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Aliases for DHRS3 Gene

Aliases for DHRS3 Gene

  • Dehydrogenase/Reductase (SDR Family) Member 3 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 16C Member 1 3 4
  • Retinal Short-Chain Dehydrogenase/Reductase 1 3 4
  • Retinol Dehydrogenase 17 3 4
  • SDR16C1 3 4
  • RetSDR1 3 4
  • DD83.1 3 4
  • RDH17 3 4
  • Short Chain Dehydrogenase/Reductase Family 16C, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 16C 2
  • Short-Chain Dehydrogenase/Reductase 1 3
  • Dehydrogenase/Reductase Member 3 3
  • EC 1.1.1.300 4
  • Member 1 2
  • EC 1.1.1 63
  • Rsdr1 3
  • SDR1 3

External Ids for DHRS3 Gene

Previous GeneCards Identifiers for DHRS3 Gene

  • GC01M012309
  • GC01M012562
  • GC01M012550
  • GC01M012627
  • GC01M011781

Summaries for DHRS3 Gene

Entrez Gene Summary for DHRS3 Gene

  • Short-chain dehydrogenases/reductases (SDRs), such as DHRS3, catalyze the oxidation/reduction of a wide range of substrates, including retinoids and steroids (Haeseleer and Palczewski, 2000 [PubMed 10800688]).[supplied by OMIM, Jun 2009]

GeneCards Summary for DHRS3 Gene

DHRS3 (Dehydrogenase/Reductase (SDR Family) Member 3) is a Protein Coding gene. Diseases associated with DHRS3 include Neuroblastoma. Among its related pathways are Metabolism of xenobiotics by cytochrome P450 and Signaling by Retinoic Acid. GO annotations related to this gene include nucleotide binding and electron carrier activity. An important paralog of this gene is RDH10.

UniProtKB/Swiss-Prot for DHRS3 Gene

  • Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.

Gene Wiki entry for DHRS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS3 Gene

Genomics for DHRS3 Gene

Regulatory Elements for DHRS3 Gene

Enhancers for DHRS3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DHRS3 on UCSC Golden Path with GeneCards custom track

Promoters for DHRS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DHRS3 on UCSC Golden Path with GeneCards custom track

Genomic Location for DHRS3 Gene

Chromosome:
1
Start:
12,567,910 bp from pter
End:
12,618,361 bp from pter
Size:
50,452 bases
Orientation:
Minus strand

Genomic View for DHRS3 Gene

Genes around DHRS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHRS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHRS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS3 Gene

Proteins for DHRS3 Gene

  • Protein details for DHRS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75911-DHRS3_HUMAN
    Recommended name:
    Short-chain dehydrogenase/reductase 3
    Protein Accession:
    O75911
    Secondary Accessions:
    • B2R7F3
    • Q5VUY3
    • Q6UY38
    • Q9BUC8

    Protein attributes for DHRS3 Gene

    Size:
    302 amino acids
    Molecular mass:
    33548 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Located in a region of chromosome 1 which is often deleted in aggressive neuroblastoma tumors.
    SequenceCaution:
    • Sequence=AAQ88460.1; Type=Frameshift; Positions=15; Evidence={ECO:0000305};

    Alternative splice isoforms for DHRS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHRS3 Gene

Proteomics data for DHRS3 Gene at MOPED

Selected DME Specific Peptides for DHRS3 Gene

Post-translational modifications for DHRS3 Gene

  • Ubiquitination at Lys 32 and Lys 156
  • Modification sites at PhosphoSitePlus

Other Protein References for DHRS3 Gene

Domains & Families for DHRS3 Gene

Gene Families for DHRS3 Gene

Suggested Antigen Peptide Sequences for DHRS3 Gene

Graphical View of Domain Structure for InterPro Entry

O75911

UniProtKB/Swiss-Prot:

DHRS3_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS3: view

Function for DHRS3 Gene

Molecular function for DHRS3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
All-trans-retinol + NADP(+) = all-trans-retinal + NADPH.
UniProtKB/Swiss-Prot Function:
Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
UniProtKB/Swiss-Prot Induction:
By retinoic acid.

Enzyme Numbers (IUBMB) for DHRS3 Gene

Gene Ontology (GO) - Molecular Function for DHRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding TAS 9705317
GO:0009055 electron carrier activity TAS 9705317
genes like me logo Genes that share ontologies with DHRS3: view
genes like me logo Genes that share phenotypes with DHRS3: view

Animal Models for DHRS3 Gene

MGI Knock Outs for DHRS3:

Animal Model Products

  • Taconic Biosciences Mouse Models for DHRS3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DHRS3 Gene

Localization for DHRS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHRS3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHRS3 Gene COMPARTMENTS Subcellular localization image for DHRS3 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
mitochondrion 2
nucleus 2
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for DHRS3 Gene

Pathways & Interactions for DHRS3 Gene

genes like me logo Genes that share pathways with DHRS3: view

Pathways by source for DHRS3 Gene

Interacting Proteins for DHRS3 Gene

Gene Ontology (GO) - Biological Process for DHRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process IEA,TAS --
GO:0003151 outflow tract morphogenesis IEA --
GO:0007603 phototransduction, visible light TAS --
GO:0008152 metabolic process IEA --
GO:0030278 regulation of ossification IEA --
genes like me logo Genes that share ontologies with DHRS3: view

No data available for SIGNOR curated interactions for DHRS3 Gene

Drugs & Compounds for DHRS3 Gene

(1) Drugs for DHRS3 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin A Approved Nutra Target 438

(3) Additional Compounds for DHRS3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
Retinal
  • 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-Nonatetraenal
  • All-E-Retinal
  • All-epsilon-Retinal
  • All-trans-Retinal
  • All-trans-Retinaldehyde
116-31-4
genes like me logo Genes that share compounds with DHRS3: view

Transcripts for DHRS3 Gene

Unigene Clusters for DHRS3 Gene

Dehydrogenase/reductase (SDR family) member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b
SP1: - - - -
SP2: -
SP3: - - - - - -
SP4: - -
SP5: - - -

Relevant External Links for DHRS3 Gene

GeneLoc Exon Structure for
DHRS3
ECgene alternative splicing isoforms for
DHRS3

Expression for DHRS3 Gene

mRNA expression in normal human tissues for DHRS3 Gene

mRNA differential expression in normal tissues according to GTEx for DHRS3 Gene

This gene is overexpressed in Liver (x4.7).

