Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DHRS7B Gene

protein-coding   GIFtS: 48
GCID: GC17P022221

Dehydrogenase/Reductase (SDR Family) Member 7B

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Dehydrogenase/Reductase (SDR Family) Member 7B1 2     Dehydrogenase/Reductase SDR Family Member 7B2
Member 11     Short Chain Dehydrogenase/Reductase Family 32C, Member 12
Short Chain Dehydrogenase/Reductase Family 32C1     EC 1.1.-.-3
SDR32C12     

External Ids:    HGNC: 245471   Entrez Gene: 259792   Ensembl: ENSG000001090167   UniProtKB: Q6IAN03   

Export aliases for DHRS7B gene to outside databases

Previous GC identifers: GC17P020971 GC17P021030 GC17P020232 GC17P021269 GC17P021531


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DHRS7B Gene:
This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown
function. (provided by RefSeq, Jul 2008)

GeneCards Summary for DHRS7B Gene:
DHRS7B (dehydrogenase/reductase (SDR family) member 7B) is a protein-coding gene. Diseases associated with DHRS7B include smith magenis syndrome, and pneumonia. GO annotations related to this gene include oxidoreductase activity. An important paralog of this gene is SDR9C7.

UniProtKB/Swiss-Prot: DRS7B_HUMAN, Q6IAN0
Function: Putative oxidoreductase (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000017.11  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DHRS7B gene promoter:
         Elk-1   Pbx1a   Pax-5   NRF-2   c-Ets-1   Gfi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDHRS7B promoter sequence
   Search Chromatin IP Primers for DHRS7B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DHRS7B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p12   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p12

DHRS7B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHRS7B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P022221:  view genomic region     (about GC identifiers)

Start:
21,026,677 bp from pter      End:
21,096,578 bp from pter
Size:
69,902 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DRS7B_HUMAN, Q6IAN0 (See protein sequence)
Recommended Name: Dehydrogenase/reductase SDR family member 7B  
Size: 325 amino acids; 35119 Da
Sequence caution: Sequence=AAD34088.1; Type=Frameshift; Positions=12, 266; Sequence=AAQ88862.1; Type=Erroneous
initiation;
Secondary accessions: B5MEF4 Q6UX59 Q9BTF9 Q9UFM6 Q9Y3A1

Explore the universe of human proteins at neXtProt for DHRS7B: NX_Q6IAN0

Explore proteomics data for DHRS7B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys183
  • Modification sites at PhosphoSitePlus

  • See DHRS7B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056325.2  
    ENSEMBL proteins: 
     ENSP00000463221   ENSP00000378887   ENSP00000463591   ENSP00000468585   ENSP00000462139  
     ENSP00000463588  

    DHRS7B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DHRS7B
    OriGene Protein Over-expression Lysate for DHRS7B
    OriGene MassSpec for DHRS7B
    OriGene Custom Protein Services for DHRS7B
    GenScript Custom Purified and Recombinant Proteins Services for DHRS7B
    Novus Biologicals DHRS7B Protein
    Novus Biologicals DHRS7B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DHRS7B

    DHRS7B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DHRS7B
    Novus Biologicals DHRS7B Antibodies
    Abcam antibodies for DHRS7B
    Cloud-Clone Corp. Antibodies for DHRS7B
    Search ThermoFisher Antibodies for DHRS7B
    LSBio Antibodies in human, mouse, rat for DHRS7B

    DHRS7B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DHRS7B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DHRS7B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DHRS7B
    Cloud-Clone Corp. CLIAs for DHRS7B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SDRC3: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 3

    4 InterPro protein domains:
     IPR020904 Sc_DH/Rdtase_CS
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q6IAN0

    ProtoNet protein and cluster: Q6IAN0

    2 Blocks protein domains:
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature


    UniProtKB/Swiss-Prot: DRS7B_HUMAN, Q6IAN0
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    DHRS7B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DRS7B_HUMAN, Q6IAN0
    Function: Putative oxidoreductase (Potential)

         Enzyme Number (IUBMB): EC 1.1.-.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0016491oxidoreductase activity IEA--
         
    DHRS7B for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dhrs7b):
     digestive/alimentary  hematopoietic system  immune system  mortality/aging  muscle 

    DHRS7B for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DHRS7B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DHRS7B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DHRS7B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DHRS7B

    miRNA
    Products:
        
    miRTarBase miRNAs that target DHRS7B:
    hsa-mir-92a-3p (MIRT049736)

    Block miRNA regulation of human, mouse, rat DHRS7B using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate DHRS7B:
    hsa-miR-188-3p hsa-miR-1260b hsa-miR-3065-5p hsa-miR-1260
    SwitchGear 3'UTR luciferase reporter plasmidDHRS7B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DHRS7B
    Predesigned siRNA for gene silencing in human, mouse, rat DHRS7B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DHRS7B

    Clone
    Products:
         
