DHRS4L2 Gene
protein-coding GIFtS: 46
GCID: GC14P024458
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|
dehydrogenase/reductase (SDR family) member 4 like 2
| |
Aliases
for DHRS4L2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dehydrogenase/Reductase (SDR Family) Member 4 Like 21 2 | | Short Chain Dehydrogenase/Reductase Family 25C, Member 32 | | SDR25C31 2 | | EC 1.1.-.-3 | | Dehydrogenase/Reductase (SDR Family) Member 4 Like 2A32 | | EC 1.1.18 | | Dehydrogenase/Reductase SDR Family Member 4-Like 22 | | EC 1.1.1.1848 |
Export aliases for DHRS4L2 gene to outside databasesPrevious GC identifers: GC14U900021 GC14P022448 GC14P023527 GC14P004556 |
Summaries
for DHRS4L2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DHRS4L2:
This gene encodes a member of the short chain dehydrogenase reductase family. The encoded protein may be an NADPHdependent retinol oxidoreductase. Alternate splicing results in multiple transcript variants. (provided by RefSeq, Aug2010)
UniProtKB/Swiss-Prot: DR4L2_HUMAN, Q6PKH6Function: Probable oxidoreductase (By similarity)
|
Genomic Views
for DHRS4L2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DHRS4L2 gene promoter:
TBP Sp1 CUTL1 POU6F1 (c2) C/EBPalpha GATA-2 GATA-1 TFIID Cart-1 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for DHRS4L2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHRS4L2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.2DHRS4L2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P024458: view genomic region
(about GC identifiers)
Start:
|
24,439,083 bp from pter |
End:
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24,475,617 bp from pter |
Size:
|
36,535 bases |
Orientation:
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plus strand |
|
Proteins
for DHRS4L2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DR4L2_HUMAN, Q6PKH6 (See
protein sequence)Recommended Name: Dehydrogenase/reductase SDR family member 4-like 2 precursor Size: 230 amino acids; 24586 Da
Subcellular location: Secreted (Potential)
Secondary accessions: Q3YLD4Alternative splicing: 2 isoforms: Q6PKH6-1 Q6PKH6-2 Explore the universe of human proteins at neXtProt for DHRS4L2: NX_Q6PKH6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6PKH6
4/5 DME Specific Peptides for DHRS4L2 (Q6PKH6) (see all 5)
DHRS4L2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001180564.1 NP_001180565.1 NP_001180566.1 NP_932349.2
ENSEMBL proteins: ENSP00000380261 ENSP00000453889 ENSP00000334801 ENSP00000453845 ENSP00000439942 ENSP00000453173 ENSP00000452875 ENSP00000437883 ENSP00000372203 ENSP00000441433 ENSP00000441095
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
DHRS4L2 for ontologies About GeneDecksing
DHRS4L2 Antibody Products:
Assay Products for DHRS4L2: |
Protein
Domains /
Families
for DHRS4L2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DHRS4L2 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6PKH6ProtoNet protein and cluster: Q6PKH6 1 Blocks protein family: IPB002198 Short-chain dehydrogenase/reductase SDR
UniProtKB/Swiss-Prot: DR4L2_HUMAN, Q6PKH6Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family |
Function
for DHRS4L2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DR4L2_HUMAN, Q6PKH6Function: Probable oxidoreductase (By similarity)Enzyme Numbers (IUBMB): EC 1.1.-.-1 EC 1.1.12 EC 1.1.1.1842
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DHRS4L2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DHRS4L2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for DHRS4L2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHRS4L2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHRS4L2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0016491 | oxidoreductase activity |
IEA | -- |
DHRS4L2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for DHRS4L2:
|
Pathways & Interactions
for DHRS4L2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Drug metabolism - cytochrome P450 | | | 2 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Kegg Pathways (Kegg details for DHRS4L2):
DHRS4L2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DHRS4L2
|
Drugs & Compounds
for DHRS4L2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DHRS4L2
2 DrugBank Compounds for DHRS4L2 About this table
Search CenterWatch for drugs/clinical trials and news about DHRS4L2 / DR4L2
|
Transcripts
for DHRS4L2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DHRS4L2 gene (4 alternative transcripts): NM_001193635.1 NM_001193636.1 NM_001193637.1 NM_198083.3 Unigene Cluster for DHRS4L2: Dehydrogenase/reductase (SDR family) member 4 like 2 Hs.743442 [show with all ESTs]Unigene Representative Sequence: NM_00119363612 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000397071(uc001wle.4) ENST00000559411(uc021rrf.1) ENST00000335125(uc001wld.4 uc021rre.1 uc001wli.4 uc010alb.3)
ENST00000558753 ENST00000537912(uc010tnt.2) ENST00000559387 ENST00000557812
ENST00000560276 ENST00000545240 ENST00000382755 ENST00000543805(uc001wlf.3 uc021rra.1)
