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Aliases for DHRS7C Gene

Aliases for DHRS7C Gene

  • Dehydrogenase/Reductase 7C 2 3 5
  • Short-Chain Dehydrogenase/Reductase Family 32C Member 2 3 4
  • Dehydrogenase/Reductase (SDR Family) Member 7C 2 3
  • SDR32C2 3 4
  • Short Chain Dehydrogenase/Reductase Family 32C, Member 2 2
  • Dehydrogenase/Reductase SDR Family Member 7C 3
  • EC 1.1.-.- 4

External Ids for DHRS7C Gene

Previous GeneCards Identifiers for DHRS7C Gene

  • GC17M009616

Summaries for DHRS7C Gene

GeneCards Summary for DHRS7C Gene

DHRS7C (Dehydrogenase/Reductase 7C) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and retinol dehydrogenase activity. An important paralog of this gene is DHRS7B.

UniProtKB/Swiss-Prot for DHRS7C Gene

  • Putative oxidoreductase.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS7C Gene

Genomics for DHRS7C Gene

Regulatory Elements for DHRS7C Gene

Enhancers for DHRS7C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G009837 1.5 FANTOM5 ENCODE dbSUPER 11.5 -46.4 -46378 1.3 TBP KLF17 FEZF1 RAD21 SMARCC2 RCOR1 SMARCC1 ZNF280D CEBPB TSHZ1 MAGOH2P DHRS7C ENSG00000261433 GLP2R GC17P009839 GC17M009835
GH17G009835 1 ENCODE dbSUPER 11.1 -44.5 -44508 1.3 GTF2F1 TBP TAF1 JUN MAX SIN3A RAD21 BRCA1 CTBP1 GATA3 DHRS7C GLP2R GC17M009835 GC17M009822
GH17G009761 0.9 dbSUPER 12.1 +25.6 25619 8.1 TBP PKNOX1 NFIB BRCA1 RAD21 RFX5 ZNF121 SCRT2 ZSCAN5C RCOR1 DHRS7C USP43 ENSG00000282882 GC17M009779
GH17G009828 0.9 FANTOM5 dbSUPER 11.2 -37.1 -37128 0.4 GTF2F1 TBP STAT1 MAFF CEBPB EP300 TCF7L2 ZHX1 DHRS7C GC17M009822 GLP2R
GH17G009829 0.8 ENCODE dbSUPER 11.1 -37.5 -37502 0.2 GTF2F1 TBP STAT1 TCF7L2 ZHX1 DHRS7C GC17M009822 GLP2R
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DHRS7C on UCSC Golden Path with GeneCards custom track

Genomic Location for DHRS7C Gene

Chromosome:
17
Start:
9,771,434 bp from pter
End:
9,791,577 bp from pter
Size:
20,144 bases
Orientation:
Minus strand

Genomic View for DHRS7C Gene

Genes around DHRS7C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHRS7C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHRS7C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS7C Gene

Proteins for DHRS7C Gene

  • Protein details for DHRS7C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NNS2-DRS7C_HUMAN
    Recommended name:
    Dehydrogenase/reductase SDR family member 7C
    Protein Accession:
    A6NNS2
    Secondary Accessions:
    • B7ZW74
    • B9EJH3

    Protein attributes for DHRS7C Gene

    Size:
    312 amino acids
    Molecular mass:
    34878 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI47025.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI47026.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DHRS7C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHRS7C Gene

Post-translational modifications for DHRS7C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHRS7C Gene

No data available for DME Specific Peptides for DHRS7C Gene

Domains & Families for DHRS7C Gene

Gene Families for DHRS7C Gene

Protein Domains for DHRS7C Gene

Suggested Antigen Peptide Sequences for DHRS7C Gene

Graphical View of Domain Structure for InterPro Entry

A6NNS2

UniProtKB/Swiss-Prot:

DRS7C_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS7C: view

Function for DHRS7C Gene

Molecular function for DHRS7C Gene

UniProtKB/Swiss-Prot Function:
Putative oxidoreductase.

