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Aliases for DHRS12 Gene

Aliases for DHRS12 Gene

  • Dehydrogenase/Reductase 12 2 3 5
  • Short-Chain Dehydrogenase/Reductase Family 40C Member 1 3 4
  • Dehydrogenase/Reductase (SDR Family) Member 12 2 3
  • SDR40C1 3 4
  • Short Chain Dehydrogenase/Reductase Family 40C, Member 1 2
  • Dehydrogenase/Reductase SDR Family Member 12 3
  • EC 1.1.-.- 4

External Ids for DHRS12 Gene

Previous GeneCards Identifiers for DHRS12 Gene

  • GC13M051241
  • GC13M052342
  • GC13M033131
  • GC13M051756

Summaries for DHRS12 Gene

Entrez Gene Summary for DHRS12 Gene

  • This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for DHRS12 Gene

DHRS12 (Dehydrogenase/Reductase 12) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and coenzyme binding. An important paralog of this gene is RDH12.

UniProtKB/Swiss-Prot for DHRS12 Gene

  • Putative oxidoreductase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS12 Gene

Genomics for DHRS12 Gene

Regulatory Elements for DHRS12 Gene

Enhancers for DHRS12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around DHRS12 on UCSC Golden Path with GeneCards custom track

Genomic Location for DHRS12 Gene

Chromosome:
13
Start:
51,767,993 bp from pter
End:
51,804,199 bp from pter
Size:
36,207 bases
Orientation:
Minus strand

Genomic View for DHRS12 Gene

Genes around DHRS12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHRS12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHRS12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS12 Gene

Proteins for DHRS12 Gene

  • Protein details for DHRS12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0PJE2-DHR12_HUMAN
    Recommended name:
    Dehydrogenase/reductase SDR family member 12
    Protein Accession:
    A0PJE2
    Secondary Accessions:
    • Q96GB2
    • Q9H8H1

    Protein attributes for DHRS12 Gene

    Size:
    317 amino acids
    Molecular mass:
    35146 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DHRS12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHRS12 Gene

Post-translational modifications for DHRS12 Gene

No Post-translational modifications

Other Protein References for DHRS12 Gene

No data available for DME Specific Peptides for DHRS12 Gene

Domains & Families for DHRS12 Gene

Gene Families for DHRS12 Gene

Protein Domains for DHRS12 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DHRS12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A0PJE2

UniProtKB/Swiss-Prot:

DHR12_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS12: view

Function for DHRS12 Gene

Molecular function for DHRS12 Gene

UniProtKB/Swiss-Prot Function:
Putative oxidoreductase.

Enzyme Numbers (IUBMB) for DHRS12 Gene

Gene Ontology (GO) - Molecular Function for DHRS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with DHRS12: view
genes like me logo Genes that share phenotypes with DHRS12: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DHRS12 Gene

Localization for DHRS12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHRS12 Gene COMPARTMENTS Subcellular localization image for DHRS12 gene
Compartment Confidence
mitochondrion 3
cytosol 2
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DHRS12 Gene

Pathways & Interactions for DHRS12 Gene

SuperPathways for DHRS12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHRS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DHRS12: view

No data available for Pathways by source and SIGNOR curated interactions for DHRS12 Gene

Drugs & Compounds for DHRS12 Gene

No Compound Related Data Available

Transcripts for DHRS12 Gene

Unigene Clusters for DHRS12 Gene

Dehydrogenase/reductase (SDR family) member 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS12 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
SP1: - - - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - - -
SP5: - -
SP6:
SP7: - -
SP8: - -
SP9: -

Relevant External Links for DHRS12 Gene

GeneLoc Exon Structure for
DHRS12
ECgene alternative splicing isoforms for
DHRS12

Expression for DHRS12 Gene

mRNA expression in normal human tissues for DHRS12 Gene

mRNA differential expression in normal tissues according to GTEx for DHRS12 Gene

This gene is overexpressed in Whole Blood (x5.5).

