Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DHRS11 Gene

Aliases for DHRS11 Gene

  • Dehydrogenase/Reductase 11 2 3 5
  • Short-Chain Dehydrogenase/Reductase Family 24C Member 1 3 4
  • Dehydrogenase/Reductase (SDR Family) Member 11 2 3
  • SDR24C1 3 4
  • Short Chain Dehydrogenase/Reductase Family 24C, Member 1 2
  • Dehydrogenase/Reductase SDR Family Member 11 3
  • Inactive Dehydrogenase/Reductase Isoform 3
  • EC 1.1.-.- 4
  • SpDHRS11 3
  • ARPG836 3

External Ids for DHRS11 Gene

Previous GeneCards Identifiers for DHRS11 Gene

  • GC17P032023
  • GC17P034948
  • GC17P030885

Summaries for DHRS11 Gene

GeneCards Summary for DHRS11 Gene

DHRS11 (Dehydrogenase/Reductase 11) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and coenzyme binding.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS11 Gene

Genomics for DHRS11 Gene

Regulatory Elements for DHRS11 Gene

Enhancers for DHRS11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G036543 1.4 ENCODE dbSUPER 12.2 -46.0 -46007 4.9 HDGF HNRNPUL1 PKNOX1 FOXA2 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNHIT3 MYO19 ENSG00000274756 ENSG00000270871 DHRS11 GGNBP2 GC17P036546
GH17G036589 1.7 FANTOM5 ENCODE dbSUPER 4.6 +4.7 4736 13.7 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 ZNF207 ZNHIT3 MYO19 ENSG00000274756 CCL4L2 DHRS11 GC17P036616 MRM1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DHRS11 on UCSC Golden Path with GeneCards custom track

Promoters for DHRS11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000093591 414 1201 AGO1 SIN3A GLIS2 SP3 SP5 NFYC GLIS1 ETV4 CTCF SAP30

Genomic Location for DHRS11 Gene

Chromosome:
17
Start:
36,591,786 bp from pter
End:
36,600,806 bp from pter
Size:
9,021 bases
Orientation:
Plus strand

Genomic View for DHRS11 Gene

Genes around DHRS11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHRS11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHRS11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS11 Gene

Proteins for DHRS11 Gene

  • Protein details for DHRS11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWP2-DHR11_HUMAN
    Recommended name:
    Dehydrogenase/reductase SDR family member 11
    Protein Accession:
    Q6UWP2
    Secondary Accessions:
    • B2RDZ3
    • Q9BUC7
    • Q9H674

    Protein attributes for DHRS11 Gene

    Size:
    260 amino acids
    Molecular mass:
    28308 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for DHRS11 Gene

    Alternative splice isoforms for DHRS11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHRS11 Gene

Post-translational modifications for DHRS11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHRS11 Gene

No data available for DME Specific Peptides for DHRS11 Gene

Domains & Families for DHRS11 Gene

Gene Families for DHRS11 Gene

Suggested Antigen Peptide Sequences for DHRS11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UWP2

UniProtKB/Swiss-Prot:

DHR11_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS11: view

Function for DHRS11 Gene

Enzyme Numbers (IUBMB) for DHRS11 Gene

Gene Ontology (GO) - Molecular Function for DHRS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with DHRS11: view
genes like me logo Genes that share phenotypes with DHRS11: view

Animal Model Products

CRISPR Products

miRNA for DHRS11 Gene

miRTarBase miRNAs that target DHRS11

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHRS11 Gene

Localization for DHRS11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHRS11 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHRS11 gene
Compartment Confidence
extracellular 4
cytosol 3
mitochondrion 2
golgi apparatus 2
lysosome 1

Gene Ontology (GO) - Cellular Components for DHRS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with DHRS11: view

Pathways & Interactions for DHRS11 Gene

SuperPathways for DHRS11 Gene

No Data Available

Interacting Proteins for DHRS11 Gene

Selected Interacting proteins: Q6UWP2-DHR11_HUMAN for DHRS11 Gene via IID

Gene Ontology (GO) - Biological Process for DHRS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DHRS11: view

No data available for Pathways by source and SIGNOR curated interactions for DHRS11 Gene

