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DHX16 Gene

protein-coding   GIFtS: 63
GCID: GC06M030620

DEAH (Asp-Glu-Ala-His) Box Polypeptide 16

(Previous name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 16)
(Previous symbol: DDX16)
  Search for DHX16
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEAH (Asp-Glu-Ala-His) Box Polypeptide 161 2     PRPF22
DDX161 2 3 5     Prp22
DBP22 3 5     DEAD/H Box 162
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 161 2     Putative Pre-MRNA-Splicing Factor ATP-Dependent RNA Helicase DHX162
ATP-Dependent RNA Helicase #32 3     RNA Helicase2
DEAH-Box Protein 162 3     EC 3.6.4.133
PRP82 5     KIAA05773
PRO20142     EC 3.6.18

External Ids:    HGNC: 27391   Entrez Gene: 84492   Ensembl: ENSG000002045607   OMIM: 6034055   UniProtKB: O602313   

Export aliases for DHX16 gene to outside databases

Previous GC identifers: GC06M030391 GC06M030727 GC06M030728


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DHX16 Gene:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They
are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their
distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis,
and cellular growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission
yeast Prp8 protein involved in cell cycle progression. This gene is mapped to the MHC region on chromosome
6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked. Two transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Aug 2009)

GeneCards Summary for DHX16 Gene:
DHX16 (DEAH (Asp-Glu-Ala-His) box polypeptide 16) is a protein-coding gene. GO annotations related to this gene include RNA helicase activity and nucleic acid binding. An important paralog of this gene is DHX33.

UniProtKB/Swiss-Prot: DHX16_HUMAN, O60231
Function: Probable ATP-binding RNA helicase involved in pre-mRNA splicing

Gene Wiki entry for DHX16 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  NT_113891.3  NT_167244.2  NT_167245.2  NT_167246.2  NT_167247.2  
NT_167248.2  NT_167249.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DHX16 gene promoter:
         TBP   AML1a   NF-kappaB   E47   Max   NF-kappaB2   ARP-1   Hand1   NF-kappaB1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DHX16 promoter sequence
   Search Chromatin IP Primers for DHX16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DHX16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

DHX16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHX16 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M030620:  view genomic region     (about GC identifiers)

Start:
30,620,896 bp from pter      End:
30,640,830 bp from pter
Size:
19,935 bases      Orientation:
minus strand

Selected alternative locations (see all 7):
Chr6-,NT_167249 1,953,168-1,973,134      Chr6-,NT_113891.2 2,132,939-2,152,903      Chr6-,NT_167246 1,968,963-1,988,926     
Chr6-,NT_167247 2,002,754-2,022,715      Chr6-,NT_167245 1,914,527-1,934,492      Chr6-,NT_167248 1,913,797-1,933,762     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DHX16_HUMAN, O60231 (See protein sequence)
Recommended Name: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16  
Size: 1041 amino acids; 119264 Da
Sequence caution: Sequence=BAA25503.2; Type=Erroneous initiation;
Secondary accessions: O60322 Q5JP45 Q969X7 Q96QC1

Explore the universe of human proteins at neXtProt for DHX16: NX_O60231

Explore proteomics data for DHX16 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys716
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DHX16 (O60231) (see all 16)
     TNIAETS  VGYSIRF  FLTGQEE  TVPEIQR 


    See DHX16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001157711.1  NP_003578.2  

    ENSEMBL proteins: 
     ENSP00000365620   ENSP00000365625   ENSP00000399101  

    DHX16 Human Recombinant Protein Products:

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    Novus Biologicals DHX16 Lysates
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    Cloud-Clone Corp. Proteins for DHX16

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DHX: DEAH-boxes

    Selected InterPro protein domains (see all 7):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR002464 DNA/RNA_helicase_DEAH_CS
     IPR007502 Helicase-assoc_dom
     IPR011709 DUF1605
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry O60231

