Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DGKK Gene

Aliases for DGKK Gene

  • Diacylglycerol Kinase, Kappa 2 3
  • 142 KDa Diacylglycerol Kinase 3 4
  • Diglyceride Kinase Kappa 3 4
  • DAG Kinase Kappa 3 4
  • EC 4 63
  • DGK-Kappa 3 4
  • Diacylglycerol Kinase Kappa 3

External Ids for DGKK Gene

Previous GeneCards Identifiers for DGKK Gene

  • GC0XM049944
  • GC0XM050128
  • GC0XM047555

Summaries for DGKK Gene

Entrez Gene Summary for DGKK Gene

  • The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias. [provided by RefSeq, Mar 2011]

GeneCards Summary for DGKK Gene

DGKK (Diacylglycerol Kinase, Kappa) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include phospholipid binding and diacylglycerol kinase activity.

UniProtKB/Swiss-Prot for DGKK Gene

  • Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).

Tocris Summary for DGKK Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes (DGKalpha, DGKbeta, DGKgamma, DGKdelta, DGKepsilon, DGKzeta, DGKeta, DGKtheta, DGKiota and DGKkappa) that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain, two cysteine-rich Zn2+-finger motifs that bind DAG and an ATP-binding site, whilst the regulatory domain varies. DGKs are widely distributed throughout mammalian tissues and different isozymes have different subcellular localizations; some are cytosolic (for example DGKalpha), some are membrane-bound (for example DGKgamma is associated with the Golgi membrane) and some are nuclear (for example DGKzeta. DGKs have diverse biological roles as they participate in signal transduction by modulating levels of DAG in a variety of cellular responses to extracellular stimuli.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGKK Gene

Genomics for DGKK Gene

Regulatory Elements for DGKK Gene

Genomic Location for DGKK Gene

50,365,409 bp from pter
50,470,738 bp from pter
105,330 bases
Minus strand

Genomic View for DGKK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DGKK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKK Gene

Proteins for DGKK Gene

  • Protein details for DGKK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Diacylglycerol kinase kappa
    Protein Accession:
    Secondary Accessions:
    • B2RP91

    Protein attributes for DGKK Gene

    1271 amino acids
    Molecular mass:
    141829 Da
    Quaternary structure:
    • Does not form homooligomers

neXtProt entry for DGKK Gene

Proteomics data for DGKK Gene at MOPED

Selected DME Specific Peptides for DGKK Gene

Post-translational modifications for DGKK Gene

  • Phosphorylated at Tyr-78 by some member of the SRC family in response to H(2)O(2).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DGKK Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for DGKK Gene

Suggested Antigen Peptide Sequences for DGKK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q5KSL6
  • Contains 1 DAGKc domain.
  • Contains 1 PH domain.
  • Belongs to the eukaryotic diacylglycerol kinase family.
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
genes like me logo Genes that share domains with DGKK: view

No data available for Gene Families for DGKK Gene

Function for DGKK Gene

Molecular function for DGKK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited in response to H(2)O(2).
UniProtKB/Swiss-Prot Function:
Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).

Enzyme Numbers (IUBMB) for DGKK Gene

Gene Ontology (GO) - Molecular Function for DGKK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003951 NAD+ kinase activity IEA --
GO:0004143 diacylglycerol kinase activity IDA 16210324
GO:0005524 ATP binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DGKK: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DGKK

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DGKK Gene

Localization for DGKK Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGKK Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Gene Ontology (GO) - Cellular Components for DGKK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with DGKK: view

No data available for Subcellular locations from COMPARTMENTS for DGKK Gene

Pathways for DGKK Gene

genes like me logo Genes that share pathways with DGKK: view

Interacting Proteins for DGKK Gene

Gene Ontology (GO) - Biological Process for DGKK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IDA 16210324
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0007596 blood coagulation TAS --
GO:0016310 phosphorylation IEA --
GO:0030168 platelet activation TAS --
genes like me logo Genes that share ontologies with DGKK: view

Compounds for DGKK Gene

(1) Tocris Compounds for DGKK Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor [627-86-1]

