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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DGKQ Gene

protein-coding   GIFtS: 62
GCID: GC04M000942

diacylglycerol kinase, theta 110kDa

(Previous names: diacylglycerol kinase, theta (110kD) )
(Previous symbol: DAGK4)
 Explore 22 diseases affiliated with
DGKQ via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DGKQ    

Aliases
for DGKQ gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Diacylglycerol Kinase, Theta 110kDa1 2     DGK-Theta1
DAGK41 2 3 5     DAG Kinase Theta2 3
DAGK1 2     EC 2.7.1.1073 8
DAGK71 2     Diacylglycerol Kinase, Theta (110kD)1
Diglyceride Kinase Theta2 3     Diacylglycerol Kinase Theta2

External Ids:    HGNC: 28561   Entrez Gene: 16092   Ensembl: ENSG000001452147   OMIM: 6012075   UniProtKB: P528243   

Export aliases for DGKQ gene to outside databases

Previous GC identifers: GC04M000959 GC04P000832 GC04M000944


Summaries
for DGKQ gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DGKQ:
The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology
domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates
the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DGKQ_HUMAN, P52824
Function: Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein
kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to
alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP-induced activation of NR5A1 and
subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on
CYP17 transcriptional activity

summary for DGKQ:
Diacylglycerol kinases (DGKs) are a group of ten enzymes (DGKalpha, DGKbeta, DGKgamma, DGKdelta, DGKepsilon,
DGKzeta, DGKeta, DGKtheta, DGKiota and DGKkappa) that metabolize 1,2,diacylglycerol (DAG) to produce
phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain, two cysteine-rich
Zn2+-finger motifs that bind DAG and an ATP-binding site, whilst the regulatory domain varies. DGKs are
widely distributed throughout mammalian tissues and different isozymes have different subcellular
localizations; some are cytosolic (for example DGKalpha), some are membrane-bound (for example DGKgamma is
associated with the Golgi membrane) and some are nuclear (for example DGKzeta. DGKs have diverse biological
roles as they participate in signal transduction by modulating levels of DAG in a variety of cellular
responses to extracellular stimuli.

Gene Wiki entry for DGKQ


Genomic Views
for DGKQ gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_037622.5  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DGKQ gene promoter:
         PPAR-gamma1   USF1   p53   USF-1   PPAR-gamma2   POU3F2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for DGKQ

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DGKQ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

DGKQ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DGKQ gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M000942:  view genomic region     (about GC identifiers)

Start:
 952,675 bp from pter      End:
 980,683 bp from pter
Size:
 28,009 bases      Orientation:
 minus strand

Proteins
for DGKQ gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DGKQ_HUMAN, P52824 (See protein sequence)
Recommended Name: Diacylglycerol kinase theta  
Size: 942 amino acids; 101155 Da
Subunit: Interacts with RHOA (constitutively activated, GTP-bound); the interaction inhibits DGKQ. Interacts with
PRKCE. Interacts with PRKCH. Interacts with PLCB1. Interacts with NR5A1; the interaction requires the LXXLL motif 1
and LXXLL motif 2 in DGKQ
Subcellular location: Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton. Nucleus. Nucleus speckle. Note=Translocates to
the nucleus in response to thrombin stimulation (By similarity). Translocates to the plasma membrane in response to
steroid hormone receptor stimulation. Translocation to the plasma membrane is dependent on G-protein coupled receptor
stimulation and subsequent activation of PRKCE and probably PRKCH
Secondary accessions: Q6P3W4

Explore the universe of human proteins at neXtProt for DGKQ: NX_P52824

Post-translational modifications:

  • Phosphorylated by PRKCE and PRKCH in vitro1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P52824

    • 4 DME Specific Peptides for DGKQ (P52824)
     VNPKSGG  PVQVDGE  PLGTGNDL  CGGDGTVGW 

    DGKQ Protein expression data from MOPED and PaxDb:    About this image 
    DGKQ Protein Expression
    REFSEQ proteins: NP_001338.2  
    ENSEMBL proteins: 
     ENSP00000273814   ENSP00000425862   ENSP00000421756   ENSP00000427268  
    Reactome Protein details: P52824
    Human Recombinant Protein Products for DGKQ: 
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    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA17664281
    GO:0005737cytoplasm IDA15632189
    GO:0005829cytosol IDA10066731
    GO:0005856cytoskeleton IDA10066731

