Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DHX15 Gene

protein-coding   GIFtS: 59
GCID: GC04M024519

DEAH (Asp-Glu-Ala-His) Box Helicase 15

(Previous names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 15, DEAH (Asp-Glu-Ala-His)...)
(Previous symbol: DDX15)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
DEAH (Asp-Glu-Ala-His) Box Helicase 151 2     PRP432
DDX151 2 3 5     PRPF432
DBP12 3 5     PrPp43p2
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 151 2     DEAD/H Box-152
DEAH (Asp-Glu-Ala-His) Box Polypeptide 151 2     Putative Pre-MRNA-Splicing Factor ATP-Dependent RNA Helicase DHX152
ATP-Dependent RNA Helicase #462 3     RNA Helicase 22
DEAH Box Protein 152 3     EC 3.6.4.133
HRH22 5     EC 3.6.18

External Ids:    HGNC: 27381   Entrez Gene: 16652   Ensembl: ENSG000001096067   OMIM: 6034035   UniProtKB: O431433   

Export aliases for DHX15 gene to outside databases

Previous GC identifers: GC04M024217 GC04M024279 GC04M024205 GC04M024138 GC04M024529 GC04M023871


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DHX15 Gene:
The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing.
(provided by RefSeq, Jul 2008)

GeneCards Summary for DHX15 Gene:
DHX15 (DEAH (Asp-Glu-Ala-His) box helicase 15) is a protein-coding gene. GO annotations related to this gene include RNA helicase activity and nucleic acid binding. An important paralog of this gene is DHX33.

UniProtKB/Swiss-Prot: DHX15_HUMAN, O43143
Function: Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In
cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to
the snRNP-free IS complex leading to efficient debranching and turnover of excised introns

summary for DHX15 Gene:
Histamine H2 receptors are Galphas-protein-coupled receptors involved in the suppressive activities of
histamine. H2 receptors exhibit a widespread distribution and are found in the gastrointestinal tract, the
central nervous system, smooth muscle cells, endothelial cells, cardiomyocytes, immune cells and more. H2
receptors regulate various functions of histamine including heart contraction, gastric acid secretion, cell
proliferation and differentiation, and immune responses. In the immune system, H2 activation negatively
regulates basophils and mast cells, and inhibits antibody synthesis, T cell production, cell-mediated
cytolysis and cytokine production. H2 receptors are present on Th2 cells and activation increases the
synthesis of cytokines such as IL-4, Il-5, Il-10 and IL-13. Furthermore, histamine-induced T cell suppressor
activity is mediated through H2 receptors. Due to their role in gastric acid secretion, H2 receptor
overactivity is a cause of gastric ulcers, and pharmacological inhibition of these receptors is an effective
treatment for this condition. The human gene encoding the H2 receptor is localized to chromosome 5q35.3.

Gene Wiki entry for DHX15 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the DHX15 gene promoter:
         FOXF2   GATA-3   SREBP-1c   GATA-1   GATA-2   Max   HFH-1   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDHX15 promoter sequence
   Search Chromatin IP Primers for DHX15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DHX15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15.3   Ensembl cytogenetic band:  4p15.2   HGNC cytogenetic band: 4p15.3

DHX15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHX15 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M024519:  view genomic region     (about GC identifiers)

Start:
24,519,064 bp from pter      End:
24,586,184 bp from pter
Size:
67,121 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DHX15_HUMAN, O43143 (See protein sequence)
Recommended Name: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15  
Size: 795 amino acids; 90933 Da
Subunit: Interacts with SSB/La. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.
Identified in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised
intron, U2, U5 and U6 snRNPs, and splicing factors; the association may be transient. Interacts with TFIP11;
indicative for a recruitment to the IL complex
Secondary accessions: Q9NQT7

Explore the universe of human proteins at neXtProt for DHX15: NX_O43143

Explore proteomics data for DHX15 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys143, Lys230, Lys234, Lys463, Lys491, Lys790
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DHX15 (O43143) (see all 32)
     TNIAETS  VGYSIRF  FDFMDPP  RVESLLV 


    See DHX15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001349.2  
    ENSEMBL proteins: 
     ENSP00000336741  

    DHX15 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DHX15
    OriGene Protein Over-expression Lysate for DHX15
    OriGene MassSpec for DHX15
    OriGene Custom Protein Services for DHX15
    GenScript Custom Purified and Recombinant Proteins Services for DHX15
    Novus Biologicals DHX15 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DHX15

