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Aliases for DGKZ Gene

Aliases for DGKZ Gene

  • Diacylglycerol Kinase Zeta 2 3 5
  • Diacylglycerol Kinase, Zeta 104kDa 2 3
  • Diglyceride Kinase Zeta 3 4
  • DAG Kinase Zeta 3 4
  • EC 2.7.1.107 4 61
  • DGK-ZETA 3 4
  • DAGK6 3 4
  • HDGKzeta 3
  • DAGK5 3

External Ids for DGKZ Gene

Previous GeneCards Identifiers for DGKZ Gene

  • GC11P048153
  • GC11P047058
  • GC11P046398
  • GC11P046333
  • GC11P046318
  • GC11P046311
  • GC11P046061
  • GC11P046354

Summaries for DGKZ Gene

Entrez Gene Summary for DGKZ Gene

  • The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010]

GeneCards Summary for DGKZ Gene

DGKZ (Diacylglycerol Kinase Zeta) is a Protein Coding gene. Among its related pathways are Effects of PIP2 hydrolysis and RET signaling. GO annotations related to this gene include protein C-terminus binding and NAD+ kinase activity. An important paralog of this gene is DGKI.

UniProtKB/Swiss-Prot for DGKZ Gene

  • Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity.

Tocris Summary for DGKZ Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.

Gene Wiki entry for DGKZ Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGKZ Gene

Genomics for DGKZ Gene

Regulatory Elements for DGKZ Gene

Enhancers for DGKZ Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G046288 1.6 Ensembl ENCODE dbSUPER 11.7 -38.3 -38331 11.9 HNRNPUL1 HDGF PKNOX1 ARNT AGO1 ZFP64 ARID4B SIN3A YY1 ZNF766 DGKZ MDK CHST1 LRP4 CKAP5 MADD C11orf49 CREB3L1 GC11P046331
GH11G046270 1.6 Ensembl ENCODE dbSUPER 10.7 -56.4 -56390 12.2 HDGF FOXA2 PKNOX1 MLX ARNT AGO1 ZFP64 ARID4B SIN3A ZBTB7B DGKZ CHST1 MADD LRP4 ARHGAP1 PACSIN3 LINC02489 CREB3L1
GH11G046308 1.3 Ensembl ENCODE dbSUPER 12.3 -24.0 -23980 1.0 HDGF ATF1 CBX3 RB1 SIN3A ZNF2 RAD21 ZNF143 RCOR1 CREM DGKZ LINC02489 CREB3L1 MDK C11orf49 NR1H3 GC11P046331
GH11G046552 1.3 Ensembl ENCODE 10.7 +222.7 222721 5.5 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 SLC30A9 ATG13 AMBRA1 HARBI1 CHRM4 MDK DGKZ C11orf49 ZNF408 MIR3160-1
GH11G046309 1.1 ENCODE dbSUPER 12.3 -23.0 -23017 0.7 HDAC1 HDGF PKNOX1 ZNF335 ZNF366 FOS BCLAF1 SMARCA5 SP3 SMARCC1 DGKZ CREB3L1 LINC02489 MDK GC11P046331
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DGKZ on UCSC Golden Path with GeneCards custom track

Promoters for DGKZ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000039522 195 601 PKNOX1 SUZ12 HLF RBBP5 DPF2 ZBTB7A EP300 ZFHX2 PBX2 GLIS1

Genomic Location for DGKZ Gene

Chromosome:
11
Start:
46,332,905 bp from pter
End:
46,380,554 bp from pter
Size:
47,650 bases
Orientation:
Plus strand

Genomic View for DGKZ Gene

Genes around DGKZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGKZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGKZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKZ Gene

Proteins for DGKZ Gene

  • Protein details for DGKZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13574-DGKZ_HUMAN
    Recommended name:
    Diacylglycerol kinase zeta
    Protein Accession:
    Q13574
    Secondary Accessions:
    • B7Z2M9
    • B7Z6M3
    • E9PPW4
    • F6UCU9
    • G3V0F6
    • J3KNJ6
    • O00542
    • Q6ZVG7
    • Q8IVW9

    Protein attributes for DGKZ Gene

    Size:
    1117 amino acids
    Molecular mass:
    124128 Da
    Quaternary structure:
    • Interacts with the PDZ domain of the syntrophin SNTG1 and that of SNX27. Isoform 2 forms a signaling complex with RASGRP1 and HRAS.
    SequenceCaution:
    • Sequence=AAB60859.1; Type=Frameshift; Positions=166, 167; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DGKZ Gene

