DHRS4 Gene
protein-coding GIFtS: 60
GCID: GC14P024422
|
|
dehydrogenase/reductase (SDR family) member 4
| |
Aliases
for DHRS4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dehydrogenase/Reductase (SDR Family) Member 41 2 | | NADPH-Dependent Carbonyl Reductase/NADP-Retinol Dehydrogenase2 3 | | SCAD-SRL1 2 3 | | NADPH-Dependent Retinol Dehydrogenase/Reductase2 3 | | NRDR2 3 5 | | EC 1.1.1.1843 8 | | SDR-SRL1 2 | | FLJ110081 | | SDR25C21 2 | | SDR25C12 | | HumNRDR1 | | Dehydrogenase/Reductase (SDR Family) Member 4 Like 2A2 | | Peroxisomal Short-Chain Alcohol Dehydrogenase2 3 | | Dehydrogenase/Reductase SDR Family Member 42 | | Short-Chain Dehydrogenase/Reductase Family Member 42 3 | | NADP-Dependent Retinol Dehydrogenase2 | | CR2 3 | | Short Chain Dehydrogenase/Reductase Family 25C, Member 12 | | PHCR2 3 | | Short Chain Dehydrogenase/Reductase Family 25C, Member 22 | | PSCD2 3 | | EC 1.1.18 |
Export aliases for DHRS4 gene to outside databasesPrevious GC identifers: GC14P018210 GC14P022413 GC14P023492 GC14P004539 |
Summaries
for DHRS4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: DHRS4_HUMAN, Q9BTZ2Function: Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADPas co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds witharomatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine.Has no activity towards aliphatic aldehydes and ketones (By similarity)
Gene Wiki entry for DHRS4
|
Genomic Views
for DHRS4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DHRS4 gene promoter:
HEN1 SRF SRF (504 AA) Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for DHRS4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHRS4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.2DHRS4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P024422: view genomic region
(about GC identifiers)
Start:
|
24,422,795 bp from pter |
End:
|
24,438,488 bp from pter |
Size:
|
15,694 bases |
Orientation:
|
plus strand |
|
Proteins
for DHRS4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DHRS4_HUMAN, Q9BTZ2 (See
protein sequence)Recommended Name: Dehydrogenase/reductase SDR family member 4 Size: 278 amino acids; 29537 Da
Subunit: Homotetramer (By similarity)
Subcellular location: Peroxisome. Note=Isoform 1 is peroxisomal, while isoform 4 is not
Subcellular location: Isoform 7: Nucleus
Miscellaneous: Inhibited by kaempferol, quercetin, genistein and myristic acid (By similarity)
Sequence caution: Sequence=AAD02292.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAL61824.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB18775.1;Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG37057.1; Type=Erroneous initiation;Note=Translation N-terminally extended;
1 PDB 3D structure from  and Proteopedia  for DHRS4:3O4R (3D)
Secondary accessions: B2RB10 B7WNS9 D3YTB8 E2QRL8 O95162 Q20CR0 Q2LC19 Q2LE81 Q58IU4 Q6E0Y1 Q6UWU3Q71UQ6 Q8TD03 Q9H3N5 Q9NV08Alternative splicing: 8 isoforms: Q9BTZ2-1 Q9BTZ2-2 Q9BTZ2-3 Q9BTZ2-4 Q9BTZ2-5 Q9BTZ2-6 Q9BTZ2-7 Q9BTZ2-8 (Enhanced dicarbonyl reductase activity. high expression in liver)Explore the universe of human proteins at neXtProt for DHRS4: NX_Q9BTZ2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BTZ2
4/8 DME Specific Peptides for DHRS4 (Q9BTZ2) (see all 8)
DHRS4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_066284.2
ENSEMBL proteins: ENSP00000326219 ENSP00000453367 ENSP00000440508 ENSP00000380265 ENSP00000380264 ENSP00000453983 ENSP00000452645 ENSP00000454099 ENSP00000404147 ENSP00000380263 ENSP00000311993 ENSP00000372209
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
DHRS4 for ontologies About GeneDecksing
DHRS4 Antibody Products:
Assay Products for DHRS4: |
Protein
Domains /
Families
for DHRS4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DHRS4 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BTZ2ProtoNet protein and cluster: Q9BTZ2 2 Blocks protein families: IPB002198 Short-chain dehydrogenase/reductase SDR IPB002347 Glucose/ribitol dehydrogenase family signature
UniProtKB/Swiss-Prot: DHRS4_HUMAN, Q9BTZ2Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family |
Function
for DHRS4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DHRS4_HUMAN, Q9BTZ2Function: Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADPas co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds witharomatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine.Has no activity towards aliphatic aldehydes and ketones (By similarity)Catalytic activity: R-CHOH-R' + NADP(+) = R-CO-R' + NADPHEnzyme Numbers (IUBMB): EC 1.1.1.1841 2 EC 1.1.12
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DHRS4 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DHRS4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DHRS4 (NM_021004) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DHRS4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHRS4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHRS4 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
DHRS4 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for DHRS4:
Animal Models:
Mouse knock-out Dhrs4tm1Lex for DHRS4
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Dhrs4):
