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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DGKI Gene

protein-coding   GIFtS: 57
GCID: GC07M137073

diacylglycerol kinase, iota
 Explore 5 diseases affiliated with
DGKI via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DGKI    

Aliases
for DGKI gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Diacylglycerol Kinase, Iota1 2     EC 2.7.1.1073 8
DGK-IOTA1 2     Diacylglycerol Kinase Iota2
Diglyceride Kinase Iota2 3     DGK-Iota1
DAG Kinase Iota2 3     

External Ids:    HGNC: 28551   Entrez Gene: 91622   Ensembl: ENSG000001576807   OMIM: 6040725   UniProtKB: O759123   

Export aliases for DGKI gene to outside databases

Previous GC identifers: GC07M135416 GC07M136475 GC07M136489 GC07M136530 GC07M136724 GC07M131379


Summaries
for DGKI gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DGKI:
This gene is a member of the type IV diacylglycerol kinase subfamily. Diacylglycerol kinases regulate the intracellular
concentration of diacylglycerol through its phosphorylation, producing phosphatidic acid. The specific role of the
enzyme encoded by this gene is undetermined, however, it may play a crucial role in the production of phosphatidic
acid in the retina or in recessive forms of retinal degeneration. (provided by RefSeq, Jul 2008)

summary for DGKI:
Diacylglycerol kinases (DGKs) are a group of ten enzymes (DGKalpha, DGKbeta, DGKgamma, DGKdelta, DGKepsilon,
DGKzeta, DGKeta, DGKtheta, DGKiota and DGKkappa) that metabolize 1,2,diacylglycerol (DAG) to produce
phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain, two cysteine-rich
Zn2+-finger motifs that bind DAG and an ATP-binding site, whilst the regulatory domain varies. DGKs are
widely distributed throughout mammalian tissues and different isozymes have different subcellular
localizations; some are cytosolic (for example DGKalpha), some are membrane-bound (for example DGKgamma is
associated with the Golgi membrane) and some are nuclear (for example DGKzeta. DGKs have diverse biological
roles as they participate in signal transduction by modulating levels of DAG in a variety of cellular
responses to extracellular stimuli.




Genomic Views
for DGKI gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DGKI gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   E2F-1   E2F   COMP1   FOXO4   Hlf   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DGKI promoter sequence
   Search SABiosciences Chromatin IP Primers for DGKI

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DGKI


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32.3-q33   Ensembl cytogenetic band:  7q33   HGNC cytogenetic band: 7q32.3-q33

DGKI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DGKI gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M137073:  view genomic region     (about GC identifiers)

Start:
 137,073,563 bp from pter      End:
 137,531,838 bp from pter
Size:
 458,276 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 136,418,404-136,876,991     

Proteins
for DGKI gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DGKI_HUMAN, O75912 (See protein sequence)
Recommended Name: Diacylglycerol kinase iota  
Size: 1065 amino acids; 116997 Da
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: A4D1Q9 Q9NZ49

Explore the universe of human proteins at neXtProt for DGKI: NX_O75912

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75912

    • 4/14 DME Specific Peptides for DGKI (O75912) (see all 14)
     PMQVDGE  VNPKSGG  ETNVSGD  DLTPKIQ 

    DGKI Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004708.1  
    ENSEMBL proteins: 
     ENSP00000392161   ENSP00000396078   ENSP00000288490   ENSP00000399131  
    Reactome Protein details: O75912
    Human Recombinant Protein Products: 
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    Browse Proteins at Uscn

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm TAS9830018
    GO:0005886plasma membrane TAS--
    GO:0032045guanyl-nucleotide exchange factor complex IEA--


    DGKI for ontologies           About GeneDecksing



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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for DGKI gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DGKI for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR001206 Diacylglycerol_kinase_cat_dom
     IPR002219 Prot_Kinase_C-like_PE/DAG-bd
     IPR000756 Diacylglycerol_kin_accessory
     IPR020683 Ankyrin_rpt-contain_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry O75912

    ProtoNet protein and cluster: O75912

    2 Blocks protein families:
    IPB000756 Diacylglycerol kinase accessory domain (presumed)
    IPB002110 Ankyrin repeat signature


    UniProtKB/Swiss-Prot: DGKI_HUMAN, O75912
    Similarity: Belongs to the eukaryotic diacylglycerol kinase family
    Similarity: Contains 2 ANK repeats
    Similarity: Contains 1 DAGKc domain
    Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers


    Function
    for DGKI gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DGKI_HUMAN, O75912
    Catalytic activity: ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate

         Genatlas biochemistry entry for DGKI:
    diacylglycerol kinase iota,expressed in the cytoplasm and nucleus of brain and retina

