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Aliases for DHPS Gene

Aliases for DHPS Gene

  • Deoxyhypusine Synthase 2 3 5
  • Migration-Inducing Gene 13 2 3
  • EC 2.5.1.46 4 61
  • DHS 3 4
  • DS 3 4
  • EC 2.5.1 61
  • MIG13 3

External Ids for DHPS Gene

Previous GeneCards Identifiers for DHPS Gene

  • GC19M012917
  • GC19M013009
  • GC19M012631
  • GC19M012647
  • GC19M012786
  • GC19M012359

Summaries for DHPS Gene

Entrez Gene Summary for DHPS Gene

  • This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for DHPS Gene

DHPS (Deoxyhypusine Synthase) is a Protein Coding gene. Diseases associated with DHPS include Pneumocystosis and Plasmodium Falciparum Malaria. Among its related pathways are Gamma carboxylation, hypusine formation and arylsulfatase activation and Metabolism of proteins. GO annotations related to this gene include deoxyhypusine synthase activity.

UniProtKB/Swiss-Prot for DHPS Gene

  • Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

Gene Wiki entry for DHPS Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHPS Gene

Genomics for DHPS Gene

Regulatory Elements for DHPS Gene

Enhancers for DHPS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G012680 1.2 ENCODE 0.7 +0.2 231 1.8 CREB3L1 AGO1 DMAP1 YY1 ZNF143 ZNF548 SP3 NFYC TBX21 ZNF610 ZNF136 ZNF564 ZNF791 ZNF44 ZNF442 ZNF700 WDR83OS ZNF799 TRMT1 ZNF844
GH19G012672 1 ENCODE 0.4 +9.7 9711 0.2 HDGF ATF1 ARNT AGO1 ARID4B E2F7 SIN3A ZNF2 GLIS2 ELK1 ZNF44 WDR83OS ZNF700 TRMT1 ZNF564 ZNF136 ZNF791 ZNF440 ZNF878 ZNF799
GH19G012675 0.9 ENCODE 0.4 +5.6 5623 1.9 HNRNPUL1 HDGF CBX3 ZNF2 ZBTB7B RAD21 ZNF121 GLIS2 ZNF143 RELB WDR83OS ZNF763 DHPS
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DHPS on UCSC Golden Path with GeneCards custom track

Promoters for DHPS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107287 302 1601 CREB3L1 AGO1 DMAP1 YY1 ZNF143 ZNF548 SP3 NFYC MEF2D ZNF610

Genomic Location for DHPS Gene

Chromosome:
19
Start:
12,672,858 bp from pter
End:
12,681,902 bp from pter
Size:
9,045 bases
Orientation:
Minus strand

Genomic View for DHPS Gene

Genes around DHPS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHPS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHPS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHPS Gene

Proteins for DHPS Gene

  • Protein details for DHPS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49366-DHYS_HUMAN
    Recommended name:
    Deoxyhypusine synthase
    Protein Accession:
    P49366
    Secondary Accessions:
    • A8K688
    • M0R1I5
    • Q13184
    • Q13276
    • Q9UDG0

    Protein attributes for DHPS Gene

    Size:
    369 amino acids
    Molecular mass:
    40971 Da
    Cofactor:
    Name=NAD(+); Xref=ChEBI:CHEBI:57540;
    Quaternary structure:
    • Homotetramer formed by a dimer of dimers.
    SequenceCaution:
    • Sequence=AL520040; Type=Frameshift; Positions=329, 344, 355; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DHPS Gene

    Alternative splice isoforms for DHPS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHPS Gene

Selected DME Specific Peptides for DHPS Gene

P49366:
  • KHHIANA
  • QEFDGSD
  • TAGGVEED
  • EAVSWGK
  • MPILDQM
  • LTDGSLGDM
  • RYLVQHNMV
  • TSNLISSG
  • GARPDEA
  • LVAETFA
  • GINRIGN
  • FEDWLMPILD
  • NRIGNLLVPN
  • EEDLIKCL
  • IRYLVQH
  • RNGADYA
  • RLGKEIN
  • IKCLAPT
  • FLGYTSN
  • GMIILGGG
  • LMRNGADYAVYINT

Post-translational modifications for DHPS Gene

  • Ubiquitination at isoforms=219, isoforms=3, 2212, Lys329, and Lys366
  • Modification sites at PhosphoSitePlus

