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Aliases for DHRS7B Gene

Aliases for DHRS7B Gene

  • Dehydrogenase/Reductase (SDR Family) Member 7B 2 3 5
  • Short-Chain Dehydrogenase/Reductase Family 32C Member 1 3 4
  • SDR32C1 3 4
  • Short Chain Dehydrogenase/Reductase Family 32C, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 32C 2
  • EC 1.1.-.- 4
  • Member 1 2
  • CGI-93 3

External Ids for DHRS7B Gene

Previous GeneCards Identifiers for DHRS7B Gene

  • GC17P020971
  • GC17P021030
  • GC17P020232
  • GC17P021269
  • GC17P021531
  • GC17P022221
  • GC17P021672
  • GC17P021844

Summaries for DHRS7B Gene

Entrez Gene Summary for DHRS7B Gene

  • This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function. [provided by RefSeq, Jul 2008]

GeneCards Summary for DHRS7B Gene

DHRS7B (Dehydrogenase/Reductase (SDR Family) Member 7B) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity. An important paralog of this gene is DHRS7C.

UniProtKB/Swiss-Prot for DHRS7B Gene

  • Putative oxidoreductase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS7B Gene

Genomics for DHRS7B Gene

Regulatory Elements for DHRS7B Gene

Genomic Location for DHRS7B Gene

Chromosome:
17
Start:
21,123,364 bp from pter
End:
21,193,265 bp from pter
Size:
69,902 bases
Orientation:
Plus strand

Genomic View for DHRS7B Gene

Genes around DHRS7B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHRS7B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHRS7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS7B Gene

Proteins for DHRS7B Gene

  • Protein details for DHRS7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IAN0-DRS7B_HUMAN
    Recommended name:
    Dehydrogenase/reductase SDR family member 7B
    Protein Accession:
    Q6IAN0
    Secondary Accessions:
    • B5MEF4
    • Q6UX59
    • Q9BTF9
    • Q9UFM6
    • Q9Y3A1

    Protein attributes for DHRS7B Gene

    Size:
    325 amino acids
    Molecular mass:
    35119 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD34088.1; Type=Frameshift; Positions=12, 266; Evidence={ECO:0000305}; Sequence=AAQ88862.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DHRS7B Gene

Proteomics data for DHRS7B Gene at MOPED

Post-translational modifications for DHRS7B Gene

  • Ubiquitination at Lys 183
  • Modification sites at PhosphoSitePlus

Other Protein References for DHRS7B Gene

Antibody Products

No data available for DME Specific Peptides for DHRS7B Gene

Domains & Families for DHRS7B Gene

Gene Families for DHRS7B Gene

Suggested Antigen Peptide Sequences for DHRS7B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IAN0

UniProtKB/Swiss-Prot:

DRS7B_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS7B: view

Function for DHRS7B Gene

Molecular function for DHRS7B Gene

UniProtKB/Swiss-Prot Function:
Putative oxidoreductase.

Enzyme Numbers (IUBMB) for DHRS7B Gene

Gene Ontology (GO) - Molecular Function for DHRS7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with DHRS7B: view
genes like me logo Genes that share phenotypes with DHRS7B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DHRS7B

miRNA for DHRS7B Gene

miRTarBase miRNAs that target DHRS7B

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHRS7B Gene

Localization for DHRS7B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHRS7B Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHRS7B Gene COMPARTMENTS Subcellular localization image for DHRS7B gene
Compartment Confidence
endoplasmic reticulum 3
golgi apparatus 3
cytosol 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for DHRS7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DHRS7B: view

Pathways & Interactions for DHRS7B Gene

SuperPathways for DHRS7B Gene

No Data Available

Interacting Proteins for DHRS7B Gene

Gene Ontology (GO) - Biological Process for DHRS7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with DHRS7B: view

No data available for Pathways by source and SIGNOR curated interactions for DHRS7B Gene

