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Aliases for DHRS7 Gene

Aliases for DHRS7 Gene

  • Dehydrogenase/Reductase (SDR Family) Member 7 2 3
  • Retinal Short-Chain Dehydrogenase/Reductase 4 2 3 4
  • RetSDR4 3 4 6
  • Short Chain Dehydrogenase/Reductase Family 34C Member 1 3 4
  • SDR34C1 3 4
  • Short Chain Dehydrogenase/Reductase Family 34C, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 34C 2
  • Dehydrogenase/Reductase SDR Family Member 7 3
  • EC 1.1.-.- 4
  • Member 1 2
  • RetDSR4 3
  • CGI-86 3
  • DHRS7A 4

External Ids for DHRS7 Gene

Summaries for DHRS7 Gene

Entrez Gene Summary for DHRS7 Gene

  • Short-chain dehydrogenases/reductases (SDRs), such as DHRS7, catalyze the oxidation/reduction of a wide range of substrates, including retinoids and steroids (Haeseleer and Palczewski, 2000 [PubMed 10800688]).[supplied by OMIM, Jun 2009]

GeneCards Summary for DHRS7 Gene

DHRS7 (Dehydrogenase/Reductase (SDR Family) Member 7) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity. An important paralog of this gene is HSD11B2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS7 Gene

Genomics for DHRS7 Gene

Genomic Location for DHRS7 Gene

Start:
60,144,120 bp from pter
End:
60,169,856 bp from pter
Size:
25,737 bases
Orientation:
Minus strand

Genomic View for DHRS7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHRS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS7 Gene

Regulatory Elements for DHRS7 Gene

Proteins for DHRS7 Gene

  • Protein details for DHRS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y394-DHRS7_HUMAN
    Recommended name:
    Dehydrogenase/reductase SDR family member 7
    Protein Accession:
    Q9Y394
    Secondary Accessions:
    • B2R896
    • Q9UKU2

    Protein attributes for DHRS7 Gene

    Size:
    339 amino acids
    Molecular mass:
    38299 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DHRS7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHRS7 Gene

Proteomics data for DHRS7 Gene at MOPED

Post-translational modifications for DHRS7 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys123, Lys321, and Lys332

No data available for DME Specific Peptides for DHRS7 Gene

Domains for DHRS7 Gene

Gene Families for DHRS7 Gene

HGNC:
  • SDRC3 :Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 3

UniProtKB/Swiss-Prot:

DHRS7_HUMAN
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.:
    • Q9Y394
genes like me logo Genes that share domains with DHRS7: view

Function for DHRS7 Gene

Enzyme Numbers (IUBMB) for DHRS7 Gene

Gene Ontology (GO) - Molecular Function for DHRS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with DHRS7: view

Phenotypes for DHRS7 Gene

genes like me logo Genes that share phenotypes with DHRS7: view

No data available for Molecular function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DHRS7 Gene

Localization for DHRS7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHRS7 Gene COMPARTMENTS Subcellular localization image for DHRS7 gene
Compartment Confidence
endoplasmic reticulum 3
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DHRS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DHRS7: view

Pathways for DHRS7 Gene

SuperPathways for DHRS7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHRS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DHRS7: view

No data available for Pathways by source for DHRS7 Gene

Transcripts for DHRS7 Gene

Unigene Clusters for DHRS7 Gene

Dehydrogenase/reductase (SDR family) member 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS7 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9
SP1: - - - - -
SP2: - -
SP3: - -
SP4:
SP5:
SP6:

Relevant External Links for DHRS7 Gene

GeneLoc Exon Structure for
DHRS7
ECgene alternative splicing isoforms for
DHRS7

Expression for DHRS7 Gene

mRNA expression in normal human tissues for DHRS7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DHRS7 Gene

This gene is overexpressed in Muscle - Skeletal (8.3) and Whole Blood (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHRS7 Gene

SOURCE GeneReport for Unigene cluster for DHRS7 Gene Hs.59719

genes like me logo Genes that share expressions with DHRS7: view

Orthologs for DHRS7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHRS7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHRS7 36
  • 99.61 (n)
  • 99.71 (a)
DHRS7 37
  • 83 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DHRS7 36
  • 87.22 (n)
  • 84.96 (a)
DHRS7 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DHRS7 36
  • 87.66 (n)
  • 85.13 (a)
DHRS7 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dhrs7 36
  • 78.63 (n)
  • 79.17 (a)
Dhrs7 16
Dhrs7 37
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DHRS7 37
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1565002 36
  • 79.06 (n)
  • 77.56 (a)
chicken
(Gallus gallus)
Aves DHRS7 36
  • 71.24 (n)
  • 69.28 (a)
DHRS7 37
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHRS7 37
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.18967 36
tropical clawed frog
(Silurana tropicalis)
Amphibia dhrs7 36
  • 65.35 (n)
  • 67.43 (a)
Str.7096 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2112 36
zebrafish
(Danio rerio)
Actinopterygii dhrs7 36
  • 61.29 (n)
  • 61.94 (a)
dhrs7 37
  • 59 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010696 36
  • 46.54 (n)
  • 38.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31937 36
  • 47.23 (n)
  • 36.75 (a)
CG31937 37
  • 34 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G03330 36
  • 50.12 (n)
  • 42.03 (a)
rice
(Oryza sativa)
Liliopsida Os11g0265400 36
  • 45.73 (n)
  • 36.82 (a)
Species with no ortholog for DHRS7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DHRS7 Gene

ENSEMBL:
Gene Tree for DHRS7 (if available)
TreeFam:
Gene Tree for DHRS7 (if available)

Paralogs for DHRS7 Gene

Selected SIMAP similar genes for DHRS7 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DHRS7: view

Variants for DHRS7 Gene

Sequence variations from dbSNP and Humsavar for DHRS7 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs368229 -- 60,146,048(-) TCCCA(C/T)TATTT intron-variant
rs370105 -- 60,149,004(-) TAGAG(C/T)GAGAC intron-variant
rs371120 -- 60,148,907(-) CATAT(A/C)TTTTG intron-variant
rs373786 -- 60,145,184(-) ATCTA(A/G)AATTT intron-variant
rs376663 -- 60,150,615(-) ATGAA(C/G)CTAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHRS7 Gene

Variant ID Type Subtype PubMed ID
esv2671510 CNV Deletion 23128226
nsv1293 CNV Insertion 18451855

Relevant External Links for DHRS7 Gene

HapMap Linkage Disequilibrium report
DHRS7

Disorders for DHRS7 Gene

No disorders were found for DHRS7 Gene.

No data available for UniProtKB/Swiss-Prot for DHRS7 Gene

Publications for DHRS7 Gene

  1. Short-chain dehydrogenases/reductases in retina. (PMID: 10800688) Haeseleer F. … Palczewski K. (Methods Enzymol. 2000) 2 3 4
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for DHRS7 Gene

Sources for DHRS7 Gene

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