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DHFRL1 Gene

protein-coding   GIFtS: 51
GCID: GC03M093766

Dihydrofolate Reductase-Like 1

(Previous name: dihydrofolate reductase pseudogene 4)
(Previous symbol: DHFRP4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Dihydrofolate Reductase-Like 11 2
DHFRP41 2 3
Dihydrofolate Reductase Pseudogene 41 2
Dihydrofolate Reductase-Like Protein 12 3
EC 1.5.1.33 8
Dihydrofolate Reductase, Mitochondrial2

External Ids:    HGNC: 273091   Entrez Gene: 2008952   Ensembl: ENSG000001787007   UniProtKB: Q86XF03   
ORGUL members:         

Export aliases for DHFRL1 gene to outside databases

Previous GC identifers: GC03M095260 GC03M091139


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DHFRL1 Gene:
DHFRL1 (dihydrofolate reductase-like 1) is a protein-coding gene. Diseases associated with DHFRL1 include meningioma, and pneumonia. GO annotations related to this gene include dihydrofolate reductase activity and mRNA binding. An important paralog of this gene is DHFR.

UniProtKB/Swiss-Prot: DYRL1_HUMAN, Q86XF0
Function: Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis
pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the DHFRL1 gene promoter:
         Nkx3-1   AML1a   AP-1   Nkx3-1 v1   Nkx2-5   Evi-1   RORalpha1   S8   FOXO4   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDHFRL1 promoter sequence
   Search Chromatin IP Primers for DHFRL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DHFRL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q11.1   Ensembl cytogenetic band:  3q11.1   HGNC cytogenetic band: 3q11.2

DHFRL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHFRL1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M093766:  view genomic region     (about GC identifiers)

Start:
93,766,680 bp from pter      End:
93,782,233 bp from pter
Size:
15,554 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DYRL1_HUMAN, Q86XF0 (See protein sequence)
Recommended Name: Dihydrofolate reductase, mitochondrial  
Size: 187 amino acids; 21620 Da
Secondary accessions: D3DN30 Q6P4I9

Explore the universe of human proteins at neXtProt for DHFRL1: NX_Q86XF0

Explore proteomics data for DHFRL1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys56
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for DHFRL1 (Q86XF0)
     QNMGIGK  KQNLVIMG  VLSRELKEPPQGAHFL 


    See DHFRL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001182572.1  NP_789785.1  

    ENSEMBL proteins: 
     ENSP00000319170   ENSP00000377768   ENSP00000418415   ENSP00000420810  
    Reactome Protein details: Q86XF0

    DHFRL1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR024072 DHFR-like_dom
     IPR012259 DHFR
     IPR001796 DHFR_dom

    Graphical View of Domain Structure for InterPro Entry Q86XF0

    ProtoNet protein and cluster: Q86XF0

    1 Blocks protein domain: IPB001796 Dihydrofolate reductase

    UniProtKB/Swiss-Prot: DYRL1_HUMAN, Q86XF0
    Similarity: Belongs to the dihydrofolate reductase family
    Similarity: Contains 1 DHFR (dihydrofolate reductase) domain


    DHFRL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DYRL1_HUMAN, Q86XF0
    Function: Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis
    pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR
    Catalytic activity: 5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH
    Biophysicochemical properties: Kinetic parameters: KM=209 uM for dihydrofolate; KM=20 uM for NADPH;

         Enzyme Number (IUBMB): EC 1.5.1.31 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003729mRNA binding IDA--
    GO:0004146dihydrofolate reductase activity IMP--
    GO:0050661NADP binding IEA--
         
    DHFRL1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DHFRL1
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    miRNA
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    miRTarBase miRNAs that target DHFRL1:
    hsa-mir-215-5p (MIRT024349), hsa-mir-192-5p (MIRT026377)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DYRL1_HUMAN, Q86XF0: Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    extracellular1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane IMP--
    GO:0005759mitochondrial matrix IMP--

