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Aliases for DHRS12 Gene

Aliases for DHRS12 Gene

  • Dehydrogenase/Reductase (SDR Family) Member 12 2 3
  • Short-Chain Dehydrogenase/Reductase Family 40C Member 1 3 4
  • SDR40C1 3 4
  • Short Chain Dehydrogenase/Reductase Family 40C, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 40C 2
  • EC 1.1.-.- 4
  • Member 1 2

External Ids for DHRS12 Gene

Previous GeneCards Identifiers for DHRS12 Gene

  • GC13M051241
  • GC13M052342
  • GC13M033131
  • GC13M051756

Summaries for DHRS12 Gene

Entrez Gene Summary for DHRS12 Gene

  • This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for DHRS12 Gene

DHRS12 (Dehydrogenase/Reductase (SDR Family) Member 12) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and coenzyme binding. An important paralog of this gene is ENSG00000258466.

UniProtKB/Swiss-Prot for DHRS12 Gene

  • Putative oxidoreductase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS12 Gene

Genomics for DHRS12 Gene

Genomic Location for DHRS12 Gene

51,767,993 bp from pter
51,804,199 bp from pter
36,207 bases
Minus strand

Genomic View for DHRS12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHRS12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS12 Gene

No data available for Regulatory Elements for DHRS12 Gene

Proteins for DHRS12 Gene

  • Protein details for DHRS12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dehydrogenase/reductase SDR family member 12
    Protein Accession:
    Secondary Accessions:
    • Q96GB2
    • Q9H8H1

    Protein attributes for DHRS12 Gene

    317 amino acids
    Molecular mass:
    35146 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DHRS12 Gene


neXtProt entry for DHRS12 Gene

Proteomics data for DHRS12 Gene at MOPED

Post-translational modifications for DHRS12 Gene

No Post-translational modifications

Other Protein References for DHRS12 Gene

No data available for DME Specific Peptides for DHRS12 Gene

Domains & Families for DHRS12 Gene

Gene Families for DHRS12 Gene

Protein Domains for DHRS12 Gene

Suggested Antigen Peptide Sequences for DHRS12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS12: view

Function for DHRS12 Gene

Molecular function for DHRS12 Gene

UniProtKB/Swiss-Prot Function:
Putative oxidoreductase.

Enzyme Numbers (IUBMB) for DHRS12 Gene

Gene Ontology (GO) - Molecular Function for DHRS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with DHRS12: view
genes like me logo Genes that share phenotypes with DHRS12: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DHRS12 Gene

Localization for DHRS12 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for DHRS12 Gene

Pathways & Interactions for DHRS12 Gene

SuperPathways for DHRS12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHRS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DHRS12: view

No data available for Pathways by source and SIGNOR curated interactions for DHRS12 Gene

Drugs & Compounds for DHRS12 Gene

No Compound Related Data Available

Transcripts for DHRS12 Gene

Unigene Clusters for DHRS12 Gene

Dehydrogenase/reductase (SDR family) member 12:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DHRS12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS12 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
SP1: - - - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - - -
SP5: - -
SP7: - -
SP8: - -
SP9: -

Relevant External Links for DHRS12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHRS12 Gene

mRNA expression in normal human tissues for DHRS12 Gene

mRNA differential expression in normal tissues according to GTEx for DHRS12 Gene

This gene is overexpressed in Whole Blood (x5.5).

SOURCE GeneReport for Unigene cluster for DHRS12 Gene Hs.266728

genes like me logo Genes that share expression patterns with DHRS12: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DHRS12 Gene

Orthologs for DHRS12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHRS12 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DHRS12 35
  • 86.44 (n)
  • 85.49 (a)
DHRS12 36
  • 85 (a)
(Pan troglodytes)
Mammalia DHRS12 35
  • 98.74 (n)
  • 96.53 (a)
DHRS12 36
  • 97 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 25 (a)
(Ornithorhynchus anatinus)
Mammalia DHRS12 36
  • 12 (a)
(Gallus gallus)
Aves DHRS12 35
  • 70.87 (n)
  • 71.61 (a)
DHRS12 36
  • 69 (a)
(Anolis carolinensis)
Reptilia DHRS12 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dhrs12 35
  • 69.09 (n)
  • 68.04 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15580 35
(Danio rerio)
Actinopterygii dhrs12 35
  • 64.88 (n)
  • 65.93 (a)
wufj52f06 35
dhrs12 36
  • 66 (a)
(Caenorhabditis elegans)
Secernentea dhs-17 36
  • 20 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENV9 36
  • 21 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G09750 35
  • 51.66 (n)
  • 46.74 (a)
(Oryza sativa)
Liliopsida Os06g0590301 35
  • 49.32 (n)
  • 39.02 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
Species with no ortholog for DHRS12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHRS12 Gene

Gene Tree for DHRS12 (if available)
Gene Tree for DHRS12 (if available)

Paralogs for DHRS12 Gene

Paralogs for DHRS12 Gene

(3) SIMAP similar genes for DHRS12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DHRS12: view

Variants for DHRS12 Gene

Structural Variations from Database of Genomic Variants (DGV) for DHRS12 Gene

Variant ID Type Subtype PubMed ID
nsv832612 CNV Gain 17160897
esv26805 CNV Gain+Loss 19812545
esv2096973 CNV Deletion 18987734
nsv821576 CNV Deletion 20802225
nsv64332 CNV Loss 16902084
esv1177213 CNV Deletion 17803354
esv2747420 CNV Deletion 23290073
esv2747421 CNV Deletion 23290073
esv2747422 CNV Deletion 23290073

Variation tolerance for DHRS12 Gene

Residual Variation Intolerance Score: 85.36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.84; 47.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHRS12 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for DHRS12 Gene

Disorders for DHRS12 Gene

Relevant External Links for DHRS12

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DHRS12: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHRS12 Gene

Publications for DHRS12 Gene

  1. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 67
  2. Isolation and characterization of proteins associated with histone H3 tails in vivo. (PMID: 17403666) Heo K. … An W. (J. Biol. Chem. 2007) 67
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 67
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  5. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 67

Products for DHRS12 Gene

Sources for DHRS12 Gene

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