    ProtoNet protein and cluster: O60231

    2 Blocks protein domains:
    IPB002464 ATP-dependent helicase
    IPB007502 Helicase-associated region


    UniProtKB/Swiss-Prot: DHX16_HUMAN, O60231
    Similarity: Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Find genes that share domains with DHX16           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DHX16_HUMAN, O60231
    Function: Probable ATP-binding RNA helicase involved in pre-mRNA splicing
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003724RNA helicase activity TAS9547260
    GO:0004386helicase activity ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with DHX16           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DHX16
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DHX16

    miRNA
    Products:
        
    miRTarBase miRNAs that target DHX16:
    hsa-mir-92a-3p (MIRT049188), hsa-mir-107 (MIRT048294), hsa-let-7b-5p (MIRT032275)

    Block miRNA regulation of human, mouse, rat DHX16 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate DHX16:
    hsa-miR-188-3p hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidDHX16 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DHX16
    Predesigned siRNA for gene silencing in human, mouse, rat DHX16

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): DHX16 (NM_001164239)
    Sino Biological Human cDNA Clone for DHX16
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX16

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    Browse ESI BIO Cell Lines and PureStem Progenitors for DHX16 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX16


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DHX16_HUMAN, O60231: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with DHX16           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DHX16 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA processing0.44
    2Spliceosome
    Spliceosome


    Find genes that share SuperPaths with DHX16           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for DHX16
        mRNA processing



    1 Kegg Pathway  (Kegg details for DHX16):
        Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DHX16
    Interactions:

        Search GeneGlobe Interaction Network for DHX16

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DHX16 (O602311, 2, 3 ENSP000003656254) via UniProtKB, MINT, STRING, and/or I2D (see all 111)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DHX38Q926201, 2, 3EBI-311446,EBI-1043041 MINT-8331635 MINT-8337640 I2D: score=1 
    GPKOWQ929171, 2EBI-311446,EBI-746309 MINT-8337662 MINT-8331646
    SF3B2Q134351, 2EBI-311446,EBI-749111 MINT-8332361 MINT-8333614
    XAB2Q9HCS71, 2EBI-311446,EBI-295232 MINT-8331624 MINT-8337090
    COILP384322, 3, ENSP000002403164MINT-2865160 I2D: score=3 STRING: ENSP00000240316
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--

    Find genes that share ontologies with DHX16           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DHX16

    1 HMDB Compound for DHX16    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DHX16 gene (2 alternative transcripts): 
    NM_001164239.1  NM_003587.4  

    Unigene Cluster for DHX16:

    DEAH (Asp-Glu-Ala-His) box polypeptide 16
    Hs.485060  [show with all ESTs]
    Unigene Representative Sequence: NM_003587
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376437(uc003nqy.3) ENST00000376442(uc011dmo.2 uc003nqz.3)
    ENST00000480966 ENST00000415603
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DHX16 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate DHX16:
    hsa-miR-188-3p hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidDHX16 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DHX16
    Predesigned siRNA for gene silencing in human, mouse, rat DHX16
    Clone
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    OriGene ORF clones in mouse, rat for DHX16
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DHX16 (NM_001164239)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHX16
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX16
    Primer
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    OriGene qPCR primer pairs and template standards for DHX16
    OriGene qSTAR qPCR primer pairs in human, mouse for DHX16
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DHX16
      QuantiTect SYBR Green Assays in human, mouse, rat DHX16
      QuantiFast Probe-based Assays in human, mouse, rat DHX16

    Additional mRNA sequence: 

    AB001601.1 AF119860.1 AK302721.1 AK312264.1 BC002789.2 BC008825.2 BC009392.2 

    15 DOTS entries:

    DT.97860002  DT.100787658  DT.91998700  DT.121360219  DT.40130931  DT.100030798  DT.100786921  DT.97860004 
    DT.100786930  DT.97860003  DT.91901099  DT.121360333  DT.100650943  DT.100733165  DT.95226768 

    19 AceView cDNA sequences:

    AF119860 BC008825 BC009392 BC002789 CR591941 BQ311555 AB001601 NM_003587 
    BG315341 BE839261 AA492431 BQ333691 BQ292037 AW610220 BE708164 AB011149 
    BF375726 BQ311619 BQ315816 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DHX16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAAGAAAAT
    DHX16 Expression
    About this image

