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Aliases for DHPS Gene

Aliases for DHPS Gene

  • Deoxyhypusine Synthase 2 3
  • Migration-Inducing Gene 13 2 3
  • EC 2.5.1.46 4 63
  • DHS 3 4
  • DS 3 4
  • EC 2.5.1 63
  • MIG13 3

External Ids for DHPS Gene

Previous GeneCards Identifiers for DHPS Gene

  • GC19M012917
  • GC19M013009
  • GC19M012631
  • GC19M012647
  • GC19M012786
  • GC19M012359

Summaries for DHPS Gene

Entrez Gene Summary for DHPS Gene

  • This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for DHPS Gene

DHPS (Deoxyhypusine Synthase) is a Protein Coding gene. Diseases associated with DHPS include whipple disease and pneumocystosis. Among its related pathways are PTM- gamma carboxylation, hypusine formation and arylsulfatase activation and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include deoxyhypusine synthase activity.

UniProtKB/Swiss-Prot for DHPS Gene

  • Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue

Gene Wiki entry for DHPS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHPS Gene

Genomics for DHPS Gene

Regulatory Elements for DHPS Gene

Genomic Location for DHPS Gene

Start:
12,675,717 bp from pter
End:
12,681,902 bp from pter
Size:
6,186 bases
Orientation:
Minus strand

Genomic View for DHPS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHPS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHPS Gene

Proteins for DHPS Gene

  • Protein details for DHPS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49366-DHYS_HUMAN
    Recommended name:
    Deoxyhypusine synthase
    Protein Accession:
    P49366
    Secondary Accessions:
    • A8K688
    • M0R1I5
    • Q13184
    • Q13276
    • Q9UDG0

    Protein attributes for DHPS Gene

    Size:
    369 amino acids
    Molecular mass:
    40971 Da
    Cofactor:
    Name=NAD(+); Xref=ChEBI:CHEBI:57540;
    Quaternary structure:
    • Homotetramer formed by a dimer of dimers.
    SequenceCaution:
    • Sequence=AL520040; Type=Frameshift; Positions=329, 344, 355; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DHPS Gene

    Alternative splice isoforms for DHPS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHPS Gene

Proteomics data for DHPS Gene at MOPED

Post-translational modifications for DHPS Gene

  • Ubiquitination at Lys19, Lys73, Lys212, Lys329, and Lys366
  • Modification sites at PhosphoSitePlus

Domains for DHPS Gene

Protein Domains for DHPS Gene

Suggested Antigen Peptide Sequences for DHPS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49366

UniProtKB/Swiss-Prot:

DHYS_HUMAN :
  • P49366
Family:
  • Belongs to the deoxyhypusine synthase family.
genes like me logo Genes that share domains with DHPS: view

No data available for Gene Families for DHPS Gene

Function for DHPS Gene

Molecular function for DHPS Gene

GENATLAS Biochemistry: deoxyhypusine synthase,required for the post-translational formation of hypusine by modification of a specific residue in eucaryotic initiation factor 5A (EI5FA),pivotal in cell proliferation
UniProtKB/Swiss-Prot CatalyticActivity: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
UniProtKB/Swiss-Prot Function: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue

Enzyme Numbers (IUBMB) for DHPS Gene

Gene Ontology (GO) - Molecular Function for DHPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14622290
GO:0034038 deoxyhypusine synthase activity TAS --
genes like me logo Genes that share ontologies with DHPS: view

miRNA for DHPS Gene

miRTarBase miRNAs that target DHPS

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DHPS Gene

Localization for DHPS Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHPS Gene COMPARTMENTS Subcellular localization image for DHPS gene
Compartment Confidence
cytosol 4
cytoskeleton 3
nucleus 2
plasma membrane 2
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DHPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DHPS: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DHPS Gene

Pathways for DHPS Gene

genes like me logo Genes that share pathways with DHPS: view

UniProtKB/Swiss-Prot P49366-DHYS_HUMAN

  • Pathway: Protein modification; eIF5A hypusination

Gene Ontology (GO) - Biological Process for DHPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS 7673224
GO:0008284 positive regulation of cell proliferation TAS 8549832
GO:0008612 peptidyl-lysine modification to peptidyl-hypusine TAS --
GO:0042102 positive regulation of T cell proliferation IEA --
GO:0042593 glucose homeostasis IEA --
genes like me logo Genes that share ontologies with DHPS: view

Compounds for DHPS Gene

(7) HMDB Compounds for DHPS Gene

Compound Synonyms Cas Number PubMed IDs
1,3-Diaminopropane
  • 1,3-Diamino-n-propane
109-76-2
1-pyrroline
  • Pyr1
5724-81-2
Dehydrospermidine
  • N,C-di(3-aminopropyl)-imine
Not Available
Deoxyhypusine
  • N(6)-(4-Aminobutyl)lysine
82543-85-9
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9

(2) Drugbank Compounds for DHPS Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
1-Guanidinium-7-Aminoheptane
target inhibitor
Nicotinamide-Adenine-Dinucleotide
53-84-9 target

(36) Novoseek inferred chemical compound relationships for DHPS Gene

Compound -log(P) Hits PubMed IDs
dihydropteroate 98.7 105
deoxyhypusine 98.5 159
hypusine 97.5 37
sulfadoxine 95.1 37
sulfadoxine/pyrimethamine 93.1 53
genes like me logo Genes that share compounds with DHPS: view

Transcripts for DHPS Gene

Unigene Clusters for DHPS Gene

Deoxyhypusine synthase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHPS Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^
SP1: - - - - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - -
SP6: - -
SP7: - - - - - -
SP8: - - - - - -
SP9: - - - - -
SP10: -
SP11: - -
SP12:
SP13: - - - - - - -
SP14: - - - -
SP15: - - - - - -
SP16: -