Drugs & Compounds for DHRS7B Gene

No Compound Related Data Available

Transcripts for DHRS7B Gene

Unigene Clusters for DHRS7B Gene

Dehydrogenase/reductase (SDR family) member 7B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS7B Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - - - - -
SP2: - - - - - - -
SP3:
SP4: - - -
SP5: - -
SP6: - - -
SP7: -

Relevant External Links for DHRS7B Gene

GeneLoc Exon Structure for
DHRS7B
ECgene alternative splicing isoforms for
DHRS7B

Expression for DHRS7B Gene

mRNA expression in normal human tissues for DHRS7B Gene

Protein differential expression in normal tissues from HIPED for DHRS7B Gene

This gene is overexpressed in Nasal epithelium (60.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHRS7B Gene



SOURCE GeneReport for Unigene cluster for DHRS7B Gene Hs.386989

genes like me logo Genes that share expression patterns with DHRS7B: view

Protein tissue co-expression partners for DHRS7B Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DHRS7B Gene

Orthologs for DHRS7B Gene

This gene was present in the common ancestor of animals.

Orthologs for DHRS7B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DHRS7B 35
  • 81.74 (n)
  • 81.23 (a)
DHRS7B 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DHRS7B 35
  • 86.52 (n)
  • 87.35 (a)
DHRS7B 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dhrs7b 35
  • 82.46 (n)
  • 78.02 (a)
Dhrs7b 16
Dhrs7b 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DHRS7B 35
  • 99.49 (n)
  • 99.08 (a)
DHRS7B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dhrs7b 35
  • 81.23 (n)
  • 77.54 (a)
oppossum
(Monodelphis domestica)
Mammalia DHRS7B 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DHRS7B 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves DHRS7B 35
  • 71.3 (n)
  • 71.6 (a)
DHRS7B 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHRS7B 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhrs7b 35
  • 66.24 (n)
  • 67.96 (a)
Str.1806 35
zebrafish
(Danio rerio)
Actinopterygii dhrs7b 35
  • 61.51 (n)
  • 57.57 (a)
Dr.14424 35
dhrs7b 36
  • 57 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5249 35
African malaria mosquito
(Anopheles gambiae)
Insecta DHRS7_ANOGA 35
  • 52.4 (n)
  • 49.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7601 35
  • 51.55 (n)
  • 46.03 (a)
CG7601 36
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dhs-30 35
  • 49.23 (n)
  • 41.34 (a)
C33E10.10 36
  • 32 (a)
ManyToMany
dhs-30 36
  • 37 (a)
ManyToMany
T25G12.13 36
  • 35 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for DHRS7B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHRS7B Gene

ENSEMBL:
Gene Tree for DHRS7B (if available)
TreeFam:
Gene Tree for DHRS7B (if available)

Paralogs for DHRS7B Gene

Paralogs for DHRS7B Gene

(3) SIMAP similar genes for DHRS7B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DHRS7B: view

Variants for DHRS7B Gene

Sequence variations from dbSNP and Humsavar for DHRS7B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1448 -- 21,185,027(-) AATCA(A/G)TTATG intron-variant
rs899331 -- 21,167,211(+) CTGCA(C/T)AAATG intron-variant
rs899332 -- 21,169,029(+) TCATC(C/T)TGCTC intron-variant
rs899333 -- 21,169,050(+) GTGAA(A/G)ACGGG intron-variant
rs999187 -- 21,166,999(+) TTTTT(A/G)TTAAC intron-variant

Variation tolerance for DHRS7B Gene

Residual Variation Intolerance Score: 46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHRS7B Gene

HapMap Linkage Disequilibrium report
DHRS7B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DHRS7B Gene

Disorders for DHRS7B Gene

Relevant External Links for DHRS7B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHRS7B

No disorders were found for DHRS7B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHRS7B Gene

Publications for DHRS7B Gene

  1. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3 4 67
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. (PMID: 24797263) Tong J. … Moran M.F. (Mol. Cell Proteomics 2014) 3

Products for DHRS7B Gene

Sources for DHRS7B Gene

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