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Aliases for DGKI Gene

Aliases for DGKI Gene

  • Diacylglycerol Kinase, Iota 2 3
  • Diglyceride Kinase Iota 3 4
  • DAG Kinase Iota 3 4
  • EC 4 63
  • DGK-IOTA 3 4
  • Diacylglycerol Kinase Iota 3

External Ids for DGKI Gene

Previous GeneCards Identifiers for DGKI Gene

  • GC07M135416
  • GC07M136475
  • GC07M136489
  • GC07M136530
  • GC07M136724
  • GC07M137073
  • GC07M131379

Summaries for DGKI Gene

Entrez Gene Summary for DGKI Gene

  • This gene is a member of the type IV diacylglycerol kinase subfamily. Diacylglycerol kinases regulate the intracellular concentration of diacylglycerol through its phosphorylation, producing phosphatidic acid. The specific role of the enzyme encoded by this gene is undetermined, however, it may play a crucial role in the production of phosphatidic acid in the retina or in recessive forms of retinal degeneration. [provided by RefSeq, Jul 2008]

GeneCards Summary for DGKI Gene

DGKI (Diacylglycerol Kinase, Iota) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include NAD+ kinase activity and GTPase inhibitor activity. An important paralog of this gene is DGKH.

Tocris Summary for DGKI Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes (DGKalpha, DGKbeta, DGKgamma, DGKdelta, DGKepsilon, DGKzeta, DGKeta, DGKtheta, DGKiota and DGKkappa) that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain, two cysteine-rich Zn2+-finger motifs that bind DAG and an ATP-binding site, whilst the regulatory domain varies. DGKs are widely distributed throughout mammalian tissues and different isozymes have different subcellular localizations; some are cytosolic (for example DGKalpha), some are membrane-bound (for example DGKgamma is associated with the Golgi membrane) and some are nuclear (for example DGKzeta. DGKs have diverse biological roles as they participate in signal transduction by modulating levels of DAG in a variety of cellular responses to extracellular stimuli.

No data available for UniProtKB/Swiss-Prot , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGKI Gene

Genomics for DGKI Gene

Regulatory Elements for DGKI Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DGKI Gene

137,381,037 bp from pter
137,847,092 bp from pter
466,056 bases
Minus strand

Genomic View for DGKI Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DGKI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKI Gene

Proteins for DGKI Gene

  • Protein details for DGKI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Diacylglycerol kinase iota
    Protein Accession:
    Secondary Accessions:
    • A4D1Q9
    • Q9NZ49

    Protein attributes for DGKI Gene

    1065 amino acids
    Molecular mass:
    116997 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DGKI Gene

Proteomics data for DGKI Gene at MOPED

Post-translational modifications for DGKI Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DGKI Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for DGKI Gene

Gene Families for DGKI Gene

Suggested Antigen Peptide Sequences for DGKI Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DAGKc domain.
  • Belongs to the eukaryotic diacylglycerol kinase family.
  • Contains 2 ANK repeats.
  • Contains 1 DAGKc domain.
  • Belongs to the eukaryotic diacylglycerol kinase family.
  • Contains 2 ANK repeats.
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
genes like me logo Genes that share domains with DGKI: view

Function for DGKI Gene

Molecular function for DGKI Gene

GENATLAS Biochemistry:
diacylglycerol kinase iota,expressed in the cytoplasm and nucleus of brain and retina
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate

Enzyme Numbers (IUBMB) for DGKI Gene

Gene Ontology (GO) - Molecular Function for DGKI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003951 NAD+ kinase activity IEA --
GO:0004143 diacylglycerol kinase activity IEA --
GO:0005095 GTPase inhibitor activity IEA --
GO:0005515 protein binding IPI 17986458
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DGKI: view
genes like me logo Genes that share phenotypes with DGKI: view

Animal Models for DGKI Gene

MGI Knock Outs for DGKI:

Animal Model Products

miRNA for DGKI Gene

miRTarBase miRNAs that target DGKI

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DGKI

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for DGKI Gene

Localization for DGKI Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGKI Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for DGKI Gene COMPARTMENTS Subcellular localization image for DGKI gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for DGKI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9830018
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm TAS 9830018
GO:0005886 plasma membrane TAS --
GO:0032045 guanyl-nucleotide exchange factor complex IEA --
genes like me logo Genes that share ontologies with DGKI: view

Pathways for DGKI Gene

genes like me logo Genes that share pathways with DGKI: view

Gene Ontology (GO) - Biological Process for DGKI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0007596 blood coagulation TAS --
GO:0016310 phosphorylation IEA --
GO:0030168 platelet activation TAS --
GO:0034260 negative regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with DGKI: view

Drugs for DGKI Gene

(1) Tocris Compounds for DGKI Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor [627-86-1]

(1297) HMDB Compounds for DGKI Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(Tetrahydrogen triphosphate) Adenosine
  • Adenosindiphosphorsaeure
  • 1-Myristoyl-3-myristoyl-sn-glycerol
  • 1-Myristoyl-3-myristoleoyl-sn-glycerol
  • 1-Myristoyl-3-pentadecanoyl-sn-glycerol
genes like me logo Genes that share compounds with DGKI: view

Transcripts for DGKI Gene

Unigene Clusters for DGKI Gene

Diacylglycerol kinase, iota:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DGKI

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DGKI Gene

No ASD Table

Relevant External Links for DGKI Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DGKI Gene

mRNA expression in normal human tissues for DGKI Gene

mRNA differential expression in normal tissues according to GTEx for DGKI Gene

This gene is overexpressed in Thyroid (5.8).

