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Aliases for DGKE Gene

Aliases for DGKE Gene

  • Diacylglycerol Kinase Epsilon 2 3 5
  • Diacylglycerol Kinase, Epsilon 64kDa 2 3
  • Diglyceride Kinase Epsilon 3 4
  • DAG Kinase Epsilon 3 4
  • EC 2.7.1.107 4 63
  • DGK-Epsilon 3 4
  • DAGK5 3 4
  • Diacylglycerol Kinase, Epsilon (64kD) 2
  • AHUS7 3
  • DAGK6 3
  • NPHS7 3
  • DGK 3

External Ids for DGKE Gene

Previous GeneCards Identifiers for DGKE Gene

  • GC17P054648
  • GC17P057392
  • GC17P055253
  • GC17P055386
  • GC17P052266
  • GC17P054911
  • GC17P050271

Summaries for DGKE Gene

Entrez Gene Summary for DGKE Gene

  • Diacylglycerol kinases are thought to be involved mainly in the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. When expressed in mammalian cells, DGK-epsilon shows specificity for arachidonyl-containing diacylglycerol. DGK-epsilon is expressed predominantly in testis. [provided by RefSeq, Jul 2008]

GeneCards Summary for DGKE Gene

DGKE (Diacylglycerol Kinase Epsilon) is a Protein Coding gene. Diseases associated with DGKE include nephrotic syndrome, type 7 and immunoglobulin-mediated membranoproliferative glomerulonephritis. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include NAD+ kinase activity and diacylglycerol kinase activity. An important paralog of this gene is DGKI.

UniProtKB/Swiss-Prot for DGKE Gene

  • Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition.

Tocris Summary for DGKE Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGKE Gene

Genomics for DGKE Gene

Regulatory Elements for DGKE Gene

Promoters for DGKE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DGKE on UCSC Golden Path with GeneCards custom track

Genomic Location for DGKE Gene

Chromosome:
17
Start:
56,834,099 bp from pter
End:
56,869,567 bp from pter
Size:
35,469 bases
Orientation:
Plus strand

Genomic View for DGKE Gene

Genes around DGKE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGKE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGKE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKE Gene

Proteins for DGKE Gene

  • Protein details for DGKE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52429-DGKE_HUMAN
    Recommended name:
    Diacylglycerol kinase epsilon
    Protein Accession:
    P52429
    Secondary Accessions:
    • Q8TBM4
    • Q9UKQ3

    Protein attributes for DGKE Gene

    Size:
    567 amino acids
    Molecular mass:
    63927 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DGKE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DGKE Gene

Proteomics data for DGKE Gene at MOPED

Selected DME Specific Peptides for DGKE Gene

Post-translational modifications for DGKE Gene

  • Ubiquitination at Lys 357
  • Modification sites at PhosphoSitePlus

Other Protein References for DGKE Gene

Antibody Products

Domains & Families for DGKE Gene

Gene Families for DGKE Gene

Graphical View of Domain Structure for InterPro Entry

P52429

UniProtKB/Swiss-Prot:

DGKE_HUMAN :
  • Contains 1 DAGKc domain.
  • Belongs to the eukaryotic diacylglycerol kinase family.
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
Domain:
  • Contains 1 DAGKc domain.
Family:
  • Belongs to the eukaryotic diacylglycerol kinase family.
Similarity:
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
genes like me logo Genes that share domains with DGKE: view

Function for DGKE Gene

Molecular function for DGKE Gene

GENATLAS Biochemistry:
diacylglycerol kinase epsilon,expressed predominantly in the testis and the retina,converting diacylglycerol to phosphatidic acid,involved in the phosphorylation of arachidonate containing diacylglycerol,
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot Function:
Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition.

Enzyme Numbers (IUBMB) for DGKE Gene

genes like me logo Genes that share phenotypes with DGKE: view

Human Phenotype Ontology for DGKE Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DGKE Gene

MGI Knock Outs for DGKE:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for DGKE Gene

Localization for DGKE Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGKE Gene

Membrane; Multi-pass membrane protein. Membrane. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DGKE Gene COMPARTMENTS Subcellular localization image for DGKE gene
Compartment Confidence
cytosol 4
plasma membrane 4
nucleus 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for DGKE Gene

Pathways & Interactions for DGKE Gene

genes like me logo Genes that share pathways with DGKE: view

Gene Ontology (GO) - Biological Process for DGKE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008654 phospholipid biosynthetic process TAS 8626589
genes like me logo Genes that share ontologies with DGKE: view

No data available for SIGNOR curated interactions for DGKE Gene

Drugs & Compounds for DGKE Gene

(2) Drugs for DGKE Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(29) Additional Compounds for DGKE Gene - From: HMDB, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(2) Tocris Compounds for DGKE Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor 627-86-1
R 59-022 Diacylglycerol kinase inhibitor; increases PKC activity 93076-89-2
genes like me logo Genes that share compounds with DGKE: view

Transcripts for DGKE Gene

Unigene Clusters for DGKE Gene

Diacylglycerol kinase, epsilon 64kDa:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DGKE Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: -
SP2:
SP3:

Relevant External Links for DGKE Gene

GeneLoc Exon Structure for
DGKE
ECgene alternative splicing isoforms for
DGKE

Expression for DGKE Gene

mRNA expression in normal human tissues for DGKE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DGKE Gene

This gene is overexpressed in Retina (45.5) and Testis (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DGKE Gene



SOURCE GeneReport for Unigene cluster for DGKE Gene Hs.239514

mRNA Expression by UniProt/SwissProt for DGKE Gene

P52429-DGKE_HUMAN
Tissue specificity: Expressed predominantly in testis. Expressed in endothelium, platelets and podocytes (at protein level).
genes like me logo Genes that share expression patterns with DGKE: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for DGKE Gene

