DGUOK Gene
protein-coding GIFtS: 63
GCID: GC02P074153
|
|
deoxyguanosine kinase
| |
Aliases
for DGUOK gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Deoxyguanosine Kinase1 2 | | DGK3 5 | | MTDPS32 5 | | DGK3 5 | | Deoxyguanosine Kinase, Mitochondrial2 | | EC 2.7.1.1133 |
Export aliases for DGUOK gene to outside databasesPrevious GC identifers: GC02P074291 GC02P074111 GC02P074128 GC02P074065 GC02P073889 |
Summaries
for DGUOK gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DGUOK:
In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by twodeoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The proteinencoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. Inaddition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment oflymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternativesplice variants encoding different protein isoforms have been described for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: DGUOK_HUMAN, Q16854Function: Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widelyemployed as antiviral and chemotherapeutic agents
Gene Wiki entry for DGUOK
|
Genomic Views
for DGUOK gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DGUOK gene promoter:
GR AML1a GR-beta ATF-2 XBP-1 LCR-F1 RORalpha2 CRE-BP1 Pax-3 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for DGUOK
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DGUOK |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p13 Ensembl cytogenetic band: 2p13.1 HGNC cytogenetic band: 2p13DGUOK Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P074153: view genomic region
(about GC identifiers)
Start:
|
74,153,953 bp from pter |
End:
|
74,186,088 bp from pter |
Size:
|
32,136 bases |
Orientation:
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plus strand |
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Proteins
for DGUOK gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DGUOK_HUMAN, Q16854 (See
protein sequence)Recommended Name: Deoxyguanosine kinase, mitochondrial precursor Size: 277 amino acids; 32056 Da
Subunit: Homodimer
Subcellular location: Mitochondrion
1 PDB 3D structure from  and Proteopedia  for DGUOK:2OCP (3D)
Secondary accessions: P78532 Q16759 Q4ZG09 Q96BC1Alternative splicing: 5 isoforms: Q16854-1 Q16854-2 Q16854-3 Q16854-4 Q16854-5 Explore the universe of human proteins at neXtProt for DGUOK: NX_Q16854
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q16854
DGUOK Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_550438.1 NP_550440.1
ENSEMBL proteins: ENSP00000264093 ENSP00000306964 ENSP00000408209 ENSP00000349294 Reactome Protein details: Q16854
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
DGUOK for ontologies About GeneDecksing
DGUOK Antibody Products:
Assay Products for DGUOK: |
Protein
Domains /
Families
for DGUOK gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DGUOK for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q16854ProtoNet protein and cluster: Q16854 1 Blocks protein family: IPB002624 Deoxynucleoside kinase
UniProtKB/Swiss-Prot: DGUOK_HUMAN, Q16854Similarity: Belongs to the DCK/DGK family |
Function
for DGUOK gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DGUOK_HUMAN, Q16854Function: Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widelyemployed as antiviral and chemotherapeutic agentsCatalytic activity: ATP + deoxyguanosine = ADP + dGMP Genatlas biochemistry entry for DGUOK:deoxyguanosine kinase,mitochondrial,related to DCK
Enzyme Number (IUBMB): EC 2.7.1.1131
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DGUOK (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DGUOK (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): DGUOK (NM_080916) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DGUOK | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DGUOK |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGUOK |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
DGUOK for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for DGUOK:
|
Pathways & Interactions
for DGUOK gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Purine metabolism | | | 2 | Metabolism | | | 3 | Purine metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for DGUOK
2 
Kegg Pathways (Kegg details for DGUOK):
DGUOK for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DGUOK
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/14 Interacting proteins for DGUOK (Q168543 ENSP000002640934) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006139 | nucleobase-containing compound metabolic process |
-- | -- | | GO:0006144 | purine nucleobase metabolic process |
TAS | -- | | GO:0006468 | protein phosphorylation |
IEA | -- | | GO:0008617 | guanosine metabolic process |
TAS | 8692979 | | GO:0009165 | nucleotide biosynthetic process |
EXP | -- |
DGUOK for ontologies About GeneDecksing
