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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DHRS7C Gene

protein-coding   GIFtS: 42
GCID: GC17M009616

Dehydrogenase/Reductase (SDR Family) Member 7C

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dehydrogenase/Reductase (SDR Family) Member 7C1 2     Dehydrogenase/Reductase SDR Family Member 7C2
Member 21     Short Chain Dehydrogenase/Reductase Family 32C, Member 22
Short Chain Dehydrogenase/Reductase Family 32C1     EC 1.1.-.-3
SDR32C22     

External Ids:    HGNC: 324231   Entrez Gene: 2011402   Ensembl: ENSG000001845447   UniProtKB: A6NNS23   

Export aliases for DHRS7C gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DHRS7C Gene: 
DHRS7C (dehydrogenase/reductase (SDR family) member 7C) is a protein-coding gene. Diseases associated with DHRS7C include pneumonia, and tuberculosis. GO annotations related to this gene include retinol dehydrogenase activity and nucleotide binding. An important paralog of this gene is SDR9C7.

UniProtKB/Swiss-Prot: DRS7C_HUMAN, A6NNS2
Function: Putative oxidoreductase (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DHRS7C gene promoter:
         c-Fos   RFX1   AP-1   AML1a   Ik-3   YY1   E47   C/EBPalpha   S8   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for DHRS7C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHRS7C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

DHRS7C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHRS7C gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M009616:  view genomic region     (about GC identifiers)

Start:
9,674,751 bp from pter      End:
9,694,614 bp from pter
Size:
19,864 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DRS7C_HUMAN, A6NNS2 (See protein sequence)
Recommended Name: Dehydrogenase/reductase SDR family member 7C precursor  
Size: 312 amino acids; 34878 Da
Subcellular location: Secreted (Potential)
Secondary accessions: B7ZW74

Explore the universe of human proteins at neXtProt for DHRS7C: NX_A6NNS2

Explore proteomics data for DHRS7C at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A6NNS2

  • DHRS7C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DHRS7C Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001099041.1  NP_001207422.1  

    ENSEMBL proteins: 
     ENSP00000461902   ENSP00000459579   ENSP00000327975  

    Human Recombinant Protein Products for DHRS7C: 
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    Cloud-Clone Corp. Proteins for DHRS7C 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0014801longitudinal sarcoplasmic reticulum IEA--
    GO:0033017sarcoplasmic reticulum membrane IEA--

    DHRS7C for ontologies           About GeneDecksing



    DHRS7C Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SDRC3: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 3

    4 InterPro protein domains:
     IPR020904 Sc_DH/Rdtase_CS
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry A6NNS2

    ProtoNet protein and cluster: A6NNS2

    UniProtKB/Swiss-Prot: DRS7C_HUMAN, A6NNS2
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    DHRS7C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DRS7C_HUMAN, A6NNS2
    Function: Putative oxidoreductase (Potential)

         Enzyme Number (IUBMB): EC 1.1.-.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004745retinol dehydrogenase activity IEA--
    GO:0016491oxidoreductase activity ----
         
    DHRS7C for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DHRS7C:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DHRS7C 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DHRS7C

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DHRS7C 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHRS7C


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DHRS7C

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----
    GO:0010880regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IEA--

    DHRS7C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DHRS7C (DRS7C)

    Search CenterWatch for drugs/clinical trials and news about DHRS7C / DRS7C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DHRS7C gene (2 alternative transcripts): 
    NM_001105571.2  NM_001220493.1  

    Unigene Cluster for DHRS7C:

    Dehydrogenase/reductase (SDR family) member 7C
    Hs.61684  [show with all ESTs]
    Unigene Representative Sequence: NM_001220493
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000571771 ENST00000571134(uc010cof.3) ENST00000330255(uc010vvb.2)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DHRS7C
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate DHRS7C
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DHRS7C
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    Clone
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    OriGene ORF clones in mouse, rat for DHRS7C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DHRS7C (NM_001105571)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHRS7C
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DHRS7C
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHRS7C

    Additional mRNA sequence: 

    BC147024.1 BC147025.1 BC171909.1 

    2 DOTS entries:

    DT.408581  DT.75102047 

    17 AceView cDNA sequences:

    AI141463 F35823 AI741640 F26544 AA928254 AI741629 AI376903 AA953672 
    AI091419 AA033827 AA033884 AI222126 AI022337 AI458236 AA621397 AI168267 
    AI470361 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DHRS7C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCTCCCGGA
    DHRS7C Expression
    About this image


