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DHX32 Gene

protein-coding   GIFtS: 51
GCID: GC10M127515

DEAH (Asp-Glu-Ala-His) Box Polypeptide 32

(Previous name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32)
(Previous symbol: DDX32)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEAH (Asp-Glu-Ala-His) Box Polypeptide 321 2     DEAD/H Helicase-Like Protein-12
DDX321 2 3 5     huDDX322
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 321 2     Putative Pre-MRNA-Splicing Factor ATP-Dependent RNA Helicase DHX322
DHLP12 3     EC 3.6.4.133
DEAD/H Box 322 3     HuDDX323
DEAD/H Helicase-Like Protein 12 3     EC 3.6.18
DEAH Box Protein 322 3     

External Ids:    HGNC: 167171   Entrez Gene: 557602   Ensembl: ENSG000000898767   OMIM: 6079605   UniProtKB: Q7L7V13   

Export aliases for DHX32 gene to outside databases

Previous GC identifers: GC10M127099 GC10M121214


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DHX32 Gene:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They
are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their
distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis,
spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of
this member has not been determined. Alternative splicing of this gene generates 2 transcript variants, but the
full length nature of one of the variants has not been defined. (provided by RefSeq, Jul 2008)

GeneCards Summary for DHX32 Gene:
DHX32 (DEAH (Asp-Glu-Ala-His) box polypeptide 32) is a protein-coding gene. Diseases associated with DHX32 include brain cancer, and breast and colorectal cancer. GO annotations related to this gene include helicase activity. An important paralog of this gene is DHX33.

Gene Wiki entry for DHX32 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the DHX32 gene promoter:
         RFX1   Spz1   NRSF form 1   SREBP-1c   NRSF form 2   YY1   SREBP-1b   N-Myc   SREBP-1a   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDHX32 promoter sequence
   Search Chromatin IP Primers for DHX32

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DHX32


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.2   Ensembl cytogenetic band:  10q26.2   HGNC cytogenetic band: 10q26.11-q26.2

DHX32 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHX32 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M127515:  view genomic region     (about GC identifiers)

Start:
127,524,906 bp from pter      End:
127,585,005 bp from pter
Size:
60,100 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DHX32_HUMAN, Q7L7V1 (See protein sequence)
Recommended Name: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32  
Size: 743 amino acids; 84419 Da
Sequence caution: Sequence=AAH37925.1; Type=Frameshift; Positions=439; Sequence=BAB15029.1; Type=Erroneous
initiation;
Secondary accessions: A8MSV2 D3DRF9 Q49AG5 Q5T3L0 Q5T3L5 Q96NY1 Q9BUN0 Q9H769 Q9NSL5 Q9NV74
Q9NVJ7
Alternative splicing: 2 isoforms:  Q7L7V1-1   Q7L7V1-2   

Explore the universe of human proteins at neXtProt for DHX32: NX_Q7L7V1

Explore proteomics data for DHX32 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys596
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for DHX32 (Q7L7V1)
     EFPLDPQL  IMSEFPLDPQ  ALEDLDYLAAL 


    See DHX32 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060650.2  
    ENSEMBL proteins: 
     ENSP00000357710   ENSP00000284690   ENSP00000406781   ENSP00000284688  

    DHX32 Human Recombinant Protein Products:

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    Novus Biologicals DHX32 Proteins
    Novus Biologicals DHX32 Lysate
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    Cloud-Clone Corp. Proteins for DHX32

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    LSBio Antibodies in human, mouse, rat for DHX32

    DHX32 Assay Products:

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    Cloud-Clone Corp. ELISAs for DHX32
    Cloud-Clone Corp. CLIAs for DHX32


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DHX: DEAH-boxes

    4 InterPro protein domains:
     IPR007502 Helicase-assoc_dom
     IPR011709 DUF1605
     IPR027417 P-loop_NTPase
     IPR014001 Helicase_ATP-bd

    Graphical View of Domain Structure for InterPro Entry Q7L7V1

    ProtoNet protein and cluster: Q7L7V1

    1 Blocks protein domain: IPB007502 Helicase-associated region

    UniProtKB/Swiss-Prot: DHX32_HUMAN, Q7L7V1
    Similarity: Belongs to the DEAD box helicase family. DEAH subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    DHX32 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DHX32_HUMAN, Q7L7V1
    Catalytic activity: ATP + H(2)O = ADP + phosphate
    Induction: Up-regulated by ionomycin in T-lymphocytes. Down-regulated in acute lymphoblastic leukemia

