Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DHX16 Gene

protein-coding   GIFtS: 57
GCID: GC06M030620

DEAH (Asp-Glu-Ala-His) box polypeptide 16

(Previous name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 16 )
(Previous symbol: DDX16)
 Explore 6 diseases affiliated with
DHX16 via our new
 Human Malady Compendium 
Biological research products
for DHX16
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
DEAH (Asp-Glu-Ala-His) Box Polypeptide 161 2     PRP82 5
DBP21 2 3 5     PRO20142
DDX161 2 3 5     DEAD/H Box 162
PRPF21 2     Putative Pre-MRNA-Splicing Factor ATP-Dependent RNA Helicase DHX162
Prp21 2     RNA Helicase2
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 161 2     EC 3.6.4.133
ATP-Dependent RNA Helicase #32 3     KIAA05773
DEAH-Box Protein 162 3     EC 3.6.18

External Ids:    HGNC: 27391   Entrez Gene: 84492   Ensembl: ENSG000002045607   OMIM: 6034055   UniProtKB: O602313   

Export aliases for DHX16 gene to outside databases

Previous GC identifers: GC06M030391 GC06M030727 GC06M030728


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DHX16:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are
implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation
initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution
patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular
growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein
involved in cell cycle progression. This gene is mapped to the MHC region on chromosome 6p21.3, a region where many
malignant, genetic and autoimmune disease genes are linked. Two transcript variants encoding different isoforms have
been found for this gene. (provided by RefSeq, Aug 2009)

UniProtKB/Swiss-Prot: DHX16_HUMAN, O60231
Function: Probable ATP-binding RNA helicase involved in pre-mRNA splicing

Gene Wiki entry for DHX16


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167246.1  NT_167247.1  
NT_167248.1  NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DHX16 gene promoter:
         TBP   AML1a   NF-kappaB   E47   Max   NF-kappaB2   ARP-1   Hand1   NF-kappaB1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DHX16 promoter sequence
   Search SABiosciences Chromatin IP Primers for DHX16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHX16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

DHX16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHX16 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M030620:  view genomic region     (about GC identifiers)

Start:
30,620,896 bp from pter      End:
30,640,830 bp from pter
Size:
19,935 bases      Orientation:
minus strand

6/7 alternative locations (see all 7):
Chr6-,ALT_REF_LOCI_5 30,614,177-30,634,138      Chr6-,ALT_REF_LOCI_3 30,611,130-30,642,133      Chr6-,ALT_REF_LOCI_6 30,610,400-30,665,946     
Chr6-,ALT_REF_LOCI_4 30,588,622-30,608,585      Chr6-,ALT_REF_LOCI_2 30,610,735-30,669,887      Chr6-,ALT_REF_LOCI_1 30,635,497-30,657,378     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DHX16_HUMAN, O60231 (See protein sequence)
Recommended Name: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16  
Size: 1041 amino acids; 119264 Da
Subcellular location: Nucleus
Sequence caution: Sequence=BAA25503.2; Type=Erroneous initiation;
Secondary accessions: O60322 Q5JP45 Q969X7 Q96QC1

Explore the universe of human proteins at neXtProt for DHX16: NX_O60231

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60231

  • 4/16 DME Specific Peptides for DHX16 (O60231) (see all 16)
     TNIAETS  VGYSIRF  FLTGQEE  TVPEIQR 

    DHX16 Protein expression data from MOPED and PaxDb:    About this image 
    DHX16 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001157711.1  NP_003578.2  

    ENSEMBL proteins: 
     ENSP00000365625   ENSP00000365620   ENSP00000399101  

    Human Recombinant Protein Products for DHX16: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: DHX16
    OriGene Protein Over-expression Lysate: DHX16
    OriGene Custom Protein Services for DHX16 
    GenScript Custom Purified and Recombinant Proteins Services for DHX16
    Novus Biologicals DHX16 Protein
    Novus Biologicals DHX16 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DHX16