Drugs & Compounds for DHRS11 Gene

(2) Drugs for DHRS11 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2'-Monophosphoadenosine 5'-Diphosphoribose Experimental Pharma Target 0

(3) Additional Compounds for DHRS11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DHRS11: view

Transcripts for DHRS11 Gene

Unigene Clusters for DHRS11 Gene

Dehydrogenase/reductase (SDR family) member 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS11 Gene

No ASD Table

Relevant External Links for DHRS11 Gene

GeneLoc Exon Structure for
DHRS11
ECgene alternative splicing isoforms for
DHRS11

Expression for DHRS11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHRS11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DHRS11 Gene

This gene is overexpressed in Colon - Transverse (x7.7) and Small Intestine - Terminal Ileum (x5.8).

Protein differential expression in normal tissues from HIPED for DHRS11 Gene

This gene is overexpressed in Pancreatic juice (23.3) and Fetal gut (16.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DHRS11 Gene



Protein tissue co-expression partners for DHRS11 Gene

NURSA nuclear receptor signaling pathways regulating expression of DHRS11 Gene:

DHRS11

SOURCE GeneReport for Unigene cluster for DHRS11 Gene:

Hs.462859

Evidence on tissue expression from TISSUES for DHRS11 Gene

  • Intestine(4.3)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with DHRS11: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHRS11 Gene

Orthologs for DHRS11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DHRS11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHRS11 34
  • 99.62 (n)
cow
(Bos Taurus)
Mammalia DHRS11 34
  • 91.24 (n)
dog
(Canis familiaris)
Mammalia DHRS11 34
  • 90.96 (n)
rat
(Rattus norvegicus)
Mammalia Dhrs11 34
  • 90.13 (n)
mouse
(Mus musculus)
Mammalia Dhrs11 34 16
  • 89.49 (n)
chicken
(Gallus gallus)
Aves DHRS11 34
  • 74.51 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17143 34
zebrafish
(Danio rerio)
Actinopterygii dhrs11a 34
  • 68.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG40486 34
  • 52.93 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YMR226C 34
  • 43.16 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B08371g 34
  • 42.9 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08044 34
  • 44.63 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC521.03 34
  • 41.87 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7104 34
Species where no ortholog for DHRS11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DHRS11 Gene

ENSEMBL:
Gene Tree for DHRS11 (if available)
TreeFam:
Gene Tree for DHRS11 (if available)

Paralogs for DHRS11 Gene

(1) SIMAP similar genes for DHRS11 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DHRS11: view

No data available for Paralogs for DHRS11 Gene

Variants for DHRS11 Gene

Sequence variations from dbSNP and Humsavar for DHRS11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000369345 -- 36,594,414(+) CCACC(C/G/T)AGGAC intron-variant, upstream-variant-2KB
rs1000396745 -- 36,594,744(+) TCTCC(A/G)TTGAT intron-variant, upstream-variant-2KB
rs1000546280 -- 36,590,670(+) TAGGA(A/G)TGGGG upstream-variant-2KB
rs1000970103 -- 36,593,110(+) CTCAG(A/G)ACCCA intron-variant
rs1001525507 -- 36,593,091(+) TTTAT(C/T)CTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHRS11 Gene

Variant ID Type Subtype PubMed ID
dgv3156n100 CNV gain 25217958
esv2758686 CNV gain+loss 17122850
esv3640471 CNV gain 21293372
esv3640474 CNV gain 21293372
nsv469760 CNV loss 16826518

Variation tolerance for DHRS11 Gene

Residual Variation Intolerance Score: 39.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.95; 89.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHRS11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DHRS11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHRS11 Gene

Disorders for DHRS11 Gene

Relevant External Links for DHRS11

Genetic Association Database (GAD)
DHRS11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHRS11

No disorders were found for DHRS11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHRS11 Gene

Publications for DHRS11 Gene

  1. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3 4 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Human dehydrogenase/reductase (SDR family) member 11 is a novel type of 17I^-hydroxysteroid dehydrogenase. (PMID: 26920053) Endo S. … Ikari A. (Biochem. Biophys. Res. Commun. 2016) 3 64

Products for DHRS11 Gene

Sources for DHRS11 Gene

Content
Loading form....