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Aliases for DHFRP1 Gene

Aliases for DHFRP1 Gene

  • Dihydrofolate Reductase Pseudogene 1 2 3

External Ids for DHFRP1 Gene

Previous GeneCards Identifiers for DHFRP1 Gene

  • GC18U990010
  • GC02P082937
  • GC18M022002
  • GC18M023747

Summaries for DHFRP1 Gene

GeneCards Summary for DHFRP1 Gene

DHFRP1 (Dihydrofolate Reductase Pseudogene 1) is a Pseudogene. Among its related pathways are E2F transcription factor network. GO annotations related to this gene include mRNA binding and NADP binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHFRP1 Gene

Genomics for DHFRP1 Gene

Genomic Location for DHFRP1 Gene

Chromosome:
18
Start:
26,167,862 bp from pter
End:
26,171,357 bp from pter
Size:
3,496 bases
Orientation:
Minus strand

Genomic View for DHFRP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for DHFRP1 Gene

No data available for Regulatory Elements for DHFRP1 Gene

Proteins for DHFRP1 Gene

Post-translational modifications for DHFRP1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for DHFRP1 Gene

Domains & Families for DHFRP1 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for DHFRP1 Gene

Function for DHFRP1 Gene

Molecular function for DHFRP1 Gene

GENATLAS Biochemistry:
dihydrofolate reductase,pseudogene 1

Gene Ontology (GO) - Molecular Function for DHFRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IDA 21876184
GO:0004146 dihydrofolate reductase activity NAS 6687716
GO:0005542 folic acid binding IDA 2303423
GO:0008144 drug binding IDA 12096917
GO:0051870 methotrexate binding IDA 2303423
genes like me logo Genes that share ontologies with DHFRP1: view

Phenotypes for DHFRP1 Gene

GenomeRNAi human phenotypes for DHFRP1:
genes like me logo Genes that share phenotypes with DHFRP1: view

miRNA for DHFRP1 Gene

miRTarBase miRNAs that target DHFRP1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for DHFRP1 Gene

Localization for DHFRP1 Gene

Gene Ontology (GO) - Cellular Components for DHFRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DHFRP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for DHFRP1 Gene

Pathways & Interactions for DHFRP1 Gene

genes like me logo Genes that share pathways with DHFRP1: view

Pathways by source for DHFRP1 Gene

1 BioSystems pathway for DHFRP1 Gene

Interacting Proteins for DHFRP1 Gene

Gene Ontology (GO) - Biological Process for DHFRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006545 glycine biosynthetic process IEA --
GO:0006729 tetrahydrobiopterin biosynthetic process ISS --
genes like me logo Genes that share ontologies with DHFRP1: view

No data available for SIGNOR curated interactions for DHFRP1 Gene

Drugs & Compounds for DHFRP1 Gene

(2) Drugs for DHFRP1 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR 1387
Pralatrexate Approved Pharma Antifolate,a folate analog, RFC-1 targeted DHFR inhibitor 0
genes like me logo Genes that share compounds with DHFRP1: view

Transcripts for DHFRP1 Gene

mRNA/cDNA for DHFRP1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for DHFRP1 Gene

No ASD Table

Relevant External Links for DHFRP1 Gene

GeneLoc Exon Structure for
DHFRP1
ECgene alternative splicing isoforms for
DHFRP1

Expression for DHFRP1 Gene

mRNA expression in normal human tissues for DHFRP1 Gene

genes like me logo Genes that share expression patterns with DHFRP1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DHFRP1 Gene

Orthologs for DHFRP1 Gene

Evolution for DHFRP1 Gene

ENSEMBL:
Gene Tree for DHFRP1 (if available)
TreeFam:
Gene Tree for DHFRP1 (if available)

No data available for Orthologs for DHFRP1 Gene

Paralogs for DHFRP1 Gene

No data available for Paralogs for DHFRP1 Gene

Variants for DHFRP1 Gene

Relevant External Links for DHFRP1 Gene

HapMap Linkage Disequilibrium report
DHFRP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for DHFRP1 Gene

Disorders for DHFRP1 Gene

genes like me logo Genes that share disorders with DHFRP1: view

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for DHFRP1 Gene

Publications for DHFRP1 Gene

  1. Nucleotide sequence analysis of the HLA class I region spanning the 237-kb segment around the HLA-B and -C genes. (PMID: 9177776) Mizuki N. … Inoko H. (Genomics 1997) 23 67
  2. Identification of a base pair substitution at the tetranucleotide tandem repeat locus DHFRP2 (AAAC)n in a worldwide survey. (PMID: 8956994) PAcrez-Lezaun A. … Bertranpetit J. (Int. J. Legal Med. 1996) 23 67
  3. A human dihydrofolate reductase pseudogene and its relationship to the multiple forms of specific messenger RNA. (PMID: 6306253) Masters J.N. … Attardi G. (J. Mol. Biol. 1983) 2 67
  4. Human endothelial dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recycling. (PMID: 23707606) Whitsett J. … Vasquez-Vivar J. (Free Radic. Biol. Med. 2013) 67
  5. An artifact derived from a pseudogene led to the discovery of microRNA binding site polymorphism in the 3'-untranslated region of the human dihydrofolate reductase gene. (PMID: 22201119) Hayashi H. … Itoh K. (Drug Metab. Pharmacokinet. 2012) 67

Products for DHFRP1 Gene

Sources for DHFRP1 Gene

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