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DGKD Gene

protein-coding   GIFtS: 67
GCID: GC02P234272

Diacylglycerol Kinase, Delta 130kDa

(Previous names: diacylglycerol kinase, delta (130kD))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Diacylglycerol Kinase, Delta 130kDa1 2     Diglyceride Kinase1
Diglyceride Kinase Delta2 3     DGKdelta2
DGK-delta2 3     dgkd-22
DAG Kinase Delta2 3     Diacylglycerol Kinase Delta2
EC 2.7.1.1073 8     130 KDa Diacylglycerol Kinase3
Diacylglycerol Kinase, Delta (130kD)1     KIAA01453

External Ids:    HGNC: 28511   Entrez Gene: 85272   Ensembl: ENSG000000770447   OMIM: 6018265   UniProtKB: Q167603   

Export aliases for DGKD gene to outside databases

Previous GC identifers: GC02P232271 GC02P232944 GC02P234279 GC02P234549 GC02P234045 GC02P233927 GC02P226097


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DGKD Gene:
This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid.
Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their
cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in
cellular signal transduction. Alternative splicing results in two transcript variants encoding different
isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for DGKD Gene:
DGKD (diacylglycerol kinase, delta 130kDa) is a protein-coding gene. Diseases associated with DGKD include hyperglycemia, and periodontitis. GO annotations related to this gene include phospholipid binding and protein homodimerization activity. An important paralog of this gene is DGKH.

UniProtKB/Swiss-Prot: DGKD_HUMAN, Q16760
Function: May function as signaling molecule
Function: Isoform 2 may be involved in cell growth and tumorigenesis. Involved in clathrin-dependent endocytosis

summary for DGKD Gene:
Diacylglycerol kinases (DGKs) are a group of ten enzymes (DGKalpha, DGKbeta, DGKgamma, DGKdelta, DGKepsilon,
DGKzeta, DGKeta, DGKtheta, DGKiota and DGKkappa) that metabolize 1,2,diacylglycerol (DAG) to produce
phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain, two cysteine-rich
Zn2+-finger motifs that bind DAG and an ATP-binding site, whilst the regulatory domain varies. DGKs are
widely distributed throughout mammalian tissues and different isozymes have different subcellular
localizations; some are cytosolic (for example DGKalpha), some are membrane-bound (for example DGKgamma is
associated with the Golgi membrane) and some are nuclear (for example DGKzeta. DGKs have diverse biological
roles as they participate in signal transduction by modulating levels of DAG in a variety of cellular
responses to extracellular stimuli.

Gene Wiki entry for DGKD Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DGKD gene promoter:
         RREB-1   HNF-4alpha2   POU6F1 (c2)   LCR-F1   GATA-1   HNF-4alpha1   E47   S8   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDGKD promoter sequence
   Search Chromatin IP Primers for DGKD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DGKD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37

DGKD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DGKD gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P234272:  view genomic region     (about GC identifiers)

Start:
234,263,153 bp from pter      End:
234,380,750 bp from pter
Size:
117,598 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DGKD_HUMAN, Q16760 (See protein sequence)
Recommended Name: Diacylglycerol kinase delta  
Size: 1214 amino acids; 134525 Da
Subunit: The two isoforms are able to form homo- and hetero-oligomer structures (at least tetramers). Isoform 2
interacts with AP2A2
2 PDB 3D structures from and Proteopedia for DGKD:
1R79 (3D)        3BQ7 (3D)    
Secondary accessions: Q14158 Q6PK55 Q8NG53
Alternative splicing: 2 isoforms:  Q16760-1   Q16760-2   

Explore the universe of human proteins at neXtProt for DGKD: NX_Q16760

Explore proteomics data for DGKD at MOPED

Post-translational modifications: 

  • Isoform 1 H domain is phosphorylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DGKD (Q16760) (see all 15)
     MWYGVLG  LEVVAVF  HHRIAQC  EGNLPVS 


    See DGKD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_003639.2  NP_690618.2  

    ENSEMBL proteins: 
     ENSP00000264057   ENSP00000407938   ENSP00000395530   ENSP00000386455   ENSP00000390970  
    Reactome Protein details: Q16760

    DGKD Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    SAMD: Sterile alpha motif (SAM) domain containing

