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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DHDH Gene

protein-coding   GIFtS: 54
GCID: GC19P049436

dihydrodiol dehydrogenase (dimeric)
 Explore 20 diseases affiliated with
DHDH via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DHDH    

Aliases
for DHDH gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dihydrodiol Dehydrogenase (Dimeric)1 2     Trans-1,2-Dihydrobenzene-1,2-Diol Dehydrogenase2
HUM2DD1 2     EC 1.1.1.1793
2DD2 3     EC 1.3.1.203
D-Xylose 1-Dehydrogenase2 3     Hum2DD3
D-Xylose-NADP Dehydrogenase2 3     Dimeric Dihydrodiol Dehydrogenase3
3-Deoxyglucosone Reductase2     

External Ids:    HGNC: 178871   Entrez Gene: 272942   Ensembl: ENSG000001048087   OMIM: 6063775   UniProtKB: Q9UQ103   

Export aliases for DHDH gene to outside databases

Previous GC identifers: GC19P050095 GC19P049805 GC19P054112 GC19P054128 GC19P045813


Summaries
for DHDH gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DHDH:
This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in
mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the
NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a
dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate
specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. (provided by RefSeq, Jul 2008)




Genomic Views
for DHDH gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DHDH gene promoter:
         ER-alpha   NRSF form 1   STAT5A   AP-4   Nkx5-1   NRSF form 2   C/EBPalpha   AREB6   COMP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DHDH promoter sequence
   Search SABiosciences Chromatin IP Primers for DHDH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHDH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

DHDH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHDH gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P049436:  view genomic region     (about GC identifiers)

Start:
 49,436,939 bp from pter      End:
 49,448,226 bp from pter
Size:
 11,288 bases      Orientation:
 plus strand

Proteins
for DHDH gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DHDH_HUMAN, Q9UQ10 (See protein sequence)
Recommended Name: Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase  
Size: 334 amino acids; 36382 Da
Subunit: Homodimer

Explore the universe of human proteins at neXtProt for DHDH: NX_Q9UQ10

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UQ10

    • DHDH Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055290.1  
    ENSEMBL proteins: 
     ENSP00000221403   ENSP00000428935   ENSP00000428672   ENSP00000430360  

    Human Recombinant Protein Products: 
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    Novus Biologicals DHDH Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DHDH

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----


    DHDH for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DHDH

    Protein Domains /
    Families
    for DHDH gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DHDH for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000683 Oxidoreductase_N
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q9UQ10

    ProtoNet protein and cluster: Q9UQ10

    1 Blocks protein family: IPB000683 Oxidoreductase

    UniProtKB/Swiss-Prot: DHDH_HUMAN, Q9UQ10
    Similarity: Belongs to the Gfo/Idh/MocA family


    Function
    for DHDH gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DHDH_HUMAN, Q9UQ10
    Catalytic activity: Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH
    Catalytic activity: D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH

    Enzyme Numbers (IUBMB): EC 1.3.1.201 EC 1.1.1.1791

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DHDH (see all 4)
    OriGene shRNA RFP: DHDH
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0008746NAD(P)+ transhydrogenase activity TAS10477285
    GO:0009055electron carrier activity TAS10477285
    GO:0016491oxidoreductase activity ----
    GO:0047115trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity IEA--


    DHDH for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for DHDH:
     Nuclear pre-40S maturation def 


    Pathways & Interactions
    for DHDH gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Pentose and glucuronate interconversions
    		Pentose and glucuronate interconversions1.00
    2Drug metabolism - cytochrome P450
    		Metabolism of xenobiotics by cytochrome P4500.73

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    2         Kegg Pathways  (Kegg details for DHDH):
        Pentose and glucuronate interconversions
    Metabolism of xenobiotics by cytochrome P450


    DHDH for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DHDH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for DHDH (ENSP000002214034) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKR1B1ENSP000002859304STRING: ENSP00000285930
    CYP1A1ENSP000003690504STRING: ENSP00000369050
    CYP2B6ENSP000003246484STRING: ENSP00000324648
    EPHX1ENSP000002721674STRING: ENSP00000272167
    CYP1A2ENSP000003420074STRING: ENSP00000342007
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS10477285
    GO:0042843D-xylose catabolic process IEA--


    DHDH for ontologies           About GeneDecksing



    Drugs & Compounds
    for DHDH gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DHDH for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DHDH

