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DHRS9 Gene

protein-coding   GIFtS: 54
GCID: GC02P169921

Dehydrogenase/Reductase (SDR Family) Member 9

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dehydrogenase/Reductase (SDR Family) Member 91 2     Member 41
3-Alpha Hydroxysteroid Dehydrogenase1 2 3     Short Chain Dehydrogenase/Reductase Family 9C1
NADP-Dependent Retinol Dehydrogenase/Reductase1 2 3     3ALPHA-HSD2
Retinol Dehydrogenase Homolog1 2     RDH152
Short-Chain Dehydrogenase/Reductase RetSDR82 3     RETSDR82
Tracheobronchial Epithelial Cell-Specific Retinol Dehydrogenase2 3     SDR9C42
3-alpha-HSD2 3     Dehydrogenase/Reductase SDR Family Member 92
RDH-E22 3     Short Chain Dehydrogenase/Reductase Family 9C, Member 42
RDH-TBE2 3     EC 1.1.-.-3
RDHL2 3     EC 1.1.18
RDHTBE2 5     EC 1.1.1.1058

External Ids:    HGNC: 168881   Entrez Gene: 101702   Ensembl: ENSG000000737377   OMIM: 6121315   UniProtKB: Q9BPW93   

Export aliases for DHRS9 gene to outside databases

Previous GC identifers: GC02P170123 GC02P169746 GC02P169629 GC02P161819


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DHRS9 Gene:
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been
identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This
protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert
3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in
the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, Jan 2014)

GeneCards Summary for DHRS9 Gene:
DHRS9 (dehydrogenase/reductase (SDR family) member 9) is a protein-coding gene. GO annotations related to this gene include testosterone dehydrogenase (NAD+) activity and retinol dehydrogenase activity. An important paralog of this gene is SDR9C7.

UniProtKB/Swiss-Prot: DHRS9_HUMAN, Q9BPW9
Function: 3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to
dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of
retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH

Gene Wiki entry for DHRS9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DHRS9 gene promoter:
         Nkx3-1   ER-alpha   Nkx3-1 v1   IRF-1   Nkx5-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DHRS9 promoter sequence
   Search Chromatin IP Primers for DHRS9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DHRS9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

DHRS9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHRS9 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P169921:  view genomic region     (about GC identifiers)

Start:
169,921,299 bp from pter      End:
169,952,677 bp from pter
Size:
31,379 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DHRS9_HUMAN, Q9BPW9 (See protein sequence)
Recommended Name: Dehydrogenase/reductase SDR family member 9 precursor  
Size: 319 amino acids; 35227 Da
Subunit: Homotetramer (By similarity)
Secondary accessions: D3DPC1 Q5RKX1 Q9NRA9 Q9NRB0
Alternative splicing: 3 isoforms:  Q9BPW9-1   Q9BPW9-2   Q9BPW9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DHRS9: NX_Q9BPW9

Explore proteomics data for DHRS9 at MOPED

2 DME Specific Peptides for DHRS9 (Q9BPW9)
 VTLNMLP  TGCDSGFG 


See DHRS9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (5 alternative transcripts): 
NP_001135742.1  NP_001135743.1  NP_001276692.1  NP_954674.1  NP_005762.2  

ENSEMBL proteins: 
 ENSP00000473337   ENSP00000350154   ENSP00000388564   ENSP00000391214   ENSP00000388066  
 ENSP00000407167   ENSP00000389241   ENSP00000316670   ENSP00000407747  
Reactome Protein details: Q9BPW9

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
SDRC2: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 2

3 InterPro protein domains:
 IPR002347 Glc/ribitol_DH
 IPR002198 DH_sc/Rdtase_SDR
 IPR016040 NAD(P)-bd_dom

Graphical View of Domain Structure for InterPro Entry Q9BPW9

ProtoNet protein and cluster: Q9BPW9

1 Blocks protein domain: IPB002198 Short-chain dehydrogenase/reductase SDR

UniProtKB/Swiss-Prot: DHRS9_HUMAN, Q9BPW9
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


Find genes that share domains with DHRS9           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: DHRS9_HUMAN, Q9BPW9
Function: 3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to
dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of
retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH
Biophysicochemical properties: Kinetic parameters: KM=9 uM for NADH; KM=72 uM for NAD; KM=5 uM for
allopregnanolone; KM=7.5 uM for 3-alpha-androstanediol; KM=24 uM for androsterone; KM=12 uM for
dihydrotestosterone;

