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Aliases for DHRS4 Gene

Aliases for DHRS4 Gene

  • Dehydrogenase/Reductase 4 2 3 5
  • NADPH-Dependent Carbonyl Reductase/NADP-Retinol Dehydrogenase 3 4
  • Short Chain Dehydrogenase/Reductase Family 25C Member 2 3 4
  • Short-Chain Dehydrogenase/Reductase Family Member 4 3 4
  • NADPH-Dependent Retinol Dehydrogenase/Reductase 3 4
  • Peroxisomal Short-Chain Alcohol Dehydrogenase 3 4
  • EC 1.1.1.184 4 61
  • SCAD-SRL 3 4
  • SDR25C2 3 4
  • NRDR 3 4
  • PHCR 3 4
  • PSCD 3 4
  • CR 3 4
  • Short Chain Dehydrogenase/Reductase Family 25C, Member 2 2
  • Short Chain Dehydrogenase/Reductase Family 25C, Member 1 3
  • Dehydrogenase/Reductase (SDR Family) Member 4 Like 2A 3
  • Dehydrogenase/Reductase (SDR Family) Member 4 2
  • Dehydrogenase/Reductase SDR Family Member 4 3
  • EC 1.1.1 61
  • SDR25C1 3
  • SDR-SRL 3
  • HumNRDR 4

External Ids for DHRS4 Gene

Previous GeneCards Identifiers for DHRS4 Gene

  • GC14P018210
  • GC14P022413
  • GC14P023492
  • GC14P024422
  • GC14P004539

Summaries for DHRS4 Gene

GeneCards Summary for DHRS4 Gene

DHRS4 (Dehydrogenase/Reductase 4) is a Protein Coding gene. Among its related pathways are Peroxisome and Signaling by GPCR. GO annotations related to this gene include receptor binding and oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor. An important paralog of this gene is DHRS4L2.

UniProtKB/Swiss-Prot for DHRS4 Gene

  • Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).

Gene Wiki entry for DHRS4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS4 Gene

Genomics for DHRS4 Gene

Regulatory Elements for DHRS4 Gene

Enhancers for DHRS4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around DHRS4 on UCSC Golden Path with GeneCards custom track

Promoters for DHRS4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for DHRS4 Gene

Chromosome:
14
Start:
23,953,586 bp from pter
End:
23,969,279 bp from pter
Size:
15,694 bases
Orientation:
Plus strand

Genomic View for DHRS4 Gene

Genes around DHRS4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHRS4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHRS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS4 Gene

Proteins for DHRS4 Gene

  • Protein details for DHRS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTZ2-DHRS4_HUMAN
    Recommended name:
    Dehydrogenase/reductase SDR family member 4
    Protein Accession:
    Q9BTZ2
    Secondary Accessions:
    • B2RB10
    • B7WNS9
    • D3YTB8
    • E2QRL8
    • O95162
    • Q20CR0
    • Q2LC19
    • Q2LE81
    • Q58IU4
    • Q6E0Y1
    • Q6UWU3
    • Q71UQ6
    • Q8TD03
    • Q9H3N5
    • Q9NV08

    Protein attributes for DHRS4 Gene

    Size:
    278 amino acids
    Molecular mass:
    29537 Da
    Quaternary structure:
    • Homotetramer.
    Miscellaneous:
    • Inhibited by kaempferol, quercetin, genistein and myristic acid.
    SequenceCaution:
    • Sequence=AAD02292.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL61824.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB18775.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG37057.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DHRS4 Gene

    Alternative splice isoforms for DHRS4 Gene

neXtProt entry for DHRS4 Gene

Post-translational modifications for DHRS4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DHRS4 Gene

Gene Families for DHRS4 Gene

Suggested Antigen Peptide Sequences for DHRS4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BTZ2

UniProtKB/Swiss-Prot:

DHRS4_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS4: view

Function for DHRS4 Gene

Molecular function for DHRS4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
R-CHOH-R + NADP(+) = R-CO-R + NADPH.
UniProtKB/Swiss-Prot Function:
Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).

