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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DHRS9 Gene

protein-coding   GIFtS: 55
GCID: GC02P169921

Dehydrogenase/Reductase (SDR Family) Member 9

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dehydrogenase/Reductase (SDR Family) Member 91 2     Member 41
3-Alpha Hydroxysteroid Dehydrogenase1 2 3     Short Chain Dehydrogenase/Reductase Family 9C1
NADP-Dependent Retinol Dehydrogenase/Reductase1 2 3     3ALPHA-HSD2
Retinol Dehydrogenase Homolog1 2     RDH152
Short-Chain Dehydrogenase/Reductase RetSDR82 3     RETSDR82
Tracheobronchial Epithelial Cell-Specific Retinol Dehydrogenase2 3     SDR9C42
3-alpha-HSD2 3     Dehydrogenase/Reductase SDR Family Member 92
RDH-E22 3     Short Chain Dehydrogenase/Reductase Family 9C, Member 42
RDH-TBE2 3     EC 1.1.-.-3
RDHL2 3     EC 1.1.18
RDHTBE2 5     EC 1.1.1.1058

External Ids:    HGNC: 168881   Entrez Gene: 101702   Ensembl: ENSG000000737377   OMIM: 6121315   UniProtKB: Q9BPW93   

Export aliases for DHRS9 gene to outside databases

Previous GC identifers: GC02P170123 GC02P169746 GC02P169629 GC02P161819


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DHRS9 Gene: 
DHRS9 (dehydrogenase/reductase (SDR family) member 9) is a protein-coding gene. Diseases associated with DHRS9 include postpartum depression, and smith-lemli-opitz syndrome, and among its related super-pathways are retinol biosynthesis and Metabolism. GO annotations related to this gene include alcohol dehydrogenase (NAD) activity and nucleotide binding. An important paralog of this gene is SDR9C7.

UniProtKB/Swiss-Prot: DHRS9_HUMAN, Q9BPW9
Function: 3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to
dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of
retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH

Gene Wiki entry for DHRS9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DHRS9 gene promoter:
         Nkx3-1   ER-alpha   Nkx3-1 v1   IRF-1   Nkx5-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DHRS9 promoter sequence
   Search SABiosciences Chromatin IP Primers for DHRS9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHRS9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

DHRS9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHRS9 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P169921:  view genomic region     (about GC identifiers)

Start:
169,921,299 bp from pter      End:
169,952,677 bp from pter
Size:
31,379 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DHRS9_HUMAN, Q9BPW9 (See protein sequence)
Recommended Name: Dehydrogenase/reductase SDR family member 9 precursor  
Size: 319 amino acids; 35227 Da
Subunit: Homotetramer (By similarity)
Subcellular location: Microsome membrane. Endoplasmic reticulum membrane (Potential). Note=Associated with
microsomal membranes
Secondary accessions: D3DPC1 Q5RKX1 Q9NRA9 Q9NRB0
Alternative splicing: 3 isoforms:  Q9BPW9-1   Q9BPW9-2   Q9BPW9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DHRS9: NX_Q9BPW9

Explore proteomics data for DHRS9 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BPW9

  • 2 DME Specific Peptides for DHRS9 (Q9BPW9)
     VTLNMLP  TGCDSGFG 

    DHRS9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DHRS9 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001135742.1  NP_001135743.1  NP_005762.2  NP_954674.1  

    ENSEMBL proteins: 
     ENSP00000473337   ENSP00000350154   ENSP00000388564   ENSP00000391214   ENSP00000388066  
     ENSP00000407167   ENSP00000389241   ENSP00000316670   ENSP00000407747  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030176integral to endoplasmic reticulum membrane IDA11294878

    DHRS9 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SDRC2: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 2

    3 InterPro protein domains:
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q9BPW9

    ProtoNet protein and cluster: Q9BPW9

    1 Blocks protein domain: IPB002198 Short-chain dehydrogenase/reductase SDR

    UniProtKB/Swiss-Prot: DHRS9_HUMAN, Q9BPW9
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    DHRS9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DHRS9_HUMAN, Q9BPW9
    Function: 3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to
    dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of
    retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH
    Biophysicochemical properties: Kinetic parameters: KM=9 uM for NADH; KM=72 uM for NAD; KM=5 uM for
    allopregnanolone; KM=7.5 uM for 3-alpha-androstanediol; KM=24 uM for androsterone; KM=12 uM for
    dihydrotestosterone;

