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DHCR24 Gene

protein-coding GIFtS: 63

GC01M055027

24-dehydrocholesterol reductase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 1.3.1.- ^³
KIAA0018 ^¹, ², ³, ⁵
Nbla03646 ^²
OTTHUMP00000011685 ^²
SELADIN1 ^²
Seladin-1 ^³
seladin-1 ^¹, ²

Descriptions
24-dehydrocholesterol reductase ^²
3 beta-hydroxysterol delta 24-reductase ^²
3-beta-hydroxysterol delta-24-reductase ^³
Diminuto/dwarf1 homolog ^², ³
putative protein product of Nbla03646 ^²
selective AD indicator 1 ^²

External Ids
HGNC: 2859¹
Entrez Gene: 1718²
UniProtKB: Q15392³
Ensembl: ENSG00000116133⁷

Search outside databases for aliases for DHCR24 gene

Previous GC identifers: GC01M055152 GC01M054217 GC01M054659 GC01M054685

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for DHCR24:

This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the

reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The

protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense

mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the

gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been

observed in adrenal gland cancer cells. [provided by RefSeq]

UniProtKB/Swiss-Prot: DHC24_HUMAN, Q15392

Function: Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects

cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative

stress. Also protects against amyloid-beta peptide-induced apoptosis

Gene Wiki entry for DHCR24 (24-dehydrocholesterol_reductase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the DHCR24 gene

Entrez Gene cytogenetic band: 1p33-p31.1 Ensembl cytogenetic band: 1p32.3 HGNC cytogenetic band: 1p32.3

DHCR24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M055027: (about GC identifiers)

Start:	55,087,888 bp from pter
End:	55,125,509 bp from pter
Size:	37,622 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_032977.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: DHC24_HUMAN, Q15392 (See protein sequence)

Recommended Name: 24-dehydrocholesterol reductase precursor

Size: 516 amino acids; 60101 Da

Cofactor: FAD

Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus

membrane; Single-pass membrane protein

Secondary accessions: Q9HBA8

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_055577.1

ENSEMBL proteins:

ENSP00000360316

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Seladin 1)
	Human Recombinant Proteins from Abnova (DHCR24)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0005634	nucleus	IDA	15577914
GO:0005783	endoplasmic reticulum	IDA	11007892
GO:0005789	endoplasmic reticulum membrane	NAS	11007892
GO:0005794	Golgi apparatus	IEA	--

About this table

Antibodies for DHCR24:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for DHCR24
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for DHCR24 (DHCR24/Seladin-1)
	Antibodies from Abcam (Seladin 1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (DHCR24)
	Novus Biologicals Antibody for DHCR24

Assays for DHCR24:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q15392

ProtoNet protein and cluster: Q15392

UniProtKB/Swiss-Prot: DHC24_HUMAN, Q15392

Similarity: Belongs to the FAD-binding oxidoreductase/transferase type 4 family

Similarity: Contains 1 FAD-binding PCMH-type domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DHCR24)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014762

Applied Biosystems Silencer® siRNAs for DHCR24

Sigma-Aldrich siRNA for DHCR24

Sigma-Aldrich shRNA for DHCR24

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for DHCR24
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_014762
Myc/DDK tagged cDNA clone in CMV expression vector: NM_014762
untagged cDNA clone in CMV expression vector: NM_014762

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_014762

UniProtKB/Swiss-Prot: DHC24_HUMAN, Q15392

Function: Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects

cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative

stress. Also protects against amyloid-beta peptide-induced apoptosis

Enzyme Number (IUBMB): EC 1.3.1.-

6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dhcr24):

adipose tissue	endocrine/exocrine gland	growth/size	homeostasis/metabolism	lethality-prenatal/perinatal
reproductive system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016491	oxidoreductase activity	IEA	--
GO:0019899	enzyme binding	IPI	15577914
GO:0042605	peptide antigen binding	IPI	15577914
GO:0050614	delta24-sterol reductase activity	EXP	11519011
GO:0050660	FAD binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

4 Sigma-Aldrich "Your Favorite Gene" Pathways for DHCR24 (Your Favorite Gene powered by Ingenuity)

Propanoate Metabolism
Inositol Metabolism
Phenylalanine Metabolism
Tryptophan Metabolism

