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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DHPS Gene

protein-coding   GIFtS: 60
GCID: GC19M012786

deoxyhypusine synthase
 Explore 16 diseases affiliated with
DHPS via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DHPS    

Aliases
for DHPS gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Deoxyhypusine Synthase1 2     EC 2.5.1.463 8
MIG131 2     Migration-Inducing Gene 132
DHS2 3     EC 2.5.18
DS2 3     

External Ids:    HGNC: 28691   Entrez Gene: 17252   Ensembl: ENSG000000950597   OMIM: 6009445   UniProtKB: P493663   
ORGUL members:         
NONCODE:n410743    

Export aliases for DHPS gene to outside databases

Previous GC identifers: GC19M012917 GC19M013009 GC19M012631 GC19M012647 GC19M012359


Summaries
for DHPS gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DHPS:
This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the
posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein
catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific
lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine
residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
(provided by RefSeq, May 2011)

UniProtKB/Swiss-Prot: DHYS_HUMAN, P49366
Function: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine
moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form
the intermediate deoxyhypusine residue

Gene Wiki entry for DHPS


Genomic Views
for DHPS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DHPS gene promoter:
         C/EBPbeta   NF-1/L   NF-1   p53   CUTL1   Nkx5-1   GATA-1   Evi-1   Pax-3   HOXA5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DHPS promoter sequence
   Search SABiosciences Chromatin IP Primers for DHPS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHPS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

DHPS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHPS gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M012786:  view genomic region     (about GC identifiers)

Start:
 12,786,534 bp from pter      End:
 12,792,682 bp from pter
Size:
 6,149 bases      Orientation:
 minus strand

Proteins
for DHPS gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DHYS_HUMAN, P49366 (See protein sequence)
Recommended Name: Deoxyhypusine synthase  
Size: 369 amino acids; 40971 Da
Cofactor: NAD
Subunit: Homotetramer formed by a dimer of dimers
4 PDB 3D structures from and Proteopedia for DHPS:
1DHS (3D)        1RLZ (3D)        1ROZ (3D)        1RQD (3D)    
Secondary accessions: A8K688 Q13184 Q13276 Q9UDG0
Alternative splicing: 2 isoforms:  P49366-1   P49366-2   (Inactive)

Explore the universe of human proteins at neXtProt for DHPS: NX_P49366

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P49366

    • 4/21 DME Specific Peptides for DHPS (P49366) (see all 21)
     IRYLVQH  LVAETFA  RNGADYA  GINRIGN 

    DHPS Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001193903.1  NP_001921.1  NP_037538.1  

    ENSEMBL proteins: 
     ENSP00000210060   ENSP00000221303  
    Reactome Protein details: P49366
    Human Recombinant Protein Products: 
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    Uscn Proteins for DHPS

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--


    DHPS for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DHPS

    Protein Domains /
    Families
    for DHPS gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DHPS for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002773 Deoxyhypusine_synthase

    Graphical View of Domain Structure for InterPro Entry P49366

    ProtoNet protein and cluster: P49366

    1 Blocks protein family: IPB002773 Deoxyhypusine synthase

    UniProtKB/Swiss-Prot: DHYS_HUMAN, P49366
    Similarity: Belongs to the deoxyhypusine synthase family


    Function
    for DHPS gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DHYS_HUMAN, P49366
    Function: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine
    moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form
    the intermediate deoxyhypusine residue
    Catalytic activity: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine

         Genatlas biochemistry entry for DHPS:
    deoxyhypusine synthase,required for the post-translational formation of hypusine by modification of a specific residue
    in eucaryotic initiation factor 5A (EI5FA),pivotal in cell proliferation

    Enzyme Numbers (IUBMB): EC 2.5.1.461 2 EC 2.5.12

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate DHPS:
    hsa-miR-3121-3p
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    Inhib. RNA
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19060904
    GO:0034038deoxyhypusine synthase activity TAS--


    DHPS for ontologies           About GeneDecksing



    Pathways & Interactions
    for DHPS gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1hypusine biosynthesis
    		hypusine biosynthesis1.00
    		Hypusine synthesis from eIF5A-lysine0.50
    2Asparagine N-linked glycosylation
    		Post-translational protein modification0.44
    		Metabolism of proteins0.15
    3PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
    		PTM: gamma carboxylation, hypusine formation and arylsulfatase activation1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for DHPS 
        hypusine biosynthesis