Enzyme Numbers (IUBMB) for DHRS7C Gene

Gene Ontology (GO) - Molecular Function for DHRS7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004745 retinol dehydrogenase activity IEA --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with DHRS7C: view

Phenotypes for DHRS7C Gene

genes like me logo Genes that share phenotypes with DHRS7C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DHRS7C Gene

Localization for DHRS7C Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHRS7C Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHRS7C gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 4
plasma membrane 2
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for DHRS7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0014801 longitudinal sarcoplasmic reticulum IEA --
GO:0033017 sarcoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with DHRS7C: view

Pathways & Interactions for DHRS7C Gene

SuperPathways for DHRS7C Gene

No Data Available

Interacting Proteins for DHRS7C Gene

Gene Ontology (GO) - Biological Process for DHRS7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DHRS7C: view

No data available for Pathways by source and SIGNOR curated interactions for DHRS7C Gene

Drugs & Compounds for DHRS7C Gene

No Compound Related Data Available

Transcripts for DHRS7C Gene

mRNA/cDNA for DHRS7C Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DHRS7C Gene

Dehydrogenase/reductase (SDR family) member 7C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS7C Gene

No ASD Table

Relevant External Links for DHRS7C Gene

GeneLoc Exon Structure for
DHRS7C
ECgene alternative splicing isoforms for
DHRS7C

Expression for DHRS7C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHRS7C Gene

mRNA differential expression in normal tissues according to GTEx for DHRS7C Gene

This gene is overexpressed in Heart - Atrial Appendage (x23.2), Muscle - Skeletal (x18.4), and Heart - Left Ventricle (x9.6).

Protein differential expression in normal tissues from HIPED for DHRS7C Gene

This gene is overexpressed in Heart (37.6) and Esophagus (26.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DHRS7C Gene



Protein tissue co-expression partners for DHRS7C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DHRS7C Gene:

DHRS7C

SOURCE GeneReport for Unigene cluster for DHRS7C Gene:

Hs.61684

Evidence on tissue expression from TISSUES for DHRS7C Gene

  • Muscle(2.2)
genes like me logo Genes that share expression patterns with DHRS7C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHRS7C Gene

Orthologs for DHRS7C Gene

This gene was present in the common ancestor of animals.

Orthologs for DHRS7C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHRS7C 34 35
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia DHRS7C 34 35
  • 89.92 (n)
cow
(Bos Taurus)
Mammalia DHRS7C 34 35
  • 88.8 (n)
mouse
(Mus musculus)
Mammalia Dhrs7c 34 16 35
  • 88.09 (n)
rat
(Rattus norvegicus)
Mammalia Dhrs7c 34
  • 87.29 (n)
oppossum
(Monodelphis domestica)
Mammalia DHRS7C 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DHRS7C 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves DHRS7C 34 35
  • 73.45 (n)
lizard
(Anolis carolinensis)
Reptilia DHRS7C 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhrs7c 34
  • 70.92 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18984 34
zebrafish
(Danio rerio)
Actinopterygii dhrs7cb 34 35
  • 64.19 (n)
dhrs7ca 35
  • 47 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8653 34
fruit fly
(Drosophila melanogaster)
Insecta CG7601 35
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dhs-30 35
  • 30 (a)
ManyToMany
T25G12.13 35
  • 27 (a)
ManyToMany
C33E10.10 35
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
OneToMany
Species where no ortholog for DHRS7C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHRS7C Gene

ENSEMBL:
Gene Tree for DHRS7C (if available)
TreeFam:
Gene Tree for DHRS7C (if available)

Paralogs for DHRS7C Gene

(1) SIMAP similar genes for DHRS7C Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DHRS7C: view

Variants for DHRS7C Gene

Sequence variations from dbSNP and Humsavar for DHRS7C Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000113368 -- 9,778,195(+) GACCA(C/T)CCTGG intron-variant
rs1000272721 -- 9,772,586(+) CTACC(A/G)GGTGC intron-variant
rs1000311905 -- 9,783,159(+) AGGTG(C/T)ACTGG intron-variant
rs1000371908 -- 9,789,049(+) ATGAG(A/G)TGTTT intron-variant
rs1000557956 -- 9,784,735(+) AGTAA(C/T)ACATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHRS7C Gene

Variant ID Type Subtype PubMed ID
dgv176n21 CNV loss 19592680
esv3639922 CNV loss 21293372
esv3639923 CNV loss 21293372
nsv1976 CNV deletion 18451855
nsv510697 CNV deletion 20534489
nsv528877 CNV loss 19592680
nsv833358 CNV gain 17160897
nsv833360 CNV loss 17160897
nsv833361 CNV gain 17160897

Variation tolerance for DHRS7C Gene

Residual Variation Intolerance Score: 93.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.71; 73.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHRS7C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DHRS7C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHRS7C Gene

Disorders for DHRS7C Gene

Relevant External Links for DHRS7C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHRS7C

No disorders were found for DHRS7C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHRS7C Gene

Publications for DHRS7C Gene

  1. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3 4 64
  2. DHRS7c, a novel cardiomyocyte-expressed gene that is down-regulated by adrenergic stimulation and in heart failure. (PMID: 22143674) Lu B. … SilljAc H.H. (Eur. J. Heart Fail. 2012) 3 64
  3. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J. … Elledge S.J. (Cell 2009) 3 64
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for DHRS7C Gene

Sources for DHRS7C Gene

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