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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DGKE Gene

protein-coding   GIFtS: 63
GCID: GC17P054911

diacylglycerol kinase, epsilon 64kDa

(Previous names: diacylglycerol kinase, epsilon (64kD) )
 Explore 9 diseases affiliated with
DGKE via our new
 Human Malady Compendium 
Biological research products
for DGKE
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Diacylglycerol Kinase, Epsilon 64kDa1 2     DAG Kinase Epsilon2 3
DAGK61 2     EC 2.7.1.1073 8
DGK1 2     Diacylglycerol Kinase, Epsilon (64kD)1
Diglyceride Kinase Epsilon2 3     NPHS72
DAGK52 3     Diacylglycerol Kinase Epsilon2
DGK-Epsilon1     

External Ids:    HGNC: 28521   Entrez Gene: 85262   Ensembl: ENSG000001539337   OMIM: 6014405   UniProtKB: P524293   

Export aliases for DGKE gene to outside databases

Previous GC identifers: GC17P054648 GC17P057392 GC17P055253 GC17P055386 GC17P052266 GC17P050271


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DGKE:
Diacylglycerol kinases are thought to be involved mainly in the regeneration of phosphatidylinositol (PI) from
diacylglycerol in the PI-cycle during cell signal transduction. When expressed in mammalian cells, DGK-epsilon shows
specificity for arachidonyl-containing diacylglycerol. DGK-epsilon is expressed predominantly in testis. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DGKE_HUMAN, P52429
Function: Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals
transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid
composition

summary for DGKE:
Diacylglycerol kinases (DGKs) are a group of ten enzymes (DGKalpha, DGKbeta, DGKgamma, DGKdelta, DGKepsilon,
DGKzeta, DGKeta, DGKtheta, DGKiota and DGKkappa) that metabolize 1,2,diacylglycerol (DAG) to produce
phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain, two cysteine-rich
Zn2+-finger motifs that bind DAG and an ATP-binding site, whilst the regulatory domain varies. DGKs are
widely distributed throughout mammalian tissues and different isozymes have different subcellular
localizations; some are cytosolic (for example DGKalpha), some are membrane-bound (for example DGKgamma is
associated with the Golgi membrane) and some are nuclear (for example DGKzeta. DGKs have diverse biological
roles as they participate in signal transduction by modulating levels of DAG in a variety of cellular
responses to extracellular stimuli.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DGKE gene promoter:
         RFX1   FOXO3   MIF-1   FOXO3b   HEN1   AREB6   MEF-2A   NRF-2   FOXO3a   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDGKE promoter sequence
   Search SABiosciences Chromatin IP Primers for DGKE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DGKE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q22

DGKE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DGKE gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P054911:  view genomic region     (about GC identifiers)

Start:
54,911,460 bp from pter      End:
54,946,036 bp from pter
Size:
34,577 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DGKE_HUMAN, P52429 (See protein sequence)
Recommended Name: Diacylglycerol kinase epsilon  
Size: 567 amino acids; 63927 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q9UKQ3

Explore the universe of human proteins at neXtProt for DGKE: NX_P52429

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P52429

  • 3 DME Specific Peptides for DGKE (P52429)
     PMQVDGE  PLGTGNDL  CGGDGTVGW 

    DGKE Protein expression data from MOPED and PaxDb:    About this image 
    DGKE Protein Expression
    REFSEQ proteins: NP_003638.1  
    ENSEMBL proteins: 
     ENSP00000284061   ENSP00000459295   ENSP00000458493   ENSP00000459958  
    Reactome Protein details: P52429
    Human Recombinant Protein Products for DGKE: 
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    Novus Biologicals DGKE Lysate
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    DGKE for ontologies           About GeneDecksing



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    Browse ELISAs and CLIAs at Uscn


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    DGKE for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001206 Diacylglycerol_kinase_cat_dom
     IPR002219 Prot_Kinase_C-like_PE/DAG-bd
     IPR000756 Diacylglycerol_kin_accessory

