Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DHX30 Gene

protein-coding   GIFtS: 51
GCID: GC03P047844

DEAH (Asp-Glu-Ala-His) box polypeptide 30

(Previous name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 30 )
(Previous symbol: DDX30)
 Explore 2 diseases affiliated with
DHX30 via our new
 Human Malady Compendium 
Biological research products
for DHX30
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
DEAH (Asp-Glu-Ala-His) Box Polypeptide 301 2     RETCOR2
DDX301 2 3     Putative ATP-Dependent RNA Helicase DHX302
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 301 2     Retina Co-Repressor2
KIAA08901 3     EC 3.6.4.133
DEAH Box Protein 302 3     EC 3.6.18
FLJ112141     

External Ids:    HGNC: 167161   Entrez Gene: 229072   Ensembl: ENSG000001321537   UniProtKB: Q7L2E33   

Export aliases for DHX30 gene to outside databases

Previous GC identifers: GC03P047663 GC03P047805 GC03P047819


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DHX30:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are
implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation
initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution
patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis,
and cellular growth and division. The family member encoded by this gene is a mitochondrial nucleoid protein that
associates with mitochondrial DNA. It has also been identified as a component of a transcriptional repressor complex
that functions in retinal development, and it is required to optimize the function of the zinc-finger antiviral
protein. Alternatively spliced transcript variants have been found for this gene. (provided by RefSeq, Feb 2013)

UniProtKB/Swiss-Prot: DHX30_HUMAN, Q7L2E3
Function: Required for optimal function of the zinc-finger antiviral protein ZC3HAV1 (By similarity). Associates with
mitochondrial DNA




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DHX30 gene promoter:
         TBP   p53   Egr-1   NF-kappaB   Egr-2   c-Rel   NF-kappaB2   SEF-1 (1)   NF-kappaB1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DHX30 promoter sequence
   Search SABiosciences Chromatin IP Primers for DHX30

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHX30


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p24.3-p22.1

DHX30 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHX30 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P047844:  view genomic region     (about GC identifiers)

Start:
47,844,399 bp from pter      End:
47,891,686 bp from pter
Size:
47,288 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DHX30_HUMAN, Q7L2E3 (See protein sequence)
Recommended Name: Putative ATP-dependent RNA helicase DHX30  
Size: 1194 amino acids; 133938 Da
Subunit: Identified in a complex with TFAM and SSBP1. Interacts with EIF2C1 and EIF2C2. Interacts (via N-terminus) with
ZC3HAV1 (via N-terminal domain) in an RNA-independent manner (By similarity)
Subcellular location: Isoform 2: Cytoplasm
Subcellular location: Isoform 1: Cytoplasm
Subcellular location: Mitochondrion. Cytoplasm (Potential). Mitochondrion matrix, mitochondrion nucleoid
Sequence caution: Sequence=BAA74913.2; Type=Erroneous initiation; Sequence=BAA92071.1; Type=Miscellaneous discrepancy;
Note=Probable cloning artifact;
1 PDB 3D structure from and Proteopedia for DHX30:
2DB2 (3D)    
Secondary accessions: A8K5F1 O94965 Q7Z753 Q96CH4 Q9NUQ0
Alternative splicing: 3 isoforms:  Q7L2E3-1   Q7L2E3-2   Q7L2E3-3   (Contains a phosphoserine at position 15)

Explore the universe of human proteins at neXtProt for DHX30: NX_Q7L2E3

Post-translational modifications:

  • Isoform 2 is phosphorylated on Ser-151
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7L2E3

  • 4/40 DME Specific Peptides for DHX30 (Q7L2E3) (see all 40)
     GDTGCGK  TVGTKTK  TNIAETS  WPCPMTF 

    DHX30 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_055781.2  NP_619520.1  

    ENSEMBL proteins: 
     ENSP00000405620   ENSP00000395166   ENSP00000379094   ENSP00000410571   ENSP00000343442  
     ENSP00000394682   ENSP00000392601  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: DHX30
    OriGene Protein Over-expression Lysate (see all 2): DHX30
    OriGene Custom Protein Services for DHX30 
    GenScript Custom Purified and Recombinant Proteins Services for DHX30
    Novus Biologicals DHX30 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DHX30

