Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DHFRL1 Gene

Aliases for DHFRL1 Gene

  • Dihydrofolate Reductase Like 1 2 3 5
  • Dihydrofolate Reductase-Like Protein 1 3 4
  • Dihydrofolate Reductase Pseudogene 4 2 3
  • Dihydrofolate Reductase-Like 1 2 3
  • EC 1.5.1.3 4 63
  • DHFRP4 3 4

External Ids for DHFRL1 Gene

Previous HGNC Symbols for DHFRL1 Gene

  • DHFRP4

Previous GeneCards Identifiers for DHFRL1 Gene

  • GC03M095260
  • GC03M093766
  • GC03M091139

Summaries for DHFRL1 Gene

GeneCards Summary for DHFRL1 Gene

DHFRL1 (Dihydrofolate Reductase Like 1) is a Protein Coding gene. Among its related pathways are Folate biosynthesis and Metabolism. GO annotations related to this gene include mRNA binding and dihydrofolate reductase activity. An important paralog of this gene is DHFR.

UniProtKB/Swiss-Prot for DHFRL1 Gene

  • Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHFRL1 Gene

Genomics for DHFRL1 Gene

Regulatory Elements for DHFRL1 Gene

Enhancers for DHFRL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DHFRL1 on UCSC Golden Path with GeneCards custom track

Promoters for DHFRL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DHFRL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DHFRL1 Gene

Chromosome:
3
Start:
94,047,836 bp from pter
End:
94,063,389 bp from pter
Size:
15,554 bases
Orientation:
Minus strand

Genomic View for DHFRL1 Gene

Genes around DHFRL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHFRL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHFRL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHFRL1 Gene

Proteins for DHFRL1 Gene

  • Protein details for DHFRL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XF0-DYRL1_HUMAN
    Recommended name:
    Dihydrofolate reductase, mitochondrial
    Protein Accession:
    Q86XF0
    Secondary Accessions:
    • D3DN30
    • Q6P4I9

    Protein attributes for DHFRL1 Gene

    Size:
    187 amino acids
    Molecular mass:
    21620 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DHFRL1 Gene

Proteomics data for DHFRL1 Gene at MOPED

Selected DME Specific Peptides for DHFRL1 Gene

Post-translational modifications for DHFRL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHFRL1 Gene

Domains & Families for DHFRL1 Gene

Protein Domains for DHFRL1 Gene

Suggested Antigen Peptide Sequences for DHFRL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86XF0

UniProtKB/Swiss-Prot:

DYRL1_HUMAN :
  • Contains 1 DHFR (dihydrofolate reductase) domain.
  • Belongs to the dihydrofolate reductase family.
Domain:
  • Contains 1 DHFR (dihydrofolate reductase) domain.
Family:
  • Belongs to the dihydrofolate reductase family.
genes like me logo Genes that share domains with DHFRL1: view

No data available for Gene Families for DHFRL1 Gene

Function for DHFRL1 Gene

Molecular function for DHFRL1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=209 uM for dihydrofolate {ECO:0000269 PubMed:21876184}; KM=20 uM for NADPH {ECO:0000269 PubMed:21876184};
UniProtKB/Swiss-Prot CatalyticActivity:
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
UniProtKB/Swiss-Prot Function:
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR.

Enzyme Numbers (IUBMB) for DHFRL1 Gene

genes like me logo Genes that share phenotypes with DHFRL1: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHFRL1 Gene

Localization for DHFRL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHFRL1 Gene

Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHFRL1 Gene COMPARTMENTS Subcellular localization image for DHFRL1 gene
Compartment Confidence
mitochondrion 5
extracellular 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for DHFRL1 Gene

Pathways & Interactions for DHFRL1 Gene

genes like me logo Genes that share pathways with DHFRL1: view

UniProtKB/Swiss-Prot Q86XF0-DYRL1_HUMAN

  • Pathway: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.