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004386helicase activity IEA--
    GO:0005524ATP binding IEA--
         
    DHX32 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DHX32:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DHX32
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DHX32

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DHX32
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DHX32

    miRNA
    Products:
        
    miRTarBase miRNAs that target DHX32:
    hsa-mir-335-5p (MIRT018169)

    Block miRNA regulation of human, mouse, rat DHX32 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate DHX32:
    hsa-miR-548am hsa-miR-1283 hsa-miR-548x hsa-miR-642b hsa-miR-548n hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidDHX32 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DHX32
    Predesigned siRNA for gene silencing in human, mouse, rat DHX32

    Gene Editing
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    OriGene ORF clones in mouse, rat for DHX32
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DHX32 (NM_018180)
    Sino Biological Human cDNA Clone for DHX32
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHX32
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX32

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for DHX32
    Browse ESI BIO Cell Lines and PureStem Progenitors for DHX32 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX32


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DHX32_HUMAN, Q7L7V1: Nucleus. Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005739mitochondrion IEA--

    DHX32 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DHX32
    Interactions:

        Search GeneGlobe Interaction Network for DHX32

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DHX32 (ENSP000002846904) via UniProtKB, MINT, STRING, and/or I2D (see all 178)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NOP58ENSP000002642794STRING: ENSP00000264279
    PLRG1ENSP000003031914STRING: ENSP00000303191
    PRPF19ENSP000002275244STRING: ENSP00000227524
    CRNKL1ENSP000003665574STRING: ENSP00000366557
    DHX38ENSP000002684824STRING: ENSP00000268482
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DHX32



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DHX32 gene: 
    NM_018180.2  

    Unigene Cluster for DHX32:

    DEAH (Asp-Glu-Ala-His) box polypeptide 32
    Hs.370292  [show with all ESTs]
    Unigene Representative Sequence: AF427340
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368721(uc001lje.1) ENST00000284690(uc001ljf.1 uc001ljg.1)
    ENST00000415732 ENST00000284688(uc009yam.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DHX32 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate DHX32:
    hsa-miR-548am hsa-miR-1283 hsa-miR-548x hsa-miR-642b hsa-miR-548n hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidDHX32 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DHX32
    Predesigned siRNA for gene silencing in human, mouse, rat DHX32
    Clone
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    OriGene clones in human, mouse for DHX32 (see all 6)
    OriGene ORF clones in mouse, rat for DHX32
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DHX32 (NM_018180)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHX32
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX32
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DHX32
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DHX32
      QuantiTect SYBR Green Assays in human, mouse, rat DHX32
      QuantiFast Probe-based Assays in human, mouse, rat DHX32

    Additional mRNA sequence: 

    AF427340.1 AF427341.1 AK001556.1 AK001751.1 AK024869.1 AK315430.1 AL162051.1 AY064250.1 
    BC002473.2 BC037925.1 BC068471.1 

    11 DOTS entries:

    DT.95322273  DT.95351362  DT.450133  DT.97785236  DT.92466957  DT.92466941  DT.121252111  DT.92466960 
    DT.95256388  DT.100038056  DT.121252122 

    Selected AceView cDNA sequences (see all 175):

    CD244959 BU623127 BM979010 BU730233 BM068824 BM766385 F08130 AF427340 
    CA422102 AI632405 BU632131 BM741863 H94915 AA570125 AA293266 BC002473 
    BM822980 BE782153 CA430535 NM_018180 BM967310 BM893963 AA742522 AI887598 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DHX32    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7
    SP1:                                                              -                     
    SP2:                    -     -     -           -                                       
    SP3:                    -                                                               
    SP4:                    -     -     -                             -                     
    SP5:                                                                                    


    ECgene alternative splicing isoforms for DHX32

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DHX32 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DHX32 Expression
    About this image


    DHX32 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    DHX32 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DHX32 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.370292

