DHODH Gene
protein-coding GIFtS: 60
GCID: GC16P072042
|
|
dihydroorotate dehydrogenase (quinone)(Previous name: dihydroorotate dehydrogenase )
| |
Aliases
for DHODH gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dihydroorotate Dehydrogenase (Quinone)1 2 | | Dihydroorotate Dehydrogenase1 | | Dihydroorotate Oxidase2 3 | | Dihydroorotate Dehydrogenase (Quinone), Mitochondrial2 | | DHOdehase2 3 | | Human Complement Of Yeast URA12 | | POADS2 5 | | EC 1.3.5.23 | | URA12 5 | | EC 1.3.3.18 |
Export aliases for DHODH gene to outside databasesPrevious GC identifers: GC16P062936 GC16P072765 GC16P071778 GC16P071818 GC16P070600 GC16P057809 |
Summaries
for DHODH gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DHODH:
The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation ofdihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on theouter surface of the inner mitochondrial membrane. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: PYRD_HUMAN, Q02127Function: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor
|
Genomic Views
for DHODH gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DHODH gene promoter:
AhR AML1a p300 CUTL1 NF-kappaB POU3F2 Evi-1 Arnt GATA-2 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DHODH
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHODH |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q22 Ensembl cytogenetic band: 16q22.2 HGNC cytogenetic band: 16q22.2DHODH Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P072042: view genomic region
(about GC identifiers)
Start:
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72,042,487 bp from pter |
End:
|
72,058,955 bp from pter |
Size:
|
16,469 bases |
Orientation:
|
plus strand |
|
Proteins
for DHODH gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PYRD_HUMAN, Q02127 (See
protein sequence)Recommended Name: Dihydroorotate dehydrogenase (quinone), mitochondrial precursor Size: 395 amino acids; 42867 Da
Cofactor: Binds 1 FMN per subunit
Subunit: Monomer
Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein
Miscellaneous: The identification of DHODH defects as the cause of postaxial acrofacial dysostosis (POADS) was obtainedvia exome sequencing (PubMed:19915526), demonstrating that this method is a powerful tool for identifying genesunderlying rare Mendelian disorders. Exome sequencing consists of targeted resequencing of all protein-codingsubsequences, which requires around 5% as much sequencing as a whole human genome
6/24 PDB 3D structures from  and Proteopedia  for DHODH (see all 24):1D3G (3D)
1D3H (3D)
2B0M (3D)
2BXV (3D)
2FPT (3D)
2FPV (3D)
Secondary accessions: A8K8C8 Q6P176Explore the universe of human proteins at neXtProt for DHODH: NX_Q02127
Post-translational modifications:
The uncleaved transit peptide is required for mitochondrial targeting and proper membrane integration1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q02127
4/12 DME Specific Peptides for DHODH (Q02127) (see all 12)
DHODH Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001352.2
ENSEMBL proteins: ENSP00000461848 ENSP00000460966 ENSP00000464249 ENSP00000464333 ENSP00000219240 Reactome Protein details: Q02127
Human Recombinant Protein Products for DHODH:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
DHODH for ontologies About GeneDecksing
DHODH Antibody Products:
Assay Products for DHODH: |
Protein
Domains /
Families
for DHODH gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DHODH for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q02127ProtoNet protein and cluster: Q02127 1 Blocks protein family: IPB001295 Dihydroorotate dehydrogenase
UniProtKB/Swiss-Prot: PYRD_HUMAN, Q02127Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily |
Function
for DHODH gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: PYRD_HUMAN, Q02127Function: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptorCatalytic activity: (S)-dihydroorotate + a quinone = orotate + a quinol Genatlas biochemistry entry for DHODH:dihydroorotate dehydrogenase,catalyzing the fourth step of the pyrimidine de novo biosynthesis
Enzyme Numbers (IUBMB): EC 1.3.3.12 EC 1.3.5.21
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
DHODH for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for DHODH:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DHODH (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DHODH (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DHODH (NM_001361) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DHODH | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHODH |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHODH |
|
Pathways & Interactions
for DHODH gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Metabolism | | | 2 | Pyrimidine metabolism | | | 3 | Pyrimidine biosynthesis | | | 4 | Purine metabolism | | | 5 | Purine metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for DHODH
2 
Kegg Pathways (Kegg details for DHODH):
