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Aliases for DHX30 Gene

Aliases for DHX30 Gene

  • DEAH (Asp-Glu-Ala-His) Box Helicase 30 2 3
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 30 2 3
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 30 2 3
  • DEAH Box Protein 30 3 4
  • DDX30 3 4
  • Putative ATP-Dependent RNA Helicase DHX30 3
  • Retina Co-Repressor 3
  • EC 3.6.4.13 4
  • KIAA0890 4
  • EC 3.6.1 63
  • RETCOR 3

External Ids for DHX30 Gene

Previous HGNC Symbols for DHX30 Gene

  • DDX30

Previous GeneCards Identifiers for DHX30 Gene

  • GC03P047663
  • GC03P047805
  • GC03P047819
  • GC03P047844

Summaries for DHX30 Gene

Entrez Gene Summary for DHX30 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The family member encoded by this gene is a mitochondrial nucleoid protein that associates with mitochondrial DNA. It has also been identified as a component of a transcriptional repressor complex that functions in retinal development, and it is required to optimize the function of the zinc-finger antiviral protein. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013]

GeneCards Summary for DHX30 Gene

DHX30 (DEAH (Asp-Glu-Ala-His) Box Helicase 30) is a Protein Coding gene. GO annotations related to this gene include RNA binding and ATP-dependent helicase activity. An important paralog of this gene is DHX29.

UniProtKB/Swiss-Prot for DHX30 Gene

  • Required for optimal function of the zinc-finger antiviral protein ZC3HAV1 (By similarity). Associates with mitochondrial DNA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX30 Gene

Genomics for DHX30 Gene

Regulatory Elements for DHX30 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DHX30 Gene

Start:
47,802,909 bp from pter
End:
47,850,196 bp from pter
Size:
47,288 bases
Orientation:
Plus strand

Genomic View for DHX30 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHX30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX30 Gene

Proteins for DHX30 Gene

  • Protein details for DHX30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L2E3-DHX30_HUMAN
    Recommended name:
    Putative ATP-dependent RNA helicase DHX30
    Protein Accession:
    Q7L2E3
    Secondary Accessions:
    • A8K5F1
    • O94965
    • Q7Z753
    • Q96CH4
    • Q9NUQ0

    Protein attributes for DHX30 Gene

    Size:
    1194 amino acids
    Molecular mass:
    133938 Da
    Quaternary structure:
    • Identified in a complex with TFAM and SSBP1. Interacts with AGO1 and AGO2. Interacts (via N-terminus) with ZC3HAV1 (via N-terminal domain) in an RNA-independent manner (By similarity).
    SequenceCaution:
    • Sequence=BAA74913.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA92071.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DHX30 Gene

    Alternative splice isoforms for DHX30 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHX30 Gene

Proteomics data for DHX30 Gene at MOPED

Post-translational modifications for DHX30 Gene

Domains for DHX30 Gene

Gene Families for DHX30 Gene

HGNC:
  • DHX :DEAH-boxes

Suggested Antigen Peptide Sequences for DHX30 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L2E3

UniProtKB/Swiss-Prot:

DHX30_HUMAN :
  • Q7L2E3
Domain:
  • Contains 1 DRBM (double-stranded RNA-binding) domain.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX30: view

Function for DHX30 Gene

Molecular function for DHX30 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function:
Required for optimal function of the zinc-finger antiviral protein ZC3HAV1 (By similarity). Associates with mitochondrial DNA.

Enzyme Numbers (IUBMB) for DHX30 Gene

Gene Ontology (GO) - Molecular Function for DHX30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003682 chromatin binding IDA 18063578
GO:0003725 double-stranded RNA binding IDA 21266579
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity --
genes like me logo Genes that share ontologies with DHX30: view
genes like me logo Genes that share phenotypes with DHX30: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DHX30

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DHX30 Gene

Localization for DHX30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX30 Gene

Isoform 2: Cytoplasm.
Isoform 1: Cytoplasm.
Mitochondrion. Cytoplasm. Mitochondrion matrix, mitochondrion nucleoid.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHX30 Gene COMPARTMENTS Subcellular localization image for DHX30 gene
Compartment Confidence
mitochondrion 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for DHX30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0042645 mitochondrial nucleoid IDA 18063578
genes like me logo Genes that share ontologies with DHX30: view

