Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DHRS4L2 Gene

protein-coding   GIFtS: 45
GCID: GC14P024444

Dehydrogenase/Reductase (SDR Family) Member 4 Like 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Dehydrogenase/Reductase (SDR Family) Member 4 Like 21 2     NADP(H)-Dependent Retinol Dehydrogenase/Reductase Short Isoform-Like
Protein2
Member 31     Short Chain Dehydrogenase/Reductase Family 25C, Member 32
Short Chain Dehydrogenase/Reductase Family 25C1     EC 1.1.-.-3
SDR25C32     EC 1.1.18
Dehydrogenase/Reductase (SDR Family) Member 4 Like 2A32     EC 1.1.1.1848
Dehydrogenase/Reductase SDR Family Member 4-Like 22     

External Ids:    HGNC: 197311   Entrez Gene: 3177492   Ensembl: ENSG000001876307   OMIM: 6151965   UniProtKB: Q6PKH63   

Export aliases for DHRS4L2 gene to outside databases

Previous GC identifers: GC14U900021 GC14P022448 GC14P023527 GC14P024458 GC14P004556


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DHRS4L2 Gene:
This gene encodes a member of the short chain dehydrogenase reductase family. The encoded protein may be an NADPH
dependent retinol oxidoreductase. Alternate splicing results in multiple transcript variants. (provided by
RefSeq, Aug 2010)

GeneCards Summary for DHRS4L2 Gene:
DHRS4L2 (dehydrogenase/reductase (SDR family) member 4 like 2) is a protein-coding gene. Diseases associated with DHRS4L2 include tuberculosis, and cervicitis. GO annotations related to this gene include oxidoreductase activity. An important paralog of this gene is HPGD.

UniProtKB/Swiss-Prot: DR4L2_HUMAN, Q6PKH6
Function: Probable oxidoreductase (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the DHRS4L2 gene promoter:
         TBP   Sp1   CUTL1   POU6F1 (c2)   C/EBPalpha   GATA-2   GATA-1   TFIID   Cart-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DHRS4L2 promoter sequence
   Search Chromatin IP Primers for DHRS4L2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DHRS4L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

DHRS4L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHRS4L2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P024444:  view genomic region     (about GC identifiers)

Start:
24,439,083 bp from pter      End:
24,475,617 bp from pter
Size:
36,535 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DR4L2_HUMAN, Q6PKH6 (See protein sequence)
Recommended Name: Dehydrogenase/reductase SDR family member 4-like 2 precursor  
Size: 230 amino acids; 24586 Da
Secondary accessions: Q3YLD4
Alternative splicing: 2 isoforms:  Q6PKH6-1   Q6PKH6-2   

Explore the universe of human proteins at neXtProt for DHRS4L2: NX_Q6PKH6

Explore proteomics data for DHRS4L2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn181
  • Selected DME Specific Peptides for DHRS4L2 (Q6PKH6) (see all 5)
     TEEVWDK  NKVALVT  SSRKQQNVD  VCHVGKAEDRE 


    See DHRS4L2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001180564.1  NP_001180565.1  NP_001180566.1  NP_932349.2  

    ENSEMBL proteins: 
     ENSP00000380261   ENSP00000453889   ENSP00000334801   ENSP00000453845   ENSP00000439942  
     ENSP00000453173   ENSP00000452875   ENSP00000437883   ENSP00000372203   ENSP00000441433  
     ENSP00000441095  

    DHRS4L2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DHRS4L2
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DHRS4L2
    GenScript Custom Purified and Recombinant Proteins Services for DHRS4L2
    Novus Biologicals DHRS4L2 Protein
    Novus Biologicals DHRS4L2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DHRS4L2

    DHRS4L2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DHRS4L2
    Novus Biologicals DHRS4L2 Antibody
    Search for Antibodies for DHRS4L2 at Abcam
    Cloud-Clone Corp. Antibodies for DHRS4L2
    Search ThermoFisher Antibodies for DHRS4L2
    LSBio Antibodies in human, mouse, rat for DHRS4L2

