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DHRS4 Gene(Protein Coding)

Dehydrogenase/Reductase (SDR Family) Member 4

GCID:
GC14P023953
GIFtS:
63
Genes Participants
UDN Logo

Aliases for DHRS4 Gene

Aliases for DHRS4 Gene

  • Dehydrogenase/Reductase (SDR Family) Member 4 2 3 5
  • NADPH-Dependent Carbonyl Reductase/NADP-Retinol Dehydrogenase 3 4
  • Short Chain Dehydrogenase/Reductase Family 25C Member 2 3 4
  • Short-Chain Dehydrogenase/Reductase Family Member 4 3 4
  • NADPH-Dependent Retinol Dehydrogenase/Reductase 3 4
  • Peroxisomal Short-Chain Alcohol Dehydrogenase 3 4
  • EC 1.1.1.184 4 63
  • SCAD-SRL 3 4
  • SDR25C2 3 4
  • NRDR 3 4
  • PHCR 3 4
  • PSCD 3 4
  • CR 3 4
  • Short Chain Dehydrogenase/Reductase Family 25C, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 25C, Member 2 3
  • Dehydrogenase/Reductase (SDR Family) Member 4 Like 2A 3
  • Short Chain Dehydrogenase/Reductase Family 25C 2
  • Member 2 2
  • EC 1.1.1 63
  • SDR25C1 3
  • SDR-SRL 3
  • HumNRDR 4

External Ids for DHRS4 Gene

Previous GeneCards Identifiers for DHRS4 Gene

  • GC14P018210
  • GC14P022413
  • GC14P023492
  • GC14P024422
  • GC14P004539

Summaries for DHRS4 Gene

GeneCards Summary for DHRS4 Gene

DHRS4 (Dehydrogenase/Reductase (SDR Family) Member 4) is a Protein Coding gene. Among its related pathways are Metabolism of xenobiotics by cytochrome P450 and Signaling by Retinoic Acid. GO annotations related to this gene include receptor binding and oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor. An important paralog of this gene is DECR2.

UniProtKB/Swiss-Prot for DHRS4 Gene

  • Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).

Gene Wiki entry for DHRS4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS4 Gene

Genomics for DHRS4 Gene

Products:

  1. Regulatory Element

Regulatory Elements for DHRS4 Gene

Enhancers for DHRS4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DHRS4 on UCSC Golden Path with GeneCards custom track

Promoters for DHRS4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DHRS4 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the DHRS4 gene promoter:

Genomic Location for DHRS4 Gene

Chromosome:
14
Start:
23,953,586 bp from pter
End:
23,969,279 bp from pter
Size:
15,694 bases
Orientation:
Plus strand

Genomic View for DHRS4 Gene

Genes around DHRS4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHRS4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHRS4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DHRS4 Gene

Proteins for DHRS4 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for DHRS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTZ2-DHRS4_HUMAN
    Recommended name:
    Dehydrogenase/reductase SDR family member 4
    Protein Accession:
    Q9BTZ2
    Secondary Accessions:
    • B2RB10
    • B7WNS9
    • D3YTB8
    • E2QRL8
    • O95162
    • Q20CR0
    • Q2LC19
    • Q2LE81
    • Q58IU4
    • Q6E0Y1
    • Q6UWU3
    • Q71UQ6
    • Q8TD03
    • Q9H3N5
    • Q9NV08

    Protein attributes for DHRS4 Gene

    Size:
    278 amino acids
    Molecular mass:
    29537 Da
    Quaternary structure:
    • Homotetramer.
    Miscellaneous:
    • Inhibited by kaempferol, quercetin, genistein and myristic acid.
    SequenceCaution:
    • Sequence=AAD02292.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL61824.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB18775.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG37057.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DHRS4 Gene

    Alternative splice isoforms for DHRS4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHRS4 Gene

Proteomics data for DHRS4 Gene at MOPED

Protein Expression for DHRS4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for DHRS4 Gene

Q9BTZ2:

Post-translational modifications for DHRS4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHRS4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for DHRS4 Gene

Gene Families for DHRS4 Gene

HGNC:

Protein Domains for DHRS4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DHRS4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BTZ2

UniProtKB/Swiss-Prot:

DHRS4_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS4: view

Function for DHRS4 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for DHRS4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
R-CHOH-R + NADP(+) = R-CO-R + NADPH.
UniProtKB/Swiss-Prot Function:
Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).

