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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DHRS2 Gene

protein-coding   GIFtS: 53
GCID: GC14P024099

dehydrogenase/reductase (SDR family) member 2
 Explore 12 diseases affiliated with
DHRS2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DHRS2    

Aliases
for DHRS2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dehydrogenase/Reductase (SDR Family) Member 21 2     Dehydrogenase/Reductase SDR Family Member 22
HEP271 2     Short Chain Dehydrogenase/Reductase Family 25C, Member 12
SDR25C11 2     Short-Chain Alcohol Dehydrogenase Family Member2
Dicarbonyl Reductase HEP272 3     EC 1.1.1.-3
Protein D2 3     EC 1.1.1.1848
Dehydrogenase/Reductase Member 22     

External Ids:    HGNC: 183491   Entrez Gene: 102022   Ensembl: ENSG000001008677   UniProtKB: Q132683   

Export aliases for DHRS2 gene to outside databases

Previous GC identifers: GC14P021478 GC14P017892 GC14P022089 GC14P022095 GC14P023175 GC14P004222


Summaries
for DHRS2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: DHRS2_HUMAN, Q13268
Function: Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and
1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and
sugars as substrates. May inhibit cell replication

Gene Wiki entry for DHRS2


Genomic Views
for DHRS2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DHRS2 gene promoter:
         TBP   NF-1   NCX/Ncx   HNF-1   FOXO1a   MIF-1   HNF-1A   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DHRS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for DHRS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHRS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

DHRS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHRS2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P024099:  view genomic region     (about GC identifiers)

Start:
 24,099,324 bp from pter      End:
 24,114,848 bp from pter
Size:
 15,525 bases      Orientation:
 plus strand

Proteins
for DHRS2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DHRS2_HUMAN, Q13268 (See protein sequence)
Recommended Name: Dehydrogenase/reductase SDR family member 2  
Size: 258 amino acids; 27439 Da
Subcellular location: Nucleus
Sequence caution: Sequence=AAA82048.1; Type=Erroneous initiation; Sequence=AAG33703.1; Type=Erroneous initiation;
Sequence=AAH07339.2; Type=Erroneous initiation; Sequence=BAD96577.1; Type=Erroneous initiation;
Secondary accessions: Q53GS4 Q7Z789 Q9H2R2
Alternative splicing: 2 isoforms:  Q13268-1   Q13268-2   

Explore the universe of human proteins at neXtProt for DHRS2: NX_Q13268

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13268

    • 2 DME Specific Peptides for DHRS2 (Q13268)
     SSRKQQNVD  VCHVGKAEDRE 

    DHRS2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_005785.1  NP_878912.1  

    ENSEMBL proteins: 
     ENSP00000401213   ENSP00000250383   ENSP00000344674   ENSP00000451895   ENSP00000451485  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: DHRS2
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    Novus Biologicals DHRS2 Proteins
    Novus Biologicals DHRS2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DHRS2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA1847869
    GO:0005635nuclear envelope IDA11997086
    GO:0005737cytoplasm IDA11944995
    GO:0005739mitochondrion IDA19443906


    DHRS2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DHRS2

    Protein Domains /
    Families
    for DHRS2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DHRS2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR020904 Sc_DH/Rdtase_CS
     IPR016040 NAD(P)-bd_dom
     IPR027052 DHRS2/4
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR

    Graphical View of Domain Structure for InterPro Entry Q13268

    ProtoNet protein and cluster: Q13268

    2 Blocks protein families:
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature


    UniProtKB/Swiss-Prot: DHRS2_HUMAN, Q13268
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    Function
    for DHRS2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DHRS2_HUMAN, Q13268
    Function: Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and
    1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and
    sugars as substrates. May inhibit cell replication
    Biophysicochemical properties: Kinetic parameters: KM=0.3 mM for 1-Phenyl-1,2-propanedione; KM=1.1 mM for
    2,3-Heptanedione; KM=0.8 mM for 3,4-Hexanedione; Vmax=0.52 mmol/min/mg enzyme with 1-Phenyl-1,2-propanedione as
    substrate; Vmax=0.64 mmol/min/mg enzyme with 2,3-Heptanedione as substrate; Vmax=0.35 mmol/min/mg enzyme with
    3,4-Hexanedione as substrate;

    Enzyme Numbers (IUBMB): EC 1.1.1.1842 EC 1.1.1.-1

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0004090carbonyl reductase (NADPH) activity IDA16685466
    GO:0016491oxidoreductase activity ----


    DHRS2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for DHRS2:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 


