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DHDH Gene

protein-coding   GIFtS: 55
GCID: GC19P049436

Dihydrodiol Dehydrogenase (Dimeric)

  See DHDH-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dihydrodiol Dehydrogenase (Dimeric)1 2     Trans-1,2-Dihydrobenzene-1,2-Diol Dehydrogenase2
2DD2 3     EC 1.1.1.1793
D-Xylose 1-Dehydrogenase2 3     EC 1.3.1.203
D-Xylose-NADP Dehydrogenase2 3     Hum2DD3
3-Deoxyglucosone Reductase2     Dimeric Dihydrodiol Dehydrogenase3
HUM2DD2     

External Ids:    HGNC: 178871   Entrez Gene: 272942   Ensembl: ENSG000001048087   OMIM: 6063775   UniProtKB: Q9UQ103   

Export aliases for DHDH gene to outside databases

Previous GC identifers: GC19P050095 GC19P049805 GC19P054112 GC19P054128 GC19P045813


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DHDH Gene:
This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple
forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze
the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme
is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high
substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. (provided by
RefSeq, Jul 2008)

GeneCards Summary for DHDH Gene:
DHDH (dihydrodiol dehydrogenase (dimeric)) is a protein-coding gene. Diseases associated with DHDH include lung cancer. GO annotations related to this gene include NAD(P)+ transhydrogenase activity and electron carrier activity.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DHDH gene promoter:
         ER-alpha   NRSF form 1   STAT5A   AP-4   Nkx5-1   NRSF form 2   C/EBPalpha   AREB6   COMP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDHDH promoter sequence
   Search Chromatin IP Primers for DHDH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DHDH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

DHDH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHDH gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P049436:  view genomic region     (about GC identifiers)

Start:
49,436,939 bp from pter      End:
49,448,226 bp from pter
Size:
11,288 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DHDH_HUMAN, Q9UQ10 (See protein sequence)
Recommended Name: Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase  
Size: 334 amino acids; 36382 Da
Subunit: Homodimer

Explore the universe of human proteins at neXtProt for DHDH: NX_Q9UQ10

Explore proteomics data for DHDH at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DHDH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055290.1  
    ENSEMBL proteins: 
     ENSP00000221403   ENSP00000428935   ENSP00000428672   ENSP00000430360  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000683 Oxidoreductase_N
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q9UQ10

    ProtoNet protein and cluster: Q9UQ10

    1 Blocks protein domain: IPB000683 Oxidoreductase

    UniProtKB/Swiss-Prot: DHDH_HUMAN, Q9UQ10
    Similarity: Belongs to the Gfo/Idh/MocA family


    Find genes that share domains with DHDH           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DHDH_HUMAN, Q9UQ10
    Catalytic activity: Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH
    Catalytic activity: D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH

         Enzyme Numbers (IUBMB): EC 1.3.1.201 EC 1.1.1.1791

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008746NAD(P)+ transhydrogenase activity TAS10477285
    GO:0009055electron carrier activity TAS10477285
    GO:0016491oxidoreductase activity ----
    GO:0047115trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity IEA--
    GO:0047837D-xylose 1-dehydrogenase (NADP+) activity IEA--
         
    Find genes that share ontologies with DHDH           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DHDH:
     Nuclear pre-40S maturation def 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DHDH
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    extracellular2
    plasma membrane2
    cytoskeleton1
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DHDH About    
    See pathways by source

    SuperPathContained pathways About
    1Chemical carcinogenesis
    Metabolism of xenobiotics by cytochrome P4500.71
    2Glucuronidation
    Pentose and glucuronate interconversions0.61


    Find genes that share SuperPaths with DHDH           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Kegg Pathways  (Kegg details for DHDH):
        Pentose and glucuronate interconversions
    Metabolism of xenobiotics by cytochrome P450

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DHDH
    Interactions:

        Search GeneGlobe Interaction Network for DHDH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DHDH (ENSP000002214034) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKR1B1ENSP000002859304STRING: ENSP00000285930
    CYP1A1ENSP000003690504STRING: ENSP00000369050
    CYP2B6ENSP000003246484STRING: ENSP00000324648
    EPHX1ENSP000002721674STRING: ENSP00000272167
    CYP1A2ENSP000003420074STRING: ENSP00000342007
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS10477285
    GO:0042843D-xylose catabolic process IEA--

    Find genes that share ontologies with DHDH           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DHDH

    6 HMDB Compounds for DHDH    About this table
    CompoundSynonyms CAS #PubMed Ids
    D-Xylono-1,5-lactoneD-Xylonolactone (see all 2)----
    D-Xylosed-Xylose (see all 8)58-86-6--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    Pyrocatechol1,2-Dihydroxybenzene (see all 20)120-80-9--
    trans-1,2-Dihydrobenzene-1,2-diolArene diol (see all 7)103302-38-1--

    Selected Novoseek inferred chemical compound relationships for DHDH gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    3alpha-hydroxysteroid 92.9 24 1639345 (2), 10619355 (2), 7735258 (2), 7948008 (2) (see all 17)
    naphthalene-1,2-dihydrodiol 87.5 2 9884310 (1)
    chlordecone 84 1 7789999 (1)
    nadp+ 74.9 1 1394622 (1)
    dicoumarol 71.8 1 1722672 (1)
    1,2-naphthoquinone 71.5 2 9109344 (1), 9884310 (1)
    hydrocarbons 70 13 9973208 (2), 12579257 (1), 11752800 (1), 12204825 (1) (see all 12)
    ethacrynic acid 69.7 3 7515059 (1), 7488239 (1), 9406235 (1)
    o-quinone 67.3 1 11453732 (1)
    3-deoxyglucosone 63.6 6 1953687 (3), 8274014 (2)



    Find genes that share compounds with DHDH           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DHDH gene: 
    NM_014475.3  

    Unigene Cluster for DHDH:

    Dihydrodiol dehydrogenase (dimeric)
    Hs.631555  [show with all ESTs]
    Unigene Representative Sequence: BM454993
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000221403(uc002ple.1) ENST00000523250 ENST00000522614 ENST00000520557

    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat DHDH
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    Additional mRNA sequence: 

    AB021933.1 BC032730.1 

    3 DOTS entries:

    DT.40129584  DT.40126733  DT.92417156 

    3 AceView cDNA sequences:

    AB021933 BC032730 NM_014475 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DHDH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTATGAGG
    DHDH Expression
    About this image

    DHDH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DHDH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631555

    UniProtKB/Swiss-Prot: DHDH_HUMAN, Q9UQ10
    Tissue specificity: Small intestine

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DHDH gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dhdh1 , 5 dihydrodiol dehydrogenase (dimeric)1, 5 78.58(n)1
    78.98(a)1
      7 (29.32 cM)5
    717551  NM_027903.31  NP_082179.11 
     454729565 
    chicken
    (Gallus gallus)
    Aves DHDH6
    dihydrodiol dehydrogenase (dimeric)
    34(a)
    1 ↔ 1
    JH376330.1(21-3262)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    51(a)
    51(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    GL343355.1(491364-497715)
    GL343355.1(469329-482337)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dhdh1 dihydrodiol dehydrogenase (dimeric) 58.86(n)
    53.75(a)
      100145807  NM_001127165.1  NP_001120637.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BQ260196.12   -- 78.65(n)    BQ260196.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG36091 , 3 CG36091 42(a)
    (best of 3)3
    53.6(n)1
    43.47(a)1
      22E13
    334211  NM_001201755.21  NP_001188684.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G096701 AT4G09670 38.57(n)
    26.03(a)
      826553  NM_117035.3  NP_192705.1 
    rice
    (Oryza sativa)
    Liliopsida Os10g04037001 Os10g0403700 46.69(n)
    29.76(a)
      4348576  NM_001071089.1  NP_001064554.1 