Enzyme Numbers (IUBMB) for DHRS4 Gene

Gene Ontology (GO) - Molecular Function for DHRS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000253 3-keto sterol reductase activity IDA 18571493
GO:0004090 carbonyl reductase (NADPH) activity IDA 18571493
GO:0005102 receptor binding IPI 20178365
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA 19442656
GO:0018455 alcohol dehydrogenase [NAD(P)+] activity IDA 18571493
genes like me logo Genes that share ontologies with DHRS4: view
genes like me logo Genes that share phenotypes with DHRS4: view

Animal Models for DHRS4 Gene

MGI Knock Outs for DHRS4:

Animal Model Products

  • Taconic Biosciences Mouse Models for DHRS4

CRISPR Products

miRNA for DHRS4 Gene

miRTarBase miRNAs that target DHRS4

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DHRS4

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DHRS4 Gene

Localization for DHRS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHRS4 Gene

Peroxisome. Note=Isoform 1 is peroxisomal, while isoform 4 is not.
Isoform 7: Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHRS4 Gene COMPARTMENTS Subcellular localization image for DHRS4 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
peroxisome 5
endoplasmic reticulum 4

Gene Ontology (GO) - Cellular Components for DHRS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS --
GO:0005777 peroxisome IDA 17230527
GO:0005778 peroxisomal membrane IDA 10333503
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with DHRS4: view

Pathways & Interactions for DHRS4 Gene

genes like me logo Genes that share pathways with DHRS4: view

Pathways by source for DHRS4 Gene

3 KEGG pathways for DHRS4 Gene
2 GeneGo (Thomson Reuters) pathways for DHRS4 Gene

Gene Ontology (GO) - Biological Process for DHRS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006066 alcohol metabolic process IDA 18571493
GO:0008202 steroid metabolic process IDA 18571493
GO:0042180 cellular ketone metabolic process IDA 18571493
GO:0042572 retinol metabolic process IEA --
GO:0051262 protein tetramerization IDA 18571493
genes like me logo Genes that share ontologies with DHRS4: view

No data available for SIGNOR curated interactions for DHRS4 Gene

Drugs & Compounds for DHRS4 Gene

(4) Drugs for DHRS4 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin A Approved, Vet_approved Nutra Target 450
Menadione Approved Nutra 217
MYRISTIC ACID Experimental Pharma 0
Genistein Investigational Pharma Potentiation, Activator AR agonist 55

(4) Additional Compounds for DHRS4 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
genes like me logo Genes that share compounds with DHRS4: view

Transcripts for DHRS4 Gene

Unigene Clusters for DHRS4 Gene

Dehydrogenase/reductase (SDR family) member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DHRS4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - -
SP8: - - - -
SP9: - - -
SP10: - - -
SP11: - - - - - - - - - - -

Relevant External Links for DHRS4 Gene

GeneLoc Exon Structure for
DHRS4
ECgene alternative splicing isoforms for
DHRS4

Expression for DHRS4 Gene

mRNA expression in normal human tissues for DHRS4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DHRS4 Gene

This gene is overexpressed in Gallbladder (18.7), Liver (7.7), and Kidney (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DHRS4 Gene



Protein tissue co-expression partners for DHRS4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DHRS4 Gene:

DHRS4

SOURCE GeneReport for Unigene cluster for DHRS4 Gene:

Hs.528385

mRNA Expression by UniProt/SwissProt for DHRS4 Gene:

Q9BTZ2-DHRS4_HUMAN
Tissue specificity: Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform 6 are expressed in a few neoplastic cervical tissues.
genes like me logo Genes that share expression patterns with DHRS4: view

Primer Products

No data available for mRNA differential expression in normal tissues for DHRS4 Gene