    UniProtKB/Swiss-Prot: DHX32_HUMAN, Q7L7V1
    Tissue specificity: Expressed in lymphoid tissues (at protein level). Expressed in brain, heart, skeletal muscle,
    colon, thymus, spleen, kidney, liver, small intestine, placenta, lung, lymphoid tissues and blood leukocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX32

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DHX32 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dhx321 , 5 DEAH (Asp-Glu-Ala-His) box polypeptide 321, 5 83.51(n)1
    88.14(a)1
      7 (77.32 cM)5
    1014371  NM_001286031.11  NP_001272960.11 
     1337209425 
    chicken
    (Gallus gallus)
    Aves LOC7688121 putative pre-mRNA-splicing factor ATP-dependent RNA more 69.71(n)
    69.58(a)
      768812  XM_003641504.2  XP_003641552.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia 480538212   -- 74.21(n)    48053821 
    zebrafish
    (Danio rerio)
    Actinopterygii 570933612   -- 69.72(n)    57093361 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRP436
    RNA helicase in the DEAH-box family, functions in ...
    34(a)
    1 → many
    VII(281634-283937) YGL120C


    ENSEMBL Gene Tree for DHX32 (if available)
    TreeFam Gene Tree for DHX32 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DHX32 gene
    DHX332  DHX162  DHX352  DHX152  DQX12  DHX82  
    7 SIMAP similar genes for DHX32 using alignment to 1 protein entry:     DHX32_HUMAN:
    DHX15    DQX1    DHX8    DHX16    DHX38    DHX33
    DHX35

    DHX32 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DHX32 (see all 508)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358434
    A breast cancer sample4--see VAR_0358432 P R mis40--------
    rs1812117701,2
    --127542909(+) CCTACA/GTGTAT 1 -- int10--------
    rs1853060931,2
    --127543025(+) TAAGTA/GAAAAA 1 -- int10--------
    rs1898039571,2
    --127543139(+) ATTAAA/CTCAAG 1 -- int10--------
    rs1818985361,2
    --127543304(+) GGTACA/GGTCCC 1 -- int10--------
    rs1430283881,2
    --127543602(+) ATCCTG/TGCCAA 1 -- int10--------
    rs1868834131,2
    --127543625(+) CTGTCG/TACTAA 1 -- int10--------
    rs1920790121,2
    --127543663(+) GCATGA/CGTCTG 1 -- int10--------
    rs1121665851,2
    C,F--127543664(+) CATGCG/ATCTGT 1 -- int12Minor allele frequency- A:0.04WA 120
    rs1136768771,2
    F--127543689(+) ACAAGG/TCTGAG 1 -- int11Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for DHX32 (127524906 - 127585005 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DHX32:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv428241CNV Loss18775914
    nsv8737CNV Loss18304495
    dgv324e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DHX32
    DNA2.0 Custom Variant and Variant Library Synthesis for DHX32

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607960    OMIM disorders: --

    10 diseases for DHX32:    
    About MalaCards
    brain cancer    breast and colorectal cancer    lymphoblastic leukemia    colorectal cancer
    tonsillitis    leukemia    cerebritis    thyroiditis
    endotheliitis    prostatitis


    DHX32 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DHX32

    Export disorders for DHX32 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DHX32 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with DHX32)
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    1. Genomic structure of the human BCCIP gene and its expression in cancer. (PubMed id 12527204)1, 2, 9 Meng X.... Shen Z. (Gene 2003)
    2. Nuclear and mitochondrial localization of the putative RNA helicase DHX32. (PubMed id 16959245)1, 2 Alli Z.... Abdelhaleem M. (Exp. Mol. Pathol. 2006)
    3. The activation-induced expression of DHX32 in Jurkat T cells is specific and involves calcium and nuclear factor of activated T cells. (PubMed id 16414036)1, 2 Alli Z.... Abdelhaleem M. (Cell. Immunol. 2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The novel helicase homologue DDX32 is down-regulated in acute lymphoblastic leukemia. (PubMed id 12163057)1, 2 Abdelhaleem M. (Leuk. Res. 2002)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55760 HGNC: 16717 AceView: DHX32 Ensembl:ENSG00000089876 euGenes: HUgn55760
    ECgene: DHX32 H-InvDB: DHX32

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DHX32 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DHX32 gene:
    Search GeneIP for patents involving DHX32

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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