     
    Search eBioscience for Proteins for DHX15 

    DHX15 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DHX15
    Novus Biologicals DHX15 Antibodies
    Abcam antibodies for DHX15
    Cloud-Clone Corp. Antibodies for DHX15
    ThermoFisher Antibodies for DHX15
    LSBio Antibodies in human, mouse, rat for DHX15

    DHX15 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DHX15
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DHX15
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DHX15
    Cloud-Clone Corp. CLIAs for DHX15
    Search eBioscience for ELISAs for DHX15 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    DHX: DEAH-boxes

    Selected InterPro protein domains (see all 8):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR002464 DNA/RNA_helicase_DEAH_CS
     IPR007502 Helicase-assoc_dom
     IPR011709 DUF1605
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry O43143

    ProtoNet protein and cluster: O43143

    2 Blocks protein domains:
    IPB002464 ATP-dependent helicase
    IPB007502 Helicase-associated region


    UniProtKB/Swiss-Prot: DHX15_HUMAN, O43143
    Similarity: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Find genes that share domains with DHX15           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DHX15_HUMAN, O43143
    Function: Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In
    cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to
    the snRNP-free IS complex leading to efficient debranching and turnover of excised introns
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003724RNA helicase activity TAS7935475
    GO:0003725double-stranded RNA binding IDA--
    GO:0004386helicase activity ----
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with DHX15           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DHX15:
     Nucleolar pre-40S maturation d  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DHX15
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DHX15

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DHX15
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DHX15

    miRNA
    Products:
        
    miRTarBase miRNAs that target DHX15:
    hsa-mir-221-3p (MIRT046931), hsa-mir-378a-3p (MIRT043871), hsa-mir-26a-5p (MIRT050083), hsa-mir-484 (MIRT041781), hsa-let-7e-5p (MIRT051549), hsa-mir-1 (MIRT002740)

    Block miRNA regulation of human, mouse, rat DHX15 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DHX15 (see all 48):
    hsa-miR-1321 hsa-miR-3607-3p hsa-miR-607 hsa-miR-139-5p hsa-miR-650 hsa-miR-4275 hsa-miR-186 hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidDHX15 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DHX15
    Predesigned siRNA for gene silencing in human, mouse, rat DHX15

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DHX15

    Clone
    Products:
         
    OriGene clones in human, mouse for DHX15 (see all 7)
    OriGene ORF clones in mouse, rat for DHX15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DHX15 (NM_001358)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHX15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX15

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DHX15
    Browse ESI BIO Cell Lines and PureStem Progenitors for DHX15 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX15


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DHX15_HUMAN, O43143: Nucleus. Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005689U12-type spliceosomal complex IDA15146077
    GO:0005730nucleolus IEA--
    GO:0071008colocalizes with U2-type post-mRNA release spliceosomal complex IDA19103666

    Find genes that share ontologies with DHX15           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for DHX15 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA processing0.44
    2Spliceosome
    Spliceosome


    Find genes that share SuperPaths with DHX15           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for DHX15
        mRNA processing


    1 Kegg Pathway  (Kegg details for DHX15):
        Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DHX15
    Interactions:

        GeneGlobe Interaction Network for DHX15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DHX15 (O431431, 2, 3 ENSP000003367414) via UniProtKB, MINT, STRING, and/or I2D (see all 576)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBM5P527561, 2, ENSP000003430544EBI-1237044,EBI-714003 MINT-8328618 MINT-8328286 MINT-8328168 MINT-8328357 MINT-8328000 MINT-8328306 MINT-8328264 MINT-8328195 MINT-8328330 MINT-8332218 MINT-8328060 MINT-8328016 MINT-8328178 MINT-8334010 STRING: ENSP00000343054
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IC15146077

    Find genes that share ontologies with DHX15           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for DHX15 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    HTMT dimaleateH1 / H2 agonist[195867-54-0]
    Amthamine dihydrobromideHighly selective standard H2 agonist[142437-67-0]
    Dimaprit dihydrochlorideStandard H2 selective agonist[23256-33-9]
    Zolantidine dimaleate Potent, centrally active H2 antagonist [104076-38-2]
    Tiotidine Potent, selective H2 antagonist [69014-14-8]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DHX15 gene: 
    NM_001358.2  

