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Aliases for DHX15 Gene

Aliases for DHX15 Gene

  • DEAH-Box Helicase 15 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 15 2 3
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 15 2 3
  • DEAH (Asp-Glu-Ala-His) Box Helicase 15 2 3
  • ATP-Dependent RNA Helicase #46 3 4
  • DEAH Box Protein 15 3 4
  • DDX15 3 4
  • DBP1 3 4
  • Putative Pre-MRNA-Splicing Factor ATP-Dependent RNA Helicase DHX15 3
  • Pre-MRNA-Splicing Factor ATP-Dependent RNA Helicase DHX15 3
  • RNA Helicase 2 3
  • DEAD/H Box-15 3
  • EC 3.6.4.13 4
  • EC 3.6.1 58
  • PrPp43p 3
  • PRPF43 3
  • PRP43 3
  • HRH2 3

External Ids for DHX15 Gene

Previous HGNC Symbols for DHX15 Gene

  • DDX15

Previous GeneCards Identifiers for DHX15 Gene

  • GC04M024217
  • GC04M024279
  • GC04M024205
  • GC04M024138
  • GC04M024529
  • GC04M023871

Summaries for DHX15 Gene

Entrez Gene Summary for DHX15 Gene

  • The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing. [provided by RefSeq, Jul 2008]

GeneCards Summary for DHX15 Gene

DHX15 (DEAH-Box Helicase 15) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DHX32.

UniProtKB/Swiss-Prot for DHX15 Gene

  • Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns.

Gene Wiki entry for DHX15 Gene

Additional gene information for DHX15 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX15 Gene

Genomics for DHX15 Gene

Regulatory Elements for DHX15 Gene

Enhancers for DHX15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H024469 1.6 FANTOM5 Ensembl ENCODE 28 +112.9 112907 4 ATF1 FEZF1 GLI4 ZNF2 ZNF121 ZNF766 GLIS2 FOS KLF7 ZNF548 DHX15 ZCCHC4 ANAPC4 MIR573 LINC02473 PPARGC1A GC04P024448
GH04H024657 1.3 Ensembl ENCODE dbSUPER 22.9 -74.5 -74469 2 FOXA2 MAX ZIC2 RBAK ZNF366 POLR2A ZSCAN5C RUNX3 IKZF2 ZBTB20 ANAPC4 DHX15 LINC02473 ZCCHC4 LGI2 ATP5LP3
GH04H025312 1.1 ENCODE 25.8 -728.5 -728465 1 HDGF MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ANAPC4 DHX15 ZCCHC4 PI4K2B PIR58322
GH04H024642 0.8 Ensembl ENCODE 17.8 -58.9 -58852 1 JUND TEAD1 FOS ZBTB40 ATF2 TEAD3 DHX15 LINC02473 GC04M024658
GH04H024687 0.7 ENCODE 19.6 -102.7 -102747 0 CTCF PKNOX1 ATF1 RB1 TRIM22 ZNF384 REST RAD21 GATA3 GATA2 DHX15 MIR573 SOD3 LINC02473 PIR57270
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DHX15 on UCSC Golden Path with GeneCards custom track

Promoters for DHX15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000166805 703 2601 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766

Genomic Location for DHX15 Gene

Chromosome:
4
Start:
24,517,441 bp from pter
End:
24,584,603 bp from pter
Size:
67,163 bases
Orientation:
Minus strand

Genomic View for DHX15 Gene

Genes around DHX15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX15 Gene

Proteins for DHX15 Gene

  • Protein details for DHX15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43143-DHX15_HUMAN
    Recommended name:
    Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
    Protein Accession:
    O43143
    Secondary Accessions:
    • Q9NQT7

    Protein attributes for DHX15 Gene

    Size:
    795 amino acids
    Molecular mass:
    90933 Da
    Quaternary structure:
    • Interacts with SSB/La (PubMed:12458796). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome (PubMed:15146077). Identified in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors; the association may be transient. Interacts with TFIP11; indicative for a recruitment to the IL complex (PubMed:19103666). Interacts with GPATCH2 (PubMed:19432882).

