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Set Analyses:

VarElect

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DHRS4 Gene

protein-coding GIFtS: 64
GCID: GC14P024422

Dehydrogenase/Reductase (SDR Family) Member 4

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Dehydrogenase/Reductase (SDR Family) Member 4¹ ²		Member 2¹
NRDR² ³ ⁵		Short Chain Dehydrogenase/Reductase Family 25C¹
Peroxisomal Short-Chain Alcohol Dehydrogenase² ³		SDR-SRL²
Short-Chain Dehydrogenase/Reductase Family Member 4² ³		SDR25C1²
CR² ³		SDR25C2²
PHCR² ³		Dehydrogenase/Reductase (SDR Family) Member 4 Like 2A²
PSCD² ³		Dehydrogenase/Reductase SDR Family Member 4²
SCAD-SRL² ³		Short Chain Dehydrogenase/Reductase Family 25C, Member 1²
NADPH-Dependent Carbonyl Reductase/NADP-Retinol Dehydrogenase² ³		Short Chain Dehydrogenase/Reductase Family 25C, Member 2²
NADPH-Dependent Retinol Dehydrogenase/Reductase² ³		humNRDR³
EC 1.1.1.184³ ⁸		EC 1.1.1⁸

External Ids:	HGNC: 16985¹	Entrez Gene: 10901²	Ensembl: ENSG00000157326⁷	OMIM: 611596⁵	UniProtKB: Q9BTZ2³

Export aliases for DHRS4 gene to outside databases

Previous GC identifers: GC14P018210 GC14P022413 GC14P023492 GC14P004539

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DHRS4 Gene:

DHRS4 (dehydrogenase/reductase (SDR family) member 4) is a protein-coding gene. Diseases associated with DHRS4 include estrogen-receptor positive breast cancer, and retinitis. GO annotations related to this gene include carbonyl reductase (NADPH) activity and receptor binding. An important paralog of this gene is HPGD.

UniProtKB/Swiss-Prot: DHRS4_HUMAN, Q9BTZ2

Function: Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with

NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds

with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and

4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity)

Gene Wiki entry for DHRS4 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000014.9 NT_026437.13 NC_018925.2

Regulatory elements:

Regulatory transcription factor binding sites in the DHRS4 gene promoter:
HEN1 SRF SRF (504 AA) Pax-4a
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search Chromatin IP Primers for DHRS4

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DHRS4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.2

DHRS4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHRS4 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P024422: view genomic region (about GC identifiers)

Start:	24,422,795 bp from pter	End:	24,438,488 bp from pter
Size:	15,694 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DHRS4_HUMAN, Q9BTZ2 (See protein sequence)

Recommended Name: Dehydrogenase/reductase SDR family member 4

Size: 278 amino acids; 29537 Da

Subunit: Homotetramer (By similarity)

Miscellaneous: Inhibited by kaempferol, quercetin, genistein and myristic acid (By similarity)

Sequence caution: Sequence=AAD02292.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=AAL61824.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB18775.1;

Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG37057.1; Type=Erroneous

initiation; Note=Translation N-terminally extended;

1 PDB 3D structure from and Proteopedia for DHRS4:

3O4R (3D)

Secondary accessions: B2RB10 B7WNS9 D3YTB8 E2QRL8 O95162 Q20CR0 Q2LC19 Q2LE81 Q58IU4 Q6E0Y1

Q6UWU3 Q71UQ6 Q8TD03 Q9H3N5 Q9NV08

Alternative splicing: 8 isoforms: Q9BTZ2-1 Q9BTZ2-2 Q9BTZ2-3 Q9BTZ2-4 Q9BTZ2-5 Q9BTZ2-6 Q9BTZ2-7 Q9BTZ2-8

(Enhanced dicarbonyl reductase activity. high expression in liver)

Explore the universe of human proteins at neXtProt for DHRS4: NX_Q9BTZ2

Explore proteomics data for DHRS4 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

Selected DME Specific Peptides for DHRS4 (Q9BTZ2) (see all 8)

TEEVWDK

NKVALVT

APGLIKT

SSRKQQNVD

See DHRS4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (6 alternative transcripts):

NP_001269916.1 NP_001269917.1 NP_001269918.1 NP_001269919.1 NP_001269920.1 NP_066284.2

ENSEMBL proteins:

ENSP00000326219 ENSP00000453367 ENSP00000440508 ENSP00000380265 ENSP00000380264

ENSP00000453983 ENSP00000452645 ENSP00000454099 ENSP00000404147 ENSP00000380263

ENSP00000311993 ENSP00000372209

DHRS4 Human Recombinant Protein Products:

