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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DGKH Gene

protein-coding GIFtS: 56
GCID: GC13P042622

diacylglycerol kinase, eta

Explore 4 diseases affiliated with
DGKH via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Diacylglycerol Kinase, Eta¹ ²		DAG Kinase Eta² ³
DGKeta¹ ²		EC 2.7.1.107³ ⁸
Diglyceride Kinase Eta² ³		Diacylglycerol Kinase Eta²
DGK-Eta¹

External Ids:	HGNC: 2854¹	Entrez Gene: 160851²	Ensembl: ENSG00000102780⁷	OMIM: 604071⁵	UniProtKB: Q86XP1³

Export aliases for DGKH gene to outside databases

Previous GC identifers: GC13U990039 GC13P041559 GC13P040420 GC13P041520 GC13P023427

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DGKH:

This gene encodes a member of the diacylglycerol kinase (DGK) enzyme family of proteins, specifically the type II DGK

subfamily. Members of this family are involved in regulating the intracellular concentrations of diacylglycerol and

phosphatidic acid. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this

gene. (provided by RefSeq, Mar 2011)

UniProtKB/Swiss-Prot: DGKH_HUMAN, Q86XP1

Function: Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell

growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and

BRAF from cytoplasm to membranes and their heterodimerization

summary for DGKH:

Diacylglycerol kinases (DGKs) are a group of ten enzymes (DGKalpha, DGKbeta, DGKgamma, DGKdelta, DGKepsilon,

DGKzeta, DGKeta, DGKtheta, DGKiota and DGKkappa) that metabolize 1,2,diacylglycerol (DAG) to produce

phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain, two cysteine-rich

Zn2+-finger motifs that bind DAG and an ATP-binding site, whilst the regulatory domain varies. DGKs are

widely distributed throughout mammalian tissues and different isozymes have different subcellular

localizations; some are cytosolic (for example DGKalpha), some are membrane-bound (for example DGKgamma is

associated with the Golgi membrane) and some are nuclear (for example DGKzeta. DGKs have diverse biological

roles as they participate in signal transduction by modulating levels of DAG in a variety of cellular

responses to extracellular stimuli.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_024524.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DGKH gene promoter:
SRF TBP GATA-3 SRF (504 AA) NF-AT GATA-1 GATA-2 MEF-2A aMEF-2 NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DGKH promoter sequence

Search SABiosciences Chromatin IP Primers for DGKH

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DGKH

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.11 Ensembl cytogenetic band: 13q14.11 HGNC cytogenetic band: 13q13.3

DGKH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DGKH gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P042622: view genomic region (about GC identifiers)

Start:	42,614,176 bp from pter	End:	42,830,714 bp from pter
Size:	216,539 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DGKH_HUMAN, Q86XP1 (See protein sequence)

Recommended Name: Diacylglycerol kinase eta

Size: 1220 amino acids; 134866 Da

Subunit: Isoform 1 forms homooligomers through the SAM domain. Isoform 1 is also able to form heterooligomers with SAM

domain-containing isoforms of DGKD. Oligomerization of isoform 1 inhibits its catalytic activity. Interacts with RAF1

and BRAF

Subcellular location: Cytoplasm. Cell membrane. Note=Translocated from the cytoplasm to endosomes in response to stress

stimuli. Isoform 2 is rapidly relocated back to the cytoplasm upon removal of stress stimuli, whereas isoform 1

exhibits sustained endosomal association. Translocates from the cytoplasm to the cell membrane in the presence of

active GTP-bound form of HRAS

Sequence caution: Sequence=BAC05280.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: A2A2W7 A6NFX7 B4DZ34 Q5VZW0 Q6PI56 Q86XP2 Q8N3N0 Q8N7J9

Alternative splicing: 4 isoforms: Q86XP1-1 Q86XP1-2 Q86XP1-3 Q86XP1-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DGKH: NX_Q86XP1

Post-translational modifications:

Phosphorylated; does not inhibit catalytic activity¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q86XP1

4/16 DME Specific Peptides for DGKH (Q86XP1) (see all 16)

MWYGVLG

MLDRWSI

HHRIAQC

EGNLPVS

DGKH Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001191433.1 NP_001191434.1 NP_001191435.1 NP_690874.2 NP_821077.1