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--
    GO:0042645mitochondrial nucleoid IDA18063578


    DHX30 for ontologies           About GeneDecksing



    DHX30 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DHX30 
    GenScript Custom Superior Antibodies Services for DHX30
    Novus Biologicals DHX30 Antibodies
    Search for Antibodies for DHX30 at Abcam  
    Uscn Antibodies for DHX30
    Search ThermoFisher Antibodies for DHX30

    Assay Products for DHX30: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DHX30
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for DHX30


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    DHX30 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR007502 Helicase-assoc_dom
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR011709 DUF1605
     IPR002464 DNA/RNA_helicase_DEAH_CS
     IPR014001 Helicase_ATP-bd

    Graphical View of Domain Structure for InterPro Entry Q7L2E3

    ProtoNet protein and cluster: Q7L2E3

    2 Blocks protein families:
    IPB002464 ATP-dependent helicase
    IPB007502 Helicase-associated region


    UniProtKB/Swiss-Prot: DHX30_HUMAN, Q7L2E3
    Similarity: Belongs to the DEAD box helicase family. DEAH subfamily
    Similarity: Contains 1 DRBM (double-stranded RNA-binding) domain
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: DHX30_HUMAN, Q7L2E3
    Function: Required for optimal function of the zinc-finger antiviral protein ZC3HAV1 (By similarity). Associates with
    mitochondrial DNA
    Catalytic activity: ATP + H(2)O = ADP + phosphate

    Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 2): DHX30
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DHX30
    1 QIAGEN miScript miRNA Assays for microRNA that regulate DHX30:
    hsa-miR-3121-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DHX30 (see all 7)
    OriGene shRNA RFP: DHX30
    OriGene siRNA: DHX30
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DHX30

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DHX30

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DHX30 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DHX30 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): DHX30 (NM_138615)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHX30
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX30 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DHX30
    Search LifeMap BioReagents cell lines for DHX30

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX30

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003682chromatin binding IDA18063578
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--


    DHX30 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for DHX30:
     Decreased number of cells in m  Increased cell number in G1, a  Synthetic lethal with Ras 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DHX30

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/510 Interacting proteins for DHX30 (Q7L2E31, 2, 3 ENSP000003926014) via UniProtKB, MINT, STRING, and/or I2D (see all 510)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBL3Q127882, 3, ENSP000003318154MINT-4303156 MINT-4303865 MINT-4303875 MINT-4303170 MINT-4303314 I2D: score=3 STRING: ENSP00000331815
    NR2E3Q9Y5X42, 3MINT-4302975 MINT-4303674 MINT-4302998 MINT-4302946 MINT-4303427 I2D: score=3 
    RBL1P287492, 3, ENSP000003627684MINT-4303197 MINT-4303401 MINT-4303068 MINT-4303903 I2D: score=3 STRING: ENSP00000362768
    HDAC3O153792, 3, ENSP000003029674MINT-4303223 MINT-4303376 MINT-4303094 I2D: score=3 STRING: ENSP00000302967
    NCOR1O753762, 3, ENSP000002687124MINT-4303028 MINT-4303286 MINT-4303298 I2D: score=3 STRING: ENSP00000268712
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DHX30
    Search CenterWatch for drugs/clinical trials and news about DHX30 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DHX30 gene (3 alternative transcripts): 
    NM_014966.3  NM_138615.2  NM_138614.1  

    Unigene Cluster for DHX30:

    DEAH (Asp-Glu-Ala-His) box polypeptide 30
    Hs.517948  [show with all ESTs]
    Unigene Representative Sequence: NM_014966
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000472718(uc003crr.4) ENST00000445061 ENST00000476446 ENST00000415400
    ENST00000492893 ENST00000395745 ENST00000441384(uc003crs.2) ENST00000348968
    ENST00000457607(uc010hjr.1) ENST00000471082 ENST00000470959 ENST00000461905
    ENST00000474183 ENST00000446256(uc003crt.3 uc003cru.3)