DHRS4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for DHRS4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Retinol metabolism | | | 2 | the visual cycle I (vertebrates) | | | 3 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | | | 4 | Peroxisome | | | 5 | Drug metabolism - cytochrome P450 | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for DHRS4
2  GeneGo (Thomson Reuters) Pathways for DHRS4
2  BioSystems Pathways for DHRS4
3 
Kegg Pathways (Kegg details for DHRS4):
DHRS4 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DHRS4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/11 Interacting proteins for DHRS4 (Q9BTZ23 ENSP000003262194) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
DHRS4 for ontologies About GeneDecksing
|
Drugs & Compounds
for DHRS4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DHRS4 for compounds About GeneDecksing
 Browse Tocris compounds for DHRS4
10 HMDB Compounds for DHRS4 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| 10,11-dihydro-12-oxo-LTB4 | 12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoic acid anion (see all 4) | -- | -- | | 10,11-dihydro-leukotriene B4 | 10,11-dihydro-LTB(,4) (see all 6) | -- | -- | | 12-Oxo-20-carboxy-leukotriene B4 | 12-oxo-20-COOH-leukotriene B(,4) (see all 5) | -- | -- | | 12-oxo-10,11-dihydro-20-COOH-LTB4 | 12-oxo-10,11-dihydro-20-carboxy-LTB(,4) (see all 3) | -- | -- | | 20-COOH-10,11-dihydro-LTB4 | 10,11-dihydro-20-COOH-leukotriene B(,4);20-carboxy-10,11-dihydro-LTB(,4);(5S,12R)-dihydroxy-(6Z,8E,14Z)-eicosatrien-1,20-dicarboxylic acid anion | -- | -- | | Genistein | 4',5, 7-Trihydroxyisoflavone (see all 11) | 446-72-0 | -- | | Menadione | Vitamin K3: 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene (see all 49) | 58-27-5 | -- | | Myristic acid | 1-Tridecanecarboxylate (see all 15) | 544-63-8 | -- | | NADP | Adenine-nicotinamide dinucleotide phosphate (see all 18) | 53-59-8 | -- | | NADPH | 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23) | 53-57-6 | -- |
1 DrugBank Compound for DHRS4 About this table
4 Novoseek chemical compound relationships for DHRS4 gene About this table
Search CenterWatch for drugs/clinical trials and news about DHRS4
|
Transcripts
for DHRS4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DHRS4 gene: NM_021004.2 Unigene Cluster for DHRS4: Dehydrogenase/reductase (SDR family) member 4 Hs.528385 [show with all ESTs]Unigene Representative Sequence: BM91905312 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000313250(uc001wlb.3 uc010akz.3 uc001wla.3 uc001wlc.4)
ENST00000558263 ENST00000543741(uc010aky.2) ENST00000397075 ENST00000397074
ENST00000559632 ENST00000558581 ENST00000559975 ENST00000421831 ENST00000397073
ENST00000308178 ENST00000382761
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DHRS4 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DHRS4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DHRS4 (NM_021004) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DHRS4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHRS4 |
Additional cDNA sequence: AB045131.1 AF044127.1 AF064256.1 AK001870.1 AK301201.1 AK308436.1 AY071856.1 AY358638.1 AY616182.1 BC003019.1 DQ325464.1 DQ338571.1 DQ344810.1 21 DOTS entries: DT.447164 DT.100800245 DT.95123574 DT.97848362 DT.120789282 DT.97848363 DT.100825829 DT.120789268 DT.120789295 DT.95104521 DT.100825822 DT.95123573 DT.97848359 DT.102828556 DT.120789286 DT.120789294 DT.40241759 DT.91748429 DT.100825824 DT.120789255 DT.120789311 24/336 AceView cDNA sequences (see all 336): BQ438157 CD370135 BM709545 BE745939 CB140786 BU956321 BG014141 BP355509 CB110131 AI419007 CB161803 BP341298 CB142429 BG696620 CN478470 AI202407 AA774916 BQ030242 BU181392 BE349176 BG696653 CB128085 BE274802 BM802689
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for DHRS4 (see all 11) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c |
|---|
|
| SP1: | | | | | | | | | - | | | | - | | - | | | | - | | | | - | | - | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | - | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | - | | - | | | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | - | | | | - | | - | | | | - | | - | | - | | - | | - | | - | | - | | | | - | | | | | | | | |
| SP5: | | | | | | | | | - | | | | | | - | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DHRS4
|
Expression
for DHRS4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DHRS4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAGAAACCC
About this image
See DHRS4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DHRS4
SOURCE GeneReport for Unigene cluster: Hs.528385
UniProtKB/Swiss-Prot: DHRS4_HUMAN, Q9BTZ2Tissue specificity: Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed insome neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform 6 are expressedin a few neoplastic cervical tissues
SABiosciences Custom PCR Arrays for DHRS4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DHRS4
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat DHRS4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DHRS4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHRS4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHRS4 |
Orthologs
for DHRS4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DHRS4 gene from 8/31 species (see all 31) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
DHRS41 |
dehydrogenase/reductase (SDR family) member 4 |
59.85(n)
53.28(a) |
|
426247 XM_423910.3 XP_423910.3 |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
