DHRS12 Gene
protein-coding GIFtS: 44
GCID: GC13M052342
|
|
dehydrogenase/reductase (SDR family) member 12
| |
Aliases
for DHRS12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dehydrogenase/Reductase (SDR Family) Member 121 2 | | SDR40C11 2 | | FLJ136391 | | Dehydrogenase/Reductase SDR Family Member 122 | | Short Chain Dehydrogenase/Reductase Family 40C, Member 12 | | EC 1.1.-.-3 |
Export aliases for DHRS12 gene to outside databasesPrevious GC identifers: GC13M051241 GC13M033131 |
Summaries
for DHRS12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DHRS12:
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members.Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins,retinoids, lipids and xenobiotics. Alternative splicing results in multiple transcript variants and protein isoforms.(provided by RefSeq, Jul 2012)
UniProtKB/Swiss-Prot: DHR12_HUMAN, A0PJE2Function: Putative oxidoreductase (By similarity)
|
Genomic Views
for DHRS12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for DHRS12
Other transcription factors
Search SABiosciences Chromatin IP Primers for DHRS12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHRS12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q14.3 Ensembl cytogenetic band: 13q14.3 HGNC cytogenetic band: 13q14.3DHRS12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M052342: view genomic region
(about GC identifiers)
Start:
|
52,342,129 bp from pter |
End:
|
52,378,293 bp from pter |
Size:
|
36,165 bases |
Orientation:
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minus strand |
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Proteins
for DHRS12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DHR12_HUMAN, A0PJE2 (See
protein sequence)Recommended Name: Dehydrogenase/reductase SDR family member 12 Size: 317 amino acids; 35146 Da
Secondary accessions: Q96GB2 Q9H8H1Alternative splicing: 3 isoforms: A0PJE2-1 A0PJE2-2 A0PJE2-3 Explore the universe of human proteins at neXtProt for DHRS12: NX_A0PJE2
DHRS12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001026889.1 NP_001257353.1 NP_078981.1
ENSEMBL proteins: ENSP00000411565 ENSP00000218981 ENSP00000280056
Human Recombinant Protein Products for DHRS12:
DHRS12 Antibody Products:
Assay Products for DHRS12: |
Protein
Domains /
Families
for DHRS12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DHRS12 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A0PJE2ProtoNet protein and cluster: A0PJE2 UniProtKB/Swiss-Prot: DHR12_HUMAN, A0PJE2Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family |
Function
for DHRS12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: DHR12_HUMAN, A0PJE2Function: Putative oxidoreductase (By similarity) Enzyme Number (IUBMB): EC 1.1.-.-1
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0016491 | oxidoreductase activity |
IEA | -- |
DHRS12 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for DHRS12:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DHRS12 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DHRS12 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): DHRS12 (NM_024705) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DHRS12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHRS12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHRS12 |
|
Pathways & Interactions
for DHRS12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DHRS12
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for DHRS12 (A0PJE23 ENSP000002800564) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for DHRS12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DHRS12
Search CenterWatch for drugs/clinical trials and news about DHRS12 / DHR12
|
Transcripts
for DHRS12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DHRS12 gene (3 alternative transcripts): NM_001031719.2 NM_001270424.1 NM_024705.2 Unigene Cluster for DHRS12: Dehydrogenase/reductase (SDR family) member 12 Hs.266728 [show with all ESTs]Unigene Representative Sequence: NM_0247059 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000444610(uc001vfq.3) ENST00000218981(uc001vfr.1) ENST00000469957
ENST00000280056(uc001vfs.1) ENST00000472372 ENST00000489680 ENST00000490949
ENST00000461948 ENST00000497151
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DHRS12 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DHRS12 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): DHRS12 (NM_024705) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DHRS12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHRS12 |
Additional cDNA sequence: AK023701.1 BC009825.2 BC026024.1 13 DOTS entries: DT.455352 DT.101980646 DT.205130 DT.86854482 DT.120786320 DT.407697 DT.70102167 DT.95263962 DT.92064438 DT.95343598 DT.100778464 DT.95263963 DT.86854483 24/102 AceView cDNA sequences (see all 102): BM719560 BU078654 NM_024705 AI262961 AI189664 BM715609 AI149118 AV706821 BC026024 AW316534 AA026712 AI688167 Z41435 AI627470 AI138671 AU139727 BC009825 AI676036 CD676290 AK023701 BF438027 AI024367 CB046634 W58728
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for DHRS12 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13 |
|---|
|
| SP1: | | | | | - | | | | - | | | | | | | | - | | | | | | - | | | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | - | | | | | | | | - | | | | | | - | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for DHRS12
|
Expression
for DHRS12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DHRS12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGTGGCTGG
About this image
See DHRS12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DHRS12
SOURCE GeneReport for Unigene cluster: Hs.266728
SABiosciences Custom PCR Arrays for DHRS12
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DHRS12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat DHRS12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DHRS12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHRS12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHRS12 |
Orthologs
for DHRS12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DHRS12 gene from 8/16 species (see all 16) About this table
ENSEMBL Gene Tree for DHRS12 (if available)
TreeFam Gene Tree for DHRS12 (if available) |
Paralogs
for DHRS12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DHRS12 gene
- ENSG000002671492 RDH132 WWOX2 DHRSX2 RDH122 DHRS132 RDH142 RDH112
3 SIMAP similar genes for DHRS12 using alignment to 1 protein entry: DHR12_HUMAN:RDH11 RDH12 RDH13
DHRS12 for paralogs About GeneDecksing
|
Genomic Variants
for DHRS12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DHRS12 (52342129 - 52378293 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for DHRS12
5 CNVs: 23467 5710 4804 43884 71714 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DHRS12 |
|
Disorders
/ Diseases
for DHRS12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for DHRS12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DHRS12 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DHRS12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Isolation and characterization of proteins associated with histone H3 tails in vivo. (PubMed id 17403666)1 Heo K....An W. (2007)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for DHRS12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DHRS12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DHRS12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DHRS12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DHRS12 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DHRS12 gene:
Search GeneIP for patents involving DHRS12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DHRS12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DHRS12 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DHRS12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DHRS12 | | | OriGene Protein Over-expression Lysate for DHRS12 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DHRS12 | | OriGene 3'-UTR Clone for DHRS12 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DHRS12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DHRS12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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 |
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| | | | Search Tocris compounds for DHRS12 |
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 | | | DHRS12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHRS12 |
|  |  |  |  | | | | ThermoFisher Antibodies for DHRS12 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHRS12 |
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