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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DHRS7B Gene

protein-coding   GIFtS: 45
GCID: GC17P021269

dehydrogenase/reductase (SDR family) member 7B

 Explore 4 diseases affiliated with
DHRS7B via our new
 Human Malady Compendium 
Biological research products
for DHRS7B
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Dehydrogenase/Reductase (SDR Family) Member 7B1 2     MGC89161
SDR32C11 2     Dehydrogenase/Reductase SDR Family Member 7B2
CGI-931     Short Chain Dehydrogenase/Reductase Family 32C, Member 12
DKFZp566O0841     EC 1.1.-.-3

External Ids:    HGNC: 245471   Entrez Gene: 259792   Ensembl: ENSG000001090167   UniProtKB: Q6IAN03   

Export aliases for DHRS7B gene to outside databases

Previous GC identifers: GC17P020971 GC17P021030 GC17P020232


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DHRS7B:
This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown
function. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DRS7B_HUMAN, Q6IAN0
Function: Putative oxidoreductase (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DHRS7B gene promoter:
         Elk-1   Pbx1a   Pax-5   NRF-2   c-Ets-1   Gfi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDHRS7B promoter sequence
   Search SABiosciences Chromatin IP Primers for DHRS7B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHRS7B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p12   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p12

DHRS7B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHRS7B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P021269:  view genomic region     (about GC identifiers)

Start:
21,026,677 bp from pter      End:
21,096,578 bp from pter
Size:
69,902 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DRS7B_HUMAN, Q6IAN0 (See protein sequence)
Recommended Name: Dehydrogenase/reductase SDR family member 7B  
Size: 325 amino acids; 35119 Da
Subcellular location: Peroxisome membrane; Single-pass type II membrane protein (Potential)
Sequence caution: Sequence=AAD34088.1; Type=Frameshift; Positions=12, 266; Sequence=AAQ88862.1; Type=Erroneous
initiation;
Secondary accessions: B5MEF4 Q6UX59 Q9BTF9 Q9UFM6 Q9Y3A1

Explore the universe of human proteins at neXtProt for DHRS7B: NX_Q6IAN0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6IAN0

  • DHRS7B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_056325.2  
    ENSEMBL proteins: 
     ENSP00000463221   ENSP00000378887   ENSP00000463591   ENSP00000468585   ENSP00000462139  
     ENSP00000463588  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DHRS7B

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005778peroxisomal membrane IEA--
    GO:0016021integral to membrane IEA--


    DHRS7B for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    DHRS7B for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR020904 Sc_DH/Rdtase_CS
     IPR016040 NAD(P)-bd_dom
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR

    Graphical View of Domain Structure for InterPro Entry Q6IAN0

    ProtoNet protein and cluster: Q6IAN0

    2 Blocks protein families:
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature


    UniProtKB/Swiss-Prot: DRS7B_HUMAN, Q6IAN0
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: DRS7B_HUMAN, Q6IAN0
    Function: Putative oxidoreductase (Potential)

    Enzyme Number (IUBMB): EC 1.1.-.-1

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    hsa-miR-188-3p hsa-miR-1260b hsa-miR-3065-5p hsa-miR-1260
    SwitchGear 3'UTR luciferase reporter plasmidDHRS7B 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003674molecular_function ND--
    GO:0016491oxidoreductase activity IEA--


    DHRS7B for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DHRS7B

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/11 Interacting proteins for DHRS7B (Q6IAN02, 3 ENSP000003788874) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED19A0JLT22, 3, ENSP000003373404STRING: ENSP00000337340 MINT-64898 I2D: score=4 
    BREQ9NXR73, ENSP000003434124I2D: score=2 STRING: ENSP00000343412
    ATG2AQ2TAZ03I2D: score=1 
    BECN1Q144573I2D: score=1 
    C12orf44Q9BSB43I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--


    DHRS7B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DHRS7B
    Search CenterWatch for drugs/clinical trials and news about DHRS7B / DRS7B 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DHRS7B gene: 
    NM_015510.4  

    Unigene Cluster for DHRS7B:

    Dehydrogenase/reductase (SDR family) member 7B
    Hs.386989  [show with all ESTs]
    Unigene Representative Sequence: NM_015510
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000582161 ENST00000395511(uc002gyo.3) ENST00000579099 ENST00000578426
    ENST00000581020 ENST00000579303 ENST00000577350(uc010crc.1) ENST00000346603
    ENST00000583388 ENST00000581463

