Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DHDDS Gene

protein-coding   GIFtS: 58
GCID: GC01P026758

Dehydrodolichyl Diphosphate Synthase

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dehydrodolichyl Diphosphate Synthase1 2     RP592
HDS2 3 5     cis-IPTase2
Dedol-PP Synthase2 3     cis-isoprenyltransferase2
Epididymis Tissue Protein Li 189m2 3     Cis-Prenyl Transferase2
CIT2 3     Cis-IPTase3
CPT2     Cis-isoprenyltransferase3
DS2     EC 2.5.1.-3

External Ids:    HGNC: 206031   Entrez Gene: 799472   Ensembl: ENSG000001176827   OMIM: 6081725   UniProtKB: Q86SQ93   

Export aliases for DHDDS gene to outside databases

Previous GC identifers: GC01P025991 GC01P026363 GC01P026442 GC01P026631 GC01P025013


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DHDDS Gene:
The protein encoded by this gene catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of
dolichol, a glycosyl carrier lipid required for the biosynthesis of several classes of glycoproteins. Mutations
in this gene are associated with retinitis pigmentosa type 59. Alternatively spliced transcript variants encoding
different isoforms have been described for this gene. (provided by RefSeq, Aug 2011)

GeneCards Summary for DHDDS Gene: 
DHDDS (dehydrodolichyl diphosphate synthase) is a protein-coding gene. Diseases associated with DHDDS include dhdds-related retinitis pigmentosa, and pigmentary retinopathy, and among its related super-pathways are superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate). GO annotations related to this gene include protein binding and transferase activity, transferring alkyl or aryl (other than methyl) groups.

UniProtKB/Swiss-Prot: DHDDS_HUMAN, Q86SQ9
Function: Catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl
carrier-lipid required for the biosynthesis of several classes of glycoprotein

Gene Wiki entry for DHDDS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004610.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DHDDS gene promoter:
         Sp1   ARP-1   c-Myb   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDHDDS promoter sequence
   Search SABiosciences Chromatin IP Primers for DHDDS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHDDS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p35.3

DHDDS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHDDS gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P026758:  view genomic region     (about GC identifiers)

Start:
26,758,773 bp from pter      End:
26,797,797 bp from pter
Size:
39,025 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DHDDS_HUMAN, Q86SQ9 (See protein sequence)
Recommended Name: Dehydrodolichyl diphosphate synthase  
Size: 333 amino acids; 38657 Da
Subunit: Interacts with NUS1/NgBR, the interaction is required for efficient activity. Interacts with NPC2
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Note=colocalizes with calnexin
Secondary accessions: B7Z4B9 B7ZB20 D3DPK7 D3DPK8 D3DPK9 E9KL43 Q5T0A4 Q8NE90 Q9BTG5 Q9BTK3
Q9H905
Alternative splicing: 4 isoforms:  Q86SQ9-1   Q86SQ9-2   Q86SQ9-3   Q86SQ9-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DHDDS: NX_Q86SQ9

Explore proteomics data for DHDDS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86SQ9

  • DHDDS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DHDDS Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001230493.1  NP_001230494.1  NP_079163.2  NP_995583.1  

    ENSEMBL proteins: 
     ENSP00000403529   ENSP00000399177   ENSP00000434984   ENSP00000236342   ENSP00000434219  
     ENSP00000363300   ENSP00000353104   ENSP00000436119   ENSP00000436764   ENSP00000434185  
     ENSP00000431407   ENSP00000433976   ENSP00000405604   ENSP00000433491   ENSP00000397584  
     ENSP00000399781   ENSP00000393961  

    Human Recombinant Protein Products for DHDDS: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DHDDS
    OriGene Protein Over-expression Lysate for DHDDS
    OriGene MassSpec for DHDDS 
    OriGene Custom Protein Services for DHDDS
    GenScript Custom Purified and Recombinant Proteins Services for DHDDS
    Novus Biologicals DHDDS Protein
    Novus Biologicals DHDDS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DHDDS 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--

    DHDDS for ontologies           About GeneDecksing



    DHDDS Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DHDDS
    GenScript Custom Superior Antibodies Services for DHDDS
    Novus Biologicals DHDDS Antibodies
    Abcam antibodies for DHDDS
    Cloud-Clone Corp. Antibodies for DHDDS 
    Search ThermoFisher Antibodies for DHDDS
    LSBio Antibodies in human, mouse, rat for DHDDS 

    Assay Products for DHDDS: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DHDDS
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DHDDS
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DHDDS 
    Cloud-Clone Corp. CLIAs for DHDDS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001441 UPP_synth-like
     IPR018520 UPP_synth-like_CS

