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Aliases for DHRS4 Gene

Aliases for DHRS4 Gene

  • Dehydrogenase/Reductase (SDR Family) Member 4 2 3
  • NRDR 3 4 6
  • NADPH-Dependent Carbonyl Reductase/NADP-Retinol Dehydrogenase 3 4
  • Short Chain Dehydrogenase/Reductase Family 25C Member 2 3 4
  • Short-Chain Dehydrogenase/Reductase Family Member 4 3 4
  • NADPH-Dependent Retinol Dehydrogenase/Reductase 3 4
  • Peroxisomal Short-Chain Alcohol Dehydrogenase 3 4
  • EC 1.1.1.184 4 64
  • SCAD-SRL 3 4
  • SDR25C2 3 4
  • PHCR 3 4
  • PSCD 3 4
  • CR 3 4
  • Short Chain Dehydrogenase/Reductase Family 25C, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 25C, Member 2 3
  • Dehydrogenase/Reductase (SDR Family) Member 4 Like 2A 3
  • Short Chain Dehydrogenase/Reductase Family 25C 2
  • Dehydrogenase/Reductase SDR Family Member 4 3
  • Member 2 2
  • EC 1.1.1 64
  • SDR-SRL 3
  • SDR25C1 3
  • HumNRDR 4

External Ids for DHRS4 Gene

Summaries for DHRS4 Gene

GeneCards Summary for DHRS4 Gene

DHRS4 (Dehydrogenase/Reductase (SDR Family) Member 4) is a Protein Coding gene. Among its related pathways are Metabolism and the visual cycle I (vertebrates). GO annotations related to this gene include receptor binding and carbonyl reductase (NADPH) activity. An important paralog of this gene is DECR2.

UniProtKB/Swiss-Prot for DHRS4 Gene

  • Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).

Gene Wiki entry for DHRS4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS4 Gene

Genomics for DHRS4 Gene

Genomic Location for DHRS4 Gene

Start:
23,953,586 bp from pter
End:
23,969,279 bp from pter
Size:
15,694 bases
Orientation:
Plus strand

Genomic View for DHRS4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHRS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS4 Gene

Regulatory Elements for DHRS4 Gene

Proteins for DHRS4 Gene

  • Protein details for DHRS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTZ2-DHRS4_HUMAN
    Recommended name:
    Dehydrogenase/reductase SDR family member 4
    Protein Accession:
    Q9BTZ2
    Secondary Accessions:
    • B2RB10
    • B7WNS9
    • D3YTB8
    • E2QRL8
    • O95162
    • Q20CR0
    • Q2LC19
    • Q2LE81
    • Q58IU4
    • Q6E0Y1
    • Q6UWU3
    • Q71UQ6
    • Q8TD03
    • Q9H3N5
    • Q9NV08

    Protein attributes for DHRS4 Gene

    Size:
    278 amino acids
    Molecular mass:
    29537 Da
    Quaternary structure:
    • Homotetramer.
    Miscellaneous:
    • Inhibited by kaempferol, quercetin, genistein and myristic acid.
    SequenceCaution:
    • Sequence=AAD02292.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL61824.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB18775.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG37057.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DHRS4 Gene

    Alternative splice isoforms for DHRS4 Gene

neXtProt entry for DHRS4 Gene

Proteomics data for DHRS4 Gene at MOPED

Post-translational modifications for DHRS4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for DHRS4 Gene

Gene Families for DHRS4 Gene

HGNC:
  • SDRC1 :Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 1

UniProtKB/Swiss-Prot:

DHRS4_HUMAN
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.:
    • Q9BTZ2
genes like me logo Genes that share domains with DHRS4: view

Function for DHRS4 Gene

Molecular function for DHRS4 Gene

UniProtKB/Swiss-Prot CatalyticActivity: R-CHOH-R + NADP(+) = R-CO-R + NADPH
UniProtKB/Swiss-Prot Function: Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).

