Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DGKE Gene

Aliases for DGKE Gene

  • Diacylglycerol Kinase Epsilon 2 3 5
  • Diacylglycerol Kinase, Epsilon 64kDa 2 3
  • Diglyceride Kinase Epsilon 3 4
  • DAG Kinase Epsilon 3 4
  • EC 2.7.1.107 4 61
  • DGK-Epsilon 3 4
  • DAGK5 3 4
  • Diacylglycerol Kinase, Epsilon (64kD) 2
  • AHUS7 3
  • DAGK6 3
  • NPHS7 3
  • DGK 3

External Ids for DGKE Gene

Previous GeneCards Identifiers for DGKE Gene

  • GC17P054648
  • GC17P057392
  • GC17P055253
  • GC17P055386
  • GC17P052266
  • GC17P054911
  • GC17P050271

Summaries for DGKE Gene

Entrez Gene Summary for DGKE Gene

  • Diacylglycerol kinases are thought to be involved mainly in the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. When expressed in mammalian cells, DGK-epsilon shows specificity for arachidonyl-containing diacylglycerol. DGK-epsilon is expressed predominantly in testis. [provided by RefSeq, Jul 2008]

GeneCards Summary for DGKE Gene

DGKE (Diacylglycerol Kinase Epsilon) is a Protein Coding gene. Diseases associated with DGKE include Nephrotic Syndrome, Type 7 and Hemolytic-Uremic Syndrome. Among its related pathways are Signaling by GPCR and Effects of PIP2 hydrolysis. GO annotations related to this gene include NAD+ kinase activity and diacylglycerol kinase activity. An important paralog of this gene is DGKQ.

UniProtKB/Swiss-Prot for DGKE Gene

  • Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition.

Tocris Summary for DGKE Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGKE Gene

Genomics for DGKE Gene

Regulatory Elements for DGKE Gene

Enhancers for DGKE Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F057458 1.8 FANTOM5 Ensembl ENCODE 20.5 +628.6 628556 8.5 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF207 FOS SRSF1 COIL ENSG00000262298 DGKE VEZF1 ENSG00000279281 LOC101927557
GH17F057541 1.5 VISTA Ensembl ENCODE 20.7 +708.1 708117 2.0 PKNOX1 ATF1 SIN3A FEZF1 ZNF2 ZNF263 SP3 JUNB REST TSHZ1 DGKE SRSF1 ENSG00000280028 LOC101927539
GH17F056911 1.6 FANTOM5 ENCODE 12 +80.9 80893 6.8 HDGF CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 TRIM25 ENSG00000262298 SCPEP1 DGKE COIL ENSG00000274213
GH17F057602 1.6 FANTOM5 Ensembl ENCODE 11.8 +772.3 772255 7.5 ATF1 MLX ARID4B FEZF1 DMAP1 ZNF48 ZNF143 MXD4 MIER2 REST CCDC182 LOC101927557 ENSG00000264914 OR4D1 LOC100419768 SETP3 DGKE SRSF1 MSI2 LOC101927539
GH17F056697 1.2 Ensembl ENCODE 14.5 -135.1 -135086 3.2 TBP PKNOX1 SIN3A ZBTB40 GTF3C2 ZNF766 ELK1 POLR3A ZNF366 SCRT2 DGKE ENSG00000262298 NOG GC17M056726 GC17P056602
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DGKE on UCSC Golden Path with GeneCards custom track

Promoters for DGKE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001536844 -99 2801 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A YBX1 DMAP1 ZNF2 ZNF207
ENSR00001808306 1601 201 ZFP3

Genomic Location for DGKE Gene

Chromosome:
17
Start:
56,834,099 bp from pter
End:
56,869,567 bp from pter
Size:
35,469 bases
Orientation:
Plus strand

Genomic View for DGKE Gene

Genes around DGKE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGKE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGKE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKE Gene

Proteins for DGKE Gene

  • Protein details for DGKE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52429-DGKE_HUMAN
    Recommended name:
    Diacylglycerol kinase epsilon
    Protein Accession:
    P52429
    Secondary Accessions:
    • Q8TBM4
    • Q9UKQ3

    Protein attributes for DGKE Gene

    Size:
    567 amino acids
    Molecular mass:
    63927 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DGKE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DGKE Gene

Selected DME Specific Peptides for DGKE Gene

P52429:
  • CGGDGTVGW
  • PLGTGNDL
  • PMQVDGE

Post-translational modifications for DGKE Gene

  • Ubiquitination at Lys 357
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for DGKE

