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Aliases for DHX16 Gene

Aliases for DHX16 Gene

  • DEAH-Box Helicase 16 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 16 2 3
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 16 2 3
  • ATP-Dependent RNA Helicase #3 3 4
  • DEAH-Box Protein 16 3 4
  • DDX16 3 4
  • DBP2 3 4
  • Putative Pre-MRNA-Splicing Factor ATP-Dependent RNA Helicase DHX16 3
  • DEAD/H Box 16 3
  • RNA Helicase 3
  • EC 4
  • KIAA0577 4
  • EC 3.6.1 61
  • PRO2014 3
  • PRPF2 3
  • PRP8 3
  • Prp2 3

External Ids for DHX16 Gene

Previous HGNC Symbols for DHX16 Gene

  • DDX16

Previous GeneCards Identifiers for DHX16 Gene

  • GC06M030391
  • GC06M030727
  • GC06M030728

Summaries for DHX16 Gene

Entrez Gene Summary for DHX16 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. This gene is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

GeneCards Summary for DHX16 Gene

DHX16 (DEAH-Box Helicase 16) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DHX8.

UniProtKB/Swiss-Prot for DHX16 Gene

  • Probable ATP-binding RNA helicase involved in pre-mRNA splicing.

Gene Wiki entry for DHX16 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX16 Gene

Genomics for DHX16 Gene

Regulatory Elements for DHX16 Gene

Enhancers for DHX16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G031567 2.1 FANTOM5 Ensembl ENCODE dbSUPER 62.9 -905.4 -905366 22.2 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YBX1 YY1 SLC30A9 ZNF143 DDX39B TNF LY6G5B LSM2 DHX16 ATF6B TCF19 PPP1R10 VARS CSNK2B
GH06G030746 2.1 FANTOM5 Ensembl ENCODE dbSUPER 48.5 -78.4 -78375 9.5 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF548 IER3 DHX16 LY6G5B GTF2H4 DDX39B PPP1R10 PAIP1P1 ABCF1 HLA-K VARS2
GH06G030715 1.5 ENCODE dbSUPER 55.7 -46.5 -46474 7.7 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 DHX16 DDX39B LY6G5B ABCF1 PAIP1P1 PPP1R10 TRIM26 HLA-K HLA-F-AS1 RPL3P2
GH06G030907 1.2 ENCODE 44.6 -235.4 -235405 2.2 CREB3L1 DMAP1 YBX1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 NFYC VARS2 GTF2H4 DHX16 HCG18 LY6G5B DDX39B LSM2 ABCF1 ETF1P1 PAIP1P1
GH06G031538 1.4 ENCODE dbSUPER 32.8 -868.1 -868086 4.9 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 MCM3 LSM2 DDX39B ATF6B LY6G5B PPP1R10 DHX16 RPL3P2 SKIV2L ATP6V1G2 MICB
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DHX16 on UCSC Golden Path with GeneCards custom track

Promoters for DHX16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000195423 353 1401 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207

Genomic Location for DHX16 Gene

30,653,119 bp from pter
30,673,053 bp from pter
19,935 bases
Minus strand

Genomic View for DHX16 Gene

Genes around DHX16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for DHX16 Gene

  • Protein details for DHX16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
    Protein Accession:
    Secondary Accessions:
    • O60322
    • Q5JP45
    • Q969X7
    • Q96QC1

    Protein attributes for DHX16 Gene

    1041 amino acids
    Molecular mass:
    119264 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA25503.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DHX16 Gene

Selected DME Specific Peptides for DHX16 Gene


Post-translational modifications for DHX16 Gene

  • Ubiquitination at isoforms=716
  • Modification sites at PhosphoSitePlus

Other Protein References for DHX16 Gene

Domains & Families for DHX16 Gene

Gene Families for DHX16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily.
  • Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily.
genes like me logo Genes that share domains with DHX16: view

Function for DHX16 Gene

Molecular function for DHX16 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Probable ATP-binding RNA helicase involved in pre-mRNA splicing.

