Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DGKD Gene

Aliases for DGKD Gene

  • Diacylglycerol Kinase, Delta 130kDa 2 3
  • Diglyceride Kinase Delta 3 4
  • DAG Kinase Delta 3 4
  • EC 4 63
  • DGK-Delta 3 4
  • Diacylglycerol Kinase, Delta (130kD) 2
  • 130 KDa Diacylglycerol Kinase 4
  • Diacylglycerol Kinase Delta 3
  • Diglyceride Kinase 2
  • DGKdelta 3
  • KIAA0145 4
  • Dgkd-2 3

External Ids for DGKD Gene

Previous GeneCards Identifiers for DGKD Gene

  • GC02P232271
  • GC02P232944
  • GC02P234279
  • GC02P234549
  • GC02P234045
  • GC02P233927
  • GC02P226097
  • GC02P234272

Summaries for DGKD Gene

Entrez Gene Summary for DGKD Gene

  • This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for DGKD Gene

DGKD (Diacylglycerol Kinase, Delta 130kDa) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include protein homodimerization activity and phospholipid binding. An important paralog of this gene is DGKI.

UniProtKB/Swiss-Prot for DGKD Gene

  • May function as signaling molecule.

  • Isoform 2 may be involved in cell growth and tumorigenesis. Involved in clathrin-dependent endocytosis.

Tocris Summary for DGKD Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes (DGKalpha, DGKbeta, DGKgamma, DGKdelta, DGKepsilon, DGKzeta, DGKeta, DGKtheta, DGKiota and DGKkappa) that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain, two cysteine-rich Zn2+-finger motifs that bind DAG and an ATP-binding site, whilst the regulatory domain varies. DGKs are widely distributed throughout mammalian tissues and different isozymes have different subcellular localizations; some are cytosolic (for example DGKalpha), some are membrane-bound (for example DGKgamma is associated with the Golgi membrane) and some are nuclear (for example DGKzeta. DGKs have diverse biological roles as they participate in signal transduction by modulating levels of DAG in a variety of cellular responses to extracellular stimuli.

Gene Wiki entry for DGKD Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGKD Gene

Genomics for DGKD Gene

Regulatory Elements for DGKD Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DGKD Gene

233,354,503 bp from pter
233,472,104 bp from pter
117,602 bases
Plus strand

Genomic View for DGKD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DGKD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKD Gene

Proteins for DGKD Gene

  • Protein details for DGKD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Diacylglycerol kinase delta
    Protein Accession:
    Secondary Accessions:
    • Q14158
    • Q6PK55
    • Q8NG53

    Protein attributes for DGKD Gene

    1214 amino acids
    Molecular mass:
    134525 Da
    Quaternary structure:
    • The two isoforms are able to form homo- and hetero-oligomer structures (at least tetramers). Isoform 2 interacts with AP2A2.

    Three dimensional structures from OCA and Proteopedia for DGKD Gene

    Alternative splice isoforms for DGKD Gene


neXtProt entry for DGKD Gene

Proteomics data for DGKD Gene at MOPED

Post-translational modifications for DGKD Gene

Other Protein References for DGKD Gene

Antibody Products

Domains for DGKD Gene

Suggested Antigen Peptide Sequences for DGKD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DAGKc domain.
  • Belongs to the eukaryotic diacylglycerol kinase family.
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
  • Contains 1 DAGKc domain.
  • Contains 1 PH domain.
  • Contains 1 SAM (sterile alpha motif) domain.
  • Belongs to the eukaryotic diacylglycerol kinase family.
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
genes like me logo Genes that share domains with DGKD: view

Function for DGKD Gene

Molecular function for DGKD Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Partially inhibited by phosphatidylserine
UniProtKB/Swiss-Prot Function:
May function as signaling molecule.
UniProtKB/Swiss-Prot Function:
Isoform 2 may be involved in cell growth and tumorigenesis. Involved in clathrin-dependent endocytosis.

Enzyme Numbers (IUBMB) for DGKD Gene

Gene Ontology (GO) - Molecular Function for DGKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003951 NAD+ kinase activity IEA --
GO:0004143 diacylglycerol kinase activity TAS 12200442
GO:0005515 protein binding IPI 23414517
GO:0005524 ATP binding IEA --
GO:0019992 diacylglycerol binding NAS 12200442
genes like me logo Genes that share ontologies with DGKD: view
genes like me logo Genes that share phenotypes with DGKD: view

Animal Models for DGKD Gene

MGI Knock Outs for DGKD:

Animal Model Products

miRNA for DGKD Gene

miRTarBase miRNAs that target DGKD

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DGKD

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for DGKD Gene

Localization for DGKD Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGKD Gene

Isoform 2: Cytoplasm.
Isoform 1: Membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for DGKD Gene COMPARTMENTS Subcellular localization image for DGKD gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for DGKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12200442
GO:0005886 plasma membrane TAS --
GO:0016023 cytoplasmic membrane-bounded vesicle IDA 12200442
genes like me logo Genes that share ontologies with DGKD: view

Pathways for DGKD Gene

genes like me logo Genes that share pathways with DGKD: view

Gene Ontology (GO) - Biological Process for DGKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0007165 signal transduction TAS 8626538
GO:0007173 epidermal growth factor receptor signaling pathway NAS 12200442
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway NAS 12200442
GO:0007275 multicellular organismal development NAS 12200442
genes like me logo Genes that share ontologies with DGKD: view

Drugs for DGKD Gene

(1) Drugbank Compounds for DGKD Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • Phosphatidyl-L-serine
8002-43-5 6323481 Target approved, nutraceutical