    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000510645 ENST00000508032(uc003gqw.3) ENST00000336812(uc003gqx.3)
    ENST00000513036 ENST00000512903(uc003gqv.3) ENST00000508368 ENST00000504279
    ENST00000503562 ENST00000511553 ENST00000513092
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DHX15 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DHX15 (see all 48):
    hsa-miR-1321 hsa-miR-3607-3p hsa-miR-607 hsa-miR-139-5p hsa-miR-650 hsa-miR-4275 hsa-miR-186 hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidDHX15 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DHX15
    Predesigned siRNA for gene silencing in human, mouse, rat DHX15
    Clone
    Products:
         
    OriGene clones in human, mouse for DHX15 (see all 7)
    OriGene ORF clones in mouse, rat for DHX15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DHX15 (NM_001358)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHX15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX15
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DHX15
    OriGene qSTAR qPCR primer pairs in human, mouse for DHX15
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DHX15
      QuantiTect SYBR Green Assays in human, mouse, rat DHX15
      QuantiFast Probe-based Assays in human, mouse, rat DHX15

    Selected AceView cDNA sequences (see all 417):

    AA722883 BQ024155 CB215697 BM828945 BC035974 CD172319 BM718919 AA831068 
    CR605943 CB118587 BQ222039 BF792333 AI151266 AA780336 BG288849 BM353047 
    BU734747 AA249109 BQ927663 BF194873 AA693400 BQ723226 BE217962 BE783634 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DHX15 (see all 16)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c ^
    SP1:                                                                                                                                            -               
    SP2:                                                                                                                                            -     -         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                            -               
    SP5:                                                                                                                                            -               

    ExUns: 16a · 16b · 16c ^ 17a · 17b · 17c ^ 18a · 18b · 18c · 18d
    SP1:                                                            
    SP2:  -                 -                                       
    SP3:                                                            
    SP4:  -                                                         
    SP5:  -                 -                                       


    ECgene alternative splicing isoforms for DHX15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DHX15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCGTTGTAA
    DHX15 Expression
    About this image


    DHX15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Lung (Respiratory System)
    DHX15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DHX15 Protein Expression

    UniProtKB/Swiss-Prot: DHX15_HUMAN, O43143
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for DHX15
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DHX15
    OriGene qSTAR qPCR primer pairs in human, mouse for DHX15
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DHX15
    QuantiTect SYBR Green Assays in human, mouse, rat DHX15
    QuantiFast Probe-based Assays in human, mouse, rat DHX15
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DHX15 gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dhx151 , 5 DEAH (Asp-Glu-Ala-His) box polypeptide 151, 5 93.21(n)1
    99.62(a)1
      5 (27.51 cM)5
    132041  NM_007839.31  NP_031865.21 
     521502095 
    chicken
    (Gallus gallus)
    Aves DHX151 DEAH (Asp-Glu-Ala-His) box polypeptide 15 85.39(n)
    95.41(a)
      422813  NM_001031159.1  NP_001026330.1 
    lizard
    (Anolis carolinensis)
    Reptilia DHX156
    DEAH (Asp-Glu-Ala-His) box helicase 15
    95(a)
    1 ↔ 1
    5(73432807-73471738)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.55872 Xenopus laevis transcribed sequence with strong similarity more 82.91(n)    CB206540.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC048369.12   -- 74.89(n)    BC048369.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG111071 CG11107 67.23(n)
    78.78(a)
      35654  NM_136425.3  NP_610269.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F56D2.61 F56D2.6 65.32(n)
    73.4(a)
      175771  NM_171130.4  NP_741147.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRP43(YGL120C)4
    PRP431
    RNA helicase in the DEAH-box family, functions in both more4
    PRP431
    64.07(n)1
    67.07(a)1
      7(283937-281634)4
    8527571, 4  NP_011395.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G623101 AT3G62310 66.43(n)
    71.04(a)
      825404  NM_116096.4  NP_191790.1 
    rice
    (Oryza sativa)
    Liliopsida AK064890.12   -- 73.72(n)    AK064890.1 


    ENSEMBL Gene Tree for DHX15 (if available)
    TreeFam Gene Tree for DHX15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DHX15 gene
    DHX332  DHX162  DHX352  DQX12  DHX322  DHX82  
    9 SIMAP similar genes for DHX15 using alignment to 1 protein entry:     DHX15_HUMAN:
    DHX8    DHX16    DHX35    DHX32    DHX38    DHX33
    DHX34    DHX40    DQX1

