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Aliases for DHX29 Gene

Aliases for DHX29 Gene

  • DEAH-Box Helicase 29 2 3
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 29 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 29 2 3
  • Nucleic Acid Helicase DDXx 3 4
  • DEAH Box Protein 29 3 4
  • DDX29 3 4
  • EC 3.6.4.13 4
  • EC 3.6.1 63

External Ids for DHX29 Gene

Previous HGNC Symbols for DHX29 Gene

  • DDX29

Previous GeneCards Identifiers for DHX29 Gene

  • GC05M054522
  • GC05M054567
  • GC05M054587
  • GC05M054552
  • GC05M051525

Summaries for DHX29 Gene

GeneCards Summary for DHX29 Gene

DHX29 (DEAH-Box Helicase 29) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DHX36.

UniProtKB/Swiss-Prot for DHX29 Gene

  • ATP-binding RNA helicase involved in translation initiation. Part of the 43S preinitiation complex that is required for efficient initiation on mammalian mRNAs with structured 5-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX29 Gene

Genomics for DHX29 Gene

Regulatory Elements for DHX29 Gene

Promoters for DHX29 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DHX29 on UCSC Golden Path with GeneCards custom track

Genomic Location for DHX29 Gene

Chromosome:
5
Start:
55,256,245 bp from pter
End:
55,307,722 bp from pter
Size:
51,478 bases
Orientation:
Minus strand

Genomic View for DHX29 Gene

Genes around DHX29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX29 Gene

Proteins for DHX29 Gene

  • Protein details for DHX29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z478-DHX29_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DHX29
    Protein Accession:
    Q7Z478
    Secondary Accessions:
    • O75549
    • Q63HN0
    • Q63HN3
    • Q8IWW2
    • Q8N3A1
    • Q9UMH2

    Protein attributes for DHX29 Gene

    Size:
    1369 amino acids
    Molecular mass:
    155236 Da
    Quaternary structure:
    • Part of the 43S preinitiation complex that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit.

neXtProt entry for DHX29 Gene

Proteomics data for DHX29 Gene at MOPED

Selected DME Specific Peptides for DHX29 Gene

Post-translational modifications for DHX29 Gene

  • Ubiquitination at Lys 494
  • Modification sites at PhosphoSitePlus

Other Protein References for DHX29 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DHX29 (DDX29)

Domains & Families for DHX29 Gene

Gene Families for DHX29 Gene

Suggested Antigen Peptide Sequences for DHX29 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z478

UniProtKB/Swiss-Prot:

DHX29_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DEAH subfamily.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX29: view

Function for DHX29 Gene

Molecular function for DHX29 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
ATP-binding RNA helicase involved in translation initiation. Part of the 43S preinitiation complex that is required for efficient initiation on mammalian mRNAs with structured 5-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.

Enzyme Numbers (IUBMB) for DHX29 Gene

Gene Ontology (GO) - Molecular Function for DHX29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0008026 ATP-dependent helicase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with DHX29: view
genes like me logo Genes that share phenotypes with DHX29: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DHX29

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DHX29 Gene

Localization for DHX29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX29 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHX29 Gene COMPARTMENTS Subcellular localization image for DHX29 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for DHX29 Gene

Pathways & Interactions for DHX29 Gene

SuperPathways for DHX29 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHX29 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DHX29 Gene

Drugs & Compounds for DHX29 Gene

(1) Drugs for DHX29 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DHX29 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DHX29: view

Transcripts for DHX29 Gene

Unigene Clusters for DHX29 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 29:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHX29 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6: -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for DHX29 Gene

GeneLoc Exon Structure for
DHX29
ECgene alternative splicing isoforms for
DHX29

Expression for DHX29 Gene

mRNA expression in normal human tissues for DHX29 Gene

Protein differential expression in normal tissues from HIPED for DHX29 Gene

This gene is overexpressed in Milk (13.0) and Peripheral blood mononuclear cells (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHX29 Gene



SOURCE GeneReport for Unigene cluster for DHX29 Gene Hs.593268

genes like me logo Genes that share expression patterns with DHX29: view

Protein tissue co-expression partners for DHX29 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DHX29 Gene

Orthologs for DHX29 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX29 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DHX29 35
  • 92.38 (n)
  • 94.73 (a)
DHX29 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DHX29 35
  • 92.51 (n)
  • 95.1 (a)
DHX29 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dhx29 35
  • 84.97 (n)
  • 91.06 (a)
Dhx29 16
Dhx29 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DHX29 35
  • 99.63 (n)
  • 99.56 (a)
DHX29 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100362324 35
  • 85.95 (n)
  • 90.91 (a)
oppossum
(Monodelphis domestica)
Mammalia DHX29 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
chicken
(Gallus gallus)
Aves DHX29 35
  • 77.34 (n)
  • 80.79 (a)
DHX29 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHX29 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx29 35
  • 67.95 (n)
  • 71.82 (a)
Str.17378 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6004 35
zebrafish
(Danio rerio)
Actinopterygii Dr.9383 35
LOC553505 35
  • 61.43 (n)
  • 63.83 (a)
DHX29 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8915 36
  • 29 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G58060 35
  • 49.94 (n)
  • 42.21 (a)
rice
(Oryza sativa)
Liliopsida Os04g0432300 35
  • 49.87 (n)
  • 41.34 (a)
Species with no ortholog for DHX29:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DHX29 Gene

ENSEMBL:
Gene Tree for DHX29 (if available)
TreeFam:
Gene Tree for DHX29 (if available)

Paralogs for DHX29 Gene

Paralogs for DHX29 Gene

(4) SIMAP similar genes for DHX29 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for DHX29 Gene

genes like me logo Genes that share paralogs with DHX29: view

Variants for DHX29 Gene

Sequence variations from dbSNP and Humsavar for DHX29 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_026985 -
VAR_052180 -
rs186745 -- 55,266,057(+) tgcag(G/T)ggtgc intron-variant
rs170779 -- 55,265,815(+) tctag(A/G)gggca intron-variant
rs191387 -- 55,265,225(+) agact(C/T)taatg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHX29 Gene

Variant ID Type Subtype PubMed ID
nsv830302 CNV Gain 17160897
dgv6070n71 CNV Loss 21882294
esv2730188 CNV Deletion 23290073
esv2730189 CNV Deletion 23290073
dgv6071n71 CNV Loss 21882294

Variation tolerance for DHX29 Gene

Residual Variation Intolerance Score: 7.68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.75; 66.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHX29 Gene

HapMap Linkage Disequilibrium report
DHX29

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX29 Gene

Disorders for DHX29 Gene

Relevant External Links for DHX29

Genetic Association Database (GAD)
DHX29
Human Genome Epidemiology (HuGE) Navigator
DHX29
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHX29

No disorders were found for DHX29 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX29 Gene

Publications for DHX29 Gene

  1. Structure of the mammalian ribosomal 43S preinitiation complex bound to the scanning factor DHX29. (PMID: 23706745) Hashem Y. … Frank J. (Cell 2013) 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Helicase proteins DHX29 and RIG-I cosense cytosolic nucleic acids in the human airway system. (PMID: 24821782) Sugimoto N. … Liu Y.J. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. (PMID: 22681889) Baltz A.G. … Landthaler M. (Mol. Cell 2012) 3

Products for DHX29 Gene

Sources for DHX29 Gene

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