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Aliases for DGKI Gene

Aliases for DGKI Gene

  • Diacylglycerol Kinase Iota 2 3
  • Diacylglycerol Kinase, Iota 3 5
  • Diglyceride Kinase Iota 3 4
  • DAG Kinase Iota 3 4
  • EC 2.7.1.107 4 63
  • DGK-IOTA 3 4

External Ids for DGKI Gene

Previous GeneCards Identifiers for DGKI Gene

  • GC07M135416
  • GC07M136475
  • GC07M136489
  • GC07M136530
  • GC07M136724
  • GC07M137073
  • GC07M131379

Summaries for DGKI Gene

Entrez Gene Summary for DGKI Gene

  • This gene is a member of the type IV diacylglycerol kinase subfamily. Diacylglycerol kinases regulate the intracellular concentration of diacylglycerol through its phosphorylation, producing phosphatidic acid. The specific role of the enzyme encoded by this gene is undetermined, however, it may play a crucial role in the production of phosphatidic acid in the retina or in recessive forms of retinal degeneration. [provided by RefSeq, Jul 2008]

GeneCards Summary for DGKI Gene

DGKI (Diacylglycerol Kinase Iota) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include NAD+ kinase activity and diacylglycerol kinase activity. An important paralog of this gene is DGKH.

Tocris Summary for DGKI Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.

No data available for UniProtKB/Swiss-Prot , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGKI Gene

Genomics for DGKI Gene

Regulatory Elements for DGKI Gene

Promoters for DGKI Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DGKI on UCSC Golden Path with GeneCards custom track

Genomic Location for DGKI Gene

Chromosome:
7
Start:
137,381,037 bp from pter
End:
137,847,092 bp from pter
Size:
466,056 bases
Orientation:
Minus strand

Genomic View for DGKI Gene

Genes around DGKI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGKI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGKI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKI Gene

Proteins for DGKI Gene

  • Protein details for DGKI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75912-DGKI_HUMAN
    Recommended name:
    Diacylglycerol kinase iota
    Protein Accession:
    O75912
    Secondary Accessions:
    • A4D1Q9
    • Q9NZ49

    Protein attributes for DGKI Gene

    Size:
    1065 amino acids
    Molecular mass:
    116997 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DGKI Gene

Proteomics data for DGKI Gene at MOPED

Post-translational modifications for DGKI Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for DGKI Gene

Suggested Antigen Peptide Sequences for DGKI Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75912

UniProtKB/Swiss-Prot:

DGKI_HUMAN :
  • Contains 1 DAGKc domain.
  • Belongs to the eukaryotic diacylglycerol kinase family.
  • Contains 2 ANK repeats.
Domain:
  • Contains 1 DAGKc domain.
Family:
  • Belongs to the eukaryotic diacylglycerol kinase family.
Similarity:
  • Contains 2 ANK repeats.
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
genes like me logo Genes that share domains with DGKI: view

Function for DGKI Gene

Molecular function for DGKI Gene

GENATLAS Biochemistry:
diacylglycerol kinase iota,expressed in the cytoplasm and nucleus of brain and retina
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Enzyme Numbers (IUBMB) for DGKI Gene

Gene Ontology (GO) - Molecular Function for DGKI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 17986458
genes like me logo Genes that share ontologies with DGKI: view
genes like me logo Genes that share phenotypes with DGKI: view

Animal Models for DGKI Gene

MGI Knock Outs for DGKI:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DGKI Gene

Localization for DGKI Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGKI Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DGKI Gene COMPARTMENTS Subcellular localization image for DGKI gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for DGKI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus TAS 9830018
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,TAS 9830018
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with DGKI: view

Pathways & Interactions for DGKI Gene

genes like me logo Genes that share pathways with DGKI: view

Gene Ontology (GO) - Biological Process for DGKI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0007596 blood coagulation TAS --
GO:0034260 negative regulation of GTPase activity IEA --
GO:0046579 positive regulation of Ras protein signal transduction IEA --
genes like me logo Genes that share ontologies with DGKI: view

No data available for SIGNOR curated interactions for DGKI Gene

Drugs & Compounds for DGKI Gene

(1) Drugs for DGKI Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(24) Additional Compounds for DGKI Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(2) Tocris Compounds for DGKI Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor 627-86-1
R 59-022 Diacylglycerol kinase inhibitor; increases PKC activity 93076-89-2
genes like me logo Genes that share compounds with DGKI: view

Transcripts for DGKI Gene

Unigene Clusters for DGKI Gene

Diacylglycerol kinase, iota:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DGKI Gene

No ASD Table

Relevant External Links for DGKI Gene

GeneLoc Exon Structure for
DGKI
ECgene alternative splicing isoforms for
DGKI

Expression for DGKI Gene

mRNA expression in normal human tissues for DGKI Gene

mRNA differential expression in normal tissues according to GTEx for DGKI Gene

This gene is overexpressed in Thyroid (x5.8).

