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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DGKD Gene

protein-coding   GIFtS: 65
GCID: GC02P234279

diacylglycerol kinase, delta 130kDa

(Previous names: diacylglycerol kinase, delta (130kD) )
 Explore 5 diseases affiliated with
DGKD via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DGKD    

Aliases
for DGKD gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Diacylglycerol Kinase, Delta 130kDa1 2     EC 2.7.1.1073 8
DGKdelta1 2     Diacylglycerol Kinase, Delta (130kD)1
KIAA01451 3     Dgkd-21
Diglyceride Kinase Delta2 3     Diacylglycerol Kinase Delta2
DGK-Delta1     130 KDa Diacylglycerol Kinase3
DAG Kinase Delta2 3     

External Ids:    HGNC: 28511   Entrez Gene: 85272   Ensembl: ENSG000000770447   OMIM: 6018265   UniProtKB: Q167603   

Export aliases for DGKD gene to outside databases

Previous GC identifers: GC02P232271 GC02P232944 GC02P234549 GC02P234045 GC02P233927 GC02P226097


Summaries
for DGKD gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DGKD:
This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol
and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular
concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal
transduction. Alternative splicing results in two transcript variants encoding different isoforms. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DGKD_HUMAN, Q16760
Function: May function as signaling molecule
Function: Isoform 2 may be involved in cell growth and tumorigenesis. Involved in clathrin-dependent endocytosis

summary for DGKD:
Diacylglycerol kinases (DGKs) are a group of ten enzymes (DGKalpha, DGKbeta, DGKgamma, DGKdelta, DGKepsilon,
DGKzeta, DGKeta, DGKtheta, DGKiota and DGKkappa) that metabolize 1,2,diacylglycerol (DAG) to produce
phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain, two cysteine-rich
Zn2+-finger motifs that bind DAG and an ATP-binding site, whilst the regulatory domain varies. DGKs are
widely distributed throughout mammalian tissues and different isozymes have different subcellular
localizations; some are cytosolic (for example DGKalpha), some are membrane-bound (for example DGKgamma is
associated with the Golgi membrane) and some are nuclear (for example DGKzeta. DGKs have diverse biological
roles as they participate in signal transduction by modulating levels of DAG in a variety of cellular
responses to extracellular stimuli.

Gene Wiki entry for DGKD


Genomic Views
for DGKD gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005120.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DGKD gene promoter:
         RREB-1   HNF-4alpha2   POU6F1 (c2)   LCR-F1   GATA-1   HNF-4alpha1   E47   S8   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DGKD promoter sequence
   Search SABiosciences Chromatin IP Primers for DGKD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DGKD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37

DGKD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DGKD gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P234279:  view genomic region     (about GC identifiers)

Start:
 234,263,153 bp from pter      End:
 234,380,750 bp from pter
Size:
 117,598 bases      Orientation:
 plus strand

Proteins
for DGKD gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DGKD_HUMAN, Q16760 (See protein sequence)
Recommended Name: Diacylglycerol kinase delta  
Size: 1214 amino acids; 134525 Da
Subunit: The two isoforms are able to form homo- and hetero-oligomer structures (at least tetramers). Isoform 2
interacts with AP2A2
Subcellular location: Isoform 2: Cytoplasm
Subcellular location: Isoform 1: Membrane; Peripheral membrane protein
2 PDB 3D structures from and Proteopedia for DGKD:
1R79 (3D)        3BQ7 (3D)    
Secondary accessions: Q14158 Q6PK55 Q8NG53
Alternative splicing: 2 isoforms:  Q16760-1   Q16760-2   

Explore the universe of human proteins at neXtProt for DGKD: NX_Q16760

Post-translational modifications:

  • Isoform 1 H domain is phosphorylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16760

    • 4/15 DME Specific Peptides for DGKD (Q16760) (see all 15)
     MWYGVLG  LEVVAVF  HHRIAQC  EGNLPVS 

    DGKD Protein expression data from MOPED and PaxDb:    About this image 
    DGKD Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_003639.2  NP_690618.2  

    ENSEMBL proteins: 
     ENSP00000264057   ENSP00000407938   ENSP00000395530   ENSP00000386455   ENSP00000390970  
    Reactome Protein details: Q16760
    Human Recombinant Protein Products for DGKD: 
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA12200442
    GO:0005886plasma membrane TAS--
    GO:0016023cytoplasmic membrane-bounded vesicle IDA12200442

