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Aliases for DHRS3 Gene

Aliases for DHRS3 Gene

  • Dehydrogenase/Reductase (SDR Family) Member 3 2 3
  • RetSDR1 3 4 6
  • Short Chain Dehydrogenase/Reductase Family 16C Member 1 3 4
  • Retinal Short-Chain Dehydrogenase/Reductase 1 3 4
  • Retinol Dehydrogenase 17 3 4
  • SDR16C1 3 4
  • DD83.1 3 4
  • RDH17 3 4
  • Short Chain Dehydrogenase/Reductase Family 16C, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 16C 2
  • Short-Chain Dehydrogenase/Reductase 1 3
  • Short-Chain Dehydrogenase/Reductase 3 3
  • EC 1.1.1.300 4
  • Member 1 2
  • EC 1.1.1 63
  • Rsdr1 3
  • SDR1 3

External Ids for DHRS3 Gene

Previous GeneCards Identifiers for DHRS3 Gene

  • GC01M012309
  • GC01M012562
  • GC01M012550
  • GC01M012627
  • GC01M011781

Summaries for DHRS3 Gene

Entrez Gene Summary for DHRS3 Gene

  • Short-chain dehydrogenases/reductases (SDRs), such as DHRS3, catalyze the oxidation/reduction of a wide range of substrates, including retinoids and steroids (Haeseleer and Palczewski, 2000 [PubMed 10800688]).[supplied by OMIM, Jun 2009]

GeneCards Summary for DHRS3 Gene

DHRS3 (Dehydrogenase/Reductase (SDR Family) Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include nucleotide binding and NADP-retinol dehydrogenase activity. An important paralog of this gene is RDH10.

UniProtKB/Swiss-Prot for DHRS3 Gene

  • Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.

Gene Wiki entry for DHRS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS3 Gene

Genomics for DHRS3 Gene

Regulatory Elements for DHRS3 Gene

Genomic Location for DHRS3 Gene

Start:
12,567,910 bp from pter
End:
12,618,361 bp from pter
Size:
50,452 bases
Orientation:
Minus strand

Genomic View for DHRS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHRS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS3 Gene

Proteins for DHRS3 Gene

  • Protein details for DHRS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75911-DHRS3_HUMAN
    Recommended name:
    Short-chain dehydrogenase/reductase 3
    Protein Accession:
    O75911
    Secondary Accessions:
    • B2R7F3
    • Q5VUY3
    • Q6UY38
    • Q9BUC8

    Protein attributes for DHRS3 Gene

    Size:
    302 amino acids
    Molecular mass:
    33548 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Located in a region of chromosome 1 which is often deleted in aggressive neuroblastoma tumors
    SequenceCaution:
    • Sequence=AAQ88460.1; Type=Frameshift; Positions=15; Evidence={ECO:0000305};

    Alternative splice isoforms for DHRS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHRS3 Gene

Proteomics data for DHRS3 Gene at MOPED

Selected DME Specific Peptides for DHRS3 Gene

Post-translational modifications for DHRS3 Gene

  • Ubiquitination at Lys32 and Lys156
  • Modification sites at PhosphoSitePlus

Other Protein References for DHRS3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for DHRS3 Gene

Gene Families for DHRS3 Gene

HGNC:
  • SDRC3 :Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 3

Suggested Antigen Peptide Sequences for DHRS3 Gene

Graphical View of Domain Structure for InterPro Entry

O75911

UniProtKB/Swiss-Prot:

DHRS3_HUMAN :
  • O75911
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS3: view

Function for DHRS3 Gene

Molecular function for DHRS3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: All-trans-retinol + NADP(+) = all-trans-retinal + NADPH
UniProtKB/Swiss-Prot Function: Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
UniProtKB/Swiss-Prot Induction: By retinoic acid.

Enzyme Numbers (IUBMB) for DHRS3 Gene

Gene Ontology (GO) - Molecular Function for DHRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding TAS 9705317
GO:0004745 retinol dehydrogenase activity IEA --
GO:0009055 electron carrier activity TAS 9705317
GO:0016491 oxidoreductase activity --
GO:0052650 NADP-retinol dehydrogenase activity IEA --
genes like me logo Genes that share ontologies with DHRS3: view
genes like me logo Genes that share phenotypes with DHRS3: view

Animal Models for DHRS3 Gene

MGI Knock Outs for DHRS3:

miRNA for DHRS3 Gene

miRTarBase miRNAs that target DHRS3

No data available for Transcription Factor Targeting and HOMER Transcription for DHRS3 Gene

Localization for DHRS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHRS3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHRS3 Gene COMPARTMENTS Subcellular localization image for DHRS3 gene
Compartment Confidence
plasma membrane 3
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DHRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0042622 photoreceptor outer segment membrane TAS --
genes like me logo Genes that share ontologies with DHRS3: view

Pathways for DHRS3 Gene

genes like me logo Genes that share pathways with DHRS3: view

Pathways by source for DHRS3 Gene

Interacting Proteins for DHRS3 Gene

Gene Ontology (GO) - Biological Process for DHRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0003151 outflow tract morphogenesis IEA --
GO:0007601 visual perception TAS 9705317
GO:0007603 phototransduction, visible light TAS --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with DHRS3: view

Compounds for DHRS3 Gene

(1) HMDB Compounds for DHRS3 Gene

Compound Synonyms Cas Number PubMed IDs
NADPH
  • 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
53-57-6

(1) Drugbank Compounds for DHRS3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Vitamin A
  • [11,12-3H]-Retinol
68-26-8 target
genes like me logo Genes that share compounds with DHRS3: view

Transcripts for DHRS3 Gene

Unigene Clusters for DHRS3 Gene

Dehydrogenase/reductase (SDR family) member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b
SP1: - - - -
SP2: -
SP3: - - - - - -
SP4: - -
SP5: - - -

Relevant External Links for DHRS3 Gene

GeneLoc Exon Structure for
DHRS3
ECgene alternative splicing isoforms for
DHRS3

Expression for DHRS3 Gene

mRNA expression in normal human tissues for DHRS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DHRS3 Gene

This gene is overexpressed in Liver (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for DHRS3 Gene

SOURCE GeneReport for Unigene cluster for DHRS3 Gene Hs.289347

mRNA Expression by UniProt/SwissProt for DHRS3 Gene

O75911-DHRS3_HUMAN
Tissue specificity: Widely expressed with highest levels found in heart, placenta, lung, liver, kidney, pancreas, thyroid, testis, stomach, trachea and spinal cord. Lower levels found in skeletal muscle, intestine and lymph node. No expression detected in brain. In the retina, expressed in cone but not rod outer segments.
genes like me logo Genes that share expressions with DHRS3: view

Orthologs for DHRS3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DHRS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHRS3 35
  • 99.78 (n)
  • 100 (a)
DHRS3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DHRS3 35
  • 94.04 (n)
  • 99.01 (a)
DHRS3 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DHRS3 35
  • 92.83 (n)
  • 98.01 (a)
DHRS3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dhrs3 35
  • 88.19 (n)
  • 95.03 (a)
Dhrs3 16
Dhrs3 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DHRS3 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DHRS3 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dhrs3 35
  • 88.74 (n)
  • 95.36 (a)
chicken
(Gallus gallus)
Aves DHRS3 35
  • 80.57 (n)
  • 90.07 (a)
DHRS3 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHRS3 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13360 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dhrs3 35
  • 74.17 (n)
  • 84.11 (a)
Str.2573 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5264 35
zebrafish
(Danio rerio)
Actinopterygii dhrs3a 36
  • 77 (a)
OneToMany
dhrs3b 35
  • 74.61 (n)
  • 78.48 (a)
dhrs3b 36
  • 79 (a)
OneToMany
wufc04h12 35
fruit fly
(Drosophila melanogaster)
Insecta CG13833 36
  • 24 (a)
ManyToMany
CG14946 36
  • 28 (a)
ManyToMany
CG15629 36
  • 31 (a)
ManyToMany
CG17121 36
  • 22 (a)
ManyToMany
CG2254 36
  • 27 (a)
ManyToMany
CG9265 36
  • 24 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dhs-29 36
  • 18 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 21 (a)
ManyToMany
TDA5 36
  • 20 (a)
ManyToMany
Species with no ortholog for DHRS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHRS3 Gene

ENSEMBL:
Gene Tree for DHRS3 (if available)
TreeFam:
Gene Tree for DHRS3 (if available)

Paralogs for DHRS3 Gene

Paralogs for DHRS3 Gene

Selected SIMAP similar genes for DHRS3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DHRS3: view

Variants for DHRS3 Gene

Sequence variations from dbSNP and Humsavar for DHRS3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4580 -- 12,568,159(-) TGGGT(A/G)TAACT utr-variant-3-prime
rs15636 -- 12,606,271(+) TTCAT(C/T)TTGTT intron-variant
rs1128251 - 12,617,344(-) GATGG(C/T)GTGGA missense, reference, upstream-variant-2KB
rs1128256 -- 12,578,831(-) TCAGC(C/T)TTCGC reference, synonymous-codon, intron-variant
rs1128298 -- 12,568,064(-) TGCTT(C/T)TCAAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DHRS3 Gene

Variant ID Type Subtype PubMed ID
nsv517848 CNV Gain 19592680
essv17144 CNV CNV 17122850
dgv20e1 CNV Complex 17122850
nsv521737 CNV Loss 19592680
nsv871052 CNV Loss 21882294
nsv466172 CNV Loss 19166990
nsv466283 CNV Gain 19166990
dgv145n71 CNV Gain 21882294
nsv870867 CNV Gain 21882294
dgv21e1 CNV Complex 17122850
nsv428410 CNV Gain+Loss 18775914

Relevant External Links for DHRS3 Gene

HapMap Linkage Disequilibrium report
DHRS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHRS3 Gene

Disorders for DHRS3 Gene

Relevant External Links for DHRS3

Genetic Association Database (GAD)
DHRS3
Human Genome Epidemiology (HuGE) Navigator
DHRS3
genes like me logo Genes that share disorders with DHRS3: view

No data available for UniProtKB/Swiss-Prot for DHRS3 Gene

Publications for DHRS3 Gene

  1. Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal. (PMID: 9705317) Haeseleer F. … Palczewski K. (J. Biol. Chem. 1998) 2 3 4 23 25
  2. retSDR1, a short-chain retinol dehydrogenase/reductase, is retinoic acid-inducible and frequently deleted in human neuroblastoma cell lines. (PMID: 11861404) Cerignoli F. … Giannini G. (Cancer Res. 2002) 3 4 25
  3. Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina. (PMID: 12226107) Haeseleer F. … Palczewski K. (J. Biol. Chem. 2002) 2 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4

Products for DHRS3 Gene

Sources for DHRS3 Gene

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