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Aliases for DHX16 Gene

Aliases for DHX16 Gene

  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 16 2 3
  • DDX16 3 4 6
  • DBP2 3 4 6
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 16 2 3
  • ATP-Dependent RNA Helicase #3 3 4
  • DEAH-Box Protein 16 3 4
  • PRP8 3 6
  • Putative Pre-MRNA-Splicing Factor ATP-Dependent RNA Helicase DHX16 3
  • DEAD/H Box 16 3
  • RNA Helicase 3
  • EC 3.6.4.13 4
  • KIAA0577 4
  • EC 3.6.1 64
  • PRO2014 3
  • PRPF2 3
  • Prp2 3

External Ids for DHX16 Gene

Previous Symbols for DHX16 Gene

  • DDX16

Summaries for DHX16 Gene

Entrez Gene Summary for DHX16 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. This gene is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

GeneCards Summary for DHX16 Gene

DHX16 (DEAH (Asp-Glu-Ala-His) Box Polypeptide 16) is a Protein Coding gene. Among its related pathways are Spliceosome and mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and RNA helicase activity. An important paralog of this gene is DHX35.

UniProtKB/Swiss-Prot for DHX16 Gene

  • Probable ATP-binding RNA helicase involved in pre-mRNA splicing

Gene Wiki entry for DHX16 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX16 Gene

Genomics for DHX16 Gene

Genomic Location for DHX16 Gene

Start:
30,653,119 bp from pter
End:
30,673,053 bp from pter
Size:
19,935 bases
Orientation:
Minus strand

Genomic View for DHX16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHX16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for DHX16 Gene

Proteins for DHX16 Gene

  • Protein details for DHX16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60231-DHX16_HUMAN
    Recommended name:
    Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
    Protein Accession:
    O60231
    Secondary Accessions:
    • O60322
    • Q5JP45
    • Q969X7
    • Q96QC1

    Protein attributes for DHX16 Gene

    Size:
    1041 amino acids
    Molecular mass:
    119264 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA25503.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DHX16 Gene

Proteomics data for DHX16 Gene at MOPED

Post-translational modifications for DHX16 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys716

Other Protein References for DHX16 Gene

Domains for DHX16 Gene

Gene Families for DHX16 Gene

HGNC:
  • DHX :DEAH-boxes

UniProtKB/Swiss-Prot:

DHX16_HUMAN
Domain:
  • Contains 1 helicase ATP-binding domain.:
    • O60231
  • Contains 1 helicase C-terminal domain.:
    • O60231
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily.:
    • O60231
genes like me logo Genes that share domains with DHX16: view

Function for DHX16 Gene

Molecular function for DHX16 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: Probable ATP-binding RNA helicase involved in pre-mRNA splicing

Enzyme Numbers (IUBMB) for DHX16 Gene

Gene Ontology (GO) - Molecular Function for DHX16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003724 RNA helicase activity TAS 9547260
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity --
GO:0005515 protein binding IPI 22365833
genes like me logo Genes that share ontologies with DHX16: view

miRNA for DHX16 Gene

miRTarBase miRNAs that target DHX16

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DHX16 Gene

Localization for DHX16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX16 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHX16 Gene COMPARTMENTS Subcellular localization image for DHX16 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for DHX16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9547260
GO:0005654 nucleoplasm IDA --
GO:0005681 spliceosomal complex IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DHX16: view

Pathways for DHX16 Gene

SuperPathways for DHX16 Gene

Superpath Contained pathways
1 Spliceosome
2 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with DHX16: view

Pathways by source for DHX16 Gene

1 BioSystems pathway for DHX16 Gene
1 KEGG pathway for DHX16 Gene

Gene Ontology (GO) - Biological Process for DHX16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IBA --
GO:0006200 obsolete ATP catabolic process --
GO:0006397 mRNA processing --
GO:0008380 RNA splicing TAS 9547260
genes like me logo Genes that share ontologies with DHX16: view

Compounds for DHX16 Gene

(1) HMDB Compounds for DHX16 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
genes like me logo Genes that share compounds with DHX16: view

Transcripts for DHX16 Gene

Unigene Clusters for DHX16 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHX16 Gene