Orthologs for DHRS4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHRS4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DHRS4 34
  • 84.05 (n)
  • 81.65 (a)
DHRS4 35
  • 81 (a)
OneToMany
dog
(Canis familiaris)
Mammalia DHRS4 34
  • 86.69 (n)
  • 84.89 (a)
DHRS4 35
  • 84 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Dhrs4 34
  • 80.34 (n)
  • 80.58 (a)
Dhrs4 16
Dhrs4 35
  • 80 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia DHRS4 34
  • 98.68 (n)
  • 98.2 (a)
DHRS4 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dhrs4 34
  • 80.7 (n)
  • 80.22 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 58 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 62 (a)
ManyToMany
-- 35
  • 58 (a)
ManyToMany
chicken
(Gallus gallus)
Aves DHRS4 34
  • 62.25 (n)
  • 57.43 (a)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 65 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dhrs4 34
  • 62.93 (n)
  • 66.8 (a)
Str.11257 34
zebrafish
(Danio rerio)
Actinopterygii -- 34
zgc:65987 34
  • 59.72 (n)
  • 62.16 (a)
DHRS2 35
  • 60 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4702 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007475 34
  • 58.47 (n)
  • 54.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10672 34
  • 54.34 (n)
  • 51.32 (a)
CG10672 35
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dhs-13 34
  • 52.88 (n)
  • 50.6 (a)
dhs-13 35
  • 50 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
thale cress
(Arabidopsis thaliana)
eudicotyledons IBR1 34
  • 53.31 (n)
  • 50.79 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3445 34
barley
(Hordeum vulgare)
Liliopsida Hv.3716 34
rice
(Oryza sativa)
Liliopsida Os.8274 34
Os09g0133200 34
  • 56.78 (n)
  • 52.03 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.3359 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
Species where no ortholog for DHRS4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DHRS4 Gene

ENSEMBL:
Gene Tree for DHRS4 (if available)
TreeFam:
Gene Tree for DHRS4 (if available)

Paralogs for DHRS4 Gene

(8) SIMAP similar genes for DHRS4 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for DHRS4 Gene

genes like me logo Genes that share paralogs with DHRS4: view

Variants for DHRS4 Gene

Sequence variations from dbSNP and Humsavar for DHRS4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_057272 -
rs1043650 - 23,966,355(+) TGGCC(C/T)CAAGG intron-variant, reference, missense
rs1885805 -- 23,965,870(+) GGGAC(A/C)CCACA intron-variant
rs1885806 -- 23,965,877(+) CACAC(A/G)GGCTG intron-variant
rs1885807 -- 23,965,899(+) CCACA(A/C/G)TGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHRS4 Gene

Variant ID Type Subtype PubMed ID
dgv1837n100 CNV loss 25217958
dgv1838n100 CNV gain 25217958
dgv1839n100 CNV loss 25217958
dgv1840n100 CNV gain+loss 25217958
dgv1841n100 CNV gain+loss 25217958
dgv36e203 CNV gain+loss 21179565
esv2421714 CNV deletion 20811451
esv27040 CNV loss 19812545
esv2748487 CNV deletion 23290073
esv33403 CNV loss 17666407
esv3633790 CNV loss 21293372
esv3633791 CNV gain 21293372
esv3633792 CNV loss 21293372
nsv1052180 CNV loss 25217958
nsv1217 CNV deletion 18451855
nsv1218 CNV insertion 18451855
nsv509528 CNV insertion 20534489
nsv511030 OTHER complex 20534489
nsv564046 CNV loss 21841781
nsv564047 CNV loss 21841781
nsv89 CNV deletion 15895083
nsv9124 CNV loss 18304495
nsv974316 CNV duplication 23825009
nsv983806 CNV duplication 23825009

Variation tolerance for DHRS4 Gene

Residual Variation Intolerance Score: 96.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.04; 75.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHRS4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DHRS4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHRS4 Gene

Disorders for DHRS4 Gene

Relevant External Links for DHRS4

Genetic Association Database (GAD)
DHRS4
Human Genome Epidemiology (HuGE) Navigator
DHRS4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHRS4

No disorders were found for DHRS4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHRS4 Gene

Publications for DHRS4 Gene

  1. Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase. (PMID: 10333503) Fransen M. … Subramani S. (Biochem. J. 1999) 2 3 4 65
  2. Identification of a novel isoform of DHRS4 protein with a nuclear localization signal. (PMID: 22227495) Su Z. … Huang D. (Gene 2012) 3 4 65
  3. Human NRDRB1, an alternatively spliced isoform of NADP(H)-dependent retinol dehydrogenase/reductase enhanced enzymatic activity of Benzil. (PMID: 23128527) Yan Y. … Huang D. (Cell. Physiol. Biochem. 2012) 3 4 65
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 65
  5. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3 65

Products for DHRS4 Gene

Sources for DHRS4 Gene

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