Aliases for DGKE Gene
External Ids for DGKE Gene
Previous GeneCards Identifiers for DGKE Gene
Diacylglycerol kinases are thought to be involved mainly in the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. When expressed in mammalian cells, DGK-epsilon shows specificity for arachidonyl-containing diacylglycerol. DGK-epsilon is expressed predominantly in testis. [provided by RefSeq, Jul 2008]
GeneCards Summary for DGKE Gene
DGKE (Diacylglycerol Kinase, Epsilon 64kDa) is a Protein Coding gene. Diseases associated with DGKE include immunoglobulin-mediated membranoproliferative glomerulonephritis and atypical hemolytic-uremic syndrome with dgke deficiency. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include NAD+ kinase activity and diacylglycerol kinase activity. An important paralog of this gene is DGKI.
UniProtKB/Swiss-Prot for DGKE Gene
Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition
Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.