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Aliases for DHRS3 Gene

Aliases for DHRS3 Gene

  • Dehydrogenase/Reductase (SDR Family) Member 3 2 3
  • RetSDR1 3 4 6
  • Short Chain Dehydrogenase/Reductase Family 16C Member 1 3 4
  • Retinal Short-Chain Dehydrogenase/Reductase 1 3 4
  • Retinol Dehydrogenase 17 3 4
  • SDR16C1 3 4
  • DD83.1 3 4
  • RDH17 3 4
  • Short Chain Dehydrogenase/Reductase Family 16C, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 16C 2
  • Short-Chain Dehydrogenase/Reductase 1 3
  • Short-Chain Dehydrogenase/Reductase 3 3
  • EC 4
  • Member 1 2
  • EC 1.1.1 63
  • Rsdr1 3
  • SDR1 3

External Ids for DHRS3 Gene

Previous GeneCards Identifiers for DHRS3 Gene

  • GC01M012309
  • GC01M012562
  • GC01M012550
  • GC01M012627
  • GC01M011781

Summaries for DHRS3 Gene

Entrez Gene Summary for DHRS3 Gene

  • Short-chain dehydrogenases/reductases (SDRs), such as DHRS3, catalyze the oxidation/reduction of a wide range of substrates, including retinoids and steroids (Haeseleer and Palczewski, 2000 [PubMed 10800688]).[supplied by OMIM, Jun 2009]

GeneCards Summary for DHRS3 Gene

DHRS3 (Dehydrogenase/Reductase (SDR Family) Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include nucleotide binding and NADP-retinol dehydrogenase activity. An important paralog of this gene is RDH10.

UniProtKB/Swiss-Prot for DHRS3 Gene

  • Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.

Gene Wiki entry for DHRS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS3 Gene

Genomics for DHRS3 Gene

Regulatory Elements for DHRS3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DHRS3 Gene

12,567,910 bp from pter
12,618,361 bp from pter
50,452 bases
Minus strand

Genomic View for DHRS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHRS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS3 Gene

Proteins for DHRS3 Gene

  • Protein details for DHRS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Short-chain dehydrogenase/reductase 3
    Protein Accession:
    Secondary Accessions:
    • B2R7F3
    • Q5VUY3
    • Q6UY38
    • Q9BUC8

    Protein attributes for DHRS3 Gene

    302 amino acids
    Molecular mass:
    33548 Da
    Quaternary structure:
    No Data Available
    • Located in a region of chromosome 1 which is often deleted in aggressive neuroblastoma tumors
    • Sequence=AAQ88460.1; Type=Frameshift; Positions=15; Evidence={ECO:0000305};

    Alternative splice isoforms for DHRS3 Gene


neXtProt entry for DHRS3 Gene

Proteomics data for DHRS3 Gene at MOPED

Selected DME Specific Peptides for DHRS3 Gene

Post-translational modifications for DHRS3 Gene

  • Ubiquitination at Lys32 and Lys156
  • Modification sites at PhosphoSitePlus

Other Protein References for DHRS3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for DHRS3 Gene

Gene Families for DHRS3 Gene

Suggested Antigen Peptide Sequences for DHRS3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS3: view

Function for DHRS3 Gene

Molecular function for DHRS3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
All-trans-retinol + NADP(+) = all-trans-retinal + NADPH
UniProtKB/Swiss-Prot Function:
Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
UniProtKB/Swiss-Prot Induction:
By retinoic acid.

Enzyme Numbers (IUBMB) for DHRS3 Gene

Gene Ontology (GO) - Molecular Function for DHRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding TAS 9705317
GO:0004745 retinol dehydrogenase activity IEA --
GO:0009055 electron carrier activity TAS 9705317
GO:0016491 oxidoreductase activity --
GO:0052650 NADP-retinol dehydrogenase activity IEA --
genes like me logo Genes that share ontologies with DHRS3: view
genes like me logo Genes that share phenotypes with DHRS3: view

Animal Models for DHRS3 Gene

MGI Knock Outs for DHRS3:

Animal Model Products

miRNA for DHRS3 Gene

miRTarBase miRNAs that target DHRS3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DHRS3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for DHRS3 Gene

Localization for DHRS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHRS3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for DHRS3 Gene COMPARTMENTS Subcellular localization image for DHRS3 gene
Compartment Confidence
plasma membrane 3
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DHRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0042622 photoreceptor outer segment membrane TAS --
genes like me logo Genes that share ontologies with DHRS3: view

Pathways for DHRS3 Gene

genes like me logo Genes that share pathways with DHRS3: view

Pathways by source for DHRS3 Gene

Interacting Proteins for DHRS3 Gene

Gene Ontology (GO) - Biological Process for DHRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0003151 outflow tract morphogenesis IEA --
GO:0007601 visual perception TAS 9705317
GO:0007603 phototransduction, visible light TAS --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with DHRS3: view

Drugs for DHRS3 Gene

(1) Drugbank Compounds for DHRS3 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
Vitamin A
  • (2e,4e,6e,8e)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ol
68-26-8 Target approved, nutraceutical

(4) HMDB Compounds for DHRS3 Gene

Compound Synonyms Cas Number PubMed IDs
  • Adenine-nicotinamide dinucleotide phosphate
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-Nonatetraenal
Vitamin A
  • (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol
genes like me logo Genes that share compounds with DHRS3: view

Transcripts for DHRS3 Gene

Unigene Clusters for DHRS3 Gene

Dehydrogenase/reductase (SDR family) member 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DHRS3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b
SP1: - - - -
SP2: -
SP3: - - - - - -
SP4: - -
SP5: - - -

Relevant External Links for DHRS3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHRS3 Gene

mRNA expression in normal human tissues for DHRS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DHRS3 Gene

This gene is overexpressed in Liver (4.7).

Protein differential expression in normal tissues for DHRS3 Gene

This gene is overexpressed in Nasal epithelium (66.5).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for DHRS3 Gene

SOURCE GeneReport for Unigene cluster for DHRS3 Gene Hs.289347

mRNA Expression by UniProt/SwissProt for DHRS3 Gene

Tissue specificity: Widely expressed with highest levels found in heart, placenta, lung, liver, kidney, pancreas, thyroid, testis, stomach, trachea and spinal cord. Lower levels found in skeletal muscle, intestine and lymph node. No expression detected in brain. In the retina, expressed in cone but not rod outer segments.
genes like me logo Genes that share expressions with DHRS3: view

Expression partners for DHRS3 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for DHRS3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DHRS3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DHRS3 35
  • 94.04 (n)
  • 99.01 (a)
DHRS3 36
  • 100 (a)
(Canis familiaris)
Mammalia DHRS3 35
  • 92.83 (n)
  • 98.01 (a)
DHRS3 36
  • 98 (a)
(Mus musculus)
Mammalia Dhrs3 35
  • 88.19 (n)
  • 95.03 (a)
Dhrs3 16
Dhrs3 36
  • 95 (a)
(Pan troglodytes)
Mammalia DHRS3 35
  • 99.78 (n)
  • 100 (a)
DHRS3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Dhrs3 35
  • 88.74 (n)
  • 95.36 (a)
(Monodelphis domestica)
Mammalia DHRS3 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia DHRS3 36
  • 93 (a)
(Gallus gallus)
Aves DHRS3 35
  • 80.57 (n)
  • 90.07 (a)
DHRS3 36
  • 90 (a)
(Anolis carolinensis)
Reptilia DHRS3 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dhrs3 35
  • 74.17 (n)
  • 84.11 (a)
Str.2573 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.13360 35
(Danio rerio)
Actinopterygii dhrs3b 35
  • 74.61 (n)
  • 78.48 (a)
wufc04h12 35
dhrs3a 36
  • 77 (a)
dhrs3b 36
  • 79 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5264 35
fruit fly
(Drosophila melanogaster)
Insecta CG13833 36
  • 24 (a)
CG14946 36
  • 28 (a)
CG15629 36
  • 31 (a)
CG17121 36
  • 22 (a)
CG2254 36
  • 27 (a)
CG9265 36
  • 24 (a)
(Caenorhabditis elegans)
Secernentea dhs-29 36
  • 18 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 21 (a)
TDA5 36
  • 20 (a)
Species with no ortholog for DHRS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHRS3 Gene

Gene Tree for DHRS3 (if available)
Gene Tree for DHRS3 (if available)

Paralogs for DHRS3 Gene

Paralogs for DHRS3 Gene

(5) SIMAP similar genes for DHRS3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DHRS3: view

Variants for DHRS3 Gene

Sequence variations from dbSNP and Humsavar for DHRS3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4580 -- 12,568,159(-) TGGGT(A/G)TAACT utr-variant-3-prime
rs15636 -- 12,606,271(+) TTCAT(C/T)TTGTT intron-variant
rs1128251 - 12,617,344(-) GATGG(C/T)GTGGA missense, reference, upstream-variant-2KB
rs1128256 -- 12,578,831(-) TCAGC(C/T)TTCGC reference, synonymous-codon, intron-variant
rs1128298 -- 12,568,064(-) TGCTT(C/T)TCAAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DHRS3 Gene

Variant ID Type Subtype PubMed ID
nsv517848 CNV Gain 19592680
essv17144 CNV CNV 17122850
dgv20e1 CNV Complex 17122850
nsv521737 CNV Loss 19592680
nsv871052 CNV Loss 21882294
nsv466172 CNV Loss 19166990
nsv466283 CNV Gain 19166990
dgv145n71 CNV Gain 21882294
nsv870867 CNV Gain 21882294
dgv21e1 CNV Complex 17122850
nsv428410 CNV Gain+Loss 18775914

Relevant External Links for DHRS3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHRS3 Gene

Disorders for DHRS3 Gene

Relevant External Links for DHRS3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for DHRS3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DHRS3 Gene

Publications for DHRS3 Gene

  1. Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal. (PMID: 9705317) Haeseleer F. … Palczewski K. (J. Biol. Chem. 1998) 2 3 4 23 25
  2. retSDR1, a short-chain retinol dehydrogenase/reductase, is retinoic acid-inducible and frequently deleted in human neuroblastoma cell lines. (PMID: 11861404) Cerignoli F. … Giannini G. (Cancer Res. 2002) 3 4 25
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for DHRS3 Gene

Sources for DHRS3 Gene

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