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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DHRS4 Gene

protein-coding   GIFtS: 63
GCID: GC14P024422

Dehydrogenase/Reductase (SDR Family) Member 4
  7 related diseases
at
MalaCards
 

Aliases
for DHRS4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Dehydrogenase/Reductase (SDR Family) Member 41 2     Member 21
NRDR2 3 5     Short Chain Dehydrogenase/Reductase Family 25C1
Peroxisomal Short-Chain Alcohol Dehydrogenase2 3     SDR-SRL2
Short-Chain Dehydrogenase/Reductase Family Member 42 3     SDR25C12
CR2 3     SDR25C22
PHCR2 3     Dehydrogenase/Reductase (SDR Family) Member 4 Like 2A2
PSCD2 3     Dehydrogenase/Reductase SDR Family Member 42
SCAD-SRL2 3     Short Chain Dehydrogenase/Reductase Family 25C, Member 12
NADPH-Dependent Carbonyl Reductase/NADP-Retinol Dehydrogenase2 3     Short Chain Dehydrogenase/Reductase Family 25C, Member 22
NADPH-Dependent Retinol Dehydrogenase/Reductase2 3     humNRDR3
EC 1.1.1.1843 8     EC 1.1.18

External Ids:    HGNC: 169851   Entrez Gene: 109012   Ensembl: ENSG000001573267   OMIM: 6115965   UniProtKB: Q9BTZ23   

Export aliases for DHRS4 gene to outside databases

Previous GC identifers: GC14P018210 GC14P022413 GC14P023492 GC14P004539


Summaries
for DHRS4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for DHRS4 Gene: 
DHRS4 (dehydrogenase/reductase (SDR family) member 4) is a protein-coding gene. Diseases associated with DHRS4 include alcoholism, and estrogen-receptor positive breast cancer, and among its related super-pathways are retinol biosynthesis and Retinol metabolism. GO annotations related to this gene include oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor and nucleotide binding. An important paralog of this gene is HPGD.

UniProtKB/Swiss-Prot: DHRS4_HUMAN, Q9BTZ2
Function: Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP
as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with
aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine.
Has no activity towards aliphatic aldehydes and ketones (By similarity)

Gene Wiki entry for DHRS4 Gene


Genomic Views
for DHRS4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DHRS4 gene promoter:
         HEN1   SRF   SRF (504 AA)   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for DHRS4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHRS4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

DHRS4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHRS4 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P024422:  view genomic region     (about GC identifiers)

Start:
 24,422,795 bp from pter      End:
 24,438,488 bp from pter
Size:
 15,694 bases      Orientation:
 plus strand

Proteins
for DHRS4 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: DHRS4_HUMAN, Q9BTZ2 (See protein sequence)
Recommended Name: Dehydrogenase/reductase SDR family member 4  
Size: 278 amino acids; 29537 Da
Subunit: Homotetramer (By similarity)
Subcellular location: Peroxisome. Note=Isoform 1 is peroxisomal, while isoform 4 is not
Subcellular location: Isoform 7: Nucleus
Miscellaneous: Inhibited by kaempferol, quercetin, genistein and myristic acid (By similarity)
Sequence caution: Sequence=AAD02292.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAL61824.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB18775.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG37057.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for DHRS4:
3O4R (3D)    
Secondary accessions: B2RB10 B7WNS9 D3YTB8 E2QRL8 O95162 Q20CR0 Q2LC19 Q2LE81 Q58IU4 Q6E0Y1 Q6UWU3
Q71UQ6 Q8TD03 Q9H3N5 Q9NV08
Alternative splicing: 8 isoforms:  Q9BTZ2-1   Q9BTZ2-2   Q9BTZ2-3   Q9BTZ2-4   Q9BTZ2-5   Q9BTZ2-6   Q9BTZ2-7   Q9BTZ2-8   
(Enhanced dicarbonyl reductase activity. high expression in liver)

Explore the universe of human proteins at neXtProt for DHRS4: NX_Q9BTZ2

Explore proteomics data for DHRS4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BTZ2

    • 4/8 DME Specific Peptides for DHRS4 (Q9BTZ2) (see all 8)
     TEEVWDK  NKVALVT  APGLIKT  SSRKQQNVD 

    DHRS4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DHRS4 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001269916.1  NP_001269917.1  NP_001269918.1  NP_001269919.1  NP_001269920.1  NP_066284.2  

    ENSEMBL proteins: 
     ENSP00000326219   ENSP00000453367   ENSP00000440508   ENSP00000380265   ENSP00000380264  
     ENSP00000453983   ENSP00000452645   ENSP00000454099   ENSP00000404147   ENSP00000380263  
     ENSP00000311993   ENSP00000372209  

