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DHRS2 Gene

protein-coding   GIFtS: 58
GCID: GC14P024099

Dehydrogenase/Reductase (SDR Family) Member 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dehydrogenase/Reductase (SDR Family) Member 21 2     Dehydrogenase/Reductase Member 22
Dicarbonyl Reductase HEP272 3     Dehydrogenase/Reductase SDR Family Member 2, Mitochondrial2
Protein D2 3     Short Chain Dehydrogenase/Reductase Family 25C, Member 12
HEP272 5     Short-Chain Alcohol Dehydrogenase Family Member2
Member 11     EC 1.1.1.-3
Short Chain Dehydrogenase/Reductase Family 25C1     EC 1.1.1.1848
SDR25C12     

External Ids:    HGNC: 183491   Entrez Gene: 102022   Ensembl: ENSG000001008677   OMIM: 6151945   UniProtKB: Q132683   

Export aliases for DHRS2 gene to outside databases

Previous GC identifers: GC14P021478 GC14P017892 GC14P022089 GC14P022095 GC14P023175 GC14P004222


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DHRS2 Gene:
DHRS2 (dehydrogenase/reductase (SDR family) member 2) is a protein-coding gene. GO annotations related to this gene include carbonyl reductase (NADPH) activity. An important paralog of this gene is HPGD.

UniProtKB/Swiss-Prot: DHRS2_HUMAN, Q13268
Function: Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione
and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids
and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and
increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21

Gene Wiki entry for DHRS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DHRS2 gene promoter:
         TBP   NF-1   NCX/Ncx   HNF-1   FOXO1a   MIF-1   HNF-1A   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDHRS2 promoter sequence
   Search Chromatin IP Primers for DHRS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DHRS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

DHRS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHRS2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P024099:  view genomic region     (about GC identifiers)

Start:
24,099,324 bp from pter      End:
24,114,848 bp from pter
Size:
15,525 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DHRS2_HUMAN, Q13268 (See protein sequence)
Recommended Name: Dehydrogenase/reductase SDR family member 2, mitochondrial precursor  
Size: 280 amino acids; 29927 Da
Subunit: Directly interacts with MDM2; this interaction occurs in the nucleus and does not target DHRS2 to
degradation
Secondary accessions: D3DS54 Q53GS4 Q7Z789 Q9H2R2
Alternative splicing: 2 isoforms:  Q13268-1   Q13268-2   

Explore the universe of human proteins at neXtProt for DHRS2: NX_Q13268

Explore proteomics data for DHRS2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys224, Lys234
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for DHRS2 (Q13268)
     SSRKQQNVD  VCHVGKAEDRE 


    See DHRS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_005785.1  NP_878912.1  

    ENSEMBL proteins: 
     ENSP00000401213   ENSP00000250383   ENSP00000344674   ENSP00000451895   ENSP00000451485  

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    Novus Biologicals DHRS2 Lysate
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    Cloud-Clone Corp. Proteins for DHRS2

     
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    antibodies-online proteins for DHRS2 (5 products) 

     
    antibodies-online peptides for DHRS2

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    antibodies-online antibodies for DHRS2 (42 products) 

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    antibodies-online kits for DHRS2 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SDRC1: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 1

    4 InterPro protein domains:
     IPR020904 Sc_DH/Rdtase_CS
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q13268

    ProtoNet protein and cluster: Q13268

    2 Blocks protein domains:
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature


    UniProtKB/Swiss-Prot: DHRS2_HUMAN, Q13268
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    Find genes that share domains with DHRS2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DHRS2_HUMAN, Q13268
    Function: Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione
    and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids
    and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and
    increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21
    Biophysicochemical properties: Kinetic parameters: KM=0.3 mM for 1-Phenyl-1,2-propanedione; KM=1.1 mM for
    2,3-Heptanedione; KM=0.8 mM for 3,4-Hexanedione; Vmax=0.52 mmol/min/mg enzyme with 1-Phenyl-1,2-propanedione as
    substrate; Vmax=0.64 mmol/min/mg enzyme with 2,3-Heptanedione as substrate; Vmax=0.35 mmol/min/mg enzyme with
    3,4-Hexanedione as substrate;
    Induction: Up-regulated by IL4 and CSF2 in monocytes/macrophages. Down-regulated by bacterial lipopolysaccharides
    (LPS) and TNF in monocytice-derived dendritic cells. Up-regulated by MYB

         Enzyme Numbers (IUBMB): EC 1.1.1.1842 EC 1.1.1.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004090carbonyl reductase (NADPH) activity IDA16685466
    GO:0016491oxidoreductase activity ----
         
    Find genes that share ontologies with DHRS2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DHRS2:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Dhrs2):
     cellular 