    DHFRL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DHFRL1 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1One carbon pool by folate
    One carbon pool by folate0.53
    dTMP de novo biosynthesis (mitochondrial)0.00
    Trans-sulfuration and one carbon metabolism0.43
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Defective BTD causes biotidinase deficiency
    Defective BTD causes biotidinase deficiency1.00
    Metabolism of vitamins and cofactors1.00
    Defective AMN causes hereditary megaloblastic anemia 11.00
    Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC1.00
    Defective MMAA causes methylmalonic aciduria type cblA1.00
    Defective MUT causes methylmalonic aciduria mut type1.00
    Defective CD320 causes methylmalonic aciduria1.00
    Defects in cobalamin (B12) metabolism1.00
    4Folate biosynthesis
    Folate biosynthesis
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for DHFRL1
        dTMP de novo biosynthesis (mitochondrial)
    Trans-sulfuration and one carbon metabolism


    1 Reactome Pathway for DHFRL1
        Metabolism of folate and pterines


    3 Kegg Pathways  (Kegg details for DHFRL1):
        One carbon pool by folate
    Folate biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: DYRL1_HUMAN, Q86XF0
    Pathway: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate:
    step 1/1


    DHFRL1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DHFRL1
    Interactions:

        Search GeneGlobe Interaction Network for DHFRL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for DHFRL1 (Q86XF03 ENSP000003191704) via UniProtKB, MINT, STRING, and/or I2D (see all 23)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPBP2Q926243I2D: score=1 
    CAPZA1ENSP000002631684STRING: ENSP00000263168
    CAPZA2ENSP000003549474STRING: ENSP00000354947
    HAO1ENSP000003680664STRING: ENSP00000368066
    HAO2ENSP000003163394STRING: ENSP00000316339
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006545glycine biosynthetic process IEA--
    GO:0006730one-carbon metabolic process IEA--
    GO:0009165nucleotide biosynthetic process IEA--
    GO:0046105thymidine biosynthetic process IDA--
    GO:0046653tetrahydrofolate metabolic process IDA--

    DHFRL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DHFRL1 (DYRL1)

    8 DrugBank Compounds for DHFRL1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    5-(4-Methoxyphenoxy)-2,4-Quinazolinediamine-- --target--10592235
    5-(4-Morpholin-4-Yl-Phenylsulfanyl)-2,4-Quinazolinediamine-- --target--10592235
    5-Chloryl-2,4,6-Quinazolinetriamine-- --target--10592235
    5-Phenylsulfanyl-2,4-Quinazolinediamine-- --target--10592235
    5-[(4-Methylphenyl)Sulfanyl]-2,4-Quinazolinediamine-- --target--10592235
    5-[4-Tert-Butylphenylsulfanyl]-2,4-Quinazolinediamine-- --target--10592235
    7-(1-ETHYL-PROPYL)-7H-PYRROLO-[3,2-F]QUINAZOLINE-1,3-DIAMINE-- --target--10592235
    7-[2-METHOXY-1-(METHOXYMETHYL)ETHYL]-7H-PYRROLO[3,2-F] QUINAZOLINE-1,3-DIAMINE-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DHFRL1 gene (2 alternative transcripts): 
    NM_001195643.1  NM_176815.4  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481631 ENST00000314636(uc003dri.3) ENST00000394221(uc003drj.3)
    ENST00000461173 ENST00000496983
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    Selected AceView cDNA sequences (see all 48):

    F02761 AW296437 CA395305 AI754268 AW104373 BQ184956 AL832912 AA701106 
    BM671658 BX092090 CR606902 BC045541 CK004653 CB853522 AI271794 CD105434 
    AW500760 N39280 BQ706863 AA516401 AK122674 AA664231 AW198109 AI093830 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DHFRL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGTAACTA
    DHFRL1 Expression
    About this image

    DHFRL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DHFRL1 Protein Expression

    UniProtKB/Swiss-Prot: DYRL1_HUMAN, Q86XF0
    Tissue specificity: Expressed in numerous cell lines