    OriGene clones in human, mouse for DHRS7B (see all 6)
    OriGene ORF clones in mouse, rat for DHRS7B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DHRS7B (NM_015510)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHRS7B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHRS7B

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DHRS7B
    Browse ESI BIO Cell Lines and PureStem Progenitors for DHRS7B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHRS7B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DRS7B_HUMAN, Q6IAN0: Peroxisome membrane; Single-pass type II membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    peroxisome5
    golgi apparatus3
    nucleus3
    plasma membrane3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005778peroxisomal membrane IEA--
    GO:0016021integral component of membrane IEA--

    DHRS7B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DHRS7B
    Interactions:

        Search GeneGlobe Interaction Network for DHRS7B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for DHRS7B (Q6IAN02, 3 ENSP000003788874) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED19A0JLT22, 3, ENSP000003373404STRING: ENSP00000337340 MINT-64898 I2D: score=4 
    BREQ9NXR73, ENSP000003434124I2D: score=2 STRING: ENSP00000343412
    ATG101Q9BSB43I2D: score=1 
    ATG2AQ2TAZ03I2D: score=1 
    BECN1Q144573I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0008152metabolic process ----

    DHRS7B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DHRS7B (DRS7B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DHRS7B gene: 
    NM_015510.4  

    Unigene Cluster for DHRS7B:

    Dehydrogenase/reductase (SDR family) member 7B
    Hs.386989  [show with all ESTs]
    Unigene Representative Sequence: NM_015510
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000582161 ENST00000395511(uc002gyo.3) ENST00000579099 ENST00000578426
    ENST00000581020 ENST00000579303 ENST00000577350(uc010crc.1) ENST00000346603
    ENST00000583388 ENST00000581463
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DHRS7B using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate DHRS7B:
    hsa-miR-188-3p hsa-miR-1260b hsa-miR-3065-5p hsa-miR-1260
    SwitchGear 3'UTR luciferase reporter plasmidDHRS7B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DHRS7B
    Predesigned siRNA for gene silencing in human, mouse, rat DHRS7B
    Clone
    Products:
         
    OriGene clones in human, mouse for DHRS7B (see all 6)
    OriGene ORF clones in mouse, rat for DHRS7B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DHRS7B (NM_015510)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHRS7B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHRS7B
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DHRS7B
    OriGene qSTAR qPCR primer pairs in human, mouse for DHRS7B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DHRS7B
      QuantiTect SYBR Green Assays in human, mouse, rat DHRS7B
      QuantiFast Probe-based Assays in human, mouse, rat DHRS7B

    Additional mRNA sequence: 

    AF151851.1 AK309867.1 AL117567.1 AY358498.2 BC004126.2 BC009679.2 CR457124.1 

    8 DOTS entries:

    DT.316950  DT.100711625  DT.101962447  DT.95369191  DT.97779217  DT.97817969  DT.100779878  DT.120657567 

    Selected AceView cDNA sequences (see all 149):

    CD109062 CB156168 BU183260 AI362706 CB156151 AI571677 AW009052 AA506577 
    AI955891 AI088401 AI811602 BE785725 BU951981 CB215380 AI870558 BX090750 
    BE390506 CA396401 C00495 BI335291 BM724640 BI908113 AI024926 BI560643 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DHRS7B (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
    SP1:              -     -     -           -     -                                                   
    SP2:              -     -     -           -     -     -     -                                       
    SP3:                                                                                                
    SP4:                          -           -     -                                                   
    SP5:                                      -     -                                                   


    ECgene alternative splicing isoforms for DHRS7B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DHRS7B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTCCAGGG
    DHRS7B Expression
    About this image

    DHRS7B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DHRS7B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.386989
        Custom PCR Arrays for DHRS7B
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DHRS7B
    OriGene qSTAR qPCR primer pairs in human, mouse for DHRS7B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DHRS7B
    QuantiTect SYBR Green Assays in human, mouse, rat DHRS7B
    QuantiFast Probe-based Assays in human, mouse, rat DHRS7B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHRS7B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for DHRS7B gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dhrs7b1 , 5 dehydrogenase/reductase (SDR family) member 7B1, 5 82.46(n)1
    78.02(a)1
      11 (37.87 cM)5
    2168201  NM_145428.21  NP_663403.11 
     608306795 
    chicken
    (Gallus gallus)
    Aves DHRS7B1 dehydrogenase/reductase (SDR family) member 7B 71.3(n)
    71.6(a)
      416499  XM_004945174.1  XP_004945231.1 
    lizard
    (Anolis carolinensis)
    Reptilia DHRS7B6
    dehydrogenase/reductase (SDR family) member 7B
    59(a)
    1 ↔ 1
    GL343385.1(826888-836376)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.18062 Transcribed sequence with weak similarity to protein more 74.49(n)    CF378098.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.144242 Transcribed sequence with weak similarity to protein more 72.6(n)    BI840733.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG76011 CG7601 51.55(n)
    46.03(a)
      43502  NM_143460.3  NP_651717.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dhs-301 dhs-30 49.23(n)
    41.34(a)
      181761  NM_078392.4  NP_510793.2 