    ENSEMBL Gene Tree for DHDH (if available)
    TreeFam Gene Tree for DHDH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DHDH (see all 386)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs72521591,2
    C,F,H--49434945(+) ccctgC/Tcttga 1 -- us2k16Minor allele frequency- T:0.02NS EA WA 538
    rs1812070091,2
    --49435102(+) TGGGCA/GTGGTG 1 -- us2k10--------
    rs1865234971,2
    --49435150(+) GCAGGC/TGGATC 1 -- us2k10--------
    rs1898014051,2
    --49435263(+) CCCAGC/TTACTC 1 -- us2k10--------
    rs1495461571,2
    --49435277(+) AGGCTC/GAGGTA 1 -- us2k10--------
    rs1133840821,2
    C,F--49435365(+) TGACAG/CAGCGA 1 -- us2k12Minor allele frequency- C:0.04CSA WA 120
    rs726262251,2
    C--49435406(+) CAACAG/ACAACA 1 -- us2k15Minor allele frequency- A:0.35WA CSA NA EA 361
    rs1431218611,2
    --49435449(+) TTGTAA/GTCCCA 1 -- us2k10--------
    rs1823272251,2
    --49435476(+) AGGCAA/GGCAAA 1 -- us2k10--------
    rs1482395941,2
    C--49435484(+) AAATCA/GCAAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DHDH (49436939 - 49448226 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for DHDH:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv518164CNV Loss19592680
    nsv833855CNV Loss17160897
    nsv833857CNV Loss17160897
    nsv833856CNV Loss17160897
    nsv912248CNV Loss21882294
    nsv521890CNV Gain19592680
    nsv9739CNV Gain+Loss18304495

    Human Gene Mutation Database (HGMD): DHDH
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DHDH
    DNA2.0 Custom Variant and Variant Library Synthesis for DHDH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606377    OMIM disorders: --

    1 disease for DHDH:    
    About MalaCards
    lung cancer


    Find genes that share disorders with DHDH           About GenesLikeMe

    8 Novoseek inferred disease relationships for DHDH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian carcinoma 52.6 3 17661040 (1), 11842089 (1), 15138708 (1)
    nsclc 42.3 6 11289154 (2), 17266043 (1), 11956619 (1)
    cancer lung 24 2 17163506 (2)
    cancer 6.31 1 18214064 (1)
    tumors 5.19 2 17163506 (1), 15138708 (1)
    carcinoma squamous cell 0 3 15197778 (2), 16361083 (1)
    adenocarcinoma 0 2 16886619 (1), 11925926 (1)
    carcinoma 0 1 17009030 (1)

    Genetic Association Database (GAD): DHDH
    Human Genome Epidemiology (HuGE) Navigator: DHDH (5 documents)

    Export disorders for DHDH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DHDH gene, integrated from 10 sources (see all 98):
    (articles sorted by number of sources associating them with DHDH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequencing of the cDNA species for mammalian dimeric dihydrodiol dehydrogenases. (PubMed id 10477285)1, 2, 3, 9 Arimitsu E.... Hara A. (Biochem. J. 1999)
    2. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    3. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    4. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    5. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    6. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    7. Identity of dimeric dihydrodiol dehydrogenase as NADP(+)-dependent D-xylose dehydrogenase in pig liver. (PubMed id 11306093)1, 9 Aoki S....Hara A. (Chem. Biol. Interact. 2001)
    8. Roles of His-79 and Tyr-180 of D-xylose/dihydrodiol dehydrogenase in catalytic function. (PubMed id 11097839)1, 9 Asada Y....Hara A. (Biochem. Biophys. Res. Commun. 2000)
    9. Overexpression of dihydrodiol dehydrogenase as a prognostic marker in resected gastric cancer patients. (PubMed id 18600452)1, 9 Chang H.C....Fang H.Y. (Dig. Dis. Sci. 2009)
    10. Common variants of the ALDH2 and DHDH genes and the risk of Dupuytren's disease. (PubMed id 23303836)1 Zyluk A....Puchalski P. (J Hand Surg Eur Vol 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27294 HGNC: 17887 AceView: DHDH Ensembl:ENSG00000104808 euGenes: HUgn27294
    ECgene: DHDH Kegg: 27294 H-InvDB: DHDH

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DHDH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DHDH gene:
    Search GeneIP for patents involving DHDH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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