    Three dimensional structures from OCA and Proteopedia for DHX15 Gene

neXtProt entry for DHX15 Gene

Selected DME Specific Peptides for DHX15 Gene

O43143:
  • GYFMQVAHLERTGHYLTVKDNQVV
  • LDEAHERT
  • QWCYDNFI
  • RVESLLV
  • FLTGQEE
  • DYLEAAIRTVIQIHM
  • TYPEILRSNLGSVVLQLKKLG
  • LYNEFVLTTKN
  • LHPSTVLDHKPEW
  • LKVIVMSAT
  • MSATLDAGKFQ
  • EPERDYLEAA
  • TQPRRVAA
  • TNIAETS
  • VGYSIRF
  • EFPLDPQL
  • FDFMDPP
  • TDGMLLRE
  • MDPPAPET
  • DEAHERTL
  • IAPQYYD
  • HPVEIFYT
  • ADEAKMRFAHIDGDHLTLLNVYHAFKQN
  • LKKLGIDDLVHFD
  • DPGFAKQ
  • EACKRIKREVD
  • HSAHSTH
  • GKTTQIPQ
  • RSDLKVI
  • LGQEVGY
  • EMQDNTYPEILRSNLG
  • TGSGKTTQ

Post-translational modifications for DHX15 Gene

  • Ubiquitination at posLast=143143, isoforms=230, isoforms=234, posLast=463463, isoforms=491, and isoforms=790
  • Modification sites at PhosphoSitePlus

Other Protein References for DHX15 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for DHX15 Gene

Gene Families for DHX15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DHX15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43143

UniProtKB/Swiss-Prot:

DHX15_HUMAN :
  • Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.
genes like me logo Genes that share domains with DHX15: view

Function for DHX15 Gene

Molecular function for DHX15 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns.

Enzyme Numbers (IUBMB) for DHX15 Gene

Phenotypes From GWAS Catalog for DHX15 Gene

Gene Ontology (GO) - Molecular Function for DHX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA 22658674
GO:0003724 RNA helicase activity TAS 7935475
GO:0003725 double-stranded RNA binding IDA 21266579
GO:0004004 ATP-dependent RNA helicase activity IBA --
genes like me logo Genes that share ontologies with DHX15: view
genes like me logo Genes that share phenotypes with DHX15: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DHX15
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHX15 Gene

Localization for DHX15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX15 Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHX15 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DHX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9388478
GO:0005654 nucleoplasm TAS --
GO:0005689 U12-type spliceosomal complex IDA 15146077
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DHX15: view

Pathways & Interactions for DHX15 Gene

genes like me logo Genes that share pathways with DHX15: view

Pathways by source for DHX15 Gene

1 KEGG pathway for DHX15 Gene

Gene Ontology (GO) - Biological Process for DHX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing TAS 7935475
GO:0008380 RNA splicing IC 15146077
GO:0009636 response to toxic substance IEA --
GO:0043279 response to alkaloid IEA --
genes like me logo Genes that share ontologies with DHX15: view

No data available for SIGNOR curated interactions for DHX15 Gene

Drugs & Compounds for DHX15 Gene

(3) Drugs for DHX15 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Nutra Agonist 0

(1) Additional Compounds for DHX15 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DHX15: view

Transcripts for DHX15 Gene

Unigene Clusters for DHX15 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DHX15
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DHX15 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c ^
SP1: -
SP2: - -
SP3:
SP4: -
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12:
SP13: - - -
SP14: -
SP15:
SP16:

ExUns: 16a · 16b · 16c ^ 17a · 17b · 17c ^ 18a · 18b · 18c · 18d
SP1:
SP2: - -
SP3:
SP4: -
SP5: - -
SP6: - -
SP7:
SP8:
SP9: - -
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15: - - -
SP16:

Relevant External Links for DHX15 Gene

GeneLoc Exon Structure for
DHX15
ECgene alternative splicing isoforms for
DHX15

Expression for DHX15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHX15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DHX15 Gene

This gene is overexpressed in Lymph node (9.2) and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DHX15 Gene



Protein tissue co-expression partners for DHX15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DHX15 Gene:

