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Aliases for DHX16 Gene

Aliases for DHX16 Gene

  • DEAH-Box Helicase 16 2 3
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 16 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 16 2 3
  • ATP-Dependent RNA Helicase #3 3 4
  • DEAH-Box Protein 16 3 4
  • DDX16 3 4
  • DBP2 3 4
  • DEAD/H Box 16 3
  • RNA Helicase 3
  • EC 4
  • KIAA0577 4
  • EC 3.6.1 63
  • PRO2014 3
  • PRPF2 3
  • PRP8 3
  • Prp2 3

External Ids for DHX16 Gene

Previous HGNC Symbols for DHX16 Gene

  • DDX16

Previous GeneCards Identifiers for DHX16 Gene

  • GC06M030391
  • GC06M030727
  • GC06M030728

Summaries for DHX16 Gene

Entrez Gene Summary for DHX16 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. This gene is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

GeneCards Summary for DHX16 Gene

DHX16 (DEAH-Box Helicase 16) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DHX35.

UniProtKB/Swiss-Prot for DHX16 Gene

  • Probable ATP-binding RNA helicase involved in pre-mRNA splicing.

Gene Wiki entry for DHX16 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX16 Gene

Genomics for DHX16 Gene

Regulatory Elements for DHX16 Gene

Enhancers for DHX16 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DHX16 on UCSC Golden Path with GeneCards custom track

Promoters for DHX16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DHX16 on UCSC Golden Path with GeneCards custom track

Genomic Location for DHX16 Gene

30,653,119 bp from pter
30,673,053 bp from pter
19,935 bases
Minus strand

Genomic View for DHX16 Gene

Genes around DHX16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for DHX16 Gene

  • Protein details for DHX16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
    Protein Accession:
    Secondary Accessions:
    • O60322
    • Q5JP45
    • Q969X7
    • Q96QC1

    Protein attributes for DHX16 Gene

    1041 amino acids
    Molecular mass:
    119264 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA25503.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DHX16 Gene

Proteomics data for DHX16 Gene at MOPED

Post-translational modifications for DHX16 Gene

  • Ubiquitination at Lys 716
  • Modification sites at PhosphoSitePlus

Other Protein References for DHX16 Gene

Domains & Families for DHX16 Gene

Gene Families for DHX16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily.
genes like me logo Genes that share domains with DHX16: view

Function for DHX16 Gene

Molecular function for DHX16 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Probable ATP-binding RNA helicase involved in pre-mRNA splicing.

Enzyme Numbers (IUBMB) for DHX16 Gene

Gene Ontology (GO) - Molecular Function for DHX16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22365833
GO:0005524 ATP binding IEA --
GO:0008026 ATP-dependent helicase activity IEA --
genes like me logo Genes that share ontologies with DHX16: view
genes like me logo Genes that share phenotypes with DHX16: view

Animal Model Products

miRNA for DHX16 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHX16 Gene

Localization for DHX16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX16 Gene

Subcellular locations from

Jensen Localization Image for DHX16 Gene COMPARTMENTS Subcellular localization image for DHX16 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for DHX16 Gene

Pathways & Interactions for DHX16 Gene

genes like me logo Genes that share pathways with DHX16: view

Pathways by source for DHX16 Gene

1 KEGG pathway for DHX16 Gene

Gene Ontology (GO) - Biological Process for DHX16 Gene


No data available for SIGNOR curated interactions for DHX16 Gene

Drugs & Compounds for DHX16 Gene

(1) Drugs for DHX16 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DHX16 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with DHX16: view

Transcripts for DHX16 Gene

Unigene Clusters for DHX16 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 16:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX16 Gene

No ASD Table

Relevant External Links for DHX16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHX16 Gene

mRNA expression in normal human tissues for DHX16 Gene

Protein differential expression in normal tissues from HIPED for DHX16 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.1), Cerebrospinal fluid (9.7), and Plasma (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHX16 Gene