    Graphical View of Domain Structure for InterPro Entry P52429

    ProtoNet protein and cluster: P52429

    1 Blocks protein family: IPB000756 Diacylglycerol kinase accessory domain (presumed)

    UniProtKB/Swiss-Prot: DGKE_HUMAN, P52429
    Similarity: Belongs to the eukaryotic diacylglycerol kinase family
    Similarity: Contains 1 DAGKc domain
    Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DGKE_HUMAN, P52429
    Function: Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals
    transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid
    composition
    Catalytic activity: ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate

         Genatlas biochemistry entry for DGKE:
    diacylglycerol kinase epsilon,expressed predominantly in the testis and the retina,converting diacylglycerol to
    phosphatidic acid,involved in the phosphorylation of arachidonate containing diacylglycerol,

         Enzyme Number (IUBMB): EC 2.7.1.1071 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004143diacylglycerol kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0046872metal ion binding IEA--
         
    DGKE for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DGKE:
     Decreased focal adhesion (FA)  

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dgke):
     behavior/neurological  nervous system 

    DGKE for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Dgketm1Ngb for DGKE
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DGKE 

    miRNA
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    hsa-miR-3678-3p hsa-miR-520e hsa-miR-298 hsa-miR-3116 hsa-miR-489 hsa-miR-3613-3p hsa-miR-130b hsa-miR-520b
    SwitchGear 3'UTR luciferase reporter plasmidDGKE 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DGKE (see all 4)
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGKE


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by GPCR
    Signaling by GPCR1.00
    Signal Transduction0.56
    GPCR downstream signaling0.89
    2Platelet activation, signaling and aggregation
    Platelet activation, signaling and aggregation1.00
    Hemostasis0.43
    3G alpha (q) signalling events
    G alpha (q) signalling events1.00
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    4Effects of PIP2 hydrolysis
    Effects of PIP2 hydrolysis1.00
    5Glycerolipid metabolism
    Glycerolipid metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/8        Reactome Pathways for DGKE (see all 8)
        GPCR downstream signaling
    Hemostasis
    Effects of PIP2 hydrolysis
    Signal Transduction
    Gastrin-CREB signalling pathway via PKC and MAPK


    4         Kegg Pathways  (Kegg details for DGKE):
        Glycerolipid metabolism
    Glycerophospholipid metabolism
    Metabolic pathways
    Phosphatidylinositol signaling system


    DGKE for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DGKE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/48 Interacting proteins for DGKE (P524293 ENSP000002840614) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PAICSP222343, ENSP000003825954I2D: score=2 STRING: ENSP00000382595
    PDHA1P085593, ENSP000003943824I2D: score=2 STRING: ENSP00000394382
    SETQ011053, ENSP000003617774I2D: score=2 STRING: ENSP00000361777
    NUF2Q9BZD43, ENSP000002714524I2D: score=2 STRING: ENSP00000271452
    NUDCQ9Y2663, ENSP000003196644I2D: score=2 STRING: ENSP00000319664
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway IEA--
    GO:0007596blood coagulation TAS--
    GO:0008654phospholipid biosynthetic process TAS8626589
    GO:0030168platelet activation TAS--
    GO:0035556intracellular signal transduction IEA--

    DGKE for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DGKE for compounds           About GeneDecksing

    EMD Millipore small molecules for DGKE:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for DGKE available from Tocris Bioscience    About this table
    CompoundAction CAS #
    R 59-022Diacylglycerol kinase inhibitor; increases PKC activity[93076-89-2]
    DioctanoylglycolDiacylglycerol kinase inhibitor[627-86-1]

    10/862 HMDB Compounds for DGKE (see all 862)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    6 Novoseek chemical compound relationships for DGKE gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipid 40.4 3 10913605 (1), 11136721 (1), 9447972 (1)
    ceramide 34.5 5 12385893 (3), 16571915 (1)
    phosphoinositide 29.1 1 17360902 (1)
    fatty acid 16 1 10571048 (1)
    zinc 4.37 2 8626589 (1), 9438377 (1)
    glucose 0 1 15315262 (1)

