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DHRS4 Gene

protein-coding   GIFtS: 64
GCID: GC14P024422

Dehydrogenase/Reductase (SDR Family) Member 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dehydrogenase/Reductase (SDR Family) Member 41 2     Member 21
NRDR2 3 5     Short Chain Dehydrogenase/Reductase Family 25C1
Peroxisomal Short-Chain Alcohol Dehydrogenase2 3     SDR-SRL2
Short-Chain Dehydrogenase/Reductase Family Member 42 3     SDR25C12
CR2 3     SDR25C22
PHCR2 3     Dehydrogenase/Reductase (SDR Family) Member 4 Like 2A2
PSCD2 3     Dehydrogenase/Reductase SDR Family Member 42
SCAD-SRL2 3     Short Chain Dehydrogenase/Reductase Family 25C, Member 12
NADPH-Dependent Carbonyl Reductase/NADP-Retinol Dehydrogenase2 3     Short Chain Dehydrogenase/Reductase Family 25C, Member 22
NADPH-Dependent Retinol Dehydrogenase/Reductase2 3     humNRDR3
EC 1.1.1.1843 8     EC 1.1.18

External Ids:    HGNC: 169851   Entrez Gene: 109012   Ensembl: ENSG000001573267   OMIM: 6115965   UniProtKB: Q9BTZ23   

Export aliases for DHRS4 gene to outside databases

Previous GC identifers: GC14P018210 GC14P022413 GC14P023492 GC14P004539


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DHRS4 Gene:
DHRS4 (dehydrogenase/reductase (SDR family) member 4) is a protein-coding gene. Diseases associated with DHRS4 include estrogen-receptor positive breast cancer, and retinitis. GO annotations related to this gene include carbonyl reductase (NADPH) activity and receptor binding. An important paralog of this gene is HPGD.

UniProtKB/Swiss-Prot: DHRS4_HUMAN, Q9BTZ2
Function: Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with
NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds
with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and
4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity)

Gene Wiki entry for DHRS4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DHRS4 gene promoter:
         HEN1   SRF   SRF (504 AA)   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for DHRS4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DHRS4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

DHRS4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHRS4 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P024422:  view genomic region     (about GC identifiers)

Start:
24,422,795 bp from pter      End:
24,438,488 bp from pter
Size:
15,694 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DHRS4_HUMAN, Q9BTZ2 (See protein sequence)
Recommended Name: Dehydrogenase/reductase SDR family member 4  
Size: 278 amino acids; 29537 Da
Subunit: Homotetramer (By similarity)
Miscellaneous: Inhibited by kaempferol, quercetin, genistein and myristic acid (By similarity)
Sequence caution: Sequence=AAD02292.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAL61824.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB18775.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG37057.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for DHRS4:
3O4R (3D)    
Secondary accessions: B2RB10 B7WNS9 D3YTB8 E2QRL8 O95162 Q20CR0 Q2LC19 Q2LE81 Q58IU4 Q6E0Y1
Q6UWU3 Q71UQ6 Q8TD03 Q9H3N5 Q9NV08
Alternative splicing: 8 isoforms:  Q9BTZ2-1   Q9BTZ2-2   Q9BTZ2-3   Q9BTZ2-4   Q9BTZ2-5   Q9BTZ2-6   Q9BTZ2-7   Q9BTZ2-8   
(Enhanced dicarbonyl reductase activity. high expression in liver)

Explore the universe of human proteins at neXtProt for DHRS4: NX_Q9BTZ2

Explore proteomics data for DHRS4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DHRS4 (Q9BTZ2) (see all 8)
     TEEVWDK  NKVALVT  APGLIKT  SSRKQQNVD 


    See DHRS4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001269916.1  NP_001269917.1  NP_001269918.1  NP_001269919.1  NP_001269920.1  NP_066284.2  

    ENSEMBL proteins: 
     ENSP00000326219   ENSP00000453367   ENSP00000440508   ENSP00000380265   ENSP00000380264  
     ENSP00000453983   ENSP00000452645   ENSP00000454099   ENSP00000404147   ENSP00000380263  
     ENSP00000311993   ENSP00000372209  

    DHRS4 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for DHRS4
    OriGene Custom MassSpec
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    Novus Biologicals DHRS4 Proteins
    Novus Biologicals DHRS4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for DHRS4
    Cloud-Clone Corp. Proteins for DHRS4

    DHRS4 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for DHRS4

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    Cloud-Clone Corp. ELISAs for DHRS4
    Cloud-Clone Corp. CLIAs for DHRS4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SDRC1: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 1

