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Aliases for DHDH Gene

Aliases for DHDH Gene

  • Dihydrodiol Dehydrogenase (Dimeric) 2 3
  • D-Xylose-NADP Dehydrogenase 3 4
  • D-Xylose 1-Dehydrogenase 3 4
  • HUM2DD 3 4
  • 2DD 3 4
  • Trans-1,2-Dihydrobenzene-1,2-Diol Dehydrogenase 3
  • Dimeric Dihydrodiol Dehydrogenase 4
  • 3-Deoxyglucosone Reductase 3
  • EC 1.1.1.179 4
  • EC 1.3.1.20 4

External Ids for DHDH Gene

Summaries for DHDH Gene

Entrez Gene Summary for DHDH Gene

  • This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. [provided by RefSeq, Jul 2008]

GeneCards Summary for DHDH Gene

DHDH (Dihydrodiol Dehydrogenase (Dimeric)) is a Protein Coding gene. Diseases associated with DHDH include lung cancer. Among its related pathways are Glucuronidation and Chemical carcinogenesis. GO annotations related to this gene include electron carrier activity and NAD(P)+ transhydrogenase activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHDH Gene

Genomics for DHDH Gene

Genomic Location for DHDH Gene

Start:
48,933,682 bp from pter
End:
48,944,969 bp from pter
Size:
11,288 bases
Orientation:
Plus strand

Genomic View for DHDH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHDH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHDH Gene

Regulatory Elements for DHDH Gene

Proteins for DHDH Gene

  • Protein details for DHDH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQ10-DHDH_HUMAN
    Recommended name:
    Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
    Protein Accession:
    Q9UQ10
    Secondary Accessions:

    Protein attributes for DHDH Gene

    Size:
    334 amino acids
    Molecular mass:
    36382 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for DHDH Gene

Proteomics data for DHDH Gene at MOPED

Post-translational modifications for DHDH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHDH Gene

No data available for DME Specific Peptides for DHDH Gene

Domains for DHDH Gene

Protein Domains for DHDH Gene

UniProtKB/Swiss-Prot:

DHDH_HUMAN
Family:
  • Belongs to the Gfo/Idh/MocA family.:
    • Q9UQ10
genes like me logo Genes that share domains with DHDH: view

No data available for Gene Families for DHDH Gene

Function for DHDH Gene

Molecular function for DHDH Gene

UniProtKB/Swiss-Prot CatalyticActivity: Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH
UniProtKB/Swiss-Prot CatalyticActivity: D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH

Enzyme Numbers (IUBMB) for DHDH Gene

Gene Ontology (GO) - Molecular Function for DHDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008746 NAD(P)+ transhydrogenase activity TAS 10477285
GO:0009055 electron carrier activity TAS 10477285
GO:0016491 oxidoreductase activity --
GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity IEA --
GO:0047837 D-xylose 1-dehydrogenase (NADP+) activity IEA --
genes like me logo Genes that share ontologies with DHDH: view

Phenotypes for DHDH Gene

GenomeRNAi human phenotypes for DHDH:
genes like me logo Genes that share phenotypes with DHDH: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DHDH Gene

Localization for DHDH Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHDH Gene COMPARTMENTS Subcellular localization image for DHDH gene
Compartment Confidence
cytosol 2
extracellular 2
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for DHDH Gene

Pathways for DHDH Gene

genes like me logo Genes that share pathways with DHDH: view

Pathways by source for DHDH Gene

Interacting Proteins for DHDH Gene

Gene Ontology (GO) - Biological Process for DHDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 10477285
GO:0042843 D-xylose catabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DHDH: view

Compounds for DHDH Gene

(6) HMDB Compounds for DHDH Gene

Compound Synonyms Cas Number PubMed IDs
D-Xylono-1,5-lactone
  • D-Xylonolactone
Not Available
D-Xylose
  • d-Xylose
58-86-6
NADP
  • Adenine-nicotinamide dinucleotide phosphate
53-59-8
NADPH
  • 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
53-57-6
Pyrocatechol
  • 1,2-Dihydroxybenzene
120-80-9

(28) Novoseek inferred chemical compound relationships for DHDH Gene

Compound -log(P) Hits PubMed IDs
3alpha-hydroxysteroid 92.9 23
naphthalene-1,2-dihydrodiol 87.5 1
chlordecone 84 1
nadp+ 74.9 1
dicoumarol 71.8 1
genes like me logo Genes that share compounds with DHDH: view

Transcripts for DHDH Gene

mRNA/cDNA for DHDH Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DHDH Gene

Dihydrodiol dehydrogenase (dimeric):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHDH Gene

No ASD Table

Relevant External Links for DHDH Gene

GeneLoc Exon Structure for
DHDH
ECgene alternative splicing isoforms for
DHDH

Expression for DHDH Gene

mRNA expression in normal human tissues for DHDH Gene

mRNA differential expression in normal tissues according to GTEx for DHDH Gene

This gene is overexpressed in Kidney - Cortex (9.7) and Small Intestine - Terminal Ileum (6.1).

