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Aliases for DHRS4L1 Gene

Aliases for DHRS4L1 Gene

  • Dehydrogenase/Reductase 4 Like 1 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 25C Member 4 3 4
  • SDR25C4 3 4
  • Putative Dehydrogenase/Reductase SDR Family Member 4-Like 1 3
  • Putative Dehydrogenase/Reductase SDR Family Member 4-Like 2 3
  • Short Chain Dehydrogenase/Reductase Family 25C, Member 4 2
  • Dehydrogenase/Reductase (SDR Family) Member 4 Like 1 2
  • EC 1.1.-.- 4

External Ids for DHRS4L1 Gene

Previous GeneCards Identifiers for DHRS4L1 Gene

  • GC00U906276
  • GC14U900438
  • GC14P023577
  • GC14P024505
  • GC14P004620

Summaries for DHRS4L1 Gene

GeneCards Summary for DHRS4L1 Gene

DHRS4L1 (Dehydrogenase/Reductase 4 Like 1) is a Protein Coding gene. Among its related pathways are Peroxisome and Metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity.

UniProtKB/Swiss-Prot for DHRS4L1 Gene

  • Putative oxidoreductase.

Additional gene information for DHRS4L1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS4L1 Gene

Genomics for DHRS4L1 Gene

GeneHancer (GH) Regulatory Elements for DHRS4L1 Gene

Promoters and enhancers for DHRS4L1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I024006 Enhancer 1 Ensembl ENCODE 550.8 0.0 -8 2 FOXA2 KLF17 SIN3A ZNF2 ZNF335 RCOR1 EGR2 ZNF398 ZEB2 ZNF610 DHRS4L1 DHRS4L2 C14orf93 ADCY4 DHRS4-AS1
GH14I024035 Promoter/Enhancer 1.5 Ensembl ENCODE 19.2 +29.6 29588 1.7 HDGF ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 ZNF213 PIR58946 ACIN1 DHRS4L1 RNA5SP383 KHNYN TM9SF1 C14orf119 LOC102724814 DHRS4L2 RNF31
GH14I023988 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 7.9 -17.8 -17792 1.9 ELF3 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 BATF ZNF48 RAD21 DHRS4L2 DHRS4-AS1 PIR45783 DHRS4L1
GH14I023969 Promoter 1.6 EPDnew Ensembl 8.3 -36.9 -36908 0.6 FOXA2 RB1 ARID4B DMAP1 ZNF48 THAP11 MIXL1 MXD4 MIER2 KAT8 DHRS4L2 DHRS4L1 NYNRIN DHRS4-AS1 PIR45783
GH14I024051 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 5.1 +45.0 45043 1.3 ARID4B SIN3A DMAP1 ZNF48 GLIS2 ELK1 ZNF207 KLF7 SP3 SP5 CARMIL3 DHRS4L1 LOC105370412
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DHRS4L1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DHRS4L1 gene promoter:

Genomic Locations for DHRS4L1 Gene

Genomic Locations for DHRS4L1 Gene
44,369 bases
Plus strand

Genomic View for DHRS4L1 Gene

Genes around DHRS4L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHRS4L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHRS4L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS4L1 Gene

Proteins for DHRS4L1 Gene

  • Protein details for DHRS4L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative dehydrogenase/reductase SDR family member 4-like 1
    Protein Accession:

    Protein attributes for DHRS4L1 Gene

    281 amino acids
    Molecular mass:
    30608 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DHRS4L1 Gene

Post-translational modifications for DHRS4L1 Gene

No Post-translational modifications

Other Protein References for DHRS4L1 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for DHRS4L1 Gene

Domains & Families for DHRS4L1 Gene

Gene Families for DHRS4L1 Gene

Protein Domains for DHRS4L1 Gene

Suggested Antigen Peptide Sequences for DHRS4L1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS4L1: view

Function for DHRS4L1 Gene

Molecular function for DHRS4L1 Gene

UniProtKB/Swiss-Prot Function:
Putative oxidoreductase.

Enzyme Numbers (IUBMB) for DHRS4L1 Gene

Phenotypes From GWAS Catalog for DHRS4L1 Gene

Gene Ontology (GO) - Molecular Function for DHRS4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with DHRS4L1: view

Phenotypes for DHRS4L1 Gene

genes like me logo Genes that share phenotypes with DHRS4L1: view

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DHRS4L1 Gene

Localization for DHRS4L1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for DHRS4L1 Gene

Pathways & Interactions for DHRS4L1 Gene

genes like me logo Genes that share pathways with DHRS4L1: view

Pathways by source for DHRS4L1 Gene

3 KEGG pathways for DHRS4L1 Gene

Interacting Proteins for DHRS4L1 Gene

Gene Ontology (GO) - Biological Process for DHRS4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DHRS4L1: view

No data available for SIGNOR curated interactions for DHRS4L1 Gene

Drugs & Compounds for DHRS4L1 Gene

(5) Drugs for DHRS4L1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
10-Propargyl-5,8-Dideazafolic Acid Experimental Pharma Target 0
2,4,6-Triaminoquinazoline Experimental Pharma Target 0
2'-Monophosphoadenosine 5'-Diphosphoribose Experimental Pharma Target 0
genes like me logo Genes that share compounds with DHRS4L1: view

Transcripts for DHRS4L1 Gene

mRNA/cDNA for DHRS4L1 Gene

(3) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DHRS4L1 Gene

Dehydrogenase/reductase (SDR family) member 4 like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS4L1 Gene

No ASD Table

Relevant External Links for DHRS4L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHRS4L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHRS4L1 Gene

mRNA differential expression in normal tissues according to GTEx for DHRS4L1 Gene

This gene is overexpressed in Testis (x10.0) and Liver (x4.5).

