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DGKG Gene

protein-coding   GIFtS: 63
GCID: GC03M185823

Diacylglycerol Kinase, Gamma 90kDa

(Previous names: diacylglycerol kinase, gamma (90kD))
(Previous symbol: DAGK3)
  See DGKG-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Diacylglycerol Kinase, Gamma 90kDa1 2     Diacylglycerol Kinase, Gamma (90kD)1
DAGK31 2 3 5     DGK-GAMMA2
Diglyceride Kinase Gamma2 3     Diacylglycerol Kinase Gamma2
DAG Kinase Gamma2 3     Diacylglyerol Kinase Gamma2
EC 2.7.1.1073 8     DGK-gamma3

External Ids:    HGNC: 28531   Entrez Gene: 16082   Ensembl: ENSG000000588667   OMIM: 6018545   UniProtKB: P496193   

Export aliases for DGKG gene to outside databases

Previous GC identifers: GC03M182638 GC03M187124 GC03M187269 GC03M187187 GC03M187349 GC03M183274


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DGKG Gene:
This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved
in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of
diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C
isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol
kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage
differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for DGKG Gene:
DGKG (diacylglycerol kinase, gamma 90kDa) is a protein-coding gene. Diseases associated with DGKG include dominant optic atrophy. GO annotations related to this gene include diacylglycerol kinase activity and calcium ion binding. An important paralog of this gene is DGKH.

UniProtKB/Swiss-Prot: DGKG_HUMAN, P49619
Function: Reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to
phosphatidic acid

summary for DGKG Gene:
Diacylglycerol kinases (DGKs) are a group of ten enzymes (DGKalpha, DGKbeta, DGKgamma, DGKdelta, DGKepsilon,
DGKzeta, DGKeta, DGKtheta, DGKiota and DGKkappa) that metabolize 1,2,diacylglycerol (DAG) to produce
phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain, two cysteine-rich
Zn2+-finger motifs that bind DAG and an ATP-binding site, whilst the regulatory domain varies. DGKs are
widely distributed throughout mammalian tissues and different isozymes have different subcellular
localizations; some are cytosolic (for example DGKalpha), some are membrane-bound (for example DGKgamma is
associated with the Golgi membrane) and some are nuclear (for example DGKzeta. DGKs have diverse biological
roles as they participate in signal transduction by modulating levels of DAG in a variety of cellular
responses to extracellular stimuli.

Gene Wiki entry for DGKG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the DGKG gene promoter:
         RFX1   AML1a   NRSF form 1   XBP-1   Nkx2-5   Tal-1beta   NRSF form 2   Evi-1   ITF-2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDGKG promoter sequence
   Search Chromatin IP Primers for DGKG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DGKG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27.2-q27.3   Ensembl cytogenetic band:  3q27.3   HGNC cytogenetic band: 3q27-q28

DGKG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DGKG gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M185823:  view genomic region     (about GC identifiers)

Start:
185,823,457 bp from pter      End:
186,080,026 bp from pter
Size:
256,570 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DGKG_HUMAN, P49619 (See protein sequence)
Recommended Name: Diacylglycerol kinase gamma  
Size: 791 amino acids; 89124 Da
Secondary accessions: B2RAH4 Q2M1H4 Q5FWG1
Alternative splicing: 3 isoforms:  P49619-1   P49619-2   P49619-3   (May be inactive)

Explore the universe of human proteins at neXtProt for DGKG: NX_P49619

Explore proteomics data for DGKG at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DGKG (P49619) (see all 11)
     PMQVDGE  VNPKSGG  PLLVLLG  TSETFAA 


    See DGKG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001074213.1  NP_001074214.1  NP_001337.2  

    ENSEMBL proteins: 
     ENSP00000265022   ENSP00000339777   ENSP00000371599   ENSP00000395526   ENSP00000440507  
    Reactome Protein details: P49619

    DGKG Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for DGKG 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    Selected InterPro protein domains (see all 7):
     IPR001206 Diacylglycerol_kinase_cat_dom
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR000756 Diacylglycerol_kin_accessory
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry P49619

    ProtoNet protein and cluster: P49619

    1 Blocks protein domain: IPB000756 Diacylglycerol kinase accessory domain (presumed)

    UniProtKB/Swiss-Prot: DGKG_HUMAN, P49619
    Similarity: Belongs to the eukaryotic diacylglycerol kinase family
    Similarity: Contains 1 DAGKc domain
    Similarity: Contains 2 EF-hand domains
    Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers


    Find genes that share domains with DGKG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DGKG_HUMAN, P49619
    Function: Reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to
    phosphatidic acid
    Catalytic activity: ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate
    Enzyme regulation: Requires phosphatidylserine for maximal activity

         Genatlas biochemistry entry for DGKG:
    diacylglycerol kinase gamma,90kDa,predominantly expressed in the retina and brain

         Enzyme Number (IUBMB): EC 2.7.1.1071 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003951NAD+ kinase activity IEA--
    GO:0004143diacylglycerol kinase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005524ATP binding IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with DGKG           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DGKG:
     Decreased mitotic index 

