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Aliases for DHRS4L1 Gene

Aliases for DHRS4L1 Gene

  • Dehydrogenase/Reductase (SDR Family) Member 4 Like 1 2 3
  • Short Chain Dehydrogenase/Reductase Family 25C Member 4 3 4
  • SDR25C4 3 4
  • Putative Dehydrogenase/Reductase SDR Family Member 4-Like 2 3
  • Short Chain Dehydrogenase/Reductase Family 25C, Member 4 3
  • Short Chain Dehydrogenase/Reductase Family 25C 2
  • EC 1.1.-.- 4
  • Member 4 2

External Ids for DHRS4L1 Gene

Previous GeneCards Identifiers for DHRS4L1 Gene

  • GC00U906276
  • GC14U900438
  • GC14P023577
  • GC14P024505
  • GC14P004620

Summaries for DHRS4L1 Gene

GeneCards Summary for DHRS4L1 Gene

DHRS4L1 (Dehydrogenase/Reductase (SDR Family) Member 4 Like 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include oxidoreductase activity.

UniProtKB/Swiss-Prot for DHRS4L1 Gene

  • Putative oxidoreductase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS4L1 Gene

Genomics for DHRS4L1 Gene

Regulatory Elements for DHRS4L1 Gene

Genomic Location for DHRS4L1 Gene

Chromosome:
14
Start:
24,007,009 bp from pter
End:
24,051,377 bp from pter
Size:
44,369 bases
Orientation:
Plus strand

Genomic View for DHRS4L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for DHRS4L1 Gene

Proteins for DHRS4L1 Gene

  • Protein details for DHRS4L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG22-DR4L1_HUMAN
    Recommended name:
    Putative dehydrogenase/reductase SDR family member 4-like 1
    Protein Accession:
    P0CG22

    Protein attributes for DHRS4L1 Gene

    Size:
    281 amino acids
    Molecular mass:
    30608 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DHRS4L1 Gene

Proteomics data for DHRS4L1 Gene at MOPED

Post-translational modifications for DHRS4L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHRS4L1 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for DHRS4L1 Gene

Domains & Families for DHRS4L1 Gene

Gene Families for DHRS4L1 Gene

Protein Domains for DHRS4L1 Gene

Suggested Antigen Peptide Sequences for DHRS4L1 Gene

Graphical View of Domain Structure for InterPro Entry

P0CG22

UniProtKB/Swiss-Prot:

DR4L1_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS4L1: view

Function for DHRS4L1 Gene

Molecular function for DHRS4L1 Gene

UniProtKB/Swiss-Prot Function:
Putative oxidoreductase.

Enzyme Numbers (IUBMB) for DHRS4L1 Gene

Gene Ontology (GO) - Molecular Function for DHRS4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with DHRS4L1: view

Animal Model Products

CRISPR Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DHRS4L1 Gene

Localization for DHRS4L1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for DHRS4L1 Gene

Pathways & Interactions for DHRS4L1 Gene

genes like me logo Genes that share pathways with DHRS4L1: view

Pathways by source for DHRS4L1 Gene

3 KEGG pathways for DHRS4L1 Gene

Interacting Proteins for DHRS4L1 Gene

Gene Ontology (GO) - Biological Process for DHRS4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DHRS4L1: view

No data available for SIGNOR curated interactions for DHRS4L1 Gene

Drugs & Compounds for DHRS4L1 Gene

(5) Drugs for DHRS4L1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
10-Propargyl-5,8-Dideazafolic Acid Experimental Pharma Target 0
2,4,6-Triaminoquinazoline Experimental Pharma Target 0
2'-Monophosphoadenosine 5'-Diphosphoribose Experimental Pharma Target 0
METHYL 1-(4-{[(2,4-DIAMINOPTERIDIN-6-YL)METHYL](METHYL)AMINO}BENZOYL)PIPERIDINE-4-CARBOXYLATE Experimental Pharma Target 0
METHYL 1-(4-{[(2,4-DIAMINOPTERIDIN-6-YL)METHYL]AMINO}BENZOYL)PIPERIDINE-4-CARBOXYLATE Experimental Pharma Target 0
genes like me logo Genes that share compounds with DHRS4L1: view

