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Aliases for DGKE Gene

Aliases for DGKE Gene

  • Diacylglycerol Kinase Epsilon 2 3 5
  • Diacylglycerol Kinase, Epsilon 64kDa 2 3
  • Diglyceride Kinase Epsilon 3 4
  • DAG Kinase Epsilon 3 4
  • EC 2.7.1.107 4 61
  • DGK-Epsilon 3 4
  • DAGK5 3 4
  • Diacylglycerol Kinase, Epsilon (64kD) 2
  • AHUS7 3
  • DAGK6 3
  • NPHS7 3
  • DGK 3

External Ids for DGKE Gene

Previous GeneCards Identifiers for DGKE Gene

  • GC17P054648
  • GC17P057392
  • GC17P055253
  • GC17P055386
  • GC17P052266
  • GC17P054911
  • GC17P050271

Summaries for DGKE Gene

Entrez Gene Summary for DGKE Gene

  • Diacylglycerol kinases are thought to be involved mainly in the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. When expressed in mammalian cells, DGK-epsilon shows specificity for arachidonyl-containing diacylglycerol. DGK-epsilon is expressed predominantly in testis. [provided by RefSeq, Jul 2008]

GeneCards Summary for DGKE Gene

DGKE (Diacylglycerol Kinase Epsilon) is a Protein Coding gene. Diseases associated with DGKE include Nephrotic Syndrome, Type 7 and Hemolytic-Uremic Syndrome. Among its related pathways are Effects of PIP2 hydrolysis and RET signaling. GO annotations related to this gene include NAD+ kinase activity and diacylglycerol kinase activity. An important paralog of this gene is DGKQ.

UniProtKB/Swiss-Prot for DGKE Gene

  • Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition.

Tocris Summary for DGKE Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGKE Gene

Genomics for DGKE Gene

Regulatory Elements for DGKE Gene

Enhancers for DGKE Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G057460 1.9 FANTOM5 Ensembl ENCODE dbSUPER 20.5 +629.4 629438 6.7 HDGF PKNOX1 ZNF493 WRNIP1 ZFP64 ZBTB7B YY1 ZNF121 GATA2 ZNF207 SRSF1 COIL ENSG00000262298 DGKE MSI2 VEZF1 DYNLL2 ENSG00000279281 LOC101927557
GH17G056832 1.1 ENCODE 18.9 -0.1 -88 3.3 HDGF PKNOX1 MLX ARNT CREB3L1 AGO1 WRNIP1 ARID4B SIN3A YBX1 DGKE C17orf67 PIR41486
GH17G057541 1.8 VISTA Ensembl ENCODE dbSUPER 10.6 +707.9 707924 1.6 PKNOX1 ATF1 SIN3A FEZF1 ZNF2 ZNF263 SP3 JUNB TSHZ1 REST DGKE ENSG00000280028 LOC101927539
GH17G056697 1.2 Ensembl ENCODE 14.5 -135.1 -135086 3.2 TBP PKNOX1 NFIB SIN3A ZBTB40 GTF3C2 ZNF766 POLR3A GATA2 ZNF366 DGKE ENSG00000262298 NOG GC17M056726 GC17P056602
GH17G057648 1.2 ENCODE dbSUPER 12.9 +816.1 816104 3.1 HDGF PKNOX1 FOXA2 ARNT SIN3A YBX1 TCF12 GLIS2 ZNF207 FOS SRSF1 DGKE ENSG00000262298 RNU7-134P VEZF1 GC17P057653 GC17P057625
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DGKE on UCSC Golden Path with GeneCards custom track

Genomic Location for DGKE Gene

Chromosome:
17
Start:
56,834,099 bp from pter
End:
56,869,567 bp from pter
Size:
35,469 bases
Orientation:
Plus strand

Genomic View for DGKE Gene

Genes around DGKE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGKE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGKE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKE Gene

