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Aliases for DGKQ Gene

Aliases for DGKQ Gene

  • Diacylglycerol Kinase Theta 2 3 5
  • Diacylglycerol Kinase, Theta 110kDa 2 3
  • Diglyceride Kinase Theta 3 4
  • DAG Kinase Theta 3 4
  • EC 2.7.1.107 4 63
  • DGK-Theta 3 4
  • DAGK4 3 4
  • Testis Tissue Sperm-Binding Protein Li 38a 3
  • Diacylglycerol Kinase, Theta (110kD) 2
  • DAGK7 3
  • DAGK 3

External Ids for DGKQ Gene

Previous HGNC Symbols for DGKQ Gene

  • DAGK4

Previous GeneCards Identifiers for DGKQ Gene

  • GC04M000959
  • GC04P000832
  • GC04M000944

Summaries for DGKQ Gene

Entrez Gene Summary for DGKQ Gene

  • The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]

GeneCards Summary for DGKQ Gene

DGKQ (Diacylglycerol Kinase Theta) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include kinase binding and phospholipase binding. An important paralog of this gene is DGKI.

UniProtKB/Swiss-Prot for DGKQ Gene

  • Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP-induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity.

Tocris Summary for DGKQ Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.

Gene Wiki entry for DGKQ Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGKQ Gene

Genomics for DGKQ Gene

Regulatory Elements for DGKQ Gene

Promoters for DGKQ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DGKQ on UCSC Golden Path with GeneCards custom track

Genomic Location for DGKQ Gene

Chromosome:
4
Start:
958,884 bp from pter
End:
986,895 bp from pter
Size:
28,012 bases
Orientation:
Minus strand

Genomic View for DGKQ Gene

Genes around DGKQ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGKQ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGKQ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKQ Gene

Proteins for DGKQ Gene

  • Protein details for DGKQ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52824-DGKQ_HUMAN
    Recommended name:
    Diacylglycerol kinase theta
    Protein Accession:
    P52824
    Secondary Accessions:
    • Q6P3W4

    Protein attributes for DGKQ Gene

    Size:
    942 amino acids
    Molecular mass:
    101155 Da
    Quaternary structure:
    • Interacts with RHOA (constitutively activated, GTP-bound); the interaction inhibits DGKQ. Interacts with PRKCE. Interacts with PRKCH. Interacts with PLCB1. Interacts with NR5A1; the interaction requires the LXXLL motif 1 and LXXLL motif 2 in DGKQ.

neXtProt entry for DGKQ Gene

Proteomics data for DGKQ Gene at MOPED

Selected DME Specific Peptides for DGKQ Gene

Post-translational modifications for DGKQ Gene

Other Protein References for DGKQ Gene

Antibody Products

Domains & Families for DGKQ Gene

Gene Families for DGKQ Gene

Suggested Antigen Peptide Sequences for DGKQ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52824

UniProtKB/Swiss-Prot:

DGKQ_HUMAN :
  • The L-X-X-L-L repeats are implicated in binding to the nuclear receptor NR5A1.
  • Belongs to the eukaryotic diacylglycerol kinase family.
  • Contains 3 phorbol-ester/DAG-type zinc fingers.
Domain:
  • The L-X-X-L-L repeats are implicated in binding to the nuclear receptor NR5A1.
  • Contains 1 DAGKc domain.
  • Contains 1 Ras-associating domain.
Family:
  • Belongs to the eukaryotic diacylglycerol kinase family.
Similarity:
  • Contains 3 phorbol-ester/DAG-type zinc fingers.
genes like me logo Genes that share domains with DGKQ: view

Function for DGKQ Gene

Molecular function for DGKQ Gene

GENATLAS Biochemistry:
diacylglycerol kinase,110kDa,expressed in retina
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inactivated by binding to RHOA. Not inhibited by phosphatidylserine.
UniProtKB/Swiss-Prot Function:
Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP-induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity.

Enzyme Numbers (IUBMB) for DGKQ Gene

Gene Ontology (GO) - Molecular Function for DGKQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10066731
GO:0005524 ATP binding IEA --
GO:0019900 kinase binding IPI 15632189
genes like me logo Genes that share ontologies with DGKQ: view
genes like me logo Genes that share phenotypes with DGKQ: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DGKQ

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DGKQ Gene

Localization for DGKQ Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGKQ Gene

Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton. Nucleus. Nucleus speckle. Note=Translocates to the nucleus in response to thrombin stimulation (PubMed:15632189). Translocates to the plasma membrane in response to steroid hormone receptor stimulation (PubMed:15632189). Translocation to the plasma membrane is dependent on G-protein coupled receptor stimulation and subsequent activation of PRKCE and probably PRKCH (PubMed:15632189).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DGKQ Gene COMPARTMENTS Subcellular localization image for DGKQ gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for DGKQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 15632189
genes like me logo Genes that share ontologies with DGKQ: view

Pathways & Interactions for DGKQ Gene

genes like me logo Genes that share pathways with DGKQ: view

Gene Ontology (GO) - Biological Process for DGKQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IMP 15632189
GO:0019933 cAMP-mediated signaling IDA 17664281
GO:0070528 protein kinase C signaling IDA 15632189
genes like me logo Genes that share ontologies with DGKQ: view