Domains & Families for DHPS Gene

Protein Domains for DHPS Gene

Suggested Antigen Peptide Sequences for DHPS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49366

UniProtKB/Swiss-Prot:

DHYS_HUMAN :
  • Belongs to the deoxyhypusine synthase family.
Family:
  • Belongs to the deoxyhypusine synthase family.
genes like me logo Genes that share domains with DHPS: view

No data available for Gene Families for DHPS Gene

Function for DHPS Gene

Molecular function for DHPS Gene

GENATLAS Biochemistry:
deoxyhypusine synthase,required for the post-translational formation of hypusine by modification of a specific residue in eucaryotic initiation factor 5A (EI5FA),pivotal in cell proliferation
UniProtKB/Swiss-Prot CatalyticActivity:
[eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.
UniProtKB/Swiss-Prot Function:
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

Enzyme Numbers (IUBMB) for DHPS Gene

Gene Ontology (GO) - Molecular Function for DHPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14622290
GO:0016740 transferase activity IEA --
GO:0034038 deoxyhypusine synthase activity EXP,IDA 23525104
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with DHPS: view
genes like me logo Genes that share phenotypes with DHPS: view

Animal Models for DHPS Gene

MGI Knock Outs for DHPS:

Animal Model Products

CRISPR Products

miRNA for DHPS Gene

miRTarBase miRNAs that target DHPS

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DHPS Gene

Localization for DHPS Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHPS gene
Compartment Confidence
cytosol 5
cytoskeleton 3
nucleus 3
plasma membrane 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DHPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DHPS: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DHPS Gene

Pathways & Interactions for DHPS Gene

genes like me logo Genes that share pathways with DHPS: view

UniProtKB/Swiss-Prot P49366-DHYS_HUMAN

  • Pathway: Protein modification; eIF5A hypusination.

Gene Ontology (GO) - Biological Process for DHPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS 7673224
GO:0008216 spermidine metabolic process IDA 23525104
GO:0008284 positive regulation of cell proliferation TAS 8549832
GO:0008612 peptidyl-lysine modification to peptidyl-hypusine TAS,IEA --
GO:0042102 positive regulation of T cell proliferation IEA --
genes like me logo Genes that share ontologies with DHPS: view

No data available for SIGNOR curated interactions for DHPS Gene

Drugs & Compounds for DHPS Gene

(19) Drugs for DHPS Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
spermidine Experimental Pharma Antagonist, Pore Blocker 0
1-Guanidinium-7-Aminoheptane Experimental Pharma Target, inhibitor 0
NAD Pharma Full agonist, Agonist 0

(19) Additional Compounds for DHPS Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1,3-diaminopropane
  • 1,3-Diamino-N-propane
  • 1,3-Propanediamine
  • 1,3-Propylenediamine
  • 1,3-Trimethylenediamine
  • 3-Aminopropylamine
109-76-2
deoxyhypusine
  • N(6)-(4-Aminobutyl)-L-lysine
  • N(6)-(4-Aminobutyl)lysine
82543-85-9
genes like me logo Genes that share compounds with DHPS: view

Transcripts for DHPS Gene

Unigene Clusters for DHPS Gene

Deoxyhypusine synthase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHPS Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^
SP1: - - - - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - -
SP6: - -
SP7: - - - - - -
SP8: - - - - - -
SP9: - - - - -
SP10: -
SP11: - -
SP12:
SP13: - - - - - - -
SP14: - - - -
SP15: - - - - - -
SP16: -

ExUns: 11 ^ 12
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for DHPS Gene

GeneLoc Exon Structure for
DHPS
ECgene alternative splicing isoforms for
DHPS

Expression for DHPS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHPS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DHPS Gene

This gene is overexpressed in Lung (16.2), Retina (6.8), Tonsil (6.7), and Testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DHPS Gene



Protein tissue co-expression partners for DHPS Gene

NURSA nuclear receptor signaling pathways regulating expression of DHPS Gene:

DHPS

SOURCE GeneReport for Unigene cluster for DHPS Gene:

Hs.79064

Evidence on tissue expression from TISSUES for DHPS Gene

  • Nervous system(4.9)
  • Lung(4.5)
  • Blood(4.3)
  • Eye(2.4)
  • Muscle(2.4)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with DHPS: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHPS Gene

