Aliases for DHRS2 Gene
External Ids for DHRS2 Gene
Previous GeneCards Identifiers for DHRS2 Gene
GeneCards Summary for DHRS2 Gene
DHRS2 (Dehydrogenase/Reductase 2) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and carbonyl reductase (NADPH) activity. An important paralog of this gene is DHRS4.
UniProtKB/Swiss-Prot for DHRS2 Gene
Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.