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Aliases for DHRS7C Gene

Aliases for DHRS7C Gene

  • Dehydrogenase/Reductase (SDR Family) Member 7C 2 3
  • Short-Chain Dehydrogenase/Reductase Family 32C Member 2 3 4
  • SDR32C2 3 4
  • Short Chain Dehydrogenase/Reductase Family 32C, Member 2 3
  • Short Chain Dehydrogenase/Reductase Family 32C 2
  • EC 1.1.-.- 4
  • Member 2 2

External Ids for DHRS7C Gene

Previous GeneCards Identifiers for DHRS7C Gene

  • GC17M009616

Summaries for DHRS7C Gene

GeneCards Summary for DHRS7C Gene

DHRS7C (Dehydrogenase/Reductase (SDR Family) Member 7C) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and retinol dehydrogenase activity. An important paralog of this gene is HSD11B2.

UniProtKB/Swiss-Prot for DHRS7C Gene

  • Putative oxidoreductase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS7C Gene

Genomics for DHRS7C Gene

Regulatory Elements for DHRS7C Gene

Genomic Location for DHRS7C Gene

Chromosome:
17
Start:
9,771,434 bp from pter
End:
9,791,577 bp from pter
Size:
20,144 bases
Orientation:
Minus strand

Genomic View for DHRS7C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHRS7C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS7C Gene

Proteins for DHRS7C Gene

  • Protein details for DHRS7C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NNS2-DRS7C_HUMAN
    Recommended name:
    Dehydrogenase/reductase SDR family member 7C
    Protein Accession:
    A6NNS2
    Secondary Accessions:
    • B7ZW74
    • B9EJH3

    Protein attributes for DHRS7C Gene

    Size:
    312 amino acids
    Molecular mass:
    34878 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI47025.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI47026.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DHRS7C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHRS7C Gene

Proteomics data for DHRS7C Gene at MOPED

Post-translational modifications for DHRS7C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHRS7C Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for DHRS7C

No data available for DME Specific Peptides for DHRS7C Gene

Domains & Families for DHRS7C Gene

Gene Families for DHRS7C Gene

Protein Domains for DHRS7C Gene

Suggested Antigen Peptide Sequences for DHRS7C Gene

Graphical View of Domain Structure for InterPro Entry

A6NNS2

UniProtKB/Swiss-Prot:

DRS7C_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS7C: view

Function for DHRS7C Gene

Molecular function for DHRS7C Gene

UniProtKB/Swiss-Prot Function:
Putative oxidoreductase.

Enzyme Numbers (IUBMB) for DHRS7C Gene

Gene Ontology (GO) - Molecular Function for DHRS7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004745 retinol dehydrogenase activity IEA --
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with DHRS7C: view

Phenotypes for DHRS7C Gene

GenomeRNAi human phenotypes for DHRS7C:
genes like me logo Genes that share phenotypes with DHRS7C: view

Animal Model Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DHRS7C Gene

Localization for DHRS7C Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHRS7C Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHRS7C Gene COMPARTMENTS Subcellular localization image for DHRS7C gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for DHRS7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0014801 longitudinal sarcoplasmic reticulum IEA --
GO:0033017 sarcoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with DHRS7C: view

Pathways & Interactions for DHRS7C Gene

SuperPathways for DHRS7C Gene

No Data Available

Interacting Proteins for DHRS7C Gene

Gene Ontology (GO) - Biological Process for DHRS7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DHRS7C: view

No data available for Pathways by source and SIGNOR curated interactions for DHRS7C Gene

Drugs & Compounds for DHRS7C Gene

No Compound Related Data Available

Transcripts for DHRS7C Gene

mRNA/cDNA for DHRS7C Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DHRS7C Gene

Dehydrogenase/reductase (SDR family) member 7C:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DHRS7C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS7C Gene

No ASD Table

Relevant External Links for DHRS7C Gene

GeneLoc Exon Structure for
DHRS7C
ECgene alternative splicing isoforms for
DHRS7C

Expression for DHRS7C Gene

mRNA expression in normal human tissues for DHRS7C Gene

mRNA differential expression in normal tissues according to GTEx for DHRS7C Gene

This gene is overexpressed in Heart - Atrial Appendage (x23.2), Muscle - Skeletal (x18.4), and Heart - Left Ventricle (x9.6).

