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Aliases for DGKG Gene

Aliases for DGKG Gene

  • Diacylglycerol Kinase, Gamma 90kDa 2 3
  • DAGK3 3 4 6
  • Diglyceride Kinase Gamma 3 4
  • DAG Kinase Gamma 3 4
  • EC 2.7.1.107 4 64
  • DGK-GAMMA 3 4
  • Diacylglycerol Kinase, Gamma (90kD) 2
  • Diacylglycerol Kinase Gamma 3
  • Diacylglyerol Kinase Gamma 3

External Ids for DGKG Gene

Previous Symbols for DGKG Gene

  • DAGK3

Summaries for DGKG Gene

Entrez Gene Summary for DGKG Gene

  • This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DGKG Gene

DGKG (Diacylglycerol Kinase, Gamma 90kDa) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include calcium ion binding and diacylglycerol kinase activity. An important paralog of this gene is DGKI.

UniProtKB/Swiss-Prot for DGKG Gene

  • Reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to phosphatidic acid

Tocris Summary for DGKG Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes (DGKalpha, DGKbeta, DGKgamma, DGKdelta, DGKepsilon, DGKzeta, DGKeta, DGKtheta, DGKiota and DGKkappa) that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C-terminal catalytic domain, two cysteine-rich Zn2+-finger motifs that bind DAG and an ATP-binding site, whilst the regulatory domain varies. DGKs are widely distributed throughout mammalian tissues and different isozymes have different subcellular localizations; some are cytosolic (for example DGKalpha), some are membrane-bound (for example DGKgamma is associated with the Golgi membrane) and some are nuclear (for example DGKzeta. DGKs have diverse biological roles as they participate in signal transduction by modulating levels of DAG in a variety of cellular responses to extracellular stimuli.

Gene Wiki entry for DGKG Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGKG Gene

Genomics for DGKG Gene

Genomic Location for DGKG Gene

Start:
186,105,668 bp from pter
End:
186,362,237 bp from pter
Size:
256,570 bases
Orientation:
Minus strand

Genomic View for DGKG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DGKG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKG Gene

Regulatory Elements for DGKG Gene

Proteins for DGKG Gene

  • Protein details for DGKG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49619-DGKG_HUMAN
    Recommended name:
    Diacylglycerol kinase gamma
    Protein Accession:
    P49619
    Secondary Accessions:
    • B2RAH4
    • Q2M1H4
    • Q5FWG1

    Protein attributes for DGKG Gene

    Size:
    791 amino acids
    Molecular mass:
    89124 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DGKG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DGKG Gene

Proteomics data for DGKG Gene at MOPED

Post-translational modifications for DGKG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DGKG Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for DGKG Gene

Gene Families for DGKG Gene

HGNC:
  • EFHAND :EF-hand domain containing

UniProtKB/Swiss-Prot:

DGKG_HUMAN
Domain:
  • Contains 1 DAGKc domain.:
    • P49619
  • Contains 2 EF-hand domains.:
    • P49619
Family:
  • Belongs to the eukaryotic diacylglycerol kinase family.:
    • P49619
Similarity:
  • Contains 2 phorbol-ester/DAG-type zinc fingers.:
    • P49619
genes like me logo Genes that share domains with DGKG: view

Function for DGKG Gene

Molecular function for DGKG Gene

GENATLAS Biochemistry: diacylglycerol kinase gamma,90kDa,predominantly expressed in the retina and brain
UniProtKB/Swiss-Prot CatalyticActivity: ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Requires phosphatidylserine for maximal activity
UniProtKB/Swiss-Prot Function: Reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to phosphatidic acid

Enzyme Numbers (IUBMB) for DGKG Gene

Gene Ontology (GO) - Molecular Function for DGKG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003951 NAD+ kinase activity IEA --
GO:0004143 diacylglycerol kinase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005524 ATP binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with DGKG: view

Phenotypes for DGKG Gene

GenomeRNAi human phenotypes for DGKG:
genes like me logo Genes that share phenotypes with DGKG: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DGKG Gene

Localization for DGKG Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGKG Gene

Cytoplasm. Membrane. Note=Can be loosely bound to the membranes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DGKG Gene COMPARTMENTS Subcellular localization image for DGKG gene
Compartment Confidence
plasma membrane 4
cytosol 3
golgi apparatus 2
nucleus 2

Gene Ontology (GO) - Cellular Components for DGKG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with DGKG: view

Pathways for DGKG Gene

genes like me logo Genes that share pathways with DGKG: view

Interacting Proteins for DGKG Gene

Gene Ontology (GO) - Biological Process for DGKG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 8034597
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0007596 blood coagulation TAS --
GO:0016310 phosphorylation IEA --
GO:0030168 platelet activation TAS --
genes like me logo Genes that share ontologies with DGKG: view

Compounds for DGKG Gene

(1) Tocris Compounds for DGKG Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor [627-86-1]

(979) HMDB Compounds for DGKG Gene

Compound Synonyms Cas Number PubMed IDs
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available
DG(14:0/16:0/0:0)
  • DAG(30:0)
Not Available
DG(14:0/16:1(9Z)/0:0)
  • DG(30:1)
Not Available

(1) Drugbank Compounds for DGKG Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Phosphatidylserine
  • 3-O-sn-Phosphatidyl-L-serine
8002-43-5 target
genes like me logo Genes that share compounds with DGKG: view