ExUns: 11 ^ 12
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for DHPS Gene

GeneLoc Exon Structure for
DHPS
ECgene alternative splicing isoforms for
DHPS

Expression for DHPS Gene

mRNA expression in normal human tissues for DHPS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHPS Gene

SOURCE GeneReport for Unigene cluster for DHPS Gene Hs.79064

genes like me logo Genes that share expressions with DHPS: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DHPS Gene

Orthologs for DHPS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHPS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHPS 35
  • 99.46 (n)
  • 99.19 (a)
DHPS 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DHPS 35
  • 88.62 (n)
  • 93.77 (a)
DHPS 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DHPS 35
  • 89.43 (n)
  • 94.58 (a)
DHPS 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dhps 35
  • 87.08 (n)
  • 91.33 (a)
Dhps 16
Dhps 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DHPS 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DHPS 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dhps 35
  • 87.26 (n)
  • 92.14 (a)
lizard
(Anolis carolinensis)
Reptilia DHPS 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11626 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dhps 35
  • 69.79 (n)
  • 76.02 (a)
MGC76269 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9614 35
zebrafish
(Danio rerio)
Actinopterygii dhps 35
  • 72.53 (n)
  • 77.65 (a)
dhps 36
  • 76 (a)
OneToMany
DHPS (2 of 2) 36
  • 82 (a)
OneToMany
wufb52g04 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006531 35
  • 62.94 (n)
  • 65.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8005 35
  • 65.14 (n)
  • 64.18 (a)
CG8005 36
  • 61 (a)
OneToOne
CG8005 37
  • 64 (a)
worm
(Caenorhabditis elegans)
Secernentea dhps-1 35
  • 56.63 (n)
  • 59.94 (a)
dhps-1 36
  • 57 (a)
OneToOne
Y17G7B.4 37
  • 58 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL036W 35
  • 60.69 (n)
  • 60.29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DYS1 35
  • 59.31 (n)
  • 62.06 (a)
DYS1 36
  • 53 (a)
OneToOne
DYS1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E12695g 35
  • 57.63 (n)
  • 60.93 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6077 35
soybean
(Glycine max)
eudicotyledons Gma.5453 35
thale cress
(Arabidopsis thaliana)
eudicotyledons DHS 35
  • 59.56 (n)
  • 62.78 (a)
corn
(Zea mays)
Liliopsida Zm.12010 35
rice
(Oryza sativa)
Liliopsida Os.33154 35
Os03g0740600 35
  • 61.33 (n)
  • 62.92 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05418 35
  • 61.49 (n)
  • 62.99 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1271.04c 35
  • 59.04 (n)
  • 63.86 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12482 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7280 36
  • 64 (a)
OneToOne
Species with no ortholog for DHPS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHPS Gene

ENSEMBL:
Gene Tree for DHPS (if available)
TreeFam:
Gene Tree for DHPS (if available)

Paralogs for DHPS Gene

No data available for Paralogs for DHPS Gene

Variants for DHPS Gene

Sequence variations from dbSNP and Humsavar for DHPS Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs9517 -- 12,679,634(-) TGGAG(C/G)AGAAC reference, missense, nc-transcript-variant
rs1050609 -- 12,680,279(-) GCACG(C/G)GGACC reference, missense, nc-transcript-variant
rs1050610 -- 12,680,257(-) CGCCG(C/G)CCACT reference, synonymous-codon, nc-transcript-variant
rs1050612 -- 12,680,245(-) ACCAG(C/T)TGCAC reference, synonymous-codon, nc-transcript-variant
rs1050613 -- 12,680,233(-) ATTTT(C/T)CTGGG reference, synonymous-codon, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for DHPS Gene

Variant ID Type Subtype PubMed ID
dgv3733n71 CNV Loss 21882294

Relevant External Links for DHPS Gene

HapMap Linkage Disequilibrium report
DHPS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHPS Gene

Disorders for DHPS Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for DHPS Gene including...

Search for DHPS Gene in MalaCards »

(3) University of Copenhagen DISEASES for DHPS Gene

(12) Novoseek inferred disease relationships for DHPS Gene

Disease -log(P) Hits PubMed IDs
malaria falciparum 82.3 7
malaria 78.3 21
pneumonia pneumocystis carinii 75.8 10
pneumonia 52.5 15
parasitemia 45.2 2
genes like me logo Genes that share disorders with DHPS: view

No data available for UniProtKB/Swiss-Prot for DHPS Gene

Publications for DHPS Gene

  1. Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins. (PMID: 7673224) Joe Y.A. … Park M.H. (J. Biol. Chem. 1995) 2 3 4 23
  2. Molecular characterization of a cDNA encoding functional human deoxyhypusine synthase and chromosomal mapping of the corresponding gene locus. (PMID: 8549832) Bevec D. … Steinkasserer A. (FEBS Lett. 1996) 3 4 23
  3. Purification and characterization of human deoxyhypusine synthase from HeLa cells. (PMID: 7750572) Klier H. … Eder J. (FEBS Lett. 1995) 3 4 23
  4. Molecular cloning and functional expression of human deoxyhypusine synthase cDNA based on expressed sequence tag information. (PMID: 8615810) Yan Y.P. … Chen K.Y. (Biochem. J. 1996) 3 4 23
  5. Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site. (PMID: 9493264) Liao D.-I. … Davies D.R. (Structure 1998) 3 4 23

Products for DHPS Gene

Sources for DHPS Gene

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