SOURCE GeneReport for Unigene cluster for DHDH Gene Hs.631555

mRNA Expression by UniProt/SwissProt for DHDH Gene

Q9UQ10-DHDH_HUMAN
Tissue specificity: Small intestine.
genes like me logo Genes that share expressions with DHDH: view

Orthologs for DHDH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHDH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHDH 36
  • 98.3 (n)
  • 97 (a)
DHDH 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DHDH 36
  • 86.99 (n)
  • 87.69 (a)
DHDH 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DHDH 36
  • 86.93 (n)
  • 86.53 (a)
DHDH 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dhdh 36
  • 78.58 (n)
  • 78.98 (a)
Dhdh 16
Dhdh 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DHDH 37
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dhdh 36
  • 78.51 (n)
  • 77.71 (a)
chicken
(Gallus gallus)
Aves DHDH 37
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 51 (a)
OneToMany
-- 37
  • 51 (a)
OneToMany
-- 37
  • 47 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dhdh 36
  • 58.86 (n)
  • 53.75 (a)
zebrafish
(Danio rerio)
Actinopterygii DHDH (1 of 2) 37
  • 52 (a)
OneToMany
dhdhl 37
  • 46 (a)
OneToMany
zgc:101723 36
  • 58.68 (n)
  • 50 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009945 36
  • 49.35 (n)
  • 43.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13280 37
  • 24 (a)
OneToMany
CG3597 37
  • 37 (a)
OneToMany
CG3609 36
  • 53.6 (n)
  • 43.47 (a)
CG3609 37
  • 42 (a)
OneToMany
CG3597 38
  • 38 (a)
CG3609 38
  • 42 (a)
CG13280 38
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G09670 36
  • 38.57 (n)
  • 26.03 (a)
rice
(Oryza sativa)
Liliopsida Os10g0403700 36
  • 46.69 (n)
  • 29.76 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01704 36
  • 48.83 (n)
  • 39.45 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC513.06c 36
  • 45.43 (n)
  • 37.54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 44 (a)
OneToOne
Species with no ortholog for DHDH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DHDH Gene

ENSEMBL:
Gene Tree for DHDH (if available)
TreeFam:
Gene Tree for DHDH (if available)

Paralogs for DHDH Gene

No data available for Paralogs for DHDH Gene

Variants for DHDH Gene

Sequence variations from dbSNP and Humsavar for DHDH Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2270939 -- 48,939,676(-) ACGAC(A/G)GAAAT synonymous-codon, reference
rs2270940 -- 48,939,478(-) GCCTC(A/G)GAGGC reference, synonymous-codon
rs2270941 - 48,935,106(-) CCACG(C/T)TCGGG missense, reference
rs2270942 -- 48,934,744(-) TTGTG(C/T)GGGGA intron-variant, upstream-variant-2KB
rs3765148 - 48,944,456(-) TGCCC(C/T)GTTGT missense, reference

Structural Variations from Database of Genomic Variants (DGV) for DHDH Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv833855 CNV Loss 17160897
nsv833856 CNV Loss 17160897
nsv833857 CNV Loss 17160897
nsv518164 CNV Loss 19592680
nsv912248 CNV Loss 21882294
nsv521890 CNV Gain 19592680

Relevant External Links for DHDH Gene

HapMap Linkage Disequilibrium report
DHDH
Human Gene Mutation Database (HGMD)
DHDH

Disorders for DHDH Gene

(1) MalaCards Diseases for DHDH Gene

Search for DHDH Gene in MalaCards »

(8) Novoseek inferred disease relationships for DHDH Gene

Disease -log(P) Hits PubMed IDs
ovarian carcinoma 52.6 3
nsclc 42.3 4
cancer lung 24 2
cancer 6.31 1
tumors 5.19 2

Relevant External Links for DHDH

Genetic Association Database (GAD)
DHDH
Human Genome Epidemiology (HuGE) Navigator
DHDH
genes like me logo Genes that share disorders with DHDH: view

No data available for UniProtKB/Swiss-Prot for DHDH Gene

Publications for DHDH Gene

  1. Cloning and sequencing of the cDNA species for mammalian dimeric dihydrodiol dehydrogenases. (PMID: 10477285) Arimitsu E. … Hara A. (Biochem. J. 1999) 2 3 4 23
  2. Roles of His-79 and Tyr-180 of D-xylose/dihydrodiol dehydrogenase in catalytic function. (PMID: 11097839) Asada Y. … Hara A. (Biochem. Biophys. Res. Commun. 2000) 3 23
  3. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PMID: 18676680) Hosgood H.D. … Lan Q. (Carcinogenesis 2008) 3 49
  4. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M. … Lan Q. (Environ. Mol. Mutagen. 2009) 3 49
  5. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PMID: 19625176) Hosgood H.D. … Lan Q. (Respir Med 2009) 3 49

Products for DHDH Gene

Sources for DHDH Gene

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