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	Novus Biologicals DHRS4 Proteins Novus Biologicals DHRS4 Lysates
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	ProSpec Recombinant Protein for DHRS4
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DHRS4 Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	Cloud-Clone Corp. ELISAs for DHRS4 Cloud-Clone Corp. CLIAs for DHRS4

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

SDRC1: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 1

4 InterPro protein domains:

IPR020904 Sc_DH/Rdtase_CS

IPR002347 Glc/ribitol_DH

IPR002198 DH_sc/Rdtase_SDR

IPR016040 NAD(P)-bd_dom

Graphical View of Domain Structure for InterPro Entry Q9BTZ2

ProtoNet protein and cluster: Q9BTZ2

2 Blocks protein domains:

IPB002198 Short-chain dehydrogenase/reductase SDR

IPB002347 Glucose/ribitol dehydrogenase family signature

UniProtKB/Swiss-Prot: DHRS4_HUMAN, Q9BTZ2

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family

DHRS4 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: DHRS4_HUMAN, Q9BTZ2

Function: Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with

NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds

with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and

4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity)

Catalytic activity: R-CHOH-R' + NADP(+) = R-CO-R' + NADPH

Enzyme Numbers (IUBMB): EC 1.1.1.184¹ ² EC 1.1.1²

Gene Ontology (GO): Selected molecular function terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000253	3-keto sterol reductase activity	IDA	18571493
GO:0004090	carbonyl reductase (NADPH) activity	IDA	18571493
GO:0005102	receptor binding	IPI	--
GO:0016491	oxidoreductase activity	--	--
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IDA	19442656

DHRS4 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for DHRS4:

G0/1 arrest

Increased G1 DNA content

Increased gamma-H2AX phosphory

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dhrs4):

behavior/neurological

hematopoietic system

immune system

DHRS4 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Dhrs4^tm1Lex for DHRS4

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DHRS4

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DHRS4

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DHRS4

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DHRS4

miRNA Products:		miRTarBase miRNAs that target DHRS4: hsa-mir-181d-5p (MIRT041172)

		Block miRNA regulation of human, mouse, rat DHRS4 using miScript Target Protectors
		5 qRT-PCR Assays for microRNAs that regulate DHRS4:
		hsa-miR-214 hsa-miR-1266 hsa-miR-761 hsa-miR-3153 hsa-miR-4257
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for DHRS4
		Predesigned siRNA for gene silencing in human, mouse, rat DHRS4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for DHRS4

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		GenScript: all cDNA clones in your preferred vector: DHRS4 (NM_021004)
		Sino Biological Human cDNA Clone for DHRS4
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		Browse ESI BIO Cell Lines and PureStem Progenitors for DHRS4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHRS4

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

DHRS4_HUMAN, Q9BTZ2: Peroxisome. Note=Isoform 1 is peroxisomal, while isoform 4 is not

DHRS4_HUMAN, Q9BTZ2: Isoform 7: Nucleus

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5
peroxisome	5
mitochondrion	4
cytosol	2

About this image

Gene Ontology (GO): Selected cellular component terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005739	mitochondrion	ISS	--
GO:0005777	peroxisome	IDA	17230527
GO:0005778	peroxisomal membrane	IDA	10333503
GO:0031965	nuclear membrane	IDA	--

DHRS4 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for DHRS4 About (see all 6)

See pathways by source

SuperPath

Contained pathways About

the visual cycle I (vertebrates)

the visual cycle I (vertebrates)

0.52

retinol biosynthesis

0.52

Metabolism

Metabolic pathways

0.38

Chemical carcinogenesis

Retinol metabolism

0.35

Retinol metabolism

Retinol metabolism

Prostaglandin 2 biosynthesis and metabolism FM

Prostaglandin 2 biosynthesis and metabolism FM

Pathways by source See SuperPaths
Show all pathways

2 GeneGo (Thomson Reuters) Pathways for DHRS4

	Retinol metabolism
	Prostaglandin 2 biosynthesis and metabolism FM

2 BioSystems Pathways for DHRS4

	retinol biosynthesis
	the visual cycle I (vertebrates)

3 Kegg Pathways (Kegg details for DHRS4):

	Retinol metabolism
	Metabolic pathways
	Peroxisome

DHRS4 for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for DHRS4
Interactions:

Search GeneGlobe Interaction Network for DHRS4

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

Selected Interacting proteins for DHRS4 (Q9BTZ2³ ENSP00000326219⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RICTOR	Q6R327³	I2D: score=1
YWHAB	P31946³	I2D: score=1
BCMO1	ENSP00000258168⁴	STRING: ENSP00000258168
DGAT1	ENSP00000332258⁴	STRING: ENSP00000332258
RETSAT	ENSP00000295802⁴	STRING: ENSP00000295802