    4        Reactome Pathways for DHPS
        Hypusine synthesis from eIF5A-lysine
    Metabolism of proteins
    Post-translational protein modification
    PTM: gamma carboxylation, hypusine formation and arylsulfatase activation


    UniProtKB/Swiss-Prot: DHYS_HUMAN, P49366
    Pathway: Protein modification; eIF5A hypusination


    DHPS for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DHPS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/54 Interacting proteins for DHPS (P493661, 2, 3 ENSP000002100604) via UniProtKB, MINT, STRING, and/or I2D (see all 54)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL9P329692, 3, ENSP000003460224MINT-67227 I2D: score=5 STRING: ENSP00000346022
    RPL9P7P329692, 3MINT-67227 I2D: score=5 
    RPL9P8P329692, 3MINT-67227 I2D: score=5 
    RPL9P9P329692, 3MINT-67227 I2D: score=5 
    NUDT18Q6ZVK81, 2, 3, ENSP000003078524EBI-741925,EBI-954151 MINT-66764 I2D: score=5 STRING: ENSP00000307852
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS7673224
    GO:0008284positive regulation of cell proliferation TAS8549832
    GO:0008612peptidyl-lysine modification to hypusine TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--


    DHPS for ontologies           About GeneDecksing



    Drugs & Compounds
    for DHPS gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DHPS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DHPS

    7 HMDB Compounds for DHPS    About this table
    CompoundSynonyms CAS #PubMed Ids
    1,3-Diaminopropane1,3-Diamino-n-propane (see all 8)109-76-2--
    1-pyrrolinePyr1 5724-81-2--
    DehydrospermidineN,C-di(3-aminopropyl)-imine;N-(4-aminobutylidene)-N-(3-aminopropyl)amine ----
    DeoxyhypusineN(6)-(4-Aminobutyl)lysine (see all 2)82543-85-9--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Spermidine1,5,10-Triazadecane (see all 15)124-20-9--

    2 DrugBank Compounds for DHPS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-Guanidinium-7-Aminoheptane-- --targetinhibitor17139284 11752352 17016423 10592235
    Nicotinamide-Adenine-Dinucleotide-- 53-84-9target--17139284 17016423

    10/36 Novoseek chemical compound relationships for DHPS gene (see all 36)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dihydropteroate 98.7 136 11055650 (2), 19246797 (2), 17134675 (2), 9735930 (2) (see all 99)
    deoxyhypusine 98.5 240 14749535 (10), 11098085 (7), 15100216 (7), 10229683 (6) (see all 65)
    hypusine 97.5 49 16371467 (2), 17476569 (2), 10630376 (1), 7750572 (1) (see all 35)
    sulfadoxine 95.1 39 10722502 (3), 16517168 (2), 9391510 (2), 9735930 (2) (see all 32)
    sulfadoxine/pyrimethamine 93.1 79 16023986 (5), 12805261 (4), 11675058 (3), 15642967 (3) (see all 32)
    pyrimethamine 92.9 31 10722502 (3), 12805261 (2), 9735930 (2), 11846521 (1) (see all 26)
    dihydrofolate 91.2 70 9735930 (2), 8780462 (1), 10432070 (1), 10466980 (1) (see all 68)
    homospermidine 86.2 15 12620346 (4), 12788913 (3), 11197320 (1), 19254800 (1) (see all 6)
    fansidar 79.6 7 11280065 (4), 12685644 (1), 10461838 (1), 9364963 (1)
    amodiaquine 79.3 6 19194499 (1), 15642967 (1), 18337343 (1)

    Search CenterWatch for drugs/clinical trials and news about DHPS / DHYS 

    Transcripts
    for DHPS gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DHPS gene (4 alternative transcripts): 
    NM_001206974.1  NM_001930.3  NM_013406.2  NM_013407.1  

    Unigene Cluster for DHPS:

    Deoxyhypusine synthase
    Hs.79064  [show with all ESTs]
    Unigene Representative Sequence: BC014016
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000210060(uc002mug.2 uc002muh.2 uc002muk.2 uc010xmn.2)
    ENST00000351660(uc002mui.2)

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    hsa-miR-3121-3p
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    Additional cDNA sequence: 

