Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DHCR7 Gene

protein-coding   GIFtS: 71
GCID: GC11M071145

7-Dehydrocholesterol Reductase

(Previous name: Smith-Lemli-Opitz syndrome)
(Previous symbol: SLOS)
  See DHCR7-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
7-Dehydrocholesterol Reductase1 2     Delta-7-Dehydrocholesterol Reductase2
SLOS1 2 5     Sterol Delta-7-Reductase2
Putative Sterol Reductase SR-22 3     D7SR3
7-DHC Reductase2 3     Sterol Delta(7)-Reductase3
EC 1.3.1.213 8     EC 1.3.18
Smith-Lemli-Opitz Syndrome1     

External Ids:    HGNC: 28601   Entrez Gene: 17172   Ensembl: ENSG000001728937   OMIM: 6028585   UniProtKB: Q9UBM73   

Export aliases for DHCR7 gene to outside databases

Previous GC identifers: GC11M073477 GC11M072685 GC11M071368 GC11M070871 GC11M070823 GC11M067439


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DHCR7 Gene:
This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the
conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane
protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause
Smith-Lemli-Opitz syndrome (SLOS); a syndrome that is metabolically characterized by reduced serum cholesterol
levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation,
facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal
physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple
transcript variants that encode the same protein.(provided by RefSeq, Aug 2009)

GeneCards Summary for DHCR7 Gene:
DHCR7 (7-dehydrocholesterol reductase) is a protein-coding gene. Diseases associated with DHCR7 include smith-lemli-opitz syndrome, and syndactyly. GO annotations related to this gene include 7-dehydrocholesterol reductase activity. An important paralog of this gene is LBR.

UniProtKB/Swiss-Prot: DHCR7_HUMAN, Q9UBM7
Function: Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC)

summary for DHCR7 Gene:
Delta7-Dehydrocholesterol reductase (DHCR) is a membrane-bound enzyme that catalyzes the final step of
cholesterol biosynthesis (the reduction of the C7-8 double bond in 7-dehydrocholesterol to form
cholesterol), using NADPH as a cofactor. Cholesterol is a vital component in biological membranes and in
myelin and is necessary for the synthesis of steroid hormones and bile acids. DHCR is ubiquitously expressed
and its highest concentrations are found in the liver and brain. Autosomal recessive mutations in the DHCR7
gene have been linked to Smith-Lemli-Opitz syndrome, an inherited disease causing multiple congenital
abnormalities linked to defects in cholesterol biosynthesis. The human gene encoding this enzyme is
localized to 11q12-13.

Gene Wiki entry for DHCR7 (7-Dehydrocholesterol reductase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DHCR7 gene promoter:
         SRF   NF-1   NF-1/L   GATA-3   SRF (504 AA)   GATA-1   GATA-2   YY1   HOXA5   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DHCR7 promoter sequence
   Search Chromatin IP Primers for DHCR7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DHCR7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.4

DHCR7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHCR7 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M071145:  view genomic region     (about GC identifiers)

Start:
71,139,239 bp from pter      End:
71,163,914 bp from pter
Size:
24,676 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DHCR7_HUMAN, Q9UBM7 (See protein sequence)
Recommended Name: 7-dehydrocholesterol reductase  
Size: 475 amino acids; 54489 Da
Secondary accessions: B2R6Z2 O60492 O60717

Explore the universe of human proteins at neXtProt for DHCR7: NX_Q9UBM7

Explore proteomics data for DHCR7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys13, Lys88
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DHCR7 (Q9UBM7) (see all 11)
     HLLPYFY  MGIEFNP  FIMACDQY  DNWIPLLWC 


    See DHCR7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001157289.1  NP_001351.2  

    ENSEMBL proteins: 
     ENSP00000432256   ENSP00000384739   ENSP00000347717   ENSP00000435011   ENSP00000435956  
     ENSP00000435047   ENSP00000435668   ENSP00000435707   ENSP00000432589   ENSP00000435058  
     ENSP00000436007  
    Reactome Protein details: Q9UBM7