     Enzyme Numbers (IUBMB): EC 1.1.-.-1 EC 1.1.12 EC 1.1.1.1052

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004022alcohol dehydrogenase (NAD) activity IDA11304534
GO:0004745retinol dehydrogenase activity IDA11304534
GO:0016491oxidoreductase activity ----
GO:0016854racemase and epimerase activity NAS11294878
GO:0047035testosterone dehydrogenase (NAD+) activity IDA11294878
     
Find genes that share ontologies with DHRS9           About GenesLikeMe


Phenotypes:
     1 MGI mutant phenotype (inferred from 1 allele(MGI details for Dhrs9):
 no phenotypic analysis 

Find genes that share phenotypes with DHRS9           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Dhrs9tm1Drie for DHRS9

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
DHRS9_HUMAN, Q9BPW9: Microsome membrane. Endoplasmic reticulum membrane (Potential). Note=Associated with
microsomal membranes
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
endoplasmic reticulum5
cytosol2
extracellular2
nucleus2
plasma membrane2
mitochondrion1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0030176integral component of endoplasmic reticulum membrane IDA11294878

Find genes that share ontologies with DHRS9           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for DHRS9 About   (see all 7)  
See pathways by source

SuperPathContained pathways About
1the visual cycle I (vertebrates)
the visual cycle I (vertebrates)0.52
The canonical retinoid cycle in rods (twilight vision)0.44
retinol biosynthesis0.52
2Diseases associated with visual transduction
Visual phototransduction0.44
Diseases associated with visual transduction0.43
3Signaling by GPCR
Signal Transduction0.58
4Metabolism
Metabolic pathways0.38
5Chemical carcinogenesis
Retinol metabolism0.35


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Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


3 BioSystems Pathways for DHRS9
    cardenolide biosynthesis
the visual cycle I (vertebrates)
retinol biosynthesis


1 Reactome Pathway for DHRS9
    The canonical retinoid cycle in rods (twilight vision)


2 Kegg Pathways  (Kegg details for DHRS9):
    Retinol metabolism
Metabolic pathways

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DHRS9
Interactions:

    GeneGlobe Interaction Network for DHRS9

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

Selected Interacting proteins for DHRS9 (ENSP000003166704) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
InteractantInteraction Details
GeneCardExternal ID(s)
ALDH1A1ENSP000002977854STRING: ENSP00000297785
ALDH1A2ENSP000002497504STRING: ENSP00000249750
BCMO1ENSP000002581684STRING: ENSP00000258168
CYP26A1ENSP000002243564STRING: ENSP00000224356
DGAT1ENSP000003322584STRING: ENSP00000332258
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Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002138retinoic acid biosynthetic process ----
GO:0008152metabolic process ----
GO:0008209androgen metabolic process IDA11294878
GO:0030855epithelial cell differentiation NAS11304534
GO:0042448progesterone metabolic process IDA11294878

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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  Browse compounds at ApexBio 

Browse Tocris compounds for DHRS9

4 HMDB Compounds for DHRS9    About this table
CompoundSynonyms CAS #PubMed Ids
Androsterone(3R,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one (see all 28)53-41-81576998
NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--

Selected Novoseek inferred chemical compound relationships for DHRS9 gene (see all 47)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
3alpha-hydroxysteroid 99.3 195 7626489 (7), 1639345 (4), 1719938 (4), 2317205 (3) (see all 99)
5alpha-androstane-3alpha,17beta-diol 93.9 13 16179381 (2), 9415401 (1), 11294878 (1), 18923939 (1) (see all 12)
chlordecone 86 4 8274401 (2), 7626489 (1), 9310340 (1)
5alpha-dihydroprogesterone 85.9 9 10557352 (2), 12416991 (1), 16611167 (1), 16344854 (1) (see all 5)
androstanedione 85.7 1 11348472 (1)
dihydrotestosterone 85.1 31 16179381 (2), 9415401 (1), 8920937 (1), 10760475 (1) (see all 20)
9-cis-retinol 80.8 2 12646198 (1), 9931293 (1)
17beta-hydroxysteroid 80.1 13 2335445 (1), 11348472 (1), 11720889 (1), 18723074 (1) (see all 12)
5,16-androstadien-3beta-ol 78.7 1 11457660 (1)
3beta-hydroxysteroid 76.5 14 11348472 (2), 1639345 (1), 11457660 (1), 2153675 (1) (see all 11)



