Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DHPS Gene

Aliases for DHPS Gene

  • Deoxyhypusine Synthase 2 3 5
  • Migration-Inducing Gene 13 2 3
  • EC 2.5.1.46 4 63
  • DHS 3 4
  • DS 3 4
  • EC 2.5.1 63
  • MIG13 3

External Ids for DHPS Gene

Previous GeneCards Identifiers for DHPS Gene

  • GC19M012917
  • GC19M013009
  • GC19M012631
  • GC19M012647
  • GC19M012786
  • GC19M012359

Summaries for DHPS Gene

Entrez Gene Summary for DHPS Gene

  • This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for DHPS Gene

DHPS (Deoxyhypusine Synthase) is a Protein Coding gene. Diseases associated with DHPS include Pneumocystosis and Malaria. Among its related pathways are Gamma carboxylation, hypusine formation and arylsulfatase activation and Transport to the Golgi and subsequent modification. GO annotations related to this gene include deoxyhypusine synthase activity.

UniProtKB/Swiss-Prot for DHPS Gene

  • Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

Gene Wiki entry for DHPS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHPS Gene

Genomics for DHPS Gene

Regulatory Elements for DHPS Gene

Enhancers for DHPS Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DHPS on UCSC Golden Path with GeneCards custom track

Promoters for DHPS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DHPS on UCSC Golden Path with GeneCards custom track

Genomic Location for DHPS Gene

Chromosome:
19
Start:
12,672,858 bp from pter
End:
12,681,902 bp from pter
Size:
9,045 bases
Orientation:
Minus strand

Genomic View for DHPS Gene

Genes around DHPS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHPS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHPS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHPS Gene

Proteins for DHPS Gene

  • Protein details for DHPS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49366-DHYS_HUMAN
    Recommended name:
    Deoxyhypusine synthase
    Protein Accession:
    P49366
    Secondary Accessions:
    • A8K688
    • M0R1I5
    • Q13184
    • Q13276
    • Q9UDG0

    Protein attributes for DHPS Gene

    Size:
    369 amino acids
    Molecular mass:
    40971 Da
    Cofactor:
    Name=NAD(+); Xref=ChEBI:CHEBI:57540;
    Quaternary structure:
    • Homotetramer formed by a dimer of dimers.
    SequenceCaution:
    • Sequence=AL520040; Type=Frameshift; Positions=329, 344, 355; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DHPS Gene

    Alternative splice isoforms for DHPS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHPS Gene

Proteomics data for DHPS Gene at MOPED

Post-translational modifications for DHPS Gene

  • Ubiquitination at Lys 19, Lys 212, Lys 329, and Lys 366
  • Modification sites at PhosphoSitePlus

Domains & Families for DHPS Gene

Protein Domains for DHPS Gene

Suggested Antigen Peptide Sequences for DHPS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49366

UniProtKB/Swiss-Prot:

DHYS_HUMAN :
  • Belongs to the deoxyhypusine synthase family.
Family:
  • Belongs to the deoxyhypusine synthase family.
genes like me logo Genes that share domains with DHPS: view

No data available for Gene Families for DHPS Gene

Function for DHPS Gene

Molecular function for DHPS Gene

GENATLAS Biochemistry:
deoxyhypusine synthase,required for the post-translational formation of hypusine by modification of a specific residue in eucaryotic initiation factor 5A (EI5FA),pivotal in cell proliferation
UniProtKB/Swiss-Prot CatalyticActivity:
[eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.
UniProtKB/Swiss-Prot Function:
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

Enzyme Numbers (IUBMB) for DHPS Gene

genes like me logo Genes that share phenotypes with DHPS: view

Animal Model Products

miRNA for DHPS Gene

miRTarBase miRNAs that target DHPS

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHPS Gene

Localization for DHPS Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHPS Gene COMPARTMENTS Subcellular localization image for DHPS gene
Compartment Confidence
cytosol 5
cytoskeleton 3
nucleus 3
plasma membrane 2
golgi apparatus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DHPS Gene

Pathways & Interactions for DHPS Gene

genes like me logo Genes that share pathways with DHPS: view

UniProtKB/Swiss-Prot P49366-DHYS_HUMAN

  • Pathway: Protein modification; eIF5A hypusination.

Gene Ontology (GO) - Biological Process for DHPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008612 peptidyl-lysine modification to peptidyl-hypusine IEA,TAS --
GO:0042102 positive regulation of T cell proliferation IEA --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
GO:0050983 deoxyhypusine biosynthetic process from spermidine IEA --
genes like me logo Genes that share ontologies with DHPS: view

No data available for SIGNOR curated interactions for DHPS Gene

Drugs & Compounds for DHPS Gene

(19) Drugs for DHPS Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
spermidine Experimental Pharma Antagonist, Pore Blocker 0
1-Guanidinium-7-Aminoheptane Experimental Pharma Target, inhibitor 0
NAD Pharma Full agonist, Agonist 0

(19) Additional Compounds for DHPS Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1,3-diaminopropane
  • 1,3-Diamino-N-propane
  • 1,3-Propanediamine
  • 1,3-Propylenediamine
  • 1,3-Trimethylenediamine
  • 3-Aminopropylamine
109-76-2
deoxyhypusine
  • N(6)-(4-Aminobutyl)-L-lysine
  • N(6)-(4-Aminobutyl)lysine
82543-85-9
genes like me logo Genes that share compounds with DHPS: view

Transcripts for DHPS Gene

Unigene Clusters for DHPS Gene

Deoxyhypusine synthase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHPS Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^
SP1: - - - - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - -
SP6: - -
SP7: - - - - - -
SP8: - - - - - -
SP9: - - - - -
SP10: -
SP11: - -
SP12:
SP13: - - - - - - -
SP14: - - - -
SP15: - - - - - -
SP16: -