    DHCR7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for DHCR7
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DHCR7
    GenScript Custom Purified and Recombinant Proteins Services for DHCR7
    Novus Biologicals DHCR7 Protein
    Novus Biologicals DHCR7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DHCR7

     
    Search eBioscience for Proteins for DHCR7 

     
    antibodies-online proteins for DHCR7 (2 products) 

     
    antibodies-online peptides for DHCR7

    DHCR7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DHCR7
    Novus Biologicals DHCR7 Antibodies
    Abcam antibodies for DHCR7
    Cloud-Clone Corp. Antibodies for DHCR7
    Search ThermoFisher Antibodies for DHCR7
    antibodies-online antibodies for DHCR7 (23 products) 

    DHCR7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DHCR7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DHCR7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DHCR7
    Cloud-Clone Corp. CLIAs for DHCR7
    Search eBioscience for ELISAs for DHCR7 
    antibodies-online kits for DHCR7 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR001171 Ergosterol_biosynth_ERG4_ERG24
     IPR018083 Sterol_reductase_CS

    Graphical View of Domain Structure for InterPro Entry Q9UBM7

    ProtoNet protein and cluster: Q9UBM7

    2 Blocks protein domains:
    IPB001171 ERG4/ERG24 ergosterol biosynthesis protein
    IPB011024 Gamma-crystallin related


    UniProtKB/Swiss-Prot: DHCR7_HUMAN, Q9UBM7
    Similarity: Belongs to the ERG4/ERG24 family


    Find genes that share domains with DHCR7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DHCR7_HUMAN, Q9UBM7
    Function: Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC)
    Catalytic activity: Cholesterol + NADP(+) = cholesta-5,7-dien-3-beta-ol + NADPH

         Genatlas biochemistry entry for DHCR7:
    delta 7-dehydrocholesterol reductase,located in the endoplasmic reticulum and continuous outer nuclear
    membrane,ubiquitously expressed,most abundant in adrenals,liver,testis,brain,LBR superfamily,catalyzing the
    ultimate step of cholesterol biosynthesis,deficient in SLOS

         Enzyme Numbers (IUBMB): EC 1.3.1.211 2 EC 1.3.12

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016628oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor ----
    GO:00475987-dehydrocholesterol reductase activity IDA9465114
         
    Find genes that share ontologies with DHCR7           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DHCR7:
     Decreased viability  Upregulation of Wnt/beta-caten 

         13 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Dhcr7):
     behavior/neurological  cardiovascular system  craniofacial  digestive/alimentary  growth/size/body 
     homeostasis/metabolism  limbs/digits/tail  liver/biliary system  mortality/aging  muscle 
     nervous system  renal/urinary system  respiratory system 

    Find genes that share phenotypes with DHCR7           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for DHCR7: Dhcr7tm1Gst Dhcr7tm1Fdp

       genOway: Develop your customized and physiologically relevant rodent model for DHCR7

    miRNA
    Products:
        
    miRTarBase miRNAs that target DHCR7:
    hsa-mir-335-5p (MIRT016982), hsa-mir-425-5p (MIRT016653), hsa-mir-34a-5p (MIRT025254), hsa-mir-1260b (MIRT052760)

    Block miRNA regulation of human, mouse, rat DHCR7 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate DHCR7
    SwitchGear 3'UTR luciferase reporter plasmidDHCR7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DHCR7
    Predesigned siRNA for gene silencing in human, mouse, rat DHCR7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DHCR7

    Clone
    Products:
         
    OriGene clones in human, mouse for DHCR7 (see all 11)
    OriGene ORF clones in mouse, rat for DHCR7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DHCR7 (NM_001360)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHCR7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHCR7

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DHCR7
    Browse ESI BIO Cell Lines and PureStem Progenitors for DHCR7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHCR7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DHCR7_HUMAN, Q9UBM7: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus5
    plasma membrane3

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005640nuclear outer membrane IDA9878250
    GO:0005783endoplasmic reticulum IDA9878250
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with DHCR7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for DHCR7 About    
    See pathways by source

