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Aliases for DGKH Gene

Aliases for DGKH Gene

  • Diacylglycerol Kinase, Eta 2 3
  • Diglyceride Kinase Eta 3 4
  • DAG Kinase Eta 3 4
  • EC 2.7.1.107 4 63
  • Diacylglycerol Kinase Eta 3
  • DGK-Eta 4
  • DGKeta 3

External Ids for DGKH Gene

Previous GeneCards Identifiers for DGKH Gene

  • GC13U990039
  • GC13P041559
  • GC13P040420
  • GC13P041520
  • GC13P042622
  • GC13P023427

Summaries for DGKH Gene

Entrez Gene Summary for DGKH Gene

  • This gene encodes a member of the diacylglycerol kinase (DGK) enzyme family. Members of this family are involved in regulating intracellular concentrations of diacylglycerol and phosphatidic acid. Variation in this gene has been associated with bipolar disorder. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jul 2014]

GeneCards Summary for DGKH Gene

DGKH (Diacylglycerol Kinase, Eta) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include phospholipid binding and diacylglycerol kinase activity. An important paralog of this gene is DGKI.

UniProtKB/Swiss-Prot for DGKH Gene

  • Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization.

Tocris Summary for DGKH Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes (DGKalpha, DGKbeta, DGKgamma, DGKdelta, DGKepsilon, DGKzeta, DGKeta, DGKtheta, DGKiota and DGKkappa) that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain, two cysteine-rich Zn2+-finger motifs that bind DAG and an ATP-binding site, whilst the regulatory domain varies. DGKs are widely distributed throughout mammalian tissues and different isozymes have different subcellular localizations; some are cytosolic (for example DGKalpha), some are membrane-bound (for example DGKgamma is associated with the Golgi membrane) and some are nuclear (for example DGKzeta. DGKs have diverse biological roles as they participate in signal transduction by modulating levels of DAG in a variety of cellular responses to extracellular stimuli.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGKH Gene

Genomics for DGKH Gene

Regulatory Elements for DGKH Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DGKH Gene

Start:
42,040,036 bp from pter
End:
42,256,578 bp from pter
Size:
216,543 bases
Orientation:
Plus strand

Genomic View for DGKH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DGKH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKH Gene

Proteins for DGKH Gene

  • Protein details for DGKH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XP1-DGKH_HUMAN
    Recommended name:
    Diacylglycerol kinase eta
    Protein Accession:
    Q86XP1
    Secondary Accessions:
    • A2A2W7
    • A6NFX7
    • B4DZ34
    • Q5VZW0
    • Q6PI56
    • Q86XP2
    • Q8N3N0
    • Q8N7J9

    Protein attributes for DGKH Gene

    Size:
    1220 amino acids
    Molecular mass:
    134866 Da
    Quaternary structure:
    • Isoform 1 forms homooligomers through the SAM domain. Isoform 1 is also able to form heterooligomers with SAM domain-containing isoforms of DGKD. Oligomerization of isoform 1 inhibits its catalytic activity. Interacts with RAF1 and BRAF.
    SequenceCaution:
    • Sequence=BAC05280.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DGKH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DGKH Gene

Proteomics data for DGKH Gene at MOPED

Post-translational modifications for DGKH Gene

Other Protein References for DGKH Gene

Domains for DGKH Gene

Gene Families for DGKH Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing
  • SAMD :Sterile alpha motif (SAM) domain containing

Suggested Antigen Peptide Sequences for DGKH Gene

Graphical View of Domain Structure for InterPro Entry

Q86XP1

UniProtKB/Swiss-Prot:

DGKH_HUMAN :
  • Q86XP1
Domain:
  • Contains 1 DAGKc domain.
  • Contains 1 PH domain.
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the eukaryotic diacylglycerol kinase family.
Similarity:
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
genes like me logo Genes that share domains with DGKH: view

Function for DGKH Gene

Molecular function for DGKH Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot Function: Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization.

Enzyme Numbers (IUBMB) for DGKH Gene

Gene Ontology (GO) - Molecular Function for DGKH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003951 NAD+ kinase activity IEA --
GO:0004143 diacylglycerol kinase activity IMP 12810723
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DGKH: view

Phenotypes for DGKH Gene

genes like me logo Genes that share phenotypes with DGKH: view

Animal Model Products

CRISPR Products

miRNA for DGKH Gene

miRTarBase miRNAs that target DGKH

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DGKH Gene

Localization for DGKH Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGKH Gene

Cytoplasm. Cell membrane. Note=Translocated from the cytoplasm to endosomes in response to stress stimuli. Isoform 2 is rapidly relocated back to the cytoplasm upon removal of stress stimuli, whereas isoform 1 exhibits sustained endosomal association. Translocates from the cytoplasm to the cell membrane in the presence of active GTP-bound form of HRAS.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DGKH Gene COMPARTMENTS Subcellular localization image for DGKH gene
Compartment Confidence
endosome 5
plasma membrane 5
nucleus 4
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for DGKH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005768 endosome IDA 12810723
GO:0005886 plasma membrane TAS --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with DGKH: view

Pathways for DGKH Gene

genes like me logo Genes that share pathways with DGKH: view

Interacting Proteins for DGKH Gene

Gene Ontology (GO) - Biological Process for DGKH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IMP 12810723
GO:0007596 blood coagulation TAS --
GO:0016310 phosphorylation IEA --
GO:0030168 platelet activation TAS --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with DGKH: view

Compounds for DGKH Gene

(1) Tocris Compounds for DGKH Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor [627-86-1]

(865) HMDB Compounds for DGKH Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available
genes like me logo Genes that share compounds with DGKH: view

