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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DHRS7C Gene

protein-coding GIFtS: 40
GCID: GC17M009616

dehydrogenase/reductase (SDR family) member 7C

Explore 3 diseases affiliated with
DHRS7C via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Dehydrogenase/Reductase (SDR Family) Member 7C¹ ²
SDR32C2¹ ²
Dehydrogenase/Reductase SDR Family Member 7C²
Short Chain Dehydrogenase/Reductase Family 32C, Member 2²
EC 1.1.-.-³

External Ids:	HGNC: 32423¹	Entrez Gene: 201140²	Ensembl: ENSG00000184544⁷	UniProtKB: A6NNS2³

Export aliases for DHRS7C gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: DRS7C_HUMAN, A6NNS2

Function: Putative oxidoreductase (Potential)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010718.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DHRS7C gene promoter:
c-Fos RFX1 AP-1 AML1a Ik-3 YY1 E47 C/EBPalpha S8 c-Jun
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for DHRS7C

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHRS7C

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.1

DHRS7C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHRS7C gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M009616: view genomic region (about GC identifiers)

Start:	9,674,751 bp from pter	End:	9,694,614 bp from pter
Size:	19,864 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DRS7C_HUMAN, A6NNS2 (See protein sequence)

Recommended Name: Dehydrogenase/reductase SDR family member 7C precursor

Size: 312 amino acids; 34878 Da

Subcellular location: Secreted (Potential)

Secondary accessions: B7ZW74

Explore the universe of human proteins at neXtProt for DHRS7C: NX_A6NNS2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_A6NNS2

DHRS7C Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001099041.1 NP_001207422.1

ENSEMBL proteins:

ENSP00000461902 ENSP00000459579 ENSP00000327975

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Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0014801	longitudinal sarcoplasmic reticulum	IEA	--
GO:0033017	sarcoplasmic reticulum membrane	IEA	--

DHRS7C for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DHRS7C for domains About GeneDecksing

4 InterPro domains/families:

IPR020904 Sc_DH/Rdtase_CS

IPR016040 NAD(P)-bd_dom

IPR002347 Glc/ribitol_DH

IPR002198 DH_sc/Rdtase_SDR

Graphical View of Domain Structure for InterPro Entry A6NNS2

ProtoNet protein and cluster: A6NNS2

UniProtKB/Swiss-Prot: DRS7C_HUMAN, A6NNS2

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DRS7C_HUMAN, A6NNS2

Function: Putative oxidoreductase (Potential)

Enzyme Number (IUBMB): EC 1.1.-.-¹

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Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004745	retinol dehydrogenase activity	IEA	--
GO:0016491	oxidoreductase activity	--	--

DHRS7C for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for DHRS7C:

Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DHRS7C

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IEA	--

DHRS7C for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DHRS7C
Search CenterWatch for drugs/clinical trials and news about DHRS7C / DRS7C

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for DHRS7C gene (2 alternative transcripts):

NM_001105571.2 NM_001220493.1

Unigene Cluster for DHRS7C:

Dehydrogenase/reductase (SDR family) member 7C

Hs.61684 [show with all ESTs]

Unigene Representative Sequence: NM_001220493

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000571771 ENST00000571134(uc010cof.3) ENST00000330255(uc010vvb.2)

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Additional cDNA sequence:

BC147024.1 BC147025.1 BC171909.1

2 DOTS entries:

DT.408581 DT.75102047

17 AceView cDNA sequences:

AI141463 AI376903 AI091419 F26544 AI741640 F35823 AI741629 AA953672

AA928254 AA033827 AI022337 AI458236 AA033884 AI222126 AA621397 AI168267

AI470361

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DHRS7C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCTCCCGGA

About this image
See DHRS7C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DHRS7C

SOURCE GeneReport for Unigene cluster: Hs.61684

SABiosciences Custom PCR Arrays for DHRS7C

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DHRS7C gene from 6/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DHRS7C¹	dehydrogenase/reductase (SDR family) member 7C	72.47(n) 77.42(a)		417304 XM_415576.2 XP_415576.1
lizard (Anolis carolinensis)	Reptilia	DHRS7C⁶	--	73(a)	1 ↔ 1	2(109450661-109462955)
African clawed frog (Xenopus laevis)	Amphibia	Xl.18984²	Xenopus laevis transcribed sequence with weak similarity more	73.89(n)		BJ076645.1
zebrafish (Danio rerio)	Actinopterygii	zgc:112176¹	zgc:112176	63.7(n) 57.43(a)		553684 NM_001020657.1 NP_001018493.1
fruit fly (Drosophila melanogaster)	Insecta	CG7601⁶	--	30(a)	1 → many	3R(25560991-25562542)
worm (Caenorhabditis elegans)	Secernentea	dhs-30⁶ T25G12.13⁶ (see all 3)	--	29(a) 27(a) (see all 3)	many ↔ many many ↔ many (see all 3)	X(17230645-17235763) X(17243283-17244688)