    Selected InterPro protein domains (see all 9):
     IPR001206 Diacylglycerol_kinase_cat_dom
     IPR001849 Pleckstrin_homology
     IPR000756 Diacylglycerol_kin_accessory
     IPR011993 PH_like_dom
     IPR013761 SAM/pointed

    Graphical View of Domain Structure for InterPro Entry Q16760

    ProtoNet protein and cluster: Q16760

    5 Blocks protein domains:
    IPB000756 Diacylglycerol kinase accessory domain (presumed)
    IPB001660 Sterile alpha motif SAM
    IPB001849 Pleckstrin-like
    IPB002219 Protein kinase C
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: DGKD_HUMAN, Q16760
    Similarity: Belongs to the eukaryotic diacylglycerol kinase family
    Similarity: Contains 1 DAGKc domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    DGKD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DGKD_HUMAN, Q16760
    Function: May function as signaling molecule
    Function: Isoform 2 may be involved in cell growth and tumorigenesis. Involved in clathrin-dependent endocytosis
    Catalytic activity: ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate
    Enzyme regulation: Partially inhibited by phosphatidylserine

         Enzyme Number (IUBMB): EC 2.7.1.1071 2

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003951NAD+ kinase activity IEA--
    GO:0004143diacylglycerol kinase activity TAS12200442
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0019992diacylglycerol binding NAS12200442
         
    DGKD for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DGKD:
     Increased cell death HMECs cel 

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dgkd):
     behavior/neurological  growth/size/body  homeostasis/metabolism  integument  mortality/aging 
     nervous system  respiratory system  tumorigenesis  vision/eye 

    DGKD for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dgkdtm1Mtop for DGKD

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DGKD
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DGKD

    miRNA
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    miRTarBase miRNAs that target DGKD:
    hsa-mir-375 (MIRT019754), hsa-mir-106b-5p (MIRT044251), hsa-mir-877-5p (MIRT037279)

    Block miRNA regulation of human, mouse, rat DGKD using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DGKD (see all 19):
    hsa-miR-30c hsa-miR-300 hsa-miR-658 hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-30d hsa-miR-515-5p
    SwitchGear 3'UTR luciferase reporter plasmidDGKD 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DGKD
    Predesigned siRNA for gene silencing in human, mouse, rat DGKD

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): DGKD (NM_152879)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGKD


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DGKD_HUMAN, Q16760: Isoform 2: Cytoplasm
    DGKD_HUMAN, Q16760: Isoform 1: Membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    nucleus3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA12200442
    GO:0005886plasma membrane TAS--
    GO:0016023cytoplasmic membrane-bounded vesicle IDA12200442

    DGKD for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DGKD About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    3Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    4Glycerophospholipid biosynthesis
    Glycerophospholipid metabolism0.62
    5Inositol phosphate metabolism (KEGG)
    Phosphatidylinositol signaling system0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for DGKD
        Effects of PIP2 hydrolysis


    4 Kegg Pathways  (Kegg details for DGKD):
        Glycerolipid metabolism
    Glycerophospholipid metabolism
    Metabolic pathways
    Phosphatidylinositol signaling system


    DGKD for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DGKD
    Interactions:

        Search GeneGlobe Interaction Network for DGKD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DGKD (Q167601, 2, 3 ENSP000002640574) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HAX1O001652, 3, ENSP000003290024MINT-64293 I2D: score=5 STRING: ENSP00000329002
    IGSF21Q96ID52, 3, ENSP000002512964MINT-64294 I2D: score=4 STRING: ENSP00000251296
    TNFRSF14Q929562, 3, ENSP000003479484MINT-8274467 I2D: score=2 STRING: ENSP00000347948
    DGKHQ86XP13, ENSP000003375724I2D: score=2 STRING: ENSP00000337572
    MYH2Q9UKX23, ENSP000002455034I2D: score=1 STRING: ENSP00000245503
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--
    GO:0007165signal transduction TAS8626538
    GO:0007173epidermal growth factor receptor signaling pathway NAS12200442
    GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway NAS12200442
    GO:0007275multicellular organismal development NAS12200442

    DGKD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for DGKD available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DioctanoylglycolDiacylglycerol kinase inhibitor[627-86-1]

    Selected HMDB Compounds for DGKD (see all 986)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----