NURSA nuclear receptor signaling pathways regulating expression of DHRS12 Gene:

DHRS12

SOURCE GeneReport for Unigene cluster for DHRS12 Gene:

Hs.266728
genes like me logo Genes that share expression patterns with DHRS12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for DHRS12 Gene

Orthologs for DHRS12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHRS12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DHRS12 34
  • 86.44 (n)
  • 85.49 (a)
DHRS12 35
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DHRS12 34
  • 98.74 (n)
  • 96.53 (a)
DHRS12 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 25 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia DHRS12 35
  • 12 (a)
OneToOne
chicken
(Gallus gallus)
Aves DHRS12 34
  • 70.87 (n)
  • 71.61 (a)
DHRS12 35
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHRS12 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhrs12 34
  • 69.09 (n)
  • 68.04 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15580 34
zebrafish
(Danio rerio)
Actinopterygii dhrs12 34
  • 64.88 (n)
  • 65.93 (a)
wufj52f06 34
dhrs12 35
  • 66 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dhs-17 35
  • 20 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENV9 35
  • 21 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G09750 34
  • 51.66 (n)
  • 46.74 (a)
rice
(Oryza sativa)
Liliopsida Os06g0590301 34
  • 49.32 (n)
  • 39.02 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 54 (a)
OneToOne
Species where no ortholog for DHRS12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHRS12 Gene

ENSEMBL:
Gene Tree for DHRS12 (if available)
TreeFam:
Gene Tree for DHRS12 (if available)

Paralogs for DHRS12 Gene

Paralogs for DHRS12 Gene

(3) SIMAP similar genes for DHRS12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DHRS12: view

Variants for DHRS12 Gene

Sequence variations from dbSNP and Humsavar for DHRS12 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs2734 -- 51,793,071(-) TGGCT(A/G)TGTCC intron-variant
rs2735 -- 51,793,057(+) TCATG(C/G)TTATC intron-variant
rs10676 -- 51,769,255(-) GGTTC(A/G)GGGAC reference, missense, utr-variant-3-prime
rs475551 -- 51,785,633(+) GAGGA(C/G/T)ACAAG intron-variant
rs481133 -- 51,786,278(-) TCACC(A/G)CAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHRS12 Gene

Variant ID Type Subtype PubMed ID
dgv1652n100 CNV loss 25217958
dgv3146n54 CNV loss 21841781
esv1177213 CNV deletion 17803354
esv2096973 CNV deletion 18987734
esv26805 CNV gain+loss 19812545
esv2747420 CNV deletion 23290073
esv2747421 CNV deletion 23290073
esv2747422 CNV deletion 23290073
esv3892343 CNV gain 25118596
nsv1069755 CNV deletion 25765185
nsv1078204 CNV insertion 25765185
nsv1124896 CNV deletion 24896259
nsv1148485 CNV deletion 26484159
nsv1151135 CNV insertion 26484159
nsv561646 CNV gain 21841781
nsv561647 CNV gain 21841781
nsv561648 CNV loss 21841781
nsv64332 CNV deletion 16902084
nsv821576 CNV deletion 20802225
nsv832612 CNV gain 17160897

Variation tolerance for DHRS12 Gene

Residual Variation Intolerance Score: 85.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.84; 47.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHRS12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DHRS12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHRS12 Gene

Disorders for DHRS12 Gene

Relevant External Links for DHRS12

Genetic Association Database (GAD)
DHRS12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHRS12

No disorders were found for DHRS12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHRS12 Gene

Publications for DHRS12 Gene

  1. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3 4 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 65
  4. Isolation and characterization of proteins associated with histone H3 tails in vivo. (PMID: 17403666) Heo K. … An W. (J. Biol. Chem. 2007) 3 65
  5. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 4 65

Products for DHRS12 Gene

Sources for DHRS12 Gene

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