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Aliases for DHX29 Gene

Aliases for DHX29 Gene

  • DExH-Box Helicase 29 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 29 2 3
  • Nucleic Acid Helicase DDXx 3 4
  • DEAH-Box Helicase 29 2 3
  • DEAH Box Protein 29 3 4
  • DDX29 3 4
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 29 3
  • ATP-Dependent RNA Helicase DHX29 3
  • EC 3.6.4.13 4
  • EC 3.6.1 61

External Ids for DHX29 Gene

Previous HGNC Symbols for DHX29 Gene

  • DDX29

Previous GeneCards Identifiers for DHX29 Gene

  • GC05M054522
  • GC05M054567
  • GC05M054587
  • GC05M054552
  • GC05M051525

Summaries for DHX29 Gene

Entrez Gene Summary for DHX29 Gene

  • This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein functions in translation initiation, and is specifically required for ribosomal scanning across stable mRNA secondary structures during initiation codon selection. This protein may also play a role in sensing virally derived cytosolic nucleic acids. Knockdown of this gene results in reduced protein translation and impaired proliferation of cancer cells. [provided by RefSeq, Sep 2016]

GeneCards Summary for DHX29 Gene

DHX29 (DExH-Box Helicase 29) is a Protein Coding gene. Among its related pathways are Translational Control and Chromatin Regulation / Acetylation. GO annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DHX57.

UniProtKB/Swiss-Prot for DHX29 Gene

  • ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX29 Gene

Genomics for DHX29 Gene

Regulatory Elements for DHX29 Gene

Enhancers for DHX29 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G056167 1.8 FANTOM5 Ensembl ENCODE dbSUPER 68.7 -861.7 -861673 3.7 PKNOX1 ZNF493 ZFP64 ZNF121 GATA2 KLF7 FOS ZNF202 SP3 REST DHX29 RPL26P19 ENSG00000271828 RNF138P1 SLC38A9 ENSG00000264281 LOC100419851 ENSG00000238326 RNU6-299P FLJ31104
GH05G055463 1 FANTOM5 68.8 -156.4 -156382 0.3 ZNF493 ZFP64 ZNF155 ZNF121 ZNF23 ZNF138 ZNF354C KLF7 ZNF202 ZNF654 DHX29 RNF138P1 ENSG00000264281 LOC100419851 GPX8 SLC38A9 FLJ31104 ENSG00000279883 GC05M055421
GH05G056010 1.6 Ensembl ENCODE dbSUPER 15.6 -704.6 -704644 3.0 HDGF FOXA2 PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 FEZF1 ZNF2 DHX29 RPL26P19 ENSG00000264281 GPX8 ENSG00000271828 IL6ST ENSG00000238326 LOC105378976
GH05G054516 1.3 ENCODE dbSUPER 14.9 +788.0 787952 6.2 ARNT CREB3L1 AGO1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 ZNF207 DHX29 LOC100130990 SNX18 HSPB3 PIR32129 PIR52196
GH05G054387 1.2 Ensembl ENCODE 13.2 +919.5 919481 1.3 PKNOX1 ZSCAN4 INSM2 ZNF76 FEZF1 ZNF2 ZEB1 ZNF366 ZSCAN5C SCRT2 DHX29 LOC100419851 HSPB3 RPL37P25 LINC01033
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DHX29 on UCSC Golden Path with GeneCards custom track

Promoters for DHX29 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000180740 -178 3001 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for DHX29 Gene

Chromosome:
5
Start:
55,256,245 bp from pter
End:
55,307,722 bp from pter
Size:
51,478 bases
Orientation:
Minus strand

Genomic View for DHX29 Gene

Genes around DHX29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX29 Gene

Proteins for DHX29 Gene

  • Protein details for DHX29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z478-DHX29_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DHX29
    Protein Accession:
    Q7Z478
    Secondary Accessions:
    • O75549
    • Q63HN0
    • Q63HN3
    • Q8IWW2
    • Q8N3A1
    • Q9UMH2

    Protein attributes for DHX29 Gene

    Size:
    1369 amino acids
    Molecular mass:
    155236 Da
    Quaternary structure:
    • Part of the 43S pre-initiation complex (PIC) that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit.

neXtProt entry for DHX29 Gene

Selected DME Specific Peptides for DHX29 Gene

Q7Z478:
  • GAVLIFLPG
  • VLATNIAET
  • VDEVHER
  • GVLLRKL
  • TQPRRISA

Post-translational modifications for DHX29 Gene

  • Ubiquitination at Lys494
  • Modification sites at PhosphoSitePlus

Other Protein References for DHX29 Gene

Domains & Families for DHX29 Gene

Gene Families for DHX29 Gene

Suggested Antigen Peptide Sequences for DHX29 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z478

UniProtKB/Swiss-Prot:

DHX29_HUMAN :
  • Belongs to the DEAD box helicase family. DEAH subfamily.
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX29: view

Function for DHX29 Gene

Molecular function for DHX29 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.