Interacting Proteins for DHFRL1 Gene

Gene Ontology (GO) - Biological Process for DHFRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006730 one-carbon metabolic process IEA --
GO:0009165 nucleotide biosynthetic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DHFRL1: view

No data available for SIGNOR curated interactions for DHFRL1 Gene

Drugs & Compounds for DHFRL1 Gene

(15) Drugs for DHFRL1 Gene - From: DrugBank, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR, Cytotoxic agent 1466
Pralatrexate Approved Pharma Antifolate,a folate analog, RFC-1 targeted DHFR inhibitor 0
Folic Acid Approved Nutra 4079
Tetrahydrofolic acid Approved Nutra 0
5-(4-Methoxyphenoxy)-2,4-Quinazolinediamine Experimental Pharma Target 0

(3) Additional Compounds for DHFRL1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6

(2) ApexBio Compounds for DHFRL1 Gene

Compound Action Cas Number
Methotrexate Folate antagonist,inhibits DFHR 1959-05-2
Pralatrexate Antifolate,a folate analog 146464-95-1
genes like me logo Genes that share compounds with DHFRL1: view

Transcripts for DHFRL1 Gene

Unigene Clusters for DHFRL1 Gene

Dihydrofolate reductase-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHFRL1 Gene

No ASD Table

Relevant External Links for DHFRL1 Gene

GeneLoc Exon Structure for
DHFRL1
ECgene alternative splicing isoforms for
DHFRL1

Expression for DHFRL1 Gene

mRNA expression in normal human tissues for DHFRL1 Gene

SOURCE GeneReport for Unigene cluster for DHFRL1 Gene Hs.718516

mRNA Expression by UniProt/SwissProt for DHFRL1 Gene

Q86XF0-DYRL1_HUMAN
Tissue specificity: Expressed in numerous cell lines.
genes like me logo Genes that share expression patterns with DHFRL1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DHFRL1 Gene

Orthologs for DHFRL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DHFRL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHFRL1 35
  • 99.28 (n)
  • 97.85 (a)
DHFRL1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DHFR 36
  • 83 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 88 (a)
ManyToMany
-- 36
  • 84 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Dhfr 36
  • 87 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves DHFR 36
  • 68 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 71 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8788 35
zebrafish
(Danio rerio)
Actinopterygii dhfr 36
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Dhfr 36
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dhfr-1 36
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DFR1 36
  • 29 (a)
OneToMany
Species with no ortholog for DHFRL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DHFRL1 Gene

ENSEMBL:
Gene Tree for DHFRL1 (if available)
TreeFam:
Gene Tree for DHFRL1 (if available)

Paralogs for DHFRL1 Gene

Paralogs for DHFRL1 Gene

(2) SIMAP similar genes for DHFRL1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for DHFRL1 Gene

genes like me logo Genes that share paralogs with DHFRL1: view

Variants for DHFRL1 Gene

Sequence variations from dbSNP and Humsavar for DHFRL1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_061135 -
rs10454213 -- 94,057,892(+) GCATT(A/G)TAAGG downstream-variant-500B
rs11545820 -- 94,059,370(+) CACAA(C/T)GCCCA utr-variant-3-prime
rs11545821 -- 94,059,358(+) ACAGG(C/T)GCGTG utr-variant-3-prime
rs11545822 -- 94,059,495(+) ACTCC(C/T)GGCCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DHFRL1 Gene

Variant ID Type Subtype PubMed ID
nsv877162 CNV Gain 21882294

Variation tolerance for DHFRL1 Gene

Residual Variation Intolerance Score: 53.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.35; 76.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHFRL1 Gene

HapMap Linkage Disequilibrium report
DHFRL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHFRL1 Gene

Disorders for DHFRL1 Gene

Relevant External Links for DHFRL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHFRL1

No disorders were found for DHFRL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHFRL1 Gene

Publications for DHFRL1 Gene

  1. Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria. (PMID: 21876188) Anderson D.D. … Stover P.J. (Proc. Natl. Acad. Sci. U.S.A. 2011) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Insight into the molecular mechanism about lowered dihydrofolate binding affinity to dihydrofolate reductase-like 1 (DHFRL1). (PMID: 24122410) Gao J. … Ji M. (J Mol Model 2013) 3
  5. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PMID: 21044950) Lee O.H. … Songyang Z. (Mol. Cell Proteomics 2011) 3

Products for DHFRL1 Gene

Sources for DHFRL1 Gene

Content