    DHRS4L2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DHRS4L2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DHRS4L2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DHRS4L2
    Cloud-Clone Corp. CLIAs for DHRS4L2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SDRC1: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 1

    4 InterPro protein domains:
     IPR020904 Sc_DH/Rdtase_CS
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q6PKH6

    ProtoNet protein and cluster: Q6PKH6

    1 Blocks protein domain: IPB002198 Short-chain dehydrogenase/reductase SDR

    UniProtKB/Swiss-Prot: DR4L2_HUMAN, Q6PKH6
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    DHRS4L2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DR4L2_HUMAN, Q6PKH6
    Function: Probable oxidoreductase (By similarity)

         Enzyme Numbers (IUBMB): EC 1.1.-.-1 EC 1.1.12 EC 1.1.1.1842

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016491oxidoreductase activity IEA--
         
    DHRS4L2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DHRS4L2:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DHRS4L2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DHRS4L2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DHRS4L2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DHRS4L2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat DHRS4L2 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate DHRS4L2:
    hsa-miR-214 hsa-miR-761 hsa-miR-3153 hsa-miR-4257 hsa-miR-3171
    SwitchGear 3'UTR luciferase reporter plasmidDHRS4L2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DHRS4L2
    Predesigned siRNA for gene silencing in human, mouse, rat DHRS4L2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DHRS4L2

    Clone
    Products:
         
    OriGene clones in human, mouse for DHRS4L2 (see all 16)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): DHRS4L2 (NM_198083)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHRS4L2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHRS4L2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DHRS4L2
    Browse ESI BIO Cell Lines and PureStem Progenitors for DHRS4L2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHRS4L2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DR4L2_HUMAN, Q6PKH6: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    mitochondrion3
    cytosol2
    peroxisome2
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    DHRS4L2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for DHRS4L2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.38
    2Chemical carcinogenesis
    Retinol metabolism0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Kegg Pathways  (Kegg details for DHRS4L2):
        Retinol metabolism
    Metabolic pathways


    DHRS4L2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DHRS4L2
    Interactions:

        Search GeneGlobe Interaction Network for DHRS4L2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for DHRS4L2 (ENSP000003348014) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESPNENSP000003670594STRING: ENSP00000367059
    ESPNLENSP000003391154STRING: ENSP00000339115
    TREHENSP000002640294STRING: ENSP00000264029
    PEBP1ENSP000002613134STRING: ENSP00000261313
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----

    DHRS4L2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DHRS4L2 (DR4L2)

    2 DrugBank Compounds for DHRS4L2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Matairesinol(-)-Matairesinol (see all 5)580-72-3target--10592235
    Nicotinamide-Adenine-Dinucleotide-- 53-84-9target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DHRS4L2 gene (4 alternative transcripts): 
    NM_001193635.1  NM_001193636.1  NM_001193637.1  NM_198083.3  

    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397071(uc001wle.4) ENST00000559411(uc021rrf.1) ENST00000335125(uc001wld.4 uc021rre.1 uc001wli.4 uc010alb.3)
    ENST00000558753 ENST00000537912(uc010tnt.2) ENST00000559387 ENST00000557812
    ENST00000560276 ENST00000545240 ENST00000382755 ENST00000543805(uc001wlf.3 uc021rra.1)
    ENST00000534993(uc021rrb.1 uc021rrc.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DHRS4L2 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate DHRS4L2:
    hsa-miR-214 hsa-miR-761 hsa-miR-3153 hsa-miR-4257 hsa-miR-3171
    SwitchGear 3'UTR luciferase reporter plasmidDHRS4L2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DHRS4L2
    Predesigned siRNA for gene silencing in human, mouse, rat DHRS4L2
    Clone
    Products:
         
