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Aliases for DHRS11 Gene

Aliases for DHRS11 Gene

  • Dehydrogenase/Reductase (SDR Family) Member 11 2 3 5
  • Short-Chain Dehydrogenase/Reductase Family 24C Member 1 3 4
  • SDR24C1 3 4
  • Short Chain Dehydrogenase/Reductase Family 24C, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 24C 2
  • Inactive Dehydrogenase/Reductase Isoform 3
  • EC 1.1.-.- 4
  • Member 1 2
  • SpDHRS11 3
  • ARPG836 3

External Ids for DHRS11 Gene

Previous GeneCards Identifiers for DHRS11 Gene

  • GC17P032023
  • GC17P034948
  • GC17P030885

Summaries for DHRS11 Gene

GeneCards Summary for DHRS11 Gene

DHRS11 (Dehydrogenase/Reductase (SDR Family) Member 11) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and coenzyme binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS11 Gene

Genomics for DHRS11 Gene

Regulatory Elements for DHRS11 Gene

Promoters for DHRS11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DHRS11 on UCSC Golden Path with GeneCards custom track

Genomic Location for DHRS11 Gene

Chromosome:
17
Start:
36,591,786 bp from pter
End:
36,600,806 bp from pter
Size:
9,021 bases
Orientation:
Plus strand

Genomic View for DHRS11 Gene

Genes around DHRS11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHRS11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHRS11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS11 Gene

Proteins for DHRS11 Gene

  • Protein details for DHRS11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWP2-DHR11_HUMAN
    Recommended name:
    Dehydrogenase/reductase SDR family member 11
    Protein Accession:
    Q6UWP2
    Secondary Accessions:
    • B2RDZ3
    • Q9BUC7
    • Q9H674

    Protein attributes for DHRS11 Gene

    Size:
    260 amino acids
    Molecular mass:
    28308 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for DHRS11 Gene

    Alternative splice isoforms for DHRS11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHRS11 Gene

Proteomics data for DHRS11 Gene at MOPED

Post-translational modifications for DHRS11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHRS11 Gene

No data available for DME Specific Peptides for DHRS11 Gene

Domains & Families for DHRS11 Gene

Gene Families for DHRS11 Gene

Suggested Antigen Peptide Sequences for DHRS11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UWP2

UniProtKB/Swiss-Prot:

DHR11_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS11: view

Function for DHRS11 Gene

Enzyme Numbers (IUBMB) for DHRS11 Gene

genes like me logo Genes that share phenotypes with DHRS11: view

Animal Model Products

CRISPR Products

miRNA for DHRS11 Gene

miRTarBase miRNAs that target DHRS11

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHRS11 Gene

Localization for DHRS11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHRS11 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHRS11 Gene COMPARTMENTS Subcellular localization image for DHRS11 gene
Compartment Confidence
extracellular 4
cytosol 3
golgi apparatus 2
mitochondrion 2
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for DHRS11 Gene

Pathways & Interactions for DHRS11 Gene

SuperPathways for DHRS11 Gene

No Data Available

Interacting Proteins for DHRS11 Gene

Selected Interacting proteins: Q6UWP2-DHR11_HUMAN for DHRS11 Gene via I2D

Gene Ontology (GO) - Biological Process for DHRS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with DHRS11: view

No data available for Pathways by source and SIGNOR curated interactions for DHRS11 Gene

Drugs & Compounds for DHRS11 Gene

(2) Drugs for DHRS11 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2'-Monophosphoadenosine 5'-Diphosphoribose Experimental Pharma Target 0

(3) Additional Compounds for DHRS11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DHRS11: view

Transcripts for DHRS11 Gene

Unigene Clusters for DHRS11 Gene

Dehydrogenase/reductase (SDR family) member 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS11 Gene

No ASD Table

Relevant External Links for DHRS11 Gene

GeneLoc Exon Structure for
DHRS11
ECgene alternative splicing isoforms for
DHRS11

Expression for DHRS11 Gene

mRNA expression in normal human tissues for DHRS11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DHRS11 Gene

This gene is overexpressed in Colon - Transverse (x7.7) and Small Intestine - Terminal Ileum (x5.8).