    See DHRS7C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DHRS7C

    SOURCE GeneReport for Unigene cluster: Hs.61684
        SABiosciences Custom PCR Arrays for DHRS7C
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHRS7C
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHRS7C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DHRS7C gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dhrs7c1 , 5 dehydrogenase/reductase (SDR family) member 7C1, 5 88.21(n)1
    91.32(a)1
      11 (41.13 cM)5
    684601  NM_001013013.21  NP_001013031.21 
     677981875 
    chicken
    (Gallus gallus)
    Aves DHRS7C1 dehydrogenase/reductase (SDR family) member 7C 72.47(n)
    77.42(a)
      417304  XM_415576.2  XP_415576.1 
    lizard
    (Anolis carolinensis)
    Reptilia DHRS7C6
    Uncharacterized protein
    73(a)
    1 ↔ 1
    2(109449699-109465951)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.189842 Xenopus laevis transcribed sequence with weak similarity more 73.89(n)    BJ076645.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1121761 zgc:112176 63.7(n)
    57.43(a)
      553684  NM_001020657.1  NP_001018493.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG76016
    --
    31(a)
    1 → many
    3R(25560991-25562542)
    worm
    (Caenorhabditis elegans)
    Secernentea dhs-306
    T25G12.136
    (see all 3)
    Protein T25G12.13
    (see all 3)
    30(a)
    27(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    X(17230719-17235837)
    X(17243357-17244762)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LYS26
    Alpha aminoadipate reductase, catalyzes the reduct...
    4(a)
    1 → many
    II(469748-473926)


    ENSEMBL Gene Tree for DHRS7C (if available)
    TreeFam Gene Tree for DHRS7C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DHRS7C gene
    SDR9C72  DHRS92  HSD11B22  HSD17B62  HSD17B22  BDH12  RDH82  RDH162  
    DHRS7B2  DHRS72  HSD17B12  KDSR2  RDH52  
    1 SIMAP similar gene for DHRS7C using alignment to 3 protein entries:     DRS7C_HUMAN (see all proteins):
    DHRS7B

    DHRS7C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/509 SNPs in DHRS7C are shown (see all 509)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1831338751,2
    Cuntested19683146(+) CCTTTC/TGTCAA 4 T syn10--------
    rs1423035641,2
    --9674251(+) TGGCT-/GGTTTA 2 -- int10--------
    rs116545981,2
    C,A,H--9674275(+) TATAAA/TTAAAT 2 -- int14Minor allele frequency- T:0.08NA CSA WA 242
    rs1441960021,2
    C--9674467(+) CTTGTA/GTACAG 2 -- int10--------
    rs116498441,2
    C,F,A,H--9674543(+) GGTTAC/GAGGCA 2 -- int121Minor allele frequency- G:0.05NS EA NA 2446
    rs1868564271,2
    --9674552(+) CATTGA/CAGCTC 2 -- int10--------
    rs1889422271,2
    C--9674782(+) AAGGGC/GTGGCC 2 -- ut310--------
    rs1997087381,2
    C--9674818(+) CCTCCG/AGGACA 4 /P /L mis11Minor allele frequency- A:0.00EU 569
    rs1998416581,2
    C--9674858(+) CACGGC/TGAAAA 4 T A mis10--------
    rs746133141,2
    C,F--9674871(+) AACTCC/TGGGAA 4 P syn10--------

    HapMap Linkage Disequilibrium report for DHRS7C (9674751 - 9694614 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for DHRS7C:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv528877CNV Loss19592680
    nsv1976CNV Loss18451855
    dgv176n21CNV Loss19592680
    nsv510697CNV Loss20534489
    nsv833360CNV Loss17160897
    nsv833361CNV Gain17160897
    nsv833358CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for DHRS7C:    About MalaCards
    pneumonia    tuberculosis


    DHRS7C for disorders           About GeneDecksing


    Export disorders for DHRS7C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DHRS7C gene integrated from 9 sources:
    (articles sorted by number of sources associating them with DHRS7C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (2009)
    2. DHRS7c, a novel cardiomyocyte-expressed gene that is d own-regulated by adrenergic stimulation and in heart failure. (PubMed id 22143674)1 Lu B....Sillje H.H. (2012)
    3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 201140 HGNC: 32423 AceView: LOC201140 Ensembl:ENSG00000184544 euGenes: HUgn201140
    ECgene: DHRS7C H-InvDB: DHRS7C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DHRS7C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DHRS7C gene:
    Search GeneIP for patents involving DHRS7C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Regulatory tfbs in DHRS7C promoter
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     Proteins for DHRS7C
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     inGenious Targeting Laboratory - Custom generated mouse model solutions for DHRS7C
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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