    Human Recombinant Protein Products for DHRS4: 
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    OriGene Protein Over-expression Lysate for DHRS4
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    Novus Biologicals DHRS4 Proteins
    Novus Biologicals DHRS4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for DHRS4
    Cloud-Clone Corp. Proteins for DHRS4 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005739mitochondrion ISS--
    GO:0005777peroxisome IDA17230527
    GO:0005778peroxisomal membrane IDA10333503

    DHRS4 for ontologies           About GeneDecksing



    DHRS4 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for DHRS4 
    Cloud-Clone Corp. CLIAs for DHRS4

    Protein Domains /
    Families
    for DHRS4 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    SDRC1: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 1

    5 InterPro protein domains:
     IPR020904 Sc_DH/Rdtase_CS
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom
     IPR027052 DHRS2/4

    Graphical View of Domain Structure for InterPro Entry Q9BTZ2

    ProtoNet protein and cluster: Q9BTZ2

    2 Blocks protein domains:
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature


    UniProtKB/Swiss-Prot: DHRS4_HUMAN, Q9BTZ2
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    DHRS4 for domains           About GeneDecksing


    Function
    for DHRS4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DHRS4_HUMAN, Q9BTZ2
    Function: Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP
    as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with
    aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine.
    Has no activity towards aliphatic aldehydes and ketones (By similarity)
    Catalytic activity: R-CHOH-R' + NADP(+) = R-CO-R' + NADPH

         Enzyme Numbers (IUBMB): EC 1.1.1.1841 2 EC 1.1.12

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00002533-keto sterol reductase activity IDA18571493
    GO:0004090carbonyl reductase (NADPH) activity IDA18571493
    GO:0005102receptor binding IPI--
    GO:0016491oxidoreductase activity ----
    GO:0016655oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA19442656
         
    DHRS4 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for DHRS4:
     G0/1 arrest  Increased G1 DNA content  Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dhrs4):
     behavior/neurological  immune system 

    DHRS4 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Dhrs4tm1Lex for DHRS4
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DHRS4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DHRS4

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DHRS4
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate DHRS4:
    hsa-miR-214 hsa-miR-1266 hsa-miR-761 hsa-miR-3153 hsa-miR-4257
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DHRS4
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    Sirion Biotech Custom design and validation of potent shRNA sequences against DHRS4

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of DHRS4
                         Customized adenovirus for potent knockdown of DHRS4

    Clone
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    OriGene ORF clones in mouse, rat for DHRS4
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    GenScript: all cDNA clones in your preferred vector: DHRS4 (NM_021004)
    Sino Biological Human cDNA Clone for DHRS4
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHRS4

    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHRS4


    Pathways & Interactions
    for DHRS4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DHRS4 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1the visual cycle I (vertebrates)
    		the visual cycle I (vertebrates)0.52
    		retinol biosynthesis0.52
    2Retinol metabolism
    		Retinol metabolism0.95
    3Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
    		Prostaglandin 2 biosynthesis and metabolism FM0.42
    4Metabolism
    		Metabolic pathways0.40
    5Drug metabolism - cytochrome P450
    		Retinol metabolism0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for DHRS4
        Prostaglandin 2 biosynthesis and metabolism FM
    Retinol metabolism


    2 GeneGo (Thomson Reuters) Pathways for DHRS4
        Retinol metabolism
    Prostaglandin 2 biosynthesis and metabolism FM

    2 BioSystems Pathways for DHRS4
        retinol biosynthesis
    the visual cycle I (vertebrates)



    3         Kegg Pathways  (Kegg details for DHRS4):
        Retinol metabolism
    Metabolic pathways
    Peroxisome


    DHRS4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DHRS4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/11 Interacting proteins for DHRS4 (Q9BTZ23 ENSP000003262194) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RICTORQ6R3273I2D: score=1 
    YWHABP319463I2D: score=1 
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    ALDH1A2ENSP000002497504STRING: ENSP00000249750
    BCMO1ENSP000002581684STRING: ENSP00000258168
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006066alcohol metabolic process IDA18571493
    GO:0008152metabolic process ----
    GO:0008202steroid metabolic process IDA18571493
    GO:0042180cellular ketone metabolic process IDA18571493
    GO:0051262protein tetramerization IDA18571493

    DHRS4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DHRS4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DHRS4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for DHRS4

    10 HMDB Compounds for DHRS4    About this table
    CompoundSynonyms CAS #PubMed Ids
    10,11-dihydro-12-oxo-LTB412-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoic acid anion (see all 4)----
    10,11-dihydro-leukotriene B410,11-dihydro-LTB(,4) (see all 6)----
    12-Oxo-20-carboxy-leukotriene B412-oxo-20-COOH-leukotriene B(,4) (see all 5)----
    12-oxo-10,11-dihydro-20-COOH-LTB412-oxo-10,11-dihydro-20-carboxy-LTB(,4) (see all 3)----
    20-COOH-10,11-dihydro-LTB410,11-dihydro-20-COOH-leukotriene B(,4);20-carboxy-10,11-dihydro-LTB(,4);(5S,12R)-dihydroxy-(6Z,8E,14Z)-eicosatrien-1,20-dicarboxylic acid anion ----
    Genistein4',5, 7-Trihydroxyisoflavone (see all 11)446-72-0--
    MenadioneVitamin K3: 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene (see all 49)58-27-5--
    Myristic acid1-Tridecanecarboxylate (see all 15)544-63-8--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--