         1 MGI phenotypic allele for Dgkg (no phenotypes)

    Find genes that share phenotypes with DGKG           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DGKG
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DGKG
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    Selected qRT-PCR Assays for microRNAs that regulate DGKG (see all 47):
    hsa-miR-124* hsa-miR-3607-3p hsa-miR-330-5p hsa-miR-146a hsa-miR-605 hsa-miR-346 hsa-miR-3921 hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidDGKG 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for DGKG
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DGKG
    Addgene plasmids for DGKG 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGKG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DGKG_HUMAN, P49619: Cytoplasm. Membrane. Note=Can be loosely bound to the membranes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol3
    golgi apparatus2
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with DGKG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DGKG About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    3Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    4Glycerophospholipid biosynthesis
    Glycerophospholipid metabolism0.62
    5Inositol phosphate metabolism (KEGG)
    Phosphatidylinositol signaling system0.61


    Find genes that share SuperPaths with DGKG           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for DGKG
        Effects of PIP2 hydrolysis


    4 Kegg Pathways  (Kegg details for DGKG):
        Glycerolipid metabolism
    Glycerophospholipid metabolism
    Metabolic pathways
    Phosphatidylinositol signaling system

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DGKG
    Interactions:

        Search GeneGlobe Interaction Network for DGKG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DGKG (P496193 ENSP000002650224) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    ARRB1P494073I2D: score=1 
    AGPAT2ENSP000003607614STRING: ENSP00000360761
    AGPAT4ENSP000003140364STRING: ENSP00000314036
    CAP1ENSP000003618784STRING: ENSP00000361878
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS8034597
    GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway IEA--
    GO:0007596blood coagulation TAS--
    GO:0030168platelet activation TAS--
    GO:0035556intracellular signal transduction IEA--

    Find genes that share ontologies with DGKG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for DGKG available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DioctanoylglycolDiacylglycerol kinase inhibitor[627-86-1]

    Selected HMDB Compounds for DGKG (see all 979)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----

    1 DrugBank Compound for DGKG    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Phosphatidylserine3-O-sn-Phosphatidyl-L-serine (see all 3)8002-43-5target--16905533



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DGKG gene (3 alternative transcripts): 
    NM_001080744.1  NM_001080745.1  NM_001346.2  

    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447054 ENST00000265022(uc003fqa.3 uc003fqb.3 uc003fqc.3 uc011brx.2)
    ENST00000344484 ENST00000382164 ENST00000490452 ENST00000480809 ENST00000480933
    ENST00000472506 ENST00000437018 ENST00000482566 ENST00000466466 ENST00000544847

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    Selected qRT-PCR Assays for microRNAs that regulate DGKG (see all 47):
    hsa-miR-124* hsa-miR-3607-3p hsa-miR-330-5p hsa-miR-146a hsa-miR-605 hsa-miR-346 hsa-miR-3921 hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidDGKG 3' UTR sequence
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    Selected AceView cDNA sequences (see all 53):

    BI038311 BM669549 CA391741 AW770587 BE468027 BQ898097 BX954094 AI911283 
    AL598473 D26135 BQ549212 BQ879937 BX505681 CD365475 AI418168 AV707323 
    BF792878 AA933006 AW014722 AI681741 T16476 BF223746 BM673524 BQ440190 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DGKG    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:                                                        -                 -                                                                             -   
    SP2:                                                        -                 -                 -                                                               
    SP3:                                                        -                 -                                         -                                   -   
    SP4:                                                                                                                                                            

    ExUns: 24 ^ 25 ^ 26a · 26b ^ 27
    SP1:                    -         
    SP2:                              
    SP3:                    -         
    SP4:                              


    ECgene alternative splicing isoforms for DGKG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    DGKG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTCTACCCC
    DGKG Expression
    About this image


    DGKG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Eye (Sensory Organs)
             Retina
    DGKG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DGKG Protein Expression

    UniProtKB/Swiss-Prot: DGKG_HUMAN, P49619
    Tissue specificity: Predominantly expressed in retina and in a much lesser extent in the brain. Other tissues
    contain extremely low levels of DGK-gamma

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGKG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DGKG gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dgkg1 , 5 diacylglycerol kinase, gamma1, 5 87.77(n)1
    89.97(a)1
      16 (13.37 cM)5
    1101971  NM_138650.21  NP_619591.11 
     224684615 
    chicken
    (Gallus gallus)
    Aves DGKG1 diacylglycerol kinase, gamma 90kDa 70.88(n)
    69.8(a)
      424839  XM_422650.4  XP_422650.4 
    lizard
    (Anolis carolinensis)
    Reptilia DGKG6
    diacylglycerol kinase, gamma 90kDa
    57(a)
    1 ↔ 1
    3(33992501-34166740)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5677281 diacylglycerol kinase beta-like 66.03(n)
    67.17(a)
      567728  XM_691028.6  XP_696120.6 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dgk3 phosphatidylinositol biosynthesis
    diacylglycerol more
    55(a)   43E18   --
    worm
    (Caenorhabditis elegans)
    Secernentea dgk-33 Diacylglycerol kinase 45(a)   III(9234802-9239752)   --
    rice
    (Oryza sativa)
    Liliopsida Os03g04253001 Os03g0425300 50.58(n)
    45.14(a)
      9266342  NM_001186551.1  NP_001173480.1 