Enzyme Numbers (IUBMB) for DHRS4 Gene

Gene Ontology (GO) - Molecular Function for DHRS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000253 3-keto sterol reductase activity IDA 18571493
GO:0004090 carbonyl reductase (NADPH) activity IDA 18571493
GO:0005102 receptor binding IPI 20178365
GO:0016491 oxidoreductase activity --
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA 19442656
genes like me logo Genes that share ontologies with DHRS4: view
genes like me logo Genes that share phenotypes with DHRS4: view

Animal Models for DHRS4 Gene

MGI Knock Outs for DHRS4:

miRNA for DHRS4 Gene

miRTarBase miRNAs that target DHRS4

No data available for Transcription Factor Targeting and HOMER Transcription for DHRS4 Gene

Localization for DHRS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHRS4 Gene

Peroxisome. Note=Isoform 1 is peroxisomal, while isoform 4 is not.
Isoform 7: Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHRS4 Gene COMPARTMENTS Subcellular localization image for DHRS4 gene
Compartment Confidence
nucleus 5
peroxisome 5
mitochondrion 4
cytosol 2

Gene Ontology (GO) - Cellular Components for DHRS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22227495
GO:0005739 mitochondrion ISS --
GO:0005777 peroxisome IDA 17230527
GO:0005778 peroxisomal membrane IDA 10333503
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with DHRS4: view

Pathways for DHRS4 Gene

genes like me logo Genes that share pathways with DHRS4: view

Pathways by source for DHRS4 Gene

2 GeneGo (Thomson Reuters Life Sciences Research) pathways for DHRS4 Gene
2 BioSystems pathways for DHRS4 Gene
3 KEGG pathways for DHRS4 Gene

Gene Ontology (GO) - Biological Process for DHRS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006066 alcohol metabolic process IDA 18571493
GO:0008152 metabolic process --
GO:0008202 steroid metabolic process IDA 18571493
GO:0042180 cellular ketone metabolic process IDA 18571493
GO:0051262 protein tetramerization IDA 18571493
genes like me logo Genes that share ontologies with DHRS4: view

Compounds for DHRS4 Gene

(10) HMDB Compounds for DHRS4 Gene

Compound Synonyms Cas Number PubMed IDs
10,11-dihydro-12-oxo-LTB4
  • 12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoic acid anion
Not Available
10,11-dihydro-leukotriene B4
  • 10,11-dihydro-LTB(,4)
Not Available
12-oxo-10,11-dihydro-20-COOH-LTB4
  • 12-oxo-10,11-dihydro-20-carboxy-LTB(,4)
Not Available
12-Oxo-20-carboxy-leukotriene B4
  • 12-oxo-20-COOH-leukotriene B(,4)
Not Available
20-COOH-10,11-dihydro-LTB4
  • 10,11-dihydro-20-COOH-leukotriene B(,4)
Not Available

(1) Drugbank Compounds for DHRS4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Vitamin A
  • [11,12-3H]-Retinol
68-26-8 target

(4) Novoseek inferred chemical compound relationships for DHRS4 Gene

Compound -log(P) Hits PubMed IDs
4-benzoylpyridine 92.6 1
vitamin a 54.8 3
nadph 43.2 1
lipid 0 2
genes like me logo Genes that share compounds with DHRS4: view

Transcripts for DHRS4 Gene

Unigene Clusters for DHRS4 Gene

Dehydrogenase/reductase (SDR family) member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - -
SP8: - - - -
SP9: - - -
SP10: - - -
SP11: - - - - - - - - - - -

Relevant External Links for DHRS4 Gene

GeneLoc Exon Structure for
DHRS4
ECgene alternative splicing isoforms for
DHRS4

Expression for DHRS4 Gene

mRNA expression in normal human tissues for DHRS4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHRS4 Gene

SOURCE GeneReport for Unigene cluster for DHRS4 Gene Hs.528385

mRNA Expression by UniProt/SwissProt for DHRS4 Gene

Q9BTZ2-DHRS4_HUMAN
Tissue specificity: Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform 6 are expressed in a few neoplastic cervical tissues
genes like me logo Genes that share expressions with DHRS4: view

