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Aliases for DHX29 Gene

Aliases for DHX29 Gene

  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 29 2 3
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 29 2 3
  • Nucleic Acid Helicase DDXx 3 4
  • DEAH Box Protein 29 3 4
  • DDX29 3 4
  • ATP-Dependent RNA Helicase DHX29 3
  • EC 3.6.4.13 4
  • EC 3.6.1 63

External Ids for DHX29 Gene

Previous HGNC Symbols for DHX29 Gene

  • DDX29

Previous GeneCards Identifiers for DHX29 Gene

  • GC05M054522
  • GC05M054567
  • GC05M054587
  • GC05M054552
  • GC05M051525

Summaries for DHX29 Gene

GeneCards Summary for DHX29 Gene

DHX29 (DEAH (Asp-Glu-Ala-His) Box Polypeptide 29) is a Protein Coding gene. Among its related pathways are Translational Control and Chromatin Regulation / Acetylation. GO annotations related to this gene include ATP-dependent helicase activity and ribosomal small subunit binding. An important paralog of this gene is DHX36.

UniProtKB/Swiss-Prot for DHX29 Gene

  • ATP-binding RNA helicase involved in translation initiation. Part of the 43S preinitiation complex that is required for efficient initiation on mammalian mRNAs with structured 5-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX29 Gene

Genomics for DHX29 Gene

Regulatory Elements for DHX29 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DHX29 Gene

Start:
55,256,245 bp from pter
End:
55,307,722 bp from pter
Size:
51,478 bases
Orientation:
Minus strand

Genomic View for DHX29 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHX29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX29 Gene

Proteins for DHX29 Gene

  • Protein details for DHX29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z478-DHX29_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DHX29
    Protein Accession:
    Q7Z478
    Secondary Accessions:
    • O75549
    • Q63HN0
    • Q63HN3
    • Q8IWW2
    • Q8N3A1
    • Q9UMH2

    Protein attributes for DHX29 Gene

    Size:
    1369 amino acids
    Molecular mass:
    155236 Da
    Quaternary structure:
    • Part of the 43S preinitiation complex that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit.

neXtProt entry for DHX29 Gene

Proteomics data for DHX29 Gene at MOPED

Selected DME Specific Peptides for DHX29 Gene

Post-translational modifications for DHX29 Gene

  • Ubiquitination at Lys494
  • Modification sites at PhosphoSitePlus

Other Protein References for DHX29 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DHX29 (DDX29)

Domains for DHX29 Gene

Gene Families for DHX29 Gene

HGNC:
  • DHX :DEAH-boxes

Suggested Antigen Peptide Sequences for DHX29 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z478

UniProtKB/Swiss-Prot:

DHX29_HUMAN :
  • Q7Z478
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX29: view

Function for DHX29 Gene

Molecular function for DHX29 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: ATP-binding RNA helicase involved in translation initiation. Part of the 43S preinitiation complex that is required for efficient initiation on mammalian mRNAs with structured 5-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.

Enzyme Numbers (IUBMB) for DHX29 Gene

Gene Ontology (GO) - Molecular Function for DHX29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003743 translation initiation factor activity IEA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DHX29: view

Phenotypes for DHX29 Gene

genes like me logo Genes that share phenotypes with DHX29: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DHX29

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DHX29 Gene

Localization for DHX29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX29 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHX29 Gene COMPARTMENTS Subcellular localization image for DHX29 gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for DHX29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005739 mitochondrion IBA --
GO:0016282 eukaryotic 43S preinitiation complex IDA 23706745
genes like me logo Genes that share ontologies with DHX29: view

Pathways for DHX29 Gene

genes like me logo Genes that share pathways with DHX29: view

Pathways by source for DHX29 Gene

2 Cell Signaling Technology pathways for DHX29 Gene

Gene Ontology (GO) - Biological Process for DHX29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006396 RNA processing IBA --
GO:0006413 translational initiation IEA --
genes like me logo Genes that share ontologies with DHX29: view

