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Aliases for DHX15 Gene

Aliases for DHX15 Gene

  • DEAH-Box Helicase 15 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 15 2 3
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 15 2 3
  • DEAH (Asp-Glu-Ala-His) Box Helicase 15 2 3
  • ATP-Dependent RNA Helicase #46 3 4
  • DEAH Box Protein 15 3 4
  • DDX15 3 4
  • DBP1 3 4
  • Putative Pre-MRNA-Splicing Factor ATP-Dependent RNA Helicase DHX15 3
  • Pre-MRNA-Splicing Factor ATP-Dependent RNA Helicase DHX15 3
  • RNA Helicase 2 3
  • DEAD/H Box-15 3
  • EC 3.6.4.13 4
  • EC 3.6.1 61
  • PrPp43p 3
  • PRPF43 3
  • PRP43 3
  • HRH2 3

External Ids for DHX15 Gene

Previous HGNC Symbols for DHX15 Gene

  • DDX15

Previous GeneCards Identifiers for DHX15 Gene

  • GC04M024217
  • GC04M024279
  • GC04M024205
  • GC04M024138
  • GC04M024529
  • GC04M023871

Summaries for DHX15 Gene

Entrez Gene Summary for DHX15 Gene

  • The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing. [provided by RefSeq, Jul 2008]

GeneCards Summary for DHX15 Gene

DHX15 (DEAH-Box Helicase 15) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DHX35.

UniProtKB/Swiss-Prot for DHX15 Gene

  • Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns.

Gene Wiki entry for DHX15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX15 Gene

Genomics for DHX15 Gene

Regulatory Elements for DHX15 Gene

Enhancers for DHX15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F024469 1.6 FANTOM5 Ensembl ENCODE 37.5 +112.9 112907 4.2 ATF1 SIN3A FEZF1 GLI4 ZNF2 ZNF48 ZNF121 ZNF766 GLIS2 FOS DHX15 ANAPC4 PI4K2B SEPSECS LOC107986266 PPARGC1A GC04P024448
GH04F025309 1.2 Ensembl ENCODE 22.6 -726.1 -726086 1.7 HDGF ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ANAPC4 DHX15 SOD3 ZCCHC4 GC04P025283
GH04F025158 0.5 ENCODE 22 -576.0 -575957 3.8 HDGF MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ANAPC4 DHX15 PI4K2B SEPSECS PIR60918
GH04F024687 0.2 ENCODE 19.6 -102.7 -102747 0.6 CTCF PKNOX1 TRIM22 ZNF384 REST RAD21 GATA3 GATA2 SMC3 GATA1 DHX15 MIR573 SOD3 LOC107986266 PIR57270
GH04F024642 1.2 Ensembl ENCODE 17.8 -58.9 -58852 1.9 FEZF1 ZBTB40 TEAD3 ZNF335 ZNF316 FOS NFE2 MAFK TEAD1 BHLHE40 DHX15 LOC107986266 GC04M024658
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DHX15 on UCSC Golden Path with GeneCards custom track

Promoters for DHX15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001430166 703 3001 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for DHX15 Gene

Chromosome:
4
Start:
24,517,441 bp from pter
End:
24,584,603 bp from pter
Size:
67,163 bases
Orientation:
Minus strand

Genomic View for DHX15 Gene

Genes around DHX15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX15 Gene

Proteins for DHX15 Gene

  • Protein details for DHX15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43143-DHX15_HUMAN
    Recommended name:
    Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
    Protein Accession:
    O43143
    Secondary Accessions:
    • Q9NQT7

    Protein attributes for DHX15 Gene

    Size:
    795 amino acids
    Molecular mass:
    90933 Da
    Quaternary structure:
    • Interacts with SSB/La (PubMed:12458796). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome (PubMed:15146077). Identified in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors; the association may be transient. Interacts with TFIP11; indicative for a recruitment to the IL complex (PubMed:19103666). Interacts with GPATCH2 (PubMed:19432882).

neXtProt entry for DHX15 Gene

Post-translational modifications for DHX15 Gene

  • Ubiquitination at Lys 143, Lys 230, Lys 234, Lys 463, Lys 491, and Lys 790
  • Modification sites at PhosphoSitePlus

Other Protein References for DHX15 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for DHX15 Gene

Gene Families for DHX15 Gene

Suggested Antigen Peptide Sequences for DHX15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43143

UniProtKB/Swiss-Prot:

DHX15_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.
genes like me logo Genes that share domains with DHX15: view

Function for DHX15 Gene

Molecular function for DHX15 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns.

Enzyme Numbers (IUBMB) for DHX15 Gene

Gene Ontology (GO) - Molecular Function for DHX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003724 RNA helicase activity TAS 7935475
GO:0003725 double-stranded RNA binding IDA 21266579
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
genes like me logo Genes that share ontologies with DHX15: view
genes like me logo Genes that share phenotypes with DHX15: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHX15 Gene

Localization for DHX15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX15 Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHX15 Gene COMPARTMENTS Subcellular localization image for DHX15 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for DHX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA --
GO:0005689 U12-type spliceosomal complex IDA 15146077
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IBA --
GO:0071008 colocalizes_with U2-type post-mRNA release spliceosomal complex IDA 19103666
genes like me logo Genes that share ontologies with DHX15: view

