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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DHRS11 Gene

protein-coding   GIFtS: 48
GCID: GC17P034948

dehydrogenase/reductase (SDR family) member 11

 Explore 6 diseases affiliated with
DHRS11 via our new
 Human Malady Compendium 
Biological research products
for DHRS11
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Dehydrogenase/Reductase (SDR Family) Member 111 2     Dehydrogenase/Reductase SDR Family Member 112
SDR24C11 2     Short Chain Dehydrogenase/Reductase Family 24C, Member 12
MGC41721     Short-Chain Dehydrogenase/Reductase2
ARPG8362     EC 1.-.-.-3

External Ids:    HGNC: 286391   Entrez Gene: 791542   Ensembl: ENSG000001082727   UniProtKB: Q6UWP23   

Export aliases for DHRS11 gene to outside databases

Previous GC identifers: GC17P032023 GC17P030885


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DHRS11 gene promoter:
         Max1   XBP-1   POU3F2 (N-Oct-5b)   CUTL1   Nkx2-5   POU3F2   c-Ets-1   PPAR-gamma1   SEF-1 (1)   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for DHRS11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHRS11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

DHRS11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHRS11 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P034948:  view genomic region     (about GC identifiers)

Start:
34,948,226 bp from pter      End:
34,957,235 bp from pter
Size:
9,010 bases      Orientation:
plus strand

1 alternative location:
Chr17+,PATCHES 34,933,990-34,942,997     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DHR11_HUMAN, Q6UWP2 (See protein sequence)
Recommended Name: Dehydrogenase/reductase SDR family member 11 precursor  
Size: 260 amino acids; 28308 Da
Subunit: Homotetramer
Subcellular location: Secreted (Potential)
1 PDB 3D structure from and Proteopedia for DHRS11:
1XG5 (3D)    
Secondary accessions: B2RDZ3 Q9BUC7 Q9H674
Alternative splicing: 2 isoforms:  Q6UWP2-1   Q6UWP2-2   

Explore the universe of human proteins at neXtProt for DHRS11: NX_Q6UWP2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6UWP2

  • DHRS11 Protein expression data from MOPED and PaxDb:    About this image 
    DHRS11 Protein Expression
    REFSEQ proteins: NP_077284.2  
    ENSEMBL proteins: 
     ENSP00000251312   ENSP00000467412   ENSP00000465263   ENSP00000465487   ENSP00000466904  

    Human Recombinant Protein Products for DHRS11: 
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    Novus Biologicals DHRS11 Protein
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DHRS11

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    DHRS11 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DHRS11


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    DHRS11 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR020904 Sc_DH/Rdtase_CS
     IPR016040 NAD(P)-bd_dom
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR

    Graphical View of Domain Structure for InterPro Entry Q6UWP2

    ProtoNet protein and cluster: Q6UWP2

    2 Blocks protein families:
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature


    UniProtKB/Swiss-Prot: DHR11_HUMAN, Q6UWP2
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

         Enzyme Number (IUBMB): EC 1.-.-.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0016491oxidoreductase activity IEA--
         
    DHRS11 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DHRS11:
     Decreased melanin production 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DHRS11 

    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate DHRS11:
    hsa-miR-130a* hsa-miR-23c hsa-miR-551b* hsa-miR-520a-5p hsa-miR-525-5p hsa-miR-23b hsa-miR-23a hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidDHRS11 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHRS11


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DHRS11

    5/142 Interacting proteins for DHRS11 (Q6UWP23) via UniProtKB, MINT, STRING, and/or I2D (see all 142)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DHRS11 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DHRS11

    1 DrugBank Compound for DHRS11    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2'-Monophosphoadenosine 5'-Diphosphoribose-- --target----

    4 Novoseek chemical compound relationships for DHRS11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    17beta-hydroxysteroid 79.7 1 12604235 (1)
    nadph 51.9 2 12604235 (1), 15728189 (1)
    steroid 16.4 1 10668397 (1)
    estrogen 16.1 1 9525918 (1)

    Search CenterWatch for drugs/clinical trials and news about DHRS11 / DHR11 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DHRS11 gene: 
    NM_024308.3  

    Unigene Cluster for DHRS11:

    Dehydrogenase/reductase (SDR family) member 11
    Hs.462859  [show with all ESTs]
    Unigene Representative Sequence: NM_024308
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000251312(uc002hnd.3) ENST00000590554 ENST00000590527 ENST00000394445
    ENST00000491046 ENST00000593204 ENST00000585376 ENST00000586848

    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate DHRS11:
    hsa-miR-130a* hsa-miR-23c hsa-miR-551b* hsa-miR-520a-5p hsa-miR-525-5p hsa-miR-23b hsa-miR-23a hsa-miR-1827
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    Inhib. RNA
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    Additional cDNA sequence: 

    AK026196.1 AK315735.1 AY358712.1 BC002731.2 BC113065.1 CR457356.1 

    13 DOTS entries:

    DT.75110232  DT.455183  DT.92425806  DT.100774904  DT.100023025  DT.100023024  DT.120894125  DT.100774901 
    DT.95375089  DT.100734956  DT.120893898  DT.120894093  DT.95239818 