Transcripts for DGKH Gene

Unigene Clusters for DGKH Gene

Diacylglycerol kinase, eta:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DGKH

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DGKH

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DGKH Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - - - -
SP2: - - - - - -
SP3: - -
SP4: - -
SP5:
SP6:

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34a · 34b · 34c · 34d
SP1: - -
SP2: - - -
SP3: -
SP4: -
SP5:
SP6:

Relevant External Links for DGKH Gene

GeneLoc Exon Structure for
DGKH
ECgene alternative splicing isoforms for
DGKH

Expression for DGKH Gene

mRNA expression in normal human tissues for DGKH Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DGKH Gene

SOURCE GeneReport for Unigene cluster for DGKH Gene Hs.733239

mRNA Expression by UniProt/SwissProt for DGKH Gene

Q86XP1-DGKH_HUMAN
Tissue specificity: Isoform 2 is ubiquitously expressed. Isoform 1 is expressed only in testis, kidney and colon.
genes like me logo Genes that share expressions with DGKH: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DGKH Gene

Orthologs for DGKH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DGKH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DGKH 35
  • 99.51 (n)
  • 99.59 (a)
DGKH 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DGKH 35
  • 89.79 (n)
  • 94.82 (a)
DGKH 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DGKH 35
  • 92.08 (n)
  • 95.56 (a)
DGKH 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dgkh 35
  • 86.76 (n)
  • 92.19 (a)
Dgkh 16
Dgkh 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DGKH 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DGKH 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dgkh 35
  • 85.92 (n)
  • 91.3 (a)
chicken
(Gallus gallus)
Aves DGKH 35
  • 80.45 (n)
  • 84.81 (a)
DGKH 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DGKH 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dgkh 35
  • 77.18 (n)
  • 82.59 (a)
zebrafish
(Danio rerio)
Actinopterygii dgkh 35
  • 71.23 (n)
  • 77.89 (a)
dgkh 36
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002226 35
  • 52.97 (n)
  • 52.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34384 35
  • 52.72 (n)
  • 52.66 (a)
CG34384 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dgk-4 36
  • 31 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3334 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2680 36
  • 48 (a)
OneToMany
Species with no ortholog for DGKH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DGKH Gene

ENSEMBL:
Gene Tree for DGKH (if available)
TreeFam:
Gene Tree for DGKH (if available)

Paralogs for DGKH Gene

Paralogs for DGKH Gene

Selected SIMAP similar genes for DGKH Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DGKH: view

Variants for DGKH Gene

Sequence variations from dbSNP and Humsavar for DGKH Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs168329 -- 42,208,876(+) TATAT(A/G)TAGAT intron-variant
rs173213 -- 42,244,882(-) ctgtc(C/G)cccag intron-variant
rs180865 -- 42,247,372(-) acact(G/T)gtagt intron-variant
rs180870 -- 42,219,343(+) AATGA(A/G)GATGA synonymous-codon, reference, nc-transcript-variant
rs192112 -- 42,244,864(-) tgcag(G/T)ggcgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DGKH Gene

Variant ID Type Subtype PubMed ID
nsv832588 CNV Gain 17160897
nsv900014 CNV Loss 21882294
nsv1016 CNV Insertion 18451855
nsv832589 CNV Loss 17160897
esv2661097 CNV Deletion 23128226
nsv510333 CNV Loss 20534489
nsv455866 CNV Loss 19166990
nsv900015 CNV Loss 21882294
esv269439 CNV Insertion 20981092
esv2747310 CNV Deletion 23290073
dgv554e1 CNV Complex 17122850
esv2646739 CNV Deletion 19546169
esv2747311 CNV Deletion 23290073
esv2150531 CNV Deletion 18987734
esv2952 CNV Deletion 18987735
esv2747312 CNV Deletion 23290073
esv1238821 CNV Deletion 17803354
esv2747313 CNV Deletion 23290073
nsv832590 CNV Gain 17160897
nsv519614 CNV Loss 19592680
nsv523454 CNV Loss 19592680
nsv9070 CNV Gain 18304495
nsv819965 CNV Loss 19587683
nsv455867 CNV Loss 19166990

Relevant External Links for DGKH Gene

HapMap Linkage Disequilibrium report
DGKH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGKH Gene

Disorders for DGKH Gene

Relevant External Links for DGKH

Genetic Association Database (GAD)
DGKH
Human Genome Epidemiology (HuGE) Navigator
DGKH
genes like me logo Genes that share disorders with DGKH: view

No data available for UniProtKB/Swiss-Prot for DGKH Gene

Publications for DGKH Gene

  1. Identification and characterization of two splice variants of human diacylglycerol kinase eta. (PMID: 12810723) Murakami T. … Kanoh H. (J. Biol. Chem. 2003) 3 4 23
  2. A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. (PMID: 17486107) Baum A.E. … McMahon F.J. (Mol. Psychiatry 2008) 3 23 48
  3. No association between DGKH and bipolar disorder in a Scandinavian case-control sample. (PMID: 19478689) Tesli M. … Djurovic S. (Psychiatr. Genet. 2009) 3 23 48
  4. Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerization. (PMID: 19710016) Yasuda S. … Sakane F. (J. Biol. Chem. 2009) 3 4 23
  5. Interacting genes in lithium prophylaxis: preliminary results of an exploratory analysis on the role of DGKH and NR1D1 gene polymorphisms in 199 Sardinian bipolar patients. (PMID: 19818381) Manchia M. … Del Zompo M. (Neurosci. Lett. 2009) 3 23 48

Products for DGKH Gene

Sources for DGKH Gene

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