No data available for SIGNOR curated interactions for DGKQ Gene

Drugs & Compounds for DGKQ Gene

(22) Drugs for DGKQ Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(58) Additional Compounds for DGKQ Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(2) Tocris Compounds for DGKQ Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor 627-86-1
R 59-022 Diacylglycerol kinase inhibitor; increases PKC activity 93076-89-2
genes like me logo Genes that share compounds with DGKQ: view

Transcripts for DGKQ Gene

Unigene Clusters for DGKQ Gene

Diacylglycerol kinase, theta 110kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DGKQ Gene

No ASD Table

Relevant External Links for DGKQ Gene

GeneLoc Exon Structure for
DGKQ
ECgene alternative splicing isoforms for
DGKQ

Expression for DGKQ Gene

mRNA expression in normal human tissues for DGKQ Gene

Protein differential expression in normal tissues from HIPED for DGKQ Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.8), CD8 Tcells (15.5), Frontal cortex (11.5), and Serum (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DGKQ Gene



SOURCE GeneReport for Unigene cluster for DGKQ Gene Hs.584858

genes like me logo Genes that share expression patterns with DGKQ: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DGKQ Gene

Orthologs for DGKQ Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DGKQ Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DGKQ 35
  • 83.33 (n)
  • 82.05 (a)
DGKQ 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DGKQ 35
  • 83.61 (n)
  • 81.75 (a)
DGKQ 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dgkq 35
  • 80.57 (n)
  • 81.92 (a)
Dgkq 16
Dgkq 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DGKQ 35
  • 96.75 (n)
  • 96.23 (a)
rat
(Rattus norvegicus)
Mammalia Dgkq 35
  • 80.72 (n)
  • 81.37 (a)
oppossum
(Monodelphis domestica)
Mammalia DGKQ 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DGKQ 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves DGKQ 35
  • 66.37 (n)
  • 67.94 (a)
DGKQ 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DGKQ 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dgkq 35
  • 62.43 (n)
  • 64.42 (a)
zebrafish
(Danio rerio)
Actinopterygii DGKQ 36
  • 45 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004209 35
  • 51.23 (n)
  • 43.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31140 35
  • 54.09 (n)
  • 45.44 (a)
CG34384 36
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dgk-1 37
  • 37 (a)
dgk-1 35
  • 46.04 (n)
  • 40.85 (a)
dgk-4 36
  • 14 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.11251 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2680 36
  • 16 (a)
OneToMany
Species with no ortholog for DGKQ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DGKQ Gene

ENSEMBL:
Gene Tree for DGKQ (if available)
TreeFam:
Gene Tree for DGKQ (if available)

Paralogs for DGKQ Gene

Paralogs for DGKQ Gene

(1) SIMAP similar genes for DGKQ Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DGKQ: view

Variants for DGKQ Gene

Sequence variations from dbSNP and Humsavar for DGKQ Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs17855876 - 973,403(+) GCACG(A/G)GGCTG reference, missense
rs1377586 -- 967,585(-) CTCGT(C/T)ACGGT reference, synonymous-codon
rs1377587 -- 967,403(-) CCGCC(C/T)GACCC intron-variant
rs2305487 -- 967,609(-) GCGGT(A/C/G)AGAAG reference, synonymous-codon
rs2242082 -- 964,838(-) CAGGA(C/T)GCAGC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for DGKQ Gene

Variant ID Type Subtype PubMed ID
nsv822425 CNV Loss 20364138
dgv5390n71 CNV Loss 21882294
dgv5391n71 CNV Loss 21882294
nsv469998 CNV Loss 18288195
esv29984 CNV Loss 17803354
dgv5395n71 CNV Loss 21882294
nsv878286 CNV Gain 21882294
nsv878287 CNV Loss 21882294
dgv5396n71 CNV Loss 21882294
dgv5397n71 CNV Loss 21882294
nsv878292 CNV Loss 21882294
nsv4196 CNV Loss 18451855
esv28042 CNV Loss 19812545
nsv822428 CNV Gain 20364138
nsv878310 CNV Loss 21882294
dgv5398n71 CNV Loss 21882294
esv2726741 CNV Deletion 23290073

Variation tolerance for DGKQ Gene

Residual Variation Intolerance Score: 9.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.54; 72.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DGKQ Gene

HapMap Linkage Disequilibrium report
DGKQ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGKQ Gene

Disorders for DGKQ Gene

Relevant External Links for DGKQ

Genetic Association Database (GAD)
DGKQ
Human Genome Epidemiology (HuGE) Navigator
DGKQ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DGKQ

No disorders were found for DGKQ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DGKQ Gene

Publications for DGKQ Gene

  1. Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. (PMID: 9099683) Houssa B. … van Blitterswijk W.J. (J. Biol. Chem. 1997) 2 3 23 67
  2. Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C. (PMID: 15632189) van Baal J. … van Blitterswijk W.J. (J. Biol. Chem. 2005) 3 23
  3. Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus. (PMID: 12799190) Tabellini G. … Martelli A.M. (Exp. Cell Res. 2003) 3 23
  4. Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA. (PMID: 10066731) Houssa B. … van Blitterswijk W.J. (J. Biol. Chem. 1999) 3 23
  5. Molecules in focus: diacylglycerol kinase. (PMID: 9438377) Sakane F. … Kanoh H. (Int. J. Biochem. Cell Biol. 1997) 3 23

Products for DGKQ Gene

Sources for DGKQ Gene

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