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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DGKQ Gene

protein-coding   GIFtS: 65
GCID: GC04M000942

Diacylglycerol Kinase, Theta 110kDa

(Previous names: diacylglycerol kinase, theta (110kD))
(Previous symbol: DAGK4)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Diacylglycerol Kinase, Theta 110kDa1 2     EC 2.7.1.1073 8
DAGK41 2 3 5     Diacylglycerol Kinase, Theta (110kD)1
Diglyceride Kinase Theta2 3     DAGK2
DGK-theta2 3     DAGK72
DAG Kinase Theta2 3     Diacylglycerol Kinase Theta2

External Ids:    HGNC: 28561   Entrez Gene: 16092   Ensembl: ENSG000001452147   OMIM: 6012075   UniProtKB: P528243   

Export aliases for DGKQ gene to outside databases

Previous GC identifers: GC04M000959 GC04P000832 GC04M000944


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DGKQ Gene:
The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin
homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the
nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during
cell signal transduction. (provided by RefSeq, Jul 2008)

GeneCards Summary for DGKQ Gene: 
DGKQ (diacylglycerol kinase, theta 110kDa) is a protein-coding gene. Diseases associated with DGKQ include hypertrophic scars, and aggressive periodontitis, and among its related super-pathways are Signaling by GPCR and Gastrin-CREB signalling pathway via PKC and MAPK. GO annotations related to this gene include diacylglycerol kinase activity and kinase binding. An important paralog of this gene is DGKH.

UniProtKB/Swiss-Prot: DGKQ_HUMAN, P52824
Function: Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of
protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in
response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP-induced activation of
NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically
with NR5A1 on CYP17 transcriptional activity

summary for DGKQ Gene:
Diacylglycerol kinases (DGKs) are a group of ten enzymes (DGKalpha, DGKbeta, DGKgamma, DGKdelta, DGKepsilon,
DGKzeta, DGKeta, DGKtheta, DGKiota and DGKkappa) that metabolize 1,2,diacylglycerol (DAG) to produce
phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain, two cysteine-rich
Zn2+-finger motifs that bind DAG and an ATP-binding site, whilst the regulatory domain varies. DGKs are
widely distributed throughout mammalian tissues and different isozymes have different subcellular
localizations; some are cytosolic (for example DGKalpha), some are membrane-bound (for example DGKgamma is
associated with the Golgi membrane) and some are nuclear (for example DGKzeta. DGKs have diverse biological
roles as they participate in signal transduction by modulating levels of DAG in a variety of cellular
responses to extracellular stimuli.

Gene Wiki entry for DGKQ Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_037622.5  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DGKQ gene promoter:
         PPAR-gamma1   USF1   p53   USF-1   PPAR-gamma2   POU3F2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for DGKQ

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DGKQ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

DGKQ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DGKQ gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M000942:  view genomic region     (about GC identifiers)

Start:
952,675 bp from pter      End:
980,683 bp from pter
Size:
28,009 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DGKQ_HUMAN, P52824 (See protein sequence)
Recommended Name: Diacylglycerol kinase theta  
Size: 942 amino acids; 101155 Da
Subunit: Interacts with RHOA (constitutively activated, GTP-bound); the interaction inhibits DGKQ. Interacts with
PRKCE. Interacts with PRKCH. Interacts with PLCB1. Interacts with NR5A1; the interaction requires the LXXLL motif
1 and LXXLL motif 2 in DGKQ
Subcellular location: Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton. Nucleus. Nucleus speckle.
Note=Translocates to the nucleus in response to thrombin stimulation (By similarity). Translocates to the plasma
membrane in response to steroid hormone receptor stimulation. Translocation to the plasma membrane is dependent
on G-protein coupled receptor stimulation and subsequent activation of PRKCE and probably PRKCH
Secondary accessions: Q6P3W4

Explore the universe of human proteins at neXtProt for DGKQ: NX_P52824

Explore proteomics data for DGKQ at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by PRKCE and PRKCH in vitro
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P52824

  • 4 DME Specific Peptides for DGKQ (P52824)
     VNPKSGG  PVQVDGE  PLGTGNDL  CGGDGTVGW 