    Find genes that share phenotypes with DHRS2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DHRS2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DHRS2_HUMAN, Q13268: Mitochondrion matrix. Nucleus. Note=A minor fraction of the protein is translocated from the
    mitochondria to the nucleus, after cleavage of the targeting signal
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    cytosol1
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA1847869
    GO:0005635nuclear envelope IDA11997086
    GO:0005737cytoplasm IDA11944995
    GO:0005739mitochondrion IDA19443906
    GO:0005759mitochondrial matrix IEA--

    Find genes that share ontologies with DHRS2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including DHRS2: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DHRS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for DHRS2 (Q132683 ENSP000003446744) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GAPDHP044063, ENSP000002292394I2D: score=1 STRING: ENSP00000229239
    CD4P017303, ENSP000000116534I2D: score=1 STRING: ENSP00000011653
    ACTBP607093I2D: score=1 
    ARRB1P494073I2D: score=1 
    EEF1B2P245343I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----
    GO:0008207C21-steroid hormone metabolic process NAS7556196
    GO:0008285negative regulation of cell proliferation NAS1847869
    GO:0009636response to toxic substance IDA16685466
    GO:0034599cellular response to oxidative stress IDA19443906

    Find genes that share ontologies with DHRS2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DHRS2

    1 HMDB Compound for DHRS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CortisoneAndreson (see all 45)53-06-5--

    10 Novoseek inferred chemical compound relationships for DHRS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    17beta-hydroxysteroid 87 5 9070888 (1), 8547181 (1), 11719564 (1), 1639787 (1) (see all 5)
    11-cis-retinol 81.9 1 11140907 (1)
    retinaldehyde 71.9 1 15457346 (1)
    11beta-hydroxysteroid 71.2 2 9070888 (1), 1639208 (1)
    vitamin a 56.4 4 15457346 (1), 10871622 (1), 12372410 (1), 12390888 (1)
    sterol 44.1 2 8547181 (1), 8547180 (1)
    nadph 41.6 1 1714456 (1)
    retinoic acid 40.5 1 15457346 (1)
    steroid 37.5 2 11792704 (1), 8812499 (1)
    lipid 0 1 8547181 (1)



    Find genes that share compounds with DHRS2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DHRS2 gene (2 alternative transcripts): 
    NM_005794.3  NM_182908.4  

    Unigene Cluster for DHRS2:

    Dehydrogenase/reductase (SDR family) member 2
    Hs.272499  [show with all ESTs]
    Unigene Representative Sequence: AK309945
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000553896 ENST00000432832 ENST00000250383(uc001wku.4) ENST00000556701(uc010aku.1 uc010akv.3)
    ENST00000344777(uc001wkt.4) ENST00000556729 ENST00000557535 ENST00000553600
    ENST00000556550
    miRNA
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    Additional mRNA sequence: 

    AK092834.1 AK222857.1 AK309945.1 AK309975.1 BC002786.2 BC007339.2 U31875.1 

    8 DOTS entries:

    DT.205024  DT.97774901  DT.100039094  DT.92427168  DT.100787375  DT.91750272  DT.95287932  DT.100787371 

    Selected AceView cDNA sequences (see all 260):

    BE041674 BQ645350 BU789999 CR624957 CA443900 BU632879 BQ000312 NM_005794 
    BQ651162 CR610479 BQ644553 CB161495 BC007339 BC002786 BX408133 BQ651605 
    BQ651791 CA443846 BG475474 CA454381 BU737970 CA415952 BQ649344 BP371189 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DHRS2 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c · 10d
    SP1:                                            -     -                                         -                                 
    SP2:                                            -     -                                                                           
    SP3:                                            -     -                                   -     -                                 
    SP4:                                            -     -                 -     -                 -                                 
    SP5:                                                  -                                         -                                 


    ECgene alternative splicing isoforms for DHRS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DHRS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGGTTCTT
    DHRS2 Expression
    About this image


    DHRS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Adipose (Muscoskeletal System)
             Mesenchymal Stem Cells Subcutaneous White Adipose
     
     Mesenchymal Stem Cells
             Mesenchymal Stem Cells Subcutaneous White Adipose
     
     Ovary (Reproductive System)
     
     Liver (Hepatobiliary System)
    DHRS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DHRS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.272499

    UniProtKB/Swiss-Prot: DHRS2_HUMAN, Q13268
    Tissue specificity: Widely expressed, with highest levels in liver and kidney, followed by heart, spleen, skeletal
    muscle and placenta. In hemopoietic cells, expressed in dendritic cells, but not in monocytes, macrophages,
    granulocytes, nor in B and T lymphocytes

