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Aliases for DHRS4L2 Gene

Aliases for DHRS4L2 Gene

  • Dehydrogenase/Reductase (SDR Family) Member 4 Like 2 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 25C Member 3 3 4
  • SDR25C3 3 4
  • NADP(H)-Dependent Retinol Dehydrogenase/Reductase Short Isoform-Like Protein 3
  • Short Chain Dehydrogenase/Reductase Family 25C, Member 3 3
  • Dehydrogenase/Reductase (SDR Family) Member 4 Like 2A3 3
  • Short Chain Dehydrogenase/Reductase Family 25C 2
  • EC 1.1.1.184 63
  • EC 1.1.-.- 4
  • Member 3 2
  • EC 1.1.1 63

External Ids for DHRS4L2 Gene

Previous GeneCards Identifiers for DHRS4L2 Gene

  • GC14U900021
  • GC14P022448
  • GC14P023527
  • GC14P024458
  • GC14P004556
  • GC14P024444

Summaries for DHRS4L2 Gene

Entrez Gene Summary for DHRS4L2 Gene

  • This gene encodes a member of the short chain dehydrogenase reductase family. The encoded protein may be an NADPH dependent retinol oxidoreductase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]

GeneCards Summary for DHRS4L2 Gene

DHRS4L2 (Dehydrogenase/Reductase (SDR Family) Member 4 Like 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include oxidoreductase activity. An important paralog of this gene is DECR2.

UniProtKB/Swiss-Prot for DHRS4L2 Gene

  • Probable oxidoreductase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS4L2 Gene

Genomics for DHRS4L2 Gene

Regulatory Elements for DHRS4L2 Gene

Promoters for DHRS4L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DHRS4L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DHRS4L2 Gene

Chromosome:
14
Start:
23,969,874 bp from pter
End:
24,006,408 bp from pter
Size:
36,535 bases
Orientation:
Plus strand

Genomic View for DHRS4L2 Gene

Genes around DHRS4L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHRS4L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHRS4L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS4L2 Gene

Proteins for DHRS4L2 Gene

  • Protein details for DHRS4L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PKH6-DR4L2_HUMAN
    Recommended name:
    Dehydrogenase/reductase SDR family member 4-like 2
    Protein Accession:
    Q6PKH6
    Secondary Accessions:
    • Q3YLD4

    Protein attributes for DHRS4L2 Gene

    Size:
    230 amino acids
    Molecular mass:
    24586 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DHRS4L2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHRS4L2 Gene

Proteomics data for DHRS4L2 Gene at MOPED

Selected DME Specific Peptides for DHRS4L2 Gene

Post-translational modifications for DHRS4L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DHRS4L2 Gene

Gene Families for DHRS4L2 Gene

Protein Domains for DHRS4L2 Gene

Graphical View of Domain Structure for InterPro Entry

Q6PKH6

UniProtKB/Swiss-Prot:

DR4L2_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS4L2: view

Function for DHRS4L2 Gene

Molecular function for DHRS4L2 Gene

UniProtKB/Swiss-Prot Function:
Probable oxidoreductase.

Enzyme Numbers (IUBMB) for DHRS4L2 Gene

genes like me logo Genes that share phenotypes with DHRS4L2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DHRS4L2 Gene

Localization for DHRS4L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHRS4L2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHRS4L2 Gene COMPARTMENTS Subcellular localization image for DHRS4L2 gene
Compartment Confidence
mitochondrion 4
extracellular 3
cytosol 2
nucleus 2
peroxisome 2

No data available for Gene Ontology (GO) - Cellular Components for DHRS4L2 Gene

Pathways & Interactions for DHRS4L2 Gene

genes like me logo Genes that share pathways with DHRS4L2: view

Pathways by source for DHRS4L2 Gene

2 KEGG pathways for DHRS4L2 Gene

Interacting Proteins for DHRS4L2 Gene

Gene Ontology (GO) - Biological Process for DHRS4L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with DHRS4L2: view

No data available for SIGNOR curated interactions for DHRS4L2 Gene

Drugs & Compounds for DHRS4L2 Gene

(1) Drugs for DHRS4L2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Matairesinol Experimental Pharma Target 0
genes like me logo Genes that share compounds with DHRS4L2: view

Transcripts for DHRS4L2 Gene

Unigene Clusters for DHRS4L2 Gene

Dehydrogenase/reductase (SDR family) member 4 like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS4L2 Gene

No ASD Table

Relevant External Links for DHRS4L2 Gene

GeneLoc Exon Structure for
DHRS4L2
ECgene alternative splicing isoforms for
DHRS4L2