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    hsa-miR-188-3p hsa-miR-1260b hsa-miR-3065-5p hsa-miR-1260
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    Inhib. RNA
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    Additional cDNA sequence: 

    AF151851.1 AK309867.1 AL117567.1 AY358498.2 BC004126.2 BC009679.2 CR457124.1 

    8 DOTS entries:

    DT.316950  DT.100711625  DT.101962447  DT.95369191  DT.97779217  DT.97817969  DT.100779878  DT.120657567 

    24/149 AceView cDNA sequences (see all 149):

    AI811602 AI955891 CD109062 CB156151 AA622681 CF128078 CA487694 BU951981 
    BC004126 BE856188 BQ016984 AA552108 BM854599 AA588512 BQ677654 BE390506 
    AI024926 BI335291 BI560643 BI908113 CD108362 C00495 BX090750 AA506577 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for DHRS7B (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
    SP1:              -     -     -           -     -                                                   
    SP2:              -     -     -           -     -     -     -                                       
    SP3:                                                                                                
    SP4:                          -           -     -                                                   
    SP5:                                      -     -                                                   


    ECgene alternative splicing isoforms for DHRS7B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DHRS7B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCTCCAGGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See DHRS7B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DHRS7B

    SOURCE GeneReport for Unigene cluster: Hs.386989
        SABiosciences Custom PCR Arrays for DHRS7B
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DHRS7B gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves DHRS7B1 dehydrogenase/reductase (SDR family) member 7B 71.66(n)
    72.96(a)
      416499  XM_414804.3  XP_414804.1 
    lizard
    (Anolis carolinensis)
    Reptilia DHRS7B6
    --
    66(a)
    1 ↔ 1
    GL343385.1(832172-834473)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.18062 Transcribed sequence with weak similarity to protein more 74.49(n)    CF378098.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.144242 Transcribed sequence with weak similarity to protein more 72.6(n)    BI840733.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG76011 CG7601 51.55(n)
    46.03(a)
      43502  NM_143460.3  NP_651717.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dhs-301 Protein DHS-30 49.23(n)
    41.34(a)
      181761  NM_078392.3  NP_510793.2 


    ENSEMBL Gene Tree for DHRS7B (if available)
    TreeFam Gene Tree for DHRS7B (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DHRS7B gene
    SDR9C72  DHRS92  HSD11B22  HSD17B62  HSD17B22  BDH12  RDH82  RDH162  
    DHRS72  HSD17B12  KDSR2  DHRS7C2  RDH52  
    3 SIMAP similar genes for DHRS7B using alignment to 5 protein entries:     DRS7B_HUMAN (see all proteins):
    DHRS7C    DHRS7    DKFZp564H1664

    DHRS7B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1041 NCBI SNPs in DHRS7B are shown (see all 1041    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1424728821,2
    --21028357(+) CTTTGA/TAATAT 1 -- us2k10--------
    rs1128883391,2
    C,--21028421(+) AGAGGG/ATAGCA 1 -- us2k12Minor allele frequency- A:0.04CSA WA 120
    rs1513227351,2
    --21028465(+) GTCATG/TCAATA 1 -- us2k10--------
    rs1405875111,2
    --21028480(+) CTCAGA/GTGTTA 1 -- us2k10--------
    rs1844695641,2
    --21028486(+) TGTTAC/TCAGTG 1 -- us2k10--------
    rs1159959891,2
    F,--21028513(+) TTGGCG/ATTTTG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1162379301,2
    F,--21028588(+) TTATTG/AAAAAC 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1905487141,2
    --21028678(+) ACCCTC/GTAGAG 1 -- us2k10--------
    rs1824313451,2
    --21028681(+) CTCTAA/GAGGGT 1 -- us2k10--------
    rs1155837321,2
    F,--21028765(+) GGGGAC/ACAATC 1 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for DHRS7B (21026677 - 21096578 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DHRS7B: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DHRS7B
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DHRS7B for disorders           About GeneDecksing

    4 diseases for DHRS7B:    About MalaCards
    smith-magenis syndrome    pneumonia    tuberculosis    mycobacterium tuberculosis


    Export disorders for DHRS7B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DHRS7B gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with DHRS7B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
    3. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (2009)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25979 HGNC: 24547 AceView: DKFZp566O084 Ensembl:ENSG00000109016 euGenes: HUgn25979
    ECgene: DHRS7B H-InvDB: DHRS7B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DHRS7B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DHRS7B gene:
    Search GeneIP for patents involving DHRS7B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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