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Aliases for DHDH Gene

Aliases for DHDH Gene

  • Dihydrodiol Dehydrogenase 2 3 5
  • Trans-1,2-Dihydrobenzene-1,2-Diol Dehydrogenase 2 3
  • D-Xylose-NADP Dehydrogenase 3 4
  • D-Xylose 1-Dehydrogenase 3 4
  • HUM2DD 3 4
  • 2DD 3 4
  • Dihydrodiol Dehydrogenase (Dimeric) 3
  • Dimeric Dihydrodiol Dehydrogenase 4
  • 3-Deoxyglucosone Reductase 3
  • EC 4
  • EC 4

External Ids for DHDH Gene

Previous GeneCards Identifiers for DHDH Gene

  • GC19P050095
  • GC19P049805
  • GC19P054112
  • GC19P054128
  • GC19P049436
  • GC19P045813

Summaries for DHDH Gene

Entrez Gene Summary for DHDH Gene

  • This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. [provided by RefSeq, Jul 2008]

GeneCards Summary for DHDH Gene

DHDH (Dihydrodiol Dehydrogenase) is a Protein Coding gene. Diseases associated with DHDH include Lung Cancer and Rubeosis Iridis. Among its related pathways are Porphyrin and chlorophyll metabolism and Drug metabolism - cytochrome P450. GO annotations related to this gene include oxidoreductase activity and trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHDH Gene

Genomics for DHDH Gene

Regulatory Elements for DHDH Gene

Enhancers for DHDH Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F048933 0.2 ENCODE 6.1 -0.1 -52 1.2 ATF1 PKNOX1 SP3 YY2 SP5 NFYC REST MBD2 SMARCA4 GLIS1 DHDH GC19P048929
GH19F048958 1.2 FANTOM5 ENCODE 5.3 +30.4 30391 10.2 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ENSG00000269321 NUP62 PRR12 TEAD2 PPP1R15A RUVBL2 KDELR1 PIH1D1 GRWD1 ENSG00000268157
GH19F048937 0.4 ENCODE 0.8 +4.2 4215 0.7 CTCF BCOR SUZ12 CEBPG ZNF48 ZNF316 GLIS2 ZNF366 POLR2A PATZ1 CPT1C DHDH GC19P048950
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DHDH on UCSC Golden Path with GeneCards custom track

Promoters for DHDH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for DHDH Gene

48,933,639 bp from pter
48,944,969 bp from pter
11,331 bases
Plus strand

Genomic View for DHDH Gene

Genes around DHDH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHDH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHDH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHDH Gene

Proteins for DHDH Gene

  • Protein details for DHDH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
    Protein Accession:

    Protein attributes for DHDH Gene

    334 amino acids
    Molecular mass:
    36382 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for DHDH Gene

Post-translational modifications for DHDH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHDH Gene

No data available for DME Specific Peptides for DHDH Gene

Domains & Families for DHDH Gene

Protein Domains for DHDH Gene

Suggested Antigen Peptide Sequences for DHDH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Gfo/Idh/MocA family.
  • Belongs to the Gfo/Idh/MocA family.
genes like me logo Genes that share domains with DHDH: view

No data available for Gene Families for DHDH Gene

Function for DHDH Gene

Molecular function for DHDH Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH.
UniProtKB/Swiss-Prot CatalyticActivity:
D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH.

Enzyme Numbers (IUBMB) for DHDH Gene

Gene Ontology (GO) - Molecular Function for DHDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008746 NAD(P)+ transhydrogenase activity TAS 10477285
GO:0009055 electron carrier activity TAS 10477285
GO:0016491 oxidoreductase activity IEA --
GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity IEA --
GO:0047837 D-xylose 1-dehydrogenase (NADP+) activity IBA --
genes like me logo Genes that share ontologies with DHDH: view
genes like me logo Genes that share phenotypes with DHDH: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DHDH

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHDH Gene

Localization for DHDH Gene

Subcellular locations from

Jensen Localization Image for DHDH Gene COMPARTMENTS Subcellular localization image for DHDH gene
Compartment Confidence
cytoskeleton 2
cytosol 2
extracellular 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DHDH Gene

Pathways & Interactions for DHDH Gene

genes like me logo Genes that share pathways with DHDH: view

Pathways by source for DHDH Gene

Gene Ontology (GO) - Biological Process for DHDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 10477285
GO:0042843 D-xylose catabolic process IBA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DHDH: view

No data available for SIGNOR curated interactions for DHDH Gene

Drugs & Compounds for DHDH Gene

(10) Drugs for DHDH Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Naphthalene-1,2-diol Experimental Pharma 0
Pyrocatechol Experimental Pharma 0

(26) Additional Compounds for DHDH Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
  • D-Xylonolactone
  • Xylonolactone
  • D-(+)-Xylose
  • D-Xylo-pentose
  • D-Xylose
  • Wood sugar
  • Xylo-pfan
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with DHDH: view

Transcripts for DHDH Gene

mRNA/cDNA for DHDH Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DHDH Gene

Dihydrodiol dehydrogenase (dimeric):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHDH Gene

No ASD Table

Relevant External Links for DHDH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHDH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DHDH Gene

mRNA differential expression in normal tissues according to GTEx for DHDH Gene

This gene is overexpressed in Kidney - Cortex (x9.7) and Small Intestine - Terminal Ileum (x6.1).

