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Aliases for DHRS4L2 Gene

Aliases for DHRS4L2 Gene

  • Dehydrogenase/Reductase (SDR Family) Member 4 Like 2 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 25C Member 3 3 4
  • SDR25C3 3 4
  • NADP(H)-Dependent Retinol Dehydrogenase/Reductase Short Isoform-Like Protein 3
  • Short Chain Dehydrogenase/Reductase Family 25C, Member 3 3
  • Dehydrogenase/Reductase (SDR Family) Member 4 Like 2A3 3
  • Short Chain Dehydrogenase/Reductase Family 25C 2
  • EC 63
  • EC 1.1.-.- 4
  • Member 3 2
  • EC 1.1.1 63

External Ids for DHRS4L2 Gene

Previous GeneCards Identifiers for DHRS4L2 Gene

  • GC14U900021
  • GC14P022448
  • GC14P023527
  • GC14P024458
  • GC14P004556
  • GC14P024444

Summaries for DHRS4L2 Gene

Entrez Gene Summary for DHRS4L2 Gene

  • This gene encodes a member of the short chain dehydrogenase reductase family. The encoded protein may be an NADPH dependent retinol oxidoreductase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]

GeneCards Summary for DHRS4L2 Gene

DHRS4L2 (Dehydrogenase/Reductase (SDR Family) Member 4 Like 2) is a Protein Coding gene. Among its related pathways are Metabolism of xenobiotics by cytochrome P450 and Signaling by Retinoic Acid. GO annotations related to this gene include oxidoreductase activity. An important paralog of this gene is DECR2.

UniProtKB/Swiss-Prot for DHRS4L2 Gene

  • Probable oxidoreductase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS4L2 Gene

Genomics for DHRS4L2 Gene

Regulatory Elements for DHRS4L2 Gene

Enhancers for DHRS4L2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DHRS4L2 on UCSC Golden Path with GeneCards custom track

Promoters for DHRS4L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DHRS4L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DHRS4L2 Gene

23,969,874 bp from pter
24,006,408 bp from pter
36,535 bases
Plus strand

Genomic View for DHRS4L2 Gene

Genes around DHRS4L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHRS4L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHRS4L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS4L2 Gene

Proteins for DHRS4L2 Gene

  • Protein details for DHRS4L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dehydrogenase/reductase SDR family member 4-like 2
    Protein Accession:
    Secondary Accessions:
    • Q3YLD4

    Protein attributes for DHRS4L2 Gene

    230 amino acids
    Molecular mass:
    24586 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DHRS4L2 Gene


neXtProt entry for DHRS4L2 Gene

Proteomics data for DHRS4L2 Gene at MOPED

Selected DME Specific Peptides for DHRS4L2 Gene

Post-translational modifications for DHRS4L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DHRS4L2 Gene

Gene Families for DHRS4L2 Gene

Protein Domains for DHRS4L2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS4L2: view

Function for DHRS4L2 Gene

Molecular function for DHRS4L2 Gene

UniProtKB/Swiss-Prot Function:
Probable oxidoreductase.

Enzyme Numbers (IUBMB) for DHRS4L2 Gene

genes like me logo Genes that share phenotypes with DHRS4L2: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DHRS4L2 Gene

Localization for DHRS4L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHRS4L2 Gene


Subcellular locations from

Jensen Localization Image for DHRS4L2 Gene COMPARTMENTS Subcellular localization image for DHRS4L2 gene
Compartment Confidence
mitochondrion 4
extracellular 3
cytosol 2
nucleus 2
peroxisome 2

No data available for Gene Ontology (GO) - Cellular Components for DHRS4L2 Gene

Pathways & Interactions for DHRS4L2 Gene

genes like me logo Genes that share pathways with DHRS4L2: view

Pathways by source for DHRS4L2 Gene

2 KEGG pathways for DHRS4L2 Gene

Interacting Proteins for DHRS4L2 Gene

Gene Ontology (GO) - Biological Process for DHRS4L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with DHRS4L2: view

No data available for SIGNOR curated interactions for DHRS4L2 Gene

Drugs & Compounds for DHRS4L2 Gene

(1) Drugs for DHRS4L2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Matairesinol Experimental Pharma Target 0
genes like me logo Genes that share compounds with DHRS4L2: view

Transcripts for DHRS4L2 Gene

Unigene Clusters for DHRS4L2 Gene

Dehydrogenase/reductase (SDR family) member 4 like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS4L2 Gene

