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Aliases for DHDH Gene

Aliases for DHDH Gene

  • Dihydrodiol Dehydrogenase (Dimeric) 2 3
  • D-Xylose-NADP Dehydrogenase 3 4
  • D-Xylose 1-Dehydrogenase 3 4
  • HUM2DD 3 4
  • 2DD 3 4
  • Dimeric Dihydrodiol Dehydrogenase 4
  • 3-Deoxyglucosone Reductase 3
  • EC 1.1.1.179 4
  • EC 1.3.1.20 4

External Ids for DHDH Gene

Previous GeneCards Identifiers for DHDH Gene

  • GC19P050095
  • GC19P049805
  • GC19P054112
  • GC19P054128
  • GC19P049436
  • GC19P045813

Summaries for DHDH Gene

Entrez Gene Summary for DHDH Gene

  • This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. [provided by RefSeq, Jul 2008]

GeneCards Summary for DHDH Gene

DHDH (Dihydrodiol Dehydrogenase (Dimeric)) is a Protein Coding gene. Diseases associated with DHDH include orchitis and lung cancer. Among its related pathways are Porphyrin and chlorophyll metabolism and Chemical carcinogenesis. GO annotations related to this gene include oxidoreductase activity and trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHDH Gene

Genomics for DHDH Gene

Regulatory Elements for DHDH Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DHDH Gene

Chromosome:
19
Start:
48,933,639 bp from pter
End:
48,944,969 bp from pter
Size:
11,331 bases
Orientation:
Plus strand

Genomic View for DHDH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHDH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHDH Gene

Proteins for DHDH Gene

  • Protein details for DHDH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQ10-DHDH_HUMAN
    Recommended name:
    Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
    Protein Accession:
    Q9UQ10

    Protein attributes for DHDH Gene

    Size:
    334 amino acids
    Molecular mass:
    36382 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for DHDH Gene

Proteomics data for DHDH Gene at MOPED

Post-translational modifications for DHDH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHDH Gene

Antibody Products

No data available for DME Specific Peptides for DHDH Gene

Domains & Families for DHDH Gene

Protein Domains for DHDH Gene

Suggested Antigen Peptide Sequences for DHDH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UQ10

UniProtKB/Swiss-Prot:

DHDH_HUMAN :
  • Belongs to the Gfo/Idh/MocA family.
Family:
  • Belongs to the Gfo/Idh/MocA family.
genes like me logo Genes that share domains with DHDH: view

No data available for Gene Families for DHDH Gene

Function for DHDH Gene

Molecular function for DHDH Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH
UniProtKB/Swiss-Prot CatalyticActivity:
D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH

Enzyme Numbers (IUBMB) for DHDH Gene

Gene Ontology (GO) - Molecular Function for DHDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008746 NAD(P)+ transhydrogenase activity TAS 10477285
GO:0009055 electron carrier activity TAS 10477285
GO:0016491 oxidoreductase activity --
GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity IEA --
GO:0047837 D-xylose 1-dehydrogenase (NADP+) activity IBA --
genes like me logo Genes that share ontologies with DHDH: view
genes like me logo Genes that share phenotypes with DHDH: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DHDH

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for DHDH Gene

Localization for DHDH Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHDH Gene COMPARTMENTS Subcellular localization image for DHDH gene
Compartment Confidence
cytoskeleton 2
nucleus 2
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DHDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA --
genes like me logo Genes that share ontologies with DHDH: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DHDH Gene

Pathways & Interactions for DHDH Gene

genes like me logo Genes that share pathways with DHDH: view

Pathways by source for DHDH Gene

Interacting Proteins for DHDH Gene

Gene Ontology (GO) - Biological Process for DHDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 10477285
GO:0042843 D-xylose catabolic process IBA --
GO:0055114 oxidation-reduction process IBA --
genes like me logo Genes that share ontologies with DHDH: view

No data available for SIGNOR curated interactions for DHDH Gene

Drugs & Compounds for DHDH Gene

(9) Drugs for DHDH Gene - From: HMDB and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Dicumarol Approved Pharma 0
Ethacrynic acid Approved Pharma 2
Haloperidol Approved Pharma Antagonist Antipsychotic drug 134
Indomethacin Approved, Investigational Pharma Inhibition, Inhibitor Cox inhibitor 97

(27) Additional Compounds for DHDH Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
1,2-Dihydronaphthalene-1,2-diol
D-Xylono-1,5-lactone
  • D-Xylonolactone
  • Xylonolactone
D-Xylose
  • D-(+)-Xylose
  • D-Xylo-pentose
  • D-Xylose
  • Wood sugar
  • Xylo-pfan
58-86-6
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with DHDH: view

Transcripts for DHDH Gene

mRNA/cDNA for DHDH Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DHDH Gene

Dihydrodiol dehydrogenase (dimeric):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DHDH

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHDH Gene

No ASD Table

Relevant External Links for DHDH Gene

GeneLoc Exon Structure for
DHDH
ECgene alternative splicing isoforms for
DHDH

Expression for DHDH Gene

mRNA expression in normal human tissues for DHDH Gene

mRNA differential expression in normal tissues according to GTEx for DHDH Gene

This gene is overexpressed in Kidney - Cortex (x9.7) and Small Intestine - Terminal Ileum (x6.1).

