Aliases for DGKK Gene
External Ids for DGKK Gene
Previous GeneCards Identifiers for DGKK Gene
The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias. [provided by RefSeq, Mar 2011]
GeneCards Summary for DGKK Gene
DGKK (Diacylglycerol Kinase Kappa) is a Protein Coding gene. Diseases associated with DGKK include Hypospadias. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include NAD+ kinase activity and diacylglycerol kinase activity. An important paralog of this gene is DGKD.
UniProtKB/Swiss-Prot for DGKK Gene
Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).
Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.