No ASD Table

Relevant External Links for DHX16 Gene

GeneLoc Exon Structure for
DHX16
ECgene alternative splicing isoforms for
DHX16

Expression for DHX16 Gene

mRNA expression in normal human tissues for DHX16 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHX16 Gene

SOURCE GeneReport for Unigene cluster for DHX16 Gene Hs.485060

genes like me logo Genes that share expressions with DHX16: view

Orthologs for DHX16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHX16 36
  • 99.46 (n)
  • 99.42 (a)
DHX16 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DHX16 36
  • 91.71 (n)
  • 97.89 (a)
DHX16 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DHX16 36
  • 91.67 (n)
  • 97.31 (a)
DHX16 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dhx16 36
  • 87.24 (n)
  • 94.9 (a)
Dhx16 16
Dhx16 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DHX16 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dhx16 36
  • 87.02 (n)
  • 95 (a)
lizard
(Anolis carolinensis)
Reptilia DHX16 37
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3751 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.18519 36
zebrafish
(Danio rerio)
Actinopterygii dhx16 36
  • 67.83 (n)
  • 73.24 (a)
dhx16 37
  • 73 (a)
OneToOne
wufa91b12 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009093 36
  • 63.02 (n)
  • 66.25 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(2)37Cb 36
  • 66.09 (n)
  • 67.24 (a)
l(2)37Cb 37
  • 65 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mog-4 36
  • 59.88 (n)
  • 62.28 (a)
mog-4 37
  • 57 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP2 39
PRP43 37
  • 44 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9177 36
thale cress
(Arabidopsis thaliana)
eudicotyledons ESP3 36
  • 56.8 (n)
  • 56.41 (a)
rice
(Oryza sativa)
Liliopsida Os05g0389800 36
  • 61.73 (n)
  • 60.05 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.25604 36
bread mold
(Neurospora crassa)
Ascomycetes NCU08928 36
  • 54.67 (n)
  • 52.34 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cdc28 36
  • 56.14 (n)
  • 56.42 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3838 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 60 (a)
OneToOne
Species with no ortholog for DHX16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DHX16 Gene

ENSEMBL:
Gene Tree for DHX16 (if available)
TreeFam:
Gene Tree for DHX16 (if available)

Paralogs for DHX16 Gene

Paralogs for DHX16 Gene

Selected SIMAP similar genes for DHX16 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DHX16: view

Variants for DHX16 Gene

Sequence variations from dbSNP and Humsavar for DHX16 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1076828 -- 30,660,475(-) CTTGT(C/T)TCCTA intron-variant
rs1076829 -- 30,659,439(+) AAGCA(C/T)AGGGG intron-variant
rs1109146 -- 30,661,871(-) CAAAA(A/G)ATCTC intron-variant
rs1124795 -- 30,656,378(-) GGGGG(A/G)CAGCA intron-variant
rs1127932 -- 30,656,447(+) CAAAG(C/T)CAGCA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for DHX16 Gene

Variant ID Type Subtype PubMed ID
esv2731791 CNV Deletion 23290073
nsv884086 CNV Gain 21882294
esv2670269 CNV Deletion 23128226
nsv830626 CNV Loss 17160897
nsv884094 CNV Loss 21882294
nsv823472 CNV Gain 20364138

Relevant External Links for DHX16 Gene

HapMap Linkage Disequilibrium report
DHX16
Human Gene Mutation Database (HGMD)
DHX16

Disorders for DHX16 Gene

Relevant External Links for DHX16

Genetic Association Database (GAD)
DHX16
Human Genome Epidemiology (HuGE) Navigator
DHX16
genes like me logo Genes that share disorders with DHX16: view

No data available for UniProtKB/Swiss-Prot for DHX16 Gene

Publications for DHX16 Gene

  1. Cloning and characterization of a human DEAH-box RNA helicase, a functional homolog of fission yeast Cdc28/Prp8. (PMID: 9547260) Imamura O. … Furuichi Y. (Nucleic Acids Res. 1998) 2 3 4 23
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 49
  4. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for DHX16 Gene

Sources for DHX16 Gene

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