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Aliases for DHRS4L1 Gene

Aliases for DHRS4L1 Gene

  • Dehydrogenase/Reductase 4 Like 1 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 25C Member 4 3 4
  • Dehydrogenase/Reductase (SDR Family) Member 4 Like 1 2 3
  • SDR25C4 3 4
  • Putative Dehydrogenase/Reductase SDR Family Member 4-Like 2 3
  • Putative Dehydrogenase/Reductase SDR Family Member 4-Like 1 3
  • Short Chain Dehydrogenase/Reductase Family 25C, Member 4 2
  • EC 1.1.-.- 4

External Ids for DHRS4L1 Gene

Previous GeneCards Identifiers for DHRS4L1 Gene

  • GC00U906276
  • GC14U900438
  • GC14P023577
  • GC14P024505
  • GC14P004620

Summaries for DHRS4L1 Gene

GeneCards Summary for DHRS4L1 Gene

DHRS4L1 (Dehydrogenase/Reductase 4 Like 1) is a Protein Coding gene. Among its related pathways are Signaling by Retinoic Acid and Peroxisome. GO annotations related to this gene include oxidoreductase activity.

UniProtKB/Swiss-Prot for DHRS4L1 Gene

  • Putative oxidoreductase.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS4L1 Gene

Genomics for DHRS4L1 Gene

Regulatory Elements for DHRS4L1 Gene

Enhancers for DHRS4L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G024035 1.1 ENCODE 19.2 +29.6 29588 1.7 HDGF ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 ZNF143 DHRS4L1 RNA5SP383 KHNYN C14orf119 LOC102724814 DHRS4L2 DHRS4 PCK2 NRL HOMEZ
GH14G023159 1.6 Ensembl ENCODE dbSUPER 4.6 -844.6 -844550 5.2 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B ZNF2 SLC30A9 ZNF143 FOS PABPN1 PSMB5 DHRS4L1 DHRS4L2 RNU6-1138P SLC7A8
GH14G023988 0.9 ENCODE 7.9 -17.8 -17793 1.9 ELF3 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 RAD21 RARA DHRS4L2 DHRS4L1 DHRS4-AS1
GH14G024051 1 ENCODE 5.1 +45.0 45043 1.3 ARID4B SIN3A DMAP1 ZNF48 GLIS2 ELK1 ZNF207 KLF7 SP3 SP5 CARMIL3 DHRS4L1 LOC105370412
GH14G024240 1.7 FANTOM5 ENCODE dbSUPER 1.8 +235.2 235232 3.8 PKNOX1 CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 KHNYN RNA5SP383 LOC102724814 NYNRIN ENSG00000259321 TGM1 IRF9 TINF2 PSME1 RNF31
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DHRS4L1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DHRS4L1 Gene

Chromosome:
14
Start:
24,007,009 bp from pter
End:
24,051,377 bp from pter
Size:
44,369 bases
Orientation:
Plus strand

Genomic View for DHRS4L1 Gene

Genes around DHRS4L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHRS4L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHRS4L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS4L1 Gene

Proteins for DHRS4L1 Gene

  • Protein details for DHRS4L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG22-DR4L1_HUMAN
    Recommended name:
    Putative dehydrogenase/reductase SDR family member 4-like 1
    Protein Accession:
    P0CG22

    Protein attributes for DHRS4L1 Gene

    Size:
    281 amino acids
    Molecular mass:
    30608 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DHRS4L1 Gene

Post-translational modifications for DHRS4L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHRS4L1 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for DHRS4L1 Gene

Domains & Families for DHRS4L1 Gene

Gene Families for DHRS4L1 Gene

Protein Domains for DHRS4L1 Gene

Suggested Antigen Peptide Sequences for DHRS4L1 Gene

Graphical View of Domain Structure for InterPro Entry

P0CG22

UniProtKB/Swiss-Prot:

DR4L1_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS4L1: view

Function for DHRS4L1 Gene

Molecular function for DHRS4L1 Gene

UniProtKB/Swiss-Prot Function:
Putative oxidoreductase.