    Graphical View of Domain Structure for InterPro Entry Q86SQ9

    ProtoNet protein and cluster: Q86SQ9

    1 Blocks protein domain: IPB001441 Di-trans-poly-cis-decaprenylcistransferase

    UniProtKB/Swiss-Prot: DHDDS_HUMAN, Q86SQ9
    Similarity: Belongs to the UPP synthase family


    DHDDS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DHDDS_HUMAN, Q86SQ9
    Function: Catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl
    carrier-lipid required for the biosynthesis of several classes of glycoprotein

         Enzyme Number (IUBMB): EC 2.5.1.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15110773
    GO:0016765transferase activity, transferring alkyl or aryl (other than methyl) groups IEA--
         
    DHDDS for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DHDDS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DHDDS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DHDDS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DHDDS 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DHDDS
    8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate DHDDS (see all 65):
    hsa-miR-100* hsa-miR-4254 hsa-miR-3194-5p hsa-miR-15a hsa-miR-605 hsa-miR-10b* hsa-miR-3622b-3p hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmidDHDDS 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DHDDS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DHDDS

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DHDDS
    Sirion Biotech Customized adenovirus for overexpression of DHDDS

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for DHDDS (see all 13)
    OriGene ORF clones in mouse, rat for DHDDS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DHDDS (NM_024887)
    Sino Biological Human cDNA Clone for DHDDS
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHDDS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHDDS
    Sirion Biotech Customized lentivirus for stable overexpression of DHDDS 
                         Customized lentivirus expression plasmids for stable overexpression of DHDDS 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DHDDS
    Search LifeMap BioReagents cell lines for DHDDS
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHDDS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DHDDS About                                                                                                See pathways by source

    SuperPathContained pathways About
    1superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
    Terpenoid backbone biosynthesis0.55
    2dolichol and dolichyl phosphate biosynthesis
    dolichol and dolichyl phosphate biosynthesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for DHDDS
        dolichol and dolichyl phosphate biosynthesis



    1         Kegg Pathway  (Kegg details for DHDDS):
        Terpenoid backbone biosynthesis

    UniProtKB/Swiss-Prot: DHDDS_HUMAN, Q86SQ9
    Pathway: Protein modification; protein glycosylation


    DHDDS for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DHDDS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/44 Interacting proteins for DHDDS (Q86SQ93 ENSP000003531044) via UniProtKB, MINT, STRING, and/or I2D (see all 44)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGPAT1Q999433I2D: score=4 
    ENSG00000206324Q999433I2D: score=4 
    ENSG00000226467Q999433I2D: score=4 
    ENSG00000227642Q999433I2D: score=4 
    ENSG00000228892Q999433I2D: score=4 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation IEA--

    DHDDS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DHDDS

    1 HMDB Compound for DHDDS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Undecaprenyl diphosphateDiphosphoric acid mono(3,7,11,15,19,23,27,31,35,39,43-undecamethyl-2,6,10,14,18,22,26,30,34,38,42-tetratetracontaundecaenyl) ester (see all 8)23-13-2--

    Search CenterWatch for drugs/clinical trials and news about DHDDS

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DHDDS gene (4 alternative transcripts): 
    NM_001243564.1  NM_001243565.1  NM_024887.3  NM_205861.2  

    Unigene Cluster for DHDDS:

    Dehydrodolichyl diphosphate synthase
    Hs.369385  [show with all ESTs]
    Unigene Representative Sequence: BX648507
    18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000434391(uc001bmk.3 uc001bml.3 uc001bmn.3 uc010ofd.2 uc001bmm.3)
    ENST00000427245 ENST00000527611 ENST00000374186 ENST00000525682 ENST00000236342
    ENST00000526219 ENST00000374185 ENST00000487944 ENST00000360009 ENST00000533087
    ENST00000531312 ENST00000525165 ENST00000525326 ENST00000525546 ENST00000528557
    ENST00000526278 ENST00000436153
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DHDDS
    8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate DHDDS (see all 65):
    hsa-miR-100* hsa-miR-4254 hsa-miR-3194-5p hsa-miR-15a hsa-miR-605 hsa-miR-10b* hsa-miR-3622b-3p hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmidDHDDS 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DHDDS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DHDDS
    Clone
    Products:
         
    OriGene clones in human, mouse for DHDDS (see all 13)
    OriGene ORF clones in mouse, rat for DHDDS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DHDDS (NM_024887)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHDDS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHDDS
    Sirion Biotech Customized lentivirus for stable overexpression of DHDDS 
                         Customized lentivirus expression plasmids for stable overexpression of DHDDS 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DHDDS
    OriGene qSTAR qPCR primer pairs in human, mouse for DHDDS
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DHDDS
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DHDDS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHDDS

    Additional mRNA sequence: 