Transcripts for DHRS4L1 Gene

mRNA/cDNA for DHRS4L1 Gene

(3) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DHRS4L1 Gene

Dehydrogenase/reductase (SDR family) member 4 like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS4L1 Gene

No ASD Table

Relevant External Links for DHRS4L1 Gene

GeneLoc Exon Structure for
DHRS4L1
ECgene alternative splicing isoforms for
DHRS4L1

Expression for DHRS4L1 Gene

mRNA expression in normal human tissues for DHRS4L1 Gene

mRNA differential expression in normal tissues according to GTEx for DHRS4L1 Gene

This gene is overexpressed in Testis (x10.0) and Liver (x4.5).

Protein differential expression in normal tissues from HIPED for DHRS4L1 Gene

This gene is overexpressed in Retina (25.2), Heart (22.9), and Skin (20.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DHRS4L1 Gene



SOURCE GeneReport for Unigene cluster for DHRS4L1 Gene Hs.647569

genes like me logo Genes that share expression patterns with DHRS4L1: view

Protein tissue co-expression partners for DHRS4L1 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DHRS4L1 Gene

Orthologs for DHRS4L1 Gene

Evolution for DHRS4L1 Gene

ENSEMBL:
Gene Tree for DHRS4L1 (if available)
TreeFam:
Gene Tree for DHRS4L1 (if available)

No data available for Orthologs for DHRS4L1 Gene

Paralogs for DHRS4L1 Gene

(5) SIMAP similar genes for DHRS4L1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DHRS4L1: view

No data available for Paralogs for DHRS4L1 Gene

Variants for DHRS4L1 Gene

Sequence variations from dbSNP and Humsavar for DHRS4L1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs177938 -- 24,030,184(-) ggtat(A/T)tctag intron-variant
rs177941 -- 24,027,550(-) tgtcc(A/C)agaga intron-variant
rs177942 -- 24,026,096(-) tgaga(A/T)ggtat intron-variant
rs177943 -- 24,025,819(-) gctgt(G/T)ctgaa intron-variant
rs177944 -- 24,025,599(-) tgagt(G/T)aattt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHRS4L1 Gene

Variant ID Type Subtype PubMed ID
nsv1217 CNV Loss 18451855
nsv901497 CNV Gain 21882294
nsv826901 CNV Loss 20364138
esv2748488 CNV Deletion 23290073
nsv9126 CNV Gain 18304495
nsv516023 CNV Loss 19592680
nsv482170 CNV Gain 20164927
esv272219 CNV Insertion 20981092

Relevant External Links for DHRS4L1 Gene

HapMap Linkage Disequilibrium report
DHRS4L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for DHRS4L1 Gene

Disorders for DHRS4L1 Gene

Relevant External Links for DHRS4L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHRS4L1
genes like me logo Genes that share disorders with DHRS4L1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHRS4L1 Gene

Publications for DHRS4L1 Gene

  1. AS1DHRS4, a head-to-head natural antisense transcript, silences the DHRS4 gene cluster in cis and trans. (PMID: 22891334) Li Q. … Huang D. (Proc. Natl. Acad. Sci. U.S.A. 2012) 2 67
  2. Bioinformatic analysis of the human DHRS4 gene cluster and a proposed mechanism for its transcriptional regulation. (PMID: 20525226) Su Z.J. … Huang D.Y. (BMC Mol. Biol. 2010) 2 67
  3. Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase. (PMID: 10333503) Fransen M. … Subramani S. (Biochem. J. 1999) 2 67
  4. Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes. (PMID: 23036705) Gabrielli F. … Tofanelli S. (Gene 2012) 67
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 67

Products for DHRS4L1 Gene

Sources for DHRS4L1 Gene

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