    DGKQ for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for DGKQ gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DGKQ for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001206 Diacylglycerol_kinase_cat_dom
     IPR002219 Prot_Kinase_C-like_PE/DAG-bd
     IPR000756 Diacylglycerol_kin_accessory
     IPR000159 Ras-assoc

    Graphical View of Domain Structure for InterPro Entry P52824

    ProtoNet protein and cluster: P52824

    2 Blocks protein families:
    IPB000159 RA domain
    IPB000756 Diacylglycerol kinase accessory domain (presumed)


    UniProtKB/Swiss-Prot: DGKQ_HUMAN, P52824
    Domain: The L-X-X-L-L repeats are implicated in binding to the nuclear receptor NR5A1
    Similarity: Belongs to the eukaryotic diacylglycerol kinase family
    Similarity: Contains 1 DAGKc domain
    Similarity: Contains 3 phorbol-ester/DAG-type zinc fingers
    Similarity: Contains 1 Ras-associating domain


    Function
    for DGKQ gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DGKQ_HUMAN, P52824
    Function: Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein
    kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to
    alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP-induced activation of NR5A1 and
    subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on
    CYP17 transcriptional activity
    Catalytic activity: ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate
    Enzyme regulation: Inactivated by binding to RHOA. Not inhibited by phosphatidylserine

         Genatlas biochemistry entry for DGKQ:
    diacylglycerol kinase,110kDa,expressed in retina

         Enzyme Number (IUBMB): EC 2.7.1.1071 2

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004143diacylglycerol kinase activity IDA10066731
    GO:0005515protein binding IPI10066731
    GO:0005524ATP binding IEA--
    GO:0019900kinase binding IPI15632189
    GO:0033613activating transcription factor binding IPI17664281
         
    DGKQ for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DGKQ:
     Decreased 12E8 and total tau p  Increased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DGKQ 

    miRNA
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    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Pathways & Interactions
    for DGKQ gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    2Platelet activation, signaling and aggregation
    		Platelet activation, signaling and aggregation1.00
    		Hemostasis0.43
    3G alpha (q) signalling events
    		G alpha (q) signalling events1.00
    		Gastrin-CREB signalling pathway via PKC and MAPK0.90
    4Effects of PIP2 hydrolysis
    		Effects of PIP2 hydrolysis1.00
    5Glycerolipid metabolism
    		Glycerolipid metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/8        Reactome Pathways for DGKQ (see all 8)
        GPCR downstream signaling
    Hemostasis
    Effects of PIP2 hydrolysis
    Signal Transduction
    Gastrin-CREB signalling pathway via PKC and MAPK


    4         Kegg Pathways  (Kegg details for DGKQ):
        Glycerolipid metabolism
    Glycerophospholipid metabolism
    Metabolic pathways
    Phosphatidylinositol signaling system


    DGKQ for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DGKQ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/39 Interacting proteins for DGKQ (P528243 ENSP000002738144) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOAP615863, ENSP000004001754I2D: score=2 STRING: ENSP00000400175
    KDM5BQ9UGL13, ENSP000003562344I2D: score=1 STRING: ENSP00000356234
    AGPAT2ENSP000003607614STRING: ENSP00000360761
    DGAT1ENSP000003322584STRING: ENSP00000332258
    PLCB4ENSP000003341054STRING: ENSP00000334105
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway IMP15632189
    GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway IEA--
    GO:0007596blood coagulation TAS--
    GO:0019933cAMP-mediated signaling IDA17664281
    GO:0030168platelet activation TAS--

    DGKQ for ontologies           About GeneDecksing



    Drugs & Compounds
    for DGKQ gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DGKQ for compounds           About GeneDecksing

    EMD Millipore small molecules for DGKQ:
    Small Molecule - inhibitor
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    Compounds for DGKQ available from Tocris Bioscience    About this table
    CompoundAction CAS #
    R 59-022Diacylglycerol kinase inhibitor; increases PKC activity[93076-89-2]
    DioctanoylglycolDiacylglycerol kinase inhibitor[627-86-1]

