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Aliases for DHX32 Gene

Aliases for DHX32 Gene

  • DEAH-Box Helicase 32 (Putative) 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 32 2 3
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 32 2 3
  • DEAH Box Protein 32 3 4
  • DEAD/H Box 32 3 4
  • HuDDX32 3 4
  • DDX32 3 4
  • DHLP1 3 4
  • Putative Pre-MRNA-Splicing Factor ATP-Dependent RNA Helicase DHX32 3
  • DEAD/H Helicase-Like Protein-1 3
  • DEAD/H Helicase-Like Protein 1 4
  • EC 4
  • EC 3.6.1 58

External Ids for DHX32 Gene

Previous HGNC Symbols for DHX32 Gene

  • DDX32

Previous GeneCards Identifiers for DHX32 Gene

  • GC10M127099
  • GC10M127515
  • GC10M121214

Summaries for DHX32 Gene

Entrez Gene Summary for DHX32 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates 2 transcript variants, but the full length nature of one of the variants has not been defined. [provided by RefSeq, Jul 2008]

GeneCards Summary for DHX32 Gene

DHX32 (DEAH-Box Helicase 32 (Putative)) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and ATP-dependent RNA helicase activity. An important paralog of this gene is DQX1.

Gene Wiki entry for DHX32 Gene

Additional gene information for DHX32 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX32 Gene

Genomics for DHX32 Gene

Regulatory Elements for DHX32 Gene

Enhancers for DHX32 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H125870 0.8 ENCODE dbSUPER 10.9 +24.7 24727 2.4 OSR2 PRDM6 FEZF1 PRDM10 PRDM4 TRIM28 UROS DHX32 FANK1 MMP21 ENSG00000277371 GC10P125883 GC10P125882
GH10H125912 0.9 ENCODE 0.4 -15.7 -15741 0.2 FOXA2 MLX RARA MIXL1 THAP11 HMG20B SP5 ZNF217 NFIL3 MIER3 DHX32 GNG10P1
GH10H125913 0.6 ENCODE 0.4 -17.3 -17322 0.3 FOSL1 TCF12 SMARCE1 ATF1 BRF2 TCF7L2 DHX32 GNG10P1
GH10H125914 0.6 ENCODE 0.4 -17.1 -17051 0.2 FOSL1 TCF12 SMARCE1 HMBOX1 CREB1 TCF7L2 DHX32 GNG10P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DHX32 on UCSC Golden Path with GeneCards custom track

Promoters for DHX32 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000034960 235 2399 ARID4B SIN3A DMAP1 YY1 ETS1 ZNF121 GLIS2 RUNX3 SP5 YY2

Genomic Locations for DHX32 Gene

Genomic Locations for DHX32 Gene
60,100 bases
Minus strand

Genomic View for DHX32 Gene

Genes around DHX32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX32 Gene

Proteins for DHX32 Gene

  • Protein details for DHX32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32
    Protein Accession:
    Secondary Accessions:
    • A8MSV2
    • D3DRF9
    • Q49AG5
    • Q5T3L0
    • Q5T3L5
    • Q96NY1
    • Q9BUN0
    • Q9H769
    • Q9NSL5
    • Q9NV74
    • Q9NVJ7

    Protein attributes for DHX32 Gene

    743 amino acids
    Molecular mass:
    84419 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH37925.1; Type=Frameshift; Positions=439; Evidence={ECO:0000305}; Sequence=BAB15029.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DHX32 Gene


neXtProt entry for DHX32 Gene

Selected DME Specific Peptides for DHX32 Gene


Post-translational modifications for DHX32 Gene

  • Ubiquitination at isoforms=2596
  • Modification sites at PhosphoSitePlus

Other Protein References for DHX32 Gene

Antibody Products

  • Abcam antibodies for DHX32
  • Santa Cruz Biotechnology (SCBT) Antibodies for DHX32

Domains & Families for DHX32 Gene

Gene Families for DHX32 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DHX32 Gene

Suggested Antigen Peptide Sequences for DHX32 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DEAD box helicase family. DEAH subfamily.
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX32: view

Function for DHX32 Gene

Molecular function for DHX32 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Induction:
Up-regulated by ionomycin in T-lymphocytes. Down-regulated in acute lymphoblastic leukemia.

Enzyme Numbers (IUBMB) for DHX32 Gene

Gene Ontology (GO) - Molecular Function for DHX32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DHX32: view
genes like me logo Genes that share phenotypes with DHX32: view

Animal Model Products

CRISPR Products

miRNA for DHX32 Gene

miRTarBase miRNAs that target DHX32

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHX32 Gene

Localization for DHX32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX32 Gene

Nucleus. Mitochondrion.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHX32 gene
Compartment Confidence
mitochondrion 4
nucleus 4

Gene Ontology (GO) - Cellular Components for DHX32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005681 spliceosomal complex IBA --
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with DHX32: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DHX32 Gene

Pathways & Interactions for DHX32 Gene

SuperPathways for DHX32 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHX32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IBA --
genes like me logo Genes that share ontologies with DHX32: view

No data available for Pathways by source and SIGNOR curated interactions for DHX32 Gene

Drugs & Compounds for DHX32 Gene

(3) Drugs for DHX32 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Nutra Agonist 0

(1) Additional Compounds for DHX32 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DHX32: view

Transcripts for DHX32 Gene

Unigene Clusters for DHX32 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 32:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX32 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7
SP1: -
SP2: - - - -
SP3: -
SP4: - - - -

Relevant External Links for DHX32 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHX32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHX32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DHX32 Gene

This gene is overexpressed in NK cells (20.9), Salivary gland (12.4), and Testis (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DHX32 Gene

Protein tissue co-expression partners for DHX32 Gene

NURSA nuclear receptor signaling pathways regulating expression of DHX32 Gene:


SOURCE GeneReport for Unigene cluster for DHX32 Gene:


mRNA Expression by UniProt/SwissProt for DHX32 Gene:

Tissue specificity: Expressed in lymphoid tissues (at protein level). Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung, lymphoid tissues and blood leukocytes.

Evidence on tissue expression from TISSUES for DHX32 Gene

  • Nervous system(4.7)
  • Intestine(4.2)
  • Kidney(4.2)
genes like me logo Genes that share expression patterns with DHX32: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHX32 Gene

Orthologs for DHX32 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DHX32 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DHX32 33 34
  • 99.42 (n)
(Canis familiaris)
Mammalia DHX32 33 34
  • 89.32 (n)
(Bos Taurus)
Mammalia DHX32 33 34
  • 87.74 (n)
(Rattus norvegicus)
Mammalia Dhx32 33
  • 84.14 (n)
(Mus musculus)
Mammalia Dhx32 33 16 34
  • 83.51 (n)
(Monodelphis domestica)
Mammalia DHX32 34
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia DHX32 34
  • 38 (a)
(Gallus gallus)
Aves LOC768812 33
  • 69.71 (n)
DHX32 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx32 33
  • 66.62 (n)
(Danio rerio)
Actinopterygii dhx32 33
  • 60.31 (n)
dhx32b 34
  • 55 (a)
dhx32a 34
  • 53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP43 34
  • 34 (a)
Species where no ortholog for DHX32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DHX32 Gene

Gene Tree for DHX32 (if available)
Gene Tree for DHX32 (if available)

Paralogs for DHX32 Gene

Paralogs for DHX32 Gene

(7) SIMAP similar genes for DHX32 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DHX32: view

Variants for DHX32 Gene

Sequence variations from dbSNP and Humsavar for DHX32 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_035843 A breast cancer sample
rs1000006982 -- 125,884,989(+) GGATG(C/T)ATGGG intron-variant
rs1000118253 -- 125,897,920(+) GGGAG(A/G)CTGAG intron-variant, upstream-variant-2KB
rs1000227523 -- 125,882,970(+) AACCA(A/G)TGATT intron-variant, upstream-variant-2KB
rs1000237999 -- 125,897,509(+) CAAAC(C/G)AAGTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DHX32 Gene

Variant ID Type Subtype PubMed ID
nsv8737 CNV loss 18304495
nsv428241 CNV loss 18775914
esv2759788 CNV gain 17122850

Variation tolerance for DHX32 Gene

Residual Variation Intolerance Score: 29.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.32; 53.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHX32 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX32 Gene

Disorders for DHX32 Gene

Relevant External Links for DHX32

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DHX32 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX32 Gene

Publications for DHX32 Gene

  1. Nuclear and mitochondrial localization of the putative RNA helicase DHX32. (PMID: 16959245) Alli Z … Abdelhaleem M (Experimental and molecular pathology 2006) 2 3 4 60
  2. Genomic structure of the human BCCIP gene and its expression in cancer. (PMID: 12527204) Meng X … Shen Z (Gene 2003) 3 4 22 60
  3. The activation-induced expression of DHX32 in Jurkat T cells is specific and involves calcium and nuclear factor of activated T cells. (PMID: 16414036) Alli Z … Abdelhaleem M (Cellular immunology 2005) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The novel helicase homologue DDX32 is down-regulated in acute lymphoblastic leukemia. (PMID: 12163057) Abdelhaleem M (Leukemia research 2002) 3 4 60

Products for DHX32 Gene

Sources for DHX32 Gene

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