         Enzyme Numbers (IUBMB): EC 1.1.-.-1 EC 1.1.12 EC 1.1.1.1052

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004022alcohol dehydrogenase (NAD) activity IDA11304534
    GO:0004745retinol dehydrogenase activity IDA11304534
    GO:0016491oxidoreductase activity ----
    GO:0016854racemase and epimerase activity NAS11294878
    GO:0047035testosterone dehydrogenase (NAD+) activity IDA11294878
         
    DHRS9 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Dhrs9):
     no phenotypic analysis 

    DHRS9 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dhrs9tm1Drie for DHRS9

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DHRS9 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DHRS9

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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DHRS9 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1the visual cycle I (vertebrates)
    the visual cycle I (vertebrates)0.52
    retinol biosynthesis0.52
    2Metabolism
    Metabolic pathways0.40
    3Drug metabolism - cytochrome P450
    Retinol metabolism0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for DHRS9
        retinol biosynthesis
    the visual cycle I (vertebrates)



    2         Kegg Pathways  (Kegg details for DHRS9):
        Retinol metabolism
    Metabolic pathways


    DHRS9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DHRS9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for DHRS9 (ENSP000003166704) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    ALDH1A2ENSP000002497504STRING: ENSP00000249750
    CYP26A1ENSP000002243564STRING: ENSP00000224356
    DGAT1ENSP000003322584STRING: ENSP00000332258
    LRATENSP000003372244STRING: ENSP00000337224
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002138retinoic acid biosynthetic process ----
    GO:0008152metabolic process ----
    GO:0008209androgen metabolic process IDA11294878
    GO:0030855epithelial cell differentiation NAS11304534
    GO:0042448progesterone metabolic process IDA11294878

    DHRS9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DHRS9 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for DHRS9

    4 HMDB Compounds for DHRS9    About this table
    CompoundSynonyms CAS #PubMed Ids
    Androsterone(3R,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one (see all 28)53-41-81576998
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--

    10/47 Novoseek inferred chemical compound relationships for DHRS9 gene (see all 47)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    3alpha-hydroxysteroid 99.3 195 7626489 (7), 1639345 (4), 1719938 (4), 2317205 (3) (see all 99)
    5alpha-androstane-3alpha,17beta-diol 93.9 13 16179381 (2), 9415401 (1), 11294878 (1), 18923939 (1) (see all 12)
    chlordecone 86 4 8274401 (2), 7626489 (1), 9310340 (1)
    5alpha-dihydroprogesterone 85.9 9 10557352 (2), 12416991 (1), 16611167 (1), 16344854 (1) (see all 5)
    androstanedione 85.7 1 11348472 (1)
    dihydrotestosterone 85.1 31 16179381 (2), 9415401 (1), 8920937 (1), 10760475 (1) (see all 20)
    9-cis-retinol 80.8 2 12646198 (1), 9931293 (1)
    17beta-hydroxysteroid 80.1 13 2335445 (1), 11348472 (1), 11720889 (1), 18723074 (1) (see all 12)
    5,16-androstadien-3beta-ol 78.7 1 11457660 (1)
    3beta-hydroxysteroid 76.5 14 11348472 (2), 1639345 (1), 11457660 (1), 2153675 (1) (see all 11)

    Search CenterWatch for drugs/clinical trials and news about DHRS9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DHRS9 gene (4 alternative transcripts): 
    NM_001142270.1  NM_001142271.1  NM_005771.4  NM_199204.1  

    Unigene Cluster for DHRS9:

    Dehydrogenase/reductase (SDR family) member 9
    Hs.179608  [show with all ESTs]
    Unigene Representative Sequence: NM_005771
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000602501 ENST00000357546(uc002uer.1 uc002ueq.3 uc010zdc.2)
    ENST00000428522 ENST00000450153 ENST00000421653 ENST00000436483(uc010zdd.2)
    ENST00000432060 ENST00000327239(uc002uep.3) ENST00000412271(uc010zde.2)

