Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DHX29 Gene

protein-coding   GIFtS: 54
GCID: GC05M054552

DEAH (Asp-Glu-Ala-His) Box Polypeptide 29

(Previous name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 29)
(Previous symbol: DDX29)
  Search for DHX29
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
DEAH (Asp-Glu-Ala-His) Box Polypeptide 291 2     DEAH Box Protein 292 3
DDX291 2 3     ATP-Dependent RNA Helicase DHX292
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 291 2     EC 3.6.4.133
Nucleic Acid Helicase DDXx2 3     EC 3.6.18

External Ids:    HGNC: 158151   Entrez Gene: 545052   Ensembl: ENSG000000672487   OMIM: 6127205   UniProtKB: Q7Z4783   

Export aliases for DHX29 gene to outside databases

Previous GC identifers: GC05M054522 GC05M054567 GC05M054587 GC05M051525


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for DHX29 Gene:
DHX29 (DEAH (Asp-Glu-Ala-His) box polypeptide 29) is a protein-coding gene. GO annotations related to this gene include ribosomal small subunit binding and ATP-dependent helicase activity. An important paralog of this gene is DHX30.

UniProtKB/Swiss-Prot: DHX29_HUMAN, Q7Z478
Function: ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that
is required for efficient initiation on mammalian mRNAs with structured 5'-UTRs by promoting efficient
NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not
possess a processive helicase activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DHX29 gene promoter:
         ATF-2   CUTL1   CRE-BP1   RORalpha1   FOXC1   E2F   E2F-1   NF-kappaB1   Pax-4a   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDHX29 promoter sequence
   Search Chromatin IP Primers for DHX29

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DHX29


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q11.2

DHX29 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHX29 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M054552:  view genomic region     (about GC identifiers)

Start:
54,552,073 bp from pter      End:
54,603,550 bp from pter
Size:
51,478 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DHX29_HUMAN, Q7Z478 (See protein sequence)
Recommended Name: ATP-dependent RNA helicase DHX29  
Size: 1369 amino acids; 155236 Da
Subunit: Part of the 43S pre-initiation complex that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY),
EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L,
EIF3M, DHX29 and the 40S ribosomal subunit
Secondary accessions: O75549 Q63HN0 Q63HN3 Q8IWW2 Q8N3A1 Q9UMH2

Explore the universe of human proteins at neXtProt for DHX29: NX_Q7Z478

Explore proteomics data for DHX29 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys494
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DHX29 (Q7Z478) (see all 5)
     VDEVHER  GVLLRKL  TQPRRISA  VLATNIAET 


    See DHX29 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061903.2  
    ENSEMBL proteins: 
     ENSP00000251636   ENSP00000421435  

    DHX29 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DHX29
    OriGene Protein Over-expression Lysate for DHX29
    OriGene MassSpec for DHX29
    OriGene Custom Protein Services for DHX29
    GenScript Custom Purified and Recombinant Proteins Services for DHX29
    Novus Biologicals DHX29 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DHX29

     
    Search eBioscience for Proteins for DHX29 

    DHX29 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for DHX29  (DDX29)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DHX29
    Novus Biologicals DHX29 Antibodies
    Abcam antibodies for DHX29
    Cloud-Clone Corp. Antibodies for DHX29
    Search ThermoFisher Antibodies for DHX29
    LSBio Antibodies in human, mouse, rat for DHX29

    DHX29 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DHX29
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DHX29
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DHX29
    Cloud-Clone Corp. CLIAs for DHX29
    Search eBioscience for ELISAs for DHX29 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    DHX: DEAH-boxes

    Selected InterPro protein domains (see all 7):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR002464 DNA/RNA_helicase_DEAH_CS
     IPR007502 Helicase-assoc_dom
     IPR011709 DUF1605
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q7Z478

    ProtoNet protein and cluster: Q7Z478

    2 Blocks protein domains:
    IPB002464 ATP-dependent helicase
    IPB007502 Helicase-associated region


    UniProtKB/Swiss-Prot: DHX29_HUMAN, Q7Z478
    Similarity: Belongs to the DEAD box helicase family. DEAH subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Find genes that share domains with DHX29           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DHX29_HUMAN, Q7Z478
    Function: ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that
    is required for efficient initiation on mammalian mRNAs with structured 5'-UTRs by promoting efficient
    NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not
    possess a processive helicase activity
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003743translation initiation factor activity IEA--
    GO:0004386helicase activity ----
    GO:0005524ATP binding IEA--
    GO:0008026ATP-dependent helicase activity IEA--
         
    Find genes that share ontologies with DHX29           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DHX29:
     Decreased circadian period len  Synthetic lethal with c-Myc af 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Dhx29):
     mortality/aging 

    Find genes that share phenotypes with DHX29           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dhx29tm1(KOMP)Vlcg for DHX29

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DHX29
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DHX29

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DHX29
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DHX29

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat DHX29 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate DHX29
    SwitchGear 3'UTR luciferase reporter plasmidDHX29 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DHX29
    Predesigned siRNA for gene silencing in human, mouse, rat DHX29