    Enzyme Number (IUBMB): EC 2.7.1.1071 2

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DGKI
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate DGKI (see all 24):
    hsa-miR-1287 hsa-miR-34b* hsa-miR-4311 hsa-miR-125a-3p hsa-miR-3942-5p hsa-miR-938 hsa-miR-449a hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmid: DGKI 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DGKI (see all 7)
    OriGene shRNA RFP: DGKI
    OriGene siRNA: DGKI
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004143diacylglycerol kinase activity IEA--
    GO:0005095GTPase inhibitor activity IEA--
    GO:0005515protein binding IPI17986458
    GO:0005524ATP binding IEA--
    GO:0017016Ras GTPase binding IEA--


    DGKI for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for DGKI:
     Decreased TP53 protein express  Increased cell death HMECs cel  Increased viability with 4OH t  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Dgkitm1Mtop for DGKI
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Dgki):
     tumorigenesis 

    DGKI for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DGKI gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    2Platelet activation, signaling and aggregation
    		Platelet activation, signaling and aggregation1.00
    		Hemostasis0.43
    3G alpha (q) signalling events
    		G alpha (q) signalling events1.00
    		Gastrin-CREB signalling pathway via PKC and MAPK0.90
    4Effects of PIP2 hydrolysis
    		Effects of PIP2 hydrolysis1.00
    5Glycerolipid metabolism
    		Glycerolipid metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/8        Reactome Pathways for DGKI (see all 8)
        GPCR downstream signaling
    Hemostasis
    Effects of PIP2 hydrolysis
    Signal Transduction
    Gastrin-CREB signalling pathway via PKC and MAPK


    4         Kegg Pathways  (Kegg details for DGKI):
        Glycerolipid metabolism
    Glycerophospholipid metabolism
    Metabolic pathways
    Phosphatidylinositol signaling system


    DGKI for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DGKI

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/45 Interacting proteins for DGKI (O759121, 3 ENSP000002884904) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VHLP40337-31, ENSP000002564744EBI-1765520,EBI-301270 I2D: score=1 STRING: ENSP00000256474
    PLCB4Q151473, ENSP000003341054I2D: score=1 STRING: ENSP00000334105
    PTCH1Q136353I2D: score=3 
    GNAQP501483I2D: score=1 
    AGPAT2ENSP000003607614STRING: ENSP00000360761
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway IEA--
    GO:0007596blood coagulation TAS--
    GO:0030168platelet activation TAS--
    GO:0032317regulation of Rap GTPase activity IEA--
    GO:0035556intracellular signal transduction IEA--


    DGKI for ontologies           About GeneDecksing



    Drugs & Compounds
    for DGKI gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for DGKI:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for DGKI available from Tocris Bioscience    About this table
    CompoundAction CAS #
    R 59-022Diacylglycerol kinase inhibitor; increases PKC activity[93076-89-2]
    DioctanoylglycolDiacylglycerol kinase inhibitor[627-86-1]

    10/862 HMDB Compounds for DGKI (see all 862)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    Search CenterWatch for drugs/clinical trials and news about DGKI 

    Transcripts
    for DGKI gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DGKI gene: 
    NM_004717.2  

    Unigene Cluster for DGKI:

    Diacylglycerol kinase, iota
    Hs.242947  [show with all ESTs]
    Unigene Representative Sequence: AB209167
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000453654(uc003vtt.3 uc003vtu.3) ENST00000494390 ENST00000424189
    ENST00000288490 ENST00000446122 ENST00000477835 ENST00000486153 ENST00000497321
    ENST00000460662 ENST00000470895 ENST00000483619 ENST00000475388

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DGKI
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate DGKI (see all 24):
    hsa-miR-1287 hsa-miR-34b* hsa-miR-4311 hsa-miR-125a-3p hsa-miR-3942-5p hsa-miR-938 hsa-miR-449a hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmid: DGKI 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AB209167.1 AK091081.1 

    5 DOTS entries:

    DT.102840373  DT.430796  DT.100742339  DT.40233584  DT.92016611 

    21 AceView cDNA sequences:

    BQ014815 CA388725 NM_004717 AA707274 BF589937 AL049128 BV181859 AA058772 
    AK091081 AA247129 AA394218 H00453 AA904515 AA001220 AF061936 AA398117 
    AA081522 BX095830 R54195 R54194 H37913 

    GeneLoc Exon Structure


    Expression
    for DGKI gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DGKI expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See DGKI Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DGKI

    SOURCE GeneReport for Unigene cluster: Hs.242947
        SABiosciences Custom PCR Arrays for DGKI
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGKI

    Orthologs
    for DGKI gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DGKI gene from 8/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DGKI1 diacylglycerol kinase, iota 79.19(n)
    85.17(a)    		   418124  XM_416357.3  XP_416357.3 
    lizard
    (Anolis carolinensis)    		 Reptilia DGKI6
    		 --
    		 87(a)
    		 1 ↔ 1
    		 GL343419.1(1232-149226)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.163372 Xenopus laevis transcribed sequence with moderate similarity more 83.31(n)    BJ043357.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii dgki1 diacylglycerol kinase, iota 69.52(n)
    73.75(a)    		   100331649  XM_002666976.2  XP_002667022.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta rdgA3 deactivation of rhodopsin mediated signaling
    diacylglycerol more    		 41(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea K06A1.63 DIACYLGLYCEROL KINASE 38(a)   II(6456806-6467586)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons DGK66
    ATDGK56
    (see all 7)    		 diacylglycerol kinase 5
    (see all 7)    		 25(a)
    24(a)
    (see all 7)    		 possible ortholog
    possible ortholog
    (see all 7)    		 4(13971552-13974323)
    2(8989275-8993114)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 8)    		 diacylglycerol kinase, putative, expressed
    (see all 8)    		 24(a)
    24(a)
    (see all 8)    		 many ↔ many
    possible ortholog
    (see all 8)    		 12(6728516-6733263)
    1(33184286-33191935)