    SuperPathContained pathways About
    1superpathway of cholesterol biosynthesis
    superpathway of cholesterol biosynthesis0.85
    Steroid biosynthesis0.57
    Cholesterol biosynthesis0.85
    cholesterol biosynthesis I0.00
    Cholesterol biosynthesis0.62
    cholesterol biosynthesis III (via desmosterol)0.00
    cholesterol biosynthesis II (via 24,25-dihydrolanosterol)0.59
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    3Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)0.75
    Activation of Gene Expression by SREBP (SREBF)0.75


    Find genes that share SuperPaths with DHCR7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 BioSystems Pathways for DHCR7
        Cholesterol biosynthesis
    cholesterol biosynthesis I
    superpathway of cholesterol biosynthesis
    cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
    cholesterol biosynthesis III (via desmosterol)

    2 Reactome Pathways for DHCR7
        Cholesterol biosynthesis
    Activation of gene expression by SREBF (SREBP)


    2 Kegg Pathways  (Kegg details for DHCR7):
        Steroid biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: DHCR7_HUMAN, Q9UBM7
    Pathway: Steroid biosynthesis; cholesterol biosynthesis

        Pathway & Disease-focused RT2 Profiler PCR Array including DHCR7: 

              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DHCR7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DHCR7 (Q9UBM72, 3 ENSP000003477174) via UniProtKB, MINT, STRING, and/or I2D (see all 183)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG482, 3, ENSP000003448184MINT-6489355 I2D: score=1 STRING: ENSP00000344818
    AGO2Q9UKV82, ENSP000002205924MINT-6489217 MINT-6489355 STRING: ENSP00000220592
    FADS1O604273, ENSP000003222294I2D: score=2 STRING: ENSP00000322229
    NDNQ996083, ENSP000003326434I2D: score=2 STRING: ENSP00000332643
    ACP6Q9NPH03, ENSP000003582414I2D: score=1 STRING: ENSP00000358241
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001568blood vessel development IEA--
    GO:0006695cholesterol biosynthetic process TAS--
    GO:0009791post-embryonic development IEA--
    GO:0016126sterol biosynthetic process ----
    GO:0030154cell differentiation IEA--

    Find genes that share ontologies with DHCR7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for DHCR7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AY 9944 dihydrochlorideInhibitor of Hedgehog (Hh) signaling. Inhibits delta7-dehydrocholesterol reductase[366-93-8]

    10 HMDB Compounds for DHCR7    About this table
    CompoundSynonyms CAS #PubMed Ids
    7-Dehydrocholesterol(-)-7-dehydrocholesterol (see all 26)434-16-218285838
    24-Methylenecholesterol(3b)-Ergosta-5,24(28)-dien-3-ol (see all 8)474-63-5--
    5-Dehydroavenasterol ----
    5-DehydroepisterolErgosta-5,7,24(28)-trien-3beta-ol (see all 2)23582-83-4--
    AvenasterolIsofucosterol (see all 10)481-14-1--
    Cholesterol(+)-ent-Cholesterol (see all 39)57-88-5--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--

    1 DrugBank Compound for DHCR7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for DHCR7 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    7-dehydrocholesterol 98.3 159 9683613 (4), 16814115 (3), 9634533 (3), 20014133 (3) (see all 73)
    8-dehydrocholesterol 93.4 7 19406241 (1), 18249054 (1), 12949967 (1), 11352988 (1)
    3beta-hydroxysterol 92.3 6 16392899 (1), 11001807 (1), 11562938 (1), 16446309 (1) (see all 6)
    ay9944 84.6 7 8987154 (2), 9358606 (2), 16814115 (1)
    sterol 80.2 22 9634533 (4), 11001806 (2), 19940018 (2), 9683613 (1) (see all 10)
    cholesterol 76 135 17408495 (4), 20014133 (3), 16687448 (3), 18951487 (2) (see all 66)
    desmosterol 59.4 1 16207203 (1)
    squalene 53.1 8 18951487 (2), 15143536 (1)
    ergosterol 43.9 2 10719329 (1), 15464432 (1)
    simvastatin 42.8 3 15896653 (2), 19365639 (1)



