245) Alli Z. … Abdelhaleem M. (Exp. Mol. Pathol. 2006) 3 4

Products for DHX32 Gene

Sources for DHX32 Gene

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