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    DHX16 for ontologies           About GeneDecksing



    DHX16 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DHX16 
    GenScript Custom Superior Antibodies Services for DHX16
    Novus Biologicals DHX16 Antibodies
    Abcam antibodies for DHX16 
    Uscn Antibodies for DHX16
    Search ThermoFisher Antibodies for DHX16

    Assay Products for DHX16: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DHX16
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for DHX16


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    DHX16 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR007502 Helicase-assoc_dom
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR011709 DUF1605
     IPR002464 DNA/RNA_helicase_DEAH_CS
     IPR014001 Helicase_ATP-bd

    Graphical View of Domain Structure for InterPro Entry O60231

    ProtoNet protein and cluster: O60231

    2 Blocks protein families:
    IPB002464 ATP-dependent helicase
    IPB007502 Helicase-associated region


    UniProtKB/Swiss-Prot: DHX16_HUMAN, O60231
    Similarity: Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DHX16_HUMAN, O60231
    Function: Probable ATP-binding RNA helicase involved in pre-mRNA splicing
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0003724RNA helicase activity TAS9547260
    GO:0005524ATP binding IEA--
    GO:0008026ATP-dependent helicase activity IEA--
         
    DHX16 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DHX16 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 2): DHX16
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DHX16
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate DHX16:
    hsa-miR-188-3p hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidDHX16 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DHX16 (see all 7)
    OriGene shRNA RFP: DHX16
    OriGene siRNA: DHX16
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DHX16
    Sirion Biotech Custom design and validation of potent shRNA sequences against DHX16 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DHX16
    Sirion Biotech Customized adenovirus for overexpression of DHX16 
    Sirion Biotech Customized adenovirus for potent knockdown of DHX16

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DHX16 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DHX16 (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): DHX16 (NM_001164239)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHX16
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX16 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DHX16
    Search LifeMap BioReagents cell lines for DHX16
    Sirion Biotech Customized stable knockdown cell line services for DHX16 
    Sirion Biotech Customized inducible knockdown cell line services for DHX16
    Sirion Biotech Customized stable overexpressing cell line services for DHX16
    Sirion Biotech Customized inducible overexpressing cell line services for DHX16

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX16


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA Splicing - Major Pathway
    mRNA processing0.48
    Spliceosome0.31

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for DHX16 
        mRNA processing


    1         Kegg Pathway  (Kegg details for DHX16):
        Spliceosome


    DHX16 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DHX16

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/23 Interacting proteins for DHX16 (O602312, 3 ENSP000003656254) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COILP384322, 3, ENSP000002403164MINT-2865160 I2D: score=3 STRING: ENSP00000240316
    DHX38Q926202, 3MINT-8331635 MINT-8337640 I2D: score=1 
    MEGF10Q96KG73, ENSP000002744734I2D: score=2 STRING: ENSP00000274473
    GPKOWQ929172MINT-8337662 MINT-8331646
    SF3B2Q134352MINT-8332361 MINT-8333614
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--

    DHX16 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DHX16

    1 HMDB Compound for DHX16    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Search CenterWatch for drugs/clinical trials and news about DHX16 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DHX16 gene (2 alternative transcripts): 
    NM_001164239.1  NM_003587.4  

    Unigene Cluster for DHX16:

    DEAH (Asp-Glu-Ala-His) box polypeptide 16
    Hs.485060  [show with all ESTs]
    Unigene Representative Sequence: NM_003587
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376442(uc011dmo.2 uc003nqz.3) ENST00000376437(uc003nqy.3)
    ENST00000480966 ENST00000415603

    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 2): DHX16
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DHX16
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate DHX16:
    hsa-miR-188-3p hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidDHX16 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DHX16 (see all 7)
    OriGene shRNA RFP: DHX16
    OriGene siRNA: DHX16
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DHX16
    Sirion Biotech Custom design and validation of potent shRNA sequences against DHX16 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DHX16 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DHX16 (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): DHX16 (NM_001164239)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHX16
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX16 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DHX16
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DHX16
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DHX16
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHX16