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for DHRS9 gene (5 alternative transcripts): 
NM_001142270.1  NM_001142271.1  NM_001289763.1  NM_199204.1  NM_005771.4  

Unigene Cluster for DHRS9:

Dehydrogenase/reductase (SDR family) member 9
Hs.179608  [show with all ESTs]
Unigene Representative Sequence: NM_005771
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000602501 ENST00000357546(uc002uer.1 uc002ueq.3 uc010zdc.2)
ENST00000428522 ENST00000450153 ENST00000421653 ENST00000436483(uc010zdd.2)
ENST00000432060 ENST00000327239(uc002uep.3) ENST00000412271(uc010zde.2)

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  QuantiFast Probe-based Assays in human, mouse, rat DHRS9

Additional mRNA sequence: 

AF067174.1 AF240697.1 AF240698.1 AF295380.1 AF343729.1 AF529286.1 AF529287.1 AF529288.1 
AK296625.1 AK313220.1 AY017349.1 AY359046.1 BC040380.1 BC051797.1 BC058883.1 

7 DOTS entries:

DT.95272980  DT.310148  DT.100775125  DT.95272981  DT.120947382  DT.95272979  DT.40199568 

Selected AceView cDNA sequences (see all 87):

NM_199204 AA608938 AW593685 AF343729 AF240698 BU157695 BC058883 AF529286 
AW188672 NM_005771 BQ877944 AA609992 BC040380 AA481041 BM826009 BQ689901 
AI041126 AF295380 CA435602 AF529287 AF529288 CA307349 BM921803 BU634525 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for DHRS9 (see all 10)    About this scheme

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b
SP1:                                                              -     -                                                                     
SP2:                                -     -     -     -     -     -     -                                                                     
SP3:                                      -           -     -     -     -                                                                     
SP4:                                                                                                                                          
SP5:                                                                                                                          -               


ECgene alternative splicing isoforms for DHRS9

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DHRS9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
DHRS9 Expression
About this image


DHRS9 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Blood (Hematopoietic System)    fully expand to see all 2 entries
         Hematopoietic Stem Cells Hematopoietic Bone Marrow
 
 Ovary (Reproductive System)
         Mature Granulosa Cells Antral Follicle
 
 Colon (Gastrointestinal Tract)
DHRS9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

DHRS9 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.179608

UniProtKB/Swiss-Prot: DHRS9_HUMAN, Q9BPW9
Tissue specificity: Highly expressed in trachea and epidermis. Detected at lower levels in spinal cord, bone
marrow, brain, tongue, esophagus, heart, colon, testis, placenta, lung, skeletal muscle and lymph node

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for DHRS9 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Dhrs91 , 5 dehydrogenase/reductase (SDR family) member 91, 5 86(n)1
85.89(a)1
  2 (40.59 cM)5
2414521  NM_175512.21  NP_780721.11 
 693804455 
chicken
(Gallus gallus)
Aves RDH51 retinol dehydrogenase 5 (11-cis/9-cis) 66.13(n)
61.66(a)
  424169  XM_004942760.1  XP_004942817.1 
lizard
(Anolis carolinensis)
Reptilia DHRS96
dehydrogenase/reductase (SDR family) member 9
56(a)
1 ↔ 1
GL343362.1(20413-40390)
African clawed frog
(Xenopus laevis)
Amphibia rdhl-prov2 NADP-dependent retinol dehydrogenase/reductase 75.22(n)    BC056045.1 
zebrafish
(Danio rerio)
Actinopterygii rdh16
retinol dehydrogenase 1
44(a)
many ↔ many
9(49726841-49748125) ENSDARG00000017882


ENSEMBL Gene Tree for DHRS9 (if available)
TreeFam Gene Tree for DHRS9 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for DHRS9 gene
SDR9C72  HSD11B22  HSD17B62  HSD17B22  BDH12  RDH162  RDH82  DHRS7B2  
DHRS72  HSD17B12  KDSR2  DHRS7C2  RDH52  
8 SIMAP similar genes for DHRS9 using alignment to 4 protein entries:     DHRS9_HUMAN (see all proteins):
RDHL    HSD17B6    RDH5    RDH16    SDR9C7    BDH1
HSD17B2    HSD11B2

