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Aliases for DHRS11 Gene

Aliases for DHRS11 Gene

  • Dehydrogenase/Reductase (SDR Family) Member 11 2 3
  • Short-Chain Dehydrogenase/Reductase Family 24C Member 1 3 4
  • SDR24C1 3 4
  • Short Chain Dehydrogenase/Reductase Family 24C, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 24C 2
  • Dehydrogenase/Reductase SDR Family Member 11 3
  • Short-Chain Dehydrogenase/Reductase 3
  • EC 1.1.-.- 4
  • Member 1 2
  • ARPG836 3

External Ids for DHRS11 Gene

Previous GeneCards Identifiers for DHRS11 Gene

  • GC17P032023
  • GC17P034948
  • GC17P030885

Summaries for DHRS11 Gene

GeneCards Summary for DHRS11 Gene

DHRS11 (Dehydrogenase/Reductase (SDR Family) Member 11) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS11 Gene

Genomics for DHRS11 Gene

Regulatory Elements for DHRS11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DHRS11 Gene

Start:
36,591,786 bp from pter
End:
36,600,806 bp from pter
Size:
9,021 bases
Orientation:
Plus strand

Genomic View for DHRS11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHRS11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS11 Gene

Proteins for DHRS11 Gene

  • Protein details for DHRS11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWP2-DHR11_HUMAN
    Recommended name:
    Dehydrogenase/reductase SDR family member 11
    Protein Accession:
    Q6UWP2
    Secondary Accessions:
    • B2RDZ3
    • Q9BUC7
    • Q9H674

    Protein attributes for DHRS11 Gene

    Size:
    260 amino acids
    Molecular mass:
    28308 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for DHRS11 Gene

    Alternative splice isoforms for DHRS11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHRS11 Gene

Proteomics data for DHRS11 Gene at MOPED

Post-translational modifications for DHRS11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHRS11 Gene

No data available for DME Specific Peptides for DHRS11 Gene

Domains for DHRS11 Gene

Gene Families for DHRS11 Gene

HGNC:
  • SDRC1 :Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 1

Suggested Antigen Peptide Sequences for DHRS11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UWP2

UniProtKB/Swiss-Prot:

DHR11_HUMAN :
  • Q6UWP2
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS11: view

Function for DHRS11 Gene

Enzyme Numbers (IUBMB) for DHRS11 Gene

Gene Ontology (GO) - Molecular Function for DHRS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0016491 oxidoreductase activity IEA --
GO:0050662 coenzyme binding --
genes like me logo Genes that share ontologies with DHRS11: view

Phenotypes for DHRS11 Gene

GenomeRNAi human phenotypes for DHRS11:
genes like me logo Genes that share phenotypes with DHRS11: view

Animal Model Products

CRISPR Products

miRNA for DHRS11 Gene

miRTarBase miRNAs that target DHRS11

No data available for Molecular function , Animal Models , Transcription Factor Targeting and HOMER Transcription for DHRS11 Gene

Localization for DHRS11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHRS11 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHRS11 Gene COMPARTMENTS Subcellular localization image for DHRS11 gene
Compartment Confidence
extracellular 3
cytosol 2
mitochondrion 2
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for DHRS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with DHRS11: view

Pathways for DHRS11 Gene

SuperPathways for DHRS11 Gene

No Data Available

Interacting Proteins for DHRS11 Gene

Selected Interacting proteins: Q6UWP2-DHR11_HUMAN for DHRS11 Gene via I2D

Gene Ontology (GO) - Biological Process for DHRS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DHRS11: view

No data available for Pathways by source for DHRS11 Gene

Compounds for DHRS11 Gene

(1) Drugbank Compounds for DHRS11 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2'-Monophosphoadenosine 5'-Diphosphoribose
target

(4) Novoseek inferred chemical compound relationships for DHRS11 Gene

Compound -log(P) Hits PubMed IDs
17beta-hydroxysteroid 79.7 1
nadph 51.9 2
steroid 16.4 1
estrogen 16.1 1
genes like me logo Genes that share compounds with DHRS11: view

Transcripts for DHRS11 Gene

Unigene Clusters for DHRS11 Gene

Dehydrogenase/reductase (SDR family) member 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DHRS11

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS11 Gene

No ASD Table

Relevant External Links for DHRS11 Gene

GeneLoc Exon Structure for
DHRS11
ECgene alternative splicing isoforms for
DHRS11

Expression for DHRS11 Gene

mRNA expression in normal human tissues for DHRS11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DHRS11 Gene

This gene is overexpressed in Colon - Transverse (7.7) and Small Intestine - Terminal Ileum (5.8).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for DHRS11 Gene

SOURCE GeneReport for Unigene cluster for DHRS11 Gene Hs.462859

genes like me logo Genes that share expressions with DHRS11: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DHRS11 Gene

Orthologs for DHRS11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DHRS11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHRS11 35
  • 99.62 (n)
  • 99.23 (a)
cow
(Bos Taurus)
Mammalia DHRS11 35
  • 91.24 (n)
  • 94.12 (a)
dog
(Canis familiaris)
Mammalia DHRS11 35
  • 90.96 (n)
  • 94.19 (a)
mouse
(Mus musculus)
Mammalia Dhrs11 35
  • 89.49 (n)
  • 92.69 (a)
Dhrs11 16
rat
(Rattus norvegicus)
Mammalia Dhrs11 35
  • 90.13 (n)
  • 92.31 (a)
chicken
(Gallus gallus)
Aves DHRS11 35
  • 74.51 (n)
  • 80.39 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17143 35
zebrafish
(Danio rerio)
Actinopterygii dhrs11a 35
  • 68.89 (n)
  • 74.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG40486 35
  • 52.93 (n)
  • 46.35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YMR226C 35
  • 43.16 (n)
  • 32.27 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B08371g 35
  • 42.9 (n)
  • 32.67 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08044 35
  • 44.63 (n)
  • 33.88 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC521.03 35
  • 41.87 (n)
  • 31.3 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7104 35
Species with no ortholog for DHRS11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DHRS11 Gene

ENSEMBL:
Gene Tree for DHRS11 (if available)
TreeFam:
Gene Tree for DHRS11 (if available)

Paralogs for DHRS11 Gene

Selected SIMAP similar genes for DHRS11 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DHRS11: view

No data available for Paralogs for DHRS11 Gene

Variants for DHRS11 Gene

Sequence variations from dbSNP and Humsavar for DHRS11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs875213 -- 36,598,605(+) CCTCT(A/G)CCTGC intron-variant
rs1005551 -- 36,592,931(+) TCAGG(C/T)AGGGA intron-variant
rs1005552 -- 36,593,168(+) GATTC(C/T)GTAAT intron-variant
rs2285638 -- 36,594,931(-) CAGCT(C/G)ACTCC intron-variant
rs2285639 -- 36,594,897(-) ACCCC(A/G)ACCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHRS11 Gene

Variant ID Type Subtype PubMed ID
esv2751645 CNV Gain 17911159
nsv469760 CNV Loss 16826518
essv9000 CNV CNV 17122850
dgv953e1 CNV Complex 17122850

Relevant External Links for DHRS11 Gene

HapMap Linkage Disequilibrium report
DHRS11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHRS11 Gene

Disorders for DHRS11 Gene

Relevant External Links for DHRS11

Genetic Association Database (GAD)
DHRS11
genes like me logo Genes that share disorders with DHRS11: view

No data available for UniProtKB/Swiss-Prot for DHRS11 Gene

Publications for DHRS11 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4

Products for DHRS11 Gene

Sources for DHRS11 Gene

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