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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DHRSX Gene

protein-coding   GIFtS: 45
GCID: GC0XM002147

Dehydrogenase/Reductase (SDR Family) X-Linked

(Previous name: dehydrogenase/reductase (SDR family) X chromosome)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dehydrogenase/Reductase (SDR Family) X-Linked1 2     Short Chain Dehydrogenase/Reductase Family 46C1
Dehydrogenase/Reductase (SDR Family) X Chromosome1 2     DHRS5Y2
Dehydrogenase/Reductase (SDR Family) Y-Linked1 2     DHRSY2
CXorf112 3     SDR46C12
DHRS5X2 3     Dehydrogenase/Reductase SDR Family Member On Chromosome X2
DHRSXY2 3     Short Chain Dehydrogenase/Reductase Family 46C, Member 12
Member 11     EC 1.1.-.-3

External Ids:    HGNC: 183991   Entrez Gene: 2070632   Ensembl: ENSG000001690847   UniProtKB: Q8N5I43   

Export aliases for DHRSX gene to outside databases

Previous GC identifers: GC0XM001605 GC0YU900009 GC00U921559 GC0XM000082


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DHRSX Gene: 
DHRSX (dehydrogenase/reductase (SDR family) X-linked) is a protein-coding gene. Diseases associated with DHRSX include tuberculosis, and gastric cancer. GO annotations related to this gene include oxidoreductase activity and nucleotide binding. An important paralog of this gene is ENSG00000258466.

Gene Wiki entry for DHRSX Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_167197.1  NC_000024.9  NT_167205.1  NC_018934.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for DHRSX
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for DHRSX

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHRSX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.33; Yp11.2   Ensembl cytogenetic band:  Xp22.33   HGNC cytogenetic band: Xp22.33 and Yp11

DHRSX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHRSX gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM002147:  view genomic region     (about GC identifiers)

Start:
2,137,547 bp from pter      End:
2,420,846 bp from pter
Size:
283,300 bases      Orientation:
minus strand

1 alternative location:
ChrY- 2,087,547-2,369,015     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DHRSX_HUMAN, Q8N5I4 (See protein sequence)
Recommended Name: Dehydrogenase/reductase SDR family member on chromosome X precursor  
Size: 330 amino acids; 36443 Da
Miscellaneous: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y
chromosomes
Secondary accessions: Q6UWC7 Q8WUS4 Q96GR8 Q9NTF6

Explore the universe of human proteins at neXtProt for DHRSX: NX_Q8N5I4

Explore proteomics data for DHRSX at MOPED 

DHRSX Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

DHRSX Protein Expression

REFSEQ proteins: NP_660160.2  
ENSEMBL proteins: 
 ENSP00000334113   ENSP00000391778   ENSP00000402741   ENSP00000403045   ENSP00000420788  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
PAR1: Pseudoautosomal regions / PAR1

4 InterPro protein domains:
 IPR020904 Sc_DH/Rdtase_CS
 IPR002347 Glc/ribitol_DH
 IPR002198 DH_sc/Rdtase_SDR
 IPR016040 NAD(P)-bd_dom

Graphical View of Domain Structure for InterPro Entry Q8N5I4

ProtoNet protein and cluster: Q8N5I4

2 Blocks protein domains:
IPB002198 Short-chain dehydrogenase/reductase SDR
IPB002347 Glucose/ribitol dehydrogenase family signature


UniProtKB/Swiss-Prot: DHRSX_HUMAN, Q8N5I4
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


DHRSX for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Enzyme Number (IUBMB): EC 1.1.-.-1

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003824catalytic activity ----
GO:0016491oxidoreductase activity IEA--
GO:0050662coenzyme binding ----
     
DHRSX for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for DHRSX:
 Increased G1 DNA content 

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section




Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DHRSX

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for DHRSX (ENSP000003341134) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
--ENSP000002678574STRING: ENSP00000267857
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008152metabolic process ----
GO:0044237cellular metabolic process ----

DHRSX for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
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Browse Tocris compounds for DHRSX

Search CenterWatch for drugs/clinical trials and news about DHRSX

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DHRSX gene: 
NM_145177.2  

Unigene Cluster for DHRSX:

Dehydrogenase/reductase (SDR family) X-linked
Hs.131452  [show with all ESTs]
Unigene Representative Sequence: NM_001171135
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000334651(uc004cqf.4) ENST00000412516 ENST00000464935 ENST00000444280
ENST00000441131 ENST00000478825 ENST00000430536
miRNA
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Additional mRNA sequence: 

AB018328.1 AJ293620.1 AK094243.1 AL137300.1 AY358849.1 BC009269.1 BC015030.1 BC019696.2 
BC032340.1 Y16947.1 

24/40 DOTS entries (see all 40):