DHX15

SOURCE GeneReport for Unigene cluster for DHX15 Gene:

Hs.696074

mRNA Expression by UniProt/SwissProt for DHX15 Gene:

O43143-DHX15_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for DHX15 Gene

  • Liver(4.4)
  • Nervous system(4.4)
  • Lung(3.2)
  • Blood(2.7)
  • Kidney(2.7)
  • Heart(2.1)
  • Bone marrow(2)
  • Eye(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with DHX15: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHX15 Gene

Orthologs for DHX15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX15 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia DHX15 34
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DHX15 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DHX15 33 34
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia DHX15 33 34
  • 96.06 (n)
cow
(Bos Taurus)
Mammalia DHX15 33 34
  • 95.51 (n)
rat
(Rattus norvegicus)
Mammalia Dhx15 33
  • 93.42 (n)
mouse
(Mus musculus)
Mammalia Dhx15 33 16 34
  • 93.21 (n)
chicken
(Gallus gallus)
Aves DHX15 33 34
  • 85.39 (n)
lizard
(Anolis carolinensis)
Reptilia DHX15 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx15 33
  • 80.39 (n)
Str.8082 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.5587 33
zebrafish
(Danio rerio)
Actinopterygii dhx15 33 34
  • 73.86 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8963 33
fruit fly
(Drosophila melanogaster)
Insecta CG11107 33 34
  • 67.23 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011149 33
  • 65.87 (n)
worm
(Caenorhabditis elegans)
Secernentea F56D2.6 33 34
  • 65.32 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP43 33 34 36
  • 64.07 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B00561g 33
  • 61.47 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR180C 33
  • 60.84 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G62310 33
  • 66.43 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9698 33
rice
(Oryza sativa)
Liliopsida Os03g0314100 33
  • 65.85 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes prp43 33
  • 61.65 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01612 33
  • 58.73 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5594 33
Species where no ortholog for DHX15 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHX15 Gene

ENSEMBL:
Gene Tree for DHX15 (if available)
TreeFam:
Gene Tree for DHX15 (if available)

Paralogs for DHX15 Gene

Paralogs for DHX15 Gene

(9) SIMAP similar genes for DHX15 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DHX15: view

Variants for DHX15 Gene

Sequence variations from dbSNP and Humsavar for DHX15 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000060729 -- 24,542,731(+) ACTCT(A/G)AAAGA intron-variant
rs1000075360 -- 24,569,499(+) AGGCA(A/G)GAGAA intron-variant
rs1000098598 -- 24,529,040(+) TATGT(C/T)TGAGA intron-variant
rs1000104447 -- 24,557,218(+) CTGTC(C/T)ATTCC intron-variant
rs1000173526 -- 24,528,907(+) ACAAA(A/C)CAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHX15 Gene

Variant ID Type Subtype PubMed ID
dgv5157n100 CNV gain 25217958
nsv1136825 CNV deletion 24896259
nsv289788 CNV deletion 16902084
nsv950559 CNV duplication 24416366

Variation tolerance for DHX15 Gene

Residual Variation Intolerance Score: 7.59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHX15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DHX15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX15 Gene

Disorders for DHX15 Gene

Relevant External Links for DHX15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHX15

No disorders were found for DHX15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX15 Gene

Publications for DHX15 Gene

  1. Cloning and characterization of a putative human RNA helicase gene of the DEAH-box protein family. (PMID: 9388478) Imamura O … Furuichi Y (Biochemical and biophysical research communications 1997) 2 3 4 60
  2. Isolation and characterization of post-splicing lariat-intron complexes. (PMID: 19103666) Yoshimoto R … Ohno M (Nucleic acids research 2009) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PMID: 15146077) Will CL … Lührmann R (RNA (New York, N.Y.) 2004) 3 4 60
  5. The human La (SS-B) autoantigen interacts with DDX15/hPrp43, a putative DEAH-box RNA helicase. (PMID: 12458796) Fouraux MA … Pruijn GJ (RNA (New York, N.Y.) 2002) 3 4 60

Products for DHX15 Gene

Sources for DHX15 Gene

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