ENSEMBL proteins:

ENSP00000337572 ENSP00000261491 ENSP00000440823 ENSP00000368576 ENSP00000445114

ENSP00000441308

Reactome Protein details: Q86XP1
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005768	endosome	IDA	12810723
GO:0005886	plasma membrane	TAS	--
GO:0031965	nuclear membrane	IDA	--

DGKH for ontologies About GeneDecksing

DGKH Antibody Products:

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	Novus Biologicals DGKH Antibodies
	Search for Antibodies for DGKH at Abcam
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Assay Products for DGKH:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for DGKH
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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DGKH for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR001206 Diacylglycerol_kinase_cat_dom

IPR002219 Prot_Kinase_C-like_PE/DAG-bd

IPR000756 Diacylglycerol_kin_accessory

IPR013761 SAM/pointed

IPR011993 PH_like_dom

Graphical View of Domain Structure for InterPro Entry Q86XP1

ProtoNet protein and cluster: Q86XP1

5 Blocks protein families:

IPB000756 Diacylglycerol kinase accessory domain (presumed)

IPB001660 Sterile alpha motif SAM

IPB001849 Pleckstrin-like

IPB002219 Protein kinase C

IPB011510 Sterile alpha motif homology 2

UniProtKB/Swiss-Prot: DGKH_HUMAN, Q86XP1

Similarity: Belongs to the eukaryotic diacylglycerol kinase family

Similarity: Contains 1 DAGKc domain

Similarity: Contains 1 PH domain

Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers

Similarity: Contains 1 SAM (sterile alpha motif) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DGKH_HUMAN, Q86XP1

Function: Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell

growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and

BRAF from cytoplasm to membranes and their heterodimerization

Catalytic activity: ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate

Enzyme Number (IUBMB): EC 2.7.1.107¹ ²

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		hsa-miR-29a hsa-miR-29c hsa-miR-29b
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGKH

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004143	diacylglycerol kinase activity	IMP	12810723
GO:0005524	ATP binding	IEA	--
GO:0005543	phospholipid binding	IEA	--
GO:0046872	metal ion binding	IEA	--

DGKH for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for DGKH:

Decreased Salmonella enterica

Gemcitabine induced cell-death

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation

1.00

Hemostasis

0.43

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Effects of PIP2 hydrolysis

Effects of PIP2 hydrolysis

1.00

Glycerolipid metabolism

Glycerolipid metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 Reactome Pathways for DGKH (see all 8)

	GPCR downstream signaling
	Hemostasis
	Effects of PIP2 hydrolysis
	Signal Transduction
	Gastrin-CREB signalling pathway via PKC and MAPK

4 Kegg Pathways (Kegg details for DGKH):

	Glycerolipid metabolism
	Glycerophospholipid metabolism
	Metabolic pathways
	Phosphatidylinositol signaling system

DGKH for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DGKH

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/40 Interacting proteins for DGKH (Q86XP1³ ENSP00000337572⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 40)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DGKD	Q16760³, ENSP00000264057⁴	I2D: score=2 STRING: ENSP00000264057
ARRB1	P49407³	I2D: score=1
AGPAT2	ENSP00000360761⁴	STRING: ENSP00000360761
AGPAT4	ENSP00000314036⁴	STRING: ENSP00000314036
CHPT1	ENSP00000229266⁴	STRING: ENSP00000229266

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	IMP	12810723
GO:0007596	blood coagulation	TAS	--
GO:0030168	platelet activation	TAS	--
GO:0035556	intracellular signal transduction	IEA	--
GO:0051259	protein oligomerization	IMP	12810723

DGKH for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EMD Millipore small molecules for DGKH:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for DGKH available from Tocris Bioscience About this table

Compound	Action	CAS #
R 59-022	Diacylglycerol kinase inhibitor; increases PKC activity	[93076-89-2]
Dioctanoylglycol	Diacylglycerol kinase inhibitor	[627-86-1]