    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 2): DHX30
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DHX30
    1 QIAGEN miScript miRNA Assays for microRNA that regulate DHX30:
    hsa-miR-3121-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DHX30 (see all 7)
    OriGene shRNA RFP: DHX30
    OriGene siRNA: DHX30
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DHX30
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DHX30 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DHX30 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): DHX30 (NM_138615)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHX30
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX30 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DHX30
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DHX30
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DHX30
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHX30

    Additional cDNA sequence: 

    AB020697.1 AK002076.1 AK096791.1 AK291266.1 BC014237.2 BC015029.1 BC020126.1 BC028405.1 
    BC038417.1 BC047335.1 BC063510.1 

    24/30 DOTS entries (see all 30):

    DT.448445  DT.100827390  DT.95159299  DT.91756949  DT.91756925  DT.120893595  DT.95159303  DT.91756928 
    DT.310715  DT.97783615  DT.120893539  DT.120893750  DT.100698083  DT.40131216  DT.102832597  DT.120893843 
    DT.70104578  DT.101984673  DT.100653404  DT.100827388  DT.120893615  DT.91696882  DT.102832601  DT.121608274 

    24/457 AceView cDNA sequences (see all 457):

    CD673957 BQ053840 BM995919 AK002076 BC038417 CA454590 AI244327 AJ710636 
    BU179205 CB159844 AI648464 BQ071124 BE294282 AI290176 BQ943356 BU190535 
    BM971467 AB020697 AW250994 NM_014966 BQ707019 AI027484 BQ682090 BQ649965 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for DHX30 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c · 14d ^
    SP1:                                -                 -                                         -                             -           -                     
    SP2:                                -           -     -                                         -                             -           -                     
    SP3:                                                                                            -                             -           -           -     -   
    SP4:                                -     -     -     -                                                                                                         
    SP5:                                -     -     -     -                                         -                                                               

    ExUns: 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26
    SP1:                                                                                    
    SP2:                                                                                    
    SP3:  -     -     -     -     -     -     -     -     -     -     -     -               
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for DHX30

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DHX30 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGGAGCGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See DHX30 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DHX30

    SOURCE GeneReport for Unigene cluster: Hs.517948
        SABiosciences Custom PCR Arrays for DHX30
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DHX30
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DHX30
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DHX30
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHX30
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX30

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DHX30 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves DHX301 DEAH (Asp-Glu-Ala-His) box polypeptide 30 75.27(n)
    78.64(a)
      420376  NM_001012851.1  NP_001012869.1 
    lizard
    (Anolis carolinensis)
    Reptilia DHX306
    --
    75(a)
    1 ↔ 1
    GL343620.1(192216-209390)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.3442 Transcribed sequence with weak similarity to protein more 69.59(n)    AL848634.2 
    zebrafish
    (Danio rerio)
    Actinopterygii dhx301 DEAH (Asp-Glu-Ala-His) box polypeptide 30 57.66(n)
    52.73(a)
      570735  XM_694247.6  XP_699339.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta bgcn6
    benign gonial cell neoplasm
    13(a)
    possible ortholog
    2R(19740801-19746314)


    ENSEMBL Gene Tree for DHX30 (if available)
    TreeFam Gene Tree for DHX30 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DHX30 gene
    DHX402  YTHDC22  DHX572  DHX352  DHX92  DHX292  DHX362  TDRD92  
    DHX332  DHX162  DHX382  DHX82  
    3 SIMAP similar genes for DHX30 using alignment to 3 protein entries:     DHX30_HUMAN (see all proteins):
    DHX36    HIG-1    DHX16