Orthologs for DGKE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DGKE Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DGKE 35
  • 90.96 (n)
  • 93.79 (a)
DGKE 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DGKE 35
  • 91.43 (n)
  • 95.92 (a)
DGKE 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dgke 35
  • 87.23 (n)
  • 91.31 (a)
Dgke 16
Dgke 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DGKE 35
  • 99.35 (n)
  • 99.65 (a)
DGKE 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DGKE 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DGKE 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves DGKE 35
  • 77.11 (n)
  • 79.42 (a)
DGKE 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DGKE 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dgke 35
  • 72.7 (n)
  • 78.68 (a)
zebrafish
(Danio rerio)
Actinopterygii dgke 35
  • 68.09 (n)
  • 72.07 (a)
dgke 36
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dgkegr 37
  • 37 (a)
Dgkepsilon 35
  • 48.26 (n)
  • 39.38 (a)
Dgkepsilon 36
  • 37 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006768 35
  • 49.09 (n)
  • 42.05 (a)
worm
(Caenorhabditis elegans)
Secernentea dgk-2 37
  • 35 (a)
dgk-2 35
  • 48.7 (n)
  • 40.04 (a)
dgk-2 36
  • 38 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons DGK1 35
  • 47.29 (n)
  • 39.59 (a)
rice
(Oryza sativa)
Liliopsida Os12g0576900 35
  • 47.77 (n)
  • 38.46 (a)
Species with no ortholog for DGKE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DGKE Gene

ENSEMBL:
Gene Tree for DGKE (if available)
TreeFam:
Gene Tree for DGKE (if available)

Paralogs for DGKE Gene

Paralogs for DGKE Gene

(2) SIMAP similar genes for DGKE Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DGKE: view

Variants for DGKE Gene

Sequence variations from dbSNP and Humsavar for DGKE Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_036120 A breast cancer sample
VAR_069804 Hemolytic uremic syndrome atypical 7 (AHUS7)
rs312262695 Hemolytic uremic syndrome atypical 7 (AHUS7) 56,847,995(+) AGCTC(A/C/G)AGTAC nc-transcript-variant, reference, missense
rs2230873 -- 56,862,167(+) GTCGT(C/T)GGAGT downstream-variant-500B, reference, synonymous-codon
rs1992553 -- 56,868,309(-) GTTCA(A/G)ATCTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DGKE Gene

Variant ID Type Subtype PubMed ID
nsv833495 CNV Loss 17160897
esv32884 CNV Loss 17666407
nsv908632 CNV Loss 21882294
esv2658087 CNV Deletion 23128226

Variation tolerance for DGKE Gene

Residual Variation Intolerance Score: 16.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DGKE Gene

HapMap Linkage Disequilibrium report
DGKE
Human Gene Mutation Database (HGMD)
DGKE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGKE Gene

Disorders for DGKE Gene

MalaCards: The human disease database

(5) MalaCards diseases for DGKE Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
nephrotic syndrome, type 7
  • hemolytic uremic syndrome, atypical 7
immunoglobulin-mediated membranoproliferative glomerulonephritis
  • ig-mediated mpgn
atypical hemolytic-uremic syndrome with dgke deficiency
  • atypical hus with dgke deficiency
hemolytic-uremic syndrome
  • haemolytic-uraemic syndrome
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards
Search DGKE in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DGKE_HUMAN
  • Hemolytic uremic syndrome atypical 7 (AHUS7) [MIM:615008]: An atypical form of hemolytic uremic syndrome characterized by acute onset in the first year of life of microangiopathic hemolytic anemia, thrombocytopenia, and renal failure. After the acute episode, most patients develop chronic renal insufficiency. Unlike other genetic forms of aHUS, AHUS7 is not related to abnormal activation of the complement system. {ECO:0000269 PubMed:23542698}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Nephrotic syndrome 7 (NPHS7) [MIM:615008]: A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. NPHS7 is an autosomal recessive form characterized by onset of proteinuria usually in the first decade of life. The disorder is progressive, and some patients develop end-stage renal disease within several years. Renal biopsy typically shows membranoproliferative glomerulonephritis. {ECO:0000269 PubMed:23274426}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for DGKE

Genetic Association Database (GAD)
DGKE
Human Genome Epidemiology (HuGE) Navigator
DGKE
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DGKE
genes like me logo Genes that share disorders with DGKE: view

No data available for Genatlas for DGKE Gene

Publications for DGKE Gene

  1. Molecular cloning of a novel human diacylglycerol kinase highly selective for arachidonate-containing substrates. (PMID: 8626589) Tang W. … Prescott S.M. (J. Biol. Chem. 1996) 2 3 4 23 67
  2. Diacylglycerol kinase epsilon is selective for both acyl chains of phosphatidic acid or diacylglycerol. (PMID: 19744926) Lung M. … Epand R.M. (J. Biol. Chem. 2009) 3 23
  3. Role of the hydrophobic segment of diacylglycerol kinase epsilon. (PMID: 17455907) Dicu A.O. … Epand R.M. (Biochemistry 2007) 3 23
  4. Cytogenetic assignment and physical mapping of the human DGKE gene to chromosome 17q22. (PMID: 10051413) Hart T.C. … Van Dyke T.E. (Genomics 1999) 2 3
  5. Characterization of the human diacylglycerol kinase epsilon gene and its assessment as a candidate for inherited retinitis pigmentosa. (PMID: 10571048) Tang W. … Prescott S.M. (Gene 1999) 3 23

Products for DGKE Gene

Sources for DGKE Gene

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