10/865 HMDB Compounds for DGKH (see all 865) About this table

Compound	Synonyms	CAS #	PubMed Ids
DG(16:0e/18:0/0:0)	2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)	--	12486725
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
DG(14:0/14:0/0:0)	DAG(14:0/14:0) (see all 9)	--	--
DG(14:0/14:1(9Z)/0:0)	DAG(14:0/14:1) (see all 15)	--	--
DG(14:0/15:0/0:0)	Diacylglycerol(29:0) (see all 9)	--	--
DG(14:0/16:0/0:0)	DAG(30:0) (see all 9)	--	--
DG(14:0/16:1(9Z)/0:0)	DG(30:1) (see all 15)	--	--
DG(14:0/18:0/0:0)	DG(14:0/18:0) (see all 9)	--	--
DG(14:0/18:1(11Z)/0:0)	Diacylglycerol (see all 15)	--	--

Search CenterWatch for drugs/clinical trials and news about DGKH

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DGKH gene (5 alternative transcripts):

NM_001204504.1 NM_001204505.1 NM_001204506.1 NM_152910.4 NM_178009.3

Unigene Cluster for DGKH:

Diacylglycerol kinase, eta

Hs.733239 [show with all ESTs]

Unigene Representative Sequence: NM_178009

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000337343 ENST00000261491(uc010tfh.2 uc001uym.2) ENST00000498255(uc001uyp.3)

ENST00000489851 ENST00000540693 ENST00000379274(uc001uyl.2 uc001uyo.2 uc010tfj.2)

ENST00000536612(uc001uyn.2 uc010tfi.2) ENST00000538674

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		hsa-miR-29a hsa-miR-29c hsa-miR-29b
		SwitchGear 3'UTR luciferase reporter plasmid: DGKH 3' UTR sequence

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Additional cDNA sequence:

AB078967.1 AB078968.1 AK098302.1 AK122909.1 AK289546.1 AK302631.1 AK302727.1 AL833883.1

BC043292.2

9 DOTS entries:

DT.75100201 DT.100016784 DT.92059912 DT.100776231 DT.120789752 DT.91830864 DT.95306393 DT.455566

DT.91751931

22 AceView cDNA sequences:

BU101575 AI333565 AI382581 BE715967 BG723110 AA722077 AW052032 BV178988

BX955520 BI562169 AB078967 BC043292 AB078968 AI333566 N57320 BE087080

BU101813 NM_178009 NM_152910 N32224 AK122909 N32231

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DGKH (see all 6) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^
SP1:									-		-		-		-		-		-
SP2:									-		-		-		-		-		-
SP3:																	-		-
SP4:																	-		-
SP5:

ExUns:	22	^	23	^	24	^	25	^	26	^	27	^	28	^	29	^	30	^	31	^	32a	·	32b	^	33	^	34a	·	34b	·	34c	·	34d
SP1:																					-				-
SP2:																					-		-		-
SP3:																					-
SP4:																									-
SP5:

ECgene alternative splicing isoforms for DGKH

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DGKH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCAAATATA

About this image
See DGKH Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DGKH

SOURCE GeneReport for Unigene cluster: Hs.733239

UniProtKB/Swiss-Prot: DGKH_HUMAN, Q86XP1

Tissue specificity: Isoform 2 is ubiquitously expressed. Isoform 1 is expressed only in testis, kidney and colon

SABiosciences Custom PCR Arrays for DGKH

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for DGKH gene from 7/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DGKH¹	diacylglycerol kinase, eta	80.1(n) 84.36(a)		769506 XM_001232790.1 XP_001232791.1
lizard (Anolis carolinensis)	Reptilia	DGKH⁶	--	79(a)	1 ↔ 1	3(70270166-70329685)
zebrafish (Danio rerio)	Actinopterygii	dgkh¹	diacylglycerol kinase, eta	73.74(n) 82.95(a)		100137124 NM_001114721.1 NP_001108193.1
fruit fly (Drosophila melanogaster)	Insecta	CG34384¹	CG34384	52.15(n) 51.49(a)		5740362 NM_001104234.4 NP_001097704.1
worm (Caenorhabditis elegans)	Secernentea	dgk-4⁶	--	27(a)	1 → many	IV(8631321-8643991)
thale cress (Arabidopsis thaliana)	eudicotyledons	DGK2⁶ DGK1⁶ (see all 7)	diacylglycerol kinase1 (see all 7)	26(a) 25(a) (see all 7)	many ↔ many many ↔ many (see all 7)	5(25518641-25523621) 5(2524778-2529330)
rice (Oryza sativa)	Liliopsida	-- -- (see all 8)	diacylglycerol kinase 1, putative, expressed (see all 8)	26(a) 25(a) (see all 8)	many ↔ many many ↔ many (see all 8)	12(6728516-6733263) 3(17753599-17759915)