|
Drugs & Compounds
for DGUOK gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DGUOK for compounds About GeneDecksing
 Browse Tocris compounds for DGUOK
4 HMDB Compounds for DGUOK About this table
1 DrugBank Compound for DGUOK About this table
10/29 Novoseek chemical compound relationships for DGUOK gene (see all 29) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| deoxyguanosine |
97.1 |
216 |
12874104 (7), 7918681 (5), 10951205 (4), 9776315 (4) (see all 95) |
| 9-(beta-d-arabinofuranosyl)guanine |
94.7 |
18 |
9776315 (4), 11463492 (2), 8706825 (1), 9463485 (1) (see all 6) |
| deoxycytidine |
94.2 |
83 |
9427844 (3), 9593124 (3), 12744603 (3), 9342341 (2) (see all 44) |
| deoxynucleoside |
92 |
14 |
8706825 (1), 12535661 (1), 11000580 (1), 15628745 (1) (see all 8) |
| 2',2'-difluorodeoxyguanosine |
88.8 |
11 |
9776315 (4), 9614068 (1) |
| deoxyadenosine |
86.5 |
17 |
11687801 (1), 9054375 (1), 9427844 (1), 9756902 (1) (see all 11) |
| 2-chlorodeoxyadenosine |
82.3 |
28 |
9776315 (5), 7901204 (2), 16436271 (2), 8706825 (1) (see all 9) |
| nucleoside |
79.9 |
22 |
9463485 (3), 9614068 (3), 18600530 (2), 9776315 (2) (see all 9) |
| 2',3'-dideoxyguanosine |
78.7 |
2 |
11181353 (1) |
| deoxyribonucleotide |
77.3 |
5 |
12391347 (1), 18723380 (1), 15921863 (1), 12873860 (1) |
Search CenterWatch for drugs/clinical trials and news about DGUOK
|
Transcripts
for DGUOK gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DGUOK gene (5 alternative transcripts): NM_080916.2 NM_080918.2 NM_001929.2 NM_080915.1 NM_080917.1 Unigene Cluster for DGUOK: Deoxyguanosine kinase Hs.469022 [show with all ESTs]Unigene Representative Sequence: NM_0809168 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000264093(uc002sjx.3) ENST00000348222(uc002sjy.3 uc002sjz.3)
ENST00000418996 ENST00000462551 ENST00000489796 ENST00000462685 ENST00000493055
ENST00000356837
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DGUOK (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DGUOK (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): DGUOK (NM_080916) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DGUOK | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DGUOK |
Additional cDNA sequence: BC001121.2 BC015757.1 BC024019.1 U41668.1 24/26 DOTS entries (see all 26): DT.453909 DT.95304525 DT.100825818 DT.100825815 DT.95304529 DT.121009504 DT.121009476 DT.92436943 DT.65286224 DT.70101216 DT.95304527 DT.97862525 DT.102827671 DT.121009492 DT.121009480 DT.121009519 DT.92436939 DT.92476815 DT.121009470 DT.121009489 DT.121009502 DT.92436938 DT.92436941 DT.95342984 24/332 AceView cDNA sequences (see all 332): AI733600 BU580854 U41668 CB112238 BQ673753 AW027181 BG818539 CA848273 AA872772 BU553514 AV658486 BM973502 BM809666 BG756148 NM_080915 BX100050 BU624570 AI884894 NM_001929 CD365206 BQ224612 CB123900 BC015757 BQ222872
GeneLoc Exon Structure
5/16 Alternative Splicing Database (ASD) splice patterns (SP) for DGUOK (see all 16) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | · | 9e |
|---|
|
| SP1: | | | | | | | | | - | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | - | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DGUOK
|
Expression
for DGUOK gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DGUOK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGTTCAGGC
About this image
See DGUOK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DGUOK
SOURCE GeneReport for Unigene cluster: Hs.469022
UniProtKB/Swiss-Prot: DGUOK_HUMAN, Q16854Tissue specificity: Ubiquitous. Highest expression in muscle, brain, liver and lymphoid tissues
SABiosciences Custom PCR Arrays for DGUOK
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DGUOK
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DGUOK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DGUOK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DGUOK | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGUOK |
Orthologs
for DGUOK gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DGUOK gene from 5/14 species (see all 14) About this table
ENSEMBL Gene Tree for DGUOK (if available)
TreeFam Gene Tree for DGUOK (if available) |
Paralogs
for DGUOK gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DGUOK gene
- TK22 DCK2
2 SIMAP similar genes for DGUOK using alignment to 4 protein entries: DGUOK_HUMAN (see all proteins):DCK TK2
DGUOK for paralogs About GeneDecksing
|
Genomic Variants
for DGUOK gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DGUOK (74153953 - 74186088 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DGUOK: --
Human Gene Mutation Database (HGMD): DGUOK
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DGUOK |
|
Disorders
/ Diseases
for DGUOK gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DGUOK for disorders About GeneDecksing
OMIM gene information: 601465