    Find genes that share compounds with DHCR7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DHCR7 gene (2 alternative transcripts): 
    NM_001163817.1  NM_001360.2  

    Unigene Cluster for DHCR7:

    7-dehydrocholesterol reductase
    Hs.503134  [show with all ESTs]
    Unigene Representative Sequence: NM_001360
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000534795 ENST00000407721 ENST00000355527(uc001oqk.3 uc001oql.3)
    ENST00000533800 ENST00000525137 ENST00000527316 ENST00000534701 ENST00000526780
    ENST00000525346 ENST00000531364 ENST00000529990 ENST00000527452
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DHCR7 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate DHCR7
    SwitchGear 3'UTR luciferase reporter plasmidDHCR7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DHCR7
    Predesigned siRNA for gene silencing in human, mouse, rat DHCR7
    Clone
    Products:
         
    OriGene clones in human, mouse for DHCR7 (see all 11)
    OriGene ORF clones in mouse, rat for DHCR7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DHCR7 (NM_001360)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHCR7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHCR7
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DHCR7
    OriGene qSTAR qPCR primer pairs in human, mouse for DHCR7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DHCR7
      QuantiTect SYBR Green Assays in human, mouse, rat DHCR7
      QuantiFast Probe-based Assays in human, mouse, rat DHCR7

    Additional mRNA sequence: 

    AF034544.1 AF062481.1 AF067127.1 AF096305.1 AK289497.1 AK303881.1 AK309625.1 AK312775.1 
    BC000054.2 

    19 DOTS entries:

    DT.100647914  DT.418224  DT.100647904  DT.95326177  DT.100647915  DT.120742723  DT.100671595  DT.120742731 
    DT.91758253  DT.95181639  DT.95357168  DT.100033172  DT.100647913  DT.120742718  DT.40108063  DT.95290620 
    DT.95357178  DT.100837843  DT.95357166 

