DHFRP1 Gene
pseudogene GIFtS: 24
GCID: GC18M023747
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dihydrofolate reductase pseudogene 1
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Aliases
for DHFRP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
|---|
| Dihydrofolate Reductase Pseudogene 11 2 | | DHFR5 |
Export aliases for DHFRP1 gene to outside databasesPrevious GC identifers: GC18U990010 GC02P082937 GC18M022002 |
Summaries
for DHFRP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
 summary
for DHFRP1: Dihydrofolate reductase (DHFR) is a member of the reductase family of enzymes that is ubiquitously expressed
in all organisms. It catalyzes tetrahydrofolate regeneration by reduction of dihydrofolate, using NADPH as a
cofactor. Tetrahydrofolate is essential for de novo purine and thymidylate synthesis, hence DHFR has a
critical role in cell growth and proliferation. DHFR is the target for many anticancer and antibiotic
therapies including methotrexate and trimethoprim. Basal and regulated DHFR gene expression is controlled by
Sp1 and E2F family transcription factors respectively and levels of this enzyme peak at the G1/S cell cycle
boundary. Autoregulation, through DHFR-RNA interactions, has also been reported. The human gene encoding
this enzyme is localized to 5q11.2-13.2.
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Genomic Views
for DHFRP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for DHFRP1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DHFRP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHFRP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q11.2 Ensembl cytogenetic band: 18q11.2 HGNC cytogenetic band: 18q11.2DHFRP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18M023747: view genomic region
(about GC identifiers)
Start:
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23,747,826 bp from pter |
End:
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23,751,321 bp from pter |
Size:
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3,496 bases |
Orientation:
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minus strand |
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Proteins
for DHFRP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB: --
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Protein
Domains /
Families
for DHFRP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function
for DHFRP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Molecular Function:
Genatlas biochemistry entry for DHFRP1:dihydrofolate reductase,pseudogene 1
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
DHFRP1 for ontologies About GeneDecksing
Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for DHFRP1 | |  | Search LifeMap BioReagents cell lines for DHFRP1 | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHFRP1 |
Pathways & Interactions
for DHFRP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table 
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | E2F transcription factor network | |
1  BioSystems Pathway for DHFRP1
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DHFRP1
Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000082 | G1/S transition of mitotic cell cycle |
TAS | -- | | GO:0000083 | regulation of transcription involved in G1/S phase of mitotic cell cycle |
TAS | -- | | GO:0000278 | mitotic cell cycle |
TAS | -- | | GO:0006545 | glycine biosynthetic process |
NAS | -- | | GO:0006730 | one-carbon metabolic process |
IEA | -- |
DHFRP1 for ontologies About GeneDecksing
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Drugs & Compounds
for DHFRP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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Compounds for DHFRP1 available from Tocris Bioscience About this table
Search CenterWatch for drugs/clinical trials and news about DHFRP1
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Transcripts
for DHFRP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000579682 ENST00000307796
GeneLoc Exon Structure
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Expression
for DHFRP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DHFRP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image SABiosciences Custom PCR Arrays for DHFRP1
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat DHFRP1 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DHFRP1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHFRP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHFRP1 |
Orthologs
for DHFRP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
ENSEMBL Gene Tree for DHFRP1 (if available)
TreeFam Gene Tree for DHFRP1 (if available) |
Paralogs
for DHFRP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DHFRP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for DHFRP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DHFRP1 for disorders About GeneDecksing
OMIM gene information: 126060
OMIM disorders: --
2  diseases for DHFRP1: About MalaCardsanemia, megaloblastic, due to dhfr deficiency anemia
Export disorders for DHFRP1 gene to outside databases
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Publications
for DHFRP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DHFRP1 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with DHFRP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A human dihydrofolate reductase pseudogene and its relationship to the multiple forms of specific messenger RNA. (PubMed id 6306253)1, 3 Masters J.N.... Attardi G. (1983)
- An artifact derived from a pseudogene led to the disco very of microRNA binding site polymorphism in the 3'-untranslated region of the human dihydrofolate reductase gene. (PubMed id 22201119)1 Hayashi H....Itoh K. (2012)
- Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3- d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents. (PubMed id 19719239)1 Gangjee A....Makin J. (2009)
- Multiple conformers in active site of human dihydrofolate reductase F31R/Q35E double mutant suggest structural basis for methotrexate resistance. (PubMed id 19478082)1 Volpato J.P.... Pelletier J.N. (2009)
- Correlations of inhibitor kinetics for Pneumocystis jirovecii and human dihydrofolate reductase with structural data for human active site mutant enzyme complexes. (PubMed id 19196009)1 Cody V.... Rosowsky A. (2009)
- Novel boron-containing, nonclassical antifolates: synthesis and preliminary biological and structural evaluation. (PubMed id 17569517)1 Reynolds R.C.... Borhani D.W. (2007)
- Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH. (PubMed id 15681865)1 Cody V....Pangborn W. (2005)
- Solution structure of human dihydrofolate reductase in its complex with trimethoprim and NADPH. (PubMed id 16222560)1 Kovalevskaya N.V.... Feeney J. (2005)
- Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry. (PubMed id 15039552)1 Cody V.... Queener S.F. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S....Malek J. (2004)
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External Searches for DHFRP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing DHFRP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing DHFRP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DHFRP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DHFRP1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for DHFRP1 gene:
Search GeneIP for patents involving DHFRP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for DHFRP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DHFRP1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DHFRP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHFRP1 | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DHFRP1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHFRP1 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DHFRP1 |
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 | | | DHFRP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHFRP1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for DHFRP1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DHFRP1 |
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