    OriGene clones in human, mouse for DHRS4L2 (see all 16)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): DHRS4L2 (NM_198083)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHRS4L2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHRS4L2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DHRS4L2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat DHRS4L2
      QuantiTect SYBR Green Assays in human, mouse, rat DHRS4L2
      QuantiFast Probe-based Assays in human, mouse, rat DHRS4L2

    Selected AceView cDNA sequences (see all 336):

    BP341298 BG696653 CB117210 CB121780 BU181392 AI537756 AI419007 AA262033 
    BX283829 BU529016 CB142429 CB128692 AI673592 CB268423 BG014141 BX474012 
    CB141508 AI635433 BE741442 BE745939 BU846322 AA977092 BQ438157 BG696620 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DHRS4L2 expression in normal human tissues (normalized intensities)      DHRS4L2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DHRS4L2 Expression
    About this image


    DHRS4L2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
    DHRS4L2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DHRS4L2 Protein Expression
        Custom PCR Arrays for DHRS4L2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for DHRS4L2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat DHRS4L2
    QuantiTect SYBR Green Assays in human, mouse, rat DHRS4L2
    QuantiFast Probe-based Assays in human, mouse, rat DHRS4L2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHRS4L2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for DHRS4L2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    49(a)
    1 → many
    GL343877.1(71502-81133)
    zebrafish
    (Danio rerio)
    Actinopterygii DHRS26
    dehydrogenase/reductase (SDR family) member 2
    46(a)
    1 → many
    7(25206555-25214121) ENSDARG00000021135
    fruit fly
    (Drosophila melanogaster)
    Insecta CG106726
    --
    32(a)
    1 → many
    3L(5133540-5134746)
    worm
    (Caenorhabditis elegans)
    Secernentea dhs-136
    Protein DHS-13 (dhs-13) mRNA, complete cds
    39(a)
    1 → many
    V(1765319-1771727) WBGene00000976
            Species with no ortholog for DHRS4L2

    ENSEMBL Gene Tree for DHRS4L2 (if available)
    TreeFam Gene Tree for DHRS4L2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DHRS4L2 gene
    HPGD2  DCXR2  DECR22  CBR42  PECR2  HSD17B142  DHRS22  HSD17B102  
    DHRS42  BDH22  HSD17B82  DECR12  
    10 SIMAP similar genes for DHRS4L2 using alignment to 12 protein entries:     DR4L2_HUMAN (see all proteins):
    DHRS4    DHRSX    DHRS2    DHRS4L1    DCXR    RDH8
    KDSR    HSD17B4    DHRS7    DHRS11

    DHRS4L2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for DHRS4L2
    PGOHUM00000261844 PGOHUM00000262044


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DHRS4L2 (see all 1235)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1932145681,2
    C--4558919(+) GTGAGC/TCCAGG 1 -- int10--------
    rs1855243801,2
    --4558930(+) GGACCA/GGCGCT 1 -- int10--------
    rs1903449391,2
    --4558945(+) ATACCA/GAGGAC 1 -- int10--------
    rs49828421,2
    C,A,H--4558951(+) aggacT/Ctgcac 1 -- int13Minor allele frequency- C:0.20NA CSA 5
    rs49828431,2
    C,H--4558958(+) gcaccA/Ggcacc 1 -- int12Minor allele frequency- G:0.00NA CSA 3
    rs1816743011,2
    C--4558973(+) TCTGAA/GTTCCC 1 -- int10--------
    rs1842315011,2
    --4559000(+) ATTATC/TGTCAT 1 -- int10--------
    rs1885660661,2
    --4559070(+) ACAAAC/TGTGAG 1 -- int10--------
    rs1487009131,2
    --4559075(+) CGTGAC/GCAATA 1 -- int10--------
    rs349831471,2
    C--4559087(+) ATCTA-/C/CATC
            