UniProtKB/Swiss-Prot: PYRD_HUMAN, Q02127Pathway: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route):step 1/1
DHODH for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DHODH
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/8 Interacting proteins for DHODH (Q021273 ENSP000002192404) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
About this table
Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006206 | pyrimidine nucleobase metabolic process |
TAS | -- | | GO:0006207 | 'de novo' pyrimidine nucleobase biosynthetic process |
NAS | -- | | GO:0006222 | UMP biosynthetic process |
-- | -- | | GO:0007565 | female pregnancy |
IEA | -- | | GO:0007595 | lactation |
IEA | -- |
DHODH for ontologies About GeneDecksing
|
Drugs & Compounds
for DHODH gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DHODH for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for DHODH |
 Browse Tocris compounds for DHODH
7 HMDB Compounds for DHODH About this table
10/24 DrugBank Compounds for DHODH (see all 24) About this table
10/36 Novoseek chemical compound relationships for DHODH gene (see all 36) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| dihydroorotate |
99.3 |
280 |
8852433 (7), 8925840 (6), 9179295 (6), 9802339 (5) (see all 99) |
| brequinar sodium |
96.1 |
32 |
2386542 (3), 8687451 (3), 11329288 (3), 9802339 (2) (see all 14) |
| dichloroallyllawsone |
95.8 |
6 |
12213251 (2), 12189151 (1), 7741767 (1) |
| redoxal |
95.1 |
9 |
10664450 (2), 12213251 (2), 11248707 (1), 12189151 (1) (see all 5) |
| leflunomide |
91.3 |
47 |
16120318 (3), 18031184 (2), 10600330 (2), 7575649 (2) (see all 25) |
| quinoline-4-carboxylic acid |
90.7 |
1 |
9802339 (1) |
| pyrimidine |
88.8 |
52 |
18312275 (2), 7473131 (1), 9815796 (1), 9504336 (1) (see all 35) |
| orotic acid |
88.5 |
21 |
10889450 (2), 11329288 (2), 17123468 (1), 2306795 (1) (see all 14) |
| isoxazol |
88 |
1 |
9802339 (1) |
| decylubiquinone |
83.1 |
1 |
9802339 (1) |
1 PharmGKB related drug/compound annotation for DHODH gene About this tableSearch CenterWatch for drugs/clinical trials and news about DHODH / PYRD
|
Transcripts
for DHODH gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DHODH gene (2 alternative transcripts): NM_001361.4 NM_001025193.1 Unigene Cluster for DHODH: Dihydroorotate dehydrogenase (quinone) Hs.654427 [show with all ESTs]Unigene Representative Sequence: NM_0013619 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000572887 ENST00000574309 ENST00000571288 ENST00000576145 ENST00000573922
ENST00000572003 ENST00000573843 ENST00000571392 ENST00000219240(uc002fbp.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DHODH (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DHODH (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DHODH (NM_001361) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DHODH | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHODH |
Additional cDNA sequence: AK292293.1 BC065245.1 M94065.1 15 DOTS entries: DT.105579 DT.97821776 DT.120676292 DT.95264901 DT.97841858 DT.100032231 DT.106531 DT.120676132 DT.40215694 DT.95264900 DT.100023695 DT.120676089 DT.437840 DT.97841859 DT.120676282 24/82 AceView cDNA sequences (see all 82): CR593960 BU069561 BG024665 NM_001361 AA402362 AA412074 BQ689300 BU859158 BC065245 CB121224 BQ880089 AI318268 BE902847 BM673367 BM472821 BM854073 BU176732 BM834479 CA314529 BP362226 AU130529 AI499306 BQ216447 AK097300
GeneLoc Exon Structure
|
Expression
for DHODH gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DHODH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See DHODH Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DHODH
SOURCE GeneReport for Unigene cluster: Hs.654427
SABiosciences Custom PCR Arrays for DHODH
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DHODH
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DHODH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DHODH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHODH | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHODH |
Orthologs
for DHODH gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for DHODH gene from 11/36 species (see all 36) About this table
ENSEMBL Gene Tree for DHODH (if available)
TreeFam Gene Tree for DHODH (if available) |
Paralogs
for DHODH gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DHODH gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DHODH (72042487 - 72058955 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DHODH
1 CNV: 4011
Human Gene Mutation Database (HGMD): DHODH
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DHODH |
|
Disorders
/ Diseases
for DHODH gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DHODH for disorders About GeneDecksing
OMIM gene information: 126064
OMIM disorders: 264750
UniProtKB/Swiss-Prot: PYRD_HUMAN, Q02127
Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:263750]; also known as Millersyndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of theposterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder:only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, havebeen described among a total of around 30 reported cases
20  diseases for DHODH: About MalaCardspostaxial acrofacial dysostosis acrofacial dysostosis supernumerary nipples treacher collins syndrome
dysostosis rheumatoid arthritis conduct disorder squamous cell carcinoma
coloboma adhd myeloid leukemia arthritis
pneumonia malaria leukemia hypoxia
tuberculosis melanoma carcinoma mycobacterium tuberculosis
8 Novoseek disease relationships for DHODH gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| rheumatoid arthritis |
49 |
6 |
16480261 (1), 18031184 (1), 8925840 (1), 19605743 (1) (see all 5) |
| malaria |
33.6 |
8 |
17228860 (2), 15727850 (2), 17330044 (1), 18522386 (1) |
| autoimmune diseases |
32.7 |
3 |
10673429 (1), 18672895 (1) |
| chagas disease |
16 |
1 |
16172019 (1) |
| virus infection |
0 |
2 |
8925840 (1), 9179295 (1) |
| inflammation |
0 |
1 |
12003373 (1) |
| tumors |
0 |
3 |
2306706 (1), 8687451 (1), 7741767 (1) |
| cancer |
0 |
3 |
10673429 (1), 8687451 (1) |
Human Genome Epidemiology (HuGE) Navigator: DHODH (3 documents)
Export disorders for DHODH gene to outside databases
|
Publications
for DHODH gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DHODH gene, integrated from 9 sources (see all 151):
(articles sorted by number of sources associating them with DHODH) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Requirements for the mitochondrial import and localization of dihydroorotate dehydrogenase. (PubMed id 10727948)1, 2, 9 Rawls J....Loffler M. (2000)
- Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents. (PubMed id 10673429)1, 2, 9 Liu S.... Clardy J. (2000)
- Functional expression of a fragment of human dihydroorotate dehydrogenase by means of the baculovirus expression vector system, and kinetic investigation of the purified recombinant enzyme. (PubMed id 8925840)1, 2, 9 Knecht W.... Loffler M. (1996)
- Regional mapping of the gene encoding dihydroorotate dehydrogenase, an enzyme involved in UMP synthesis, electron transport, and superoxide generation, to human chromosome region 16q22. (PubMed id 8211381)1, 3, 9 Barnes T....Patterson D. (1993)
- Cloning and sequencing of a human cDNA coding for dihydroorotate dehydrogenase by complementation of the corresponding yeast mutant. (PubMed id 1446837)1, 2, 9 Minet M.... Lacroute F. (1992)
- Recombinant human dihydroorotate dehydrogenase: expression, purification, and characterization of a catalytically functional truncated enzyme. (PubMed id 7487077)1, 2, 9 Copeland R.A....Patterson T.A. (1995)
- Exome sequencing identifies the cause of a mendelian disorder. (PubMed id 19915526)1, 2, 9 Ng S.B....Bamshad M.J. (2010)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Dihydroorotate dehydrogenase is required for N-(4-hyd roxyphenyl)retinamide-induced reactive oxygen species production and apoptosis. (PubMed id 20399851)1, 9 Hail N....Shearn C. (2010)
|
External Searches for DHODH gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DHODH gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DHODH gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DHODH gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DHODH | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DHODH gene:
Search GeneIP for patents involving DHODH
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DHODH gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DHODH | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DHODH | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DHODH | | | OriGene Protein Over-expression Lysate for DHODH | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DHODH | | OriGene 3'-UTR Clone for DHODH | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DHODH | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DHODH | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DHODH | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DHODH | | OriGene Custom Protein Services for DHODH | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DHODH | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DHODH | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHODH | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DHODH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHODH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DHODH |
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| | | | Search Tocris compounds for DHODH |
| |  |  |  |  | | | | | | Recombinant Protein for DHODH |
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 | | | DHODH Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHODH |
|  |  |  |  | | | | Search ThermoFisher Antibodies for DHODH |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHODH |
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