DGKK Gene
protein-coding GIFtS : 50
GCID: GC0X M050128
diacylglycerol kinase, kappa
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Aliasesfor DGKK gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Diacylglycerol Kinase, Kappa 1 2 DAG Kinase Kappa2 3 Diglyceride Kinase Kappa2 3 EC 2.7.1.1073 8 142 KDa Diacylglycerol Kinase2 3 Diacylglycerol Kinase Kappa2 DGK-Kappa1
Export aliases for DGKK gene to outside databases Previous GC identifers: GC0XM049944 GC0XM047555
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Summariesfor DGKK gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for DGKK : The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias. (provided by RefSeq, Mar 2011) UniProtKB/Swiss-Prot: DGKK_HUMAN, Q5KSL6 Function : Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA) summary
for DGKK : Diacylglycerol kinases (DGKs) are a group of ten enzymes (DGKalpha, DGKbeta, DGKgamma, DGKdelta, DGKepsilon,DGKzeta, DGKeta, DGKtheta, DGKiota and DGKkappa) that metabolize 1,2,diacylglycerol (DAG) to producephosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain, two cysteine-richZn2+-finger motifs that bind DAG and an ATP-binding site, whilst the regulatory domain varies. DGKs arewidely distributed throughout mammalian tissues and different isozymes have different subcellularlocalizations; some are cytosolic (for example DGKalpha), some are membrane-bound (for example DGKgamma isassociated with the Golgi membrane) and some are nuclear (for example DGKzeta. DGKs have diverse biologicalroles as they participate in signal transduction by modulating levels of DAG in a variety of cellularresponses to extracellular stimuli.
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Genomic Viewsfor DGKK gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000023.10 NC_018934.1 NT_011638.13 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the DGKK gene promoter: Nkx3-1 Nkx3-1 v4 Nkx3-1 v1 Evi-1 GATA-1 Nkx3-1 v2 Nkx3-1 v3 Cart-1 Other transcription factors Search SABiosciences Chromatin IP Primers for DGKK Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DGKK
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: Xp11.22 Ensembl cytogenetic band: Xp11.22 HGNC cytogenetic band: Xp11.22 DGKK Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XM050128: view genomic region
(about GC identifiers )
Start:
50,108,408 bp from pter
End:
50,213,737 bp from pter
Size:
105,330 bases
Orientation:
minus strand
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Proteinsfor DGKK gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
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Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
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GenScript ,
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Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: DGKK_HUMAN, Q5KSL6 (See
protein sequence )Recommended Name: Diacylglycerol kinase kappa Size : 1271 amino acids; 141829 Da
Subunit : Does not form homooligomers
Subcellular location : Cytoplasm. Membrane; Peripheral membrane protein
Secondary accessions : B2RP91Explore the universe of human proteins at neXtProt for DGKK: NX_Q5KSL6 Post-translational modifications:
Phosphorylated at Tyr-78 by some member of the SRC family in response to H(2)O(2)1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q5KSL6 4/5 DME Specific Peptides for DGKK (Q5KSL6 ) (see all 5 )DGKK Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_001013764.1 Reactome Protein details: Q5KSL6 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
DGKK for ontologies About GeneDecksing DGKK Antibody Products: Assay Products for DGKK:
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Protein
Domains / Familiesfor DGKK gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
DGKK for domains About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q5KSL6 ProtoNet protein and cluster: Q5KSL6
1 Blocks protein family : IPB000756 Diacylglycerol kinase accessory domain (presumed) UniProtKB/Swiss-Prot: DGKK_HUMAN, Q5KSL6 Similarity : Belongs to the eukaryotic diacylglycerol kinase familySimilarity : Contains 1 DAGKc domainSimilarity : Contains 1 PH domainSimilarity : Contains 2 phorbol-ester/DAG-type zinc fingers
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Functionfor DGKK gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
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siRNAs from
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QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
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SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: DGKK_HUMAN, Q5KSL6 Function : Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA)Catalytic activity : ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphateEnzyme regulation : Inhibited in response to H(2)O(2)Enzyme Number (IUBMB): EC 2.7.1.107 1 2
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DGKK (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DGKKOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: DGKK (NM_001013742 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DGKK Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DGKK
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGKK
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
DGKK for ontologies About GeneDecksing
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Pathways & Interactionsfor DGKK gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Signaling by GPCR 2 Platelet activation, signaling and aggregation 3 G alpha (q) signalling events 4 Effects of PIP2 hydrolysis
Pathway sources See GeneCards unified pathways Show all pathways 5/8
Reactome Pathways for DGKK (see all 8 )
DGKK for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DGKK Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6 ): About this table
DGKK for ontologies About GeneDecksing
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Drugs & Compoundsfor DGKK gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Compounds for DGKK available from Tocris Bioscience About this table Compound Action
CAS
# R 59-022 Diacylglycerol kinase inhibitor; increases PKC activity [93076-89-2] Dioctanoylglycol Diacylglycerol kinase inhibitor [627-86-1]
10/855 HMDB Compounds for DGKK (see all 855 ) About this table Search CenterWatch for drugs/clinical trials and news about DGKK
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Transcriptsfor DGKK gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
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)About This Section REFSEQ mRNAs for DGKK gene: NM_001013742.2 Unigene Cluster for DGKK:
Diacylglycerol kinase, kappa Hs.631770 [show with all ESTs ] Unigene Representative Sequence: NM_001013742 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000376025(lincRNA) (uc010njr.2 ) ENST00000546288(lincRNA) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DGKK (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DGKKOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: DGKK (NM_001013742 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DGKK Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DGKK
Additional cDNA sequence: AB183864.1 BC137319.1 BC137320.1
1 DOTS entry : DT.99968229
1 AceView cDNA sequence :
BQ924103 GeneLoc Exon Structure
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Expression for DGKK gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section DGKK expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AATAAGGAGT
About this image DGKK expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See DGKK Protein Expression from SPIRE MOPED and PaxDB SOURCE GeneReport for Unigene cluster: Hs.631770 UniProtKB/Swiss-Prot: DGKK_HUMAN, Q5KSL6 Tissue specificity : Expressed in testis, and to a lesser extent in placenta SABiosciences Custom PCR Arrays for DGKK Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DGKKBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat DGKK QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DGKK QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DGKK In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGKK
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Orthologsfor DGKK gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of human and mouse.
Orthologs for DGKK gene from 1/6 species (see all 6 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
mouse (Mus musculus)
Mammalia
Dgkk1 , 5
diacylglycerol kinase kappa1, 5
82.16(n) 1 77.84(a) 1
 
X (3.07 cM) 5 331374 1 NM_177914.3 1 NP_808582.3 1 6873484 5
ENSEMBL Gene Tree for DGKK (if available)TreeFam Gene Tree for DGKK (if available)
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Paralogsfor DGKK gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor DGKK gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr X pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for DGKK (50108408 - 50213737 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 6 variations for DGKK 2 CNVs : 83519 96679 4 Indels : 96680 83520 83521 96681
SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor DGKK gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
DGKK for disorders About GeneDecksing
OMIM gene information: 300837
OMIM disorders : --1 disease for DGKK : About MalaCards hypospadias Human Genome Epidemiology (HuGE) Navigator: DGKK (1 document)Export disorders for DGKK gene to outside databases
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Publicationsfor DGKK gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for DGKK gene integrated from 9 sources : (articles sorted by number of sources associating them with DGKK) Utopia : connect your pdf to the dynamic world of online information
Identification and characterization of a novel human type II diacylglycerol kinase, DGK kappa. (PubMed id 16210324) 1 , 2 , 3 Imai S.... Sakane F. (2005) Common variants in DGKK are strongly associated with risk of hypospadias. (PubMed id 21113153) 1 van der Zanden L.F....Knoers N.V. (2011) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 1 Barbe L....Andersson-Svahn H. (2008) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures. (PubMed id 12486725) 6 Kurz M....Kramer W. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for DGKK gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing DGKK gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing DGKK gene
(According to HUGE )
About This Section --
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Specialized Databases showing DGKK gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for DGKK Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for DGKK gene: Search GeneIP for patents involving DGKK GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor DGKK gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for DGKK OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for DGKK OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DGKK Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for DGKK Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DGKK OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DGKK Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for DGKK OriGene Custom Protein Services for DGKK OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DGKK Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DGKK QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DGKK QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat DGKK QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DGKK QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DGKK
Tocris compounds for DGKK
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGKK
ThermoFisher Antibodies for DGKK
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DGKK
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Aliases for DGKK
Databases for DGKK
Disorders / Diseases for DGKK
Domains / Families for DGKK
Drugs / Compounds for DGKK
Expression for DGKK
Function for DGKK
Genomic Views for DGKK
Intellectual Property for DGKK
Orthologs for DGKK
Paralogs for DGKK
Pathways / Interactions for DGKK
Products for DGKK
Proteins for DGKK
Publications for DGKK
Search Box for DGKK
Summaries for DGKK
Transcripts for DGKK
Variants for DGKK
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