SOURCE GeneReport for Unigene cluster for DHX16 Gene Hs.485060

genes like me logo Genes that share expression patterns with DHX16: view

Protein tissue co-expression partners for DHX16 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DHX16 Gene

Orthologs for DHX16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DHX16 35
  • 91.71 (n)
  • 97.89 (a)
DHX16 36
  • 98 (a)
(Canis familiaris)
Mammalia DHX16 35
  • 91.67 (n)
  • 97.31 (a)
DHX16 36
  • 97 (a)
(Mus musculus)
Mammalia Dhx16 35
  • 87.24 (n)
  • 94.9 (a)
Dhx16 16
Dhx16 36
  • 96 (a)
(Pan troglodytes)
Mammalia DHX16 35
  • 99.46 (n)
  • 99.42 (a)
DHX16 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Dhx16 35
  • 87.02 (n)
  • 95 (a)
(Monodelphis domestica)
Mammalia DHX16 36
  • 95 (a)
(Anolis carolinensis)
Reptilia DHX16 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.18519 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3751 35
(Danio rerio)
Actinopterygii dhx16 35
  • 67.83 (n)
  • 73.24 (a)
wufa91b12 35
dhx16 36
  • 73 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009093 35
  • 63.02 (n)
  • 66.25 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(2)37Cb 35
  • 66.09 (n)
  • 67.24 (a)
l(2)37Cb 36
  • 65 (a)
(Caenorhabditis elegans)
Secernentea mog-4 35
  • 59.88 (n)
  • 62.28 (a)
mog-4 36
  • 57 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP43 36
  • 44 (a)
PRP2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ESP3 35
  • 56.8 (n)
  • 56.41 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9177 35
(Oryza sativa)
Liliopsida Os05g0389800 35
  • 61.73 (n)
  • 60.05 (a)
(Triticum aestivum)
Liliopsida Ta.25604 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3838 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08928 35
  • 54.67 (n)
  • 52.34 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cdc28 35
  • 56.14 (n)
  • 56.42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
Species with no ortholog for DHX16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DHX16 Gene

Gene Tree for DHX16 (if available)
Gene Tree for DHX16 (if available)

Paralogs for DHX16 Gene

Paralogs for DHX16 Gene

(10) SIMAP similar genes for DHX16 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DHX16: view

Variants for DHX16 Gene

Sequence variations from dbSNP and Humsavar for DHX16 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs17189239 - 30,665,142(+) ATACT(C/T)GGGCT reference, missense
rs17189232 - 30,662,667(+) CCGGA(A/G)AAGCA upstream-variant-2KB, reference, missense
rs9262138 - 30,660,090(+) GGGCG(C/T)CATCA reference, missense
rs1076828 -- 30,660,475(-) CTTGT(C/T)TCCTA intron-variant
rs1076829 -- 30,659,439(+) AAGCA(C/T)AGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHX16 Gene

Variant ID Type Subtype PubMed ID
esv2731791 CNV Deletion 23290073
nsv884086 CNV Gain 21882294
esv2670269 CNV Deletion 23128226
nsv830626 CNV Loss 17160897
nsv884094 CNV Loss 21882294
nsv823472 CNV Gain 20364138

Variation tolerance for DHX16 Gene

Residual Variation Intolerance Score: 18.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.60; 65.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHX16 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX16 Gene

Disorders for DHX16 Gene

Relevant External Links for DHX16

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DHX16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX16 Gene

Publications for DHX16 Gene

  1. Cloning and characterization of a human DEAH-box RNA helicase, a functional homolog of fission yeast Cdc28/Prp8. (PMID: 9547260) Imamura O. … Furuichi Y. (Nucleic Acids Res. 1998) 2 3 4 23 67
  2. Contribution of DEAH-box protein DHX16 in human pre-mRNA splicing. (PMID: 20423332) Gencheva M. … Lin R.J. (Biochem. J. 2010) 2 3
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  4. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for DHX16 Gene

Sources for DHX16 Gene