SOURCE GeneReport for Unigene cluster for DHDH Gene Hs.631555

mRNA Expression by UniProt/SwissProt for DHDH Gene

Q9UQ10-DHDH_HUMAN
Tissue specificity: Small intestine.
genes like me logo Genes that share expression patterns with DHDH: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DHDH Gene

Orthologs for DHDH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHDH Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DHDH 35
  • 86.99 (n)
  • 87.69 (a)
DHDH 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DHDH 35
  • 86.93 (n)
  • 86.53 (a)
DHDH 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dhdh 35
  • 78.58 (n)
  • 78.98 (a)
Dhdh 16
Dhdh 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DHDH 35
  • 98.3 (n)
  • 97 (a)
DHDH 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dhdh 35
  • 78.51 (n)
  • 77.71 (a)
oppossum
(Monodelphis domestica)
Mammalia DHDH 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves DHDH 36
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
-- 36
  • 47 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dhdh 35
  • 58.86 (n)
  • 53.75 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:101723 35
  • 58.68 (n)
  • 50 (a)
DHDH (1 of 2) 36
  • 52 (a)
OneToMany
dhdhl 36
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG13280 37
  • 35 (a)
CG3597 37
  • 38 (a)
CG3609 37
  • 42 (a)
CG3609 35
  • 53.6 (n)
  • 43.47 (a)
CG13280 36
  • 24 (a)
OneToMany
CG3597 36
  • 37 (a)
OneToMany
CG3609 36
  • 42 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009945 35
  • 49.35 (n)
  • 43.5 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G09670 35
  • 38.57 (n)
  • 26.03 (a)
rice
(Oryza sativa)
Liliopsida Os10g0403700 35
  • 46.69 (n)
  • 29.76 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01704 35
  • 48.83 (n)
  • 39.45 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC513.06c 35
  • 45.43 (n)
  • 37.54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for DHDH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DHDH Gene

ENSEMBL:
Gene Tree for DHDH (if available)
TreeFam:
Gene Tree for DHDH (if available)

Paralogs for DHDH Gene

No data available for Paralogs for DHDH Gene

Variants for DHDH Gene

Sequence variations from dbSNP and Humsavar for DHDH Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2270939 -- 48,939,676(-) ACGAC(A/G)GAAAT synonymous-codon, reference, nc-transcript-variant
rs2270940 -- 48,939,478(-) GCCTC(A/G)GAGGC reference, synonymous-codon, nc-transcript-variant
rs2270941 - 48,935,106(-) CCACG(C/T)TCGGG missense, reference, nc-transcript-variant
rs2270942 -- 48,934,744(-) TTGTG(C/T)GGGGA intron-variant, upstream-variant-2KB
rs3765148 - 48,944,456(-) TGCCC(C/T)GTTGT missense, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for DHDH Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv833855 CNV Loss 17160897
nsv833856 CNV Loss 17160897
nsv833857 CNV Loss 17160897
nsv518164 CNV Loss 19592680
nsv912248 CNV Loss 21882294
nsv521890 CNV Gain 19592680

Variation tolerance for DHDH Gene

Residual Variation Intolerance Score: 94.03% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.70; 97.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHDH Gene

HapMap Linkage Disequilibrium report
DHDH
Human Gene Mutation Database (HGMD)
DHDH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHDH Gene

Disorders for DHDH Gene

MalaCards: The human disease database

(2) MalaCards diseases for DHDH Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
orchitis
  • inflammation of testis
lung cancer
  • lung cancer, protection against
- elite association
Search DHDH in MalaCards View complete list of genes associated with diseases

Relevant External Links for DHDH

Genetic Association Database (GAD)
DHDH
Human Genome Epidemiology (HuGE) Navigator
DHDH
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHDH
genes like me logo Genes that share disorders with DHDH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DHDH Gene

Publications for DHDH Gene

  1. Cloning and sequencing of the cDNA species for mammalian dimeric dihydrodiol dehydrogenases. (PMID: 10477285) Arimitsu E. … Hara A. (Biochem. J. 1999) 2 23 67
  2. The CCAAT box binding transcription factor, nuclear factor-Y (NF-Y) regulates transcription of human aldo-keto reductase 1C1 (AKR1C1) gene. (PMID: 20338228) Pallai R. … Parekh H.K. (Gene 2010) 23 67
  3. A systematic review of genes involved in the inverse resistance relationship between cisplatin and paclitaxel chemotherapy: role of BRCA1. (PMID: 19442054) Stordal B. … Davey R. (Curr Cancer Drug Targets 2009) 23 67
  4. Overexpression of dihydrodiol dehydrogenase as a prognostic marker in resected gastric cancer patients. (PMID: 18600452) Chang H.C. … Fang H.Y. (Dig. Dis. Sci. 2009) 23 67
  5. Hepatocyte growth factor induces hypoxia-related interleukin-8 expression in lung adenocarcinoma cells. (PMID: 19184985) Chiang Y.Y. (Mol. Carcinog. 2009) 23 67

Products for DHDH Gene

Sources for DHDH Gene

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