    440 AceView cDNA sequences (see top 24):

    AL044893 BM560287 BI835977 CR605911 AA343352 BG386167 AW249784 CD672136 
    CA454504 AA364447 BU846251 AU125589 AA861245 AA282516 BE799908 BU684875 
    AA070075 BU931469 BU848891 CR609879 AI610807 AI192049 AA834440 AL118630 
    BU632366 BM773173 CR597288 AI521555 BI819438 BM548686 AI682081 AW806469 
    BM909778 BU850080 AU132882 AA743498 AV702785 AA678013 BI756953 AI685468 
    AL547161 CD672847 CA454869 BM917982 AI878957 BQ888385 BQ935848 AL119180 
    AI969800 AU130637 BM547291 BQ718966 BQ882354 BM839481 N57922 BX091206 
    BP357137 AA351881 BE617055 BM742975 BQ054698 H69324 BI753515 AL532112 
    BM821964 AW580431 AU131409 BE621211 AI288677 BQ687888 AW955945 BI766210 
    AW235924 AA300253 AW237004 BU621139 AA399209 AF067127 AA737995 BG177941 
    CA446715 BQ063914 BI752950 BM925715 BM747310 BU147122 BP351289 AA443525 
    BE743234 BQ066258 BQ061656 AW006923 AU132051 AA599455 AL557740 BQ045301 
    AU279983 CB134473 BI836249 BP361940 AI689711 BF982370 BQ957187 AA398257 
    AU131837 BF970752 BU628238 BI522679 BM047973 BQ445837 AL520021 BE393891 
    BU733448 BM045901 AU131563 AL532869 BM725069 BX352382 BP360511 BX420719 
    BX383615 AA970494 AU130542 AU124614 BQ065944 AL532817 AU120973 BU859819 
    BM048543 AA599359 AI435048 BQ581603 AI669821 CD369586 BM742248 BF762217 
    AI913455 AU125910 BG400867 BQ055786 BI821203 BI762302 BI913743 AL530229 
    AI400394 BM827552 BQ061658 BG763442 CB156025 AL550863 BU733438 BQ061864 
    BU855933 BM472830 BG323886 CA487686 CA455217 BM468769 BG748965 AW806754 
    BG749274 BM773303 BM012656 BP363730 BI831089 BI868736 BG024243 BM712273 
    BU858183 AI888720 AI653428 BQ691492 BI757922 BG698128 CA488430 AA775663 
    BE740791 AA429396 AI183635 BM981437 BG764819 AA704505 AI359110 BM042168 
    BQ433352 AU133292 BF088156 BF978932 BV179838 AU131534 AU131193 BE076162 
    BQ678981 BI826060 W05001 BQ679622 BX384827 AI190356 BQ062778 AF096305 
    BI759064 BE378962 AA357609 BU944629 AI651625 AU131862 AI651619 BE293240 
    BX462277 R50345 BI826891 BM764545 BX496260 BQ686764 BE898909 BQ061700 
    BP351181 AF062481 BQ069707 BU542583 BM998500 BM927332 CA454979 AI200950 
    BU179087 AF034544 AA336925 AI652764 BQ896713 H59653 AA282412 BU734264 
    AL526917 AU153407 BE047742 BQ689803 AW027451 BX385237 BM046874 BI819737 
    BQ070244 CD611360 BM797915 BQ721193 BQ682246 AU131531 BF593713 AL556661 
    BE261725 BM716312 BG910322 BM795204 BC000054 BE390816 AU125061 AA313400 
    AL574612 BG740204 BQ681314 NM_001360 BX435841 CA454891 AI567453 AA302341 
    BG253318 BM745004 AI203117 BI767334 BU627495 BI818896 AI026700 AU132038 
    AU125047 BI196559 BU741969 BM548502 BI757353 AA503528 AA627585 BP349412 
    BU542078 AU153527 AW150953 BX452612 BE314716 BQ691552 AA464773 BI199100 
    AA514515 BI916544 CF132489 AI690960 AA160364 F08418 BQ645826 BU155503 
    AA017353 BX330927 BI915276 BE313736 AA781972 BF034259 BF038048 AL561845 
    AW085492 AU124763 H09665 AA292187 R50008 BE502142 H97015 BP373702 
    BP350989 BX364742 AA683516 BM752550 BE742901 AW806574 AI042444 BE312456 
    BI195715 BF824929 R16081 W87479 BE395197 BX458169 AI285221 BM798482 
    AU154328 BQ222440 AI903797 BP360838 BU731973 CA489871 AI022413 BE909071 
    BE260592 BU737740 AA328114 BE537695 BU150016 AU153503 AW248123 BP383618 
    BP429401 BX400606 AU153257 H59613 AL582191 BF361700 AW068650 N70359 
    BE549329 AA188832 N68101 AA188795 BX453745 BF800485 AW939298 BM753430 
    BI199096 AU153285 AL527076 BF092024 AU146897 AI034087 W87472 AA923356 
    AU152551 AL578871 AA070844 BG164655 AU152984 BU838690 AI370888 AU153260 
    BU677146 AA464182 AA017586 BI197569 BG391556 AU152459 H69421 BE076148 
    H04989 AU149475 AL572219 AU148438 AU153668 BQ581929 AU148792 BX364741 
    AW295514 T47284 AL560842 AW997153 BM983074 W87507 R61101 BE393459 
    AU098828 AA160454 BQ299950 BQ065902 AU153147 H04990 BX334102 AU148801 
    R88150 AA471295 BI915936 AU154658 CD611361 BM042736 BX452611 BG255397 
    BF030167 BI826599 H09710 AL564280 R87706 BF088189 BX438503 AA566025 
    T67482 BE880588 BF850378 T67599 BX362657 BF817269 CA489529 BF760961 
    BQ331149 BI832298 R61824 BQ677782 BG169185 BQ642967 BX387563 BM544155 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DHCR7 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b
    SP1:                          -     -     -                             -                       -                                         -               
    SP2:                                -     -                             -                       -                                         -               
    SP3:                                -     -                             -                       -                                                         
    SP4:                                -     -                             -     -                 -                                                         
    SP5:                                -     -                             -                                                                                 