Enzyme Numbers (IUBMB) for DHRS4L1 Gene

Gene Ontology (GO) - Molecular Function for DHRS4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with DHRS4L1: view

Phenotypes for DHRS4L1 Gene

genes like me logo Genes that share phenotypes with DHRS4L1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DHRS4L1 Gene

Localization for DHRS4L1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for DHRS4L1 Gene

Pathways & Interactions for DHRS4L1 Gene

genes like me logo Genes that share pathways with DHRS4L1: view

Pathways by source for DHRS4L1 Gene

3 KEGG pathways for DHRS4L1 Gene

Interacting Proteins for DHRS4L1 Gene

Gene Ontology (GO) - Biological Process for DHRS4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DHRS4L1: view

No data available for SIGNOR curated interactions for DHRS4L1 Gene

Drugs & Compounds for DHRS4L1 Gene

(5) Drugs for DHRS4L1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
10-Propargyl-5,8-Dideazafolic Acid Experimental Pharma Target 0
2,4,6-Triaminoquinazoline Experimental Pharma Target 0
2'-Monophosphoadenosine 5'-Diphosphoribose Experimental Pharma Target 0
METHYL 1-(4-{[(2,4-DIAMINOPTERIDIN-6-YL)METHYL](METHYL)AMINO}BENZOYL)PIPERIDINE-4-CARBOXYLATE Experimental Pharma Target 0
METHYL 1-(4-{[(2,4-DIAMINOPTERIDIN-6-YL)METHYL]AMINO}BENZOYL)PIPERIDINE-4-CARBOXYLATE Experimental Pharma Target 0
genes like me logo Genes that share compounds with DHRS4L1: view

Transcripts for DHRS4L1 Gene

mRNA/cDNA for DHRS4L1 Gene

(3) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DHRS4L1 Gene

Dehydrogenase/reductase (SDR family) member 4 like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS4L1 Gene

No ASD Table

Relevant External Links for DHRS4L1 Gene

GeneLoc Exon Structure for
DHRS4L1
ECgene alternative splicing isoforms for
DHRS4L1

Expression for DHRS4L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHRS4L1 Gene

mRNA differential expression in normal tissues according to GTEx for DHRS4L1 Gene

This gene is overexpressed in Testis (x10.0) and Liver (x4.5).

Protein differential expression in normal tissues from HIPED for DHRS4L1 Gene

This gene is overexpressed in Retina (25.2), Heart (22.9), and Skin (20.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DHRS4L1 Gene



Protein tissue co-expression partners for DHRS4L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DHRS4L1 Gene:

DHRS4L1

SOURCE GeneReport for Unigene cluster for DHRS4L1 Gene:

Hs.647569
genes like me logo Genes that share expression patterns with DHRS4L1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHRS4L1 Gene

Orthologs for DHRS4L1 Gene

Evolution for DHRS4L1 Gene

ENSEMBL:
Gene Tree for DHRS4L1 (if available)
TreeFam:
Gene Tree for DHRS4L1 (if available)

No data available for Orthologs for DHRS4L1 Gene

Paralogs for DHRS4L1 Gene

(5) SIMAP similar genes for DHRS4L1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DHRS4L1: view

No data available for Paralogs for DHRS4L1 Gene

Variants for DHRS4L1 Gene

Sequence variations from dbSNP and Humsavar for DHRS4L1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000028445 -- 24,015,577(+) CCTCT(A/G)TCTCA intron-variant
rs1000080314 -- 24,015,376(+) ACGTG(C/T)ATGTA intron-variant
rs1000122181 -- 24,050,612(+) AAAAA(A/C)CAGTG intron-variant, upstream-variant-2KB
rs1000374277 -- 24,010,443(+) GATGA(C/G)TTTTA intron-variant
rs1000569293 -- 24,018,921(+) AAACT(A/T)TCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHRS4L1 Gene