No ASD Table

Relevant External Links for DHRS4L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHRS4L2 Gene

mRNA expression in normal human tissues for DHRS4L2 Gene

Protein differential expression in normal tissues from HIPED for DHRS4L2 Gene

This gene is overexpressed in Heart (61.4) and Skin (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DHRS4L2 Gene

SOURCE GeneReport for Unigene cluster for DHRS4L2 Gene Hs.743442

genes like me logo Genes that share expression patterns with DHRS4L2: view

Protein tissue co-expression partners for DHRS4L2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DHRS4L2 Gene

Orthologs for DHRS4L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DHRS4L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DHRS4 36
  • 63 (a)
(Canis familiaris)
Mammalia DHRS4 36
  • 63 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 44 (a)
(Mus musculus)
Mammalia Dhrs4 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 25 (a)
-- 36
  • 18 (a)
(Pan troglodytes)
Mammalia DHRS4L1 36
  • 60 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
(Danio rerio)
Actinopterygii DHRS2 36
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10672 36
  • 32 (a)
(Caenorhabditis elegans)
Secernentea dhs-13 36
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
-- 36
  • 21 (a)
Species with no ortholog for DHRS4L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DHRS4L2 Gene

Gene Tree for DHRS4L2 (if available)
Gene Tree for DHRS4L2 (if available)

Paralogs for DHRS4L2 Gene

Paralogs for DHRS4L2 Gene Pseudogenes for DHRS4L2 Gene

genes like me logo Genes that share paralogs with DHRS4L2: view

Variants for DHRS4L2 Gene

Sequence variations from dbSNP and Humsavar for DHRS4L2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs2273947 - 23,989,002(+) TGCGG(A/T)TGGCC intron-variant, reference, missense
rs7140627 -- 23,998,556(+) gctgc(C/T)tcatc intron-variant
rs2759420 -- 23,977,427(-) TGGTA(A/C)CACAC intron-variant
rs2759423 -- 23,973,690(-) tcttc(C/T)tgttg intron-variant
rs2759424 -- 23,973,674(-) atccc(C/T)ttacc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHRS4L2 Gene

Variant ID Type Subtype PubMed ID
nsv1217 CNV Loss 18451855
nsv89 CNV Loss 15895083
nsv1218 CNV Insertion 18451855
nsv9124 CNV Loss 18304495
esv2748487 CNV Deletion 23290073
nsv509528 CNV Insertion 20534489
nsv511030 OTHER Complex 20534489
esv2421714 CNV Deletion 20811451
dgv1854n71 CNV Loss 21882294
nsv901497 CNV Gain 21882294
esv33403 CNV Loss 17666407
nsv436726 CNV Insertion 17901297
dgv20n47 CNV Gain 21111241
nsv512352 CNV Loss 21212237
nsv513749 CNV Insertion 21212237
esv28806 CNV Loss 19812545
nsv436830 CNV Insertion 17901297
nsv826901 CNV Loss 20364138
nsv482169 CNV Gain 20164927
esv2748488 CNV Deletion 23290073
nsv510630 CNV Loss 20534489
nsv91 CNV Loss 15895083
esv988372 CNV Deletion 20482838
esv1586699 CNV Deletion 17803354
nsv84893 CNV Loss 16902084

Variation tolerance for DHRS4L2 Gene

Residual Variation Intolerance Score: 95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.47; 94.33% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DHRS4L2 Gene

Disorders for DHRS4L2 Gene

Relevant External Links for DHRS4L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DHRS4L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHRS4L2 Gene

Publications for DHRS4L2 Gene

  1. Non-EST based prediction of exon skipping and intron retention events using Pfam information. (PMID: 16204458) Hiller M. … Backofen R. (Nucleic Acids Res. 2005) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes. (PMID: 23036705) Gabrielli F. … Tofanelli S. (Gene 2012) 3
  4. Bioinformatic analysis of the human DHRS4 gene cluster and a proposed mechanism for its transcriptional regulation. (PMID: 20525226) Su Z.J. … Huang D.Y. (BMC Mol. Biol. 2010) 3
  5. Alternative transcription initiation and splicing variants of the DHRS4 gene cluster. (PMID: 18754758) Zhang Q. … Huang D. (Biosci. Rep. 2009) 3

Products for DHRS4L2 Gene

Sources for DHRS4L2 Gene