Protein differential expression in normal tissues from HIPED for DGKI Gene

This gene is overexpressed in Fetal Brain (29.0), Neutrophil (12.3), Pancreatic juice (11.6), and Frontal cortex (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DGKI Gene



SOURCE GeneReport for Unigene cluster for DGKI Gene Hs.242947

genes like me logo Genes that share expression patterns with DGKI: view

Protein tissue co-expression partners for DGKI Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DGKI Gene

Orthologs for DGKI Gene

This gene was present in the common ancestor of animals.

Orthologs for DGKI Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DGKI 35
  • 92.91 (n)
  • 96.65 (a)
DGKI 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DGKI 35
  • 94.49 (n)
  • 97.92 (a)
DGKI 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dgki 35
  • 90.38 (n)
  • 95.19 (a)
Dgki 16
Dgki 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DGKI 35
  • 99.37 (n)
  • 99.34 (a)
DGKI 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dgki 35
  • 90.45 (n)
  • 95.67 (a)
oppossum
(Monodelphis domestica)
Mammalia DGKI 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DGKI 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves DGKI 35
  • 80.41 (n)
  • 87.18 (a)
DGKI 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DGKI 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dgki 35
  • 70.19 (n)
  • 75.65 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16337 35
zebrafish
(Danio rerio)
Actinopterygii dgki 35
  • 69.41 (n)
  • 73.7 (a)
DGKI 36
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta rdgA 37
  • 41 (a)
rdgA 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K06A1.6 37
  • 38 (a)
dgk-5 36
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToMany
Species with no ortholog for DGKI:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DGKI Gene

ENSEMBL:
Gene Tree for DGKI (if available)
TreeFam:
Gene Tree for DGKI (if available)

Paralogs for DGKI Gene

Paralogs for DGKI Gene

(3) SIMAP similar genes for DGKI Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DGKI: view

Variants for DGKI Gene

Sequence variations from dbSNP and Humsavar for DGKI Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs61757580 - 137,689,947(+) AGGAA(A/G)GCTGA reference, missense
rs321188 -- 137,395,385(+) TATAA(A/G)GCCCC intron-variant
rs270890 -- 137,696,493(-) GCATT(C/T)AGCTG intron-variant
rs270891 -- 137,648,213(-) TCTGA(A/C)CATCA intron-variant
rs270892 -- 137,683,690(-) ATGGA(G/T)ACTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DGKI Gene

Variant ID Type Subtype PubMed ID
nsv889235 CNV Loss 21882294
esv33947 CNV Gain 17666407
nsv889242 CNV Loss 21882294
nsv518230 CNV Loss 19592680
esv2735207 CNV Deletion 23290073
esv2224181 CNV Deletion 18987734
esv2735208 CNV Deletion 23290073
nsv520950 CNV Loss 19592680
esv1745681 CNV Insertion 17803354
esv2677586 CNV Deletion 23128226
esv2672944 CNV Deletion 23128226
nsv366883 CNV Loss 16902084
esv2735209 CNV Deletion 23290073
esv270457 CNV Insertion 20981092
nsv464731 CNV Loss 19166990
nsv824315 CNV Loss 20364138
nsv511992 CNV Loss 21212237
esv2428797 CNV Deletion 19546169
esv2735210 CNV Deletion 23290073
esv2031397 CNV Deletion 18987734
esv9134 CNV Loss 19470904
esv2661659 CNV Deletion 23128226
dgv238n6 CNV Loss 16902084
nsv831150 CNV Gain+Loss 17160897
esv2667508 CNV Deletion 23128226

Variation tolerance for DGKI Gene

Residual Variation Intolerance Score: 4.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.91; 59.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DGKI Gene

HapMap Linkage Disequilibrium report
DGKI

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGKI Gene

Disorders for DGKI Gene

Relevant External Links for DGKI

Genetic Association Database (GAD)
DGKI
Human Genome Epidemiology (HuGE) Navigator
DGKI
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DGKI

No disorders were found for DGKI Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DGKI Gene

Publications for DGKI Gene

  1. The cloning and characterization of a novel human diacylglycerol kinase, DGK-iota. (PMID: 9830018) Ding L. … Prescott S.M. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. Genetic susceptibility to accelerated cognitive decline in the US Health and Retirement Study. (PMID: 24468470) Zhang C. … Pierce B.L. (Neurobiol. Aging 2014) 3
  4. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  5. DGKI methylation status modulates the prognostic value of MGMT in glioblastoma patients treated with combined radio-chemotherapy with temozolomide. (PMID: 25233099) Etcheverry A. … Mosser J. (PLoS ONE 2014) 3

Products for DGKI Gene

Sources for DGKI Gene

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