    ATAAT
    1 -- int10--------

    HapMap Linkage Disequilibrium report for DHRS4L2 (24439083 - 24475617 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DHRS4L2 (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1586699CNV Deletion17803354
    esv988372CNV Deletion20482838
    esv2748487CNV Deletion23290073
    esv2748488CNV Deletion23290073
    esv2421714CNV Deletion20811451
    nsv1218CNV Insertion18451855
    nsv513749CNV Insertion21212237
    nsv436726CNV Insertion17901297
    nsv509528CNV Insertion20534489
    nsv436830CNV Insertion17901297

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DHRS4L2
    DNA2.0 Custom Variant and Variant Library Synthesis for DHRS4L2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 615196    OMIM disorders: --

    2 diseases for DHRS4L2:    About MalaCards
    tuberculosis    cervicitis


    DHRS4L2 for disorders           About GeneDecksing


    Export disorders for DHRS4L2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DHRS4L2 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with DHRS4L2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Non-EST based prediction of exon skipping and intron retention events using Pfam information. (PubMed id 16204458)1, 2 Hiller M.... Backofen R. (Nucleic Acids Res. 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    4. Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes. (PubMed id 23036705)1 Gabrielli F. and Tofanelli S. (Gene 2012)
    5. Bioinformatic analysis of the human DHRS4 gene cluster and a proposed mechanism for its transcriptional regulation. (PubMed id 20525226)1 Su Z.J....Huang D.Y. (BMC Mol. Biol. 2010)
    6. Alternative transcription initiation and splicing variants of the DHRS4 gene cluster. (PubMed id 18754758)1 Zhang Q....Huang D. (Biosci. Rep. 2009)
    7. Expression of a novel alternatively spliced variant of NADP(H)- dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma. (PubMed id 17230527)1 Song X.-H.... Huang D.-Y. (Int. J. Cancer 2007)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 317749 HGNC: 19731 AceView: DHRS4andDHRS4L2andLOC400197 Ensembl:ENSG00000187630 euGenes: HUgn317749
    ECgene: DHRS4L2 Kegg: 317749 H-InvDB: DHRS4L2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DHRS4L2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DHRS4L2 gene:
    Search GeneIP for patents involving DHRS4L2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DHRS4L2  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DHRS4L2  
     OriGene qSTAR qPCR primer pairs in human, mouse for DHRS4L2   OriGene Purified Protein for DHRS4L2  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DHRS4L2   OriGene Custom Protein Services for DHRS4L2  

     
     
     Block miRNA regulation of human, mouse, rat DHRS4L2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DHRS4L2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DHRS4L2 Predesigned siRNA for gene silencing in human, mouse, rat DHRS4L2
     QuantiFast Probe-based Assays in human, mouse, rat DHRS4L2 QuantiTect SYBR Green Assays in human, mouse, rat DHRS4L2
     Custom PCR Arrays for DHRS4L2 Search Chromatin IP Primers for DHRS4L2
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat DHRS4L2  Search GeneGlobe Interaction Network for DHRS4L2
     Regulatory tfbs in DHRS4L2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for DHRS4L2 GenScript cDNA clones with any tag delivered in your preferred vector for DHRS4L2
     GenScript Custom Assay Services for DHRS4L2 GenScript Custom overexpressing Cell Line Services for DHRS4L2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DHRS4L2 (DR4L2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DHRS4L2 antibodies
     DHRS4L2 proteins
     DHRS4L2 lysates
     Search for Antibodies for DHRS4L2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for DHRS4L2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for DHRS4L2
     Antibodies for DHRS4L2
     ELISAs for DHRS4L2
     CLIAs for DHRS4L2



     Browse ESI BIO Cell Lines and PureStem Progenitors for DHRS4L2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHRS4L2
     SwitchGear 3'UTR luciferase reporter plasmids for DHRS4L2
     SwitchGear Promoter luciferase reporter plasmids for DHRS4L2
     Search ThermoFisher Antibodies for DHRS4L2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHRS4L2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DHRS4L2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DHRS4L2
     LSBio Antibodies in human, mouse, rat for DHRS4L2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DHRS4L2 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4