    DGKQ Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DGKQ Protein Expression
    REFSEQ proteins: NP_001338.2  
    ENSEMBL proteins: 
     ENSP00000273814   ENSP00000425862   ENSP00000421756   ENSP00000427268  
    Reactome Protein details: P52824
    Human Recombinant Protein Products for DGKQ: 
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    Novus Biologicals DGKQ Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15632189
    GO:0005737cytoplasm IDA15632189
    GO:0005829cytosol IDA10066731
    GO:0005856cytoskeleton IDA10066731
    GO:0005886plasma membrane TAS--

    DGKQ for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR001206 Diacylglycerol_kinase_cat_dom
     IPR000756 Diacylglycerol_kin_accessory
     IPR000159 Ras-assoc
     IPR002219 Prot_Kinase_C-like_PE/DAG-bd

    Graphical View of Domain Structure for InterPro Entry P52824

    ProtoNet protein and cluster: P52824

    2 Blocks protein domains:
    IPB000159 RA domain
    IPB000756 Diacylglycerol kinase accessory domain (presumed)


    UniProtKB/Swiss-Prot: DGKQ_HUMAN, P52824
    Domain: The L-X-X-L-L repeats are implicated in binding to the nuclear receptor NR5A1
    Similarity: Belongs to the eukaryotic diacylglycerol kinase family
    Similarity: Contains 1 DAGKc domain
    Similarity: Contains 3 phorbol-ester/DAG-type zinc fingers
    Similarity: Contains 1 Ras-associating domain


    DGKQ for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DGKQ_HUMAN, P52824
    Function: Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of
    protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in
    response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP-induced activation of
    NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically
    with NR5A1 on CYP17 transcriptional activity
    Catalytic activity: ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate
    Enzyme regulation: Inactivated by binding to RHOA. Not inhibited by phosphatidylserine

         Genatlas biochemistry entry for DGKQ:
    diacylglycerol kinase,110kDa,expressed in retina

         Enzyme Number (IUBMB): EC 2.7.1.1071 2

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003951NAD+ kinase activity IEA--
    GO:0004143diacylglycerol kinase activity IDA10066731
    GO:0005515protein binding IPI10066731
    GO:0005524ATP binding IEA--
    GO:0019900kinase binding IPI15632189
         
    DGKQ for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DGKQ:
     Decreased 12E8 and total tau p  Increased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DGKQ 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DGKQ About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    2G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    3Platelet activation, signaling and aggregation
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    4Glycerophospholipid biosynthesis
    Glycerophospholipid metabolism0.62
    5Inositol phosphate metabolism
    Phosphatidylinositol signaling system0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/8        Reactome Pathways for DGKQ (see all 8)
        GPCR downstream signaling
    Hemostasis
    Effects of PIP2 hydrolysis
    Signal Transduction
    Gastrin-CREB signalling pathway via PKC and MAPK


    4         Kegg Pathways  (Kegg details for DGKQ):
        Glycerolipid metabolism
    Glycerophospholipid metabolism
    Metabolic pathways
    Phosphatidylinositol signaling system


    DGKQ for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DGKQ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/39 Interacting proteins for DGKQ (P528243 ENSP000002738144) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOAP615863, ENSP000004001754I2D: score=2 STRING: ENSP00000400175
    KDM5BQ9UGL13, ENSP000003562344I2D: score=1 STRING: ENSP00000356234
    AGPAT2ENSP000003607614STRING: ENSP00000360761
    DGAT1ENSP000003322584STRING: ENSP00000332258
    ENSG00000228892ENSP000004128054STRING: ENSP00000412805
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007186G-protein coupled receptor signaling pathway IMP15632189
    GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway IEA--
    GO:0007596blood coagulation TAS--
    GO:0019933cAMP-mediated signaling IDA17664281

    DGKQ for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DGKQ for compounds           About GeneDecksing

    EMD Millipore small molecules for DGKQ:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for DGKQ available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DioctanoylglycolDiacylglycerol kinase inhibitor[627-86-1]

    10/862 HMDB Compounds for DGKQ (see all 862)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----