Transcripts for DGKG Gene

Unigene Clusters for DGKG Gene

Diacylglycerol kinase, gamma 90kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DGKG Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - -
SP2: - - -
SP3: - - - -
SP4:

ExUns: 24 ^ 25 ^ 26a · 26b ^ 27
SP1: -
SP2:
SP3: -
SP4:

Relevant External Links for DGKG Gene

GeneLoc Exon Structure for
DGKG
ECgene alternative splicing isoforms for
DGKG

Expression for DGKG Gene

mRNA expression in normal human tissues for DGKG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DGKG Gene

This gene is overexpressed in Brain - Cerebellum (5.5), Brain - Cerebellar Hemisphere (5.4), Esophagus - Muscularis (5.2), and Esophagus - Gastroesophageal Junction (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DGKG Gene

SOURCE GeneReport for Unigene cluster for DGKG Gene Hs.683449

mRNA Expression by UniProt/SwissProt for DGKG Gene

P49619-DGKG_HUMAN
Tissue specificity: Predominantly expressed in retina and in a much lesser extent in the brain. Other tissues contain extremely low levels of DGK-gamma
genes like me logo Genes that share expressions with DGKG: view

Orthologs for DGKG Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DGKG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DGKG 36
  • 99.58 (n)
  • 99.49 (a)
DGKG 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DGKG 36
  • 91.49 (n)
  • 92.03 (a)
DGKG 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DGKG 36
  • 91.39 (n)
  • 94.05 (a)
DGKG 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dgkg 36
  • 87.77 (n)
  • 89.97 (a)
Dgkg 16
Dgkg 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DGKG 37
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dgkg 36
  • 87.18 (n)
  • 88.58 (a)
chicken
(Gallus gallus)
Aves DGKG 36
  • 70.88 (n)
  • 69.8 (a)
DGKG 37
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DGKG 37
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii DGKG 37
  • 58 (a)
OneToOne
LOC567728 36
  • 66.03 (n)
  • 67.17 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dgk 37
  • 31 (a)
OneToMany
Dgk 38
  • 55 (a)
worm
(Caenorhabditis elegans)
Secernentea dgk-3 37
  • 46 (a)
OneToMany
dgk-3 38
  • 45 (a)
rice
(Oryza sativa)
Liliopsida Os03g0425300 36
  • 50.58 (n)
  • 45.14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10986 37
  • 49 (a)
OneToMany
Species with no ortholog for DGKG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DGKG Gene

ENSEMBL:
Gene Tree for DGKG (if available)
TreeFam:
Gene Tree for DGKG (if available)

Paralogs for DGKG Gene

Paralogs for DGKG Gene

Selected SIMAP similar genes for DGKG Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DGKG: view

Variants for DGKG Gene

Sequence variations from dbSNP and Humsavar for DGKG Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2574 -- 186,149,761(-) ATCCC(C/G)CTTTC utr-variant-3-prime
rs2575 -- 186,149,602(-) GCCTC(C/T)GGCTC utr-variant-3-prime
rs710443 -- 186,288,777(-) GTGGT(A/C/G)TACCT reference, synonymous-codon
rs725442 -- 186,227,558(-) ATTAT(C/T)TCACA intron-variant
rs725443 -- 186,227,082(-) CCTCT(A/G)TAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DGKG Gene

Variant ID Type Subtype PubMed ID
nsv822367 CNV Loss 20364138
esv2664472 CNV Deletion 23128226
nsv820248 CNV Loss 19587683
nsv4150 CNV Insertion 18451855
nsv878067 CNV Gain 21882294
esv2726335 CNV Deletion 23290073
esv2726336 CNV Deletion 23290073
esv1567505 CNV Insertion 17803354
esv268182 CNV Insertion 20981092

Relevant External Links for DGKG Gene

HapMap Linkage Disequilibrium report
DGKG

Disorders for DGKG Gene

Relevant External Links for DGKG

Genetic Association Database (GAD)
DGKG
Human Genome Epidemiology (HuGE) Navigator
DGKG
genes like me logo Genes that share disorders with DGKG: view

No data available for UniProtKB/Swiss-Prot for DGKG Gene

Publications for DGKG Gene

  1. Molecular cloning of a diacylglycerol kinase isozyme predominantly expressed in human retina with a truncated and inactive enzyme expression in most other human cells. (PMID: 8034597) Kai M. … Kanoh H. (J. Biol. Chem. 1994) 2 3 4 23
  2. Mapping and genomic characterization of the gene encoding diacylglycerol kinase gamma (DAGK3): assessment of its role in dominant optic atrophy (OPA1). (PMID: 10071200) Stoehr H. … Weber B.H.F. (Hum. Genet. 1999) 3 4 23
  3. Phosphorylation and up-regulation of diacylglycerol kinase gamma via its interaction with protein kinase C gamma. (PMID: 16905533) Yamaguchi Y. … Saito N. (J. Biol. Chem. 2006) 3 23 25
  4. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. (PMID: 19079260) Thorleifsson G. … Stefansson K. (Nat. Genet. 2009) 3 49
  5. Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese. (PMID: 20215397) Ng M.C. … Ma R.C. (J. Clin. Endocrinol. Metab. 2010) 3 49

Products for DGKG Gene

  • Addgene plasmids for DGKG

Sources for DGKG Gene

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