OMIM disorders: 251880
UniProtKB/Swiss-Prot: DGUOK_HUMAN, Q16854
Defects in DGUOK are the cause of mitochondrial DNA depletion syndrome type 3 (MTDPS3) [MIM:251880]. Adisorder characterized by onset in infancy of progressive liver failure, hypoglycemia, increased lactate in bodyfluids, and neurologic abnormalities including hypotonia, encephalopathy, peripheral neuropathy. Affected tissues showboth decreased activity of the mtDNA-encoded respiratory chain complexes and mtDNA depletion
20/33  diseases for DGUOK (see all 33): About MalaCardsdguok-related mitochondrial dna depletion syndrome, hepatocerebral form mitochondrial dna depletion syndrome, hepatocerebral form mitochondrial dna depletion syndrome mitochondrial dna depletion syndrome 3 (hepatocerebral type)
purine nucleoside phosphorylase deficiency nucleoside phosphorylase deficiency mitochondrial dna depletion myopathy chronic progressive external ophthalmoplegia
muscle glycogenosis alpers syndrome cystathioninuria muscular atrophy
pearson syndrome ophthalmoplegia n syndrome lymphocytic leukemia
peripheral neuropathy chronic lymphocytic leukemia myopathy hepatitis b
1 disease from the University of Copenhagen DISEASES database for DGUOK:Mitochondrial myopathy 10/15 Novoseek disease relationships for DGUOK gene (see all 15) About this table
GeneTests: DGUOK
DGUOK-Related Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form
Human Genome Epidemiology (HuGE) Navigator: DGUOK (2 documents)
Export disorders for DGUOK gene to outside databases
|
Publications
for DGUOK gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DGUOK gene, integrated from 9 sources (see all 133):
(articles sorted by number of sources associating them with DGUOK) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes. (PubMed id 15639197)1, 2, 9 Wang L....Eriksson S. (2005)
- Cloning and expression of human deoxyguanosine kinase cDNA. (PubMed id 8692979)1, 2, 9 Johansson M. and Karlsson A. (1996)
- Mitochondrial DNA depletion and dGK gene mutations. (PubMed id 12205643)1, 2, 9 Salviati L.... Vu T.H. (2002)
- Cloning and expression of human mitochondrial deoxyguanosine kinase cDNA. (PubMed id 8706825)1, 2, 9 Wang L.... Eriksson S. (1996)
- Structural basis for substrate specificities of cellular deoxyribonucleoside kinases. (PubMed id 11427893)1, 2, 9 Johansson K....Eklund H. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Depletion of mitochondrial DNA by down-regulation of deoxyguanosine kinase expression in non-proliferating HeLa cells. (PubMed id 17490647)1, 9 Franco M....Karlsson A. (2007)
- A novel c.592-4_c.592-3delTT mutation in DGUOK gene c auses exon skipping. (PubMed id 19900589)1, 9 Ji J.Q....Wong L.J. (2010)
- Kinetic properties of mutant deoxyguanosine kinase in a case of reversible hepatic mtDNA depletion. (PubMed id 17073823)1, 9 Mousson de Camaret B....Bozon D. (2007)
- The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA. (PubMed id 11687800)1, 9 Mandel H....Cohen N. (2001)
|
External Searches for DGUOK gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DGUOK gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DGUOK gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DGUOK gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DGUOK | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/DGUOK |
|
| | |
About This Section
| Patent Information for DGUOK gene:
Search GeneIP for patents involving DGUOK
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DGUOK gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DGUOK | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DGUOK | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DGUOK | | | OriGene Protein Over-expression Lysate for DGUOK | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DGUOK | | OriGene 3'-UTR Clone for DGUOK | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DGUOK | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DGUOK | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DGUOK | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DGUOK | | OriGene Custom Protein Services for DGUOK | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DGUOK | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DGUOK | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DGUOK | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DGUOK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DGUOK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DGUOK |
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| | | | Search Tocris compounds for DGUOK |
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 | | | DGUOK Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGUOK |
|  |  |  | | | | ThermoFisher Antibodies for DGUOK |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DGUOK |
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