DHRS4L1 Gene
protein-coding GIFtS: 33
GCID: GC14P024505
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dehydrogenase/reductase (SDR family) member 4 like 1
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Aliases
for DHRS4L1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dehydrogenase/Reductase (SDR Family) Member 4 Like 11 2 | | SDR25C41 2 | | Putative Dehydrogenase/Reductase SDR Family Member 4-Like 22 | | Short Chain Dehydrogenase/Reductase Family 25C, Member 42 | | EC 1.1.-.-3 |
Export aliases for DHRS4L1 gene to outside databasesPrevious GC identifers: GC00U906276 GC14U900438 GC14P023577 GC14P004620 |
Summaries
for DHRS4L1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: DR4L1_HUMAN, P0CG22Function: Putative oxidoreductase (By similarity)
|
Genomic Views
for DHRS4L1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DHRS4L1 gene promoter:
TBP USF1 USF2 USF-1:USF-2 POU6F1 (c2) HEN1 TFIID USF-1 Cart-1 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for DHRS4L1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHRS4L1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.2DHRS4L1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P024505: view genomic region
(about GC identifiers)
Start:
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24,505,662 bp from pter |
End:
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24,520,580 bp from pter |
Size:
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14,919 bases |
Orientation:
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plus strand |
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Proteins
for DHRS4L1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DR4L1_HUMAN, P0CG22 (See
protein sequence)Recommended Name: Putative dehydrogenase/reductase SDR family member 4-like 2 Size: 281 amino acids; 30608 Da
Caution: Product of a dubious CDS predictionExplore the universe of human proteins at neXtProt for DHRS4L1: NX_P0CG22
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P0CG22
DHRS4L1 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001075957.1
Human Recombinant Protein Products:
DHRS4L1 Antibody Products:
Assay Products for DHRS4L1: |
Protein
Domains /
Families
for DHRS4L1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DHRS4L1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P0CG22ProtoNet protein and cluster: P0CG22 UniProtKB/Swiss-Prot: DR4L1_HUMAN, P0CG22Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family |
Function
for DHRS4L1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DR4L1_HUMAN, P0CG22Function: Putative oxidoreductase (By similarity)Enzyme Number (IUBMB): EC 1.1.-.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DHRS4L1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DHRS4L1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DHRS4L1 (NM_001082488) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHRS4L1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0016491 | oxidoreductase activity |
IEA | -- |
DHRS4L1 for ontologies About GeneDecksing
|
Pathways & Interactions
for DHRS4L1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DHRS4L1
|
Drugs & Compounds
for DHRS4L1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DHRS4L1
5 DrugBank Compounds for DHRS4L1 About this table
Search CenterWatch for drugs/clinical trials and news about DHRS4L1 / DR4L1
|
Transcripts
for DHRS4L1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DHRS4L1 gene: NM_001082488.1 Unigene Cluster for DHRS4L1: Dehydrogenase/reductase (SDR family) member 4 like 1 Hs.647569 [show with all ESTs]Unigene Representative Sequence: BX6474405 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000559270(uc021rrg.1 uc021rrh.1 uc021rri.1 uc021rrj.1)
ENST00000558293(uc010tnu.2) ENST00000558682 ENST00000558622 ENST00000397065(uc021rrd.1 uc010alc.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DHRS4L1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DHRS4L1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DHRS4L1 (NM_001082488) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DHRS4L1 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DHRS4L1 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DHRS4L1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat DHRS4L1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DHRS4L1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHRS4L1 |
Additional cDNA sequence: AK314448.1 BC171914.1 BC171918.1 BX647440.1 GQ871921.1 GQ871922.1 GQ871923.1 GQ871924.1 GQ871925.1 GQ871926.1 GQ871927.1 6 DOTS entries: DT.40286930 DT.97790439 DT.100800245 DT.40230863 DT.447164 DT.100825829
GeneLoc Exon Structure
|
Expression
for DHRS4L1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DHRS4L1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
SOURCE GeneReport for Unigene cluster: Hs.647569
SABiosciences Custom PCR Arrays for DHRS4L1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DHRS4L1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat DHRS4L1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DHRS4L1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHRS4L1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHRS4L1 |
Orthologs
for DHRS4L1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for DHRS4L1 (if available)
TreeFam Gene Tree for DHRS4L1 (if available) |
Paralogs
for DHRS4L1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DHRS4L1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DHRS4L1 (24505662 - 24520580 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for DHRS4L1
6 CNVs: 76593 87143 49326 76591 76592 87144
Human Gene Mutation Database (HGMD): DHRS4L1
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for DHRS4L1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DHRS4L1 for disorders About GeneDecksing
2  diseases for DHRS4L1: About MalaCardstuberculosis mycobacterium tuberculosis
Export disorders for DHRS4L1 gene to outside databases
|
Publications
for DHRS4L1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DHRS4L1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DHRS4L1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
- Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase. (PubMed id 10333503)1, 3 Fransen M.... Subramani S. (1999)
- Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes. (PubMed id 23036705)1 Gabrielli F. and Tofanelli S. (2012)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (2000)
|
External Searches for DHRS4L1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing DHRS4L1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DHRS4L1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DHRS4L1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DHRS4L1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for DHRS4L1 gene:
Search GeneIP for patents involving DHRS4L1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DHRS4L1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DHRS4L1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DHRS4L1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DHRS4L1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DHRS4L1 | | OriGene 3'-UTR Clone for DHRS4L1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DHRS4L1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DHRS4L1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DHRS4L1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DHRS4L1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHRS4L1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DHRS4L1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHRS4L1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DHRS4L1 |
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| | | | Search Tocris compounds for DHRS4L1 |
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 | | | DHRS4L1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHRS4L1 |
|  |  |  | | | | Search ThermoFisher Antibodies for DHRS4L1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DHRS4L1 |
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