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DGKI Gene

protein-coding   GIFtS: 59
GCID: GC07M137073

Diacylglycerol Kinase, Iota

  Search for DGKI
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Diacylglycerol Kinase, Iota1 2     DGK-IOTA2
Diglyceride Kinase Iota2 3     Diacylglycerol Kinase Iota2
DAG Kinase Iota2 3     DGK-iota3
EC 2.7.1.1073 8     

External Ids:    HGNC: 28551   Entrez Gene: 91622   Ensembl: ENSG000001576807   OMIM: 6040725   UniProtKB: O759123   

Export aliases for DGKI gene to outside databases

Previous GC identifers: GC07M135416 GC07M136475 GC07M136489 GC07M136530 GC07M136724 GC07M131379


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DGKI Gene:
This gene is a member of the type IV diacylglycerol kinase subfamily. Diacylglycerol kinases regulate the
intracellular concentration of diacylglycerol through its phosphorylation, producing phosphatidic acid. The
specific role of the enzyme encoded by this gene is undetermined, however, it may play a crucial role in the
production of phosphatidic acid in the retina or in recessive forms of retinal degeneration. (provided by RefSeq,
Jul 2008)

GeneCards Summary for DGKI Gene:
DGKI (diacylglycerol kinase, iota) is a protein-coding gene. GO annotations related to this gene include NAD+ kinase activity and GTPase inhibitor activity. An important paralog of this gene is DGKH.

summary for DGKI Gene:
Diacylglycerol kinases (DGKs) are a group of ten enzymes (DGKalpha, DGKbeta, DGKgamma, DGKdelta, DGKepsilon,
DGKzeta, DGKeta, DGKtheta, DGKiota and DGKkappa) that metabolize 1,2,diacylglycerol (DAG) to produce
phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain, two cysteine-rich
Zn2+-finger motifs that bind DAG and an ATP-binding site, whilst the regulatory domain varies. DGKs are
widely distributed throughout mammalian tissues and different isozymes have different subcellular
localizations; some are cytosolic (for example DGKalpha), some are membrane-bound (for example DGKgamma is
associated with the Golgi membrane) and some are nuclear (for example DGKzeta. DGKs have diverse biological
roles as they participate in signal transduction by modulating levels of DAG in a variety of cellular
responses to extracellular stimuli.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DGKI gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   E2F-1   E2F   COMP1   FOXO4   Hlf   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DGKI promoter sequence
   Search Chromatin IP Primers for DGKI

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DGKI


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32.3-q33   Ensembl cytogenetic band:  7q33   HGNC cytogenetic band: 7q32.3-q33

DGKI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DGKI gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M137073:  view genomic region     (about GC identifiers)

Start:
137,065,783 bp from pter      End:
137,531,838 bp from pter
Size:
466,056 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 136,418,404-136,876,991     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DGKI_HUMAN, O75912 (See protein sequence)
Recommended Name: Diacylglycerol kinase iota  
Size: 1065 amino acids; 116997 Da
Secondary accessions: A4D1Q9 Q9NZ49

Explore the universe of human proteins at neXtProt for DGKI: NX_O75912

Explore proteomics data for DGKI at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DGKI (O75912) (see all 14)
     PMQVDGE  VNPKSGG  ETNVSGD  DLTPKIQ 


    See DGKI Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004708.1  
    ENSEMBL proteins: 
     ENSP00000392161   ENSP00000288490   ENSP00000399131   ENSP00000396078  
    Reactome Protein details: O75912

    DGKI Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for DGKI
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    Novus Biologicals DGKI Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for DGKI 

    DGKI Antibody Products:

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    DGKI Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR001206 Diacylglycerol_kinase_cat_dom
     IPR000756 Diacylglycerol_kin_accessory
     IPR002110 Ankyrin_rpt
     IPR002219 Prot_Kinase_C-like_PE/DAG-bd
     IPR016064 ATP-NAD_kinase_PpnK-typ

    Graphical View of Domain Structure for InterPro Entry O75912

    ProtoNet protein and cluster: O75912

    2 Blocks protein domains:
    IPB000756 Diacylglycerol kinase accessory domain (presumed)
    IPB002110 Ankyrin repeat signature


    UniProtKB/Swiss-Prot: DGKI_HUMAN, O75912
    Similarity: Belongs to the eukaryotic diacylglycerol kinase family
    Similarity: Contains 2 ANK repeats
    Similarity: Contains 1 DAGKc domain
    Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers


    Find genes that share domains with DGKI           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DGKI_HUMAN, O75912
    Catalytic activity: ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate

         Genatlas biochemistry entry for DGKI:
    diacylglycerol kinase iota,expressed in the cytoplasm and nucleus of brain and retina