    6 HMDB Compounds for DHDH    About this table
    CompoundSynonyms CAS #PubMed Ids
    D-Xylono-1,5-lactoneD-Xylonolactone (see all 2)----
    D-Xylosed-Xylose (see all 8)58-86-6--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    Pyrocatechol1,2-Dihydroxybenzene (see all 20)120-80-9--
    trans-1,2-Dihydrobenzene-1,2-diolArene diol (see all 7)103302-38-1--
    10/28 Novoseek chemical compound relationships for DHDH gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    3alpha-hydroxysteroid 92.9 24 1639345 (2), 10619355 (2), 7735258 (2), 7948008 (2) (see all 17)
    naphthalene-1,2-dihydrodiol 87.5 2 9884310 (1)
    chlordecone 84 1 7789999 (1)
    nadp+ 74.9 1 1394622 (1)
    dicoumarol 71.8 1 1722672 (1)
    1,2-naphthoquinone 71.5 2 9109344 (1), 9884310 (1)
    hydrocarbons 70 13 9973208 (2), 12579257 (1), 11752800 (1), 12204825 (1) (see all 12)
    ethacrynic acid 69.7 3 7515059 (1), 7488239 (1), 9406235 (1)
    o-quinone 67.3 1 11453732 (1)
    3-deoxyglucosone 63.6 6 1953687 (3), 8274014 (2)

    Search CenterWatch for drugs/clinical trials and news about DHDH 

    Transcripts
    for DHDH gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DHDH gene: 
    NM_014475.3  

    Unigene Cluster for DHDH:

    Dihydrodiol dehydrogenase (dimeric)
    Hs.631555  [show with all ESTs]
    Unigene Representative Sequence: BM454993
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000221403(uc002ple.1) ENST00000523250 ENST00000522614 ENST00000520557


    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: DHDH
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DHDH
    Clone
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    Primer
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    Additional cDNA sequence: 

    AB021933.1 BC032730.1 

    3 DOTS entries:

    DT.40129584  DT.40126733  DT.92417156 

    3 AceView cDNA sequences:

    AB021933 BC032730 NM_014475 

    GeneLoc Exon Structure


    Expression
    for DHDH gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DHDH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTTATGAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DHDH expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DHDH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DHDH

    SOURCE GeneReport for Unigene cluster: Hs.631555

    UniProtKB/Swiss-Prot: DHDH_HUMAN, Q9UQ10
    Tissue specificity: Small intestine

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    In Situ
    Assay Products:     
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    Orthologs
    for DHDH gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for DHDH gene from 7/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dhdh1 , 5 dihydrodiol dehydrogenase (dimeric)1, 5 78.58(n)1
    78.98(a)1    		   7 (29.32 cM)5
    717551  NM_027903.31  NP_082179.11 
     454729565 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 3)    		 --
    		 52(a)
    51(a)
    (see all 3)    		 many → 1
    many → 1
    (see all 3)    		 GL343355.1(469756-481249)
    GL343355.1(491364-497715)
    zebrafish
    (Danio rerio)    		 Actinopterygii BQ260196.12   -- 78.65(n)    BQ260196.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG36091 , 3 CG36091 42(a)
    (best of 3)3
    53.6(n)1
    43.47(a)1    		   22E13
    334211  NM_001201755.11  NP_001188684.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G661306
    AT4G096706
    (see all 3)    		 uncharacterized oxidoreductase
    (see all 3)    		 20(a)
    19(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 1(24614962-24616930)
    4(6107150-6109122)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 uncharacterized oxidoreductase, putative, expresse...
    uncharacterized oxidoreductase, putative, expresse...
    		 26(a)
    14(a)
    		 possible ortholog
    possible ortholog
    		 10(13636978-13638527)
    10(13640032-13642913)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria ygjR6
    		 predicted NAD(P)-binding dehydrogenase
    		 20(a)
    		 1 ↔ 1
    		 Chromosome(3235333-3236319)


    ENSEMBL Gene Tree for DHDH (if available)
    TreeFam Gene Tree for DHDH (if available) 