ExUns: 11 ^ 12
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for DHPS Gene

GeneLoc Exon Structure for
DHPS
ECgene alternative splicing isoforms for
DHPS

Expression for DHPS Gene

mRNA expression in normal human tissues for DHPS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DHPS Gene

This gene is overexpressed in Lung (16.2), Retina (6.8), Tonsil (6.7), and Testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHPS Gene



SOURCE GeneReport for Unigene cluster for DHPS Gene Hs.79064

genes like me logo Genes that share expression patterns with DHPS: view

Protein tissue co-expression partners for DHPS Gene

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DHPS Gene

Orthologs for DHPS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHPS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DHPS 35
  • 88.62 (n)
  • 93.77 (a)
DHPS 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DHPS 35
  • 89.43 (n)
  • 94.58 (a)
DHPS 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dhps 35
  • 87.08 (n)
  • 91.33 (a)
Dhps 16
Dhps 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DHPS 35
  • 99.46 (n)
  • 99.19 (a)
DHPS 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dhps 35
  • 87.26 (n)
  • 92.14 (a)
oppossum
(Monodelphis domestica)
Mammalia DHPS 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DHPS 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHPS 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhps 35
  • 69.79 (n)
  • 76.02 (a)
MGC76269 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.11626 35
zebrafish
(Danio rerio)
Actinopterygii dhps 35
  • 72.53 (n)
  • 77.65 (a)
wufb52g04 35
dhps 36
  • 76 (a)
OneToMany
DHPS (2 of 2) 36
  • 82 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9614 35
fruit fly
(Drosophila melanogaster)
Insecta CG8005 37
  • 64 (a)
CG8005 35
  • 65.14 (n)
  • 64.18 (a)
CG8005 36
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006531 35
  • 62.94 (n)
  • 65.36 (a)
worm
(Caenorhabditis elegans)
Secernentea Y17G7B.4 37
  • 58 (a)
dhps-1 35
  • 56.63 (n)
  • 59.94 (a)
dhps-1 36
  • 57 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL036W 35
  • 60.69 (n)
  • 60.29 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E12695g 35
  • 57.63 (n)
  • 60.93 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DYS1 35
  • 59.31 (n)
  • 62.06 (a)
DYS1 36
  • 53 (a)
OneToOne
DYS1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons DHS 35
  • 59.56 (n)
  • 62.78 (a)
soybean
(Glycine max)
eudicotyledons Gma.5453 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6077 35
rice
(Oryza sativa)
Liliopsida Os.33154 35
Os03g0740600 35
  • 61.33 (n)
  • 62.92 (a)
corn
(Zea mays)
Liliopsida Zm.12010 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12482 35
bread mold
(Neurospora crassa)
Ascomycetes NCU05418 35
  • 61.49 (n)
  • 62.99 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1271.04c 35
  • 59.04 (n)
  • 63.86 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7280 36
  • 64 (a)
OneToOne
Species with no ortholog for DHPS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHPS Gene

ENSEMBL:
Gene Tree for DHPS (if available)
TreeFam:
Gene Tree for DHPS (if available)

Paralogs for DHPS Gene

No data available for Paralogs for DHPS Gene

Variants for DHPS Gene

Sequence variations from dbSNP and Humsavar for DHPS Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10425108 - 12,679,692(+) TAATT(C/G)TCATT nc-transcript-variant, reference, missense, utr-variant-5-prime
rs1050609 -- 12,680,279(-) GCACG(C/G/T)GGACC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs1050610 -- 12,680,257(-) CGCCG(C/G)CCACT nc-transcript-variant, reference, synonymous-codon, utr-variant-5-prime
rs1050612 -- 12,680,245(-) ACCAG(C/T)TGCAC nc-transcript-variant, reference, synonymous-codon, utr-variant-5-prime
rs1050613 -- 12,680,233(-) ATTTT(C/T)CTGGG nc-transcript-variant, reference, synonymous-codon, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for DHPS Gene

Variant ID Type Subtype PubMed ID
dgv3733n71 CNV Loss 21882294

Variation tolerance for DHPS Gene

Residual Variation Intolerance Score: 18.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.78; 58.15% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DHPS Gene

Disorders for DHPS Gene

MalaCards: The human disease database

(4) MalaCards diseases for DHPS Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pneumocystosis
  • pneumocystis carinii pneumonia
malaria
  • malaria, severe
meningococcal meningitis
neisseria meningitidis infection
  • meningococcal disease
- elite association - COSMIC cancer census association via MalaCards
Search DHPS in MalaCards View complete list of genes associated with diseases

Relevant External Links for DHPS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHPS
genes like me logo Genes that share disorders with DHPS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DHPS Gene

Publications for DHPS Gene

  1. Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins. (PMID: 7673224) Joe Y.A. … Park M.H. (J. Biol. Chem. 1995) 2 3 4 23 67
  2. Reversal of the deoxyhypusine synthesis reaction. Generation of spermidine or homospermidine from deoxyhypusine by deoxyhypusine synthase. (PMID: 12788913) Park J.H. … Park M.H. (J. Biol. Chem. 2003) 3 23 26
  3. dhfr and dhps genotype and sulfadoxine-pyrimethamine treatment failure in children with falciparum malaria in the Democratic Republic of Congo. (PMID: 19055622) Alker A.P. … Meshnick S.R. (Trop. Med. Int. Health 2008) 3 23
  4. Posttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modification. (PMID: 17476569) Wolff E.C. … Park M.H. (Amino Acids 2007) 3 23
  5. The post-translational synthesis of a polyamine-derived amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A). (PMID: 16452303) Park M.H. (J. Biochem. 2006) 3 23

Products for DHPS Gene

Sources for DHPS Gene

Content