    AK291553.1 AK300498.1 AK304780.1 AY336090.1 BC000333.2 BC014016.2 BC128553.1 L39068.1 
    NR_038192.1 U26266.1 U32178.1 U40579.1 U79262.1 

    24/27 DOTS entries (see all 27):

    DT.100868756  DT.75176677  DT.95154402  DT.95224094  DT.95154416  DT.75109309  DT.446116  DT.100868752 
    DT.100805888  DT.121449149  DT.95375288  DT.95154393  DT.100868762  DT.97860016  DT.100637802  DT.100868747 
    DT.92444614  DT.100868748  DT.121449443  DT.92037633  DT.92444624  DT.121449337  DT.100038902  DT.100868753 

    24/339 AceView cDNA sequences (see all 339):

    CR592989 BM829442 BQ083299 CR625197 CR611147 CR622825 BM829382 CR601991 
    BE741469 AU138112 CD625011 AU104785 CR612211 BE892642 BF436614 CA411945 
    BQ686975 BU844677 BF940778 BM917458 BQ888458 BE793652 NM_001930 BX402820 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for DHPS (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^
    SP1:                                -     -     -                       -     -                                   -                             -     -     -   
    SP2:                                -     -     -                       -     -                                   -                                         -   
    SP3:                                                                    -     -                                   -                                         -   
    SP4:                                                                    -     -                                   -                                         -   
    SP5:                                                                    -     -                                   -                                             

    ExUns: 11 ^ 12
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for DHPS

    Expression
    for DHPS gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DHPS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGAAGAACGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See DHPS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DHPS

    SOURCE GeneReport for Unigene cluster: Hs.79064
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    In Situ
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    Orthologs
    for DHPS gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DHPS gene from 9/40 species (see all 40)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dhps1 , 5 deoxyhypusine synthase1, 5 87.08(n)1
    91.33(a)1    		   8 (41.55 cM)5
    3308171  NM_001039514.11  NP_001034603.11 
     850717575 
    lizard
    (Anolis carolinensis)    		 Reptilia DHPS6
    		 --
    		 80(a)
    		 1 ↔ 1
    		 3(92234536-92242057)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.116262 Xenopus laevis transcribed sequence with weak similarity more 75.66(n)    CA982532.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb52g042 Danio rerio mRNA similar to deoxyhypusine synthase more 76.63(n)    BC047806.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG80051 , 3 hypusine biosynthesis from peptidyl-lysine
    deoxyhypusine more3
    CG80051    		 64(a)3
    65.14(n)1
    64.18(a)1    		   66B123
    389171  NM_139931.21  NP_648188.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y17G7B.43
    dhps-11    		 Protein DHPS-11 58(a)3
    56.63(n)1
    59.94(a)1    		   II(11992867-11995401)3
    1748401  NM_064156.21  NP_496557.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes DYS1(YHR068W)4
    DYS11    		 Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, more4
    Dys1p1    		 59.12(n)1
    61.76(a)1    		   8(232133-233296)4
    8564651, 4  NP_011935.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons DHS1 deoxyhypusine synthase 59.56(n)
    62.78(a)    		   830477  NM_120674.3  NP_196211.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.331542 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.54(n)    AK073852.1 


    ENSEMBL Gene Tree for DHPS (if available)
    TreeFam Gene Tree for DHPS (if available) 

    Paralogs
    for DHPS gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for DHPS gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/215 NCBI SNPs in DHPS are shown (see all 215)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs178510851,2
    		C--12359696(+) TCCTCG/ATTCTT 3 -- ds50011Minor allele frequency- A:0.00NA 2
    rs617308411,2
    		C,F--12359769(+) GGGAGA/C/GCGTCA 3 -- ds50012NS NA 4614
    rs104100271,2
    		C,F,H,--12360137(+) CAGGGC/TCCATG 3 -- ds50019Minor allele frequency- T:0.01NS EA NA WA 1206
    rs1881468741,2
    		--12786039(+) AGTTCC/GAGACC 7 -- ds5001 int10--------
    rs1916242051,2
    		--12786083(+) TATTTC/TAAAAA 7 -- int1 ds50010--------
    rs1458371751,2
    		--12786183(+) TTTTGC/GAGTGT 7 -- int1 ds50010--------
    rs1824289431,2
    		--12786200(+) GGCAAC/TTAGAG 7 -- ds5001 int10--------
    rs1485567941,2
    		--12786222(+) AAGGTC/TGGGGA 7 -- ds5001 int10--------
    rs1874262481,2
    		--12786223(+) AGGTCA/GGGGAG 7 -- int1 ds50010--------
    rs1999540871,2
    		--12786517(+) AAGGAC/TCGAGA 7 -- ds5001 nc-transcript-variantut310--------