Orthologs for DHRS4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHRS4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHRS4 36
  • 98.68 (n)
  • 98.2 (a)
DHRS4 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DHRS4 36
  • 84.05 (n)
  • 81.65 (a)
DHRS4 37
  • 81 (a)
OneToMany
dog
(Canis familiaris)
Mammalia DHRS4 36
  • 86.69 (n)
  • 84.89 (a)
DHRS4 37
  • 84 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Dhrs4 36
  • 80.34 (n)
  • 80.58 (a)
Dhrs4 16
Dhrs4 37
  • 80 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 58 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 62 (a)
ManyToMany
-- 37
  • 58 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Dhrs4 36
  • 80.7 (n)
  • 80.22 (a)
chicken
(Gallus gallus)
Aves DHRS4 36
  • 62.25 (n)
  • 57.43 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 65 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dhrs4 36
  • 62.93 (n)
  • 66.8 (a)
Str.11257 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4702 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
DHRS2 37
  • 60 (a)
OneToMany
zgc:65987 36
  • 59.72 (n)
  • 62.16 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007475 36
  • 58.47 (n)
  • 54.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10672 36
  • 54.34 (n)
  • 51.32 (a)
CG10672 37
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dhs-13 36
  • 52.88 (n)
  • 50.6 (a)
dhs-13 37
  • 50 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 39
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3445 36
thale cress
(Arabidopsis thaliana)
eudicotyledons IBR1 36
  • 53.31 (n)
  • 50.79 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.3716 36
rice
(Oryza sativa)
Liliopsida Os.8274 36
Os09g0133200 36
  • 56.78 (n)
  • 52.03 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.3359 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 50 (a)
ManyToMany
-- 37
  • 29 (a)
ManyToMany
Species with no ortholog for DHRS4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DHRS4 Gene

ENSEMBL:
Gene Tree for DHRS4 (if available)
TreeFam:
Gene Tree for DHRS4 (if available)

Paralogs for DHRS4 Gene

Selected SIMAP similar genes for DHRS4 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for DHRS4 Gene

genes like me logo Genes that share paralogs with DHRS4: view

Variants for DHRS4 Gene

Sequence variations from dbSNP and Humsavar for DHRS4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1957687 -- 23,960,401(+) TTTAC(A/G/T)AGTTG intron-variant
rs1957688 -- 23,960,744(+) TCTGC(A/G)TTTTA intron-variant
rs2146573 -- 23,960,794(+) gaata(C/T)ctgag intron-variant
rs2146574 -- 23,960,826(+) gaagt(G/T)tgttt intron-variant
rs2181423 -- 23,960,639(+) CACAC(C/T)CTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHRS4 Gene

Variant ID Type Subtype PubMed ID
nsv1217 CNV Loss 18451855
nsv89 CNV Loss 15895083
nsv1218 CNV Insertion 18451855
esv27040 CNV Loss 19812545
nsv9124 CNV Loss 18304495
esv2748487 CNV Deletion 23290073
nsv509528 CNV Insertion 20534489
nsv511030 OTHER Complex 20534489
esv2421714 CNV Deletion 20811451
dgv1854n71 CNV Loss 21882294
nsv901497 CNV Gain 21882294
esv33403 CNV Loss 17666407

Relevant External Links for DHRS4 Gene

HapMap Linkage Disequilibrium report
DHRS4

Disorders for DHRS4 Gene

Relevant External Links for DHRS4

Genetic Association Database (GAD)
DHRS4
Human Genome Epidemiology (HuGE) Navigator
DHRS4
genes like me logo Genes that share disorders with DHRS4: view

No data available for UniProtKB/Swiss-Prot for DHRS4 Gene

Publications for DHRS4 Gene

  1. Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase. (PMID: 10333503) Fransen M. … Subramani S. (Biochem. J. 1999) 2 3 4
  2. Alternative transcription initiation and splicing variants of the DHRS4 gene cluster. (PMID: 18754758) Zhang Q. … Huang D. (Biosci. Rep. 2009) 3 23
  3. Molecular determinants for the stereospecific reduction of 3-ketosteroids and reactivity towards all-trans-retinal of a short-chain dehydrogenase/reductase (DHRS4). (PMID: 19056333) Endo S. … Hara A. (Arch. Biochem. Biophys. 2009) 3 23
  4. cDNA cloning of a short isoform of human liver NADP (H) -dependent retinol dehydrogenase/reductase and analysis of its characteristics. (PMID: 15473316) Du J. … Zhu L. (Yi Chuan Xue Bao 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for DHRS4 Gene

Sources for DHRS4 Gene

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