    DHX30 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/683 NCBI SNPs in DHX30 are shown (see all 683    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1817961481,2
    --47842473(+) TCTATC/TTTCCC 2 -- us2k10--------
    rs1859440631,2
    --47842528(+) CAGTAC/TTGGCC 2 -- us2k10--------
    rs1467760681,2
    --47842610(+) AGTTCA/GAGGCC 2 -- us2k10--------
    rs1157535561,2
    --47842635(+) GGTGAA/CACCAT 2 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1413854291,2
    --47842687(+) CACCT-/GTAATT 2 -- us2k10--------
    rs1161365131,2
    F,--47842998(+) CCCTTG/CTTCCA 2 -- us2k11Minor allele frequency- C:0.06WA 118
    rs1146943671,2
    F,--47843130(+) ACAATG/ATTGTC 2 -- us2k11Minor allele frequency- A:0.06WA 118
    rs1407293421,2
    --47843224(+) CAGATA/GTCCGT 2 -- us2k10--------
    rs1886788761,2
    --47843252(+) CTCCAC/TACAAC 2 -- us2k10--------
    rs1814180921,2
    --47843267(+) CACCAC/TGCCCT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DHX30 (47844399 - 47891686 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for DHX30
         2 CNVs: 0551 31105

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DHX30
    DNA2.0 Custom Variant and Variant Library Synthesis for DHX30

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DHX30 for disorders           About GeneDecksing

    2 diseases for DHX30:    About MalaCards
    glaucoma    immunodeficiency

    Human Genome Epidemiology (HuGE) Navigator: DHX30 (1 document)

    Export disorders for DHX30 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DHX30 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with DHX30)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T....Ohara O. (1998)
    2. The layered structure of human mitochondrial DNA nucleoids. (PubMed id 18063578)1, 2 Bogenhagen D.F....Burke S. (2008)
    3. Proteomic and functional analysis of Argonaute-containing mRNA- protein complexes in human cells. (PubMed id 17932509)1, 2 Hoeck J.... Meister G. (2007)
    4. Human mitochondrial DNA nucleoids are linked to protein folding machinery and metabolic enzymes at the mitochondrial inner membrane. (PubMed id 16825194)1, 2 Wang Y. and Bogenhagen D.F. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (2012)
    8. DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation. (PubMed id 22446626)1 Close P.... Svejstrup J.Q. (2012)
    9. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    10. In Pursuit of Synthetic Modulators for the Orphan Reti na-Specific Nuclear Receptor NR2E3. (PubMed id 23098562)1 Qin Q....Petrukhin K. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22907 HGNC: 16716 AceView: DHX30 Ensembl:ENSG00000132153 euGenes: HUgn22907
    ECgene: DHX30 H-InvDB: DHX30

    (According to HUGE)
    About This Section
    HUGE: KIAA0890

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DHX30 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DHX30 gene:
    Search GeneIP for patents involving DHX30

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for DHX30  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DHX30   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DHX30  
     OriGene Protein Over-expression Lysate for DHX30   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for DHX30   OriGene 3'-UTR Clone for DHX30  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DHX30   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DHX30  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for DHX30   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DHX30   OriGene Custom Protein Services for DHX30  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DHX30
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DHX30
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHX30
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DHX30
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHX30
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DHX30
     GenScript Custom Purified and Recombinant Proteins Services for DHX30 GenScript cDNA clones with any tag delivered in your preferred vector for DHX30
     GenScript Custom Assay Services for DHX30 GenScript Custom Superior Antibodies Services for DHX30
     GenScript Custom overexpressing Cell Line Services for DHX30 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in DHX30 promoter
     Search Chromatin IP Primers for DHX30
     RT2 qPCR Primer Assay in human, mouse, rat DHX30
     Search GNC Networks for DHX30
     SABiosciences Custom PCR Arrays for DHX30
     Search Tocris compounds for DHX30
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     DHX30 antibodies
     DHX30 lysates
     Search for Antibodies for DHX30 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for DHX30
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     DHX30 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for DHX30
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX30
     Browse SwitchGear 3'UTR luciferase reporter plasmids for DHX30
     SwitchGear Promoter luciferase reporter plasmids for DHX30
     Search ThermoFisher Antibodies for DHX30
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX30
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DHX30 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4