    10/55 Novoseek inferred chemical compound relationships for DGKQ gene (see all 55)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dioctanoyl ethylene glycol 85 1 1601860 (1)
    ceramide 1-phosphate 79.7 4 17440345 (1), 9207084 (1), 12927832 (1)
    phosphatidate 76.6 5 9129148 (1), 10052864 (1), 8392346 (1), 9572571 (1)
    phosphatidylinositol phosphate 75 4 1655800 (1), 7928021 (1), 11328964 (1), 19638643 (1)
    dioctanoylglycerol 74.2 3 15537648 (1), 10428791 (1)
    ceramide 73.9 39 12927832 (2), 7663417 (2), 9821861 (1), 10348816 (1) (see all 26)
    sphingosine 72.1 10 16520486 (2), 17351295 (1), 7548113 (1), 7548112 (1) (see all 8)
    rhc 80267 67.3 2 11535132 (1), 15196975 (1)
    1,2-dioctanoyl-sn-glycerol 65.4 1 18755689 (1)
    chapso 63.7 1 10964416 (1)

    Search CenterWatch for drugs/clinical trials and news about DGKQ

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DGKQ gene: 
    NM_001347.3  

    Unigene Cluster for DGKQ:

    Diacylglycerol kinase, theta 110kDa
    Hs.584858  [show with all ESTs]
    Unigene Representative Sequence: BC063801
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273814(uc003gbw.3 uc010ibn.3) ENST00000509465 ENST00000515182
    ENST00000502309 ENST00000510286

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    Additional mRNA sequence: 

    AB209503.1 BC063801.1 GU727647.1 L38707.1 

    3 DOTS entries:

    DT.92424713  DT.111503  DT.40119878 

    24/86 AceView cDNA sequences (see all 86):

    AI961689 CB216586 NM_001347 AI739088 AI125148 AW205803 AW207660 BI062760 
    BX346347 AW087258 AI274347 BQ003465 BI062693 AL536689 AI431413 BI062904 
    AI475892 BM970249 BI063128 CD108875 BI062894 BI063124 BX451758 BI758032 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DGKQ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACGTGGAGG
    DGKQ Expression
    About this image


    See DGKQ Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DGKQ

    SOURCE GeneReport for Unigene cluster: Hs.584858
        SABiosciences Custom PCR Arrays for DGKQ
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGKQ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DGKQ gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dgkq1 , 5 diacylglycerol kinase, theta1, 5 80.8(n)1
    82.24(a)1
      5 (53.24 cM)5
    1105241  NM_199011.11  NP_950176.11 
     1086466935 
    chicken
    (Gallus gallus)
    Aves DGKQ1 diacylglycerol kinase, theta 110kDa 66.22(n)
    67.85(a)
      427381  XM_424953.3  XP_424953.3 
    lizard
    (Anolis carolinensis)
    Reptilia DGKQ6
    diacylglycerol kinase, theta 110kDa
    61(a)
    1 ↔ 1
    GL343201.1(1047143-1113428)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG311406
    CG343846
    --
    24(a)
    10(a)
    1 ↔ 1
    possible ortholog
    3R(19788902-19808954)
    3R(3640083-3680507)
    worm
    (Caenorhabditis elegans)
    Secernentea dgk-13 diacylglycerol kinase 37(a)   X(1019941-1026541)   --
    barley
    (Hordeum vulgare)
    Liliopsida Hv.112512 Transcribed sequence with weak similarity to protein more 77.05(n)    BI952642.1 


    ENSEMBL Gene Tree for DGKQ (if available)
    TreeFam Gene Tree for DGKQ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DGKQ gene
    DGKH2  DGKB2  DGKI2  DGKE2  DGKZ2  DGKA2  DGKG2  DGKD2  
    1 SIMAP similar gene for DGKQ using alignment to 4 protein entries:     DGKQ_HUMAN (see all proteins):
    DGKE