    1 DrugBank Compound for DHRS4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vitamin A[11,12-3H]-Retinol (see all 18)68-26-8target--17534402

    4 Novoseek inferred chemical compound relationships for DHRS4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    4-benzoylpyridine 92.6 1 9485526 (1)
    vitamin a 54.8 3 17534402 (2), 15968981 (1)
    nadph 43.2 1 11306100 (1)
    lipid 0 3 15476404 (1), 16406002 (1)

    Search CenterWatch for drugs/clinical trials and news about DHRS4

    Transcripts
    for DHRS4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DHRS4 gene (6 alternative transcripts): 
    NM_001282987.1  NM_001282988.1  NM_001282989.1  NM_001282990.1  NM_001282991.1  NM_021004.3  

    Unigene Cluster for DHRS4:

    Dehydrogenase/reductase (SDR family) member 4
    Hs.528385  [show with all ESTs]
    Unigene Representative Sequence: BM919053
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000313250(uc001wlb.3 uc010akz.3 uc001wla.3 uc001wlc.4)
    ENST00000558263 ENST00000543741(uc010aky.2) ENST00000397075 ENST00000397074
    ENST00000559632 ENST00000558581 ENST00000559975 ENST00000421831 ENST00000397073
    ENST00000308178 ENST00000382761
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    Primer
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    Additional mRNA sequence: 

    AB045131.1 AF044127.1 AF064256.1 AK001870.1 AK301201.1 AK308436.1 AK314448.1 AY071856.1 
    AY358638.1 AY616182.1 BC003019.1 DQ325464.1 DQ338571.1 DQ344810.1 

    22 DOTS entries:

    DT.447164  DT.100800245  DT.95123574  DT.97848362  DT.120789282  DT.97848363  DT.100825829  DT.120789268 
    DT.120789295  DT.95104521  DT.100825822  DT.95123573  DT.97848359  DT.102828556  DT.120789286  DT.120789294 
    DT.40241759  DT.91748429  DT.100825824  DT.120789255  DT.120789311  DT.438606 

    24/336 AceView cDNA sequences (see all 336):

    CB117210 BX117130 CB161803 AA977092 BE741442 AA774916 BU529016 AA738454 
    BM709545 CB128085 AA262033 BU956321 CB268423 AI635433 AI202407 CN478470 
    BM802689 BP355509 NM_021004 BX283829 BQ438157 AI299098 AA953640 CD370135 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for DHRS4 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
    SP1:                          -           -     -           -           -     -                             -                     
    SP2:                          -           -     -           -           -     -                                                   
    SP3:                          -           -     -           -     -     -     -     -                       -                     
    SP4:                          -           -     -           -     -     -     -     -     -     -           -                     
    SP5:                          -                 -           -     -     -     -     -                                             


    ECgene alternative splicing isoforms for DHRS4

    Expression
    for DHRS4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DHRS4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGAAACCC
    DHRS4 Expression
    About this image


    See DHRS4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DHRS4

    SOURCE GeneReport for Unigene cluster: Hs.528385

    UniProtKB/Swiss-Prot: DHRS4_HUMAN, Q9BTZ2
    Tissue specificity: Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in
    some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform 6 are expressed
    in a few neoplastic cervical tissues

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    Orthologs
    for DHRS4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DHRS4 gene from 10/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dhrs41 , 5 dehydrogenase/reductase (SDR family) member 41, 5 80.34(n)1
    80.58(a)1    		   14 (28.19 cM)5
    282001  NM_001037938.21  NP_001033027.21 
     554787585 
    chicken
    (Gallus gallus)    		 Aves DHRS41 dehydrogenase/reductase (SDR family) member 4 59.85(n)
    53.28(a)    		   426247  XM_423910.3  XP_423910.3 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 Uncharacterized protein
    		 66(a)
    		 1 → many
    		 GL343877.1(71502-81133)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.112572 Transcribed sequence with weak similarity to protein more 73.09(n)    CF591444.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC056583.12   -- 73.8(n)   393539  BC056583.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG106721 CG10672 54.34(n)
    51.32(a)    		   38598  NM_139689.2  NP_647946.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea dhs-131 Protein DHS-13 52.88(n)
    50.6(a)    		   178658  NM_071100.1  NP_503501.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes (YKL071W)4 Putative protein of unknown function; expression induced more   --   11(305114-305884) 853792  NP_012852.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons IBR11 dehydrogenase/reductase SDR family member 4 53.66(n)
    51.22(a)    		   825905  NM_116791.2  NP_567300.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.82742 Oryza sativa (japonica cultivar-group) cDNA clone0 more 72.36(n)    AK109426.1 