Protein differential expression in normal tissues from HIPED for DHRS3 Gene

This gene is overexpressed in Nasal epithelium (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for DHRS3 Gene



SOURCE GeneReport for Unigene cluster for DHRS3 Gene Hs.289347

mRNA Expression by UniProt/SwissProt for DHRS3 Gene

O75911-DHRS3_HUMAN
Tissue specificity: Widely expressed with highest levels found in heart, placenta, lung, liver, kidney, pancreas, thyroid, testis, stomach, trachea and spinal cord. Lower levels found in skeletal muscle, intestine and lymph node. No expression detected in brain. In the retina, expressed in cone but not rod outer segments.
genes like me logo Genes that share expression patterns with DHRS3: view

Protein tissue co-expression partners for DHRS3 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DHRS3 Gene

Orthologs for DHRS3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DHRS3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DHRS3 35
  • 94.04 (n)
  • 99.01 (a)
DHRS3 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DHRS3 35
  • 92.83 (n)
  • 98.01 (a)
DHRS3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dhrs3 35
  • 88.19 (n)
  • 95.03 (a)
Dhrs3 16
Dhrs3 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DHRS3 35
  • 99.78 (n)
  • 100 (a)
DHRS3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dhrs3 35
  • 88.74 (n)
  • 95.36 (a)
oppossum
(Monodelphis domestica)
Mammalia DHRS3 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DHRS3 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves DHRS3 35
  • 80.57 (n)
  • 90.07 (a)
DHRS3 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHRS3 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhrs3 35
  • 74.17 (n)
  • 84.11 (a)
Str.2573 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.13360 35
zebrafish
(Danio rerio)
Actinopterygii dhrs3b 35
  • 74.61 (n)
  • 78.48 (a)
wufc04h12 35
dhrs3a 36
  • 77 (a)
OneToMany
dhrs3b 36
  • 79 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5264 35
fruit fly
(Drosophila melanogaster)
Insecta CG13833 36
  • 24 (a)
ManyToMany
CG14946 36
  • 28 (a)
ManyToMany
CG15629 36
  • 31 (a)
ManyToMany
CG17121 36
  • 22 (a)
ManyToMany
CG2254 36
  • 27 (a)
ManyToMany
CG9265 36
  • 24 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dhs-29 36
  • 18 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 21 (a)
ManyToMany
TDA5 36
  • 20 (a)
ManyToMany
Species with no ortholog for DHRS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHRS3 Gene

ENSEMBL:
Gene Tree for DHRS3 (if available)
TreeFam:
Gene Tree for DHRS3 (if available)

Paralogs for DHRS3 Gene

Paralogs for DHRS3 Gene

(5) SIMAP similar genes for DHRS3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DHRS3: view

Variants for DHRS3 Gene

Sequence variations from dbSNP and Humsavar for DHRS3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1128251 - 12,617,344(-) GATGG(C/T)GTGGA upstream-variant-2KB, reference, missense
rs4580 -- 12,568,159(-) TGGGT(A/G)TAACT utr-variant-3-prime
rs15636 -- 12,606,271(+) TTCAT(C/T)TTGTT intron-variant
rs1128298 -- 12,568,064(-) TGCTT(C/T)TCAAG utr-variant-3-prime
rs1128311 -- 12,567,999(-) ATGCT(C/T)TGCCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DHRS3 Gene

Variant ID Type Subtype PubMed ID
nsv517848 CNV Gain 19592680
essv17144 CNV CNV 17122850
dgv20e1 CNV Complex 17122850
nsv521737 CNV Loss 19592680
nsv871052 CNV Loss 21882294
nsv466172 CNV Loss 19166990
nsv466283 CNV Gain 19166990
dgv145n71 CNV Gain 21882294
nsv870867 CNV Gain 21882294
dgv21e1 CNV Complex 17122850
nsv428410 CNV Gain+Loss 18775914

Variation tolerance for DHRS3 Gene

Residual Variation Intolerance Score: 82.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.29% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DHRS3 Gene

Disorders for DHRS3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DHRS3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neuroblastoma
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards
Search DHRS3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DHRS3

Genetic Association Database (GAD)
DHRS3
Human Genome Epidemiology (HuGE) Navigator
DHRS3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHRS3
genes like me logo Genes that share disorders with DHRS3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DHRS3 Gene

Publications for DHRS3 Gene

  1. Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal. (PMID: 9705317) Haeseleer F. … Palczewski K. (J. Biol. Chem. 1998) 2 3 4 23 25 67
  2. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3
  3. Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina. (PMID: 12226107) Haeseleer F. … Palczewski K. (J. Biol. Chem. 2002) 2 3
  4. retSDR1, a short-chain retinol dehydrogenase/reductase, is retinoic acid-inducible and frequently deleted in human neuroblastoma cell lines. (PMID: 11861404) Cerignoli F. … Giannini G. (Cancer Res. 2002) 3 25
  5. The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasis. (PMID: 24733397) Adams M.K. … Kedishvili N.Y. (J. Biol. Chem. 2014) 3

Products for DHRS3 Gene

Sources for DHRS3 Gene

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