    Search CenterWatch for drugs/clinical trials and news about DGKE 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DGKE gene: 
    NM_003647.2  

    Unigene Cluster for DGKE:

    Diacylglycerol kinase, epsilon 64kDa
    Hs.239514  [show with all ESTs]
    Unigene Representative Sequence: NM_003647
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000284061(uc002iur.3) ENST00000572810 ENST00000576869 ENST00000572944(uc002ius.1)
    ENST00000571084 ENST00000570738

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    hsa-miR-3678-3p hsa-miR-520e hsa-miR-298 hsa-miR-3116 hsa-miR-489 hsa-miR-3613-3p hsa-miR-130b hsa-miR-520b
    SwitchGear 3'UTR luciferase reporter plasmidDGKE 3' UTR sequence
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    Additional cDNA sequence: 

    AB209365.1 AK057591.1 AK129803.1 AK293039.1 AK310668.1 BC022297.1 BC130629.1 BC130631.1 
    U49379.1 

    5 DOTS entries:

    DT.432573  DT.310317  DT.120927290  DT.92036162  DT.120956139 

    24/28 AceView cDNA sequences (see all 28):

    CA391764 CR622919 BX329274 BX390069 AA287006 BM983232 AI688534 BC022297 
    AL706818 BX089763 BF732316 BG770880 NM_003647 U49379 BX506599 AL555194 
    AA278962 AL555193 AA284392 AA807749 BQ307355 AA252464 BF107055 AA764732 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DGKE    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                    -                                                                     
    SP2:                                                                                          
    SP3:                                                                                          


    ECgene alternative splicing isoforms for DGKE

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DGKE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CATTTTTATT
    DGKE Expression
    About this image
    See DGKE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DGKE

    SOURCE GeneReport for Unigene cluster: Hs.239514

    UniProtKB/Swiss-Prot: DGKE_HUMAN, P52429
    Tissue specificity: Expressed predominantly in testis

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGKE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DGKE gene from 7/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves DGKE1 diacylglycerol kinase, epsilon 64kDa 77.21(n)
    79.71(a)
      770911  XM_001234225.2  XP_001234226.2 
    lizard
    (Anolis carolinensis)
    Reptilia DGKE6
    --
    79(a)
    1 ↔ 1
    GL343198.1(598722-622051)
    zebrafish
    (Danio rerio)
    Actinopterygii dgke1 diacylglycerol kinase epsilon 68.09(n)
    72.07(a)
      100150463  NM_001172228.1  NP_001165699.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dgk&egr;3
    Dgkepsilon1
    phosphorylation diacylglycerol kinase3
    Diacyl glycerol kinase epsilon1
    37(a)3
    48.32(n)1
    39.71(a)1
      49D23
    364081  NM_165949.11  NP_725228.11 
    worm
    (Caenorhabditis elegans)
    Secernentea dgk-21 , 3 diaglycerol kinase3
    Protein DGK-21
    35(a)3
    48.64(n)1
    40.12(a)1
      X(4530446-4539381)3
    1807201  NM_001029508.21  NP_001024679.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons DGK21 diacylglycerol kinase 2 47.48(n)
    37.86(a)
      836497  NM_125772.4  NP_201182.1 
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 8)
    diacylglycerol kinase 1, putative, expressed
    (see all 8)
    25(a)
    25(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    12(6728516-6733263)
    12(23790291-23795978)


    ENSEMBL Gene Tree for DGKE (if available)
    TreeFam Gene Tree for DGKE (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DGKE gene
    DGKH2  DGKQ2  DGKB2  DGKI2  DGKZ2  DGKA2  DGKG2  DGKD2  
    2 SIMAP similar genes for DGKE using alignment to 5 protein entries:     DGKE_HUMAN (see all proteins):
    DGKQ    DGKA