    AB090852.1 AK023164.1 AK297134.1 AK308187.1 AK316485.1 BC003643.2 BC004117.2 BC034152.1 
    BX648507.1 GU727641.1 

    14 DOTS entries:

    DT.99948354  DT.91758707  DT.97764546  DT.440354  DT.91758706  DT.95069950  DT.100710474  DT.97826366 
    DT.91758705  DT.97793209  DT.121445892  DT.121445909  DT.40264123  DT.40305720 

    24/181 AceView cDNA sequences (see all 181):

    BQ438280 CA447703 BF684863 CA427538 AI871602 BF062692 AA280902 AW630743 
    BM352399 AA586951 BQ184436 BM687199 BC003643 BC004117 CD366547 BQ641323 
    NM_024887 BG261190 NM_205861 BX490547 BF437274 BQ189030 AL701938 AI810984 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for DHDDS (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d
    SP1:                          -     -                 -     -                       -                       -                                             
    SP2:                          -     -                 -     -     -                 -     -     -           -                                             
    SP3:                                                  -     -     -                 -                       -                                             
    SP4:                                                  -     -     -                 -                       -                                             
    SP5:                                                  -     -     -                 -                                                                     


    ECgene alternative splicing isoforms for DHDDS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DHDDS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCCAGAAT
    DHDDS Expression
    About this image


    See DHDDS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DHDDS

    SOURCE GeneReport for Unigene cluster: Hs.369385

    UniProtKB/Swiss-Prot: DHDDS_HUMAN, Q86SQ9
    Tissue specificity: Expressed at high levels in testis and kidney. Expressed in epididymis (at protein level).
    Slightly expressed in heart, spleen and thymus

        SABiosciences Custom PCR Arrays for DHDDS
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DHDDS
    OriGene qSTAR qPCR primer pairs in human, mouse for DHDDS
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DHDDS
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DHDDS
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHDDS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHDDS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DHDDS gene from 10/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dhdds1 , 5 dehydrodolichyl diphosphate synthase1, 5 88.19(n)1
    92.49(a)1
      4 (66.47 cM)5
    674221  NM_026144.41  NP_080420.21 
     1339690285 
    chicken
    (Gallus gallus)
    Aves DHDDS1 dehydrodolichyl diphosphate synthase 75.98(n)
    81.68(a)
      419543  XM_417694.2  XP_417694.2 
    lizard
    (Anolis carolinensis)
    Reptilia DHDDS6
    Uncharacterized protein
    75(a)
    1 ↔ 1
    GL343480.1(629321-637004)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3986262 hypothetical protein LOC398626 75.02(n)    BC054312.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd56c062 Transcribed sequence with moderate similarity to protein refNP_079163.1 (H.sapiens) hypothetical protein FLJ13102 [Homo sapiens] less 75.85(n)    CD758453.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG107781 CG10778 55.18(n)
    50.68(a)
      31708  NM_132197.2  NP_572425.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T01G1.41 Protein T01G1.4 51.9(n)
    45.53(a)
      266904  NM_001028180.3  NP_001023351.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RER2(YBR002C)4
    RER21
    Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting less4
    Rer2p1
    48.34(n)1
    44.16(a)1
      2(242568-241708)4
    8522871, 4  NP_009556.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G175701 dehydrodolichyl diphosphate synthase 6 46.87(n)
    39.46(a)
      816264  NM_127311.4  NP_565420.1 
    rice
    (Oryza sativa)
    Liliopsida Os.74782 Oryza sativa (japonica cultivar-group) cDNA cloneJ033084O09, full insert sequence less 80.17(n)    AK069186.1 


    ENSEMBL Gene Tree for DHDDS (if available)
    TreeFam Gene Tree for DHDDS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/762 SNPs in DHDDS are shown (see all 762)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0653564
    Retinitis pigmentosa 59 (RP59)4--see VAR_0653562 K E mis40--------
    rs172619151,2
    C,F,H--25011202(+) AATCCT/CCAAGC 4 -- us2k121Minor allele frequency- C:0.14NA EA NS 2432
    rs1917886841,2
    --25011226(+) AGTAAA/GGGTAA 4 -- us2k10--------
    rs1839335941,2
    --25011632(+) ACATAA/CTACTA 4 -- us2k10--------
    rs1503787261,2
    --25011733(+) GCAGGC/TAGATA 4 -- us2k10--------
    rs1382299071,2
    C--25011740(+) GATAAC/TGAGGT 4 -- us2k10--------
    rs94385471,2
    C,F--25011833(+) GCGCCC/TGTAGT 4 -- us2k15Minor allele frequency- T:0.33NA WA CSA 9
    rs94385481,2
    C,F,H--25011894(+) GGAGGT/CTGCAG 4 -- us2k16Minor allele frequency- C:0.17NA WA 12
    rs758254511,2
    C,F--25012022(+) ATTTTT/CTCCTC 4 -- us2k12Minor allele frequency- C:0.08WA 120
    rs1390164181,2
    C--25012359(+) ACAGGC/TGCCCG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for DHDDS (26758773 - 26797797 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DHDDS:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv202n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): DHDDS
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing DHDDS
    DNA2.0 Custom Variant and Variant Library Synthesis for DHDDS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608172    OMIM disorders: --