Domains & Families for DGKE Gene

Gene Families for DGKE Gene

Graphical View of Domain Structure for InterPro Entry

P52429

UniProtKB/Swiss-Prot:

DGKE_HUMAN :
  • Contains 1 DAGKc domain.
  • Belongs to the eukaryotic diacylglycerol kinase family.
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
Domain:
  • Contains 1 DAGKc domain.
Family:
  • Belongs to the eukaryotic diacylglycerol kinase family.
Similarity:
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
genes like me logo Genes that share domains with DGKE: view

Function for DGKE Gene

Molecular function for DGKE Gene

GENATLAS Biochemistry:
diacylglycerol kinase epsilon,expressed predominantly in the testis and the retina,converting diacylglycerol to phosphatidic acid,involved in the phosphorylation of arachidonate containing diacylglycerol,
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot Function:
Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition.

Enzyme Numbers (IUBMB) for DGKE Gene

Gene Ontology (GO) - Molecular Function for DGKE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004143 diacylglycerol kinase activity IEA,TAS --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA,IDA 18004883
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DGKE: view
genes like me logo Genes that share phenotypes with DGKE: view

Human Phenotype Ontology for DGKE Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DGKE Gene

MGI Knock Outs for DGKE:

Animal Model Products

  • Taconic Biosciences Mouse Models for DGKE

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DGKE

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for DGKE Gene

Localization for DGKE Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGKE Gene

Membrane; Multi-pass membrane protein. Membrane. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DGKE gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DGKE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA,IDA 23542698
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DGKE: view

Pathways & Interactions for DGKE Gene

genes like me logo Genes that share pathways with DGKE: view

Gene Ontology (GO) - Biological Process for DGKE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0008654 phospholipid biosynthetic process TAS 8626589
GO:0016310 phosphorylation IEA --
GO:0030168 platelet activation TAS --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with DGKE: view

No data available for SIGNOR curated interactions for DGKE Gene

Drugs & Compounds for DGKE Gene

(6) Drugs for DGKE Gene - From: ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Dioctanoylglycol Pharma Diacylglycerol kinase inhibitor 0
R 59-022 Pharma Diacylglycerol kinase inhibitor; increases PKC activity 0

(25) Additional Compounds for DGKE Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(2) Tocris Compounds for DGKE Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor 627-86-1
R 59-022 Diacylglycerol kinase inhibitor; increases PKC activity 93076-89-2

(1) ApexBio Compounds for DGKE Gene

Compound Action Cas Number
Dioctanoylglycol 627-86-1
genes like me logo Genes that share compounds with DGKE: view

Transcripts for DGKE Gene

Unigene Clusters for DGKE Gene

Diacylglycerol kinase, epsilon 64kDa:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DGKE

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DGKE Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: -
SP2:
SP3:

Relevant External Links for DGKE Gene

GeneLoc Exon Structure for
DGKE
ECgene alternative splicing isoforms for
DGKE

Expression for DGKE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DGKE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DGKE Gene

This gene is overexpressed in Retina (45.5) and Testis (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DGKE Gene



NURSA nuclear receptor signaling pathways regulating expression of DGKE Gene:

DGKE

SOURCE GeneReport for Unigene cluster for DGKE Gene:

Hs.239514

mRNA Expression by UniProt/SwissProt for DGKE Gene:

P52429-DGKE_HUMAN
Tissue specificity: Expressed predominantly in testis. Expressed in endothelium, platelets and podocytes (at protein level).
genes like me logo Genes that share expression patterns with DGKE: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for DGKE Gene

Orthologs for DGKE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DGKE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DGKE 34 35
  • 99.35 (n)
dog
(Canis familiaris)
Mammalia DGKE 34 35
  • 91.43 (n)
cow
(Bos Taurus)
Mammalia DGKE 34 35
  • 90.96 (n)
mouse
(Mus musculus)
Mammalia Dgke 34 16 35
  • 87.23 (n)
oppossum
(Monodelphis domestica)
Mammalia DGKE 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DGKE 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves DGKE 34 35
  • 77.11 (n)
lizard
(Anolis carolinensis)
Reptilia DGKE 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dgke 34
  • 72.7 (n)
zebrafish
(Danio rerio)
Actinopterygii dgke 34 35
  • 68.09 (n)