Aliases for DGKI Gene
External Ids for DGKI Gene
Previous GeneCards Identifiers for DGKI Gene
This gene is a member of the type IV diacylglycerol kinase subfamily. Diacylglycerol kinases regulate the intracellular concentration of diacylglycerol through its phosphorylation, producing phosphatidic acid. The specific role of the enzyme encoded by this gene is undetermined, however, it may play a crucial role in the production of phosphatidic acid in the retina or in recessive forms of retinal degeneration. [provided by RefSeq, Jul 2008]
GeneCards Summary for DGKI Gene
DGKI (Diacylglycerol Kinase Iota) is a Protein Coding gene. Diseases associated with DGKI include Retinitis Pigmentosa 10. Among its related pathways are Effects of PIP2 hydrolysis and RET signaling. GO annotations related to this gene include NAD+ kinase activity and diacylglycerol kinase activity. An important paralog of this gene is DGKZ.
Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.