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    Inhib. RNA
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    Additional mRNA sequence: 

    AF067174.1 AF240697.1 AF240698.1 AF295380.1 AF343729.1 AF529286.1 AF529287.1 AF529288.1 
    AK296625.1 AK313220.1 AY017349.1 AY359046.1 BC040380.1 BC051797.1 BC058883.1 

    7 DOTS entries:

    DT.95272980  DT.310148  DT.100775125  DT.95272981  DT.120947382  DT.95272979  DT.40199568 

    24/87 AceView cDNA sequences (see all 87):

    BC058883 CA307349 BU634525 BQ877944 AF295380 BC040380 AF529287 AW188672 
    AF240698 AF529286 NM_199204 BM826009 AW593685 AA481041 BQ689901 AF343729 
    AA609992 AI041126 NM_005771 AA608938 AF529288 BU157695 BM921803 CA435602 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for DHRS9 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b
    SP1:                                                              -     -                                                                     
    SP2:                                -     -     -     -     -     -     -                                                                     
    SP3:                                      -           -     -     -     -                                                                     
    SP4:                                                                                                                                          
    SP5:                                                                                                                          -               


    ECgene alternative splicing isoforms for DHRS9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DHRS9 expression in normal human tissues (normalized intensities)      DHRS9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DHRS9 Expression
    About this image


    DHRS9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Lung (Respiratory System)    fully expand to see all 4 entries
             Human Pulmonary Artery Smooth Muscle Cells (HPASMC)   
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Peripheral blood-derived endothelial progenitor cells
             Human Cardiac Microvascular Endothelial Cells (HCMEC)   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Umbilical cord blood-derived hematopoietic stem cells
             Fetal Liver CD34+ Cells   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Human Cardiac Myocytes-adult (HCM-a)   
     
     Epithelium (Uncategorized)    fully expand to see all 2 entries
             Human Tracheal Epithelial Cells (HTEpiC)   

    See DHRS9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DHRS9

    SOURCE GeneReport for Unigene cluster: Hs.179608

    UniProtKB/Swiss-Prot: DHRS9_HUMAN, Q9BPW9
    Tissue specificity: Highly expressed in trachea and epidermis. Detected at lower levels in spinal cord, bone
    marrow, brain, tongue, esophagus, heart, colon, testis, placenta, lung, skeletal muscle and lymph node

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DHRS9 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dhrs91 , 5 dehydrogenase/reductase (SDR family) member 91, 5 86(n)1
    85.89(a)1
      2 (40.59 cM)5
    2414521  NM_175512.21  NP_780721.11 
     693804455 
    chicken
    (Gallus gallus)
    Aves RDH51 retinol dehydrogenase 5 (11-cis/9-cis) 66.13(n)
    61.66(a)
      424169  XM_422015.2  XP_422015.2 
    lizard
    (Anolis carolinensis)
    Reptilia DHRS96
    dehydrogenase/reductase (SDR family) member 9
    56(a)
    1 ↔ 1
    GL343362.1(20413-40390)
    African clawed frog
    (Xenopus laevis)
    Amphibia rdhl-prov2 NADP-dependent retinol dehydrogenase/reductase 75.22(n)    BC056045.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F55E10.66
    dhs-206
    (see all 4)
    Protein DHS-20
    (see all 4)
    32(a)
    31(a)
    (see all 4)
    1 ↔ many
    1 ↔ many
    (see all 4)
    X(8344700-8346359)
    V(11602312-11604563)


    ENSEMBL Gene Tree for DHRS9 (if available)
    TreeFam Gene Tree for DHRS9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DHRS9 gene
    SDR9C72  HSD11B22  HSD17B62  HSD17B22  BDH12  RDH162  RDH82  DHRS7B2  
    DHRS72  HSD17B12  KDSR2  DHRS7C2  RDH52  
    8 SIMAP similar genes for DHRS9 using alignment to 4 protein entries:     DHRS9_HUMAN (see all proteins):
    RDHL    HSD17B6    RDH5    RDH16    SDR9C7    BDH1
    HSD17B2    HSD11B2