Protein differential expression in normal tissues for DGKI Gene

This gene is overexpressed in Fetal Brain (29.0), Neutrophil (12.3), Pancreatic juice (11.6), and Frontal cortex (9.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DGKI Gene

SOURCE GeneReport for Unigene cluster for DGKI Gene Hs.242947

genes like me logo Genes that share expressions with DGKI: view

Expression partners for DGKI Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DGKI Gene

Orthologs for DGKI Gene

This gene was present in the common ancestor of animals.

Orthologs for DGKI Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DGKI 35
  • 92.91 (n)
  • 96.65 (a)
  • 97 (a)
(Canis familiaris)
Mammalia DGKI 35
  • 94.49 (n)
  • 97.92 (a)
  • 96 (a)
(Mus musculus)
Mammalia Dgki 35
  • 90.38 (n)
  • 95.19 (a)
Dgki 16
Dgki 36
  • 93 (a)
(Pan troglodytes)
Mammalia DGKI 35
  • 99.37 (n)
  • 99.34 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Dgki 35
  • 90.45 (n)
  • 95.67 (a)
(Monodelphis domestica)
Mammalia DGKI 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia DGKI 36
  • 88 (a)
(Gallus gallus)
Aves DGKI 35
  • 80.41 (n)
  • 87.18 (a)
  • 82 (a)
(Anolis carolinensis)
Reptilia DGKI 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dgki 35
  • 70.19 (n)
  • 75.65 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16337 35
(Danio rerio)
Actinopterygii dgki 35
  • 69.41 (n)
  • 73.7 (a)
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta rdgA 37
  • 41 (a)
rdgA 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea K06A1.6 37
  • 38 (a)
dgk-5 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
Species with no ortholog for DGKI:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DGKI Gene

Gene Tree for DGKI (if available)
Gene Tree for DGKI (if available)

Paralogs for DGKI Gene

Paralogs for DGKI Gene

(3) SIMAP similar genes for DGKI Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DGKI: view

Variants for DGKI Gene

Sequence variations from dbSNP and Humsavar for DGKI Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs270890 -- 137,696,493(-) GCATT(C/T)AGCTG intron-variant
rs270891 -- 137,648,213(-) TCTGA(A/C)CATCA intron-variant
rs270892 -- 137,683,690(-) ATGGA(G/T)ACTCT intron-variant
rs270893 -- 137,683,201(-) TTTGG(C/G)GGAAA intron-variant
rs1646376 -- 137,553,569(+) GTATT(C/T)AGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DGKI Gene

Variant ID Type Subtype PubMed ID
nsv889235 CNV Loss 21882294
esv33947 CNV Gain 17666407
nsv889242 CNV Loss 21882294
nsv518230 CNV Loss 19592680
esv2735207 CNV Deletion 23290073
esv2224181 CNV Deletion 18987734
esv2735208 CNV Deletion 23290073
nsv520950 CNV Loss 19592680
esv1745681 CNV Insertion 17803354
esv2677586 CNV Deletion 23128226
esv2672944 CNV Deletion 23128226
nsv366883 CNV Loss 16902084
esv2735209 CNV Deletion 23290073
esv270457 CNV Insertion 20981092
nsv464731 CNV Loss 19166990
nsv824315 CNV Loss 20364138
nsv511992 CNV Loss 21212237
esv2428797 CNV Deletion 19546169
esv2735210 CNV Deletion 23290073
esv2031397 CNV Deletion 18987734
esv9134 CNV Loss 19470904
esv2661659 CNV Deletion 23128226
dgv238n6 CNV Loss 16902084
nsv831150 CNV Gain+Loss 17160897
esv2667508 CNV Deletion 23128226

Relevant External Links for DGKI Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGKI Gene

Disorders for DGKI Gene

Relevant External Links for DGKI

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for DGKI Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DGKI Gene

Publications for DGKI Gene

  1. The cloning and characterization of a novel human diacylglycerol kinase, DGK-iota. (PMID: 9830018) Ding L. … Prescott S.M. (J. Biol. Chem. 1998) 2 3 4 23
  2. Evaluation of human diacylglycerol kinase iota, DGKI, a homolog of Drosophila rdgA, in inherited retinopathy mapping to 7q. (PMID: 10706894) Bowne S.J. … Daiger S.P. (Mol. Vis. 2000) 3 4
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk. (PMID: 19065143) Moskvina V. … O'Donovan M.C. (Mol. Psychiatry 2009) 3 48

Products for DGKI Gene

Sources for DGKI Gene

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