Variant ID Type Subtype PubMed ID
dgv1838n100 CNV gain 25217958
dgv1839n100 CNV loss 25217958
dgv1840n100 CNV gain+loss 25217958
dgv1841n100 CNV gain+loss 25217958
dgv1842n100 CNV loss 25217958
dgv1843n100 CNV gain+loss 25217958
dgv1844n100 CNV gain 25217958
dgv1845n100 CNV loss 25217958
dgv1846n100 CNV loss 25217958
dgv1847n100 CNV gain 25217958
dgv1848n100 CNV gain 25217958
dgv1849n100 CNV gain 25217958
dgv1850n100 CNV gain 25217958
dgv1851n100 CNV gain+loss 25217958
dgv1852n100 CNV loss 25217958
dgv1853n100 CNV gain 25217958
dgv3580n54 CNV loss 21841781
dgv3581n54 CNV loss 21841781
dgv36e203 CNV gain+loss 21179565
dgv384e214 CNV loss 21293372
dgv617e212 CNV loss 25503493
dgv618e212 CNV loss 25503493
esv2421714 CNV deletion 20811451
esv25830 CNV loss 19812545
esv2658227 CNV deletion 23128226
esv2748488 CNV deletion 23290073
esv33403 CNV loss 17666407
esv3344705 CNV insertion 20981092
esv3551253 CNV deletion 23714750
esv3633794 CNV loss 21293372
esv3633799 CNV gain 21293372
esv3633800 CNV gain 21293372
esv3892478 CNV loss 25118596
nsv1036658 CNV loss 25217958
nsv1038278 CNV gain+loss 25217958
nsv1042507 CNV gain 25217958
nsv1043854 CNV gain 25217958
nsv1051893 CNV gain+loss 25217958
nsv1052180 CNV loss 25217958
nsv1217 CNV deletion 18451855
nsv1219 CNV insertion 18451855
nsv436015 CNV insertion 17901297
nsv436830 CNV insertion 17901297
nsv472053 CNV novel sequence insertion 20440878
nsv482170 CNV gain 20164927
nsv510630 CNV deletion 20534489
nsv511030 OTHER complex 20534489
nsv512352 CNV loss 21212237
nsv513749 CNV insertion 21212237
nsv516023 CNV loss 19592680
nsv564046 CNV loss 21841781
nsv564047 CNV loss 21841781
nsv564048 CNV loss 21841781
nsv564051 CNV loss 21841781
nsv564052 CNV gain 21841781
nsv564056 CNV loss 21841781
nsv826901 CNV loss 20364138
nsv91 CNV deletion 15895083
nsv9126 CNV gain 18304495
nsv983808 CNV duplication 23825009

Relevant External Links for DHRS4L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DHRS4L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for DHRS4L1 Gene

Disorders for DHRS4L1 Gene

Relevant External Links for DHRS4L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHRS4L1

No disorders were found for DHRS4L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHRS4L1 Gene

Publications for DHRS4L1 Gene

  1. AS1DHRS4, a head-to-head natural antisense transcript, silences the DHRS4 gene cluster in cis and trans. (PMID: 22891334) Li Q. … Huang D. (Proc. Natl. Acad. Sci. U.S.A. 2012) 2 3 64
  2. Bioinformatic analysis of the human DHRS4 gene cluster and a proposed mechanism for its transcriptional regulation. (PMID: 20525226) Su Z.J. … Huang D.Y. (BMC Mol. Biol. 2010) 2 3 64
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4 64
  4. Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase. (PMID: 10333503) Fransen M. … Subramani S. (Biochem. J. 1999) 2 3 64
  5. Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes. (PMID: 23036705) Gabrielli F. … Tofanelli S. (Gene 2012) 3 64

Products for DHRS4L1 Gene

Sources for DHRS4L1 Gene

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