    Pathways & Interactions
    for DHRS2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DHRS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/15 Interacting proteins for DHRS2 (Q132683 ENSP000003446744) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GAPDHP044063, ENSP000002292394I2D: score=1 STRING: ENSP00000229239
    CD4P017303, ENSP000000116534I2D: score=1 STRING: ENSP00000011653
    ACTBP607093I2D: score=1 
    ARRB1P494073I2D: score=1 
    EEF1B2P245343I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008207C21-steroid hormone metabolic process NAS7556196
    GO:0008285negative regulation of cell proliferation NAS1847869
    GO:0009636response to toxin IDA16685466
    GO:0034599cellular response to oxidative stress IDA19443906
    GO:0043011myeloid dendritic cell differentiation IEP11944995


    DHRS2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DHRS2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DHRS2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DHRS2

    1 HMDB Compound for DHRS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CortisoneAndreson (see all 45)53-06-5--
    10 Novoseek chemical compound relationships for DHRS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    17beta-hydroxysteroid 87 5 9070888 (1), 8547181 (1), 11719564 (1), 1639787 (1) (see all 5)
    11-cis-retinol 81.9 1 11140907 (1)
    retinaldehyde 71.9 1 15457346 (1)
    11beta-hydroxysteroid 71.2 2 9070888 (1), 1639208 (1)
    vitamin a 56.4 4 15457346 (1), 10871622 (1), 12372410 (1), 12390888 (1)
    sterol 44.1 2 8547181 (1), 8547180 (1)
    nadph 41.6 1 1714456 (1)
    retinoic acid 40.5 1 15457346 (1)
    steroid 37.5 2 11792704 (1), 8812499 (1)
    lipid 0 1 8547181 (1)

    Search CenterWatch for drugs/clinical trials and news about DHRS2 

    Transcripts
    for DHRS2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DHRS2 gene (2 alternative transcripts): 
    NM_005794.3  NM_182908.4  

    Unigene Cluster for DHRS2:

    Dehydrogenase/reductase (SDR family) member 2
    Hs.272499  [show with all ESTs]
    Unigene Representative Sequence: AK309945
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000553896 ENST00000432832 ENST00000250383(uc001wku.4) ENST00000556701(uc010aku.1 uc010akv.3)
    ENST00000344777(uc001wkt.4) ENST00000556729 ENST00000557535 ENST00000553600
    ENST00000556550

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: DHRS2 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DHRS2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHRS2

    Additional cDNA sequence: 

    AK092834.1 AK222857.1 AK309945.1 AK309975.1 BC002786.2 BC007339.2 U31875.1 

    8 DOTS entries:

    DT.205024  DT.97774901  DT.100039094  DT.92427168  DT.100787375  DT.91750272  DT.95287932  DT.100787371 

    24/260 AceView cDNA sequences (see all 260):

    BQ434827 CR624957 CR620554 BQ651100 CR621782 BE041674 BE275597 BC002786 
    BQ644542 BM928449 CA443846 CA443900 BQ654152 BQ651605 BQ427992 BQ270160 
    BU948196 CR611371 CA424167 BQ651162 NM_005794 BX408133 BQ645236 BQ646730 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for DHRS2 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c · 10d
    SP1:                                            -     -                                         -                                 
    SP2:                                            -     -                                                                           
    SP3:                                            -     -                                   -     -                                 
    SP4:                                            -     -                 -     -                 -                                 
    SP5:                                                  -                                         -                                 


    ECgene alternative splicing isoforms for DHRS2

    Expression
    for DHRS2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DHRS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGGGTTCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See DHRS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DHRS2

    SOURCE GeneReport for Unigene cluster: Hs.272499
        SABiosciences Expression via Pathway-Focused PCR Array including DHRS2: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for DHRS2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DHRS2 gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DHRS26
    		 --
    		 42(a)
    		 1 → many
    		 Un(27498468-27500621)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 46(a)
    		 1 → many
    		 GL343877.1(71502-81133)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:659876
    zgc:1018586
    		 zgc:101858
    		 42(a)
    24(a)
    		 1 ↔ many
    possible ortholog
    		 7(25206555-25214121)
    5(68434002-68438636)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG106723 oxidoreductase, acting on CH-OH group of
    donors    		 51(a)   64C9   --
    worm
    (Caenorhabditis elegans)    		 Secernentea dhs-136
    F54F3.46
    (see all 22)    		 --
    		 37(a)
    34(a)
    (see all 22)    		 1 ↔ many
    possible ortholog
    (see all 22)    		 V(1765319-1771727)
    V(12922590-12924139)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons IBR16
    		 dehydrogenase/reductase SDR family member 4
    		 39(a)
    		 1 → many
    		 4(2816392-2818365)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 dehydrogenase/reductase SDR family member 2, putat...
    		 40(a)
    		 1 → many
    		 9(2511441-2516277)