        Pathway & Disease-focused RT2 Profiler PCR Array including DHRS2: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat DHRS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHRS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DHRS2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dhrs25 dehydrogenase/reductase member 2   --   14 (28.12 cM) 55222007 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    47(a)
    1 → many
    GL343877.1(71502-81133)
    zebrafish
    (Danio rerio)
    Actinopterygii DHRS26
    dehydrogenase/reductase (SDR family) member 2
    46(a)
    1 → many
    7(25206555-25214121) ENSDARG00000021135
    fruit fly
    (Drosophila melanogaster)
    Insecta CG106723 oxidoreductase, acting on CH-OH group
    of donors
    51(a)   64C9   --
    worm
    (Caenorhabditis elegans)
    Secernentea dhs-136
    Protein DHS-13 (dhs-13) mRNA, complete cds
    39(a)
    1 → many
    V(1765319-1771727) WBGene00000976


    ENSEMBL Gene Tree for DHRS2 (if available)
    TreeFam Gene Tree for DHRS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DHRS2 gene
    HPGD2  DCXR2  DECR22  CBR42  PECR2  HSD17B142  HSD17B102  DHRS42  
    BDH22  DHRS4L22  HSD17B82  DECR12  
    7 SIMAP similar genes for DHRS2 using alignment to 4 protein entries:     DHRS2_HUMAN (see all proteins):
    DHRSX    DHRS4    DHRS4L2    DHRS4L1    HPGD    BDH2
    CBR4

    Find genes that share paralogs with DHRS2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for DHRS2
    PGOHUM00000261843


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DHRS2 (see all 446)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358464
    A colorectal cancer sample4--see VAR_0358462 A V mis40--------
    rs1884926481,2
    --24103656(+) TGATCA/GCTGCC 2 -- us2k10--------
    rs2019996281,2
    C--24103714(+) TAGAA-/TTGTTT 2 -- us2k10--------
    rs1482344841,2
    --24103743(+) GTGGAC/GTCAAA 2 -- us2k10--------
    rs1413570951,2
    C--24103747(+) ACTCAA/CATAAT 2 -- us2k10--------
    rs1503669071,2
    C--24103755(+) AATATA/GTATTC 2 -- us2k10--------
    rs1812690141,2
    --24103864(+) ATTCCA/TTTATA 2 -- us2k10--------
    rs1379289841,2
    --24103902(+) TCCACC/TGTTAA 2 -- us2k10--------
    rs1433963551,2
    C--24103963(+) CATGTC/TGAATT 2 -- us2k10--------
    rs1138119851,2
    C--24104039(+) CCTTGC/GTGCTC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DHRS2 (24099324 - 24114848 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DHRS2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DHRS2
    DNA2.0 Custom Variant and Variant Library Synthesis for DHRS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615194    OMIM disorders: --


    Find genes that share disorders with DHRS2           About GenesLikeMe

    Genetic Association Database (GAD): DHRS2
    Human Genome Epidemiology (HuGE) Navigator: DHRS2 (1 document)

    Export disorders for DHRS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DHRS2 gene, integrated from 10 sources (see all 77):
    (articles sorted by number of sources associating them with DHRS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A nuclear protein, synthesized in growth-arrested human hepatoblastoma cells, is a novel member of the short-chain alcohol dehydrogenase family. (PubMed id 7556196)1, 2, 3, 9 Gabrielli F.... Melli M. (Eur. J. Biochem. 1995)
    2. Genomic organization of the human gene HEP27: alternative promoter usage in HepG2 cells and monocyte-derived dendritic cells. (PubMed id 11944995)1, 2, 3, 9 Heinz S....Rehli M. (Genomics 2002)
    3. Hep27, a member of the short-chain dehydrogenase/reductase family, is an NADPH-dependent dicarbonyl reductase expressed in vascular endothelial tissue. (PubMed id 16685466)1, 2, 3 Shafqat N.... Oppermann U. (Cell. Mol. Life Sci. 2006)
    4. Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53. (PubMed id 20547751)1, 2 Deisenroth C.... Zhang Y. (Mol. Cell. Biol. 2010)
    5. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (Chem. Biol. Interact. 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. A human short-chain dehydrogenase/reductase gene: structure, chromosomal localization, tissue expression and subcellular localization of its product. (PubMed id 11997086)1, 2 Pellegrini S.... Gabrielli F. (Biochim. Biophys. Acta 2002)
    8. Identification of a novel nuclear protein synthesized in growth- arrested human hepatoblastoma HepG2 cells. (PubMed id 1847869)1, 2 Donadel G.... Gabrielli F. (Eur. J. Biochem. 1991)
    9. Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes. (PubMed id 23036705)1 Gabrielli F. and Tofanelli S. (Gene 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10202 HGNC: 18349 AceView: DHRS2 Ensembl:ENSG00000100867 euGenes: HUgn10202
    ECgene: DHRS2 H-InvDB: DHRS2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DHRS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DHRS2 gene:
    Search GeneIP for patents involving DHRS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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