About this table

Gene Ontology (GO): Selected biological process terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006066	alcohol metabolic process	IDA	18571493
GO:0008152	metabolic process	--	--
GO:0008202	steroid metabolic process	IDA	18571493
GO:0042180	cellular ketone metabolic process	IDA	18571493
GO:0051262	protein tetramerization	IDA	18571493

DHRS4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for DHRS4

10 HMDB Compounds for DHRS4 About this table

Compound	Synonyms	CAS #	PubMed Ids
10,11-dihydro-12-oxo-LTB4	12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoic acid anion (see all 4)	--	--
10,11-dihydro-leukotriene B4	10,11-dihydro-LTB(,4) (see all 6)	--	--
12-Oxo-20-carboxy-leukotriene B4	12-oxo-20-COOH-leukotriene B(,4) (see all 5)	--	--
12-oxo-10,11-dihydro-20-COOH-LTB4	12-oxo-10,11-dihydro-20-carboxy-LTB(,4) (see all 3)	--	--
20-COOH-10,11-dihydro-LTB4	10,11-dihydro-20-COOH-leukotriene B(,4);20-carboxy-10,11-dihydro-LTB(,4);(5S,12R)-dihydroxy-(6Z,8E,14Z)-eicosatrien-1,20-dicarboxylic acid anion	--	--
Genistein	4',5, 7-Trihydroxyisoflavone (see all 11)	446-72-0	--
Menadione	Vitamin K3: 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene (see all 49)	58-27-5	--
Myristic acid	1-Tridecanecarboxylate (see all 15)	544-63-8	--
NADP	Adenine-nicotinamide dinucleotide phosphate (see all 18)	53-59-8	--
NADPH	2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)	53-57-6	--

1 DrugBank Compound for DHRS4 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Vitamin A	[11,12-3H]-Retinol (see all 18)	68-26-8	target	--	17534402

4 Novoseek inferred chemical compound relationships for DHRS4 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
4-benzoylpyridine	92.6	1	9485526 (1)
vitamin a	54.8	3	17534402 (2), 15968981 (1)
nadph	43.2	1	11306100 (1)
lipid	0	3	15476404 (1), 16406002 (1)

DHRS4 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for DHRS4 gene (6 alternative transcripts):

NM_001282987.1 NM_001282988.1 NM_001282989.1 NM_001282990.1 NM_001282991.1 NM_021004.3

Unigene Cluster for DHRS4:

Dehydrogenase/reductase (SDR family) member 4

Hs.528385 [show with all ESTs]

Unigene Representative Sequence: BM919053

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000313250(uc001wlb.3 uc010akz.3 uc001wla.3 uc001wlc.4)

ENST00000558263 ENST00000543741(uc010aky.2) ENST00000397075 ENST00000397074

ENST00000559632 ENST00000558581 ENST00000559975 ENST00000421831 ENST00000397073

ENST00000308178 ENST00000382761

miRNA Products:		Block miRNA regulation of human, mouse, rat DHRS4 using miScript Target Protectors
		5 qRT-PCR Assays for microRNAs that regulate DHRS4:
		hsa-miR-214 hsa-miR-1266 hsa-miR-761 hsa-miR-3153 hsa-miR-4257
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for DHRS4
		Predesigned siRNA for gene silencing in human, mouse, rat DHRS4

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		GenScript: all cDNA clones in your preferred vector: DHRS4 (NM_021004)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHRS4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHRS4

Primer Products:		OriGene qPCR primer pairs and template standards for DHRS4 OriGene qSTAR qPCR primer pairs in human, mouse for DHRS4
		Search Pre-validated RT² qPCR Primer Assays in human, mouse, rat DHRS4
		QuantiTect SYBR Green Assays in human, mouse, rat DHRS4
		QuantiFast Probe-based Assays in human, mouse, rat DHRS4

Additional mRNA sequence:

AB045131.1 AF044127.1 AF064256.1 AK001870.1 AK301201.1 AK308436.1 AK314448.1 AY071856.1

AY358638.1 AY616182.1 BC003019.1 DQ325464.1 DQ338571.1 DQ344810.1

22 DOTS entries:

DT.447164 DT.100800245 DT.95123574 DT.97848362 DT.120789282 DT.97848363 DT.100825829 DT.120789268

DT.120789295 DT.95104521 DT.100825822 DT.95123573 DT.97848359 DT.102828556 DT.120789286 DT.120789294

DT.40241759 DT.91748429 DT.100825824 DT.120789255 DT.120789311 DT.438606

Selected AceView cDNA sequences (see all 336):