    UniProtKB/Swiss-Prot: DHDDS_HUMAN, Q86SQ9
  • Retinitis pigmentosa 59 (RP59) [MIM:613861]: A retinal dystrophy belonging to the group of pigmentary
    retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination
    and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically
    have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose
    their far peripheral visual field and eventually central vision as well. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 11 diseases for DHDDS:    About MalaCards
    dhdds-related retinitis pigmentosa    pigmentary retinopathy    bullous pemphigoid    rhyns syndrome
    retinitis pigmentosa    epididymitis    retinitis    blindness
    dementia    pneumonia    tuberculosis


    DHDDS for disorders           About GeneDecksing

    Genetic Association Database (GAD): DHDDS
    Human Genome Epidemiology (HuGE) Navigator: DHDDS (1 document)

    Export disorders for DHDDS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DHDDS gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with DHDDS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of human dehydrodolichyl diphosphate synthase gene. (PubMed id 12591616)1, 2, 3 Endo S.... Koyama T. (2003)
    2. Whole-exome sequencing links a variant in DHDDS to retinitis pigmentosa. (PubMed id 21295283)1, 2 Zuchner S.... Pericak-Vance M.A. (2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PubMed id 20736409)1, 2 Li J.... Liu Y. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Identification and characterization of a cDNA encoding a long-chain cis-isoprenyltranferase involved in dolichyl monophosphate biosynthesis in the ER of brain cells. (PubMed id 14652022)1, 2 Shridas P....Waechter C.J. (2003)
    8. In vivo interaction between the human dehydrodolichyl diphosphate synthase and the Niemann-Pick C2 protein revealed by a yeast two-hybrid system. (PubMed id 15110773)1, 9 Kharel Y....Koyama T. (2004)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. Nogo-B receptor is necessary for cellular dolichol bi osynthesis and protein N-glycosylation. (PubMed id 21572394)2 Harrison K.D....Sessa W.C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79947 HGNC: 20603 AceView: DHDDS Ensembl:ENSG00000117682 euGenes: HUgn79947
    ECgene: DHDDS Kegg: 79947 H-InvDB: DHDDS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DHDDS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DHDDS gene:
    Search GeneIP for patents involving DHDDS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DHDDS  
     OriGene qPCR primer pairs and template standards for DHDDS   OriGene Protein Over-expression Lysate for DHDDS  
     OriGene MassSpec something-or-other for DHDDS   OriGene clones in human, mouse for DHDDS  
     OriGene qSTAR qPCR primer pairs in human, mouse for DHDDS   OriGene Purified Protein for DHDDS  
     OriGene ORF clones in mouse, rat for DHDDS   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DHDDS   OriGene Custom Protein Services for DHDDS  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DHDDS
     QIAGEN SeqTarget long-range PCR primers for resequencing DHDDS
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHDDS
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DHDDS
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHDDS
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DHDDS
     GenScript Custom Purified and Recombinant Proteins Services for DHDDS GenScript cDNA clones with any tag delivered in your preferred vector for DHDDS
     GenScript Custom Assay Services for DHDDS GenScript Custom Superior Antibodies Services for DHDDS
     GenScript Custom overexpressing Cell Line Services for DHDDS CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in DHDDS promoter
     Search Chromatin IP Primers for DHDDS
     RT2 qPCR Primer Assay in human, mouse, rat DHDDS
     GNC Network for DHDDS
     SABiosciences Custom PCR Arrays for DHDDS
     Search Tocris compounds for DHDDS
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for DHDDS
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     DHDDS antibodies
     DHDDS proteins
     DHDDS lysates
     Antibodies for DHDDS
     See all of Abcam's Antibodies, Kits and Proteins for DHDDS
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for DHDDS
     Antibodies for DHDDS
     ELISAs for DHDDS
     CLIAs for DHDDS
     Search LifeMap BioReagents cell lines for DHDDS
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHDDS
     SwitchGear 3'UTR luciferase reporter plasmids for DHDDS
     SwitchGear Promoter luciferase reporter plasmids for DHDDS
     Search ThermoFisher Antibodies for DHDDS
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHDDS
     inGenious Targeting Laboratory - Custom generated mouse model solutions for DHDDS
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DHDDS
    Customized:
     lentivirus for stable overexpression of DHDDS
     lentivirus expression plasmids for stable overexpression of DHDDS
     adenovirus for overexpression of DHDDS
     LSBio Antibodies in human, mouse, rat for DHDDS
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DHDDS gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4