    Alternative splice isoforms for DGKZ Gene

neXtProt entry for DGKZ Gene

Selected DME Specific Peptides for DGKZ Gene

Q13574:
  • RIDRAQEHL
  • CGGDGTVGW
  • SLAALQVGGHGERL
  • HHDFEPQRHDDGY
  • PEKFNSR
  • VNPKSGG
  • CGKGFQQKF
  • PLGTGNDL
  • IEEPCSLG
  • DLTPKIQ
  • WYLNPRQVFDLSQ
  • FVRHHWVHRRRQ
  • PVQVDGE
  • ETNVSGD
  • FHSKEIVAISCSWCKQA

Post-translational modifications for DGKZ Gene

  • Phosphorylation of the MARCKS homology domain by PKC reduces nuclear accumulation of DGK-zeta.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DGKZ Gene

Gene Families for DGKZ Gene

Graphical View of Domain Structure for InterPro Entry

Q13574

UniProtKB/Swiss-Prot:

DGKZ_HUMAN :
  • Belongs to the eukaryotic diacylglycerol kinase family.
Family:
  • Belongs to the eukaryotic diacylglycerol kinase family.
genes like me logo Genes that share domains with DGKZ: view

Function for DGKZ Gene

Molecular function for DGKZ Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot Function:
Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity.

Enzyme Numbers (IUBMB) for DGKZ Gene

Gene Ontology (GO) - Molecular Function for DGKZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003951 NAD+ kinase activity IEA --
GO:0004143 diacylglycerol kinase activity IEA,TAS --
GO:0005515 protein binding IPI 17664281
GO:0005524 ATP binding IEA,TAS --
GO:0016301 kinase activity IDA 18004883
genes like me logo Genes that share ontologies with DGKZ: view
genes like me logo Genes that share phenotypes with DGKZ: view

Animal Models for DGKZ Gene

MGI Knock Outs for DGKZ:

Animal Model Products

  • Taconic Biosciences Mouse Models for DGKZ

CRISPR Products

miRNA for DGKZ Gene

miRTarBase miRNAs that target DGKZ

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DGKZ Gene

Localization for DGKZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGKZ Gene

Cytoplasm. Nucleus. Cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DGKZ gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for DGKZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 15157668
GO:0005737 cytoplasm TAS 11309392
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with DGKZ: view

Pathways & Interactions for DGKZ Gene

genes like me logo Genes that share pathways with DGKZ: view

Gene Ontology (GO) - Biological Process for DGKZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0016310 phosphorylation IEA --
GO:0016477 cell migration NAS 15157668
GO:0030168 platelet activation TAS --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with DGKZ: view

No data available for SIGNOR curated interactions for DGKZ Gene

Drugs & Compounds for DGKZ Gene

(4) Drugs for DGKZ Gene - From: HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Dioctanoylglycol Pharma Diacylglycerol kinase inhibitor 0
R 59-022 Pharma Diacylglycerol kinase inhibitor; increases PKC activity 0

(22) Additional Compounds for DGKZ Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
LPA(0:0/16:0)
  • 2-Hexadecanoyl-phosphatidic acid
  • 2-Palmitoyl-glycero-3-phosphate
  • LPA(0:0/16:0)
  • LPA(16:0)
  • Lysophosphatidic acid(0:0/16:0)

(2) Tocris Compounds for DGKZ Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor 627-86-1
R 59-022 Diacylglycerol kinase inhibitor; increases PKC activity 93076-89-2
genes like me logo Genes that share compounds with DGKZ: view

Transcripts for DGKZ Gene

Unigene Clusters for DGKZ Gene

Diacylglycerol kinase, zeta:
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DGKZ Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - - - -
SP14:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31a · 31b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for DGKZ Gene

GeneLoc Exon Structure for
DGKZ
ECgene alternative splicing isoforms for
DGKZ

Expression for DGKZ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DGKZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DGKZ Gene

This gene is overexpressed in Brain - Cortex (x4.6) and Brain - Hippocampus (x4.0).

Protein differential expression in normal tissues from HIPED for DGKZ Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.9), Heart (13.8), and CD8 Tcells (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DGKZ Gene



Protein tissue co-expression partners for DGKZ Gene

NURSA nuclear receptor signaling pathways regulating expression of DGKZ Gene:

DGKZ

SOURCE GeneReport for Unigene cluster for DGKZ Gene:

Hs.502461

mRNA Expression by UniProt/SwissProt for DGKZ Gene:

Q13574-DGKZ_HUMAN
Tissue specificity: Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas. Isoform 1 is predominantly expressed in muscle.