BX117130 CB121780 BQ030242 BG696620 AI299098 CB128085 BI057123 BM802689

BX474012 BE274802 CA435002 BM709545 BX283829 AI635433 AA738454 BF939545

CB161803 CB117210 BU181392 AI202407 BU529016 BE349176 AA774916 AI673592

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for DHRS4 (see all 11) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	^	9	^	10	^	11a	·	11b	·	11c
SP1:									-				-		-				-				-		-										-
SP2:									-				-		-				-				-		-
SP3:									-				-		-				-		-		-		-		-								-
SP4:									-				-		-				-		-		-		-		-		-		-				-
SP5:									-						-				-		-		-		-		-

ECgene alternative splicing isoforms for DHRS4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DHRS4 expression in normal human tissues (normalized intensities) DHRS4 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AAAGAAACCC

About this image

DHRS4 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 2) fully expand


Blood (Hematopoietic System)
Monocytes Peripheral Blood

Kidney (Urinary System)

DHRS4 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

DHRS4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.528385

UniProtKB/Swiss-Prot: DHRS4_HUMAN, Q9BTZ2

Tissue specificity: Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is

expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform

6 are expressed in a few neoplastic cervical tissues

Custom PCR Arrays for DHRS4

Primer Products:		OriGene qPCR primer pairs and template standards for DHRS4 OriGene qSTAR qPCR primer pairs in human, mouse for DHRS4
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		QuantiFast Probe-based Assays in human, mouse, rat DHRS4

In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for DHRS4 gene from Selected species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dhrs4^{1 , 5}	dehydrogenase/reductase (SDR family) member 4^{1, 5}	80.34(n)¹ 80.58(a)¹		14 (28.19 cM)⁵ 28200¹ NM_001037938.2¹ NP_001033027.2¹ 55478758⁵
chicken (Gallus gallus)	Aves	DHRS4¹	dehydrogenase/reductase (SDR family) member 4	62.25(n) 57.43(a)		426247 NM_001277125.1 NP_001264054.1
lizard (Anolis carolinensis)	Reptilia	--	Uncharacterized protein	65(a)	1 → many	GL343877.1(71502-81133)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.11257²	Transcribed sequence with weak similarity to protein more	73.09(n)		CF591444.1
zebrafish (Danio rerio)	Actinopterygii	BC056583.1²	--	73.8(n)		393539 BC056583.1
fruit fly (Drosophila melanogaster)	Insecta	CG10672¹	CG10672	54.34(n) 51.32(a)		38598 NM_139689.3 NP_647946.1
worm (Caenorhabditis elegans)	Secernentea	dhs-13¹	dhs-13	52.88(n) 50.6(a)		178658 NM_071100.1 NP_503501.1
thale cress (Arabidopsis thaliana)	eudicotyledons	IBR1¹	IBR1	53.31(n) 50.79(a)		825905 NM_116791.2 NP_567300.1
rice (Oryza sativa)	Liliopsida	Os.8274²	Oryza sativa (japonica cultivar-group) cDNA clone0 more	72.36(n)		AK109426.1

ENSEMBL Gene Tree for DHRS4 (if available)
TreeFam Gene Tree for DHRS4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for DHRS4 gene

HPGD² DCXR² DECR2² CBR4² PECR² HSD17B14² DHRS2² HSD17B10²

BDH2² DHRS4L2² HSD17B8² DECR1²

8 SIMAP similar genes for DHRS4 using alignment to 6 protein entries: DHRS4_HUMAN (see all proteins):

DHRS4L2 DHRS2 DHRSX DHRS4L1 CBR4 BDH2

DCXR HSD17B8

DHRS4 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for DHRS4
PGOHUM00000262043

