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Aliases for DHRS1 Gene

Aliases for DHRS1 Gene

  • Dehydrogenase/Reductase (SDR Family) Member 1 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 19C Member 1 3 4
  • SDR19C1 3 4
  • Short Chain Dehydrogenase/Reductase Family 19C, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 19C 2
  • EC 1.1.-.- 4
  • Member 1 2

External Ids for DHRS1 Gene

Previous GeneCards Identifiers for DHRS1 Gene

  • GC14M022132
  • GC14M018547
  • GC14M022749
  • GC14M023829
  • GC14M024759
  • GC14M004874

Summaries for DHRS1 Gene

Entrez Gene Summary for DHRS1 Gene

  • This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded enzyme contains a conserved catalytic domain and likely functions as an oxidoreductase. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]

GeneCards Summary for DHRS1 Gene

DHRS1 (Dehydrogenase/Reductase (SDR Family) Member 1) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity.

Gene Wiki entry for DHRS1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS1 Gene

Genomics for DHRS1 Gene

Regulatory Elements for DHRS1 Gene

Enhancers for DHRS1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DHRS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DHRS1 Gene

24,290,598 bp from pter
24,299,833 bp from pter
9,236 bases
Minus strand

Genomic View for DHRS1 Gene

Genes around DHRS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHRS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHRS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS1 Gene

Proteins for DHRS1 Gene

  • Protein details for DHRS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dehydrogenase/reductase SDR family member 1
    Protein Accession:
    Secondary Accessions:
    • D3DS71
    • Q8NDG3
    • Q96B59
    • Q96CQ5

    Protein attributes for DHRS1 Gene

    313 amino acids
    Molecular mass:
    33909 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DHRS1 Gene

neXtProt entry for DHRS1 Gene

Proteomics data for DHRS1 Gene at MOPED

Post-translational modifications for DHRS1 Gene

  • Ubiquitination at Lys 29 and Lys 217
  • Modification sites at PhosphoSitePlus

Other Protein References for DHRS1 Gene

No data available for DME Specific Peptides for DHRS1 Gene

Domains & Families for DHRS1 Gene

Gene Families for DHRS1 Gene

Suggested Antigen Peptide Sequences for DHRS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS1: view

Function for DHRS1 Gene

Enzyme Numbers (IUBMB) for DHRS1 Gene

Gene Ontology (GO) - Molecular Function for DHRS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with DHRS1: view
genes like me logo Genes that share phenotypes with DHRS1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DHRS1

miRNA for DHRS1 Gene

miRTarBase miRNAs that target DHRS1

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHRS1 Gene

Localization for DHRS1 Gene

Subcellular locations from

Jensen Localization Image for DHRS1 Gene COMPARTMENTS Subcellular localization image for DHRS1 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 3
mitochondrion 3
nucleus 3
cytoskeleton 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DHRS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
genes like me logo Genes that share ontologies with DHRS1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DHRS1 Gene

Pathways & Interactions for DHRS1 Gene

SuperPathways for DHRS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHRS1 Gene


No data available for Pathways by source and SIGNOR curated interactions for DHRS1 Gene

Drugs & Compounds for DHRS1 Gene

No Compound Related Data Available

Transcripts for DHRS1 Gene

Unigene Clusters for DHRS1 Gene

Dehydrogenase/reductase (SDR family) member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: -
SP6: - - - -
SP7: - -
SP9: -

Relevant External Links for DHRS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHRS1 Gene

mRNA expression in normal human tissues for DHRS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DHRS1 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.7) and Liver (x4.4).

Protein differential expression in normal tissues from HIPED for DHRS1 Gene

This gene is overexpressed in Liver (8.4), Nasopharynx (7.7), and Milk (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHRS1 Gene

SOURCE GeneReport for Unigene cluster for DHRS1 Gene Hs.348350

mRNA Expression by UniProt/SwissProt for DHRS1 Gene

Tissue specificity: Detected in heart and liver, and at low levels in skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with DHRS1: view

Protein tissue co-expression partners for DHRS1 Gene

- Elite partner

Primer Products

Orthologs for DHRS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DHRS1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DHRS1 35
  • 85.58 (n)
  • 85.26 (a)
DHRS1 36
  • 85 (a)
(Canis familiaris)
Mammalia DHRS1 35
  • 85.41 (n)
  • 82.37 (a)
DHRS1 36
  • 82 (a)
(Mus musculus)
Mammalia Dhrs1 35
  • 84.13 (n)
  • 82.75 (a)
Dhrs1 16
Dhrs1 36
  • 83 (a)
(Pan troglodytes)
Mammalia DHRS1 35
  • 98.72 (n)
  • 98.08 (a)
DHRS1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Dhrs1 35
  • 84.35 (n)
  • 84.98 (a)
(Monodelphis domestica)
Mammalia DHRS1 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia DHRS1 36
  • 71 (a)
(Anolis carolinensis)
Reptilia DHRS1 36
  • 57 (a)
(Danio rerio)
Actinopterygii dhrs1 35
  • 58.52 (n)
  • 59.28 (a)
dhrs1 36
  • 58 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.316 35
(Caenorhabditis elegans)
Secernentea dhs-9 35
  • 52.32 (n)
  • 49.83 (a)
dhs-26 36
  • 40 (a)
dhs-9 36
  • 46 (a)
F59E11.2 36
  • 42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
-- 36
  • 43 (a)
Species with no ortholog for DHRS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DHRS1 Gene

Gene Tree for DHRS1 (if available)
Gene Tree for DHRS1 (if available)

Paralogs for DHRS1 Gene

No data available for Paralogs for DHRS1 Gene

Variants for DHRS1 Gene

Sequence variations from dbSNP and Humsavar for DHRS1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_052318 -

Structural Variations from Database of Genomic Variants (DGV) for DHRS1 Gene

Variant ID Type Subtype PubMed ID
esv2669637 CNV Deletion 23128226
dgv1855n71 CNV Loss 21882294

Variation tolerance for DHRS1 Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.36; 70.92% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DHRS1 Gene

Disorders for DHRS1 Gene

Relevant External Links for DHRS1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DHRS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHRS1 Gene

Publications for DHRS1 Gene

  1. Molecular cloning and characterization of a novel dehydrogenase/reductase (SDR family) member 1 gene from human fetal brain. (PMID: 12153138) Wu Q. … Mao Y. (Mol. Biol. Rep. 2001) 2 3 4 23 67
  2. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3
  3. Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment. (PMID: 24571439) Nudel R. … Newbury D.F. (Genes Brain Behav. 2014) 3
  4. Multivariate sequence analysis reveals additional function impacting residues in the SDR superfamily. (PMID: 25052469) Tiwari P. … Choudhury D. (Proteins 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for DHRS1 Gene

Sources for DHRS1 Gene