Enzyme Numbers (IUBMB) for DHRS4 Gene

Gene Ontology (GO) - Molecular Function for DHRS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004090 carbonyl reductase (NADPH) activity IDA 18571493
GO:0052650 NADP-retinol dehydrogenase activity TAS --
genes like me logo Genes that share ontologies with DHRS4: view

Phenotypes for DHRS4 Gene

MGI mutant phenotypes for DHRS4:
inferred from 1 alleles
GenomeRNAi human phenotypes for DHRS4:
genes like me logo Genes that share phenotypes with DHRS4: view

Animal Models for DHRS4 Gene

MGI Knock Outs for DHRS4:

Animal Model Products

  • Taconic Biosciences Mouse Models for DHRS4

miRNA for DHRS4 Gene

miRTarBase miRNAs that target DHRS4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DHRS4 Gene

Localization for DHRS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHRS4 Gene

Peroxisome. Note=Isoform 1 is peroxisomal, while isoform 4 is not.
Isoform 7: Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHRS4 Gene COMPARTMENTS Subcellular localization image for DHRS4 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
peroxisome 5
endoplasmic reticulum 4

Gene Ontology (GO) - Cellular Components for DHRS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with DHRS4: view

Pathways & Interactions for DHRS4 Gene

genes like me logo Genes that share pathways with DHRS4: view

Pathways by source for DHRS4 Gene

2 BioSystems pathways for DHRS4 Gene
3 KEGG pathways for DHRS4 Gene
2 GeneGo (Thomson Reuters) pathways for DHRS4 Gene

Gene Ontology (GO) - Biological Process for DHRS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006066 alcohol metabolic process IDA 18571493
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with DHRS4: view

No data available for SIGNOR curated interactions for DHRS4 Gene

Drugs & Compounds for DHRS4 Gene

Products:

  1. Drug

(4) Drugs for DHRS4 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin A Approved Nutra Target 438
Menadione Approved Nutra 207
MYRISTIC ACID Experimental Pharma 0
Genistein Investigational Pharma Potentiation, Activator AR agonist, EGFR kinase inhibitor. Also estrogen and PPARgamma ligand 55

(4) Additional Compounds for DHRS4 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
 53-57-6
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
 53-59-8
genes like me logo Genes that share compounds with DHRS4: view

Transcripts for DHRS4 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for DHRS4 Gene

(8) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(336) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DHRS4 Gene

Dehydrogenase/reductase (SDR family) member 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - -
SP8: - - - -
SP9: - - -
SP10: - - -
SP11: - - - - - - - - - - -

Relevant External Links for DHRS4 Gene

GeneLoc Exon Structure for
DHRS4
ECgene alternative splicing isoforms for
DHRS4

Expression for DHRS4 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for DHRS4 Gene

mRNA expression in normal human tissues for DHRS4 Gene
mRNA expression by BioGPS for DHRS4 GenemRNA expression by GTEx for DHRS4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DHRS4 Gene

This gene is overexpressed in Gallbladder (18.7), Liver (7.7), and Kidney (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHRS4 Gene



SOURCE GeneReport for Unigene cluster for DHRS4 Gene Hs.528385

mRNA Expression by UniProt/SwissProt for DHRS4 Gene

Q9BTZ2-DHRS4_HUMAN
Tissue specificity: Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform 6 are expressed in a few neoplastic cervical tissues.
genes like me logo Genes that share expression patterns with DHRS4: view

Protein tissue co-expression partners for DHRS4 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for DHRS4 Gene