Protein differential expression in normal tissues from HIPED for DHRS11 Gene

This gene is overexpressed in Pancreatic juice (23.3) and Fetal gut (16.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for DHRS11 Gene



SOURCE GeneReport for Unigene cluster for DHRS11 Gene Hs.462859

genes like me logo Genes that share expression patterns with DHRS11: view

Protein tissue co-expression partners for DHRS11 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DHRS11 Gene

Orthologs for DHRS11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DHRS11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DHRS11 35
  • 91.24 (n)
  • 94.12 (a)
dog
(Canis familiaris)
Mammalia DHRS11 35
  • 90.96 (n)
  • 94.19 (a)
mouse
(Mus musculus)
Mammalia Dhrs11 35
  • 89.49 (n)
  • 92.69 (a)
Dhrs11 16
chimpanzee
(Pan troglodytes)
Mammalia DHRS11 35
  • 99.62 (n)
  • 99.23 (a)
rat
(Rattus norvegicus)
Mammalia Dhrs11 35
  • 90.13 (n)
  • 92.31 (a)
chicken
(Gallus gallus)
Aves DHRS11 35
  • 74.51 (n)
  • 80.39 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17143 35
zebrafish
(Danio rerio)
Actinopterygii dhrs11a 35
  • 68.89 (n)
  • 74.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG40486 35
  • 52.93 (n)
  • 46.35 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B08371g 35
  • 42.9 (n)
  • 32.67 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YMR226C 35
  • 43.16 (n)
  • 32.27 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7104 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08044 35
  • 44.63 (n)
  • 33.88 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC521.03 35
  • 41.87 (n)
  • 31.3 (a)
Species with no ortholog for DHRS11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DHRS11 Gene

ENSEMBL:
Gene Tree for DHRS11 (if available)
TreeFam:
Gene Tree for DHRS11 (if available)

Paralogs for DHRS11 Gene

(1) SIMAP similar genes for DHRS11 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DHRS11: view

No data available for Paralogs for DHRS11 Gene

Variants for DHRS11 Gene

Sequence variations from dbSNP and Humsavar for DHRS11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs875213 -- 36,598,605(+) CCTCT(A/G)CCTGC intron-variant
rs1005551 -- 36,592,931(+) TCAGG(C/T)AGGGA intron-variant
rs1005552 -- 36,593,168(+) GATTC(C/T)GTAAT intron-variant
rs2285638 -- 36,594,931(-) CAGCT(C/G)ACTCC intron-variant
rs2285639 -- 36,594,897(-) ACCCC(A/G)ACCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHRS11 Gene

Variant ID Type Subtype PubMed ID
esv2751645 CNV Gain 17911159
nsv469760 CNV Loss 16826518
essv9000 CNV CNV 17122850
dgv953e1 CNV Complex 17122850

Variation tolerance for DHRS11 Gene

Residual Variation Intolerance Score: 39.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.95; 89.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHRS11 Gene

HapMap Linkage Disequilibrium report
DHRS11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHRS11 Gene

Disorders for DHRS11 Gene

Relevant External Links for DHRS11

Genetic Association Database (GAD)
DHRS11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHRS11

No disorders were found for DHRS11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHRS11 Gene

Publications for DHRS11 Gene

  1. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3 4 67
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Tic62: a protein family from metabolism to protein translocation. (PMID: 17374152) Balsera M. … BAPlter B. (BMC Evol. Biol. 2007) 23
  5. Structural basis of the multispecificity demonstrated by 17beta-hydroxysteroid dehydrogenase types 1 and 5. (PMID: 16480815) Lin S.X. … Zhou M. (Mol. Cell. Endocrinol. 2006) 23

Products for DHRS11 Gene

Sources for DHRS11 Gene

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