    ECgene alternative splicing isoforms for DHCR7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DHCR7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCGTTTCCTT
    DHCR7 Expression
    About this image


    DHCR7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    DHCR7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DHCR7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.503134

    UniProtKB/Swiss-Prot: DHCR7_HUMAN, Q9UBM7
    Tissue specificity: Most abundant in adrenal gland, liver, testis, and brain

        Pathway & Disease-focused RT2 Profiler PCR Array including DHCR7: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DHCR7
    OriGene qSTAR qPCR primer pairs in human, mouse for DHCR7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DHCR7
    QuantiTect SYBR Green Assays in human, mouse, rat DHCR7
    QuantiFast Probe-based Assays in human, mouse, rat DHCR7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHCR7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DHCR7 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dhcr71 , 5 7-dehydrocholesterol reductase1, 5 84.85(n)1
    88.75(a)1
      7 (88.33 cM)5
    133601  NM_007856.21  NP_031882.11 
     1438231455 
    chicken
    (Gallus gallus)
    Aves DHCR71 7-dehydrocholesterol reductase 71.66(n)
    76.58(a)
      422982  NM_001199490.1  NP_001186419.1 
    lizard
    (Anolis carolinensis)
    Reptilia DHCR76
    7-dehydrocholesterol reductase
    74(a)
    1 ↔ 1
    1(56029782-56055067)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC054203.12   -- 76.1(n)    BC054203.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dhcr72 7-dehydrocholesterol reductase 78.74(n)   378446  BC055631.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta LBR6
    Lamin B receptor
    12(a)
    1 ↔ 1
    2R(17608002-17611564)
    worm
    (Caenorhabditis elegans)
    Secernentea dhcr-76
    Protein DHCR-7 (dhcr-7) mRNA, complete cds
    20(a)
    1 ↔ 1
    V(20480792-20485385) WBGene00007126
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ERG246
    C-14 sterol reductase, acts in ergosterol biosynth...
    28(a)
    1 → many
    XIV(109095-110411) YNL280C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons DWF51 DWF5 48.81(n)
    39.79(a)
      841465  NM_103926.5  NP_175460.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g04654001 Os02g0465400 49.32(n)
    40.64(a)
      4329318  NM_001053344.1  NP_001046809.1 


    ENSEMBL Gene Tree for DHCR7 (if available)
    TreeFam Gene Tree for DHCR7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DHCR7 gene
    LBR2  TM7SF22  
    2 SIMAP similar genes for DHCR7 using alignment to 10 protein entries:     DHCR7_HUMAN (see all proteins):
    LBR    TM7SF2

    Find genes that share paralogs with DHCR7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DHCR7 (see all 572)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0231814
    Smith-Lemli-Opitz syndrome (SLOS)4--see VAR_0231812 H P mis40--------
    VAR_0231714
    Smith-Lemli-Opitz syndrome (SLOS)4--see VAR_0231712 R Q mis40--------
    VAR_0231624
    Smith-Lemli-Opitz syndrome (SLOS)4--see VAR_0231622 R C mis40--------
    VAR_0231564
    Smith-Lemli-Opitz syndrome (SLOS)4--see VAR_0231562 S L mis40--------
    VAR_0231774
    Smith-Lemli-Opitz syndrome (SLOS)4--see VAR_0231772 R S mis40--------
    VAR_0231764
    Smith-Lemli-Opitz syndrome (SLOS)4--see VAR_0231762 S L mis40--------
    VAR_0231544
    Smith-Lemli-Opitz syndrome (SLOS)4--see VAR_0231542 G D mis40--------
    VAR_0127254
    Smith-Lemli-Opitz syndrome (SLOS)4--see VAR_0127252 T I mis40--------
    VAR_0231634
    Smith-Lemli-Opitz syndrome (SLOS)4--see VAR_0231632 R H mis40--------
    VAR_0231754
    Smith-Lemli-Opitz syndrome (SLOS)4--see VAR_0231752 C Y mis40--------