    ENSEMBL Gene Tree for DHRS2 (if available)
    TreeFam Gene Tree for DHRS2 (if available) 

    Paralogs
    for DHRS2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DHRS2 gene
    DECR22  DCXR2  PECR2  HSD17B142  BDH22  DHRS42  DHRS4L22  DECR12  
    8 SIMAP similar genes for DHRS2 using alignment to 5 protein entries:     DHRS2_HUMAN (see all proteins):
    DHRSX    DHRS4    DHRS4L2    DHRS4L1    HPGD    PECR
    CBR4    BDH2

    DHRS2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DHRS2
    PGOHUM00000261843


    Genomic Variants
    for DHRS2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/353 NCBI SNPs in DHRS2 are shown (see all 353)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1884926481,2
    		--24103656(+) TGATCA/GCTGCC 2 -- us2k10--------
    rs2019996281,2
    		--24103714(+) TAGAA-/TTGTTT 2 -- us2k10--------
    rs1482344841,2
    		--24103743(+) GTGGAC/GTCAAA 2 -- us2k10--------
    rs1413570951,2
    		--24103747(+) ACTCAA/CATAAT 2 -- us2k10--------
    rs1503669071,2
    		--24103755(+) AATATA/GTATTC 2 -- us2k10--------
    rs1812690141,2
    		--24103864(+) ATTCCA/TTTATA 2 -- us2k10--------
    rs1379289841,2
    		--24103902(+) TCCACC/TGTTAA 2 -- us2k10--------
    rs1433963551,2
    		--24103963(+) CATGTC/TGAATT 2 -- us2k10--------
    rs1138119851,2
    		C,--24104039(+) CCTTGC/GTGCTC 2 -- us2k10--------
    rs1403895191,2
    		--24104308(+) GCTCTC/GTCTCC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DHRS2 (24099324 - 24114848 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DHRS2: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for DHRS2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DHRS2 for disorders           About GeneDecksing

    12 diseases for DHRS2:    About MalaCards
    otitis media    haemophilus influenzae    alcoholism    influenza
    hepatoblastoma    alzheimer's disease    psoriasis    breast cancer
    retinitis    tuberculosis    hepatitis    mycobacterium tuberculosis

    Human Genome Epidemiology (HuGE) Navigator: DHRS2 (1 document)

    Export disorders for DHRS2 gene to outside databases

    Publications
    for DHRS2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DHRS2 gene, integrated from 9 sources (see all 74):
    (articles sorted by number of sources associating them with DHRS2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A nuclear protein, synthesized in growth-arrested human hepatoblastoma cells, is a novel member of the short-chain alcohol dehydrogenase family. (PubMed id 7556196)1, 2, 3, 9 Gabrielli F.... Melli M. (1995)
    2. Hep27, a member of the short-chain dehydrogenase/reductase family, is an NADPH-dependent dicarbonyl reductase expressed in vascular endothelial tissue. (PubMed id 16685466)1, 2, 3 Shafqat N.... Oppermann U. (2006)
    3. Genomic organization of the human gene HEP27: alternative promoter usage in HepG2 cells and monocyte-derived dendritic cells. (PubMed id 11944995)1, 3, 9 Heinz S....Rehli M. (2002)
    4. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A human short-chain dehydrogenase/reductase gene: structure, chromosomal localization, tissue expression and subcellular localization of its product. (PubMed id 11997086)1, 2 Pellegrini S.... Gabrielli F. (2002)
    7. Identification of a novel nuclear protein synthesized in growth- arrested human hepatoblastoma HepG2 cells. (PubMed id 1847869)1, 2 Donadel G.... Gabrielli F. (1991)
    8. Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes. (PubMed id 23036705)1 Gabrielli F. and Tofanelli S. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    External Searches for DHRS2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing DHRS2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10202 HGNC: 18349 AceView: DHRS2 Ensembl:ENSG00000100867 euGenes: HUgn10202
    ECgene: DHRS2 H-InvDB: DHRS2

    Other Databases showing DHRS2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DHRS2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DHRS2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DHRS2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DHRS2 gene:
    Search GeneIP for patents involving DHRS2

    GeneCards and IP:
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