DT.100777533  DT.414019  DT.416034  DT.95265963  DT.100773088  DT.120651111  DT.97823883  DT.121304529 
DT.120651081  DT.121304536  DT.100023950  DT.120651140  DT.120651149  DT.121304553  DT.40296624  DT.75191576 
DT.95265961  DT.99927503  DT.121304458  DT.70101062  DT.100001102  DT.121304556  DT.91723468  DT.95373173 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for DHRSX    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1:                    -     -     -     -               
SP2:                                                      
SP3:              -                                       
SP4:              -                                       


ECgene alternative splicing isoforms for DHRSX

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DHRSX expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TAGAACTGCT
DHRSX Expression
About this image


See DHRSX Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DHRSX

SOURCE GeneReport for Unigene cluster: Hs.131452

UniProtKB/Swiss-Prot: DHRSX_HUMAN, Q8N5I4
Tissue specificity: Widely expressed

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHRSX

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for DHRSX gene from 7/15 species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Dhrsx1 dehydrogenase/reductase (SDR family) X chromosome 63.27(n)
57.41(a)
  236082  NM_001033326.2  NP_001028498.2 
chicken
(Gallus gallus)
Aves DHRSX1 dehydrogenase/reductase (SDR family) X-linked 71.46(n)
71.23(a)
  428007  XM_001232713.2  XP_001232714.2 
lizard
(Anolis carolinensis)
Reptilia DHRSX6
Uncharacterized protein
63(a)
1 ↔ 1
3(113554604-113723537)
zebrafish
(Danio rerio)
Actinopterygii dhrsx1 dehydrogenase/reductase (SDR family) X-linked 60.79(n)
55.77(a)
  100318301  XM_002660507.2  XP_002660553.1 
fruit fly
(Drosophila melanogaster)
Insecta CG112001 Carbonyl reductase 51.02(n)
40.07(a)
  37301  NM_166388.2  NP_725952.1 
worm
(Caenorhabditis elegans)
Secernentea dhs-226
Protein DHS-22
28(a)
possible ortholog
V(14420052-14421450)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENV96
Protein proposed to be involved in vacuolar functi...
23(a)
1 → many
XV(795801-796793)


ENSEMBL Gene Tree for DHRSX (if available)
TreeFam Gene Tree for DHRSX (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for DHRSX gene
ENSG000002584662  DHRS122  WWOX2  RDH122  DHRS132  RDH142  RDH132  RDH112  
9 SIMAP similar genes for DHRSX using alignment to 5 protein entries:     DHRSX_HUMAN (see all proteins):
DHRS2    NT5C1B-RDH14    DHRS4    DHRS4L2    RDH11    HSD17B12
RDH13    RDH12    RDH14

DHRSX for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

3 SNPs in DHRSX are shown    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0553554
----see VAR_0553552 H R mis40--------
VAR_0161004
----see VAR_0161002 E K mis40--------
VAR_0553544
----see VAR_0553542 V L mis40--------

HapMap Linkage Disequilibrium report for DHRSX (2137547 - 2387547 bp, first 250kb of DHRSX)

Structural Variations
     Database of Genomic Variants (DGV) 10/54 variations for DHRSX (see all 54):    About this table     
Variant IDTypeSubtypePubMed ID
esv2739859CNV Deletion23290073
esv2739833CNV Deletion23290073
esv2739838CNV Deletion23290073
esv2739865CNV Deletion23290073
esv2739863CNV Deletion23290073
esv2666881CNV Deletion23128226
esv2658918CNV Deletion23128226
esv2660086CNV Deletion23128226
esv2356582CNV Deletion18987734
esv2739843CNV Deletion23290073

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for DHRSX:    About MalaCards
tuberculosis    gastric cancer


DHRSX for disorders           About GeneDecksing


Export disorders for DHRSX gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for DHRSX gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with DHRSX)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Differential divergence of three human pseudoautosomal genes and their mouse homologs: implications for sex chromosome evolution. (PubMed id 11731500)1, 2, 3, 9 Gianfrancesco F.... D'Urso M. (2001)
  2. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (2009)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
  5. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (2013)
  6. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
  7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
  8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
  9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
  10. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 207063 HGNC: 18399 Ensembl:ENSG00000169084 euGenes: HUgn207063 ECgene: DHRSX
H-InvDB: DHRSX

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for DHRSX Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for DHRSX gene:
Search GeneIP for patents involving DHRSX

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Proteins for DHRSX
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 inGenious Targeting Laboratory - Custom generated mouse model solutions for DHRSX
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Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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