         Enzyme Number (IUBMB): EC 2.7.1.1071 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003951NAD+ kinase activity IEA--
    GO:0004143diacylglycerol kinase activity IEA--
    GO:0005095GTPase inhibitor activity IEA--
    GO:0005515protein binding IPI17986458
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with DGKI           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for DGKI:
     Decreased TP53 protein express  Increased cell death HMECs cel  Increased viability with 4OH t  Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Dgki):
     tumorigenesis 

    Find genes that share phenotypes with DGKI           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dgkitm1Mtop for DGKI

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DGKI
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DGKI

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DGKI
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DGKI

    miRNA
    Products:
        
    miRTarBase miRNAs that target DGKI:
    hsa-mir-26b-5p (MIRT028926)

    Block miRNA regulation of human, mouse, rat DGKI using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DGKI (see all 24):
    hsa-miR-1287 hsa-miR-34b* hsa-miR-4311 hsa-miR-125a-3p hsa-miR-3942-5p hsa-miR-938 hsa-miR-449a hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidDGKI 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DGKI
    Predesigned siRNA for gene silencing in human, mouse, rat DGKI

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: DGKI (NM_004717)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DGKI
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DGKI
    Addgene plasmids for DGKI 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGKI


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DGKI_HUMAN, O75912: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane4
    cytosol3
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm TAS9830018
    GO:0005886plasma membrane TAS--
    GO:0032045guanyl-nucleotide exchange factor complex IEA--

    Find genes that share ontologies with DGKI           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DGKI About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    3Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    4Glycerophospholipid biosynthesis
    Glycerophospholipid metabolism0.62
    5Inositol phosphate metabolism (KEGG)
    Phosphatidylinositol signaling system0.61


    Find genes that share SuperPaths with DGKI           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for DGKI
        Effects of PIP2 hydrolysis


    4 Kegg Pathways  (Kegg details for DGKI):
        Glycerolipid metabolism
    Glycerophospholipid metabolism
    Metabolic pathways
    Phosphatidylinositol signaling system

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DGKI
    Interactions:

        Search GeneGlobe Interaction Network for DGKI

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DGKI (O759121, 3 ENSP000002884904) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VHLP40337-31, ENSP000002564744EBI-1765520,EBI-301270 I2D: score=1 STRING: ENSP00000256474
    GNAQP501483, ENSP000002865484I2D: score=1 STRING: ENSP00000286548
    PLCB4Q151473, ENSP000003341054I2D: score=1 STRING: ENSP00000334105
    PTCH1Q136353I2D: score=3 
    AGPAT2ENSP000003607614STRING: ENSP00000360761
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway IEA--
    GO:0007596blood coagulation TAS--
    GO:0030168platelet activation TAS--
    GO:0032317regulation of Rap GTPase activity IEA--
    GO:0035556intracellular signal transduction IEA--

    Find genes that share ontologies with DGKI           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for DGKI available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DioctanoylglycolDiacylglycerol kinase inhibitor[627-86-1]

    Selected HMDB Compounds for DGKI (see all 862)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DGKI gene: 
    NM_004717.2  

    Unigene Cluster for DGKI:

    Diacylglycerol kinase, iota
    Hs.242947  [show with all ESTs]
    Unigene Representative Sequence: AB209167
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000453654(uc003vtt.3 uc003vtu.3) ENST00000494390 ENST00000288490
    ENST00000446122 ENST00000424189 ENST00000477835 ENST00000486153 ENST00000497321
    ENST00000460662 ENST00000470895 ENST00000483619 ENST00000475388
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DGKI (see all 24):
    hsa-miR-1287 hsa-miR-34b* hsa-miR-4311 hsa-miR-125a-3p hsa-miR-3942-5p hsa-miR-938 hsa-miR-449a hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidDGKI 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: DGKI (NM_004717)
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    Addgene plasmids for DGKI 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DGKI
      QuantiTect SYBR Green Assays in human, mouse, rat DGKI
      QuantiFast Probe-based Assays in human, mouse, rat DGKI

    Additional mRNA sequence: 

    AB209167.1 AK091081.1 

    5 DOTS entries:

    DT.102840373  DT.430796  DT.100742339  DT.40233584  DT.92016611 

    21 AceView cDNA sequences:

    CA388725 BF589937 BQ014815 AA707274 NM_004717 AL049128 AA394218 AA247129 
    AK091081 H00453 AA904515 BV181859 AA058772 AA398117 AA001220 AF061936 
    BX095830 AA081522 R54195 R54194 H37913 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DGKI expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DGKI Expression
    About this image

    DGKI Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DGKI Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.242947
        Custom PCR Arrays for DGKI
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    QuantiFast Probe-based Assays in human, mouse, rat DGKI
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGKI

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DGKI gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dgki1 , 5 diacylglycerol kinase, iota1, 5 90.38(n)1
    95.19(a)1
      6 (15.60 cM)5
    3201271  NM_001081206.11  NP_001074675.11 
     368460225 
    chicken
    (Gallus gallus)
    Aves DGKI1 diacylglycerol kinase, iota 80.41(n)
    87.18(a)
      418124  XM_416357.4  XP_416357.4 
    lizard
    (Anolis carolinensis)
    Reptilia DGKI6
    diacylglycerol kinase, iota
    87(a)
    1 ↔ 1
    GL343419.1(1232-149226)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.163372 Xenopus laevis transcribed sequence with moderate similarity more 83.31(n)    BJ043357.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dgki1 diacylglycerol kinase, iota 69.41(n)
    73.7(a)
      100331649  XM_002666976.3  XP_002667022.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta rdgA3 deactivation of rhodopsin mediated
    signaling diacylglycerol more
    41(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea K06A1.63 DIACYLGLYCEROL KINASE 38(a)   II(6456806-6467586)   --


    ENSEMBL Gene Tree for DGKI (if available)
    TreeFam Gene Tree for DGKI (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DGKI gene
    DGKH2  DGKQ2  DGKB2  DGKE2  DGKZ2  DGKA2  DGKG2  DGKD2  
    3 SIMAP similar genes for DGKI using alignment to 4 protein entries:     DGKI_HUMAN (see all proteins):
    DGKZ    DGKA    DGKB

    Find genes that share paralogs with DGKI           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DGKI (see all 9105)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58878491,2
    C--131676858(+) ATCTA-/AGAGTGG 1 -- int11Minor allele frequency- AG:0.00NA 2
    rs679827931,2
    C--136497080(+) AAACT-/ATGGAGT 1 -- int11Minor allele frequency- AT:0.00NA 2
    rs1173179931,2
    C,F--137073962(+) AGCTTC/ATGGAA 1 -- ds50011Minor allele frequency- A:0.11EA 120
    rs768777031,2
    --137074035(+) TGGAAA/GTAGAT 1 -- ds50010--------
    rs1424736461,2
    --137074043(+) GATTAC/GTCACA 1 -- ds50010--------
    rs1181235721,2
    F--137074132(+) GAAAGG/CCTGTT 1 -- ds50011Minor allele frequency- C:0.03NA 120
    rs1171007581,2
    C,F--137074133(+) AAAGGC/TTGTTC 1 -- ds50011Minor allele frequency- T:0.01NA 120
    rs1870055311,2
    --137074300(+) CTATGC/TCCAAG 1 -- ds50010--------
    rs1914362801,2
    --137074332(+) GGAGAC/TGTCAG 1 -- ds50010--------
    rs1842755861,2
    --137074484(+) TACCAC/TTCGAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DGKI (137065783 - 137315783 bp, first 250kb of DGKI)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DGKI (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667508CNV Deletion23128226
    esv2735210CNV Deletion23290073
    esv2672944CNV Deletion23128226
    esv2677586CNV Deletion23128226
    esv2031397CNV Deletion18987734
    esv2224181CNV Deletion18987734
    esv2428797CNV Deletion19546169
    esv2735208CNV Deletion23290073
    esv2735209CNV Deletion23290073
    esv2735207CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 604072    OMIM disorders: --


    Find genes that share disorders with DGKI           About GenesLikeMe

    Genetic Association Database (GAD): DGKI
    Human Genome Epidemiology (HuGE) Navigator: DGKI (3 documents)

    Export disorders for DGKI gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for DGKI gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with DGKI)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The cloning and characterization of a novel human diacylglycerol kinase, DGK-iota. (PubMed id 9830018)1, 2, 3, 9 Ding L.... Prescott S.M. (J. Biol. Chem. 1998)
    2. Genome-wide association study implicates PARD3B-based AIDS restriction. (PubMed id 21502085)1, 4 Troyer J.L....O'Brien S.J. (J. Infect. Dis. 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk. (PubMed id 19065143)1, 4 Moskvina V....O'Donovan M.C. (Mol. Psychiatry 2009)
    5. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    6. Evaluation of human diacylglycerol kinase iota, DGKI, a homolog of Drosophila rdgA, in inherited retinopathy mapping to 7q. (PubMed id 10706894)1, 2 Bowne S.J.... Daiger S.P. (Mol. Vis. 2000)
    7. SNP variations in the 7q33 region containing DGKI are associated with dyslexia in the Finnish and German populations. (PubMed id 21203819)1 Matsson H....Peyrard-Janvid M. (Behav. Genet. 2011)
    8. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)
    9. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PubMed id 17903295)4 Lunetta K.L....Murabito J.M. (BMC Med. Genet. 2007)
    10. A yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor protein. (PubMed id 17986458)1 Bex C....Buchberger A. (Nucleic Acids Res. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 9162 HGNC: 2855 AceView: DGKI Ensembl:ENSG00000157680 euGenes: HUgn9162
    ECgene: DGKI Kegg: 9162 H-InvDB: DGKI

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DGKI Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DGKI gene:
    Search GeneIP for patents involving DGKI

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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