    ENSEMBL Gene Tree for DGKG (if available)
    TreeFam Gene Tree for DGKG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DGKG gene
    DGKH2  DGKQ2  DGKB2  DGKI2  DGKE2  DGKZ2  DGKA2  DGKD2  
    4 SIMAP similar genes for DGKG using alignment to 4 protein entries:     DGKG_HUMAN (see all proteins):
    DGKB    DAGK1    DGKA    PRKCH

    Find genes that share paralogs with DGKG           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DGKG (see all 4626)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361194
    A breast cancer sample4--see VAR_0361192 E K mis40--------
    rs1433558491,2
    --185864628(+) AGTGGG/TTCTCT 3 -- ds50010--------
    rs1134360931,2
    C,F--185864747(+) TGTAAC/TGCCAG 3 -- ds50011Minor allele frequency- T:0.50NA 2
    rs1475263551,2
    --185864809(+) TTTAAC/TGTATC 3 -- ds50010--------
    rs1403022431,2
    --185864893(+) ATCTCC/TACTCT 3 -- ds50010--------
    rs1492383821,2
    --185865025(+) GGTAGA/GAGCAT 3 -- ut310--------
    rs32050271,2
    H--185865083(-) TATTTC/TTTATC 3 -- ut314Minor allele frequency- T:0.01MN EA NS 474
    rs1885601441,2
    --185865085(+) TAAGAA/TATAAG 3 -- ut310--------
    rs1816049821,2
    --185865198(+) CTAACC/TTCAGA 3 -- ut310--------
    rs730661511,2
    C--185865215(+) TATGAG/AGGTCA 3 -- ut312Minor allele frequency- A:0.04WA 120

    HapMap Linkage Disequilibrium report for DGKG (185823457 - 186073457 bp, first 250kb of DGKG)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for DGKG:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2726335CNV Deletion23290073
    esv2664472CNV Deletion23128226
    esv2726336CNV Deletion23290073
    esv1567505CNV Insertion17803354
    nsv4150CNV Insertion18451855
    esv268182CNV Insertion20981092
    nsv820248CNV Loss19587683
    nsv822367CNV Loss20364138
    nsv878067CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DGKG
    DNA2.0 Custom Variant and Variant Library Synthesis for DGKG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601854    OMIM disorders: --

    1 disease for DGKG:    
    About MalaCards
    dominant optic atrophy


    Find genes that share disorders with DGKG           About GenesLikeMe

    Genetic Association Database (GAD): DGKG
    Human Genome Epidemiology (HuGE) Navigator: DGKG (5 documents)

    Export disorders for DGKG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DGKG gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with DGKG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a diacylglycerol kinase isozyme predominantly expressed in human retina with a truncated and inactive enzyme expression in most other human cells. (PubMed id 8034597)1, 2, 3, 9 Kai M.... Kanoh H. (J. Biol. Chem. 1994)
    2. Phosphorylation and up-regulation of diacylglycerol kinase gamma via its interaction with protein kinase C gamma. (PubMed id 16905533)1, 7, 9 Yamaguchi Y....Saito N. (J. Biol. Chem. 2006)
    3. Mapping and genomic characterization of the gene encoding diacylglycerol kinase gamma (DAGK3): assessment of its role in dominant optic atrophy (OPA1). (PubMed id 10071200)1, 2, 9 Stoehr H.... Weber B.H.F. (Hum. Genet. 1999)
    4. Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese. (PubMed id 20215397)1, 4 Ng M.C....Ma R.C. (J. Clin. Endocrinol. Metab. 2010)
    5. Analyses of shared genetic factors between asthma and obesity in children. (PubMed id 20816195)1, 4 MelAcn E....Lasky-Su J. (J. Allergy Clin. Immunol. 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. (PubMed id 19079260)1, 4 Thorleifsson G....Stefansson K. (Nat. Genet. 2009)
    8. Phorbol ester and hydrogen peroxide synergistically induce the interaction of diacylglycerol kinase gamma with the Src homology 2 and C1 domains of beta2-chimaerin. (PubMed id 17803461)1, 9 Yasuda S....Sakane F. (Biochem. J. 2008)
    9. Nuclear transportation of diacylglycerol kinase gamma and its possible function in the nucleus. (PubMed id 16407189)1, 9 Matsubara T....Saito N. (J. Biol. Chem. 2006)
    10. Diacylglycerol kinase gamma serves as an upstream suppressor of Rac1 and lamellipodium formation. (PubMed id 15102830)1, 9 Tsushima S....Sakane F. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1608 HGNC: 2853 AceView: DGKG Ensembl:ENSG00000058866 euGenes: HUgn1608
    ECgene: DGKG Kegg: 1608 H-InvDB: DGKG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DGKG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DGKG Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DGKG gene:
    Search GeneIP for patents involving DGKG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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