    10/862 HMDB Compounds for DGKQ (see all 862)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    10/55 Novoseek chemical compound relationships for DGKQ gene (see all 55)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dioctanoyl ethylene glycol 85 1 1601860 (1)
    ceramide 1-phosphate 79.7 4 17440345 (1), 9207084 (1), 12927832 (1)
    phosphatidate 76.6 5 9129148 (1), 10052864 (1), 8392346 (1), 9572571 (1)
    phosphatidylinositol phosphate 75 4 1655800 (1), 7928021 (1), 11328964 (1), 19638643 (1)
    dioctanoylglycerol 74.2 3 15537648 (1), 10428791 (1)
    ceramide 73.9 39 12927832 (2), 7663417 (2), 9821861 (1), 10348816 (1) (see all 26)
    sphingosine 72.1 10 16520486 (2), 17351295 (1), 7548113 (1), 7548112 (1) (see all 8)
    rhc 80267 67.3 2 11535132 (1), 15196975 (1)
    1,2-dioctanoyl-sn-glycerol 65.4 1 18755689 (1)
    chapso 63.7 1 10964416 (1)

    Search CenterWatch for drugs/clinical trials and news about DGKQ 

    Transcripts
    for DGKQ gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DGKQ gene: 
    NM_001347.3  

    Unigene Cluster for DGKQ:

    Diacylglycerol kinase, theta 110kDa
    Hs.584858  [show with all ESTs]
    Unigene Representative Sequence: BC063801
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273814(uc003gbw.3 uc010ibn.3) ENST00000509465 ENST00000515182
    ENST00000502309 ENST00000510286

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    Clone
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    Additional cDNA sequence: 

    AB209503.1 BC063801.1 GU727647.1 L38707.1 

    3 DOTS entries:

    DT.92424713  DT.111503  DT.40119878 

    24/86 AceView cDNA sequences (see all 86):

    AI125148 CB216586 AI961689 NM_001347 AI739088 AW207660 AW205803 BC063801 
    BI061390 BI061394 AI024392 BI062762 BI061607 BI062760 BI061608 BI061696 
    BI062904 AI475892 N54758 AI431413 BM970249 L38707 CB529109 BI062693 

    GeneLoc Exon Structure


    Expression
    for DGKQ gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DGKQ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CACGTGGAGG
    DGKQ Expression
    About this image
    See DGKQ Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DGKQ

    SOURCE GeneReport for Unigene cluster: Hs.584858
        SABiosciences Custom PCR Arrays for DGKQ

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    In Situ
    Assay Products:     
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    Orthologs
    for DGKQ gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DGKQ gene from 7/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dgkq1 , 5 diacylglycerol kinase, theta1, 5 80.8(n)1
    82.24(a)1    		   5 (53.24 cM)5
    1105241  NM_199011.11  NP_950176.11 
     1086466935 
    chicken
    (Gallus gallus)    		 Aves DGKQ1 diacylglycerol kinase, theta 110kDa 66.22(n)
    67.85(a)    		   427381  XM_424953.3  XP_424953.3 
    lizard
    (Anolis carolinensis)    		 Reptilia DGKQ6
    		 --
    		 65(a)
    		 1 ↔ 1
    		 GL343201.1(1073420-1113523)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG311406
    		 --
    		 21(a)
    		 1 ↔ 1
    		 3R(19788902-19808954)
    worm
    (Caenorhabditis elegans)    		 Secernentea dgk-13 diacylglycerol kinase 37(a)   X(1019941-1026541)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons DGK26
    DGK16
    (see all 7)    		 diacylglycerol kinase1
    (see all 7)    		 25(a)
    23(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 5(25518641-25523621)
    5(2524778-2529330)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 8)    		 diacylglycerol kinase 1, putative, expressed
    (see all 8)    		 26(a)
    23(a)
    (see all 8)    		 many ↔ many
    many ↔ many
    (see all 8)    		 12(6728516-6733263)
    12(23790291-23795978)


    ENSEMBL Gene Tree for DGKQ (if available)
    TreeFam Gene Tree for DGKQ (if available) 

    Paralogs
    for DGKQ gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DGKQ gene
    DGKA2  DGKH2  DGKG2  DGKB2  DGKD2  DGKI2  DGKE2  DGKZ2  
    1 SIMAP similar gene for DGKQ using alignment to 4 protein entries:     DGKQ_HUMAN (see all proteins):
    DGKE