    1 DrugBank Compound for DGKD    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Phosphatidylserine3-O-sn-Phosphatidyl-L-serine (see all 3)8002-43-5target--11309392 17139284 17016423 8626538

    4 Novoseek inferred chemical compound relationships for DGKD gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diglyceride 96.4 18 7506208 (1), 10366848 (1), 1988442 (1), 2283681 (1) (see all 13)
    ceramide 65.4 6 10366848 (1), 9837889 (1), 11070860 (1), 9305886 (1)
    phosphatidylcholine 42.1 2 1988442 (1), 1939084 (1)
    phospholipid 21.1 1 7506208 (1)



    DGKD for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DGKD gene (2 alternative transcripts): 
    NM_003648.2  NM_152879.2  

    Unigene Cluster for DGKD:

    Diacylglycerol kinase, delta 130kDa
    Hs.471675  [show with all ESTs]
    Unigene Representative Sequence: NM_152879
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264057(uc002vui.1) ENST00000427930 ENST00000447484 ENST00000489613
    ENST00000409813(uc002vuj.1) ENST00000472732 ENST00000490764(uc010fyh.1)
    ENST00000474488(uc002vuk.1) ENST00000430834(uc010fyi.1) ENST00000480535
    ENST00000465569 ENST00000471764 ENST00000495901
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    hsa-miR-30c hsa-miR-300 hsa-miR-658 hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-30d hsa-miR-515-5p
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    Additional mRNA sequence: 

    AK130440.1 AK307426.1 AK308846.1 AK311044.1 BC006561.2 BC032102.2 D63479.3 

    15 DOTS entries:

    DT.95370050  DT.100791385  DT.100031067  DT.91995981  DT.95089641  DT.102823462  DT.86840965  DT.100662285 
    DT.120974859  DT.91760911  DT.95313346  DT.95336240  DT.95370056  DT.101971464  DT.448982 

    Selected AceView cDNA sequences (see all 237):

    AI360507 NM_003648 NM_152879 BQ882192 BQ053494 BQ772657 CB851066 CB853463 
    CR624948 BU529069 BQ931888 BQ934762 AA323606 BM673632 BC006561 BQ958501 
    AI916987 AA025229 BQ936532 BM670646 BQ933869 CA426001 AI201114 BC032102 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DGKD    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:        -                 -                                                                                                     -                           
    SP2:                          -                                                                                                     -                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b
    SP1:                                                      
    SP2:                                                      
    SP3:                                                      
    SP4:                                                      


    ECgene alternative splicing isoforms for DGKD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    DGKD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACATAGTCC
    DGKD Expression
    About this image


    DGKD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Cardiovascular System)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Brain (Nervous System)
             Cerebellum
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Stomach (Gastrointestinal Tract)
    DGKD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DGKD Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.471675

    UniProtKB/Swiss-Prot: DGKD_HUMAN, Q16760
    Tissue specificity: Isoform 2 is ubiquitously expressed also in tumor tissues. Isoform 1 is expressed in ovary,
    spleen and some tumor-derived cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DGKD gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dgkd1 , 5 diacylglycerol kinase, delta1, 5 86.88(n)1
    93.9(a)1
      1 (44.44 cM)5
    2273331  NM_177646.31  NP_808314.21 
     878532875 
    chicken
    (Gallus gallus)
    Aves DGKD1 diacylglycerol kinase, delta 130kDa 80.85(n)
    89.94(a)
      424747  XM_004936945.1  XP_004937002.1 
    lizard
    (Anolis carolinensis)
    Reptilia DGKD6
    diacylglycerol kinase, delta 130kDa
    88(a)
    1 ↔ 1
    3(35988944-36073294)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.133292 Xenopus laevis transcribed sequence with moderate similarity more 79.48(n)    CD325394.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-172j4.36
    si:dkey-172j4.3
    64(a)
    many ↔ many
    7(24747232-24892890) ENSDARG00000074183
    fruit fly
    (Drosophila melanogaster)
    Insecta CG343846
    --
    30(a)
    1 → many
    3R(3640083-3680507)
    worm
    (Caenorhabditis elegans)
    Secernentea F42A9.1b3 kinase 38(a)
    (best of 2)
      IV(8631619-8643503)   --