    DGKE for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/621 NCBI SNPs in DGKE are shown (see all 621    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1882694031,2
    --54909471(+) CCCAGC/GTAATT 2 -- int1 us2k10--------
    rs1479785651,2
    --54909587(+) CAGGCA/GTGAGC 2 -- us2k1 int10--------
    rs1131337501,2
    C--54909652(+) GATGAC/TCCCAG 2 -- us2k1 int12Minor allele frequency- T:0.02NA 122
    rs1924848611,2
    --54909810(+) TCTCTA/GGGATG 2 -- us2k1 int10--------
    rs1434650051,2
    --54909941(+) CTCCCA/GTAACA 2 -- us2k1 int10--------
    rs1472059761,2
    --54909946(+) ATAACA/GGCCAT 2 -- int1 us2k10--------
    rs733250501,2
    C--54910072(+) ACACCT/CAGTCA 2 -- int1 us2k12Minor allele frequency- C:0.10WA 120
    rs798012841,2
    --54910130(+) TACAAC/TAGTAT 2 -- us2k1 int10--------
    rs1848478081,2
    --54910270(+) ATATAC/TATCTA 2 -- ut51 us2k10--------
    rs780330811,2
    C--54910280(+) ATATGT/AGTATT 2 -- us2k1 ut512Minor allele frequency- A:0.07NA 122

    HapMap Linkage Disequilibrium report for DGKE (54911460 - 54946036 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for DGKE
         1 CNV: 7166

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DGKE for disorders           About GeneDecksing

    OMIM gene information: 601440    OMIM disorders: --

    9 diseases for DGKE:    About MalaCards
    retinal degeneration    retinitis pigmentosa    insulin resistance    retinitis
    hyperglycemia    hypoxia    malaria    leukemia
    neuronitis

    1 Novoseek disease relationship for DGKE gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinal degeneration 44 3 10798401 (1), 9183747 (1)

    Human Genome Epidemiology (HuGE) Navigator: DGKE (2 documents)

    Export disorders for DGKE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DGKE gene, integrated from 9 sources (see all 51):
    (articles sorted by number of sources associating them with DGKE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel human diacylglycerol kinase highly selective for arachidonate-containing substrates. (PubMed id 8626589)1, 2, 3, 9 Tang W.... Prescott S.M. (1996)
    2. Characterization of the human diacylglycerol kinase epsilon gene and its assessment as a candidate for inherited retinitis pigmentosa. (PubMed id 10571048)1, 2, 9 Tang W.... Prescott S.M. (1999)
    3. Cytogenetic assignment and physical mapping of the human DGKE gene to chromosome 17q22. (PubMed id 10051413)1, 3 Hart T.C....Van Dyke T.E. (1999)
    4. Role of the hydrophobic segment of diacylglycerol kinase epsilon. (PubMed id 17455907)1, 9 Dicu A.O....Epand R.M. (2007)
    5. Diacylglycerol kinase epsilon is selective for both a cyl chains of phosphatidic acid or diacylglycerol. (PubMed id 19744926)1, 9 Lung M....Epand R.M. (2009)
    6. Catalytic activity and acyl-chain selectivity of diacy lglycerol kinase E are modulated by residues in and near the lipoxygenase-like m otif. (PubMed id 22266092)1 D'Souza K. and Epand R.M. (2012)
    7. Inhibition of lipid signaling enzyme diacylglycerol ki nase epsilon attenuates mutant huntingtin toxicity. (PubMed id 22511757)1 Zhang N....Ellerby L.M. (2012)
    8. Reversal of redox-dependent inhibition of diacylglyce rol kinase by antioxidants in mesangial cells exposed to high glucose. (PubMed id 21725595)1 Atsumi H....Koya D. (2011)
    9. Endocannabinoids and diacylglycerol kinase activity. (PubMed id 21194521)1 Gantayet A....Epand R.M. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8526 HGNC: 2852 AceView: DGKE Ensembl:ENSG00000153933 euGenes: HUgn8526
    ECgene: DGKE Kegg: 8526 H-InvDB: DGKE

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DGKE Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DGKE gene:
    Search GeneIP for patents involving DGKE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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