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DHX29

    Clone
    Products:
         
    OriGene clones in human, mouse for DHX29 (see all 7)
    OriGene ORF clones in mouse, rat for DHX29
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DHX29 (NM_019030)
    Sino Biological Human cDNA Clone for DHX29
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHX29
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX29

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DHX29
    Browse ESI BIO Cell Lines and PureStem Progenitors for DHX29 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX29


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DHX29_HUMAN, Q7Z478: Cytoplasm (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    mitochondrion2
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0016282eukaryotic 43S preinitiation complex IDA--

    Find genes that share ontologies with DHX29           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for DHX29 About    
    See pathways by source

    SuperPathContained pathways About
    1Translational Control
    Translational Control
    2Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation


    Find genes that share SuperPaths with DHX29           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for DHX29
        Chromatin Regulation / Acetylation
    Translational Control



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DHX29
    Interactions:

        Search GeneGlobe Interaction Network for DHX29

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DHX29 (Q7Z4782, 3 ENSP000002516364) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CENPTQ96BT32, 3MINT-65178 I2D: score=5 
    TBC1D17Q9HA652, 3, ENSP000002215434MINT-64771 I2D: score=3 STRING: ENSP00000221543
    PISDQ9UG563, ENSP000002660954I2D: score=3 STRING: ENSP00000266095
    CCT4P509913I2D: score=1 
    CNBPP626333I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DHX29



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DHX29 gene: 
    NM_019030.2  

    Unigene Cluster for DHX29:

    DEAH (Asp-Glu-Ala-His) box polypeptide 29
    Hs.593268  [show with all ESTs]
    Unigene Representative Sequence: BX649135
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000251636(uc003jpx.3) ENST00000504778(uc010ivw.3) ENST00000513447
    ENST00000508346
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DHX29 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate DHX29
    SwitchGear 3'UTR luciferase reporter plasmidDHX29 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DHX29
    Predesigned siRNA for gene silencing in human, mouse, rat DHX29
    Clone
    Products:
         
    OriGene clones in human, mouse for DHX29 (see all 7)
    OriGene ORF clones in mouse, rat for DHX29
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DHX29 (NM_019030)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHX29
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX29
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DHX29
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DHX29
      QuantiTect SYBR Green Assays in human, mouse, rat DHX29
      QuantiFast Probe-based Assays in human, mouse, rat DHX29

    Additional mRNA sequence: 

    AF070639.1 AK025145.1 AK308332.1 AL079292.1 AL834496.1 AY036974.1 BC035988.1 BC056219.1 
    BX648101.1 BX648269.1 BX648688.1 BX649135.1 

    15 DOTS entries:

    DT.95269800  DT.455425  DT.99939840  DT.91752294  DT.97762127  DT.102830587  DT.410594  DT.92421350 
    DT.100000262  DT.75103821  DT.95269798  DT.95372796  DT.100700734  DT.404426  DT.91750641 

    Selected AceView cDNA sequences (see all 180):

    BX649135 BU159983 BQ002888 BE501386 AL834496 BX648688 AW264061 AL600554 
    BM834507 BC056219 BM711224 BQ045394 CB243050 AW136162 AI097380 R31854 
    BX282439 BU517211 BQ271507 BQ716293 AA489622 AI081302 BM666203 CK822641 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DHX29 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
    SP1:                                                                                                                    -                                       
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for DHX29

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DHX29 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATAATTTTC
    DHX29 Expression
    About this image

    DHX29 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DHX29 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.593268
        Custom PCR Arrays for DHX29
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for DHX29
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DHX29
    QuantiTect SYBR Green Assays in human, mouse, rat DHX29
    QuantiFast Probe-based Assays in human, mouse, rat DHX29
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX29

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DHX29 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dhx291 , 5 DEAH (Asp-Glu-Ala-His) box polypeptide 291, 5 84.97(n)1
    91.06(a)1
      13 (63.93 cM)5
    2186291  NM_172594.21  NP_766182.21 
     1129277935 
    chicken
    (Gallus gallus)
    Aves DHX291 DEAH (Asp-Glu-Ala-His) box polypeptide 29 77.34(n)
    80.79(a)
      427136  XM_424728.4  XP_424728.3 
    lizard
    (Anolis carolinensis)
    Reptilia DHX296
    DEAH (Asp-Glu-Ala-His) box polypeptide 29
    78(a)
    1 ↔ 1
    2(2574589-2602425)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.60042 Xenopus laevis transcribed sequence with weak similarity more 73.96(n)    BJ073411.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.93832 Transcribed sequence with weak similarity to protein more 73.34(n)    BI885341.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG89156
    --
    29(a)
    1 ↔ 1
    X(17135300-17139045)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G580601 AT1G58060 49.94(n)
    42.21(a)
      842173  NM_104588.3  NP_176103.2 
    rice
    (Oryza sativa)
    Liliopsida Os04g04323001 Os04g0432300 49.87(n)
    41.34(a)
      9267691  NM_001187018.1  NP_001173947.1 