    DGKD for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for DGKD gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DGKD for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR001206 Diacylglycerol_kinase_cat_dom
     IPR002219 Prot_Kinase_C-like_PE/DAG-bd
     IPR000756 Diacylglycerol_kin_accessory
     IPR013761 SAM/pointed
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q16760

    ProtoNet protein and cluster: Q16760

    5 Blocks protein families:
    IPB000756 Diacylglycerol kinase accessory domain (presumed)
    IPB001660 Sterile alpha motif SAM
    IPB001849 Pleckstrin-like
    IPB002219 Protein kinase C
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: DGKD_HUMAN, Q16760
    Similarity: Belongs to the eukaryotic diacylglycerol kinase family
    Similarity: Contains 1 DAGKc domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Function
    for DGKD gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DGKD_HUMAN, Q16760
    Function: May function as signaling molecule
    Function: Isoform 2 may be involved in cell growth and tumorigenesis. Involved in clathrin-dependent endocytosis
    Catalytic activity: ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate
    Enzyme regulation: Partially inhibited by phosphatidylserine

         Enzyme Number (IUBMB): EC 2.7.1.1071 2

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004143diacylglycerol kinase activity TAS12200442
    GO:0005524ATP binding IEA--
    GO:0005543phospholipid binding IEA--
    GO:0019992diacylglycerol binding NAS12200442
    GO:0042803protein homodimerization activity IDA12200442
         
    DGKD for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DGKD:
     Increased cell death HMECs cel 

         9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Dgkd):
     behavior/neurological  growth/size  homeostasis/metabolism  integument  mortality/aging 
     nervous system  respiratory system  tumorigenesis  vision/eye 

    DGKD for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Dgkdtm1Mtop for DGKD
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DGKD 

    miRNA
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    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate DGKD (see all 19):
    hsa-miR-30c hsa-miR-300 hsa-miR-658 hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-30d hsa-miR-515-5p
    SwitchGear 3'UTR luciferase reporter plasmid: DGKD 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of DGKD 
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    Clone
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    In Situ Assay
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    Pathways & Interactions
    for DGKD gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    2Platelet activation, signaling and aggregation
    		Platelet activation, signaling and aggregation1.00
    		Hemostasis0.43
    3G alpha (q) signalling events
    		G alpha (q) signalling events1.00
    		Gastrin-CREB signalling pathway via PKC and MAPK0.90
    4Effects of PIP2 hydrolysis
    		Effects of PIP2 hydrolysis1.00
    5Glycerolipid metabolism
    		Glycerolipid metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/8        Reactome Pathways for DGKD (see all 8)
        GPCR downstream signaling
    Hemostasis
    Effects of PIP2 hydrolysis
    Signal Transduction
    Gastrin-CREB signalling pathway via PKC and MAPK


    4         Kegg Pathways  (Kegg details for DGKD):
        Glycerolipid metabolism
    Glycerophospholipid metabolism
    Metabolic pathways
    Phosphatidylinositol signaling system


    DGKD for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DGKD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/48 Interacting proteins for DGKD (Q167601, 2, 3 ENSP000002640574) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HAX1O001652, 3, ENSP000003290024MINT-64293 I2D: score=5 STRING: ENSP00000329002
    IGSF21Q96ID52, 3, ENSP000002512964MINT-64294 I2D: score=4 STRING: ENSP00000251296
    TNFRSF14Q929562, 3, ENSP000003479484MINT-8274467 I2D: score=2 STRING: ENSP00000347948
    DGKHQ86XP13, ENSP000003375724I2D: score=2 STRING: ENSP00000337572
    MYH2Q9UKX23, ENSP000002455034I2D: score=1 STRING: ENSP00000245503
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--
    GO:0007165signal transduction TAS8626538
    GO:0007173epidermal growth factor receptor signaling pathway NAS12200442
    GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway NAS12200442
    GO:0007275multicellular organismal development NAS12200442

    DGKD for ontologies           About GeneDecksing



    Drugs & Compounds
    for DGKD gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DGKD for compounds           About GeneDecksing

    EMD Millipore small molecules for DGKD:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for DGKD available from Tocris Bioscience    About this table
    CompoundAction CAS #
    R 59-022Diacylglycerol kinase inhibitor; increases PKC activity[93076-89-2]
    DioctanoylglycolDiacylglycerol kinase inhibitor[627-86-1]