65(a) |
1 → many |
GL343877.1(71502-81133) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.112572 |
Transcribed sequence with weak similarity to protein more |
73.09(n) |
|
CF591444.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BC056583.12 |
-- |
73.8(n) |
|
393539 BC056583.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG106721 |
CG10672 |
54.34(n)
51.32(a) |
|
38598 NM_139689.2 NP_647946.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
dhs-131 |
Protein DHS-13 |
52.88(n)
50.6(a) |
|
178658 NM_071100.1 NP_503501.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
IBR11 |
dehydrogenase/reductase SDR family member 4 |
53.66(n)
51.22(a) |
|
825905 NM_116791.2 NP_567300.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.82742 |
Oryza sativa (japonica cultivar-group) cDNA clone0 more |
72.36(n) |
|
AK109426.1 |
ENSEMBL Gene Tree for DHRS4 (if available)
TreeFam Gene Tree for DHRS4 (if available) |
Paralogs
for DHRS4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DHRS4 gene
- DECR22 DCXR2 PECR2 HSD17B142 DHRS22 BDH22 DHRS4L22 DECR12
8 SIMAP similar genes for DHRS4 using alignment to 6 protein entries: DHRS4_HUMAN (see all proteins):DHRS4L2 DHRS2 DHRSX DHRS4L1 CBR4 BDH2
DCXR HSD17B8
DHRS4 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for DHRS4
PGOHUM00000262043
|
Genomic Variants
for DHRS4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DHRS4 (24422795 - 24438488 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for DHRS4
9 CNVs: 31957 35242 71871 76590 35241 7029 35240 0436 87144 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for DHRS4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DHRS4 for disorders About GeneDecksing
OMIM gene information: 611596
OMIM disorders: --
9  diseases for DHRS4: About MalaCardsestrogen-receptor positive breast cancer alcoholism hepatocellular carcinoma breast cancer
cervicitis retinitis tuberculosis carcinoma
mycobacterium tuberculosis
Human Genome Epidemiology (HuGE) Navigator: DHRS4 (1 document)
Export disorders for DHRS4 gene to outside databases
|
Publications
for DHRS4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DHRS4 gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with DHRS4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase. (PubMed id 10333503)1, 2, 3 Fransen M.... Subramani S. (1999)
- The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (2009)
- Expression of a novel alternatively spliced variant of NADP(H)- dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma. (PubMed id 17230527)1, 2 Song X.-H.... Huang D.-Y. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- CDNA cloning of a short isoform of human liver NADP (H) -dependent retinol dehydrogenase/reductase and analysis of its characteristics. (PubMed id 15473316)1, 2 Du J....Zhu L. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Molecular determinants for the stereospecific reducti on of 3-ketosteroids and reactivity towards all-trans-retinal of a short-chain dehydrogenase/reductase (DHRS4). (PubMed id 19056333)1, 9 Endo S....Hara A. (2009)
- Alternative transcription initiation and splicing variants of the DHRS4 gene cluster. (PubMed id 18754758)1, 9 Zhang Q....Huang D. (2009)
- A 27.368 kDa retinal reductase in New Zealand white r abbit liver cytosol encoded by the peroxisomal retinol dehydrogenase-reductase cDNA: purification and characterization of the enzyme. (PubMed id 17534402)7, 9 Du K....Huang D.Y. (2007)
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External Searches for DHRS4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing DHRS4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing DHRS4 gene
(According to HUGE)
About This Section
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Specialized Databases showing DHRS4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for DHRS4 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for DHRS4 gene:
Search GeneIP for patents involving DHRS4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for DHRS4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DHRS4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DHRS4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DHRS4 | | | OriGene Protein Over-expression Lysate for DHRS4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DHRS4 | | OriGene 3'-UTR Clone for DHRS4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DHRS4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DHRS4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DHRS4 | | OriGene Custom Protein Services for DHRS4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DHRS4 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DHRS4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHRS4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DHRS4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHRS4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DHRS4 |
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| | | | Search Tocris compounds for DHRS4 |
| |  |  |  |  | | | | | | Recombinant Protein for DHRS4 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHRS4 |
|  |  |  | | | | Search ThermoFisher Antibodies for DHRS4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHRS4 |
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