Enzyme Numbers (IUBMB) for DHX29 Gene

Gene Ontology (GO) - Molecular Function for DHX29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA 22681889
GO:0003743 translation initiation factor activity IEA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
genes like me logo Genes that share ontologies with DHX29: view
genes like me logo Genes that share phenotypes with DHX29: view

Animal Models for DHX29 Gene

MGI Knock Outs for DHX29:

Animal Model Products

  • Taconic Biosciences Mouse Models for DHX29

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DHX29 Gene

Localization for DHX29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX29 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHX29 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for DHX29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA,IBA --
GO:0016282 eukaryotic 43S preinitiation complex IDA 23706745
genes like me logo Genes that share ontologies with DHX29: view

Pathways & Interactions for DHX29 Gene

genes like me logo Genes that share pathways with DHX29: view

Pathways by source for DHX29 Gene

2 Cell Signaling Technology pathways for DHX29 Gene

Gene Ontology (GO) - Biological Process for DHX29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IBA --
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA --
genes like me logo Genes that share ontologies with DHX29: view

No data available for SIGNOR curated interactions for DHX29 Gene

Drugs & Compounds for DHX29 Gene

(3) Drugs for DHX29 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for DHX29 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DHX29: view

Transcripts for DHX29 Gene

Unigene Clusters for DHX29 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 29:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX29 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6: -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for DHX29 Gene

GeneLoc Exon Structure for
DHX29
ECgene alternative splicing isoforms for
DHX29

Expression for DHX29 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHX29 Gene

Protein differential expression in normal tissues from HIPED for DHX29 Gene

This gene is overexpressed in Milk (13.0) and Peripheral blood mononuclear cells (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DHX29 Gene



Protein tissue co-expression partners for DHX29 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DHX29 Gene:

DHX29

SOURCE GeneReport for Unigene cluster for DHX29 Gene:

Hs.593268

Evidence on tissue expression from TISSUES for DHX29 Gene

  • Nervous system(4.7)
  • Liver(4.3)
  • Lung(3.6)
  • Intestine(2.9)
  • Kidney(2.5)
genes like me logo Genes that share expression patterns with DHX29: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHX29 Gene

Orthologs for DHX29 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX29 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHX29 34 35
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia DHX29 34 35
  • 92.51 (n)
cow
(Bos Taurus)
Mammalia DHX29 34 35
  • 92.38 (n)
oppossum
(Monodelphis domestica)
Mammalia DHX29 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 88 (a)
OneToMany
-- 35
  • 82 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100362324 34
  • 85.95 (n)
mouse
(Mus musculus)
Mammalia Dhx29 34 16 35
  • 84.97 (n)
chicken
(Gallus gallus)
Aves DHX29 34 35
  • 77.34 (n)
lizard
(Anolis carolinensis)
Reptilia DHX29 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx29 34
  • 67.95 (n)
Str.17378 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6004 34
zebrafish
(Danio rerio)
Actinopterygii DHX29 35
  • 62 (a)
OneToOne
LOC553505 34
  • 61.43 (n)
Dr.9383 34
fruit fly
(Drosophila melanogaster)
Insecta CG8915 35
  • 29 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G58060 34
  • 49.94 (n)
rice
(Oryza sativa)
Liliopsida Os04g0432300 34
  • 49.87 (n)
Species where no ortholog for DHX29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DHX29 Gene

ENSEMBL:
Gene Tree for DHX29 (if available)
TreeFam:
Gene Tree for DHX29 (if available)

Paralogs for DHX29 Gene

Paralogs for DHX29 Gene

(4) SIMAP similar genes for DHX29 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for DHX29 Gene

genes like me logo Genes that share paralogs with DHX29: view

Variants for DHX29 Gene

Sequence variations from dbSNP and Humsavar for DHX29 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs193920824 Uncertain significance 55,290,250(-) AAAAG(A/T)GGCTC intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime
rs1000010383 -- 55,256,976(+) AGCAA(G/T)GAAGA intron-variant
rs1000022515 -- 55,290,773(+) ACTTT(A/G)GGAGG intron-variant
rs1000023832 -- 55,295,149(+) GCTGA(A/G)CCCAG intron-variant, nc-transcript-variant
rs1000026456 -- 55,256,627(+) ATATG(C/T)CACTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHX29 Gene

Variant ID Type Subtype PubMed ID
esv2730188 CNV deletion 23290073
esv2730189 CNV deletion 23290073
nsv1027090 CNV gain 25217958
nsv598180 CNV gain 21841781
nsv830302 CNV gain 17160897

Variation tolerance for DHX29 Gene

Residual Variation Intolerance Score: 7.68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.75; 66.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHX29 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DHX29

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX29 Gene

Disorders for DHX29 Gene

Relevant External Links for DHX29

Genetic Association Database (GAD)
DHX29
Human Genome Epidemiology (HuGE) Navigator
DHX29
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHX29

No disorders were found for DHX29 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX29 Gene

Publications for DHX29 Gene

  1. Structure of the mammalian ribosomal 43S preinitiation complex bound to the scanning factor DHX29. (PMID: 23706745) Hashem Y. … Frank J. (Cell 2013) 3 4 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. Translation initiation on mammalian mRNAs with structured 5'UTRs requires DExH-box protein DHX29. (PMID: 19109895) Pisareva V.P. … Pestova T.V. (Cell 2008) 3 4 64
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for DHX29 Gene

Sources for DHX29 Gene

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