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Aliases for DHRS4L1 Gene

Aliases for DHRS4L1 Gene

  • Dehydrogenase/Reductase (SDR Family) Member 4 Like 1 2 3
  • Short Chain Dehydrogenase/Reductase Family 25C Member 4 3 4
  • SDR25C4 3 4
  • Putative Dehydrogenase/Reductase SDR Family Member 4-Like 2 3
  • Putative Dehydrogenase/Reductase SDR Family Member 4-Like 1 3
  • Short Chain Dehydrogenase/Reductase Family 25C, Member 4 3
  • Short Chain Dehydrogenase/Reductase Family 25C 2
  • EC 1.1.-.- 4
  • Member 4 2

External Ids for DHRS4L1 Gene

Previous GeneCards Identifiers for DHRS4L1 Gene

  • GC00U906276
  • GC14U900438
  • GC14P023577
  • GC14P024505
  • GC14P004620

Summaries for DHRS4L1 Gene

GeneCards Summary for DHRS4L1 Gene

DHRS4L1 (Dehydrogenase/Reductase (SDR Family) Member 4 Like 1) is a Protein Coding gene. Among its related pathways are Metabolism and Peroxisome. GO annotations related to this gene include oxidoreductase activity.

UniProtKB/Swiss-Prot for DHRS4L1 Gene

  • Putative oxidoreductase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS4L1 Gene

Genomics for DHRS4L1 Gene

Regulatory Elements for DHRS4L1 Gene

Genomic Location for DHRS4L1 Gene

24,007,009 bp from pter
24,051,377 bp from pter
44,369 bases
Plus strand

Genomic View for DHRS4L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHRS4L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS4L1 Gene

Proteins for DHRS4L1 Gene

  • Protein details for DHRS4L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative dehydrogenase/reductase SDR family member 4-like 1
    Protein Accession:
    Secondary Accessions:

    Protein attributes for DHRS4L1 Gene

    281 amino acids
    Molecular mass:
    30608 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DHRS4L1 Gene

Proteomics data for DHRS4L1 Gene at MOPED

Post-translational modifications for DHRS4L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHRS4L1 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for DHRS4L1 Gene

Domains for DHRS4L1 Gene

Gene Families for DHRS4L1 Gene

  • SDRC1 :Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 1

Protein Domains for DHRS4L1 Gene

Suggested Antigen Peptide Sequences for DHRS4L1 Gene

Graphical View of Domain Structure for InterPro Entry



  • P0CG22
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS4L1: view

Function for DHRS4L1 Gene

Molecular function for DHRS4L1 Gene

UniProtKB/Swiss-Prot Function:
Putative oxidoreductase.

Enzyme Numbers (IUBMB) for DHRS4L1 Gene

Gene Ontology (GO) - Molecular Function for DHRS4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with DHRS4L1: view

Animal Model Products

CRISPR Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DHRS4L1 Gene

Localization for DHRS4L1 Gene

Subcellular locations from

Jensen Localization Image for DHRS4L1 Gene COMPARTMENTS Subcellular localization image for DHRS4L1 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DHRS4L1 Gene

Pathways for DHRS4L1 Gene

genes like me logo Genes that share pathways with DHRS4L1: view

Pathways by source for DHRS4L1 Gene

3 KEGG pathways for DHRS4L1 Gene

Interacting Proteins for DHRS4L1 Gene

Gene Ontology (GO) - Biological Process for DHRS4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DHRS4L1: view

Transcripts for DHRS4L1 Gene

mRNA/cDNA for DHRS4L1 Gene

(10) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DHRS4L1 Gene

Dehydrogenase/reductase (SDR family) member 4 like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DHRS4L1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS4L1 Gene

No ASD Table

Relevant External Links for DHRS4L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHRS4L1 Gene

mRNA expression in normal human tissues for DHRS4L1 Gene

mRNA differential expression in normal tissues according to GTEx for DHRS4L1 Gene

This gene is overexpressed in Testis (10.0) and Liver (4.5).

Protein differential expression in normal tissues for DHRS4L1 Gene

This gene is overexpressed in Retina (25.2), Heart (22.9), and Skin (20.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DHRS4L1 Gene

SOURCE GeneReport for Unigene cluster for DHRS4L1 Gene Hs.647569

genes like me logo Genes that share expressions with DHRS4L1: view

Expression partners for DHRS4L1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DHRS4L1 Gene

Orthologs for DHRS4L1 Gene

Evolution for DHRS4L1 Gene

Gene Tree for DHRS4L1 (if available)
Gene Tree for DHRS4L1 (if available)

No data available for Orthologs for DHRS4L1 Gene

Paralogs for DHRS4L1 Gene

Selected SIMAP similar genes for DHRS4L1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DHRS4L1: view

No data available for Paralogs for DHRS4L1 Gene

Variants for DHRS4L1 Gene

Sequence variations from dbSNP and Humsavar for DHRS4L1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1885709 -- 24,039,063(-) CTTAC(A/G)TGTGA intron-variant
rs1885812 -- 24,035,250(+) GCAAA(C/G)GTATA intron-variant, upstream-variant-2KB
rs2006084 -- 24,033,667(-) TGGCA(C/T)GTGCC intron-variant
rs2006085 -- 24,033,391(-) AGGGA(C/G)AAATG intron-variant
rs2006252 -- 24,033,556(-) GGCAA(C/T)AGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHRS4L1 Gene

Variant ID Type Subtype PubMed ID
nsv1217 CNV Loss 18451855
nsv901497 CNV Gain 21882294
nsv826901 CNV Loss 20364138
esv2748488 CNV Deletion 23290073
nsv9126 CNV Gain 18304495
nsv516023 CNV Loss 19592680
nsv482170 CNV Gain 20164927
esv272219 CNV Insertion 20981092

Relevant External Links for DHRS4L1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHRS4L1 Gene

Disorders for DHRS4L1 Gene

No disorders were found for DHRS4L1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for DHRS4L1 Gene

Publications for DHRS4L1 Gene

  1. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4
  2. Bioinformatic analysis of the human DHRS4 gene cluster and a proposed mechanism for its transcriptional regulation. (PMID: 20525226) Su Z.J. … Huang D.Y. (BMC Mol. Biol. 2010) 2 3
  3. AS1DHRS4, a head-to-head natural antisense transcript, silences the DHRS4 gene cluster in cis and trans. (PMID: 22891334) Li Q. … Huang D. (Proc. Natl. Acad. Sci. U.S.A. 2012) 2 3
  4. Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase. (PMID: 10333503) Fransen M. … Subramani S. (Biochem. J. 1999) 2 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for DHRS4L1 Gene

Sources for DHRS4L1 Gene

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