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112944764^1,2	C	--	24426320(+)	`CTGTCG/CTCCAG`	1	--	int¹		1		WA	2
rs188682789^1,2		--	24426385(+)	`GAAACA/GAACCA`	1	--	int¹		0	--	--	--	--
rs147987803^1,2		--	24426446(+)	`ACTCTC/GAAGTA`	1	--	int¹		0	--	--	--	--
rs150917745^1,2	C	--	24426529(+)	`GCCAC-/ATGTTAC`	1	--	int¹		0	--	--	--	--
rs181120990^1,2		--	24426572(+)	`TGGATA/GCTACC`	1	--	int¹		0	--	--	--	--
rs116454788^1,2	C,F	--	24426576(+)	`TACTAC/TCCAGT`	1	--	int¹		2		WA EA	238
rs145219936^1,2	C	--	24426596(+)	`ATCTG-/GACACCA`	1	--	int¹		0	--	--	--	--
rs142209008^1,2		--	24426653(+)	`TATCTC/GCTTGA`	1	--	int¹		0	--	--	--	--
rs115690102^1,2	F	--	24426738(+)	`CACACA/GATTTA`	1	--	int¹		1		WA	118
rs66683150^1,2	C	--	24426765(+)	`ACTTT-/CCTTTT`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DHRS4 (24422795 - 24438488 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for DHRS4 (see all 12): About this table

Variant ID	Type	Subtype	PubMed ID
esv2748487	CNV	Deletion	23290073
esv2421714	CNV	Deletion	20811451
nsv1218	CNV	Insertion	18451855
nsv509528	CNV	Insertion	20534489
nsv89	CNV	Loss	15895083
esv33403	CNV	Loss	17666407
esv27040	CNV	Loss	19812545
nsv9124	CNV	Loss	18304495
dgv1854n71	CNV	Loss	21882294
nsv1217	CNV	Loss	18451855

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 611596 OMIM disorders: --

8 diseases for DHRS4: About MalaCards

estrogen-receptor positive breast cancer retinitis tuberculosis hepatocellular carcinoma

cervicitis malaria breast cancer endotheliitis

DHRS4 for disorders About GeneDecksing

Genetic Association Database (GAD): DHRS4
Human Genome Epidemiology (HuGE) Navigator: DHRS4 (1 document)

Export disorders for DHRS4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DHRS4 gene, integrated from 10 sources (see all 39):
(articles sorted by number of sources associating them with DHRS4)

Utopia: connect your pdf to the dynamic
world of online information

Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase. (PubMed id 10333503)^{1, 2, 3} Fransen M.... Subramani S. (Biochem. J. 1999)
Human NRDRB1, an alternatively spliced isoform of NADP(H)-dependent retinol dehydrogenase/reductase enhanced enzymatic activity of Benzil. (PubMed id 23128527)^{1, 2} Yan Y.... Huang D. (Cell. Physiol. Biochem. 2012)
Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)^{1, 4} Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)^{1, 3} Persson B.... Oppermann U. (Chem. Biol. Interact. 2009)
Expression of a novel alternatively spliced variant of NADP(H)- dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma. (PubMed id 17230527)^{1, 2} Song X.-H.... Huang D.-Y. (Int. J. Cancer 2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
cDNA cloning of a short isoform of human liver NADP (H) -dependent retinol dehydrogenase/reductase and analysis of its characteristics. (PubMed id 15473316)^{1, 2} Du J.... Zhu L. (Yi Chuan Xue Bao 2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (Genome Res. 2003)
Molecular determinants for the stereospecific reduction of 3-ketosteroids and reactivity towards all-trans-retinal of a short-chain dehydrogenase/reductase (DHRS4). (PubMed id 19056333)^{1, 9} Endo S....Hara A. (Arch. Biochem. Biophys. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10901	HGNC: 16985	AceView: DHRS4andDHRS4L2andLOC400197	Ensembl:ENSG00000157326	euGenes: HUgn10901
ECgene: DHRS4	Kegg: 10901	H-InvDB: DHRS4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DHRS4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DHRS4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DHRS4 gene:
Search GeneIP for patents involving DHRS4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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DHRS4 Gene

Dehydrogenase/Reductase (SDR Family) Member 4

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DHRS4 (Gene Symbol)
Dehydrogenase/Reductase (SDR Family) Member 4
NRDR
Peroxisomal Short-Chain Alcohol Dehydrogenase
Short-Chain Dehydrogenase/Reductase Family Member 4
CR
PHCR
PSCD
SCAD-SRL
NADPH-Dependent Carbonyl Reductase/NADP-Retinol Dehydrogenase
NADPH-Dependent Retinol Dehydrogenase/Reductase
EC 1.1.1.184
Member 2
Short Chain Dehydrogenase/Reductase Family 25C
SDR-SRL
SDR25C1
SDR25C2
Dehydrogenase/Reductase (SDR Family) Member 4 Like 2A
Dehydrogenase/Reductase SDR Family Member 4
Short Chain Dehydrogenase/Reductase Family 25C, Member 1
Short Chain Dehydrogenase/Reductase Family 25C, Member 2
humNRDR
EC 1.1.1

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DHRS4 Gene

Dehydrogenase/Reductase (SDR Family) Member 4

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