Proteins for DGKE Gene

  • Protein details for DGKE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52429-DGKE_HUMAN
    Recommended name:
    Diacylglycerol kinase epsilon
    Protein Accession:
    P52429
    Secondary Accessions:
    • Q8TBM4
    • Q9UKQ3

    Protein attributes for DGKE Gene

    Size:
    567 amino acids
    Molecular mass:
    63927 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DGKE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DGKE Gene

Selected DME Specific Peptides for DGKE Gene

P52429:
  • CGGDGTVGW
  • PLGTGNDL
  • PMQVDGE

Post-translational modifications for DGKE Gene

  • Ubiquitination at Lys357
  • Modification sites at PhosphoSitePlus

Domains & Families for DGKE Gene

Gene Families for DGKE Gene

Graphical View of Domain Structure for InterPro Entry

P52429

UniProtKB/Swiss-Prot:

DGKE_HUMAN :
  • Belongs to the eukaryotic diacylglycerol kinase family.
Family:
  • Belongs to the eukaryotic diacylglycerol kinase family.
genes like me logo Genes that share domains with DGKE: view

Function for DGKE Gene

Molecular function for DGKE Gene

GENATLAS Biochemistry:
diacylglycerol kinase epsilon,expressed predominantly in the testis and the retina,converting diacylglycerol to phosphatidic acid,involved in the phosphorylation of arachidonate containing diacylglycerol,
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot Function:
Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition.

Enzyme Numbers (IUBMB) for DGKE Gene

Gene Ontology (GO) - Molecular Function for DGKE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003951 NAD+ kinase activity IEA --
GO:0004143 diacylglycerol kinase activity TAS,IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA,IDA 18004883
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with DGKE: view
genes like me logo Genes that share phenotypes with DGKE: view

Human Phenotype Ontology for DGKE Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DGKE Gene

MGI Knock Outs for DGKE:

Animal Model Products

  • Taconic Biosciences Mouse Models for DGKE

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DGKE
  • Applied Biological Materials Clones for DGKE

No data available for Transcription Factor Targets and HOMER Transcription for DGKE Gene

Localization for DGKE Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGKE Gene

Membrane; Multi-pass membrane protein. Membrane. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DGKE gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DGKE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA,IDA 23542698
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA,IEA 19946888
genes like me logo Genes that share ontologies with DGKE: view

Pathways & Interactions for DGKE Gene

genes like me logo Genes that share pathways with DGKE: view

Gene Ontology (GO) - Biological Process for DGKE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0008654 phospholipid biosynthetic process TAS 8626589
GO:0016310 phosphorylation IEA --
GO:0030168 platelet activation TAS --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with DGKE: view

No data available for SIGNOR curated interactions for DGKE Gene

Drugs & Compounds for DGKE Gene

(6) Drugs for DGKE Gene - From: ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Dioctanoylglycol Pharma Diacylglycerol kinase inhibitor 0
R 59-022 Pharma Diacylglycerol kinase inhibitor; increases PKC activity 0

(25) Additional Compounds for DGKE Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Hexadecanoyl-3-(11-eicosenoyl)-sn-glycerol
  • 1-Palmitoyl-3-eicosenoyl-sn-glycerol
  • DAG(16:0/0:0/20:1)
  • DAG(16:0/0:0/20:1n9)
  • DAG(16:0/0:0/20:1w9)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(2) Tocris Compounds for DGKE Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor 627-86-1
R 59-022 Diacylglycerol kinase inhibitor; increases PKC activity 93076-89-2

(1) ApexBio Compounds for DGKE Gene

Compound Action Cas Number
Dioctanoylglycol 627-86-1
genes like me logo Genes that share compounds with DGKE: view

Drug Products

Transcripts for DGKE Gene

Unigene Clusters for DGKE Gene

Diacylglycerol kinase, epsilon 64kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DGKE
  • Applied Biological Materials Clones for DGKE

Alternative Splicing Database (ASD) splice patterns (SP) for DGKE Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: -
SP2:
SP3:

Relevant External Links for DGKE Gene

GeneLoc Exon Structure for
DGKE
ECgene alternative splicing isoforms for
DGKE

Expression for DGKE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DGKE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DGKE Gene

This gene is overexpressed in Retina (45.5) and Testis (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DGKE Gene



NURSA nuclear receptor signaling pathways regulating expression of DGKE Gene:

DGKE

SOURCE GeneReport for Unigene cluster for DGKE Gene:

Hs.239514

mRNA Expression by UniProt/SwissProt for DGKE Gene:

P52429-DGKE_HUMAN
Tissue specificity: Expressed predominantly in testis. Expressed in endothelium, platelets and podocytes (at protein level).

Evidence on tissue expression from TISSUES for DGKE Gene

  • Heart(4.1)
  • Nervous system(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for DGKE Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • immune
  • integumentary
  • respiratory
  • urinary
Organs:
Thorax:
  • lung
Abdomen:
  • kidney
Pelvis:
  • urinary bladder
General:
  • blood
  • blood vessel
  • coagulation system
  • red blood cell
  • skin
genes like me logo Genes that share expression patterns with DGKE: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for DGKE Gene

Orthologs for DGKE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DGKE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DGKE 34 35
  • 99.35 (n)
dog
(Canis familiaris)
Mammalia DGKE 34 35
  • 91.43 (n)
cow
(Bos Taurus)
Mammalia DGKE 34 35
  • 90.96 (n)
mouse
(Mus musculus)
Mammalia Dgke 34 16 35
  • 87.23 (n)
oppossum
(Monodelphis domestica)
Mammalia DGKE 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DGKE 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves DGKE 34 35
  • 77.11 (n)
lizard
(Anolis carolinensis)
Reptilia DGKE 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dgke 34
  • 72.7 (n)
zebrafish
(Danio rerio)
Actinopterygii dgke 34 35
  • 68.09 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006768 34
  • 49.09 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dgkepsilon 34 35
  • 48.26 (n)
Dgkegr 36
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea dgk-2 36 34 35
  • 48.7 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons DGK1 34
  • 47.29 (n)
rice
(Oryza sativa)
Liliopsida Os12g0576900 34
  • 47.77 (n)
Species where no ortholog for DGKE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DGKE Gene

ENSEMBL:
Gene Tree for DGKE (if available)
TreeFam:
Gene Tree for DGKE (if available)

Paralogs for DGKE Gene

Paralogs for DGKE Gene

(2) SIMAP similar genes for DGKE Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DGKE: view

Variants for DGKE Gene

Sequence variations from dbSNP and Humsavar for DGKE Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs312262694 other, Hemolytic uremic syndrome atypical 7 (AHUS7) [MIM:615008] 56,834,983(+) GTGGC(C/G)CGACA nc-transcript-variant, upstream-variant-2KB, reference, missense
rs312262695 Likely pathogenic, Hemolytic uremic syndrome atypical 7 (AHUS7) [MIM:615008] 56,847,995(+) AGCTC(A/C/G)AGTAC nc-transcript-variant, reference, missense
VAR_036120 A breast cancer sample
rs147972030 Pathogenic 56,844,164(+) AAAAA(-/A)CAGAT nc-transcript-variant, reference, frameshift-variant
rs398123008 Pathogenic 56,834,922(+) GCCTC(C/T)AGCGG nc-transcript-variant, upstream-variant-2KB, reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for DGKE Gene

Variant ID Type Subtype PubMed ID
esv2658087 CNV deletion 23128226
esv32884 CNV loss 17666407
nsv1142226 CNV tandem duplication 24896259
nsv833495 CNV loss 17160897

Variation tolerance for DGKE Gene

Residual Variation Intolerance Score: 16.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DGKE Gene

Human Gene Mutation Database (HGMD)
DGKE
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DGKE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGKE Gene

Disorders for DGKE Gene

MalaCards: The human disease database

(6) MalaCards diseases for DGKE Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards