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Aliases for DHRS2 Gene

Aliases for DHRS2 Gene

  • Dehydrogenase/Reductase (SDR Family) Member 2 2 3
  • Short Chain Dehydrogenase/Reductase Family 25C Member 1 3 4
  • Dicarbonyl Reductase HEP27 3 4
  • Protein D 3 4
  • SDR25C1 3 4
  • HEP27 3 6
  • Dehydrogenase/Reductase SDR Family Member 2, Mitochondrial 3
  • Short Chain Dehydrogenase/Reductase Family 25C, Member 1 3
  • Short-Chain Alcohol Dehydrogenase Family Member 3
  • Short Chain Dehydrogenase/Reductase Family 25C 2
  • Dehydrogenase/Reductase Member 2 3
  • EC 1.1.1.184 63
  • EC 1.1.1.- 4
  • Member 1 2

External Ids for DHRS2 Gene

Previous GeneCards Identifiers for DHRS2 Gene

  • GC14P021478
  • GC14P017892
  • GC14P022089
  • GC14P022095
  • GC14P023175
  • GC14P024099
  • GC14P004222

Summaries for DHRS2 Gene

GeneCards Summary for DHRS2 Gene

DHRS2 (Dehydrogenase/Reductase (SDR Family) Member 2) is a Protein Coding gene. GO annotations related to this gene include carbonyl reductase (NADPH) activity. An important paralog of this gene is DECR2.

UniProtKB/Swiss-Prot for DHRS2 Gene

  • Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.

Gene Wiki entry for DHRS2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS2 Gene

Genomics for DHRS2 Gene

Regulatory Elements for DHRS2 Gene

Genomic Location for DHRS2 Gene

Start:
23,630,115 bp from pter
End:
23,645,639 bp from pter
Size:
15,525 bases
Orientation:
Plus strand

Genomic View for DHRS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHRS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS2 Gene

Proteins for DHRS2 Gene

  • Protein details for DHRS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13268-DHRS2_HUMAN
    Recommended name:
    Dehydrogenase/reductase SDR family member 2, mitochondrial
    Protein Accession:
    Q13268
    Secondary Accessions:
    • D3DS54
    • Q53GS4
    • Q7Z789
    • Q9H2R2

    Protein attributes for DHRS2 Gene

    Size:
    280 amino acids
    Molecular mass:
    29927 Da
    Quaternary structure:
    • Directly interacts with MDM2; this interaction occurs in the nucleus and does not target DHRS2 to degradation.

    Alternative splice isoforms for DHRS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHRS2 Gene

Proteomics data for DHRS2 Gene at MOPED

Selected DME Specific Peptides for DHRS2 Gene

Post-translational modifications for DHRS2 Gene

  • Ubiquitination at Lys224 and Lys234
  • Modification sites at PhosphoSitePlus

Other Protein References for DHRS2 Gene

Domains for DHRS2 Gene

Gene Families for DHRS2 Gene

HGNC:
  • SDRC1 :Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 1

Suggested Antigen Peptide Sequences for DHRS2 Gene

Graphical View of Domain Structure for InterPro Entry

Q13268

UniProtKB/Swiss-Prot:

DHRS2_HUMAN :
  • Q13268
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS2: view

Function for DHRS2 Gene

Molecular function for DHRS2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.3 mM for 1-Phenyl-1,2-propanedione {ECO:0000269 PubMed:16685466}; KM=1.1 mM for 2,3-Heptanedione {ECO:0000269 PubMed:16685466}; KM=0.8 mM for 3,4-Hexanedione {ECO:0000269 PubMed:16685466}; Vmax=0.52 mmol/min/mg enzyme with 1-Phenyl-1,2-propanedione as substrate {ECO:0000269 PubMed:16685466}; Vmax=0.64 mmol/min/mg enzyme with 2,3-Heptanedione as substrate {ECO:0000269 PubMed:16685466}; Vmax=0.35 mmol/min/mg enzyme with 3,4-Hexanedione as substrate {ECO:0000269 PubMed:16685466};
UniProtKB/Swiss-Prot Function: Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.
UniProtKB/Swiss-Prot Induction: Up-regulated by IL4 and CSF2 in monocytes/macrophages. Down-regulated by bacterial lipopolysaccharides (LPS) and TNF in monocytice-derived dendritic cells. Up-regulated by MYB.

Enzyme Numbers (IUBMB) for DHRS2 Gene

Gene Ontology (GO) - Molecular Function for DHRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004090 carbonyl reductase (NADPH) activity IDA 16685466
GO:0005515 protein binding IPI 25416956
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with DHRS2: view

Phenotypes for DHRS2 Gene

genes like me logo Genes that share phenotypes with DHRS2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DHRS2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DHRS2 Gene

Localization for DHRS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHRS2 Gene

Mitochondrion matrix. Nucleus. Note=A minor fraction of the protein is translocated from the mitochondria to the nucleus, after cleavage of the targeting signal.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHRS2 Gene COMPARTMENTS Subcellular localization image for DHRS2 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for DHRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 1847869
GO:0005635 nuclear envelope IDA 11997086
GO:0005737 cytoplasm IDA 11944995
GO:0005739 mitochondrion IDA 19443906
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with DHRS2: view

Pathways for DHRS2 Gene

SuperPathways for DHRS2 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase I Enzymes in human,mouse,rat

Gene Ontology (GO) - Biological Process for DHRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0008207 C21-steroid hormone metabolic process NAS 7556196
GO:0008285 negative regulation of cell proliferation NAS 1847869
GO:0009636 response to toxic substance IDA 16685466
GO:0034599 cellular response to oxidative stress IDA 19443906
genes like me logo Genes that share ontologies with DHRS2: view

No data available for Pathways by source for DHRS2 Gene

Compounds for DHRS2 Gene

(1) HMDB Compounds for DHRS2 Gene

Compound Synonyms Cas Number PubMed IDs
Cortisone
  • Andreson
53-06-5

(10) Novoseek inferred chemical compound relationships for DHRS2 Gene

Compound -log(P) Hits PubMed IDs
17beta-hydroxysteroid 87 5
11-cis-retinol 81.9 1
retinaldehyde 71.9 1
11beta-hydroxysteroid 71.2 2
vitamin a 56.4 4
genes like me logo Genes that share compounds with DHRS2: view

Transcripts for DHRS2 Gene

Unigene Clusters for DHRS2 Gene

Dehydrogenase/reductase (SDR family) member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DHRS2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c · 10d
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - - - -
SP5: - -
SP6: - - -
SP7: -
SP8: - - - - - -

Relevant External Links for DHRS2 Gene

GeneLoc Exon Structure for
DHRS2
ECgene alternative splicing isoforms for
DHRS2

Expression for DHRS2 Gene

mRNA expression in normal human tissues for DHRS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DHRS2 Gene

This gene is overexpressed in Bladder (42.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHRS2 Gene

SOURCE GeneReport for Unigene cluster for DHRS2 Gene Hs.272499

mRNA Expression by UniProt/SwissProt for DHRS2 Gene

Q13268-DHRS2_HUMAN
Tissue specificity: Widely expressed, with highest levels in liver and kidney, followed by heart, spleen, skeletal muscle and placenta. In hemopoietic cells, expressed in dendritic cells, but not in monocytes, macrophages, granulocytes, nor in B and T lymphocytes.
genes like me logo Genes that share expressions with DHRS2: view

In Situ Assay Products

Orthologs for DHRS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DHRS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHRS2 35
  • 97.54 (n)
  • 96.31 (a)
DHRS2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCXR 36
  • 23 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia DHRS2 36
  • 70 (a)
OneToOne
LOC490616 35
  • 82.26 (n)
  • 77.86 (a)
mouse
(Mus musculus)
Mammalia Dhrs2 16
Dhrs2 36
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 63 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 46 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii DHRS2 36
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10672 36
  • 38 (a)
OneToMany
CG10672 37
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea dhs-13 36
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
Species with no ortholog for DHRS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DHRS2 Gene

ENSEMBL:
Gene Tree for DHRS2 (if available)
TreeFam:
Gene Tree for DHRS2 (if available)

Paralogs for DHRS2 Gene

Selected SIMAP similar genes for DHRS2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for DHRS2 Gene

genes like me logo Genes that share paralogs with DHRS2: view

Variants for DHRS2 Gene

Sequence variations from dbSNP and Humsavar for DHRS2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs222605 -- 23,645,545(-) GCTTC(C/T)ACTCC utr-variant-3-prime, downstream-variant-500B, nc-transcript-variant
rs222606 -- 23,645,866(-) TAGCC(A/T)GGAGG downstream-variant-500B
rs222721 -- 23,628,316(+) ggccg(A/G)gcacg upstream-variant-2KB
rs222722 -- 23,629,360(+) ggcat(C/T)ggtca upstream-variant-2KB
rs222723 -- 23,629,422(+) caaca(C/T)ttcag upstream-variant-2KB

Relevant External Links for DHRS2 Gene

HapMap Linkage Disequilibrium report
DHRS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DHRS2 Gene

Disorders for DHRS2 Gene

Relevant External Links for DHRS2

Genetic Association Database (GAD)
DHRS2
Human Genome Epidemiology (HuGE) Navigator
DHRS2
genes like me logo Genes that share disorders with DHRS2: view

No data available for UniProtKB/Swiss-Prot for DHRS2 Gene

Publications for DHRS2 Gene

  1. A nuclear protein, synthesized in growth-arrested human hepatoblastoma cells, is a novel member of the short-chain alcohol dehydrogenase family. (PMID: 7556196) Gabrielli F. … Melli M. (Eur. J. Biochem. 1995) 2 3 4 23
  2. Genomic organization of the human gene HEP27: alternative promoter usage in HepG2 cells and monocyte-derived dendritic cells. (PMID: 11944995) Heinz S. … Rehli M. (Genomics 2002) 2 3 4 23
  3. Hep27, a member of the short-chain dehydrogenase/reductase family, is an NADPH-dependent dicarbonyl reductase expressed in vascular endothelial tissue. (PMID: 16685466) Shafqat N. … Oppermann U. (Cell. Mol. Life Sci. 2006) 2 3 4
  4. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3
  5. A human short-chain dehydrogenase/reductase gene: structure, chromosomal localization, tissue expression and subcellular localization of its product. (PMID: 11997086) Pellegrini S. … Gabrielli F. (Biochim. Biophys. Acta 2002) 3 4

Products for DHRS2 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase I Enzymes in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate DHRS2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for DHRS2
    • Block miRNA regulation of DHRS2 using miScript Target Protectors

    Sources for DHRS2 Gene

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