ENSEMBL Gene Tree for DHRS7C (if available)
TreeFam Gene Tree for DHRS7C (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DHRS7C gene

SDR9C7² DHRS9² HSD11B2² HSD17B6² HSD17B2² BDH1² RDH8² RDH16²

DHRS7B² DHRS7² HSD17B1² KDSR² RDH5²

1 SIMAP similar gene for DHRS7C using alignment to 3 protein entries: DRS7C_HUMAN (see all proteins):

DHRS7B

DHRS7C for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183133875^1,2	C,	other	9683146(+)	`CCTTTC/TGTCAA`	4	T	syn¹		0	--	--	--	--
rs142303564^1,2		--	9674251(+)	`TGGCT-/GGTTTA`	2	--	int¹		0	--	--	--	--
rs11654598^1,2	C,A,H,	--	9674275(+)	`TATAAA/TTAAAT`	2	--	int¹		4		NA CSA WA	242
rs144196002^1,2		--	9674467(+)	`CTTGTA/GTACAG`	2	--	int¹		0	--	--	--	--
rs11649844^1,2	C,F,A,H,	--	9674543(+)	`GGTTAC/GAGGCA`	2	--	int¹		21		NS EA NA	2446
rs186856427^1,2		--	9674552(+)	`CATTGA/CAGCTC`	2	--	int¹		0	--	--	--	--
rs188942227^1,2		--	9674782(+)	`AAGGGC/GTGGCC`	2	--	ut3¹		0	--	--	--	--
rs74613314^1,2		--	9674871(+)	`AACTCC/TGGGAA`	4	P	syn¹		0	--	--	--	--
rs140949806^1,2	C,	--	9674874(+)	`TCCGGG/AAAGAA`	4	/F	syn¹		1		EU	569
rs114469918^1,2	C,F,	--	9674901(+)	`GCGGCC/TTTGGG`	4	K	syn¹		1		EU	571

HapMap Linkage Disequilibrium report for DHRS7C (9674751 - 9694614 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DHRS7C
1 CNV: 49950

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DHRS7C for disorders About GeneDecksing

3 diseases for DHRS7C: About MalaCards

pneumonia tuberculosis mycobacterium tuberculosis

Export disorders for DHRS7C gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DHRS7C gene integrated from 9 sources:
(articles sorted by number of sources associating them with DHRS7C)

Utopia: connect your pdf to the dynamic
world of online information

The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)^{1, 3} Persson B.... Oppermann U. (2009)
DHRS7c, a novel cardiomyocyte-expressed gene that is d own-regulated by adrenergic stimulation and in heart failure. (PubMed id 22143674)¹ Lu B....Sillje H.H. (2012)
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)² Zody M.C.... Nusbaum C. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 201140	HGNC: 32423	AceView: LOC201140	Ensembl:ENSG00000184544	euGenes: HUgn201140
ECgene: DHRS7C	H-InvDB: DHRS7C

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DHRS7C	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DHRS7C gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DHRS7C gene:
Search GeneIP for patents involving DHRS7C

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes DHRS7C gene at Home site.

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DHRS7C Gene

dehydrogenase/reductase (SDR family) member 7C

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for DHRS7C gene

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for DHRS7C gene

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Export list of displayed genes

DHRS7C Gene

dehydrogenase/reductase (SDR family) member 7C

Aliasesfor DHRS7C gene

Summariesfor DHRS7C gene

Genomic Viewsfor DHRS7C gene

Proteinsfor DHRS7C gene

Protein Domains /Familiesfor DHRS7C gene

Functionfor DHRS7C gene

Pathways & Interactionsfor DHRS7C gene

Drugs & Compoundsfor DHRS7C gene

Transcriptsfor DHRS7C gene

Expression for DHRS7C gene

Orthologsfor DHRS7C gene

Paralogsfor DHRS7C gene

Genomic Variantsfor DHRS7C gene

Disorders / Diseasesfor DHRS7C gene

Publicationsfor DHRS7C gene

External Searches for DHRS7C gene

Genome Databases showing DHRS7C gene

Other Databases showing DHRS7C gene

Specialized Databases showing DHRS7C gene

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Productsfor DHRS7C gene

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Aliases
for DHRS7C gene

Summaries
for DHRS7C gene

Genomic Views
for DHRS7C gene

Proteins
for DHRS7C gene

Protein Domains /
Families
for DHRS7C gene

Function
for DHRS7C gene

Pathways & Interactions
for DHRS7C gene

Drugs & Compounds
for DHRS7C gene

Transcripts
for DHRS7C gene

Expression
for DHRS7C gene

Orthologs
for DHRS7C gene

Paralogs
for DHRS7C gene

Genomic Variants
for DHRS7C gene

Disorders / Diseases
for DHRS7C gene

Publications
for DHRS7C gene

Intellectual Property
for DHRS7C gene

Products
for DHRS7C gene