Protein differential expression in normal tissues from HIPED for DHRS7C Gene

This gene is overexpressed in Heart (37.6) and Esophagus (26.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DHRS7C Gene



SOURCE GeneReport for Unigene cluster for DHRS7C Gene Hs.61684

genes like me logo Genes that share expression patterns with DHRS7C: view

Protein tissue co-expression partners for DHRS7C Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DHRS7C Gene

Orthologs for DHRS7C Gene

This gene was present in the common ancestor of animals.

Orthologs for DHRS7C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DHRS7C 35
  • 88.8 (n)
  • 93.05 (a)
DHRS7C 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DHRS7C 35
  • 89.92 (n)
  • 95.5 (a)
DHRS7C 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dhrs7c 35
  • 88.09 (n)
  • 91.41 (a)
Dhrs7c 16
Dhrs7c 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DHRS7C 35
  • 99.46 (n)
  • 100 (a)
DHRS7C 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dhrs7c 35
  • 87.29 (n)
  • 90.38 (a)
oppossum
(Monodelphis domestica)
Mammalia DHRS7C 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DHRS7C 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves DHRS7C 35
  • 73.45 (n)
  • 78.28 (a)
DHRS7C 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHRS7C 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhrs7c 35
  • 70.92 (n)
  • 78.97 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18984 35
zebrafish
(Danio rerio)
Actinopterygii dhrs7cb 35
  • 64.19 (n)
  • 59.01 (a)
dhrs7ca 36
  • 47 (a)
OneToMany
dhrs7cb 36
  • 54 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8653 35
fruit fly
(Drosophila melanogaster)
Insecta CG7601 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C33E10.10 36
  • 24 (a)
ManyToMany
dhs-30 36
  • 30 (a)
ManyToMany
T25G12.13 36
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToMany
Species with no ortholog for DHRS7C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHRS7C Gene

ENSEMBL:
Gene Tree for DHRS7C (if available)
TreeFam:
Gene Tree for DHRS7C (if available)

Paralogs for DHRS7C Gene

(1) SIMAP similar genes for DHRS7C Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DHRS7C: view

Variants for DHRS7C Gene

Sequence variations from dbSNP and Humsavar for DHRS7C Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs708584 -- 9,780,108(-) TTTTA(A/G)ATCGA intron-variant
rs1554462 -- 9,781,542(+) CAGTT(A/C/T)TTTCC synonymous-codon, reference, missense
rs2001384 -- 9,775,312(+) GCCCA(A/T)TCACT intron-variant
rs2001810 -- 9,776,022(-) GTTTC(A/C)CCATA intron-variant
rs2272032 -- 9,777,362(-) GTACC(A/G)GGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHRS7C Gene

Variant ID Type Subtype PubMed ID
nsv833358 CNV Gain 17160897
nsv510697 CNV Loss 20534489
nsv833360 CNV Loss 17160897
dgv176n21 CNV Loss 19592680
nsv528877 CNV Loss 19592680
nsv1976 CNV Loss 18451855
nsv833361 CNV Gain 17160897

Variation tolerance for DHRS7C Gene

Residual Variation Intolerance Score: 93.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.71; 73.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHRS7C Gene

HapMap Linkage Disequilibrium report
DHRS7C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHRS7C Gene

Disorders for DHRS7C Gene

Relevant External Links for DHRS7C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHRS7C
genes like me logo Genes that share disorders with DHRS7C: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHRS7C Gene

Publications for DHRS7C Gene

  1. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 67
  2. DHRS7c, a novel cardiomyocyte-expressed gene that is down-regulated by adrenergic stimulation and in heart failure. (PMID: 22143674) Lu B. … SilljAc H.H. (Eur. J. Heart Fail. 2012) 67
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for DHRS7C Gene

Sources for DHRS7C Gene

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