(1) Tocris Compounds for DGKD Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor [627-86-1]

(1422) HMDB Compounds for DGKD Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(Tetrahydrogen triphosphate) Adenosine
  • Adenosindiphosphorsaeure
  • 1-Myristoyl-3-myristoyl-sn-glycerol
  • 1-Myristoyl-3-myristoleoyl-sn-glycerol
  • 1-Myristoyl-3-pentadecanoyl-sn-glycerol

(4) Novoseek inferred chemical compound relationships for DGKD Gene

Compound -log(P) Hits PubMed IDs
diglyceride 96.4 13
ceramide 65.4 4
phosphatidylcholine 42.1 2
phospholipid 21.1 1
genes like me logo Genes that share compounds with DGKD: view

Transcripts for DGKD Gene

Unigene Clusters for DGKD Gene

Diacylglycerol kinase, delta 130kDa:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DGKD

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DGKD Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: - - -
SP2: - -

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b

Relevant External Links for DGKD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DGKD Gene

mRNA expression in normal human tissues for DGKD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DGKD Gene

This gene is overexpressed in Muscle - Skeletal (4.3).

Protein differential expression in normal tissues for DGKD Gene

This gene is overexpressed in Peripheral blood mononuclear cells (36.2), Heart (18.4), and Skin (14.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DGKD Gene

SOURCE GeneReport for Unigene cluster for DGKD Gene Hs.471675

mRNA Expression by UniProt/SwissProt for DGKD Gene

Tissue specificity: Isoform 2 is ubiquitously expressed also in tumor tissues. Isoform 1 is expressed in ovary, spleen and some tumor-derived cells.
genes like me logo Genes that share expressions with DGKD: view

Expression partners for DGKD Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for DGKD Gene

This gene was present in the common ancestor of animals.

Orthologs for DGKD Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DGKD 35
  • 86.88 (n)
  • 92.62 (a)
  • 93 (a)
(Canis familiaris)
Mammalia DGKD 35
  • 89.07 (n)
  • 95.25 (a)
  • 95 (a)
(Mus musculus)
Mammalia Dgkd 35
  • 86.88 (n)
  • 93.9 (a)
Dgkd 16
Dgkd 36
  • 94 (a)
(Pan troglodytes)
Mammalia DGKD 35
  • 99.51 (n)
  • 99.75 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Dgkd 35
  • 87.01 (n)
  • 93.72 (a)
(Monodelphis domestica)
Mammalia DGKD 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
-- 36
  • 79 (a)
-- 36
  • 98 (a)
(Gallus gallus)
Aves DGKD 35
  • 80.85 (n)
  • 89.94 (a)
  • 89 (a)
(Anolis carolinensis)
Reptilia DGKD 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dgkd 35
  • 72.09 (n)
  • 79.22 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13329 35
(Danio rerio)
Actinopterygii si:dkey-172j4.3 36
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34384 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea F42A9.1a 37
  • 38 (a)
F42A9.1b 37
  • 38 (a)
dgk-4 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2680 36
  • 49 (a)
Species with no ortholog for DGKD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DGKD Gene

Gene Tree for DGKD (if available)
Gene Tree for DGKD (if available)

Paralogs for DGKD Gene

Paralogs for DGKD Gene

(2) SIMAP similar genes for DGKD Gene using alignment to 6 proteins: Pseudogenes for DGKD Gene

genes like me logo Genes that share paralogs with DGKD: view

Variants for DGKD Gene

Sequence variations from dbSNP and Humsavar for DGKD Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2026 -- 233,472,020(+) ATTGT(C/T)ATGTA utr-variant-3-prime, nc-transcript-variant
rs706848 -- 233,391,273(-) TGATT(C/T)TGTGC intron-variant
rs750887 -- 233,421,480(+) agCTT(G/T)CATGG intron-variant
rs838705 -- 233,364,596(+) GTTGT(A/G)TGTAA intron-variant
rs838706 -- 233,367,846(+) TTTTT(C/T)TTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DGKD Gene

Variant ID Type Subtype PubMed ID
dgv495n27 CNV Loss 19166990
esv28401 CNV Loss 19812545
esv2657296 CNV Deletion 23128226
esv2721654 CNV Deletion 23290073
esv26406 CNV Gain 19812545
esv2721655 CNV Deletion 23290073
esv2663070 CNV Deletion 23128226
nsv876013 CNV Gain 21882294
esv1994590 CNV Deletion 18987734
esv2673713 CNV Deletion 23128226
esv2721656 CNV Deletion 23290073

Relevant External Links for DGKD Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGKD Gene

Disorders for DGKD Gene

Relevant External Links for DGKD

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for DGKD Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DGKD Gene

Publications for DGKD Gene

  1. Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases. (PMID: 8626538) Sakane F. … Kanoh H. (J. Biol. Chem. 1996) 2 3 4 23 25 26
  2. Alternative splicing of the human diacylglycerol kinase delta gene generates two isoforms differing in their expression patterns and in regulatory functions. (PMID: 12200442) Sakane F. … Kanoh H. (J. Biol. Chem. 2002) 3 4 23
  3. Nuclear diacylglycerol kinase-theta is activated in response to alpha-thrombin. (PMID: 11309392) Bregoli L. … Raben D.M. (J. Biol. Chem. 2001) 3 25 26
  4. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 3 4
  5. Identification and characterization of two splice variants of human diacylglycerol kinase eta. (PMID: 12810723) Murakami T. … Kanoh H. (J. Biol. Chem. 2003) 2 3

Products for DGKD Gene

Sources for DGKD Gene

Back to Top