    ENSEMBL Gene Tree for DGKI (if available)
    TreeFam Gene Tree for DGKI (if available) 

    Paralogs
    for DGKI gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DGKI gene
    DGKA2  DGKH2  DGKQ2  DGKG2  DGKB2  DGKD2  DGKE2  DGKZ2  
    2 SIMAP similar genes for DGKI using alignment to 4 protein entries:     DGKI_HUMAN (see all proteins):
    DGKZ    DGKA

    DGKI for paralogs           About GeneDecksing



    Genomic Variants
    for DGKI gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7801 NCBI SNPs in DGKI are shown (see all 7801)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs102819501,2
    		C,F,H,--136697809(+) ATTTCT/CAGTTA 1 -- ds500116Minor allele frequency- C:0.06NA NS EA WA EU 2201
    rs769483721,2
    		F,--136698124(+) GTAGGT/CACGAC 1 -- nc-transcript-variant1Minor allele frequency- C:0.13WA 118
    rs2709051,2
    		C,F,H,--136698204(-) AGAAAG/CACTTC 1 -- nc-transcript-variant15Minor allele frequency- C:0.03MN NS EA NA WA 1448
    rs1122341721,2
    		--136698966(+) GAGGAG/AACAGA 1 -- nc-transcript-variant1Minor allele frequency- A:0.00CSA 1
    rs2000913481,2
    		C--136699098(+) CCTGTA/GATTTG 1 -- nc-transcript-variant0--------
    rs1162871031,2
    		C,F,--136699121(+) TATATA/GTGCAT 1 -- nc-transcript-variant1Minor allele frequency- G:0.08WA 118
    rs756125481,2
    		C,--136699287(+) TCACAC/TGCTTC 1 -- nc-transcript-variant2Minor allele frequency- T:0.14CSA WA 120
    rs755023281,2
    		F,--136699843(+) TTTGGC/TTTAAT 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs171693711,2
    		C,--136700523(+) ATAACG/AATCCC 1 -- us2k13Minor allele frequency- A:0.01NA 142
    rs77932521,2
    		C,F,H,--136701056(+) TGCTGG/ATGCTC 1 -- us2k15Minor allele frequency- A:0.02NS EA WA 538

    HapMap Linkage Disequilibrium report for DGKI (137073563 - 137323563 bp, first 250kb of DGKI)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 11 variations for DGKI
         3 CNVs: 52101 100138 7605
         8 Indels: 34317 41030 12968 12969 47247 47246 62730 12967

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for DGKI gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DGKI for disorders           About GeneDecksing

    OMIM gene information: 604072    OMIM disorders: --

    5 diseases for DGKI:    About MalaCards
    retinal degeneration    retinitis    dyslexia    malaria
    alcoholism

    Human Genome Epidemiology (HuGE) Navigator: DGKI (3 documents)

    Export disorders for DGKI gene to outside databases

    Publications
    for DGKI gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DGKI gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with DGKI)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The cloning and characterization of a novel human diacylglycerol kinase, DGK-iota. (PubMed id 9830018)1, 2, 3, 9 Ding L.... Prescott S.M. (1998)
    2. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    3. Evaluation of human diacylglycerol kinase iota, DGKI, a homolog of Drosophila rdgA, in inherited retinopathy mapping to 7q. (PubMed id 10706894)1, 2 Bowne S.J.... Daiger S.P. (2000)
    4. Genome-wide association study implicates PARD3B-based AIDS restriction. (PubMed id 21502085)1 Troyer J.L....O'Brien S.J. (2011)
    5. SNP variations in the 7q33 region containing DGKI are associated with dyslexia in the Finnish and German populations. (PubMed id 21203819)1 Matsson H....Peyrard-Janvid M. (2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk. (PubMed id 19065143)1 Moskvina V....O'Donovan M.C. (2009)
    8. A yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor protein. (PubMed id 17986458)1 Bex C....Buchberger A. (2007)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    10. Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures. (PubMed id 12486725)6 Kurz M....Kramer W. (2003)

    External Searches for DGKI gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing DGKI gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9162 HGNC: 2855 AceView: DGKI Ensembl:ENSG00000157680 euGenes: HUgn9162
    ECgene: DGKI Kegg: 9162 H-InvDB: DGKI

    Other Databases showing DGKI gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DGKI gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DGKI Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DGKI gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DGKI gene:
    Search GeneIP for patents involving DGKI

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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