    ENSEMBL Gene Tree for DHX29 (if available)
    TreeFam Gene Tree for DHX29 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DHX29 gene
    DHX302  DHX362  TDRD92  YTHDC22  DHX572  DHX92  
    4 SIMAP similar genes for DHX29 using alignment to 2 protein entries:     DHX29_HUMAN (see all proteins):
    DHX36    DHX57    DKFZp762F2011    HIG-1

    Find genes that share paralogs with DHX29           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for DHX29
    PGOHUM00000244377


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DHX29 (see all 982)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1917397261,2
    --54551586(+) TAGGAC/TCAATG 1 -- ds50010--------
    rs1507985741,2
    C--54551603(+) ACCTAC/TGCATA 1 -- ds50010--------
    rs1831452471,2
    --54551616(+) TTACTA/GTCTCA 1 -- ds50010--------
    rs1878464851,2
    --54551648(+) CAATCA/GCGTAT 1 -- ds50010--------
    rs765299781,2
    F--54551728(+) AAGGCA/C/TGACAG 1 -- ds50011NA 2
    rs32176671,2
    C--54551774(+) ACCAC-/ATGTTTA 1 -- ds50010--------
    rs1833913401,2
    C--54551913(+) AATTGA/GTTTTG 1 -- ds50010--------
    rs353075291,2
    C,F,H--54552059(+) CACAAC/TGATGA 1 -- ds500119Minor allele frequency- T:0.10NS EA NA CSA WA 2346
    rs1877265891,2
    --54552186(+) CCCACC/TACCTT 1 -- ut310--------
    rs1923901941,2
    C--54552279(+) CTTCAC/TCTTAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DHX29 (54552073 - 54603550 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for DHX29:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730188CNV Deletion23290073
    esv2730189CNV Deletion23290073
    dgv6070n71CNV Loss21882294
    dgv6071n71CNV Loss21882294
    nsv830302CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DHX29
    DNA2.0 Custom Variant and Variant Library Synthesis for DHX29

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612720    OMIM disorders: --


    Find genes that share disorders with DHX29           About GenesLikeMe

    Genetic Association Database (GAD): DHX29
    Human Genome Epidemiology (HuGE) Navigator: DHX29 (1 document)

    Export disorders for DHX29 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DHX29 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with DHX29)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    2. Translation initiation on mammalian mRNAs with structured 5'UTRs requires DExH-box protein DHX29. (PubMed id 19109895)1, 2 Pisareva V.P.... Pestova T.V. (Cell 2008)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Structure of the mammalian ribosomal 43S preinitiation complex bound to the scanning factor DHX29. (PubMed id 23706745)2 Hashem Y.... Frank J. (Cell 2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Roles of individual domains in the function of DHX29, an essential factor required for translation of structured mammalian mRNAs. (PubMed id 23047696)1 Dhote V....Pestova T.V. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 54505 HGNC: 15815 AceView: DHX29 Ensembl:ENSG00000067248 euGenes: HUgn54505
    ECgene: DHX29 H-InvDB: DHX29

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DHX29 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DHX29 gene:
    Search GeneIP for patents involving DHX29

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DHX29  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for DHX29  
     OriGene MassSpec something-or-other for DHX29   OriGene clones in human, mouse for DHX29  
     OriGene qSTAR qPCR primer pairs in human, mouse for DHX29   OriGene Purified Protein for DHX29  
     OriGene ORF clones in mouse, rat for DHX29   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DHX29   OriGene Custom Protein Services for DHX29  

     
     
     Block miRNA regulation of human, mouse, rat DHX29 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DHX29
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DHX29 Predesigned siRNA for gene silencing in human, mouse, rat DHX29
     QuantiFast Probe-based Assays in human, mouse, rat DHX29 QuantiTect SYBR Green Assays in human, mouse, rat DHX29
     Custom PCR Arrays for DHX29 Search Chromatin IP Primers for DHX29
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DHX29  Search GeneGlobe Interaction Network for DHX29
     Regulatory tfbs in DHX29 promoter
     GenScript Custom Purified and Recombinant Proteins Services for DHX29 GenScript cDNA clones with any tag delivered in your preferred vector for DHX29
     GenScript Custom Assay Services for DHX29 GenScript Custom overexpressing Cell Line Services for DHX29
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for DHX29  (DDX29)

     Search Tocris compounds for DHX29
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for DHX29
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DHX29 antibodies
     DHX29 lysates
     Antibodies for DHX29
     See all of Abcam's Antibodies, Kits and Proteins for DHX29
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for DHX29
     Antibodies for DHX29
     ELISAs for DHX29
     CLIAs for DHX29



     Browse ESI BIO Cell Lines and PureStem Progenitors for DHX29
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX29
     SwitchGear 3'UTR luciferase reporter plasmids for DHX29
     SwitchGear Promoter luciferase reporter plasmids for DHX29
     Search ThermoFisher Antibodies for DHX29
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX29
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DHX29
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DHX29
     LSBio Antibodies in human, mouse, rat for DHX29
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for DHX29
      Search eBioscience for proteins for DHX29
      Search eBioscience for elisas for DHX29
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DHX29 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4