    HapMap Linkage Disequilibrium report for DHPS (12786534 - 12792682 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DHPS: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DHPS
    DNA2.0 Custom Variant and Variant Library Synthesis for DHPS

    Disorders / Diseases
    for DHPS gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DHPS for disorders           About GeneDecksing

    OMIM gene information: 600944    OMIM disorders: --

    16 diseases for DHPS:    About MalaCards
    plasmodium falciparum malaria    whipple disease    pneumocystosis    bronchiolitis
    meningitis    bronchitis    toxoplasmosis    pneumonia
    hepatocellular carcinoma    malaria    tuberculosis    immunodeficiency
    neuroblastoma    carcinoma    neuronitis    mycobacterium tuberculosis

    10/12 Novoseek disease relationships for DHPS gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    malaria falciparum 82.3 7 19055622 (2), 10466980 (1), 16124424 (1), 12533279 (1) (see all 6)
    malaria 78.3 26 17042947 (3), 16023986 (2), 10722502 (1), 16159551 (1) (see all 18)
    pneumonia pneumocystis carinii 75.8 10 19085210 (1), 14736212 (1), 11055650 (1), 15175932 (1) (see all 10)
    pneumonia 52.5 17 11520525 (2), 12890330 (1), 15504261 (1), 15175932 (1) (see all 14)
    parasitemia 45.2 2 19451638 (1), 20439953 (1)
    bronchiolitis 26.3 1 14736212 (1)
    aids 25.6 9 10915088 (2), 9631140 (2), 12890330 (1), 11992293 (1) (see all 7)
    immunodeficiency 22.5 3 7687120 (1), 10979917 (1), 15472859 (1)
    meningococcal diseases 15 1 9705404 (1)
    cancer 3.44 2 11098085 (1), 15296643 (1)


    Export disorders for DHPS gene to outside databases

    Publications
    for DHPS gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DHPS gene, integrated from 9 sources (see all 259):
    (articles sorted by number of sources associating them with DHPS)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins. (PubMed id 7673224)1, 2, 3, 9 Joe Y.A.... Park M.H. (1995)
    2. A new crystal structure of deoxyhypusine synthase reveals the configuration of the active enzyme and of an enzyme.NAD.inhibitor ternary complex. (PubMed id 15100216)1, 2, 9 Umland T.C....Davies D.R. (2004)
    3. Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site. (PubMed id 9493264)1, 2, 9 Liao D.-I.... Davies D.R. (1998)
    4. Molecular characterization of a cDNA encoding functional human deoxyhypusine synthase and chromosomal mapping of the corresponding gene locus. (PubMed id 8549832)1, 2, 9 Bevec D....Steinkasserer A. (1996)
    5. Purification and characterization of human deoxyhypusine synthase from HeLa cells. (PubMed id 7750572)1, 2, 9 Klier H....Eder J. (1995)
    6. Localization and genomic structure of human deoxyhypusine synthase gene on chromosome 19p13.2-distal 19p13.1. (PubMed id 9666110)1, 2, 9 Mantuano E....Jodice C. (1998)
    7. Molecular cloning and functional expression of human deoxyhypusine synthase cDNA based on expressed sequence tag information. (PubMed id 8615810)1, 2, 9 Yan Y.P.... Chen K.Y. (1996)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 2 Yu W.... Gibbs R.A. (1997)
    10. Protein kinase CK2 phosphorylates and interacts with deoxyhypusine synthase in HeLa cells. (PubMed id 14749535)1, 9 Kang K.R. and Chung S.I. (2003)

    External Searches for DHPS gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DHPS gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1725 HGNC: 2869 AceView: DHPS Ensembl:ENSG00000095059 euGenes: HUgn1725
    ECgene: DHPS H-InvDB: DHPS

    Other Databases showing DHPS gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DHPS gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DHPS Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DHPS gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DHPS gene:
    Search GeneIP for patents involving DHPS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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