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Aliases for DHX15 Gene

Aliases for DHX15 Gene

  • DEAH (Asp-Glu-Ala-His) Box Helicase 15 2 3
  • DDX15 3 4 6
  • DBP1 3 4 6
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 15 2 3
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 15 2 3
  • ATP-Dependent RNA Helicase #46 3 4
  • DEAH Box Protein 15 3 4
  • HRH2 3 6
  • Putative Pre-MRNA-Splicing Factor ATP-Dependent RNA Helicase DHX15 3
  • RNA Helicase 2 3
  • DEAD/H Box-15 3
  • EC 3.6.4.13 4
  • EC 3.6.1 64
  • PrPp43p 3
  • PRPF43 3
  • PRP43 3

External Ids for DHX15 Gene

Previous Symbols for DHX15 Gene

  • DDX15

Summaries for DHX15 Gene

Entrez Gene Summary for DHX15 Gene

  • The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing. [provided by RefSeq, Jul 2008]

GeneCards Summary for DHX15 Gene

DHX15 (DEAH (Asp-Glu-Ala-His) Box Helicase 15) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include nucleic acid binding and RNA helicase activity. An important paralog of this gene is DHX35.

UniProtKB/Swiss-Prot for DHX15 Gene

  • Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns.

Gene Wiki entry for DHX15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX15 Gene

Genomics for DHX15 Gene

Genomic Location for DHX15 Gene

Start:
24,517,441 bp from pter
End:
24,584,561 bp from pter
Size:
67,121 bases
Orientation:
Minus strand

Genomic View for DHX15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHX15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX15 Gene

Regulatory Elements for DHX15 Gene

Proteins for DHX15 Gene

  • Protein details for DHX15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43143-DHX15_HUMAN
    Recommended name:
    Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
    Protein Accession:
    O43143
    Secondary Accessions:
    • Q9NQT7

    Protein attributes for DHX15 Gene

    Size:
    795 amino acids
    Molecular mass:
    90933 Da
    Quaternary structure:
    • Interacts with SSB/La (PubMed:12458796). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome (PubMed:15146077). Identified in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors; the association may be transient. Interacts with TFIP11; indicative for a recruitment to the IL complex (PubMed:19103666). Interacts with GPATCH2 (PubMed:19432882).

neXtProt entry for DHX15 Gene

Proteomics data for DHX15 Gene at MOPED

Post-translational modifications for DHX15 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys143, Lys230, Lys234, Lys463, Lys491, and Lys790

Other Protein References for DHX15 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for DHX15 Gene

Gene Families for DHX15 Gene

HGNC:
  • DHX :DEAH-boxes

UniProtKB/Swiss-Prot:

DHX15_HUMAN
Domain:
  • Contains 1 helicase ATP-binding domain.:
    • O43143
  • Contains 1 helicase C-terminal domain.:
    • O43143
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.:
    • O43143
genes like me logo Genes that share domains with DHX15: view

Function for DHX15 Gene

Molecular function for DHX15 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function: Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns.

Enzyme Numbers (IUBMB) for DHX15 Gene

Gene Ontology (GO) - Molecular Function for DHX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003724 RNA helicase activity TAS 7935475
GO:0003725 double-stranded RNA binding IDA 21266579
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity --
genes like me logo Genes that share ontologies with DHX15: view

Phenotypes for DHX15 Gene

GenomeRNAi human phenotypes for DHX15:
genes like me logo Genes that share phenotypes with DHX15: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DHX15 Gene

Localization for DHX15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX15 Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHX15 Gene COMPARTMENTS Subcellular localization image for DHX15 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for DHX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005689 U12-type spliceosomal complex IDA 15146077
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DHX15: view

Pathways for DHX15 Gene

genes like me logo Genes that share pathways with DHX15: view

Gene Ontology (GO) - Biological Process for DHX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IBA --
GO:0006200 obsolete ATP catabolic process --
GO:0006397 mRNA processing TAS 7935475
GO:0008380 RNA splicing IC 15146077
genes like me logo Genes that share ontologies with DHX15: view

Transcripts for DHX15 Gene

Unigene Clusters for DHX15 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHX15 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c ^
SP1: -
SP2: - -
SP3:
SP4: -
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12:
SP13: - - -
SP14: -
SP15:
SP16:

ExUns: 16a · 16b · 16c ^ 17a · 17b · 17c ^ 18a · 18b · 18c · 18d
SP1:
SP2: - -
SP3:
SP4: -
SP5: - -
SP6: - -
SP7:
SP8:
SP9: - -
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15: - - -
SP16:

Relevant External Links for DHX15 Gene

GeneLoc Exon Structure for
DHX15
ECgene alternative splicing isoforms for
DHX15

Expression for DHX15 Gene

mRNA expression in normal human tissues for DHX15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHX15 Gene

SOURCE GeneReport for Unigene cluster for DHX15 Gene Hs.696074

mRNA Expression by UniProt/SwissProt for DHX15 Gene

O43143-DHX15_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with DHX15: view

Orthologs for DHX15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHX15 36
  • 99.71 (n)
  • 100 (a)
DHX15 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DHX15 36
  • 95.51 (n)
  • 99.75 (a)
DHX15 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DHX15 36
  • 96.06 (n)
  • 99.75 (a)
DHX15 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dhx15 36
  • 93.21 (n)
  • 99.62 (a)
Dhx15 16
Dhx15 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DHX15 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DHX15 37
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dhx15 36
  • 93.42 (n)
  • 99.75 (a)
chicken
(Gallus gallus)
Aves DHX15 36
  • 85.39 (n)
  • 95.41 (a)
DHX15 37
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHX15 37
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5587 36
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx15 36
  • 80.39 (n)
  • 92.11 (a)
Str.8082 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8963 36
zebrafish
(Danio rerio)
Actinopterygii dhx15 36
  • 73.86 (n)
  • 91.37 (a)
dhx15 37
  • 92 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011149 36
  • 65.87 (n)
  • 79.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11107 36
  • 67.23 (n)
  • 78.78 (a)
CG11107 37
  • 78 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F56D2.6 36
  • 65.32 (n)
  • 73.4 (a)
F56D2.6 37
  • 73 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR180C 36
  • 60.84 (n)
  • 66.52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP43 36
  • 64.07 (n)
  • 67.07 (a)
PRP43 37
  • 59 (a)
OneToMany
PRP43 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B00561g 36
  • 61.47 (n)
  • 64.26 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9698 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G62310 36
  • 66.43 (n)
  • 71.04 (a)
rice
(Oryza sativa)
Liliopsida Os03g0314100 36
  • 65.85 (n)
  • 70.76 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01612 36
  • 58.73 (n)
  • 64.59 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes prp43 36
  • 61.65 (n)
  • 65.21 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5594 36
Species with no ortholog for DHX15:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHX15 Gene

ENSEMBL:
Gene Tree for DHX15 (if available)
TreeFam:
Gene Tree for DHX15 (if available)

Paralogs for DHX15 Gene

Paralogs for DHX15 Gene

Selected SIMAP similar genes for DHX15 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DHX15: view

Variants for DHX15 Gene

Sequence variations from dbSNP and Humsavar for DHX15 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs13772 -- 24,527,946(+) CCTTG(A/G)ATTGA reference, missense
rs1012231 -- 24,534,582(-) GGGTG(A/G)TTTAC intron-variant
rs1032922 -- 24,534,535(+) ACTGG(A/G)AACAT intron-variant
rs1062681 -- 24,576,468(-) CATTC(A/T)ACACA reference, synonymous-codon
rs1062682 -- 24,532,993(-) TCCGC(A/G)GACAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for DHX15 Gene

Variant ID Type Subtype PubMed ID
nsv289788 CNV Loss 16902084

Relevant External Links for DHX15 Gene

HapMap Linkage Disequilibrium report
DHX15

Disorders for DHX15 Gene

No disorders were found for DHX15 Gene.

No data available for UniProtKB/Swiss-Prot for DHX15 Gene

Publications for DHX15 Gene

  1. Cloning and characterization of a putative human RNA helicase gene of the DEAH-box protein family. (PMID: 9388478) Imamura O. … Furuichi Y. (Biochem. Biophys. Res. Commun. 1997) 2 3 4
  2. The human La (SS-B) autoantigen interacts with DDX15/hPrp43, a putative DEAH-box RNA helicase. (PMID: 12458796) Fouraux M.A. … Pruijn G.J.M. (RNA 2002) 3 4
  3. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PMID: 15146077) Will C.L. … Luehrmann R. (RNA 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Isolation and characterization of post-splicing lariat-intron complexes. (PMID: 19103666) Yoshimoto R. … Ohno M. (Nucleic Acids Res. 2009) 3 4

Products for DHX15 Gene

Sources for DHX15 Gene

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