    DGKQ for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/567 SNPs in DGKQ are shown (see all 567)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1156579871,2
    C,F--952954(+) AATGCG/ATGTGT 1 -- ut311Minor allele frequency- A:0.02NA 120
    rs1916164911,2
    --953012(+) GGGCCC/TCCCAG 1 -- ut310--------
    rs117373631,2
    H--953158(+) TCCGCA/CCCGTG 1 -- ut31 ese30--------
    rs349317381,2
    C,F--953194(+) GGCTTC/-CCCAC 1 -- ut313Minor allele frequency- -:0.33NA CSA 6
    rs1130673571,2
    C--953194(+) GGCTTC/TCCCAC 1 -- ut311Minor allele frequency- T:0.50CSA 2
    rs744725321,2
    C,F--953250(+) CCATCT/CGAATC 1 -- ut312Minor allele frequency- C:0.03WA NA 238
    rs1482759021,2
    --953382(+) CACACA/GCTGAC 1 -- ut310--------
    rs750676981,2
    C,F--953459(+) GCAGCG/ATGGAA 1 -- ut312Minor allele frequency- A:0.07NA EA 240
    rs732118031,2
    --953476(+) AGCGTA/GGGGTC 1 -- ut310--------
    rs1143395351,2
    F--953489(+) GGGCTG/AAAAGC 1 -- ut311Minor allele frequency- A:0.02NA 120

    HapMap Linkage Disequilibrium report for DGKQ (952675 - 980683 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/17 variations for DGKQ (see all 17):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2726741CNV Deletion23290073
    dgv5397n71CNV Loss21882294
    dgv5396n71CNV Loss21882294
    nsv469998CNV Loss18288195
    dgv5390n71CNV Loss21882294
    esv28042CNV Loss19812545
    nsv878292CNV Loss21882294
    nsv878287CNV Loss21882294
    dgv5391n71CNV Loss21882294
    dgv5395n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DGKQ
    DNA2.0 Custom Variant and Variant Library Synthesis for DGKQ

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601207    OMIM disorders: --

    20 diseases for DGKQ:    About MalaCards
    hypertrophic scars    aggressive periodontitis    optic atrophy    retinal degeneration
    keloids    pertussis    epididymitis    periodontitis
    retinitis    parkinson's disease    retinoblastoma    hypoxia
    gastric cancer    hypertension    tuberculosis    endotheliitis
    neuronitis    pancreatitis    leukemia    breast cancer


    DGKQ for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    5 Novoseek inferred disease relationships for DGKQ gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinal degeneration 37.8 4 10071200 (1), 10798401 (1), 15755798 (1)
    tumors 3.89 2 19751727 (1), 15849745 (1)
    leukemia 0 1 1309777 (1)
    carcinoma squamous cell 0 1 9213428 (1)
    necrosis 0 1 19751727 (1)

    Genetic Association Database (GAD): DGKQ
    Human Genome Epidemiology (HuGE) Navigator: DGKQ (2 documents)

    Export disorders for DGKQ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DGKQ gene, integrated from 9 sources (see all 241):
    (articles sorted by number of sources associating them with DGKQ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. (PubMed id 9099683)1, 3, 9 Houssa B....van Blitterswijk W.J. (1997)
    2. Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C. (PubMed id 15632189)1, 2, 9 van Baal J.... van Blitterswijk W.J. (2005)
    3. Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus. (PubMed id 12799190)1, 2, 9 Tabellini G....Martelli A.M. (2003)
    4. Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA. (PubMed id 10066731)1, 2, 9 Houssa B....van Blitterswijk W.J. (1999)
    5. Meta-analysis of Parkinson's disease: identification o f a novel locus, RIT2. (PubMed id 22451204)1, 4 Pankratz N....Foroud T. (2012)
    6. Comprehensive research synopsis and systematic meta-an alyses in Parkinson's disease genetics: The PDGene database. (PubMed id 22438815)1, 4 Lill C.M....Bertram L. (2012)
    7. Genome-wide association study confirms SNPs in SNCA a nd the MAPT region as common risk factors for Parkinson disease. (PubMed id 20070850)1, 4 Edwards T.L....Martin E.R. (2010)
    8. Genomewide association study for susceptibility genes contributing to familial Parkinson disease. (PubMed id 18985386)1, 4 Pankratz N....Myers R.H. (2009)
    9. Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17. (PubMed id 17664281)1, 2 Li D.... Sewer M.B. (2007)
    10. Assignment of the human diacylglycerol kinase 4 (DAGK4) gene to chromosome 4p16.3. (PubMed id 8617502)1, 3 Endele S....Winterpacht A. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1609 HGNC: 2856 AceView: DGKQ Ensembl:ENSG00000145214 euGenes: HUgn1609
    ECgene: DGKQ Kegg: 1609 H-InvDB: DGKQ

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DGKQ Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DGKQ Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DGKQ gene:
    Search GeneIP for patents involving DGKQ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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