    Additional cDNA sequence: 

    AB001601.1 AF119860.1 AK302721.1 AK312264.1 BC002789.2 BC008825.2 BC009392.2 

    15 DOTS entries:

    DT.97860002  DT.100787658  DT.91998700  DT.121360219  DT.40130931  DT.100030798  DT.100786921  DT.97860004 
    DT.100786930  DT.97860003  DT.91901099  DT.121360333  DT.100650943  DT.100733165  DT.95226768 

    19 AceView cDNA sequences:

    BC008825 BC002789 BC009392 AF119860 CR591941 NM_003587 BG315341 BQ311555 
    AB001601 AA492431 BE839261 BQ333691 AW610220 BQ292037 BE708164 AB011149 
    BF375726 BQ311619 BQ315816 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DHX16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTAAGAAAAT
    DHX16 Expression
    About this image
    See DHX16 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DHX16

    SOURCE GeneReport for Unigene cluster: Hs.485060
        SABiosciences Custom PCR Arrays for DHX16

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DHX16
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DHX16
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DHX16
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHX16
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for DHX16 gene from 9/35 species (see all 35)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia DHX166
    --
    88(a)
    1 ↔ 1
    2(192116099-192134049)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.37512 Xenopus laevis transcribed sequence with moderate similarity more 74.36(n)    BJ072880.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa91b122 wufa91b12 76.27(n)   336645  BC045393.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(2)37Cb1 lethal (2) 37Cb 65.68(n)
    66.89(a)
      35192  NM_136102.3  NP_609946.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mog-41 Protein MOG-4 57.45(n)
    57.72(a)
      175117  NM_064626.3  NP_497027.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRP2(YNR011C)4
    PRP21
    RNA-dependent ATPase in the DEAH-box family, required more4
    Prp2p1
    50.61(n)1
    50.07(a)1
      14(646950-644320)4
    8557451, 4  NP_014408.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ESP31 pre-mRNA-splicing factor ATP-dependent RNA helicase more 56.62(n)
    56.43(a)
      840143  NM_102984.4  NP_174527.2 
    rice
    (Oryza sativa)
    Liliopsida Os05g03898001 hypothetical protein 58.44(n)
    54.45(a)
      4338675  NM_001061972.1  NP_001055437.1 
    E. coli
    (Escherichia coli)
    Gamma proteobacteria hrpB6
    hrpA6
    predicted ATP-dependent helicase
    21(a)
    17(a)
    possible ortholog
    possible ortholog
    Chromosome(162105-164534)
    Chromosome(1481085-1484987)


    ENSEMBL Gene Tree for DHX16 (if available)
    TreeFam Gene Tree for DHX16 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DHX16 gene
    DHX402  YTHDC22  DHX572  DHX352  DHX92  DHX292  DHX362  DHX302  
    TDRD92  DHX332  DHX382  DHX82  
    11 SIMAP similar genes for DHX16 using alignment to 9 protein entries:     DHX16_HUMAN (see all proteins):
    DHX8    DHX38    DHX15    DHX35    DHX33    DKFZp762F2011
    DHX40    DHX32    DHX34    DQX1    DHX30

