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Aliases for DHRS7C Gene

Aliases for DHRS7C Gene

  • Dehydrogenase/Reductase (SDR Family) Member 7C 2 3
  • Short-Chain Dehydrogenase/Reductase Family 32C Member 2 3 4
  • SDR32C2 3 4
  • Short Chain Dehydrogenase/Reductase Family 32C, Member 2 3
  • Short Chain Dehydrogenase/Reductase Family 32C 2
  • Dehydrogenase/Reductase SDR Family Member 7C 3
  • EC 1.1.-.- 4
  • Member 2 2

External Ids for DHRS7C Gene

Previous GeneCards Identifiers for DHRS7C Gene

  • GC17M009616

Summaries for DHRS7C Gene

GeneCards Summary for DHRS7C Gene

DHRS7C (Dehydrogenase/Reductase (SDR Family) Member 7C) is a Protein Coding gene. GO annotations related to this gene include retinol dehydrogenase activity. An important paralog of this gene is HSD11B2.

UniProtKB/Swiss-Prot for DHRS7C Gene

  • Putative oxidoreductase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS7C Gene

Genomics for DHRS7C Gene

Regulatory Elements for DHRS7C Gene

Genomic Location for DHRS7C Gene

9,771,434 bp from pter
9,791,577 bp from pter
20,144 bases
Minus strand

Genomic View for DHRS7C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHRS7C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS7C Gene

Proteins for DHRS7C Gene

  • Protein details for DHRS7C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dehydrogenase/reductase SDR family member 7C
    Protein Accession:
    Secondary Accessions:
    • B7ZW74
    • B9EJH3

    Protein attributes for DHRS7C Gene

    312 amino acids
    Molecular mass:
    34878 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI47025.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI47026.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DHRS7C Gene


neXtProt entry for DHRS7C Gene

Proteomics data for DHRS7C Gene at MOPED

Post-translational modifications for DHRS7C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHRS7C Gene

No data available for DME Specific Peptides for DHRS7C Gene

Domains for DHRS7C Gene

Gene Families for DHRS7C Gene

Protein Domains for DHRS7C Gene

Suggested Antigen Peptide Sequences for DHRS7C Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS7C: view

Function for DHRS7C Gene

Molecular function for DHRS7C Gene

UniProtKB/Swiss-Prot Function:
Putative oxidoreductase.

Enzyme Numbers (IUBMB) for DHRS7C Gene

Gene Ontology (GO) - Molecular Function for DHRS7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004745 retinol dehydrogenase activity IEA --
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with DHRS7C: view

Phenotypes for DHRS7C Gene

GenomeRNAi human phenotypes for DHRS7C:
genes like me logo Genes that share phenotypes with DHRS7C: view

Animal Model Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DHRS7C Gene

Localization for DHRS7C Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHRS7C Gene


Subcellular locations from

Jensen Localization Image for DHRS7C Gene COMPARTMENTS Subcellular localization image for DHRS7C gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 2
plasma membrane 2
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DHRS7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0014801 longitudinal sarcoplasmic reticulum IEA --
GO:0033017 sarcoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with DHRS7C: view

Pathways for DHRS7C Gene

SuperPathways for DHRS7C Gene

No Data Available

Interacting Proteins for DHRS7C Gene

Gene Ontology (GO) - Biological Process for DHRS7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DHRS7C: view

No data available for Pathways by source for DHRS7C Gene

Transcripts for DHRS7C Gene

mRNA/cDNA for DHRS7C Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DHRS7C Gene

Dehydrogenase/reductase (SDR family) member 7C:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DHRS7C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS7C Gene

No ASD Table

Relevant External Links for DHRS7C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHRS7C Gene

mRNA expression in normal human tissues for DHRS7C Gene

mRNA differential expression in normal tissues according to GTEx for DHRS7C Gene

This gene is overexpressed in Heart - Atrial Appendage (23.2), Muscle - Skeletal (18.4), and Heart - Left Ventricle (9.6).

Protein differential expression in normal tissues for DHRS7C Gene

This gene is overexpressed in Heart (37.6) and Esophagus (26.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DHRS7C Gene

SOURCE GeneReport for Unigene cluster for DHRS7C Gene Hs.61684

genes like me logo Genes that share expressions with DHRS7C: view

Expression partners for DHRS7C Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DHRS7C Gene

Orthologs for DHRS7C Gene

This gene was present in the common ancestor of animals.

Orthologs for DHRS7C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DHRS7C 35
  • 88.8 (n)
  • 93.05 (a)
  • 94 (a)
(Canis familiaris)
Mammalia DHRS7C 35
  • 89.92 (n)
  • 95.5 (a)
  • 95 (a)
(Mus musculus)
Mammalia Dhrs7c 35
  • 88.09 (n)
  • 91.41 (a)
Dhrs7c 16
Dhrs7c 36
  • 91 (a)
(Pan troglodytes)
Mammalia DHRS7C 35
  • 99.46 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Dhrs7c 35
  • 87.29 (n)
  • 90.38 (a)
(Monodelphis domestica)
Mammalia DHRS7C 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia DHRS7C 36
  • 65 (a)
(Gallus gallus)
Aves DHRS7C 35
  • 73.45 (n)
  • 78.28 (a)
  • 77 (a)
(Anolis carolinensis)
Reptilia DHRS7C 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dhrs7c 35
  • 70.92 (n)
  • 78.97 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18984 35
(Danio rerio)
Actinopterygii dhrs7cb 35
  • 64.19 (n)
  • 59.01 (a)
dhrs7ca 36
  • 47 (a)
dhrs7cb 36
  • 54 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8653 35
fruit fly
(Drosophila melanogaster)
Insecta CG7601 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea C33E10.10 36
  • 24 (a)
dhs-30 36
  • 30 (a)
T25G12.13 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
Species with no ortholog for DHRS7C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHRS7C Gene

Gene Tree for DHRS7C (if available)
Gene Tree for DHRS7C (if available)

Paralogs for DHRS7C Gene

(1) SIMAP similar genes for DHRS7C Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DHRS7C: view

Variants for DHRS7C Gene

Sequence variations from dbSNP and Humsavar for DHRS7C Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs4791865 -- 9,773,969(+) CTGCC(C/T)GTCTT intron-variant
rs10459903 -- 9,787,339(+) ACAGA(C/G)AGCTA intron-variant
rs10852916 -- 9,790,219(+) ACTCA(A/G)TGGAC intron-variant
rs11078818 -- 9,789,731(+) TATTT(A/G)GAGAG intron-variant
rs11652420 -- 9,786,944(+) TGATG(A/G)GCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHRS7C Gene

Variant ID Type Subtype PubMed ID
nsv833358 CNV Gain 17160897
nsv510697 CNV Loss 20534489
nsv833360 CNV Loss 17160897
dgv176n21 CNV Loss 19592680
nsv528877 CNV Loss 19592680
nsv1976 CNV Loss 18451855
nsv833361 CNV Gain 17160897

Relevant External Links for DHRS7C Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHRS7C Gene

Disorders for DHRS7C Gene

No disorders were found for DHRS7C Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for DHRS7C Gene

Publications for DHRS7C Gene

  1. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3 4
  2. DHRS7c, a novel cardiomyocyte-expressed gene that is down-regulated by adrenergic stimulation and in heart failure. (PMID: 22143674) Lu B. … SilljAc H.H. (Eur. J. Heart Fail. 2012) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for DHRS7C Gene

Sources for DHRS7C Gene

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