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DHFRL1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves DHFR6
    Gallus gallus dihydrofolate reductase (DHFR), mRNA...
    68(a)
    1 → many
    Z(63876645-63893410)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    71(a)
    1 → many
    2(17183439-17203894)
    zebrafish
    (Danio rerio)
    Actinopterygii dhfr6
    dihydrofolate reductase
    57(a)
    1 → many
    5(27782862-27791037) ENSDARG00000004251
    fruit fly
    (Drosophila melanogaster)
    Insecta Dhfr6
    Dihydrofolate reductase
    46(a)
    1 → many
    3R(12306921-12307601)
    worm
    (Caenorhabditis elegans)
    Secernentea dhfr-16
    Protein DHFR-1 (dhfr-1) mRNA, complete cds
    32(a)
    1 → many
    I(8736067-8737035) WBGene00007974
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DFR16
    Dihydrofolate reductase, part of the dTTP biosynth...
    29(a)
    1 → many
    XV(780906-781541) YOR236W
            Species with no ortholog for DHFRL1

    ENSEMBL Gene Tree for DHFRL1 (if available)
    TreeFam Gene Tree for DHFRL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DHFRL1 gene
    DHFR2  
    2 SIMAP similar genes for DHFRL1 using alignment to 2 protein entries:     DYRL1_HUMAN (see all proteins):
    DHFR    DYR

    DHFRL1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DHFRL1
    PGOHUM00000239221


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DHFRL1 (see all 59)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1825504981,2
    --93776464(+) TCACTC/TGGGGA 2 -- int10--------
    rs1446978641,2
    --93776643(+) CACCTA/GTAGAT 2 -- int10--------
    rs1854457511,2
    --93776662(+) ATGAGC/TGGTAA 2 -- int10--------
    rs1897560471,2
    --93776701(+) GAAAAC/TCTACC 2 -- int10--------
    rs104542131,2
    C,F,A,H--93776736(+) GCATTA/GTAAGG 2 -- int119Minor allele frequency- G:0.06NS EA NA 2292
    rs2019020001,2
    --93776829(+) ATGTG-/ATAAA 
            
    ATTAA
    2 -- ut310--------
    rs1450169581,2
    C--93776830(+) TGTGA-/TAAAAT
            
    TAATA
    2 -- cds10--------
    rs1478334491,2
    --93777018(+) AAGTCC/TTACAA 2 -- ut310--------
    rs1840809001,2
    C--93777061(+) GGAAAA/GCACTT 2 -- ut310--------
    rs348613261,2
    C,F--93777063(+) AAAGCC/ACTTTT 2 -- ut312Minor allele frequency- A:0.50NA 4

    HapMap Linkage Disequilibrium report for DHFRL1 (93766680 - 93782233 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DHFRL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv877162CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DHFRL1
    DNA2.0 Custom Variant and Variant Library Synthesis for DHFRL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    3 diseases for DHFRL1:    
    About MalaCards
    meningioma    pneumonia    tuberculosis


    DHFRL1 for disorders           About GeneDecksing


    Export disorders for DHFRL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DHFRL1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with DHFRL1)
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    1. Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria. (PubMed id 21876188)1, 2 Anderson D.D.... Stover P.J. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    2. The former annotated human pseudogene dihydrofolate reductase-like 1 (DHFRL1) is expressed and functional. (PubMed id 21876184)1, 2 McEntee G.... Parle-McDermott A. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (amp 2011)
    6. Polymorphisms of methionine metabolism and susceptibility to meningioma formation: laboratory investigation. (PubMed id 18447718)1 Semmler A....Linnebank M. (J. Neurosurg. 2008)
    7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (Nucleic Acids Res. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 200895 HGNC: 27309 AceView: LOC200895 Ensembl:ENSG00000178700 euGenes: HUgn200895
    ECgene: DHFRL1 Kegg: 200895 H-InvDB: DHFRL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DHFRL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DHFRL1 gene:
    Search GeneIP for patents involving DHFRL1

    GeneCards and IP:
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