    4 InterPro protein domains:
     IPR020904 Sc_DH/Rdtase_CS
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q9BTZ2

    ProtoNet protein and cluster: Q9BTZ2

    2 Blocks protein domains:
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature


    UniProtKB/Swiss-Prot: DHRS4_HUMAN, Q9BTZ2
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    DHRS4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DHRS4_HUMAN, Q9BTZ2
    Function: Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with
    NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds
    with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and
    4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity)
    Catalytic activity: R-CHOH-R' + NADP(+) = R-CO-R' + NADPH

         Enzyme Numbers (IUBMB): EC 1.1.1.1841 2 EC 1.1.12

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00002533-keto sterol reductase activity IDA18571493
    GO:0004090carbonyl reductase (NADPH) activity IDA18571493
    GO:0005102receptor binding IPI--
    GO:0016491oxidoreductase activity ----
    GO:0016655oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA19442656
         
    DHRS4 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for DHRS4:
     G0/1 arrest  Increased G1 DNA content  Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dhrs4):
     behavior/neurological  hematopoietic system  immune system 

    DHRS4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dhrs4tm1Lex for DHRS4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DHRS4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DHRS4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DHRS4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DHRS4

    miRNA
    Products:
        
    miRTarBase miRNAs that target DHRS4:
    hsa-mir-181d-5p (MIRT041172)

    Block miRNA regulation of human, mouse, rat DHRS4 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate DHRS4:
    hsa-miR-214 hsa-miR-1266 hsa-miR-761 hsa-miR-3153 hsa-miR-4257
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DHRS4
    Predesigned siRNA for gene silencing in human, mouse, rat DHRS4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DHRS4

    Clone
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    OriGene clones in human, mouse for DHRS4 (see all 8)
    OriGene ORF clones in mouse, rat for DHRS4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DHRS4 (NM_021004)
    Sino Biological Human cDNA Clone for DHRS4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHRS4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHRS4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for DHRS4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHRS4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DHRS4_HUMAN, Q9BTZ2: Peroxisome. Note=Isoform 1 is peroxisomal, while isoform 4 is not
    DHRS4_HUMAN, Q9BTZ2: Isoform 7: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    peroxisome5
    mitochondrion4
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005739mitochondrion ISS--
    GO:0005777peroxisome IDA17230527
    GO:0005778peroxisomal membrane IDA10333503
    GO:0031965nuclear membrane IDA--

    DHRS4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DHRS4 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1the visual cycle I (vertebrates)
    the visual cycle I (vertebrates)0.52
    retinol biosynthesis0.52
    2Metabolism
    Metabolic pathways0.38
    3Chemical carcinogenesis
    Retinol metabolism0.35
    4Retinol metabolism
    Retinol metabolism
    5Prostaglandin 2 biosynthesis and metabolism FM
    Prostaglandin 2 biosynthesis and metabolism FM

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for DHRS4
        Retinol metabolism
    Prostaglandin 2 biosynthesis and metabolism FM

    2 BioSystems Pathways for DHRS4
        retinol biosynthesis
    the visual cycle I (vertebrates)



    3 Kegg Pathways  (Kegg details for DHRS4):
        Retinol metabolism
    Metabolic pathways
    Peroxisome


    DHRS4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DHRS4
    Interactions:

        Search GeneGlobe Interaction Network for DHRS4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for DHRS4 (Q9BTZ23 ENSP000003262194) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RICTORQ6R3273I2D: score=1 
    YWHABP319463I2D: score=1 
    BCMO1ENSP000002581684STRING: ENSP00000258168
    DGAT1ENSP000003322584STRING: ENSP00000332258
    RETSATENSP000002958024STRING: ENSP00000295802
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006066alcohol metabolic process IDA18571493
    GO:0008152metabolic process ----
    GO:0008202steroid metabolic process IDA18571493
    GO:0042180cellular ketone metabolic process IDA18571493
    GO:0051262protein tetramerization IDA18571493

    DHRS4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DHRS4

    10 HMDB Compounds for DHRS4    About this table
    CompoundSynonyms CAS #PubMed Ids
    10,11-dihydro-12-oxo-LTB412-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoic acid anion (see all 4)----
    10,11-dihydro-leukotriene B410,11-dihydro-LTB(,4) (see all 6)----
    12-Oxo-20-carboxy-leukotriene B412-oxo-20-COOH-leukotriene B(,4) (see all 5)----
    12-oxo-10,11-dihydro-20-COOH-LTB412-oxo-10,11-dihydro-20-carboxy-LTB(,4) (see all 3)----
    20-COOH-10,11-dihydro-LTB410,11-dihydro-20-COOH-leukotriene B(,4);20-carboxy-10,11-dihydro-LTB(,4);(5S,12R)-dihydroxy-(6Z,8E,14Z)-eicosatrien-1,20-dicarboxylic acid anion ----
    Genistein4',5, 7-Trihydroxyisoflavone (see all 11)446-72-0--
    MenadioneVitamin K3: 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene (see all 49)58-27-5--
    Myristic acid1-Tridecanecarboxylate (see all 15)544-63-8--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--