(855) HMDB Compounds for DGKK Gene

Compound Synonyms Cas Number PubMed IDs
  • DAG(14:0/14:0)
Not Available
  • DAG(14:0/14:1)
Not Available
  • Diacylglycerol(29:0)
Not Available
  • DAG(30:0)
Not Available
  • DG(30:1)
Not Available
genes like me logo Genes that share compounds with DGKK: view

Transcripts for DGKK Gene

mRNA/cDNA for DGKK Gene

(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DGKK Gene

Diacylglycerol kinase, kappa:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DGKK

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DGKK Gene

No ASD Table

Relevant External Links for DGKK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DGKK Gene

mRNA expression in normal human tissues for DGKK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DGKK Gene

This gene is overexpressed in Pituitary (17.4), Brain - Nucleus accumbens (basal ganglia) (16.3), Brain - Hypothalamus (6.4), and Brain - Putamen (basal ganglia) (4.4).

Protein differential expression in normal tissues for DGKK Gene

This gene is overexpressed in Kidney (27.0), Pancreas (22.8), and Lung (16.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for DGKK Gene

SOURCE GeneReport for Unigene cluster for DGKK Gene Hs.631770

mRNA Expression by UniProt/SwissProt for DGKK Gene

Tissue specificity: Expressed in testis, and to a lesser extent in placenta.
genes like me logo Genes that share expressions with DGKK: view

Expression partners for DGKK Gene

In Situ Assay Products

Orthologs for DGKK Gene

This gene was present in the common ancestor of chordates.

Orthologs for DGKK Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DGKK 35
  • 86.39 (n)
  • 84.03 (a)
(Canis familiaris)
Mammalia DGKK 35
  • 87.61 (n)
  • 84.43 (a)
(Mus musculus)
Mammalia Dgkk 35
  • 81.82 (n)
  • 77.64 (a)
Dgkk 16
(Pan troglodytes)
Mammalia DGKK 35
  • 99.65 (n)
  • 99.62 (a)
(Rattus norvegicus)
Mammalia Dgkk 35
  • 83.65 (n)
  • 79.43 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2361 35
Species with no ortholog for DGKK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DGKK Gene

Gene Tree for DGKK (if available)
Gene Tree for DGKK (if available)

Paralogs for DGKK Gene

Selected SIMAP similar genes for DGKK Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DGKK: view

No data available for Paralogs for DGKK Gene

Variants for DGKK Gene

Sequence variations from dbSNP and Humsavar for DGKK Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1129435 -- 50,365,645(-) TGTAA(C/T)CCATT utr-variant-3-prime
rs1316519 -- 50,414,916(+) CCATA(C/G)AACTA intron-variant
rs1320573 -- 50,397,981(-) ACATT(A/G)TCTTC intron-variant
rs1343771 -- 50,437,718(+) AGGAG(A/T)AGGAA intron-variant
rs1890600 -- 50,442,227(-) GAAAA(G/T)AGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DGKK Gene

Variant ID Type Subtype PubMed ID
nsv508771 CNV Insertion 20534489
nsv523598 CNV Gain 19592680

Relevant External Links for DGKK Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGKK Gene

Disorders for DGKK Gene

Relevant External Links for DGKK

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for DGKK Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DGKK Gene

Publications for DGKK Gene

  1. Identification and characterization of a novel human type II diacylglycerol kinase, DGK kappa. (PMID: 16210324) Imai S. … Sakane F. (J. Biol. Chem. 2005) 2 3 4
  2. Common variants in DGKK are strongly associated with risk of hypospadias. (PMID: 21113153) van der Zanden L.F. … Knoers N.V. (Nat. Genet. 2011) 3 48
  3. Aetiology of hypospadias: a systematic review of genes and environment. (PMID: 22371315) van der Zanden L.F. … Roeleveld N. (Hum. Reprod. Update 2012) 3
  4. Diacylglycerol kinase K variants impact hypospadias in a California study population. (PMID: 23177175) Carmichael S.L. … Lammer E.J. (J. Urol. 2013) 3
  5. Extracellular HIV-1 viral protein R affects astrocytic glyceraldehyde 3-phosphate dehydrogenase activity and neuronal survival. (PMID: 23728617) Ferrucci A. … Wigdahl B. (J. Neurovirol. 2013) 3

Products for DGKK Gene

  • Addgene plasmids for DGKK

Sources for DGKK Gene

Back to Top