Evidence on tissue expression from TISSUES for DGKZ Gene

  • Nervous system(4.9)
  • Muscle(4.5)
  • Heart(4.4)
  • Liver(4.1)
  • Kidney(3.2)
genes like me logo Genes that share expression patterns with DGKZ: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DGKZ Gene

Orthologs for DGKZ Gene

This gene was present in the common ancestor of animals.

Orthologs for DGKZ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DGKZ 34 35
  • 99.67 (n)
cow
(Bos Taurus)
Mammalia DGKZ 34 35
  • 91.91 (n)
dog
(Canis familiaris)
Mammalia DGKZ 34 35
  • 89.84 (n)
rat
(Rattus norvegicus)
Mammalia Dgkz 34
  • 88.9 (n)
mouse
(Mus musculus)
Mammalia Dgkz 34 16 35
  • 86.29 (n)
oppossum
(Monodelphis domestica)
Mammalia DGKZ 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DGKZ 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves DGKZ 34 35
  • 78.05 (n)
lizard
(Anolis carolinensis)
Reptilia DGKZ 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dgkz 34
  • 69.66 (n)
zebrafish
(Danio rerio)
Actinopterygii dgkza 34 35
  • 65.92 (n)
dgkzb 35
  • 61 (a)
OneToMany
Dr.11340 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000519 34
  • 58.55 (n)
fruit fly
(Drosophila melanogaster)
Insecta rdgA 36 34 35
  • 53.04 (n)
worm
(Caenorhabditis elegans)
Secernentea dgk-5 34 35
  • 47.98 (n)
K06A1.6 36
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
OneToMany
Species where no ortholog for DGKZ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DGKZ Gene

ENSEMBL:
Gene Tree for DGKZ (if available)
TreeFam:
Gene Tree for DGKZ (if available)

Paralogs for DGKZ Gene

Paralogs for DGKZ Gene

Pseudogenes.org Pseudogenes for DGKZ Gene

genes like me logo Genes that share paralogs with DGKZ: view

Variants for DGKZ Gene

Sequence variations from dbSNP and Humsavar for DGKZ Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs869312943 Likely pathogenic 46,372,813(+) TGAAG(C/T)CGCCA nc-transcript-variant, reference, missense
rs1000002643 -- 46,380,726(+) GCGCT(A/C)GTCGG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1000018838 -- 46,342,300(+) TGACA(C/T)TGACA intron-variant
rs1000059396 -- 46,375,070(+) ATGGT(G/T)CCTGG intron-variant, upstream-variant-2KB
rs1000097772 -- 46,351,619(+) AACCT(C/G)TTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DGKZ Gene

Variant ID Type Subtype PubMed ID
esv3626183 CNV gain 21293372
esv3626185 CNV loss 21293372
nsv309 CNV deletion 18451855
nsv554201 CNV loss 21841781
nsv554202 CNV loss 21841781
nsv554203 CNV loss 21841781
nsv825867 CNV gain 20364138
nsv951610 CNV deletion 24416366

Variation tolerance for DGKZ Gene

Residual Variation Intolerance Score: 79.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.25; 92.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DGKZ Gene

Human Gene Mutation Database (HGMD)
DGKZ
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DGKZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGKZ Gene

Disorders for DGKZ Gene

Relevant External Links for DGKZ

Genetic Association Database (GAD)
DGKZ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DGKZ

No disorders were found for DGKZ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DGKZ Gene

Publications for DGKZ Gene

  1. Molecular cloning and characterization of a novel human diacylglycerol kinase zeta. (PMID: 8626588) Bunting M. … Prescott S.M. (J. Biol. Chem. 1996) 2 3 4 22 64
  2. Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling. (PMID: 17351151) Rincon E. … Merida I. (Mol. Cell. Proteomics 2007) 3 4 22 64
  3. Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism. (PMID: 11257115) Topham M.K. … Prescott S.M. (J. Cell Biol. 2001) 3 4 22 64
  4. Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions. (PMID: 11352924) Hogan A. … Gee S.H. (J. Biol. Chem. 2001) 3 4 22 64
  5. Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta. (PMID: 9716136) Topham M.K. … Prescott S.M. (Nature 1998) 3 4 22 64

Products for DGKZ Gene