    24/122 AceView cDNA sequences (see all 122):

    AI129923 BQ278156 CR625650 AI620164 AI699226 BC002731 BM755987 BM674957 
    AK096551 NM_024308 BM682228 BG231973 AI803690 AI422493 BM708058 BM764342 
    BE395404 BE302814 BG324477 AW452081 BM674861 CR592298 AW050632 BM717452 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DHRS11    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
    SP1:                                -                       -               
    SP2:                                -                                       
    SP3:              -                 -                                       
    SP4:                                                                        


    ECgene alternative splicing isoforms for DHRS11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DHRS11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGATCATTA
    DHRS11 Expression
    About this image
    See DHRS11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DHRS11

    SOURCE GeneReport for Unigene cluster: Hs.462859
        SABiosciences Custom PCR Arrays for DHRS11

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHRS11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for DHRS11 gene from 6/29 species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves DHRS111 dehydrogenase/reductase (SDR family) member 11 74.51(n)
    80.39(a)
      395172  NM_204507.1  NP_989838.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.171432 Transcribed sequence with moderate similarity to protein more 75.66(n)    CF221812.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dhrs11a1 dehydrogenase/reductase (SDR family) member 11a 68.89(n)
    74.12(a)
      791578  NM_001100048.1  NP_001093518.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG91501 CG9150 54.36(n)
    44.4(a)
      33856  NM_135147.2  NP_608991.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YMR226C)4
    YMR226C1
    NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, more4
    hypothetical protein1
    42.86(n)1
    31.75(a)1
      13(722396-721593)4
    8552661, 4  NP_013953.11, 4 
    E. coli
    (Escherichia coli)
    Gamma proteobacteria ydfG6
    Malonic semialdehyde reductase, NADPH-dependent; L...
    35(a)
    1 ↔ 1
    Chromosome(1625541-1626287)


    ENSEMBL Gene Tree for DHRS11 (if available)
    TreeFam Gene Tree for DHRS11 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DHRS11 gene
    HPGD2  CBR42  HSD17B82  HSD17B102  
    1 SIMAP similar gene for DHRS11 using alignment to 4 protein entries:     DHR11_HUMAN (see all proteins):
    DHRS4L2

    DHRS11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/159 NCBI SNPs in DHRS11 are shown (see all 159    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs732788401,2
    C,F--34946357(+) AGTGTT/CGATGT 2 -- int1 us2k13Minor allele frequency- C:0.05WA 122
    rs1924325851,2
    --34946422(+) ATGAGA/TATTGA 2 -- us2k1 int10--------
    rs1470239901,2
    --34946502(+) CTTTCC/TCATGA 2 -- us2k1 int10--------
    rs126032761,2
    C,F,A,H--34946547(+) CATAAT/CACAAA 2 -- us2k1 int1 tfbs323Minor allele frequency- C:0.44NS EA NA WA 2354
    rs728183931,2
    C,F--34946601(+) AAACAA/GAACTT 2 -- int1 us2k12Minor allele frequency- G:0.07NA EA 240
    rs1383407861,2
    --34946619(+) TTTCAA/GCCAAG 2 -- int1 us2k10--------
    rs1440842851,2
    --34946642(+) AGTAAC/TTGCTC 2 -- int1 us2k10--------
    rs1169898051,2
    --34946832(+) TGCTGC/TCATTT 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1473353801,2
    --34946852(+) AGTCAA/GATAGC 1 -- us2k10--------
    rs1487650211,2
    --34946861(+) GCTCCA/GTAGAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DHRS11 (34948226 - 34957235 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for DHRS11
         3 CNVs: 3143 2223 8843
         1 Inversion: 37189

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DHRS11 for disorders           About GeneDecksing

    6 diseases for DHRS11:    About MalaCards
    laryngitis    laryngeal carcinoma    pneumonia    tuberculosis
    carcinoma    mycobacterium tuberculosis


    Export disorders for DHRS11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DHRS11 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with DHRS11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
    2. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor. (PubMed id 15728189)9 El Omari K.... Stammers D.K. (2005)
    8. Stereochemical course and steady state mechanism of t he reaction catalyzed by the GDP-fucose synthetase from Escherichia coli. (PubMed id 10480878)9 Menon S....Sullivan F. (1999)
    9. Tic62: a protein family from metabolism to protein translocation. (PubMed id 17374152)9 Balsera M....Bolter B. (2007)
    10. Structural basis of the multispecificity demonstrated by 17beta-hydroxysteroid dehydrogenase types 1 and 5. (PubMed id 16480815)9 Lin S.X....Zhou M. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79154 HGNC: 28639 AceView: MGC4172 Ensembl:ENSG00000108272 euGenes: HUgn79154
    ECgene: DHRS11 H-InvDB: DHRS11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DHRS11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DHRS11 gene:
    Search GeneIP for patents involving DHRS11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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