    ENSEMBL Gene Tree for DGKD (if available)
    TreeFam Gene Tree for DGKD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DGKD gene
    DGKH2  DGKQ2  DGKB2  DGKI2  DGKE2  DGKZ2  DGKA2  DGKG2  
    2 SIMAP similar genes for DGKD using alignment to 6 protein entries:     DGKD_HUMAN (see all proteins):
    DGKH    DGKK

    DGKD for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DGKD
    PGOHUM00000241294


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DGKD (see all 2797)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs739959171,2
    C,F--233634008(+) TCCAGG/CGTTTT 1 -- us2k12Minor allele frequency- C:0.05WA 120
    rs1456775641,2
    --233634097(+) TGCATC/GAGTTC 1 -- us2k10--------
    rs1807984261,2
    --233634135(+) AGGCCA/GGGCGG 1 -- us2k10--------
    rs1862614571,2
    --233634252(+) GCCATC/TTTCTC 1 -- us2k10--------
    rs1999987781,2
    C--233634281(+) CTGCC-/CTCTGTG 1 -- us2k10--------
    rs1893755991,2
    --233634308(+) ATCTCC/TTCTTT 1 -- us2k10--------
    rs1477153571,2
    --233634374(+) CTTCAC/TTACCT 1 -- us2k10--------
    rs1813985161,2
    --233634378(+) ATTACC/GTTTTT 1 -- us2k10--------
    rs1865957951,2
    --233634637(+) AGTAGC/TCACAT 1 -- us2k10--------
    rs11078131,2
    C--233634712(+) CCTTAA/GGCCTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DGKD (234263153 - 234380750 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DGKD (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663070CNV Deletion23128226
    esv2721655CNV Deletion23290073
    esv2657296CNV Deletion23128226
    esv2721654CNV Deletion23290073
    esv2673713CNV Deletion23128226
    esv2721656CNV Deletion23290073
    esv1994590CNV Deletion18987734
    dgv495n27CNV Loss19166990
    esv28401CNV Loss19812545
    nsv876013CNV Gain21882294

    Human Gene Mutation Database (HGMD): DGKD
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601826    OMIM disorders: --

    5 diseases for DGKD:    
    About MalaCards
    hyperglycemia    periodontitis    crohn's disease    insulin resistance
    parkinson's disease


    DGKD for disorders           About GeneDecksing

    Genetic Association Database (GAD): DGKD
    Human Genome Epidemiology (HuGE) Navigator: DGKD (1 document)

    Export disorders for DGKD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DGKD gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with DGKD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases. (PubMed id 8626538)1, 2, 3, 7, 9 Sakane F.... Kanoh H. (J. Biol. Chem. 1996)
    2. Alternative splicing of the human diacylglycerol kinase delta gene generates two isoforms differing in their expression patterns and in regulatory functions. (PubMed id 12200442)1, 2, 9 Sakane F.... Kanoh H. (J. Biol. Chem. 2002)
    3. Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels. (PubMed id 20705733)1, 4 O'Seaghdha C.M....KAPttgen A. (Hum. Mol. Genet. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Identification and characterization of two splice variants of human diacylglycerol kinase eta. (PubMed id 12810723)1, 3 Murakami T.... Kanoh H. (J. Biol. Chem. 2003)
    7. Phorbol ester-regulated oligomerization of diacylglycerol kinase delta linked to its phosphorylation and translocation. (PubMed id 12084710)1, 2 Imai S.... Kanoh H. (J. Biol. Chem. 2002)
    8. Nuclear diacylglycerol kinase-theta is activated in response to alpha-thrombin. (PubMed id 11309392)1, 7 Bregoli L....Raben D.M. (J. Biol. Chem. 2001)
    9. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2 Nagase T.... Nomura N. (DNA Res. 1995)
    10. Regulation of enzyme localization by polymerization: polymer formation by the SAM domain of diacylglycerol kinase delta1. (PubMed id 18334213)1, 9 Harada B.T....Bowie J.U. (Structure 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8527 HGNC: 2851 AceView: DGKD Ensembl:ENSG00000077044 euGenes: HUgn8527
    ECgene: DGKD Kegg: 8527 H-InvDB: DGKD

    (According to HUGE)
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    HUGE: KIAA0145

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DGKD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DGKD gene:
    Search GeneIP for patents involving DGKD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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