    DHRS9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/770 SNPs in DHRS9 are shown (see all 770)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1468647871,2
    C--161832546(+) TGCCCC/GCCTCT 1 -- us2k10--------
    rs1890837731,2
    --169919301(+) TCTACA/TTCACT 1 -- us2k10--------
    rs134033301,2
    C,F,A--169919329(+) GCCAAT/CCGACT 1 -- us2k1 tfbs33Minor allele frequency- C:0.06CSA WA 122
    rs1446843481,2
    --169919330(+) CCAATC/TGACTT 1 -- us2k10--------
    rs1485253821,2
    C--169919346(+) GGGTAG/TTTATA 1 -- us2k10--------
    rs787158051,2
    --169919351(+) GTTATA/CATGAT 1 -- us2k10--------
    rs134033391,2
    C,F--169919377(+) GGAAGT/CTTCAT 1 -- us2k17Minor allele frequency- C:0.03NA CSA WA EA 384
    rs134152921,2
    C,F--169919470(+) ccatgA/Gcaaaa 1 -- us2k13Minor allele frequency- G:0.06CSA WA 122
    rs134034271,2
    C,F,A,H--169919477(+) aaaaaT/Acaaat 1 -- us2k17Minor allele frequency- A:0.01NS EA CSA WA 536
    rs1465861461,2
    C--169919573(+) TAAACC/TTGTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DHRS9 (169921299 - 169952677 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DHRS9:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv528457CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612131    OMIM disorders: --

    16 diseases for DHRS9:    About MalaCards
    postpartum depression    smith-lemli-opitz syndrome    open-angle glaucoma    primary open angle glaucoma
    prostate cancer, progression of    glaucoma    duodenitis    prostate cancer
    liver disease    prostatitis    alcoholism    neuroblastoma
    adenoma    tuberculosis    hepatitis    neuronitis


    DHRS9 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for DHRS9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 25 4 18923939 (1), 12539226 (1), 18320593 (1)
    colon carcinoma 6.61 2 15190067 (2)
    adenoma 0.731 4 15190067 (2), 9213242 (1), 8550804 (1)
    epilepsy 0 2 12742591 (1), 11238528 (1)
    tumors 0 1 10476344 (1)
    carcinoma 0 3 15190067 (2), 8550804 (1)


    Export disorders for DHRS9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DHRS9 gene, integrated from 9 sources (see all 155):
    (articles sorted by number of sources associating them with DHRS9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a novel type of human microsomal 3alpha -hydroxysteroid dehydrogenase: unique tissue distribution and catalytic properties. (PubMed id 11294878)1, 2, 3, 9 Chetyrkin S.V....Kedishvili N.Y. (2001)
    2. Characterization of a novel airway epithelial cell-specific short chain alcohol dehydrogenase/reductase gene whose expression is up- regulated by retinoids and is involved in the metabolism of retinol. (PubMed id 11304534)1, 2, 3 Soref C.M.... Wu R. (2001)
    3. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Expression pattern and biochemical characteristics of a major epidermal retinol dehydrogenase. (PubMed id 12618084)1, 2 Markova N.G.... Simon M. (2003)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. Short-chain dehydrogenases/reductases in retina. (PubMed id 10800688)1, 2 Haeseleer F. and Palczewski K. (2000)
    8. The tumor suppressor adenomatous polyposis coli and caudal related homeodomain protein regulate expression of retinol dehydrogenase L. (PubMed id 15190067)1, 9 Jette C....Jones D.A. (2004)
    9. Epstein-Barr virus lytic infection induces retinoic acid-responsive genes through induction of a retinol-metabolizing enzyme, DHRS9. (PubMed id 17244623)1 Jones R.J....Kenney S.C. (2007)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10170 HGNC: 16888 AceView: DHRS9 Ensembl:ENSG00000073737 euGenes: HUgn10170
    ECgene: DHRS9 Kegg: 10170 H-InvDB: DHRS9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DHRS9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DHRS9 gene:
    Search GeneIP for patents involving DHRS9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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