ENST00000534993(uc021rrb.1 uc021rrc.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DHRS4L2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DHRS4L2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): DHRS4L2 (NM_198083) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DHRS4L2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHRS4L2 |
Additional cDNA sequence: AK301373.1 AY616183.1 AY920361.1 AY920362.1 AY943857.1 BC000663.2 BC006125.1 BC101812.1 BC101814.1 DQ088987.1 DQ088988.1 GU564234.1 21 DOTS entries: DT.447164 DT.100800245 DT.95123574 DT.120789268 DT.120789286 DT.120789294 DT.100825825 DT.120789295 DT.120789311 DT.40286930 DT.97848359 DT.120789264 DT.120789324 DT.91677685 DT.100825824 DT.102828555 DT.120789255 DT.120789282 DT.75106219 DT.91888577 DT.95104521 24/336 AceView cDNA sequences (see all 336): BU529016 CB110131 BU956321 BP355509 AI419007 BG696653 BQ030242 CB128085 BE274802 BM802689 AA738454 BF939545 AA774916 AI299098 AI202407 CA435002 AA988157 BE741442 CB128692 AA977092 AA293161 BX474012 AI537756 CB117210
GeneLoc Exon Structure
|
Expression
for DHRS4L2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DHRS4L2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See DHRS4L2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DHRS4L2
SOURCE GeneReport for Unigene cluster: Hs.743442
SABiosciences Custom PCR Arrays for DHRS4L2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DHRS4L2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat DHRS4L2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DHRS4L2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHRS4L2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHRS4L2 |
Orthologs
for DHRS4L2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DHRS4L2 gene from 7/19 species (see all 19) About this table
ENSEMBL Gene Tree for DHRS4L2 (if available)
TreeFam Gene Tree for DHRS4L2 (if available) |
Paralogs
for DHRS4L2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DHRS4L2 gene
- DECR22 DCXR2 PECR2 HSD17B142 DHRS22 BDH22 DHRS42 DECR12
10 SIMAP similar genes for DHRS4L2 using alignment to 11 protein entries: DR4L2_HUMAN (see all proteins):DHRS4 DHRSX DHRS2 DHRS4L1 DCXR RDH8
KDSR HSD17B4 DHRS7 DHRS11
DHRS4L2 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for DHRS4L2
PGOHUM00000261844 PGOHUM00000262044
|
Genomic Variants
for DHRS4L2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DHRS4L2 (24439083 - 24475617 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for DHRS4L2
13 CNVs: 5729 35243 39147 31957 35242 23483 35241 7029 35244 0437 35240 0436 87144 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DHRS4L2 |
|
Disorders
/ Diseases
for DHRS4L2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DHRS4L2 for disorders About GeneDecksing
4  diseases for DHRS4L2: About MalaCardscervicitis tuberculosis carcinoma mycobacterium tuberculosis
Export disorders for DHRS4L2 gene to outside databases
|
Publications
for DHRS4L2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DHRS4L2 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with DHRS4L2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Non-EST based prediction of exon skipping and intron retention events using Pfam information. (PubMed id 16204458)1, 2 Hiller M.... Backofen R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes. (PubMed id 23036705)1 Gabrielli F. and Tofanelli S. (2012)
- Bioinformatic analysis of the human DHRS4 gene cluste r and a proposed mechanism for its transcriptional regulation. (PubMed id 20525226)1 Su Z.J....Huang D.Y. (2010)
- Alternative transcription initiation and splicing variants of the DHRS4 gene cluster. (PubMed id 18754758)1 Zhang Q....Huang D. (2009)
- Expression of a novel alternatively spliced variant of NADP(H)- dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma. (PubMed id 17230527)1 Song X.-H.... Huang D.-Y. (2007)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- CDNA cloning of a short isoform of human liver NADP (H) -dependent retinol dehydrogenase/reductase and analysis of its characteristics. (PubMed id 15473316)1 Du J....Zhu L. (2004)
|
External Searches for DHRS4L2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DHRS4L2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DHRS4L2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DHRS4L2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DHRS4L2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DHRS4L2 gene:
Search GeneIP for patents involving DHRS4L2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DHRS4L2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DHRS4L2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DHRS4L2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHRS4L2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DHRS4L2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHRS4L2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DHRS4L2 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHRS4L2 |
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