    DHX16 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/387 NCBI SNPs in DHX16 are shown (see all 387    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs11279561,2
    C--30620495(+) ATAAAG/TTGAGT 5 -- spd1 ds50011Minor allele frequency- T:0.00NA 2
    rs412730011,2
    F--30620528(+) AAAGGG/ATAGAA 5 -- int1 ds50012Minor allele frequency- A:0.04WA EA 238
    rs1426827471,2
    --30620834(+) AGCTGC/TTGTGT 5 -- ds5001 ut310--------
    rs11279551,2
    C--30620976(+) GTATAA/GAAGGA 5 -- ut31 trp30--------
    rs1419237331,2
    C--30621054(+) TTTTTT/GGGGCA 7 /K /Q int1 mis11Minor allele frequency- G:0.00NA 4542
    rs1893933591,2
    --30621170(+) TCAATA/GGAGTT 5 -- int10--------
    rs1430238551,2
    --30621199(+) ATCTT-/TTGTTGTT 5 -- int10--------
    rs1816811831,2
    --30621278(+) ATCATA/GGCTCA 5 -- int10--------
    rs1868543101,2
    --30621325(+) GACTAC/GAGGCA 5 -- int10--------
    rs1403295471,2
    C--30621393(+) CTGAT-/CTTGGCCTCCCAA
    AGTGCTAGGATCCTGC
    CTTGG
    5 -- int10--------

    HapMap Linkage Disequilibrium report for DHX16 (30620896 - 30640830 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DHX16: --
    Human Gene Mutation Database (HGMD): DHX16

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DHX16
    DNA2.0 Custom Variant and Variant Library Synthesis for DHX16

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DHX16 for disorders           About GeneDecksing

    OMIM gene information: 603405    OMIM disorders: --

    6 diseases for DHX16:    About MalaCards
    systemic lupus erythematosus    lupus erythematosus    ataxia    esophagitis
    adenocarcinoma    malaria

    Human Genome Epidemiology (HuGE) Navigator: DHX16 (3 documents)

    Export disorders for DHX16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DHX16 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with DHX16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a human DEAH-box RNA helicase, a functional homolog of fission yeast Cdc28/Prp8. (PubMed id 9547260)1, 2, 3, 9 Imamura O.... Furuichi Y. (1998)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (1998)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    8. A catalogue of putative HIV-1 protease host cell subst rates. (PubMed id 22944692)1 Impens F....Gevaert K. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8449 HGNC: 2739 AceView: DHX16 Ensembl:ENSG00000204560 euGenes: HUgn8449
    ECgene: DHX16 Kegg: 8449 H-InvDB: DHX16

    (According to HUGE)
    About This Section
    HUGE: KIAA0577

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DHX16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DHX16 gene:
    Search GeneIP for patents involving DHX16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for DHX16  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DHX16   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DHX16  
     OriGene Protein Over-expression Lysate for DHX16   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for DHX16   OriGene 3'-UTR Clone for DHX16  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DHX16   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DHX16  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for DHX16   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DHX16   OriGene Custom Protein Services for DHX16  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DHX16
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DHX16
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHX16
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DHX16
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHX16
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DHX16
     GenScript Custom Purified and Recombinant Proteins Services for DHX16 GenScript cDNA clones with any tag delivered in your preferred vector for DHX16
     GenScript Custom Assay Services for DHX16 GenScript Custom Superior Antibodies Services for DHX16
     GenScript Custom overexpressing Cell Line Services for DHX16 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in DHX16 promoter
     Search Chromatin IP Primers for DHX16
     RT2 qPCR Primer Assay in human, mouse, rat DHX16
     Search GNC Networks for DHX16
     SABiosciences Custom PCR Arrays for DHX16
     Search Tocris compounds for DHX16
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     DHX16 antibodies
     DHX16 proteins
     DHX16 lysates
     Antibodies for DHX16
     See all of Abcam's Antibodies, Kits and Proteins for DHX16
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     DHX16 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for DHX16
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX16
     SwitchGear 3'UTR luciferase reporter plasmids for DHX16
     SwitchGear Promoter luciferase reporter plasmids for DHX16
     Search ThermoFisher Antibodies for DHX16
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX16
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DHX16
    Sirion Biotech Customized:
     stable knockdown cell line services for DHX16
     inducible knockdown cell line services for DHX16
     design and validation of potent shRNA sequences against DHX16
     adenovirus for potent knockdown of DHX16
     adenovirus for overexpression of DHX16
     stable overexpressing cell line services for DHX16
     inducible overexpressing cell line services for DHX16
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DHX16 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4