    DGKQ for paralogs           About GeneDecksing



    Genomic Variants
    for DGKQ gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/381 NCBI SNPs in DGKQ are shown (see all 381)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 4 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1891636761,2
    		C--952317(+) CTCACC/TAGAGA 2 -- ut31 ds50010--------
    rs1491705821,2
    		--952390(+) CTTGCA/GTGGCC 2 -- ds5001 ut310--------
    rs7484831,2
    		C,F,A,H--952409(+) TTTTCA/GTTGTG 2 -- ut31 ds500119Minor allele frequency- G:0.10NA EA MN NS 2254
    rs1920912811,2
    		--952463(+) TTTGCA/GGAGAG 2 -- int1 ds50010--------
    rs286127981,2
    		C--952539(+) GACACG/ATTGCC 2 -- int1 ds50013Minor allele frequency- A:0.04NA WA 122
    rs1450731521,2
    		--952559(+) TACCCA/GAGGGG 2 -- int1 ds50010--------
    rs730644771,2
    		C--952644(+) CCCTCG/AGTTGT 2 -- int1 ds50012Minor allele frequency- A:0.13WA 120
    rs754562091,2
    		C,F--952687(+) GTGACG/TCCCAG 2 -- ut31 int11Minor allele frequency- T:0.13WA 118
    rs1844006981,2
    		--952704(+) TTTGTC/TCTGGA 2 -- ut31 int10--------
    rs1891584941,2
    		--952800(+) ATACAA/GGACAA 2 -- ut31 int10--------

    HapMap Linkage Disequilibrium report for DGKQ (952675 - 980683 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for DGKQ
         4 CNVs: 30190 30187 30189 30188
         1 Indel: 68595

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for DGKQ

    Disorders / Diseases
    for DGKQ gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DGKQ for disorders           About GeneDecksing

    OMIM gene information: 601207    OMIM disorders: --

    20/22 diseases for DGKQ (see all 22):    About MalaCards
    retinal degeneration    optic atrophy    aggressive periodontitis    glomerulosclerosis
    keloids    periodontitis    epididymitis    retinitis
    parkinson's disease    pertussis    gastric cancer    retinoblastoma
    breast cancer    hypertension    leukemia    cholesterol
    hypoxia    tuberculosis    carcinoma    pancreatitis

    5 Novoseek disease relationships for DGKQ gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinal degeneration 37.8 4 10071200 (1), 10798401 (1), 15755798 (1)
    tumors 3.89 2 19751727 (1), 15849745 (1)
    leukemia 0 1 1309777 (1)
    carcinoma squamous cell 0 1 9213428 (1)
    necrosis 0 1 19751727 (1)

    Human Genome Epidemiology (HuGE) Navigator: DGKQ (2 documents)

    Export disorders for DGKQ gene to outside databases

    Publications
    for DGKQ gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DGKQ gene, integrated from 9 sources (see all 240):
    (articles sorted by number of sources associating them with DGKQ)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. (PubMed id 9099683)1, 3, 9 Houssa B....van Blitterswijk W.J. (1997)
    2. Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C. (PubMed id 15632189)1, 2, 9 van Baal J.... van Blitterswijk W.J. (2005)
    3. Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus. (PubMed id 12799190)1, 2, 9 Tabellini G....Martelli A.M. (2003)
    4. Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA. (PubMed id 10066731)1, 2, 9 Houssa B....van Blitterswijk W.J. (1999)
    5. Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17. (PubMed id 17664281)1, 2 Li D.... Sewer M.B. (2007)
    6. Assignment of the human diacylglycerol kinase 4 (DAGK4) gene to chromosome 4p16.3. (PubMed id 8617502)1, 3 Endele S....Winterpacht A. (1996)
    7. Molecules in focus: diacylglycerol kinase. (PubMed id 9438377)1, 9 Sakane F. and Kanoh H. (1997)
    8. Structure-activity relationship of diacylglycerol kinase theta. (PubMed id 15164764)2, 9 Los A.P.... van Blitterswijk W.J. (2004)
    9. Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases. (PubMed id 8626538)1, 9 Sakane F.... Kanoh H. (1996)
    10. Meta-analysis of Parkinson's disease: identification o f a novel locus, RIT2. (PubMed id 22451204)1 Pankratz N....Foroud T. (2012)

    External Searches for DGKQ gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DGKQ gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1609 HGNC: 2856 AceView: DGKQ Ensembl:ENSG00000145214 euGenes: HUgn1609
    ECgene: DGKQ Kegg: 1609 H-InvDB: DGKQ

    Other Databases showing DGKQ gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DGKQ gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DGKQ Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DGKQ Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for DGKQ gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DGKQ gene:
    Search GeneIP for patents involving DGKQ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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