Protein differential expression in normal tissues from HIPED for DHRS4L1 Gene

This gene is overexpressed in Retina (25.2), Heart (22.9), and Skin (20.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DHRS4L1 Gene

Protein tissue co-expression partners for DHRS4L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DHRS4L1 Gene:


SOURCE GeneReport for Unigene cluster for DHRS4L1 Gene:

genes like me logo Genes that share expression patterns with DHRS4L1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHRS4L1 Gene

Orthologs for DHRS4L1 Gene

Evolution for DHRS4L1 Gene

Gene Tree for DHRS4L1 (if available)
Gene Tree for DHRS4L1 (if available)

No data available for Orthologs for DHRS4L1 Gene

Paralogs for DHRS4L1 Gene

(5) SIMAP similar genes for DHRS4L1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DHRS4L1: view

No data available for Paralogs for DHRS4L1 Gene

Variants for DHRS4L1 Gene

Sequence variations from dbSNP and Humsavar for DHRS4L1 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000028445 -- 24,015,577(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000080314 -- 24,015,376(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000122181 -- 24,050,612(+) A/C intron_variant
rs1000374277 -- 24,010,443(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000569293 -- 24,018,921(+) A/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DHRS4L1 Gene

Variant ID Type Subtype PubMed ID
dgv1838n100 CNV gain 25217958
dgv1839n100 CNV loss 25217958
dgv1840n100 CNV gain+loss 25217958
dgv1841n100 CNV gain+loss 25217958
dgv1842n100 CNV loss 25217958
dgv1843n100 CNV gain+loss 25217958
dgv1844n100 CNV gain 25217958
dgv1845n100 CNV loss 25217958
dgv1846n100 CNV loss 25217958
dgv1847n100 CNV gain 25217958
dgv1848n100 CNV gain 25217958
dgv1849n100 CNV gain 25217958
dgv1850n100 CNV gain 25217958
dgv1851n100 CNV gain+loss 25217958
dgv1852n100 CNV loss 25217958
dgv1853n100 CNV gain 25217958
dgv3580n54 CNV loss 21841781
dgv3581n54 CNV loss 21841781
dgv36e203 CNV gain+loss 21179565
dgv384e214 CNV loss 21293372
dgv617e212 CNV loss 25503493
dgv618e212 CNV loss 25503493
esv2421714 CNV deletion 20811451
esv25830 CNV loss 19812545
esv2658227 CNV deletion 23128226
esv2748488 CNV deletion 23290073
esv33403 CNV loss 17666407
esv3344705 CNV insertion 20981092
esv3551253 CNV deletion 23714750
esv3633794 CNV loss 21293372
esv3633799 CNV gain 21293372
esv3633800 CNV gain 21293372
esv3892478 CNV loss 25118596
nsv1036658 CNV loss 25217958
nsv1038278 CNV gain+loss 25217958
nsv1042507 CNV gain 25217958
nsv1043854 CNV gain 25217958
nsv1051893 CNV gain+loss 25217958
nsv1052180 CNV loss 25217958
nsv1217 CNV deletion 18451855
nsv1219 CNV insertion 18451855
nsv436015 CNV insertion 17901297
nsv436830 CNV insertion 17901297
nsv472053 CNV novel sequence insertion 20440878
nsv482170 CNV gain 20164927
nsv510630 CNV deletion 20534489
nsv511030 OTHER complex 20534489
nsv512352 CNV loss 21212237
nsv513749 CNV insertion 21212237
nsv516023 CNV loss 19592680
nsv564046 CNV loss 21841781
nsv564047 CNV loss 21841781
nsv564048 CNV loss 21841781
nsv564051 CNV loss 21841781
nsv564052 CNV gain 21841781
nsv564056 CNV loss 21841781
nsv826901 CNV loss 20364138
nsv91 CNV deletion 15895083
nsv9126 CNV gain 18304495
nsv983808 CNV duplication 23825009

Additional Variant Information for DHRS4L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for DHRS4L1 Gene

Disorders for DHRS4L1 Gene

Additional Disease Information for DHRS4L1

No disorders were found for DHRS4L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHRS4L1 Gene

Publications for DHRS4L1 Gene

  1. AS1DHRS4, a head-to-head natural antisense transcript, silences the DHRS4 gene cluster in cis and trans. (PMID: 22891334) Li Q … Huang D (Proceedings of the National Academy of Sciences of the United States of America 2012) 2 3 58
  2. Bioinformatic analysis of the human DHRS4 gene cluster and a proposed mechanism for its transcriptional regulation. (PMID: 20525226) Su ZJ … Huang DY (BMC molecular biology 2010) 2 3 58
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4 58
  4. Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase. (PMID: 10333503) Fransen M … Subramani S (The Biochemical journal 1999) 2 3 58
  5. Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes. (PMID: 23036705) Gabrielli F … Tofanelli S (Gene 2012) 3 58

Products for DHRS4L1 Gene

Sources for DHRS4L1 Gene

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