    ENSEMBL Gene Tree for DHRS4 (if available)
    TreeFam Gene Tree for DHRS4 (if available)

    Paralogs
    for DHRS4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DHRS4 gene
    HPGD2  DCXR2  DECR22  CBR42  PECR2  HSD17B142  DHRS22  HSD17B102  
    BDH22  DHRS4L22  HSD17B82  DECR12  
    8 SIMAP similar genes for DHRS4 using alignment to 6 protein entries:     DHRS4_HUMAN (see all proteins):
    DHRS4L2    DHRS2    DHRSX    DHRS4L1    CBR4    BDH2
    DCXR    HSD17B8

    DHRS4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DHRS4
    PGOHUM00000262043


    Genomic Variants
    for DHRS4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/243 SNPs in DHRS4 are shown (see all 243)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    VAR_0572724
    		----see VAR_0572722 A T mis40--------
    rs1129447641,2
    		C--24426320(+) CTGTCG/CTCCAG 1 -- int11Minor allele frequency- C:0.50WA 2
    rs1886827891,2
    		--24426385(+) GAAACA/GAACCA 1 -- int10--------
    rs1479878031,2
    		--24426446(+) ACTCTC/GAAGTA 1 -- int10--------
    rs1509177451,2
    		C--24426529(+) GCCAC-/ATGTTAC 1 -- int10--------
    rs1811209901,2
    		--24426572(+) TGGATA/GCTACC 1 -- int10--------
    rs1164547881,2
    		C,F--24426576(+) TACTAC/TCCAGT 1 -- int12Minor allele frequency- T:0.08WA EA 238
    rs1452199361,2
    		C--24426596(+) ATCTG-/GACACCA 1 -- int10--------
    rs1422090081,2
    		--24426653(+) TATCTC/GCTTGA 1 -- int10--------
    rs1156901021,2
    		F--24426738(+) CACACA/GATTTA 1 -- int11Minor allele frequency- G:0.07WA 118

    HapMap Linkage Disequilibrium report for DHRS4 (24422795 - 24438488 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for DHRS4 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2748487CNV Deletion23290073
    esv2421714CNV Deletion20811451
    nsv1218CNV Insertion18451855
    nsv509528CNV Insertion20534489
    nsv89CNV Loss15895083
    esv33403CNV Loss17666407
    esv27040CNV Loss19812545
    nsv9124CNV Loss18304495
    dgv1854n71CNV Loss21882294
    nsv1217CNV Loss18451855

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    Disorders / Diseases
    for DHRS4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DHRS4 for disorders           About GeneDecksing

    OMIM gene information: 611596    OMIM disorders: --

    7 diseases for DHRS4:    About MalaCards
    alcoholism    estrogen-receptor positive breast cancer    tuberculosis    retinitis
    hepatocellular carcinoma    cervicitis    breast cancer

    Genetic Association Database (GAD): DHRS4
    Human Genome Epidemiology (HuGE) Navigator: DHRS4 (1 document)

    Export disorders for DHRS4 gene to outside databases

    Publications
    for DHRS4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DHRS4 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with DHRS4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase. (PubMed id 10333503)1, 2, 3 Fransen M.... Subramani S. (1999)
    2. Human NRDRB1, an alternatively spliced isoform of NADP(H)-dependent retinol dehydrogenase/reductase enhanced enzymatic activity of Benzil. (PubMed id 23128527)1, 2 Yan Y.... Huang D. (2012)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (2009)
    5. Expression of a novel alternatively spliced variant of NADP(H)- dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma. (PubMed id 17230527)1, 2 Song X.-H.... Huang D.-Y. (2007)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. CDNA cloning of a short isoform of human liver NADP (H) -dependent retinol dehydrogenase/reductase and analysis of its characteristics. (PubMed id 15473316)1, 2 Du J....Zhu L. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    10. Molecular determinants for the stereospecific reducti on of 3-ketosteroids and reactivity towards all-trans-retinal of a short-chain dehydrogenase/reductase (DHRS4). (PubMed id 19056333)1, 9 Endo S....Hara A. (2009)

    External Searches for DHRS4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DHRS4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10901 HGNC: 16985 AceView: DHRS4andDHRS4L2andLOC400197 Ensembl:ENSG00000157326 euGenes: HUgn10901
    ECgene: DHRS4 Kegg: 10901 H-InvDB: DHRS4

    Other Databases showing DHRS4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DHRS4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DHRS4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DHRS4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DHRS4 gene:
    Search GeneIP for patents involving DHRS4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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