Orthologs for DHRS4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHRS4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia DHRS4 35
  • 84.05 (n)
  • 81.65 (a)
DHRS4 36
  • 81 (a)
 OneToMany
dog
(Canis familiaris)
 Mammalia DHRS4 35
  • 86.69 (n)
  • 84.89 (a)
DHRS4 36
  • 84 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Dhrs4 35
  • 80.34 (n)
  • 80.58 (a)
Dhrs4 16
Dhrs4 36
  • 80 (a)
 OneToMany
chimpanzee
(Pan troglodytes)
 Mammalia DHRS4 35
  • 98.68 (n)
  • 98.2 (a)
DHRS4 36
  • 98 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Dhrs4 35
  • 80.7 (n)
  • 80.22 (a)
oppossum
(Monodelphis domestica)
 Mammalia -- 36
  • 58 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 36
  • 62 (a)
 ManyToMany
-- 36
  • 58 (a)
 ManyToMany
chicken
(Gallus gallus)
 Aves DHRS4 35
  • 62.25 (n)
  • 57.43 (a)
lizard
(Anolis carolinensis)
 Reptilia -- 36
  • 65 (a)
 OneToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia dhrs4 35
  • 62.93 (n)
  • 66.8 (a)
Str.11257 35
zebrafish
(Danio rerio)
 Actinopterygii -- 35
zgc:65987 35
  • 59.72 (n)
  • 62.16 (a)
DHRS2 36
  • 60 (a)
 OneToMany
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.4702 35
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP007475 35
  • 58.47 (n)
  • 54.84 (a)
fruit fly
(Drosophila melanogaster)
 Insecta CG10672 35
  • 54.34 (n)
  • 51.32 (a)
CG10672 36
  • 44 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea dhs-13 35
  • 52.88 (n)
  • 50.6 (a)
dhs-13 36
  • 50 (a)
 OneToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes -- 38
thale cress
(Arabidopsis thaliana)
 eudicotyledons IBR1 35
  • 53.31 (n)
  • 50.79 (a)
Alicante grape
(Vitis vinifera)
 eudicotyledons Vvi.3445 35
barley
(Hordeum vulgare)
 Liliopsida Hv.3716 35
rice
(Oryza sativa)
 Liliopsida Os.8274 35
Os09g0133200 35
  • 56.78 (n)
  • 52.03 (a)
wheat
(Triticum aestivum)
 Liliopsida Ta.3359 35
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 50 (a)
 ManyToMany
-- 36
  • 29 (a)
 ManyToMany
Species with no ortholog for DHRS4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DHRS4 Gene

ENSEMBL:
Gene Tree for DHRS4 (if available)
TreeFam:
Gene Tree for DHRS4 (if available)

Paralogs for DHRS4 Gene

Paralogs for DHRS4 Gene

(8) SIMAP similar genes for DHRS4 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for DHRS4 Gene

genes like me logo Genes that share paralogs with DHRS4: view

Variants for DHRS4 Gene

Sequence variations from dbSNP and Humsavar for DHRS4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_057272 -
rs1043650 - 23,966,355(+) TGGCC(C/T)CAAGG intron-variant, reference, missense
rs1885805 -- 23,965,870(+) GGGAC(A/C)CCACA intron-variant
rs1885806 -- 23,965,877(+) CACAC(A/G)GGCTG intron-variant
rs1885807 -- 23,965,899(+) CCACA(A/C/G)TGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHRS4 Gene

Variant ID Type Subtype PubMed ID
nsv1217 CNV Loss 18451855
nsv89 CNV Loss 15895083
nsv1218 CNV Insertion 18451855
esv27040 CNV Loss 19812545
nsv9124 CNV Loss 18304495
esv2748487 CNV Deletion 23290073
nsv509528 CNV Insertion 20534489
nsv511030 OTHER Complex 20534489
esv2421714 CNV Deletion 20811451
dgv1854n71 CNV Loss 21882294
nsv901497 CNV Gain 21882294
esv33403 CNV Loss 17666407

Variation tolerance for DHRS4 Gene

Residual Variation Intolerance Score: 96.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.04; 75.12% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DHRS4 Gene

Disorders for DHRS4 Gene

Relevant External Links for DHRS4

Genetic Association Database (GAD)
DHRS4
Human Genome Epidemiology (HuGE) Navigator
DHRS4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHRS4

No disorders were found for DHRS4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHRS4 Gene

Publications for DHRS4 Gene

  1. Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase. (PMID: 10333503) Fransen M. … Subramani S. (Biochem. J. 1999) 2 3 4 67
  2. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3
  3. Alternative transcription initiation and splicing variants of the DHRS4 gene cluster. (PMID: 18754758) Zhang Q. … Huang D. (Biosci. Rep. 2009) 3 23
  4. Molecular determinants for the stereospecific reduction of 3-ketosteroids and reactivity towards all-trans-retinal of a short-chain dehydrogenase/reductase (DHRS4). (PMID: 19056333) Endo S. … Hara A. (Arch. Biochem. Biophys. 2009) 3 23
  5. A 27.368 kDa retinal reductase in New Zealand white rabbit liver cytosol encoded by the peroxisomal retinol dehydrogenase-reductase cDNA: purification and characterization of the enzyme. (PMID: 17534402) Du K. … Huang D.Y. (Biochem. Cell Biol. 2007) 23 25

Products for DHRS4 Gene

  • Addgene plasmids for DHRS4

Sources for DHRS4 Gene

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