Orthologs for DHPS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHPS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHPS 34 35
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia DHPS 34 35
  • 89.43 (n)
cow
(Bos Taurus)
Mammalia DHPS 34 35
  • 88.62 (n)
rat
(Rattus norvegicus)
Mammalia Dhps 34
  • 87.26 (n)
mouse
(Mus musculus)
Mammalia Dhps 34 16 35
  • 87.08 (n)
oppossum
(Monodelphis domestica)
Mammalia DHPS 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DHPS 35
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHPS 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhps 34
  • 69.79 (n)
MGC76269 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.11626 34
zebrafish
(Danio rerio)
Actinopterygii DHPS (2 of 2) 35
  • 82 (a)
OneToMany
dhps 34 35
  • 72.53 (n)
wufb52g04 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9614 34
fruit fly
(Drosophila melanogaster)
Insecta CG8005 36 34 35
  • 65.14 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006531 34
  • 62.94 (n)
worm
(Caenorhabditis elegans)
Secernentea Y17G7B.4 36
  • 58 (a)
dhps-1 34 35
  • 56.63 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL036W 34
  • 60.69 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DYS1 34 35 37
  • 59.31 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E12695g 34
  • 57.63 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons DHS 34
  • 59.56 (n)
soybean
(Glycine max)
eudicotyledons Gma.5453 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6077 34
rice
(Oryza sativa)
Liliopsida Os03g0740600 34
  • 61.33 (n)
Os.33154 34
corn
(Zea mays)
Liliopsida Zm.12010 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7280 35
  • 64 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU05418 34
  • 61.49 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1271.04c 34
  • 59.04 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12482 34
Species where no ortholog for DHPS was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHPS Gene

ENSEMBL:
Gene Tree for DHPS (if available)
TreeFam:
Gene Tree for DHPS (if available)

Paralogs for DHPS Gene

No data available for Paralogs for DHPS Gene

Variants for DHPS Gene

Sequence variations from dbSNP and Humsavar for DHPS Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000133427 -- 12,678,027(+) GCGGG(G/T)GGATC intron-variant
rs1000217733 -- 12,682,860(+) CAGGC(C/G)TGGCT upstream-variant-2KB
rs1000308722 -- 12,678,753(+) GACAG(A/T)GCAAG intron-variant
rs1000433971 -- 12,682,965(+) AGATT(A/C)CAGGT upstream-variant-2KB
rs1000465152 -- 12,683,124(+) GTTTG(C/T)TTGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DHPS Gene

Variant ID Type Subtype PubMed ID
dgv138n111 CNV deletion 26073780
nsv1160586 CNV duplication 26073780
nsv953977 CNV deletion 24416366

Variation tolerance for DHPS Gene

Residual Variation Intolerance Score: 18.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.78; 58.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHPS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DHPS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHPS Gene

Disorders for DHPS Gene

MalaCards: The human disease database

(5) MalaCards diseases for DHPS Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pneumocystosis
  • pneumocystis carinii pneumonia
plasmodium falciparum malaria
  • falciparum malaria
malaria
  • malaria, severe
meningococcal meningitis
  • meningitis meningococcal
neisseria meningitidis infection
  • meningococcal disease
- elite association - COSMIC cancer census association via MalaCards
Search DHPS in MalaCards View complete list of genes associated with diseases

Relevant External Links for DHPS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHPS
genes like me logo Genes that share disorders with DHPS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DHPS Gene

Publications for DHPS Gene

  1. Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins. (PMID: 7673224) Joe Y.A. … Park M.H. (J. Biol. Chem. 1995) 2 3 4 22 64
  2. A new crystal structure of deoxyhypusine synthase reveals the configuration of the active enzyme and of an enzyme.NAD.inhibitor ternary complex. (PMID: 15100216) Umland T.C. … Davies D.R. (J. Biol. Chem. 2004) 3 4 22 64
  3. Reversal of the deoxyhypusine synthesis reaction. Generation of spermidine or homospermidine from deoxyhypusine by deoxyhypusine synthase. (PMID: 12788913) Park J.H. … Park M.H. (J. Biol. Chem. 2003) 3 22 25 64
  4. Localization and genomic structure of human deoxyhypusine synthase gene on chromosome 19p13.2-distal 19p13.1. (PMID: 9666110) Mantuano E. … Jodice C. (Gene 1998) 3 4 22 64
  5. Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site. (PMID: 9493264) Liao D.-I. … Davies D.R. (Structure 1998) 3 4 22 64

Products for DHPS Gene

Sources for DHPS Gene

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