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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DHRS4L1 Gene

protein-coding   GIFtS: 37
GCID: GC14P024505

Dehydrogenase/Reductase (SDR Family) Member 4 Like 1

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dehydrogenase/Reductase (SDR Family) Member 4 Like 11 2     Putative Dehydrogenase/Reductase SDR Family Member 4-Like 22
Member 41     Short Chain Dehydrogenase/Reductase Family 25C, Member 42
Short Chain Dehydrogenase/Reductase Family 25C1     EC 1.1.-.-3
SDR25C42     

External Ids:    HGNC: 197321   Entrez Gene: 7286352   Ensembl: ENSG000002257667   OMIM: 6151955   UniProtKB: P0CG223   

Export aliases for DHRS4L1 gene to outside databases

Previous GC identifers: GC00U906276 GC14U900438 GC14P023577 GC14P004620


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DHRS4L1 Gene: 
DHRS4L1 (dehydrogenase/reductase (SDR family) member 4 like 1) is a protein-coding gene. Diseases associated with DHRS4L1 include tuberculosis, and among its related super-pathways are Metabolism and Drug metabolism - cytochrome P450. GO annotations related to this gene include oxidoreductase activity and nucleotide binding.

UniProtKB/Swiss-Prot: DR4L1_HUMAN, P0CG22
Function: Putative oxidoreductase (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DHRS4L1 gene promoter:
         TBP   USF1   USF2   USF-1:USF-2   POU6F1 (c2)   HEN1   TFIID   USF-1   Cart-1   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for DHRS4L1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHRS4L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

DHRS4L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHRS4L1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P024505:  view genomic region     (about GC identifiers)

Start:
24,505,662 bp from pter      End:
24,520,580 bp from pter
Size:
14,919 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DR4L1_HUMAN, P0CG22 (See protein sequence)
Recommended Name: Putative dehydrogenase/reductase SDR family member 4-like 2  
Size: 281 amino acids; 30608 Da
Caution: Product of a dubious CDS prediction

Explore the universe of human proteins at neXtProt for DHRS4L1: NX_P0CG22

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P0CG22

  • DHRS4L1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_001264793.1  
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SDRC1: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 1

    4 InterPro protein domains:
     IPR020904 Sc_DH/Rdtase_CS
     IPR002347 Glc/ribitol_DH
     IPR016040 NAD(P)-bd_dom
     IPR027052 DHRS2/4

    Graphical View of Domain Structure for InterPro Entry P0CG22

    ProtoNet protein and cluster: P0CG22

    UniProtKB/Swiss-Prot: DR4L1_HUMAN, P0CG22
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    DHRS4L1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DR4L1_HUMAN, P0CG22
    Function: Putative oxidoreductase (By similarity)

         Enzyme Number (IUBMB): EC 1.1.-.-1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016491oxidoreductase activity IEA--
         
    DHRS4L1 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DHRS4L1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.40
    2Drug metabolism - cytochrome P450
    Retinol metabolism0.39
    3Peroxisome
    Peroxisome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3         Kegg Pathways  (Kegg details for DHRS4L1):
        Retinol metabolism
    Metabolic pathways
    Peroxisome


    DHRS4L1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DHRS4L1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DHRS4L1 (DR4L1)

    5 DrugBank Compounds for DHRS4L1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    10-Propargyl-5,8-Dideazafolic Acid-- --target--10592235
    2'-Monophosphoadenosine 5'-Diphosphoribose-- --target--10592235
    2,4,6-Triaminoquinazoline-- --target--10592235
    METHYL 1-(4-{[(2,4-DIAMINOPTERIDIN-6-YL)METHYL](METHYL)AMINO}BENZOYL)PIPERIDINE-4-CARBOXYLATE-- --target--10592235
    METHYL 1-(4-{[(2,4-DIAMINOPTERIDIN-6-YL)METHYL]AMINO}BENZOYL)PIPERIDINE-4-CARBOXYLATE-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about DHRS4L1 / DR4L1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DHRS4L1 gene (2 alternative transcripts): 
    NM_001082488.1  NM_001277864.1  

    Unigene Cluster for DHRS4L1:

    Dehydrogenase/reductase (SDR family) member 4 like 1
    Hs.647569  [show with all ESTs]
    Unigene Representative Sequence: BX647440
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000559270(uc021rrg.1 uc021rrh.1 uc021rri.1 uc021rrj.1)
    ENST00000558293(uc010tnu.2) ENST00000558682 ENST00000558622 ENST00000397065(uc021rrd.1 uc010alc.3)
    ENST00000606840
    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate DHRS4L1 (see all 9):
    hsa-miR-4291 hsa-miR-1266 hsa-miR-214 hsa-miR-2355-5p hsa-miR-330-3p hsa-miR-3153 hsa-miR-761 hsa-miR-450b-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of DHRS4L1 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DHRS4L1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHRS4L1

    Additional mRNA sequence: 

    BC171914.1 BC171918.1 BX647440.1 GQ871921.1 GQ871922.1 GQ871923.1 GQ871924.1 GQ871925.1 
    GQ871926.1 GQ871927.1 

    6 DOTS entries:

    DT.40286930  DT.97790439  DT.100800245  DT.40230863  DT.447164  DT.100825829 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DHRS4L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DHRS4L1 Expression
    About this image


    SOURCE GeneReport for Unigene cluster: Hs.647569
        SABiosciences Custom PCR Arrays for DHRS4L1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHRS4L1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for DHRS4L1 (if available)
    TreeFam Gene Tree for DHRS4L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DHRS4L1 gene
    5 SIMAP similar genes for DHRS4L1 using alignment to 1 protein entry:     DR4L1_HUMAN:
    DHRS2    DHRS4    DHRS4L2    CBR4    DCXR

    DHRS4L1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/901 SNPs in DHRS4L1 are shown (see all 901)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1490289891,2
    Cuntested124517095(+) TTCTGA/GGCCAA 8 -- int10--------
    rs1848290131,2
    C--24476128(+) CTCACA/GCCGAC 3 -- us2k10--------
    rs1488898091,2
    C--24476433(+) GGTCAC/GGGTGG 3 -- ut51 nc-transcript-variant0--------
    rs1892045811,2
    --24476574(+) CACCCC/GGCTAC 3 -- ut51 nc-transcript-variant0--------
    rs1390080861,2
    --24476597(+) GACTCC/TAAGGC 3 -- ut51 nc-transcript-variant0--------
    rs3739787051,2
    C--24476689(+) GGCCG-/GGGGGGGG 4 -- int1 cds10--------
    rs1818082901,2
    --24476714(+) CATCAA/GTTAAC 3 -- int10--------
    rs1406329781,2
    --24476720(+) TTAACC/GGGGCC 3 -- int10--------
    rs1504493101,2
    --24476722(+) AACGGC/GGCCGT 3 -- int10--------
    rs40485871,2
    C--24476732(+) tggggG/Aaagga 3 -- int11Minor allele frequency- A:0.00NA 2

    HapMap Linkage Disequilibrium report for DHRS4L1 (24505662 - 24520580 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for DHRS4L1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2748488CNV Deletion23290073
    esv272219CNV Insertion20981092
    nsv826901CNV Loss20364138
    nsv516023CNV Loss19592680
    nsv1217CNV Loss18451855
    nsv482170CNV Gain20164927
    nsv901497CNV Gain21882294
    nsv9126CNV Gain18304495


    Human Gene Mutation Database (HGMD): DHRS4L1
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing DHRS4L1
    DNA2.0 Custom Variant and Variant Library Synthesis for DHRS4L1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 615195    OMIM disorders: --

    2 diseases for DHRS4L1:    About MalaCards
    tuberculosis    


    DHRS4L1 for disorders           About GeneDecksing


    Export disorders for DHRS4L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DHRS4L1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with DHRS4L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
    2. Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase. (PubMed id 10333503)1, 3 Fransen M.... Subramani S. (1999)
    3. Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes. (PubMed id 23036705)1 Gabrielli F. and Tofanelli S. (2012)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    5. Bioinformatic analysis of the human DHRS4 gene cluste r and a proposed mechanism for its transcriptional regulation. (PubMed id 20525226)1 Su Z.J....Huang D.Y. (2010)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 728635 HGNC: 19732 Ensembl:ENSG00000225766 euGenes: HUgn728635 ECgene: DHRS4L1 Kegg: 728635
    H-InvDB: DHRS4L1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DHRS4L1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DHRS4L1 gene:
    Search GeneIP for patents involving DHRS4L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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