Enzyme Numbers (IUBMB) for DHX16 Gene

Gene Ontology (GO) - Molecular Function for DHX16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA 22658674
GO:0003724 RNA helicase activity TAS 9547260
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
genes like me logo Genes that share ontologies with DHX16: view
genes like me logo Genes that share phenotypes with DHX16: view

Animal Model Products

CRISPR Products

miRNA for DHX16 Gene

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHX16 Gene

Localization for DHX16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX16 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHX16 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for DHX16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9547260
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DHX16: view

Pathways & Interactions for DHX16 Gene

genes like me logo Genes that share pathways with DHX16: view

Pathways by source for DHX16 Gene

1 KEGG pathway for DHX16 Gene

Gene Ontology (GO) - Biological Process for DHX16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing TAS 9547260
genes like me logo Genes that share ontologies with DHX16: view

No data available for SIGNOR curated interactions for DHX16 Gene

Drugs & Compounds for DHX16 Gene

(3) Drugs for DHX16 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for DHX16 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DHX16: view

Transcripts for DHX16 Gene

Unigene Clusters for DHX16 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX16 Gene

No ASD Table

Relevant External Links for DHX16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHX16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHX16 Gene

Protein differential expression in normal tissues from HIPED for DHX16 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.1), Cerebrospinal fluid (9.7), and Plasma (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DHX16 Gene

Protein tissue co-expression partners for DHX16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DHX16 Gene:


SOURCE GeneReport for Unigene cluster for DHX16 Gene:


Evidence on tissue expression from TISSUES for DHX16 Gene

  • Nervous system(4.7)
  • Liver(4.3)
  • Blood(2.3)
genes like me logo Genes that share expression patterns with DHX16: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHX16 Gene

Orthologs for DHX16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DHX16 34 35
  • 99.46 (n)
(Monodelphis domestica)
Mammalia DHX16 35
  • 95 (a)
(Bos Taurus)
Mammalia DHX16 34 35
  • 91.71 (n)
(Canis familiaris)
Mammalia DHX16 34 35
  • 91.67 (n)
(Mus musculus)
Mammalia Dhx16 34 16 35
  • 87.24 (n)
(Rattus norvegicus)
Mammalia Dhx16 34
  • 87.02 (n)
(Anolis carolinensis)
Reptilia DHX16 35
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.18519 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.3751 34
(Danio rerio)
Actinopterygii dhx16 34 35
  • 67.83 (n)
wufa91b12 34
fruit fly
(Drosophila melanogaster)
Insecta l(2)37Cb 34 35
  • 66.09 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009093 34
  • 63.02 (n)
(Caenorhabditis elegans)
Secernentea mog-4 34 35
  • 59.88 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP43 35
  • 44 (a)
PRP2 37
thale cress
(Arabidopsis thaliana)
eudicotyledons ESP3 34
  • 56.8 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9177 34
(Oryza sativa)
Liliopsida Os05g0389800 34
  • 61.73 (n)
(Triticum aestivum)
Liliopsida Ta.25604 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 60 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cdc28 34
  • 56.14 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08928 34
  • 54.67 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3838 34
Species where no ortholog for DHX16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DHX16 Gene

Gene Tree for DHX16 (if available)
Gene Tree for DHX16 (if available)

Paralogs for DHX16 Gene

Paralogs for DHX16 Gene

(10) SIMAP similar genes for DHX16 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DHX16: view

Variants for DHX16 Gene

Sequence variations from dbSNP and Humsavar for DHX16 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000218515 -- 30,673,554(+) CTCTA(A/C)TAAAA upstream-variant-2KB
rs1000255443 -- 30,655,501(+) GCATT(A/G)TCAGC nc-transcript-variant, reference, synonymous-codon
rs1000266637 -- 30,666,601(+) TCAGG(A/G)GTTAG intron-variant, upstream-variant-2KB
rs1000340780 -- 30,666,916(+) GATCA(A/T)GACCT intron-variant, upstream-variant-2KB
rs1000462425 -- 30,659,085(+) TTTCA(C/T)CACGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHX16 Gene

Variant ID Type Subtype PubMed ID
esv2670269 CNV deletion 23128226
esv2731791 CNV deletion 23290073
esv3411275 CNV duplication 20981092
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781
nsv823472 CNV gain 20364138
nsv830626 CNV loss 17160897

Variation tolerance for DHX16 Gene

Residual Variation Intolerance Score: 18.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.60; 65.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHX16 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX16 Gene

Disorders for DHX16 Gene

Relevant External Links for DHX16

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DHX16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX16 Gene

Publications for DHX16 Gene

  1. Cloning and characterization of a human DEAH-box RNA helicase, a functional homolog of fission yeast Cdc28/Prp8. (PMID: 9547260) Imamura O. … Furuichi Y. (Nucleic Acids Res. 1998) 2 3 4 22 64
  2. Contribution of DEAH-box protein DHX16 in human pre-mRNA splicing. (PMID: 20423332) Gencheva M. … Lin R.J. (Biochem. J. 2010) 2 3 64
  3. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu C.Y. … Christiani D.C. (Carcinogenesis 2010) 3 46 64
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 46 64
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64

Products for DHX16 Gene

Sources for DHX16 Gene