    HapMap Linkage Disequilibrium report for DHCR7 (71139239 - 71163914 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for DHCR7:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv74n21CNV Loss19592680
    nsv897898CNV Loss21882294
    nsv518163CNV Loss19592680
    nsv897897CNV Loss21882294
    nsv897896CNV Gain21882294

    Human Gene Mutation Database (HGMD): DHCR7
    Locus Specific Mutation Databases (LSDB): DHCR7

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DHCR7
    DNA2.0 Custom Variant and Variant Library Synthesis for DHCR7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602858   
    OMIM disorders: 270400  
    UniProtKB/Swiss-Prot: DHCR7_HUMAN, Q9UBM7
  • Smith-Lemli-Opitz syndrome (SLOS) [MIM:270400]: An autosomal recessive frequent inborn disorder of sterol
    metabolism with characteristic congenital malformations and mental retardation. Children with SLOS have elevated
    serum 7-dehydrocholesterol (7-DHC) levels and low serum cholesterol levels. SLOS occurs in relatively high
    frequency: approximately 1 in 20,000 to 30,000 births in populations of northern and central European background.
    Historically, a clinical distinction often was made between classic ('type I') SLOS and the more severely
    affected ('type II') patients. There is, in reality, a clinical and biochemical continuum from mild to severe
    SLOS. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 5 diseases for DHCR7:    
    About MalaCards
    smith-lemli-opitz syndrome    syndactyly    holoprosencephaly    atrioventricular septal defect
    bardet-biedl syndrome 10

    7 diseases from the University of Copenhagen DISEASES database for DHCR7:
    Smith-Lemli-Opitz syndrome     Syndactyly     Intellectual disability     Atrioventricular septal defect
    Holoprosencephaly     Polydactyly     Autosomal recessive disease

    Find genes that share disorders with DHCR7           About GenesLikeMe

    9 Novoseek inferred disease relationships for DHCR7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    smith-lemli-opitz syndrome 98.9 116 16392899 (3), 11298379 (2), 19406241 (2), 18249054 (2) (see all 75)
    anomaly congenital multiple 88.5 16 10719329 (1), 10899806 (1), 8863875 (1), 11175299 (1) (see all 12)
    mental retardation 77.1 14 10719329 (1), 10899806 (1), 18951487 (1), 8863875 (1) (see all 11)
    holoprosencephaly 74.8 4 8989473 (1), 19449411 (1), 9358606 (1)
    growth failure 50.7 4 10719329 (1), 11001806 (1), 10951458 (1)
    congenital malformation 49.7 2 10329655 (1), 10814720 (1)
    craniofacial anomaly 47.1 1 11001806 (1)
    developmental disabilities 42.9 3 16814115 (1), 11111101 (1)
    genetic disorder 35.4 2 10814720 (1), 11352988 (1)

    GeneTests: DHCR7
    GeneReviews: DHCR7
    Genetic Association Database (GAD): DHCR7
    Human Genome Epidemiology (HuGE) Navigator: DHCR7 (18 documents)