Transcripts for DHX29 Gene

Unigene Clusters for DHX29 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 29:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DHX29

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DHX29

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX29 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6: -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for DHX29 Gene

GeneLoc Exon Structure for
DHX29
ECgene alternative splicing isoforms for
DHX29

Expression for DHX29 Gene

mRNA expression in normal human tissues for DHX29 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHX29 Gene

SOURCE GeneReport for Unigene cluster for DHX29 Gene Hs.593268

genes like me logo Genes that share expressions with DHX29: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DHX29 Gene

Orthologs for DHX29 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX29 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHX29 35
  • 99.63 (n)
  • 99.56 (a)
DHX29 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DHX29 35
  • 92.38 (n)
  • 94.73 (a)
DHX29 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DHX29 35
  • 92.51 (n)
  • 95.1 (a)
DHX29 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dhx29 35
  • 84.97 (n)
  • 91.06 (a)
Dhx29 16
Dhx29 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DHX29 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100362324 35
  • 85.95 (n)
  • 90.91 (a)
chicken
(Gallus gallus)
Aves DHX29 35
  • 77.34 (n)
  • 80.79 (a)
DHX29 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHX29 36
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6004 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx29 35
  • 67.95 (n)
  • 71.82 (a)
Str.17378 35
zebrafish
(Danio rerio)
Actinopterygii DHX29 36
  • 62 (a)
OneToOne
Dr.9383 35
LOC553505 35
  • 61.43 (n)
  • 63.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8915 36
  • 29 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G58060 35
  • 49.94 (n)
  • 42.21 (a)
rice
(Oryza sativa)
Liliopsida Os04g0432300 35
  • 49.87 (n)
  • 41.34 (a)
Species with no ortholog for DHX29:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DHX29 Gene

ENSEMBL:
Gene Tree for DHX29 (if available)
TreeFam:
Gene Tree for DHX29 (if available)

Paralogs for DHX29 Gene

Paralogs for DHX29 Gene

Selected SIMAP similar genes for DHX29 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for DHX29 Gene

genes like me logo Genes that share paralogs with DHX29: view

Variants for DHX29 Gene

Sequence variations from dbSNP and Humsavar for DHX29 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs170779 -- 55,265,815(+) tctag(A/G)gggca intron-variant
rs186745 -- 55,266,057(+) tgcag(G/T)ggtgc intron-variant
rs191387 -- 55,265,225(+) agact(C/T)taatg intron-variant
rs231365 -- 55,261,318(+) TGGTA(C/T)TGGAA intron-variant
rs231366 -- 55,265,107(+) aaaaa(A/C)caaag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHX29 Gene

Variant ID Type Subtype PubMed ID
nsv830302 CNV Gain 17160897
dgv6070n71 CNV Loss 21882294
esv2730188 CNV Deletion 23290073
esv2730189 CNV Deletion 23290073
dgv6071n71 CNV Loss 21882294

Relevant External Links for DHX29 Gene

HapMap Linkage Disequilibrium report
DHX29

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX29 Gene

Disorders for DHX29 Gene

Relevant External Links for DHX29

Genetic Association Database (GAD)
DHX29
Human Genome Epidemiology (HuGE) Navigator
DHX29
genes like me logo Genes that share disorders with DHX29: view

No data available for UniProtKB/Swiss-Prot for DHX29 Gene

Publications for DHX29 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4
  3. Translation initiation on mammalian mRNAs with structured 5'UTRs requires DExH-box protein DHX29. (PMID: 19109895) Pisareva V.P. … Pestova T.V. (Cell 2008) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  5. Structure of the mammalian ribosomal 43S preinitiation complex bound to the scanning factor DHX29. (PMID: 23706745) Hashem Y. … Frank J. (Cell 2013) 3 4

Products for DHX29 Gene

Sources for DHX29 Gene

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