Expression for DHRS4L2 Gene

mRNA expression in normal human tissues for DHRS4L2 Gene

Protein differential expression in normal tissues from HIPED for DHRS4L2 Gene

This gene is overexpressed in Heart (61.4) and Skin (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DHRS4L2 Gene



SOURCE GeneReport for Unigene cluster for DHRS4L2 Gene Hs.743442

genes like me logo Genes that share expression patterns with DHRS4L2: view

Protein tissue co-expression partners for DHRS4L2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DHRS4L2 Gene

Orthologs for DHRS4L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DHRS4L2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DHRS4 36
  • 63 (a)
OneToMany
dog
(Canis familiaris)
Mammalia DHRS4 36
  • 63 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 44 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Dhrs4 36
  • 61 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 25 (a)
ManyToMany
-- 36
  • 18 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia DHRS4L1 36
  • 60 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii DHRS2 36
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10672 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dhs-13 36
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
ManyToMany
-- 36
  • 21 (a)
ManyToMany
Species with no ortholog for DHRS4L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DHRS4L2 Gene

ENSEMBL:
Gene Tree for DHRS4L2 (if available)
TreeFam:
Gene Tree for DHRS4L2 (if available)

Paralogs for DHRS4L2 Gene

Paralogs for DHRS4L2 Gene

Pseudogenes.org Pseudogenes for DHRS4L2 Gene

genes like me logo Genes that share paralogs with DHRS4L2: view

Variants for DHRS4L2 Gene

Sequence variations from dbSNP and Humsavar for DHRS4L2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs2273947 - 23,989,002(+) TGCGG(A/T)TGGCC intron-variant, reference, missense
rs1028677 -- 23,984,249(+) GGGAA(C/G)AGTTA intron-variant
rs1811890 -- 24,000,929(+) AGAAA(C/G/T)GAGGG intron-variant, reference, stop-gained
rs1885803 -- 23,991,080(+) GCTCA(A/C/G)GGCAC intron-variant
rs1885804 -- 23,991,085(+) GGGCA(C/T)ACACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHRS4L2 Gene

Variant ID Type Subtype PubMed ID
nsv1217 CNV Loss 18451855
nsv89 CNV Loss 15895083
nsv1218 CNV Insertion 18451855
nsv9124 CNV Loss 18304495
esv2748487 CNV Deletion 23290073
nsv509528 CNV Insertion 20534489
nsv511030 OTHER Complex 20534489
esv2421714 CNV Deletion 20811451
dgv1854n71 CNV Loss 21882294
nsv901497 CNV Gain 21882294
esv33403 CNV Loss 17666407
nsv436726 CNV Insertion 17901297
dgv20n47 CNV Gain 21111241
nsv512352 CNV Loss 21212237
nsv513749 CNV Insertion 21212237
esv28806 CNV Loss 19812545
nsv436830 CNV Insertion 17901297
nsv826901 CNV Loss 20364138
nsv482169 CNV Gain 20164927
esv2748488 CNV Deletion 23290073
nsv510630 CNV Loss 20534489
nsv91 CNV Loss 15895083
esv988372 CNV Deletion 20482838
esv1586699 CNV Deletion 17803354
nsv84893 CNV Loss 16902084

Variation tolerance for DHRS4L2 Gene

Residual Variation Intolerance Score: 95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.47; 94.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHRS4L2 Gene

HapMap Linkage Disequilibrium report
DHRS4L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHRS4L2 Gene

Disorders for DHRS4L2 Gene

Relevant External Links for DHRS4L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHRS4L2

No disorders were found for DHRS4L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHRS4L2 Gene

Publications for DHRS4L2 Gene

  1. Non-EST based prediction of exon skipping and intron retention events using Pfam information. (PMID: 16204458) Hiller M. … Backofen R. (Nucleic Acids Res. 2005) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes. (PMID: 23036705) Gabrielli F. … Tofanelli S. (Gene 2012) 3
  4. Bioinformatic analysis of the human DHRS4 gene cluster and a proposed mechanism for its transcriptional regulation. (PMID: 20525226) Su Z.J. … Huang D.Y. (BMC Mol. Biol. 2010) 3
  5. Alternative transcription initiation and splicing variants of the DHRS4 gene cluster. (PMID: 18754758) Zhang Q. … Huang D. (Biosci. Rep. 2009) 3

Products for DHRS4L2 Gene

Sources for DHRS4L2 Gene

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