    Export disorders for DHCR7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DHCR7 gene, integrated from 10 sources (see all 179):
    (articles sorted by number of sources associating them with DHCR7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in the human sterol delta 7-reductase gene at 11q12-13 cause Smith-Lemli-Opitz syndrome. (PubMed id 9634533)1, 2, 3, 9 Wassif C.A.... Porter F.D. (Am. J. Hum. Genet. 1998)
    2. Molecular cloning and expression of the human delta7-sterol reductase. (PubMed id 9465114)1, 2, 3 Moebius F.F.... Glossmann H. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    3. Frequency gradients of DHCR7 mutations in patients with Smith-Lemli- Opitz syndrome in Europe: evidence for different origins of common mutations. (PubMed id 11175299)1, 2, 9 Witsch-Baumgartner M.... Utermann G. (Eur. J. Hum. Genet. 2001)
    4. Age and origin of major Smith-Lemli-Opitz syndrome (SLOS) mutations in European populations. (PubMed id 17965227)1, 4, 9 Witsch-Baumgartner M....Utermann G. (J. Med. Genet. 2008)
    5. Identification of nine novel DHCR7 missense mutations in patients with Smith-Lemli-Opitz syndrome (SLOS). (PubMed id 15954111)1, 2, 9 Waye J.S.... Porter F.D. (Hum. Mutat. 2005)
    6. Novel mutations in the 7-dehydrocholesterol reductase gene of 13 patients with Smith-Lemli-Opitz syndrome. (PubMed id 11427181)1, 2, 9 Jira P.E....Waterham H.R. (Ann. Hum. Genet. 2001)
    7. Smith-Lemli-Opitz syndrome is caused by mutations in the 7- dehydrocholesterol reductase gene. (PubMed id 9683613)1, 2, 9 Waterham H.R.... Wanders R.J.A. (Am. J. Hum. Genet. 1998)
    8. SLOS carrier frequency in Poland as determined by screening for Trp151X and Val326Leu DHCR7 mutations. (PubMed id 16497572)1, 4, 9 Ciara E....Krajewska-Walasek M. (Eur J Med Genet 2006)
    9. Maternal apo E genotype is a modifier of the Smith-Lemli-Opitz syndrome. (PubMed id 15286151)1, 4, 9 Witsch-Baumgartner M....Utermann G. (J. Med. Genet. 2004)
    10. DHCR7 mutations and genotype-phenotype correlation in 37 Polish patients with Smith-Lemli-Opitz syndrome. (PubMed id 15521979)1, 4, 9 Ciara E....Krajewska-Walasek M. (Clin. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1717 HGNC: 2860 AceView: DHCR7 Ensembl:ENSG00000172893 euGenes: HUgn1717
    ECgene: DHCR7 Kegg: 1717 H-InvDB: DHCR7

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DHCR7 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=DHCR7[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DHCR7 gene:
    Search GeneIP for patents involving DHCR7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DHCR7  
     OriGene qPCR primer pairs and template standards for DHCR7   OriGene Protein Over-expression Lysate for DHCR7  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DHCR7  
     OriGene qSTAR qPCR primer pairs in human, mouse for DHCR7   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for DHCR7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DHCR7   OriGene Custom Protein Services for DHCR7  

     
     
     Block miRNA regulation of human, mouse, rat DHCR7 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DHCR7
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DHCR7 Predesigned siRNA for gene silencing in human, mouse, rat DHCR7
     QuantiFast Probe-based Assays in human, mouse, rat DHCR7 QuantiTect SYBR Green Assays in human, mouse, rat DHCR7
     PCR Arrays including human, mouse, rat DHCR7 Search Chromatin IP Primers for DHCR7
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DHCR7  Search GeneGlobe Interaction Network for DHCR7
     Regulatory tfbs in DHCR7 promoter
     GenScript Custom Purified and Recombinant Proteins Services for DHCR7 GenScript cDNA clones with any tag delivered in your preferred vector for DHCR7
     GenScript Custom Assay Services for DHCR7 GenScript Custom overexpressing Cell Line Services for DHCR7
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for DHCR7
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DHCR7 antibodies
     DHCR7 proteins
     DHCR7 lysates
     Antibodies for DHCR7
     See all of Abcam's Antibodies, Kits and Proteins for DHCR7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for DHCR7
     Antibodies for DHCR7
     ELISAs for DHCR7
     CLIAs for DHCR7



     Browse ESI BIO Cell Lines and PureStem Progenitors for DHCR7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHCR7
     SwitchGear 3'UTR luciferase reporter plasmids for DHCR7
     SwitchGear Promoter luciferase reporter plasmids for DHCR7
     Search ThermoFisher Antibodies for DHCR7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHCR7
     Browse compounds at ApexBio
     Search Addgene for plasmids for DHCR7
      Search eBioscience for proteins for DHCR7
      Search eBioscience for elisas for DHCR7
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for DHCR7
     antibodies-online antibodies for DHCR7 (23 products)
     antibodies-online kits for DHCR7 (10 products)
     antibodies-online peptides for DHCR7
     antibodies-online proteins for DHCR7 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DHCR7 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4