    ENSEMBL Gene Tree for DHRS7B (if available)
    TreeFam Gene Tree for DHRS7B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DHRS7B gene
    SDR9C72  DHRS92  HSD11B22  HSD17B62  HSD17B22  BDH12  RDH162  RDH82  
    DHRS72  HSD17B12  KDSR2  DHRS7C2  RDH52  
    3 SIMAP similar genes for DHRS7B using alignment to 5 protein entries:     DRS7B_HUMAN (see all proteins):
    DHRS7C    DHRS7    DKFZp564H1664

    DHRS7B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DHRS7B (see all 1237)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1424728821,2
    --21028357(+) CTTTGA/TAATAT 1 -- us2k10--------
    rs1128883391,2
    C--21028421(+) AGAGGG/ATAGCA 1 -- us2k12Minor allele frequency- A:0.04CSA WA 120
    rs1513227351,2
    --21028465(+) GTCATG/TCAATA 1 -- us2k10--------
    rs1405875111,2
    --21028480(+) CTCAGA/GTGTTA 1 -- us2k10--------
    rs1844695641,2
    --21028486(+) TGTTAC/TCAGTG 1 -- us2k10--------
    rs1159959891,2
    C,F--21028513(+) TTGGCG/ATTTTG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1162379301,2
    F--21028588(+) TTATTG/AAAAAC 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1905487141,2
    --21028678(+) ACCCTC/GTAGAG 1 -- us2k10--------
    rs1824313451,2
    --21028681(+) CTCTAA/GAGGGT 1 -- us2k10--------
    rs1155837321,2
    F--21028765(+) GGGGAC/ACAATC 1 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for DHRS7B (21026677 - 21096578 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DHRS7B: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DHRS7B
    DNA2.0 Custom Variant and Variant Library Synthesis for DHRS7B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    4 diseases for DHRS7B:    
    About MalaCards
    smith magenis syndrome    pneumonia    tuberculosis    malaria


    DHRS7B for disorders           About GeneDecksing


    Export disorders for DHRS7B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DHRS7B gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with DHRS7B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    3. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (Chem. Biol. Interact. 2009)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Genome-wide association study identifies loci affecting blood copper, selenium and zinc. (PubMed id 23720494)1 Evans D.M....Whitfield J.B. (Hum. Mol. Genet. 2013)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    8. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 25979 HGNC: 24547 AceView: DKFZp566O084 Ensembl:ENSG00000109016 euGenes: HUgn25979
    ECgene: DHRS7B H-InvDB: DHRS7B

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DHRS7B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DHRS7B gene:
    Search GeneIP for patents involving DHRS7B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DHRS7B  
     OriGene qPCR primer pairs and template standards for DHRS7B   OriGene Protein Over-expression Lysate for DHRS7B  
     OriGene MassSpec something-or-other for DHRS7B   OriGene clones in human, mouse for DHRS7B  
     OriGene qSTAR qPCR primer pairs in human, mouse for DHRS7B   OriGene Purified Protein for DHRS7B  
     OriGene ORF clones in mouse, rat for DHRS7B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DHRS7B   OriGene Custom Protein Services for DHRS7B  

     
     
     Block miRNA regulation of human, mouse, rat DHRS7B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DHRS7B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DHRS7B Predesigned siRNA for gene silencing in human, mouse, rat DHRS7B
     QuantiFast Probe-based Assays in human, mouse, rat DHRS7B QuantiTect SYBR Green Assays in human, mouse, rat DHRS7B
     Custom PCR Arrays for DHRS7B Search Chromatin IP Primers for DHRS7B
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DHRS7B  Search GeneGlobe Interaction Network for DHRS7B
     Regulatory tfbs in DHRS7B promoter
     GenScript Custom Purified and Recombinant Proteins Services for DHRS7B GenScript cDNA clones with any tag delivered in your preferred vector for DHRS7B
     GenScript Custom Assay Services for DHRS7B GenScript Custom overexpressing Cell Line Services for DHRS7B
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DHRS7B (DRS7B)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DHRS7B antibodies
     DHRS7B proteins
     DHRS7B lysates
     Antibodies for DHRS7B
     See all of Abcam's Antibodies, Kits and Proteins for DHRS7B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for DHRS7B
     Antibodies for DHRS7B
     ELISAs for DHRS7B
     CLIAs for DHRS7B



     Browse ESI BIO Cell Lines and PureStem Progenitors for DHRS7B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHRS7B
     SwitchGear 3'UTR luciferase reporter plasmids for DHRS7B
     SwitchGear Promoter luciferase reporter plasmids for DHRS7B
     Search ThermoFisher Antibodies for DHRS7B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHRS7B
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DHRS7B
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DHRS7B
     LSBio Antibodies in human, mouse, rat for DHRS7B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DHRS7B gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4