Find genes that share paralogs with DHRS9           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for DHRS9 (see all 770)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1468647871,2
C--161832546(+) TGCCCC/GCCTCT 1 -- us2k10--------
rs1890837731,2
--169919301(+) TCTACA/TTCACT 1 -- us2k10--------
rs134033301,2
C,F,A--169919329(+) GCCAAT/CCGACT 1 -- us2k1 tfbs33Minor allele frequency- C:0.06CSA WA 122
rs1446843481,2
--169919330(+) CCAATC/TGACTT 1 -- us2k10--------
rs1485253821,2
C--169919346(+) GGGTAG/TTTATA 1 -- us2k10--------
rs787158051,2
--169919351(+) GTTATA/CATGAT 1 -- us2k10--------
rs134033391,2
C,F--169919377(+) GGAAGT/CTTCAT 1 -- us2k17Minor allele frequency- C:0.03NA CSA WA EA 384
rs134152921,2
C,F--169919470(+) ccatgA/Gcaaaa 1 -- us2k13Minor allele frequency- G:0.06CSA WA 122
rs134034271,2
C,F,A,H--169919477(+) aaaaaT/Acaaat 1 -- us2k17Minor allele frequency- A:0.01NS EA CSA WA 536
rs1465861461,2
C--169919573(+) TAAACC/TTGTGT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for DHRS9 (169921299 - 169952677 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for DHRS9:    About this table    
Variant IDTypeSubtypePubMed ID
nsv528457CNV Gain19592680

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing DHRS9
DNA2.0 Custom Variant and Variant Library Synthesis for DHRS9

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 612131    OMIM disorders: --


Find genes that share disorders with DHRS9           About GenesLikeMe

6 Novoseek inferred disease relationships for DHRS9 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer 25 4 18923939 (1), 12539226 (1), 18320593 (1)
colon carcinoma 6.61 2 15190067 (2)
adenoma 0.731 4 15190067 (2), 9213242 (1), 8550804 (1)
epilepsy 0 2 12742591 (1), 11238528 (1)
tumors 0 1 10476344 (1)
carcinoma 0 3 15190067 (2), 8550804 (1)


Export disorders for DHRS9 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for DHRS9 gene, integrated from 10 sources (see all 156):
(articles sorted by number of sources associating them with DHRS9)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Characterization of a novel type of human microsomal 3alpha- hydroxysteroid dehydrogenase. Unique tissue distribution and catalytic properties. (PubMed id 11294878)1, 2, 3, 9 Chetyrkin S.V.... Kedishvili N.Y. (J. Biol. Chem. 2001)
  2. Characterization of a novel airway epithelial cell-specific short chain alcohol dehydrogenase/reductase gene whose expression is up- regulated by retinoids and is involved in the metabolism of retinol. (PubMed id 11304534)1, 2, 3 Soref C.M.... Wu R. (J. Biol. Chem. 2001)
  3. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (Chem. Biol. Interact. 2009)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Expression pattern and biochemical characteristics of a major epidermal retinol dehydrogenase. (PubMed id 12618084)1, 2 Markova N.G.... Simon M. (Mol. Genet. Metab. 2003)
  6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
  7. Short-chain dehydrogenases/reductases in retina. (PubMed id 10800688)1, 2 Haeseleer F. and Palczewski K. (Methods Enzymol. 2000)
  8. The tumor suppressor adenomatous polyposis coli and caudal related homeodomain protein regulate expression of retinol dehydrogenase L. (PubMed id 15190067)1, 9 Jette C....Jones D.A. (J. Biol. Chem. 2004)
  9. Epstein-Barr virus lytic infection induces retinoic acid-responsive genes through induction of a retinol-metabolizing enzyme, DHRS9. (PubMed id 17244623)1 Jones R.J....Kenney S.C. (J. Biol. Chem. 2007)
  10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10170 HGNC: 16888 AceView: DHRS9 Ensembl:ENSG00000073737 euGenes: HUgn10170
ECgene: DHRS9 Kegg: 10170 H-InvDB: DHRS9

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for DHRS9 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for DHRS9 gene:
Search GeneIP for patents involving DHRS9

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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