    DHX16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DHX16 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.485060
        Custom PCR Arrays for DHX16
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DHX16 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dhx161 , 5 DEAH (Asp-Glu-Ala-His) box polypeptide 161, 5 87.24(n)1
    94.9(a)1
      17 (18.74 cM)5
    691921  NM_026987.21  NP_081263.21 
     358798195 
    lizard
    (Anolis carolinensis)
    Reptilia DHX166
    DEAH (Asp-Glu-Ala-His) box polypeptide 16
    75(a)
    1 ↔ 1
    2(192116099-192148981)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.37512 Xenopus laevis transcribed sequence with moderate similarity more 74.36(n)    BJ072880.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa91b122 wufa91b12 76.27(n)   336645  BC045393.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(2)37Cb1 lethal (2) 37Cb 66.09(n)
    67.24(a)
      35192  NM_136102.4  NP_609946.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mog-41 mog-4 59.88(n)
    62.28(a)
      175117  NM_064626.4  NP_497027.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRP2(YNR011C)4 RNA-dependent ATPase in the DEAH-box family, required more   --   14(646950-644320) 855745  NP_014408.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ESP31 ESP3 56.8(n)
    56.41(a)
      840143  NM_102984.4  NP_174527.2 
    rice
    (Oryza sativa)
    Liliopsida Os05g03898001 Os05g0389800 61.73(n)
    60.05(a)
      4338675  NM_001061972.1  NP_001055437.1 


    ENSEMBL Gene Tree for DHX16 (if available)
    TreeFam Gene Tree for DHX16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DHX16 gene
    DHX332  DHX352  DHX152  DQX12  DHX322  DHX82  
    10 SIMAP similar genes for DHX16 using alignment to 5 protein entries:     DHX16_HUMAN (see all proteins):
    DHX8    DHX15    DHX38    DHX35    DHX33    DKFZp762F2011
    DHX32    DHX40    DHX34    DQX1

    Find genes that share paralogs with DHX16           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DHX16 (see all 360)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1469615101,2
    --30621525(+) GCCTGA/GCTCTA 2 -- int10--------
    rs1916886491,2
    --30621631(+) CAGTGC/GCTCAC 2 -- int10--------
    rs1830404411,2
    --30621644(+) CTGTAA/GTCCCA 2 -- int10--------
    rs1863172791,2
    --30621664(+) GAGGCC/TGTGGC 2 -- int10--------
    rs1899046531,2
    --30621789(+) TACACC/TGGAGG 2 -- int10--------
    rs612300471,2
    C--30621835(+) GGTTG-/CA    
       TGAGC
    TGAGA
    2 -- int10--------
    rs1821749851,2
    --30621869(+) AGCCTG/TGGCTA 2 -- int10--------
    rs92810141,2
    C--30621892(+) CTCTCTC/-AAAAA 2 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs1405369321,2
    C--30621894(+) TCTCAA/CAAAAA 2 -- int10--------
    rs1417365571,2
    C--30622064(+) TTTGGG/TCTGGG 2 -- int10--------

    HapMap Linkage Disequilibrium report for DHX16 (30620896 - 30640830 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for DHX16:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670269CNV Deletion23128226
    esv2731791CNV Deletion23290073
    nsv884094CNV Loss21882294
    nsv830626CNV Loss17160897
    nsv823472CNV Gain20364138
    nsv884086CNV Gain21882294

    Human Gene Mutation Database (HGMD): DHX16
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DHX16
    DNA2.0 Custom Variant and Variant Library Synthesis for DHX16

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603405    OMIM disorders: --


    Find genes that share disorders with DHX16           About GenesLikeMe

    Genetic Association Database (GAD): DHX16
    Human Genome Epidemiology (HuGE) Navigator: DHX16 (3 documents)

    Export disorders for DHX16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DHX16 gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with DHX16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a human DEAH-box RNA helicase, a functional homolog of fission yeast Cdc28/Prp8. (PubMed id 9547260)1, 2, 3, 9 Imamura O.... Furuichi Y. (Nucleic Acids Res. 1998)
    2. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (DNA Res. 1998)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Dynamic protein-protein interaction wiring of the human spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (Mol. Cell 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8449 HGNC: 2739 AceView: DHX16 Ensembl:ENSG00000204560 euGenes: HUgn8449
    ECgene: DHX16 Kegg: 8449 H-InvDB: DHX16

    (According to HUGE)
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    HUGE: KIAA0577

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DHX16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DHX16 gene:
    Search GeneIP for patents involving DHX16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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