    Find genes that share paralogs with DHX15           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DHX15 (see all 1190)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1867053551,2
    --24528719(+) TAAACC/GTGTTT 1 -- ds50010--------
    rs1912146211,2
    --24528772(+) TTAATA/GAATTA 1 -- ds50010--------
    rs168757421,2
    C,F,H--24528892(+) TAGATC/TGATCA 1 -- ds500111Minor allele frequency- T:0.06NA NS EA WA 802
    rs1502271031,2
    C--24528893(+) AGATCA/GATCAC 1 -- ds50010--------
    rs1386918811,2
    --24528930(+) AGCCAC/TGCTCT 1 -- ds50010--------
    rs168757441,2
    C,F,H--24529056(+) CTATAC/TTTAGA 1 -- ds500119Minor allele frequency- T:0.06NA NS EA WA 2270
    rs1826264961,2
    --24529076(+) AAAGAC/TACCAA 1 -- ds50010--------
    rs1869939361,2
    --24529134(+) CCTCTC/GTACTG 1 -- ut310--------
    rs717303241,2
    C--24529407(+) AATGG-/AATA  
            
    TTTAC
    1 -- ut310--------
    rs1931932261,2
    --24529416(+) TTTACC/TGTAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DHX15 (24519064 - 24586184 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DHX15:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv289788CNV Loss16902084

    Human Gene Mutation Database (HGMD): DHX15
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DHX15
    DNA2.0 Custom Variant and Variant Library Synthesis for DHX15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603403    OMIM disorders: --


    Find genes that share disorders with DHX15           About GenesLikeMe


    Export disorders for DHX15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DHX15 gene, integrated from 10 sources (see all 67):
    (articles sorted by number of sources associating them with DHX15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a putative human RNA helicase gene of the DEAH-box protein family. (PubMed id 9388478)1, 2, 3 Imamura O.... Furuichi Y. (Biochem. Biophys. Res. Commun. 1997)
    2. Isolation and characterization of post-splicing lariat-intron complexes. (PubMed id 19103666)1, 2 Yoshimoto R.... Ohno M. (Nucleic Acids Res. 2009)
    3. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PubMed id 15146077)1, 2 Will C.L.... Luehrmann R. (RNA 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The human La (SS-B) autoantigen interacts with DDX15/hPrp43, a putative DEAH-box RNA helicase. (PubMed id 12458796)1, 2 Fouraux M.A.... Pruijn G.J.M. (RNA 2002)
    6. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    7. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)
    8. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1665 HGNC: 2738 AceView: DHX15 Ensembl:ENSG00000109606 euGenes: HUgn1665
    ECgene: DHX15 Kegg: 1665 H-InvDB: DHX15

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DHX15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DHX15 gene:
    Search GeneIP for patents involving DHX15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DHX15  
     OriGene qPCR primer pairs and template standards for DHX15   OriGene Protein Over-expression Lysate for DHX15  
     OriGene MassSpec something-or-other for DHX15   OriGene clones in human, mouse for DHX15  
     OriGene qSTAR qPCR primer pairs in human, mouse for DHX15   OriGene Purified Protein for DHX15  
     OriGene ORF clones in mouse, rat for DHX15   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DHX15   OriGene Custom Protein Services for DHX15  

     
     
     Block miRNA regulation of human, mouse, rat DHX15 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DHX15
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DHX15 Predesigned siRNA for gene silencing in human, mouse, rat DHX15
     QuantiFast Probe-based Assays in human, mouse, rat DHX15 QuantiTect SYBR Green Assays in human, mouse, rat DHX15
     Custom PCR Arrays for DHX15 Search Chromatin IP Primers for DHX15
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DHX15  GeneGlobe Interaction Network for DHX15
     Regulatory tfbs in DHX15 promoter
     GenScript Custom Purified and Recombinant Proteins Services for DHX15 GenScript cDNA clones with any tag delivered in your preferred vector for DHX15
     GenScript Custom Assay Services for DHX15 GenScript Custom overexpressing Cell Line Services for DHX15
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for DHX15
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DHX15 antibodies
     DHX15 lysates
     Antibodies for DHX15
     See all of Abcam's Antibodies, Kits and Proteins for DHX15
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for DHX15
     Antibodies for DHX15
     ELISAs for DHX15
     CLIAs for DHX15



     Browse ESI BIO Cell Lines and PureStem Progenitors for DHX15
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX15
     SwitchGear 3'UTR luciferase reporter plasmids for DHX15
     SwitchGear Promoter luciferase reporter plasmids for DHX15
     ThermoFisher Antibodies for DHX15
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX15
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DHX15
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DHX15
     LSBio Antibodies in human, mouse, rat for DHX15
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for DHX15
      Search eBioscience for proteins for DHX15
      Search eBioscience for elisas for DHX15
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DHX15 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4