GeneDecks DHCR24 for the pathways selected above

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UniProtKB/Swiss-Prot: DHC24_HUMAN, Q15392

Pathway: Steroid biosynthesis; cholesterol biosynthesis

Gene Network Central^TM Interacting Genes and Proteins Network for DHCR24

5/16 Interacting proteins for DHCR24 (ENSP00000360316³) via UniProtKB, MINT, and/or STRING (see all 16 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DHCR7	ENSP00000347717³	STRING (score=.964)
TP53	ENSP00000269305³	STRING (score=.961)
CYP51A1	ENSP00000003100³	STRING (score=.946)
LSS	ENSP00000348762³	STRING (score=.899)
SC4MOL	ENSP00000261507³	STRING (score=.899)

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5/15 Gene Ontology (GO) biological process terms (links to tree view) (see all 15 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006695	cholesterol biosynthetic process	NAS	11519011
GO:0006915	apoptosis	NAS	11007892
GO:0006916	anti-apoptosis	IDA	15688385
GO:0006979	response to oxidative stress	IEP	11007892
GO:0007050	cell cycle arrest	NAS	15577914

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DHCR24
4 Novoseek chemical compound relationships for DHCR24 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
3beta-hydroxysterol	96.06	5	15688385 (1), 11519011 (1), 15001630 (1), 18768664 (1)
desmosterol	94.62	14	12457401 (3), 17094431 (1), 16762343 (1), 15001630 (1) (see all 8)
cholesterol	61.68	38	17984220 (3), 15688385 (2), 18394665 (2), 17510943 (2) (see all 17)
sterol	56.95	5	17984220 (1), 11519011 (1), 12457401 (1), 19283968 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DHCR24)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014762

Sigma-Aldrich siRNA for DHCR24

Sigma-Aldrich shRNA for DHCR24

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_014762

REFSEQ mRNAs for DHCR24 gene:

NM_014762.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_014762

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014762
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_014762
                                 untagged cDNA clone in CMV expression vector: NM_014762

Additional cDNA sequence:

AB073391.1 AF261758.1 AK298414.1 AK302774.1 AK304302.1 AK304421.1 AK304437.1 AK316419.1

AK316427.1 BC004375.1 BC011669.2 CR609488.1 D13643.3

24/45 DOTS entries (see all 45 ):

DT.95228106 DT.100885748 DT.100885752 DT.449037 DT.91882207 DT.100885762 DT.95344396 DT.121395022

DT.91773850 DT.95272537 DT.100885753 DT.100885751 DT.121395011 DT.121395026 DT.121394969 DT.100885756

DT.121394983 DT.121394986 DT.75119490 DT.91773843 DT.99976414 DT.100885733 DT.121394960 DT.121395028

24/894 AceView cDNA sequences (see all 894 ):

BU191126 BU859061 BQ925619 BU146312 BE747340 BU166631 BC011669 BM564549

BP338861 BI060615 BM561620 BU172322 BM753988 CF145147 AU131512 AU131997

BM745855 AL046697 AU132109 BU191046 BE745944 CR609488 BG248956 AA774904

highest scoring ESTs for DHCR24:

D13643 AF261758 AL119964 AL559719 AL701503 AL701520 AU128814 AU130393 AU131476 AU131512

Unigene Cluster for DHCR24:

24-dehydrocholesterol reductase

Hs.498727 [show with all ESTs]

Unigene Representative Sequence: NM_014762

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for DHCR24

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13
SP1:											-		-																-
SP2:
SP3:													-
SP4:											-
SP5:							-				-		-

About this scheme

ECgene alternative splicing isoforms for DHCR24

1 Ensembl transcript including schematic representation:

ENST00000371269

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

DHCR24 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for DHCR24

¹ / ² / ³

4 probe-sets matching DHCR24 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
74557_s_at²^{, 3}	U95-D	1	1.00	1.00	0.99	1.12	AI739473	0.40	1.00	0.76	1
36658_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.88	D13643	1.00	1.00	1.00	1
200862_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_014762	0.60	1.00	0.82	1
200862_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks DHCR24 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCCCCGTGGC

SOURCE GeneReport for Unigene cluster: Hs.498727
Expression variation in blood from EXPOLDB for DHCR24
UniProtKB/Swiss-Prot: DHC24_HUMAN, Q15392
Tissue specificity: Highly expressed in brain and adrenal gland with moderate expression in liver,
lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable
in blood cells. In the brain, strongly expressed in cortical regions, substantia nigra, caudate
nucleus, hippocampus, medulla oblongata and pons. In brains affected by Alzheimer disease,
expression in the inferior temporal lobe is substantially lower than in the frontal cortex

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for DHCR24 gene from 5/14 species (see all 14 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	DHCR24¹	--	24-dehydrocholesterol reductase	92.89(n) 96.9(a)	489573 XM_546693.2 XP_546693.2
chimpanzee (Pan troglodytes)	DHCR24¹	--	24-dehydrocholesterol reductase	99.22(n) 99.81(a)	456879 XM_001153930.1 XP_001153930.1
rat (Rattus norvegicus)	Dhcr24¹	--	24-dehydrocholesterol reductase	90.96(n) 97.09(a)	298298 XM_216452.4 XP_216452.4
mouse (Mus musculus)	Dhcr24^{1, 5}	4⁵	24-dehydrocholesterol reductase^{1, 5}	91.34(n)¹ 96.9(a)¹	74754¹ NM_053272.2¹ NP_444502.2¹ AI849109⁵ AK010192⁵ (see all 14)
chicken (Gallus gallus)	DHCR24¹	--	24-dehydrocholesterol reductase	76.16(n) 78.29(a)	424661 NM_001031288.1 NP_001026459.1

About this table Species with no ortholog for DHCR24

ENSEMBL Gene Tree for DHCR24

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/288 NCBI SNPs in DHCR24 are shown (see all 288 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 97)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs7373^1,2	A,C,F,H,O	55088199(+)	`GAGAGG/CCTTAC`	1	--	ut3¹		7	MN EU EA WA	2256
	rs2274941^1,2	A,C,F,H,O	55125958(+)	`CACTTT/GCCACG`	1	--	ng3¹		14	EA NA MN EU WA	2856
	rs4927176^1,2	A,C,F,H	55126923(+)	`TCTTAC/TACAAC`	1	--	ng3¹		8	EU EA WA	838
	rs3170766^1,2	A,C,F,H	55126890(+)	`GACTTC/AAAAAA`	1	--	ng3¹		13	MN EU EA WA	1434
--	rs669181^1,2	A,C,F,H	55087676(-)	`gggtgA/Gcaagc`	1	--	ng5¹		4	EU EA WA	420
	rs7374^1,2	A,C,F,H	55088910(-)	`CAAGGC/TCAGCT`	1	--	ut3¹		11	MN EA EU WA NA	2434
	rs6588537^1,2	A,C,F,H	55126781(+)	`tttgtG/Acacag`	1	--	ng3¹		4	EU EA WA	410
	rs6588536^1,2	A,C,F,H	55126776(+)	`ggtgcT/Gttgtg`	1	--	ng3¹		4	EU EA WA	418
--	rs1138030^1,2	C,F,H	55090273(-)	`TTCCCC/TGTTTA`	1	--	ut3¹ ese³		6	EA EU WA MN	2060
--	rs6681644^1,2	A,C,F	55125670(+)	`AGGGAC/GTGGGT`	1	--	ng3¹		2	EA MN	400

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HapMap Linkage Disequilibrium images for DHCR24 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 606418 disorders: 602398

UniProtKB/Swiss-Prot: DHC24_HUMAN, Q15392

Defects in DHCR24 are the cause of desmosterolosis [MIM:602398]. It is a rare autosomal

recessive disorder characterized by multiple congenital anomalies and elevated levels of the

cholesterol precursor desmosterol in plasma, tissue, and cultured cells

4 Novoseek disease relationships for DHCR24 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
desmosterolosis	92.63	6	11519011 (2), 16410790 (2), 12457401 (1)
alzheimers disease	69.32	14	17984220 (1), 16762343 (1), 17510943 (1), 18434374 (1) (see all 10)
adenoma	14.31	1	16091489 (1)
cancer	0.00	1	16455181 (1)

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Human Gene Mutation Database: DHCR24
Human Genome Epidemiology Navigator: DHCR24 (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/41 PubMed articles for DHCR24 gene (see all 41 ):