    Paralogs
    for DHDH gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for DHDH gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/294 NCBI SNPs in DHDH are shown (see all 294)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs72521591,2
    		C,H,--49434945(+) ccctgC/Tcttga 1 -- us2k16Minor allele frequency- T:0.02NS EA WA 538
    rs1812070091,2
    		--49435102(+) TGGGCA/GTGGTG 1 -- us2k10--------
    rs1865234971,2
    		--49435150(+) GCAGGC/TGGATC 1 -- us2k10--------
    rs1898014051,2
    		--49435263(+) CCCAGC/TTACTC 1 -- us2k10--------
    rs1495461571,2
    		--49435277(+) AGGCTC/GAGGTA 1 -- us2k10--------
    rs1133840821,2
    		--49435365(+) TGACAG/CAGCGA 1 -- us2k12Minor allele frequency- C:0.04CSA WA 120
    rs726262251,2
    		C,--49435406(+) CAACAG/ACAACA 1 -- us2k15Minor allele frequency- A:0.35WA CSA NA EA 361
    rs1431218611,2
    		--49435449(+) TTGTAA/GTCCCA 1 -- us2k10--------
    rs1823272251,2
    		--49435476(+) AGGCAA/GGCAAA 1 -- us2k10--------
    rs1482395941,2
    		--49435484(+) AAATCA/GCAAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DHDH (49436939 - 49448226 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for DHDH
         3 CNVs: 5108 5107 32261

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DHDH
    DNA2.0 Custom Variant and Variant Library Synthesis for DHDH

    Disorders / Diseases
    for DHDH gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DHDH for disorders           About GeneDecksing

    OMIM gene information: 606377    OMIM disorders: --

    20 diseases for DHDH:    About MalaCards
    esophageal squamous cell carcinoma    squamous cell carcinoma    ovarian carcinoma    carcinoma
    lung cancer    vaccinia    lung adenocarcinoma    pulmonary disease
    adenocarcinoma    hepatocellular carcinoma    cervical cancer    esophagitis
    cervicitis    colon cancer    ovarian cancer    gastric cancer
    lung carcinoma    pneumonia    hypoxia    hepatitis

    8 Novoseek disease relationships for DHDH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian carcinoma 52.6 3 17661040 (1), 11842089 (1), 15138708 (1)
    nsclc 42.3 6 11289154 (2), 17266043 (1), 11956619 (1)
    cancer lung 24 2 17163506 (2)
    cancer 6.31 1 18214064 (1)
    tumors 5.19 2 17163506 (1), 15138708 (1)
    carcinoma squamous cell 0 3 15197778 (2), 16361083 (1)
    adenocarcinoma 0 2 16886619 (1), 11925926 (1)
    carcinoma 0 1 17009030 (1)

    Human Genome Epidemiology (HuGE) Navigator: DHDH (5 documents)

    Export disorders for DHDH gene to outside databases

    Publications
    for DHDH gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DHDH gene, integrated from 9 sources (see all 97):
    (articles sorted by number of sources associating them with DHDH)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequencing of the cDNA species for mammalian dimeric dihydrodiol dehydrogenases. (PubMed id 10477285)1, 2, 3, 9 Arimitsu E.... Hara A. (1999)
    2. Identity of dimeric dihydrodiol dehydrogenase as NADP(+)-dependent D-xylose dehydrogenase in pig liver. (PubMed id 11306093)1, 9 Aoki S....Hara A. (2001)
    3. Roles of His-79 and Tyr-180 of D-xylose/dihydrodiol dehydrogenase in catalytic function. (PubMed id 11097839)1, 9 Asada Y....Hara A. (2000)
    4. Overexpression of dihydrodiol dehydrogenase as a prognostic marker in resected gastric cancer patients. (PubMed id 18600452)1, 9 Chang H.C....Fang H.Y. (2009)
    5. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1 Guey L.T....Malats N. (2010)
    6. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1 Hosgood H.D....Lan Q. (2009)
    7. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1 Shen M....Lan Q. (2009)
    8. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1 Hosgood H.D....Lan Q. (2009)
    9. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1 Hosgood H.D....Lan Q. (2008)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    External Searches for DHDH gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing DHDH gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27294 HGNC: 17887 AceView: DHDH Ensembl:ENSG00000104808 euGenes: HUgn27294
    ECgene: DHDH Kegg: 27294 H-InvDB: DHDH

    Other Databases showing DHDH gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DHDH gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DHDH Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DHDH gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DHDH gene:
    Search GeneIP for patents involving DHDH

    GeneCards and IP:
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