    1 DrugBank Compound for DHRS4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vitamin A[11,12-3H]-Retinol (see all 18)68-26-8target--17534402

    4 Novoseek inferred chemical compound relationships for DHRS4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    4-benzoylpyridine 92.6 1 9485526 (1)
    vitamin a 54.8 3 17534402 (2), 15968981 (1)
    nadph 43.2 1 11306100 (1)
    lipid 0 3 15476404 (1), 16406002 (1)



    DHRS4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DHRS4 gene (6 alternative transcripts): 
    NM_001282987.1  NM_001282988.1  NM_001282989.1  NM_001282990.1  NM_001282991.1  NM_021004.3  

    Unigene Cluster for DHRS4:

    Dehydrogenase/reductase (SDR family) member 4
    Hs.528385  [show with all ESTs]
    Unigene Representative Sequence: BM919053
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000313250(uc001wlb.3 uc010akz.3 uc001wla.3 uc001wlc.4)
    ENST00000558263 ENST00000543741(uc010aky.2) ENST00000397075 ENST00000397074
    ENST00000559632 ENST00000558581 ENST00000559975 ENST00000421831 ENST00000397073
    ENST00000308178 ENST00000382761
    miRNA
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    hsa-miR-214 hsa-miR-1266 hsa-miR-761 hsa-miR-3153 hsa-miR-4257
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for DHRS4
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      QuantiTect SYBR Green Assays in human, mouse, rat DHRS4
      QuantiFast Probe-based Assays in human, mouse, rat DHRS4

    Additional mRNA sequence: 

    AB045131.1 AF044127.1 AF064256.1 AK001870.1 AK301201.1 AK308436.1 AK314448.1 AY071856.1 
    AY358638.1 AY616182.1 BC003019.1 DQ325464.1 DQ338571.1 DQ344810.1 

    22 DOTS entries:

    DT.447164  DT.100800245  DT.95123574  DT.97848362  DT.120789282  DT.97848363  DT.100825829  DT.120789268 
    DT.120789295  DT.95104521  DT.100825822  DT.95123573  DT.97848359  DT.102828556  DT.120789286  DT.120789294 
    DT.40241759  DT.91748429  DT.100825824  DT.120789255  DT.120789311  DT.438606 

    Selected AceView cDNA sequences (see all 336):

    BX117130 CB121780 BQ030242 BG696620 AI299098 CB128085 BI057123 BM802689 
    BX474012 BE274802 CA435002 BM709545 BX283829 AI635433 AA738454 BF939545 
    CB161803 CB117210 BU181392 AI202407 BU529016 BE349176 AA774916 AI673592 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DHRS4 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
    SP1:                          -           -     -           -           -     -                             -                     
    SP2:                          -           -     -           -           -     -                                                   
    SP3:                          -           -     -           -     -     -     -     -                       -                     
    SP4:                          -           -     -           -     -     -     -     -     -     -           -                     
    SP5:                          -                 -           -     -     -     -     -                                             


    ECgene alternative splicing isoforms for DHRS4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DHRS4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGAAACCC
    DHRS4 Expression
    About this image


    DHRS4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
     
     Kidney (Urinary System)
    DHRS4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DHRS4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.528385

    UniProtKB/Swiss-Prot: DHRS4_HUMAN, Q9BTZ2
    Tissue specificity: Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is
    expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform
    6 are expressed in a few neoplastic cervical tissues

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DHRS4 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dhrs41 , 5 dehydrogenase/reductase (SDR family) member 41, 5 80.34(n)1
    80.58(a)1
      14 (28.19 cM)5
    282001  NM_001037938.21  NP_001033027.21 
     554787585 
    chicken
    (Gallus gallus)
    Aves DHRS41 dehydrogenase/reductase (SDR family) member 4 62.25(n)
    57.43(a)
      426247  NM_001277125.1  NP_001264054.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    65(a)
    1 → many
    GL343877.1(71502-81133)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.112572 Transcribed sequence with weak similarity to protein more 73.09(n)    CF591444.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC056583.12   -- 73.8(n)   393539  BC056583.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG106721 CG10672 54.34(n)
    51.32(a)
      38598  NM_139689.3  NP_647946.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dhs-131 dhs-13 52.88(n)
    50.6(a)
      178658  NM_071100.1  NP_503501.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons IBR11 IBR1 53.31(n)
    50.79(a)
      825905  NM_116791.2  NP_567300.1 
    rice
    (Oryza sativa)
    Liliopsida Os.82742 Oryza sativa (japonica cultivar-group) cDNA clone0 more 72.36(n)    AK109426.1 