Pathways & Interactions for DHX15 Gene

genes like me logo Genes that share pathways with DHX15: view

Pathways by source for DHX15 Gene

1 KEGG pathway for DHX15 Gene

Gene Ontology (GO) - Biological Process for DHX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IBA --
GO:0006397 mRNA processing IEA,TAS 7935475
GO:0008380 RNA splicing IEA,IC 15146077
GO:0009636 response to toxic substance IEA --
GO:0043279 response to alkaloid IEA --
genes like me logo Genes that share ontologies with DHX15: view

No data available for SIGNOR curated interactions for DHX15 Gene

Drugs & Compounds for DHX15 Gene

(3) Drugs for DHX15 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for DHX15 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DHX15: view

Transcripts for DHX15 Gene

Unigene Clusters for DHX15 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 15:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX15 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c ^
SP1: -
SP2: - -
SP3:
SP4: -
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12:
SP13: - - -
SP14: -
SP15:
SP16:

ExUns: 16a · 16b · 16c ^ 17a · 17b · 17c ^ 18a · 18b · 18c · 18d
SP1:
SP2: - -
SP3:
SP4: -
SP5: - -
SP6: - -
SP7:
SP8:
SP9: - -
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15: - - -
SP16:

Relevant External Links for DHX15 Gene

GeneLoc Exon Structure for
DHX15
ECgene alternative splicing isoforms for
DHX15

Expression for DHX15 Gene

mRNA expression in normal human tissues for DHX15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DHX15 Gene

This gene is overexpressed in Lymph node (9.2) and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DHX15 Gene



Protein tissue co-expression partners for DHX15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DHX15 Gene:

DHX15

SOURCE GeneReport for Unigene cluster for DHX15 Gene:

Hs.696074

mRNA Expression by UniProt/SwissProt for DHX15 Gene:

O43143-DHX15_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with DHX15: view

Primer Products

No data available for mRNA differential expression in normal tissues for DHX15 Gene

Orthologs for DHX15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX15 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia DHX15 35
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DHX15 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DHX15 34 35
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia DHX15 34 35
  • 96.06 (n)
cow
(Bos Taurus)
Mammalia DHX15 34 35
  • 95.51 (n)
rat
(Rattus norvegicus)
Mammalia Dhx15 34
  • 93.42 (n)
mouse
(Mus musculus)
Mammalia Dhx15 34 16 35
  • 93.21 (n)
chicken
(Gallus gallus)
Aves DHX15 34 35
  • 85.39 (n)
lizard
(Anolis carolinensis)
Reptilia DHX15 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx15 34
  • 80.39 (n)
Str.8082 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.5587 34
zebrafish
(Danio rerio)
Actinopterygii dhx15 34 35
  • 73.86 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8963 34
fruit fly
(Drosophila melanogaster)
Insecta CG11107 34 35
  • 67.23 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011149 34
  • 65.87 (n)
worm
(Caenorhabditis elegans)
Secernentea F56D2.6 34 35
  • 65.32 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP43 34 35 37
  • 64.07 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B00561g 34
  • 61.47 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR180C 34
  • 60.84 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G62310 34
  • 66.43 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9698 34
rice
(Oryza sativa)
Liliopsida Os03g0314100 34
  • 65.85 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes prp43 34
  • 61.65 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01612 34
  • 58.73 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5594 34
Species where no ortholog for DHX15 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHX15 Gene

ENSEMBL:
Gene Tree for DHX15 (if available)
TreeFam:
Gene Tree for DHX15 (if available)

Paralogs for DHX15 Gene

Paralogs for DHX15 Gene

(9) SIMAP similar genes for DHX15 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DHX15: view

Variants for DHX15 Gene

Sequence variations from dbSNP and Humsavar for DHX15 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10007870 -- 24,543,774(+) TATAA(C/T)TTTTT intron-variant
rs10008652 -- 24,547,579(+) CAATG(A/G)TAAAC intron-variant
rs10008876 -- 24,547,943(+) TATAT(A/C)TATAT intron-variant
rs10011177 -- 24,574,979(+) aaacc(C/T)caact intron-variant
rs10017492 -- 24,555,972(+) GGGTA(C/G)AGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHX15 Gene

Variant ID Type Subtype PubMed ID
dgv5157n100 CNV gain 25217958
nsv1136825 CNV deletion 24896259
nsv289788 CNV deletion 16902084
nsv950559 CNV duplication 24416366

Variation tolerance for DHX15 Gene

Residual Variation Intolerance Score: 7.59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHX15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DHX15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX15 Gene

Disorders for DHX15 Gene

Relevant External Links for DHX15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHX15

No disorders were found for DHX15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX15 Gene

Publications for DHX15 Gene

  1. Cloning and characterization of a putative human RNA helicase gene of the DEAH-box protein family. (PMID: 9388478) Imamura O. … Furuichi Y. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 64
  2. Isolation and characterization of post-splicing lariat-intron complexes. (PMID: 19103666) Yoshimoto R. … Ohno M. (Nucleic Acids Res. 2009) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PMID: 15146077) Will C.L. … Luehrmann R. (RNA 2004) 3 4 64
  5. The human La (SS-B) autoantigen interacts with DDX15/hPrp43, a putative DEAH-box RNA helicase. (PMID: 12458796) Fouraux M.A. … Pruijn G.J.M. (RNA 2002) 3 4 64

Products for DHX15 Gene

Sources for DHX15 Gene

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