NURSA nuclear receptor signaling pathways regulating expression of DHDH Gene:


SOURCE GeneReport for Unigene cluster for DHDH Gene:


mRNA Expression by UniProt/SwissProt for DHDH Gene:

Tissue specificity: Small intestine.
genes like me logo Genes that share expression patterns with DHDH: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DHDH Gene

Orthologs for DHDH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHDH Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DHDH 34 35
  • 98.3 (n)
(Bos Taurus)
Mammalia DHDH 34 35
  • 86.99 (n)
(Canis familiaris)
Mammalia DHDH 34 35
  • 86.93 (n)
(Mus musculus)
Mammalia Dhdh 34 16 35
  • 78.58 (n)
(Rattus norvegicus)
Mammalia Dhdh 34
  • 78.51 (n)
(Monodelphis domestica)
Mammalia DHDH 35
  • 62 (a)
(Gallus gallus)
Aves DHDH 35
  • 34 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 51 (a)
-- 35
  • 51 (a)
-- 35
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dhdh 34
  • 58.86 (n)
(Danio rerio)
Actinopterygii zgc:101723 34
  • 58.68 (n)
DHDH (1 of 2) 35
  • 52 (a)
dhdhl 35
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3609 36 34 35
  • 53.6 (n)
CG3597 36 35
  • 38 (a)
CG13280 36 35
  • 35 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009945 34
  • 49.35 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G09670 34
  • 38.57 (n)
(Oryza sativa)
Liliopsida Os10g0403700 34
  • 46.69 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01704 34
  • 48.83 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC513.06c 34
  • 45.43 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
Species where no ortholog for DHDH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DHDH Gene

Gene Tree for DHDH (if available)
Gene Tree for DHDH (if available)

Paralogs for DHDH Gene

No data available for Paralogs for DHDH Gene

Variants for DHDH Gene

Sequence variations from dbSNP and Humsavar for DHDH Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs757900117 Uncertain significance 48,939,693(+) GCGTC(A/T)TGAAA nc-transcript-variant, reference, missense
rs10401800 -- 48,933,725(+) CCATG(A/C/G)CGCTG intron-variant, nc-transcript-variant, reference, missense
rs10402683 -- 48,934,108(+) CAACC(C/G)TGTGC intron-variant
rs10407186 -- 48,931,345(+) catga(A/G)ccact upstream-variant-2KB
rs10407419 -- 48,931,440(+) ttcaa(A/G)cattc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DHDH Gene

Variant ID Type Subtype PubMed ID
esv3644608 CNV loss 21293372
esv3644609 CNV loss 21293372
nsv518164 CNV loss 19592680
nsv521890 CNV gain 19592680
nsv833855 CNV loss 17160897
nsv833856 CNV loss 17160897
nsv833857 CNV loss 17160897
nsv9739 CNV gain+loss 18304495

Variation tolerance for DHDH Gene

Residual Variation Intolerance Score: 94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.70; 97.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHDH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHDH Gene

Disorders for DHDH Gene

MalaCards: The human disease database

(2) MalaCards diseases for DHDH Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, protection against
rubeosis iridis
- elite association - COSMIC cancer census association via MalaCards
Search DHDH in MalaCards View complete list of genes associated with diseases

Relevant External Links for DHDH

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DHDH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DHDH Gene

Publications for DHDH Gene

  1. Cloning and sequencing of the cDNA species for mammalian dimeric dihydrodiol dehydrogenases. (PMID: 10477285) Arimitsu E. … Hara A. (Biochem. J. 1999) 2 3 4 22 64
  2. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
  3. Overexpression of dihydrodiol dehydrogenase as a prognostic marker in resected gastric cancer patients. (PMID: 18600452) Chang H.C. … Fang H.Y. (Dig. Dis. Sci. 2009) 3 22 64
  4. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M. … Lan Q. (Environ. Mol. Mutagen. 2009) 3 46 64
  5. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PMID: 19625176) Hosgood H.D. … Lan Q. (Respir Med 2009) 3 46 64

Products for DHDH Gene

Sources for DHDH Gene

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