    ENSEMBL Gene Tree for DHRS4 (if available)
    TreeFam Gene Tree for DHRS4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DHRS4 gene
    HPGD2  DCXR2  DECR22  CBR42  PECR2  HSD17B142  DHRS22  HSD17B102  
    BDH22  DHRS4L22  HSD17B82  DECR12  
    8 SIMAP similar genes for DHRS4 using alignment to 6 protein entries:     DHRS4_HUMAN (see all proteins):
    DHRS4L2    DHRS2    DHRSX    DHRS4L1    CBR4    BDH2
    DCXR    HSD17B8

    DHRS4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DHRS4
    PGOHUM00000262043


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DHRS4 (see all 243)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1129447641,2
    C--24426320(+) CTGTCG/CTCCAG 1 -- int11Minor allele frequency- C:0.50WA 2
    rs1886827891,2
    --24426385(+) GAAACA/GAACCA 1 -- int10--------
    rs1479878031,2
    --24426446(+) ACTCTC/GAAGTA 1 -- int10--------
    rs1509177451,2
    C--24426529(+) GCCAC-/ATGTTAC 1 -- int10--------
    rs1811209901,2
    --24426572(+) TGGATA/GCTACC 1 -- int10--------
    rs1164547881,2
    C,F--24426576(+) TACTAC/TCCAGT 1 -- int12Minor allele frequency- T:0.08WA EA 238
    rs1452199361,2
    C--24426596(+) ATCTG-/GACACCA 1 -- int10--------
    rs1422090081,2
    --24426653(+) TATCTC/GCTTGA 1 -- int10--------
    rs1156901021,2
    F--24426738(+) CACACA/GATTTA 1 -- int11Minor allele frequency- G:0.07WA 118
    rs666831501,2
    C--24426765(+) ACTTT-/CCTTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for DHRS4 (24422795 - 24438488 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DHRS4 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2748487CNV Deletion23290073
    esv2421714CNV Deletion20811451
    nsv1218CNV Insertion18451855
    nsv509528CNV Insertion20534489
    nsv89CNV Loss15895083
    esv33403CNV Loss17666407
    esv27040CNV Loss19812545
    nsv9124CNV Loss18304495
    dgv1854n71CNV Loss21882294
    nsv1217CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611596    OMIM disorders: --

    8 diseases for DHRS4:    
    About MalaCards
    estrogen-receptor positive breast cancer    retinitis    tuberculosis    hepatocellular carcinoma
    cervicitis    malaria    breast cancer    endotheliitis


    DHRS4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DHRS4
    Human Genome Epidemiology (HuGE) Navigator: DHRS4 (1 document)

    Export disorders for DHRS4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DHRS4 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with DHRS4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase. (PubMed id 10333503)1, 2, 3 Fransen M.... Subramani S. (Biochem. J. 1999)
    2. Human NRDRB1, an alternatively spliced isoform of NADP(H)-dependent retinol dehydrogenase/reductase enhanced enzymatic activity of Benzil. (PubMed id 23128527)1, 2 Yan Y.... Huang D. (Cell. Physiol. Biochem. 2012)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (Chem. Biol. Interact. 2009)
    5. Expression of a novel alternatively spliced variant of NADP(H)- dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma. (PubMed id 17230527)1, 2 Song X.-H.... Huang D.-Y. (Int. J. Cancer 2007)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. cDNA cloning of a short isoform of human liver NADP (H) -dependent retinol dehydrogenase/reductase and analysis of its characteristics. (PubMed id 15473316)1, 2 Du J.... Zhu L. (Yi Chuan Xue Bao 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    10. Molecular determinants for the stereospecific reduction of 3-ketosteroids and reactivity towards all-trans-retinal of a short-chain dehydrogenase/reductase (DHRS4). (PubMed id 19056333)1, 9 Endo S....Hara A. (Arch. Biochem. Biophys. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10901 HGNC: 16985 AceView: DHRS4andDHRS4L2andLOC400197 Ensembl:ENSG00000157326 euGenes: HUgn10901
    ECgene: DHRS4 Kegg: 10901 H-InvDB: DHRS4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DHRS4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DHRS4 gene:
    Search GeneIP for patents involving DHRS4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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