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Aliases for DGKE Gene

Aliases for DGKE Gene

  • Diacylglycerol Kinase, Epsilon 64kDa 2 3
  • Diglyceride Kinase Epsilon 3 4
  • DAG Kinase Epsilon 3 4
  • EC 2.7.1.107 4 63
  • DGK-Epsilon 3 4
  • DAGK5 3 4
  • NPHS7 3 6
  • Diacylglycerol Kinase, Epsilon (64kD) 2
  • Diacylglycerol Kinase Epsilon 3
  • DAGK6 3
  • DGK 3

External Ids for DGKE Gene

Previous GeneCards Identifiers for DGKE Gene

  • GC17P054648
  • GC17P057392
  • GC17P055253
  • GC17P055386
  • GC17P052266
  • GC17P054911
  • GC17P050271

Summaries for DGKE Gene

Entrez Gene Summary for DGKE Gene

  • Diacylglycerol kinases are thought to be involved mainly in the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. When expressed in mammalian cells, DGK-epsilon shows specificity for arachidonyl-containing diacylglycerol. DGK-epsilon is expressed predominantly in testis. [provided by RefSeq, Jul 2008]

GeneCards Summary for DGKE Gene

DGKE (Diacylglycerol Kinase, Epsilon 64kDa) is a Protein Coding gene. Diseases associated with DGKE include nephrotic syndrome, type 7 and immunoglobulin-mediated membranoproliferative glomerulonephritis. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include NAD+ kinase activity and diacylglycerol kinase activity. An important paralog of this gene is DGKI.

UniProtKB/Swiss-Prot for DGKE Gene

  • Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition

Tocris Summary for DGKE Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes (DGKalpha, DGKbeta, DGKgamma, DGKdelta, DGKepsilon, DGKzeta, DGKeta, DGKtheta, DGKiota and DGKkappa) that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain, two cysteine-rich Zn2+-finger motifs that bind DAG and an ATP-binding site, whilst the regulatory domain varies. DGKs are widely distributed throughout mammalian tissues and different isozymes have different subcellular localizations; some are cytosolic (for example DGKalpha), some are membrane-bound (for example DGKgamma is associated with the Golgi membrane) and some are nuclear (for example DGKzeta. DGKs have diverse biological roles as they participate in signal transduction by modulating levels of DAG in a variety of cellular responses to extracellular stimuli.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGKE Gene

Genomics for DGKE Gene

Regulatory Elements for DGKE Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DGKE Gene

Start:
56,834,099 bp from pter
End:
56,869,567 bp from pter
Size:
35,469 bases
Orientation:
Plus strand

Genomic View for DGKE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DGKE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKE Gene

Proteins for DGKE Gene

  • Protein details for DGKE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52429-DGKE_HUMAN
    Recommended name:
    Diacylglycerol kinase epsilon
    Protein Accession:
    P52429
    Secondary Accessions:
    • Q8TBM4
    • Q9UKQ3

    Protein attributes for DGKE Gene

    Size:
    567 amino acids
    Molecular mass:
    63927 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DGKE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DGKE Gene

Proteomics data for DGKE Gene at MOPED

Selected DME Specific Peptides for DGKE Gene

Post-translational modifications for DGKE Gene

  • Ubiquitination at Lys357
  • Modification sites at PhosphoSitePlus

Other Protein References for DGKE Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for DGKE Gene

Graphical View of Domain Structure for InterPro Entry

P52429

UniProtKB/Swiss-Prot:

DGKE_HUMAN :
  • P52429
Domain:
  • Contains 1 DAGKc domain.
Family:
  • Belongs to the eukaryotic diacylglycerol kinase family.
Similarity:
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
genes like me logo Genes that share domains with DGKE: view

No data available for Gene Families for DGKE Gene

Function for DGKE Gene

Molecular function for DGKE Gene

GENATLAS Biochemistry: diacylglycerol kinase epsilon,expressed predominantly in the testis and the retina,converting diacylglycerol to phosphatidic acid,involved in the phosphorylation of arachidonate containing diacylglycerol,
UniProtKB/Swiss-Prot CatalyticActivity: ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate
UniProtKB/Swiss-Prot Function: Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition

Enzyme Numbers (IUBMB) for DGKE Gene

Gene Ontology (GO) - Molecular Function for DGKE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003951 NAD+ kinase activity IEA --
GO:0004143 diacylglycerol kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DGKE: view

Phenotypes for DGKE Gene

MGI mutant phenotypes for DGKE:
inferred from 1 alleles
GenomeRNAi human phenotypes for DGKE:
genes like me logo Genes that share phenotypes with DGKE: view

Animal Models for DGKE Gene

MGI Knock Outs for DGKE:

Animal Model Products

CRISPR Products

miRNA for DGKE Gene

miRTarBase miRNAs that target DGKE

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DGKE

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for DGKE Gene

Localization for DGKE Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGKE Gene

Membrane; Multi-pass membrane protein. Membrane. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DGKE Gene COMPARTMENTS Subcellular localization image for DGKE gene
Compartment Confidence
plasma membrane 4
cytosol 3
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DGKE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 23542698
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DGKE: view

Pathways for DGKE Gene

genes like me logo Genes that share pathways with DGKE: view

Gene Ontology (GO) - Biological Process for DGKE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0007596 blood coagulation TAS --
GO:0008654 phospholipid biosynthetic process TAS 8626589
GO:0016310 phosphorylation IEA --
GO:0030168 platelet activation TAS --
genes like me logo Genes that share ontologies with DGKE: view

Compounds for DGKE Gene

(1) Tocris Compounds for DGKE Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor [627-86-1]

(862) HMDB Compounds for DGKE Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available

(6) Novoseek inferred chemical compound relationships for DGKE Gene

Compound -log(P) Hits PubMed IDs
lipid 40.4 3
ceramide 34.5 4
phosphoinositide 29.1 1
fatty acid 16 1
zinc 4.37 2
genes like me logo Genes that share compounds with DGKE: view

Transcripts for DGKE Gene

Unigene Clusters for DGKE Gene

Diacylglycerol kinase, epsilon 64kDa:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DGKE

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DGKE

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DGKE Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: -
SP2:
SP3:

Relevant External Links for DGKE Gene

GeneLoc Exon Structure for
DGKE
ECgene alternative splicing isoforms for
DGKE

Expression for DGKE Gene

mRNA expression in normal human tissues for DGKE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DGKE Gene

SOURCE GeneReport for Unigene cluster for DGKE Gene Hs.239514

mRNA Expression by UniProt/SwissProt for DGKE Gene

P52429-DGKE_HUMAN
Tissue specificity: Expressed predominantly in testis. Expressed in endothelium, platelets and podocytes (at protein level).
genes like me logo Genes that share expressions with DGKE: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DGKE Gene

Orthologs for DGKE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DGKE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DGKE 35
  • 99.35 (n)
  • 99.65 (a)
DGKE 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DGKE 35
  • 90.96 (n)
  • 93.79 (a)
DGKE 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DGKE 35
  • 91.43 (n)
  • 95.92 (a)
DGKE 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dgke 35
  • 87.23 (n)
  • 91.31 (a)
Dgke 16
Dgke 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DGKE 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DGKE 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves DGKE 35
  • 77.11 (n)
  • 79.42 (a)
DGKE 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DGKE 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dgke 35
  • 72.7 (n)
  • 78.68 (a)
zebrafish
(Danio rerio)
Actinopterygii dgke 35
  • 68.09 (n)
  • 72.07 (a)
dgke 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006768 35
  • 49.09 (n)
  • 42.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dgkepsilon 35
  • 48.26 (n)
  • 39.38 (a)
Dgkepsilon 36
  • 37 (a)
OneToOne
Dgkegr 37
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea dgk-2 35
  • 48.7 (n)
  • 40.04 (a)
dgk-2 36
  • 38 (a)
OneToOne
dgk-2 37
  • 35 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons DGK1 35
  • 47.29 (n)
  • 39.59 (a)
rice
(Oryza sativa)
Liliopsida Os12g0576900 35
  • 47.77 (n)
  • 38.46 (a)
Species with no ortholog for DGKE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DGKE Gene