Pathways for DHX30 Gene

SuperPathways for DHX30 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHX30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006396 RNA processing IBA --
genes like me logo Genes that share ontologies with DHX30: view

No data available for Pathways by source for DHX30 Gene

Transcripts for DHX30 Gene

Unigene Clusters for DHX30 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 30:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DHX30

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX30 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c · 14d ^
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - -
SP6:
SP7: - - - -
SP8: - - - - -
SP9:
SP10:
SP11:
SP12:

ExUns: 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26
SP1:
SP2:
SP3: - - - - - - - - - - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for DHX30 Gene

GeneLoc Exon Structure for
DHX30
ECgene alternative splicing isoforms for
DHX30

Expression for DHX30 Gene

mRNA expression in normal human tissues for DHX30 Gene

Protein differential expression in normal tissues for DHX30 Gene

This gene is overexpressed in Bone marrow stromal cell (33.0) and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHX30 Gene

SOURCE GeneReport for Unigene cluster for DHX30 Gene Hs.517948

genes like me logo Genes that share expressions with DHX30: view

Expression partners for DHX30 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DHX30 Gene

Orthologs for DHX30 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DHX30 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DHX30 35
  • 91.22 (n)
  • 97.93 (a)
DHX30 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DHX30 35
  • 91.74 (n)
  • 98.45 (a)
DHX30 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dhx30 35
  • 89.15 (n)
  • 97.5 (a)
Dhx30 16
Dhx30 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DHX30 35
  • 98.99 (n)
  • 98.79 (a)
DHX30 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dhx30 35
  • 90.23 (n)
  • 97.74 (a)
oppossum
(Monodelphis domestica)
Mammalia DHX30 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
chicken
(Gallus gallus)
Aves DHX30 35
  • 75.21 (n)
  • 78.47 (a)
DHX30 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHX30 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx30 35
  • 67.42 (n)
  • 65.33 (a)
Str.344 35
zebrafish
(Danio rerio)
Actinopterygii dhx30 35
  • 58.56 (n)
  • 53.99 (a)
DHX30 36
  • 48 (a)
OneToOne
Species with no ortholog for DHX30:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DHX30 Gene

ENSEMBL:
Gene Tree for DHX30 (if available)
TreeFam:
Gene Tree for DHX30 (if available)

Paralogs for DHX30 Gene

Paralogs for DHX30 Gene

Selected SIMAP similar genes for DHX30 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DHX30: view

Variants for DHX30 Gene

Sequence variations from dbSNP and Humsavar for DHX30 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs3888 -- 47,816,085(+) AGGCA(C/T)TTAGT intron-variant, nc-transcript-variant
rs319693 -- 47,845,090(-) ACAGC(A/C)CCCCC intron-variant
rs319694 -- 47,843,463(-) GTCAC(A/G)GGCAA intron-variant
rs319695 -- 47,842,749(-) AAAAG(A/G)CCCTG intron-variant
rs1142721 -- 47,837,641(-) tggga(A/T)tacag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHX30 Gene

Variant ID Type Subtype PubMed ID
nsv834679 CNV Loss 17160897
nsv508916 CNV Insertion 20534489
nsv3808 CNV Insertion 18451855
nsv231 CNV Insertion 15895083
nsv10270 CNV Gain 18304495

Relevant External Links for DHX30 Gene

HapMap Linkage Disequilibrium report
DHX30

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX30 Gene

Disorders for DHX30 Gene

Relevant External Links for DHX30

Genetic Association Database (GAD)
DHX30
Human Genome Epidemiology (HuGE) Navigator
DHX30

No disorders were found for DHX30 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DHX30 Gene

Publications for DHX30 Gene

  1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Human mitochondrial DNA nucleoids are linked to protein folding machinery and metabolic enzymes at the mitochondrial inner membrane. (PMID: 16825194) Wang Y. … Bogenhagen D.F. (J. Biol. Chem. 2006) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The layered structure of human mitochondrial DNA nucleoids. (PMID: 18063578) Bogenhagen D.F. … Burke S. (J. Biol. Chem. 2008) 3 4
  5. Proteomic and functional analysis of Argonaute-containing mRNA- protein complexes in human cells. (PMID: 17932509) Hoeck J. … Meister G. (EMBO Rep. 2007) 3 4

Products for DHX30 Gene

Sources for DHX30 Gene

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