Mutations in the 3beta-hydroxysterol delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis. (PubMed id 11519011)^{1, 2, 3, 4} Waterham H.R.... Wanders R.J.A. (2001)
The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress. (PubMed id 11007892)^{1, 3, 4} Greeve I.... Nitsch R.M. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)^{3, 4} Nomura N....Tabata S. (1994)
DHCR24 gene expression is upregulated in melanoma metastases and associated to resistance to oxidative stress-induced apoptosis. (PubMed id 15688385)^{1, 3} Di Stasi D....Rodolfo M. (2005)
Prosurvival effect of DHCR24/Seladin-1 in acute and chronic responses to oxidative stress. (PubMed id 17984220)^{1, 3} Kuehnle K....Mohajeri M.H. (2008)
Seladin-1 is a fundamental mediator of the neuroprotective effects of estrogen in human neuroblast long-term cell cultures. (PubMed id 18499757)^{1, 3} Luciani P....Peri A. (2008)
Seladin-1 as a target of estrogen receptor activation in the brain: a new gene for a rather old story? (PubMed id 15954227)^{1, 3} Peri A....Serio M. (2005)
Regulation of cellular response to oncogenic and oxidative stress by Seladin-1. (PubMed id 15577914)^{1, 3} Wu C....Galaktionov K. (2004)
Neuronal differentiation of human mesenchymal stem cells: changes in the expression of the Alzheimer's disease-related gene seladin-1. (PubMed id 16762343)^{1, 3} Benvenuti S....Peri A. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1718	HGNC: 2859	AceView: DHCR24	Ensembl:ENSG00000116133	euGenes: HUgn1718
ECgene: DHCR24	H-InvDB: DHCR24

(According to HUGE)
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HUGE: KIAA0018

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for DHCR24	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=DHCR24

Licensable Technologies for DHCR24
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for DHCR24:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for DHCR24-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for DHCR24		Antibodies for DHCR24
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for DHCR24		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (DHCR24)
	Antibodies (DHCR24)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for DHCR24 (DHCR24/Seladin-1)

	Recombinant Proteins (Seladin 1)
	Antibodies (Seladin 1)

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Antibodies for DHCR24

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DHCR24 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for DHCR24

Summaries
for DHCR24

Genomic Location
for DHCR24

Proteins
for DHCR24

Protein Domains/
Families
for DHCR24

Gene Function
for DHCR24

Pathways & Interactions
for DHCR24

Drugs & Compounds
for DHCR24

Transcripts
for DHCR24

Expression
for DHCR24

Orthologs
for DHCR24

Paralogs
for DHCR24

SNPs/Variants
for DHCR24

Disorders & Mutations
for DHCR24

Medical News
for DHCR24

Publications
for DHCR24

Search for DHCR24

Genome Databases showing DHCR24

Other Databases showing DHCR24

Specialized Databases showing DHCR24

Licensable Technologies
for DHCR24

Services
for DHCR24

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

DHCR24 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor DHCR24

Summariesfor DHCR24

Genomic Locationfor DHCR24

Proteinsfor DHCR24

Protein Domains/Familiesfor DHCR24

Gene Functionfor DHCR24

Pathways & Interactionsfor DHCR24

Drugs & Compoundsfor DHCR24

Transcriptsfor DHCR24

Expression for DHCR24

Orthologsfor DHCR24

Paralogsfor DHCR24

SNPs/Variantsfor DHCR24

Disorders & Mutationsfor DHCR24

Medical Newsfor DHCR24

Publicationsfor DHCR24

Search for DHCR24

Genome Databases showing DHCR24

Other Databases showing DHCR24

Specialized Databases showing DHCR24

Licensable Technologiesfor DHCR24

Servicesfor DHCR24

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for DHCR24

Summaries
for DHCR24

Genomic Location
for DHCR24

Proteins
for DHCR24

Protein Domains/
Families
for DHCR24

Gene Function
for DHCR24

Pathways & Interactions
for DHCR24

Drugs & Compounds
for DHCR24

Transcripts
for DHCR24

Expression
for DHCR24

Orthologs
for DHCR24

Paralogs
for DHCR24

SNPs/Variants
for DHCR24

Disorders & Mutations
for DHCR24

Medical News
for DHCR24

Publications
for DHCR24

Licensable Technologies
for DHCR24

Services
for DHCR24