ENSEMBL:
Gene Tree for DGKE (if available)
TreeFam:
Gene Tree for DGKE (if available)

Paralogs for DGKE Gene

Paralogs for DGKE Gene

Selected SIMAP similar genes for DGKE Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DGKE: view

Variants for DGKE Gene

Sequence variations from dbSNP and Humsavar for DGKE Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs166952 -- 56,840,280(+) TGTTA(A/G)GACAA intron-variant
rs1040261 -- 56,836,210(+) TTTTT(G/T)TAATT intron-variant
rs1992553 -- 56,868,309(-) GTTCA(A/G)ATCTG utr-variant-3-prime
rs1992554 -- 56,864,155(-) GCAGC(A/G)AACAA utr-variant-3-prime
rs2049061 -- 56,845,296(+) GAAAG(A/G)TCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DGKE Gene

Variant ID Type Subtype PubMed ID
nsv833495 CNV Loss 17160897
esv32884 CNV Loss 17666407
nsv908632 CNV Loss 21882294
esv2658087 CNV Deletion 23128226

Relevant External Links for DGKE Gene

HapMap Linkage Disequilibrium report
DGKE
Human Gene Mutation Database (HGMD)
DGKE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGKE Gene

Disorders for DGKE Gene

(1) OMIM Diseases for DGKE Gene (601440)

UniProtKB/Swiss-Prot

DGKE_HUMAN
  • Nephrotic syndrome 7 (NPHS7) [MIM:615008]: A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. NPHS7 is an autosomal recessive form characterized by onset of proteinuria usually in the first decade of life. The disorder is progressive, and some patients develop end-stage renal disease within several years. Renal biopsy typically shows membranoproliferative glomerulonephritis. {ECO:0000269 PubMed:23274426}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Hemolytic uremic syndrome atypical 7 (AHUS7) [MIM:615008]: An atypical form of hemolytic uremic syndrome characterized by acute onset in the first year of life of microangiopathic hemolytic anemia, thrombocytopenia, and renal failure. After the acute episode, most patients develop chronic renal insufficiency. Unlike other genetic forms of aHUS, AHUS7 is not related to abnormal activation of the complement system. {ECO:0000269 PubMed:23542698}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(1) Novoseek inferred disease relationships for DGKE Gene

Disease -log(P) Hits PubMed IDs
retinal degeneration 44 2

Relevant External Links for DGKE

Genetic Association Database (GAD)
DGKE
Human Genome Epidemiology (HuGE) Navigator
DGKE
genes like me logo Genes that share disorders with DGKE: view

Publications for DGKE Gene

  1. Molecular cloning of a novel human diacylglycerol kinase highly selective for arachidonate-containing substrates. (PMID: 8626589) Tang W. … Prescott S.M. (J. Biol. Chem. 1996) 2 3 4 23
  2. Characterization of the human diacylglycerol kinase epsilon gene and its assessment as a candidate for inherited retinitis pigmentosa. (PMID: 10571048) Tang W. … Prescott S.M. (Gene 1999) 3 4 23
  3. Role of the hydrophobic segment of diacylglycerol kinase epsilon. (PMID: 17455907) Dicu A.O. … Epand R.M. (Biochemistry 2007) 3 23
  4. Diacylglycerol kinase epsilon is selective for both acyl chains of phosphatidic acid or diacylglycerol. (PMID: 19744926) Lung M. … Epand R.M. (J. Biol. Chem. 2009) 3 23
  5. Cytogenetic assignment and physical mapping of the human DGKE gene to chromosome 17q22. (PMID: 10051413) Hart T.C. … Van Dyke T.E. (Genomics 1999) 2 3

Products for DGKE Gene

  • Addgene plasmids for DGKE

Sources for DGKE Gene

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