ENSEMBL Gene Tree for DGKH (if available)
TreeFam Gene Tree for DGKH (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DGKH gene

DGKA² DGKQ² DGKG² DGKB² DGKD² DGKI² DGKE² DGKZ²

3 SIMAP similar genes for DGKH using alignment to 2 protein entries: DGKH_HUMAN (see all proteins):

DGKD DGKK DGKA

DGKH for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78485730^1,2		--	23415028(+)	`AAGCCG/ACAAAA`	1	--	us2k¹		1	CSA	2
rs73185402^1,2	C,F,	--	23415047(+)	`ACTCAA/GGGTAC`	1	--	us2k¹		2	NA EA	240
rs73187203^1,2	C,F,	--	23415097(+)	`NNNNTG/ATCAGG`	1	--	us2k¹		2	NA EA	240
rs117218662^1,2	C,F,	--	23415924(+)	`AAGTTC/TGTTTT`	1	--	us2k¹		1	NA	120
rs76281546^1,2		--	23416682(+)	`GATGGC/TATGAT`	1	--	us2k¹		1	WA	118
rs73468973^1,2	C,F,	--	23416737(+)	`GGAGGG/AGGAGT`	1	--	us2k¹		5	WA NA EA	362
rs74915082^1,2	C,	--	23416738(+)	`GAGGGG/AGAGTA`	1	--	us2k¹		2	CSA WA	120
rs113487034^1,2		--	23416974(+)	`GCACGC/TCCTCA`	1	--	us2k¹		1	CSA	2
rs113362476^1,2		--	23417071(+)	`GAGCGC/TAGCTG`	1	--	ut5¹		1	CSA	2
rs9594663^1,2		--	23417083(+)	`AGTGCG/AGCTGA`	1	--	ut5¹		2	CSA WA	120

HapMap Linkage Disequilibrium report for DGKH (42614176 - 42830714 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for DGKH
5 CNVs: 49211 101716 3011 30636 86810
4 Indels: 42610 25247 58626 45168

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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DGKH for disorders           About GeneDecksing

OMIM gene information: 604071    OMIM disorders: --

4 diseases for DGKH:    About MalaCards

bipolar disorder measles schizophrenia neuronitis

Human Genome Epidemiology (HuGE) Navigator: DGKH (7 documents)

Export disorders for DGKH gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DGKH gene, integrated from 9 sources (see all 27):
(articles sorted by number of sources associating them with DGKH)

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Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerization. (PubMed id 19710016)^{1, 2, 9} Yasuda S....Sakane F. (2009)
Identification and characterization of two splice variants of human diacylglycerol kinase eta. (PubMed id 12810723)^{1, 2, 9} Murakami T.... Kanoh H. (2003)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{1, 2} Dunham A.... Ross M.T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Cloning and characterization of a glucocorticoid-induced diacylglycerol kinase. (PubMed id 8702685)^{1, 3} Klauck T.M....Jaken S. (1996)
A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. (PubMed id 17486107)^{1, 9} Baum A.E....McMahon F.J. (2008)
No association between DGKH and bipolar disorder in a Scandinavian case-control sample. (PubMed id 19478689)^{1, 9} Tesli M....Djurovic S. (2009)
Interacting genes in lithium prophylaxis: preliminary results of an exploratory analysis on the role of DGKH and NR1D1 gene polymorp hisms in 199 Sardinian bipolar patients. (PubMed id 19818381)^{1, 9} Manchia M....Del Zompo M. (2009)
Diacylglycerol kinase K variants impact hypospadias in a California study population. (PubMed id 23177175)¹ Carmichael S.L....Lammer E.J. (2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 160851	HGNC: 2854	AceView: DGKH	Ensembl:ENSG00000102780	euGenes: HUgn160851
ECgene: DGKH	Kegg: 160851	H-InvDB: DGKH

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DGKH	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DGKH gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DGKH gene:
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GeneCards and IP:
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