    10/986 HMDB Compounds for DGKD (see all 986)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----

    1 DrugBank Compound for DGKD    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Phosphatidylserine3-O-sn-Phosphatidyl-L-serine (see all 3)8002-43-5target--11309392 17139284 17016423 8626538

    4 Novoseek chemical compound relationships for DGKD gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diglyceride 96.4 18 7506208 (1), 10366848 (1), 1988442 (1), 2283681 (1) (see all 13)
    ceramide 65.4 6 10366848 (1), 9837889 (1), 11070860 (1), 9305886 (1)
    phosphatidylcholine 42.1 2 1988442 (1), 1939084 (1)
    phospholipid 21.1 1 7506208 (1)

    Search CenterWatch for drugs/clinical trials and news about DGKD 

    Transcripts
    for DGKD gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DGKD gene (2 alternative transcripts): 
    NM_003648.2  NM_152879.2  

    Unigene Cluster for DGKD:

    Diacylglycerol kinase, delta 130kDa
    Hs.471675  [show with all ESTs]
    Unigene Representative Sequence: NM_152879
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264057(uc002vui.1) ENST00000427930 ENST00000447484 ENST00000489613
    ENST00000409813(uc002vuj.1) ENST00000472732 ENST00000490764(uc010fyh.1)
    ENST00000474488(uc002vuk.1) ENST00000430834(uc010fyi.1) ENST00000480535
    ENST00000465569 ENST00000471764 ENST00000495901

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    Inhib. RNA
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    Additional cDNA sequence: 

    AK130440.1 AK307426.1 AK308846.1 AK311044.1 BC006561.2 BC032102.2 D63479.3 

    15 DOTS entries:

    DT.95370050  DT.100791385  DT.100031067  DT.91995981  DT.95089641  DT.102823462  DT.86840965  DT.100662285 
    DT.120974859  DT.91760911  DT.95313346  DT.95336240  DT.95370056  DT.101971464  DT.448982 

    24/237 AceView cDNA sequences (see all 237):

    CB851066 CB853463 CR624948 BU529069 BQ931888 BQ934762 AA323606 BM673632 
    BC006561 BQ958501 AI916987 AA025229 BQ936532 BM670646 BQ933869 CA426001 
    BC032102 AI201114 D63479 BM907834 BG386823 AK130440 BQ772657 CB240924 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DGKD    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:        -                 -                                                                                                     -                           
    SP2:                          -                                                                                                     -                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b
    SP1:                                                      
    SP2:                                                      
    SP3:                                                      
    SP4:                                                      


    ECgene alternative splicing isoforms for DGKD

    Expression
    for DGKD gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DGKD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACATAGTCC
    DGKD Expression
    About this image
    See DGKD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DGKD

    SOURCE GeneReport for Unigene cluster: Hs.471675

    UniProtKB/Swiss-Prot: DGKD_HUMAN, Q16760
    Tissue specificity: Isoform 2 is ubiquitously expressed also in tumor tissues. Isoform 1 is expressed in ovary, spleen
    and some tumor-derived cells

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    Orthologs
    for DGKD gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DGKD gene from 8/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DGKD1 diacylglycerol kinase, delta 130kDa 80.81(n)
    89.73(a)    		   424747  XM_422569.3  XP_422569.3 
    lizard
    (Anolis carolinensis)    		 Reptilia DGKD6
    		 --
    		 85(a)
    		 1 ↔ 1
    		 3(35989041-36069608)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.133292 Xenopus laevis transcribed sequence with moderate similarity more 79.48(n)    CD325394.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii dgkd1 diacylglycerol kinase, delta 130kDa 76.46(n)
    92.1(a)    		   100536469  XM_003200100.1  XP_003200148.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG343846
    		 --
    		 29(a)
    		 1 → many
    		 3R(3640083-3680507)
    worm
    (Caenorhabditis elegans)    		 Secernentea F42A9.1a3
    dgk-41    		 kinase3
    Protein DGK-41    		 38(a)
    (best of 2)3
    48.99(n)1
    45.55(a)1    		   IV(8631619-8643503)3
    1776671  NM_069075.21  NP_501476.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons DGK26
    DGK16
    (see all 7)    		 diacylglycerol kinase1
    (see all 7)    		 25(a)
    24(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 5(25518641-25523621)
    5(2524778-2529330)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 8)    		 diacylglycerol kinase 1, putative, expressed
    (see all 8)    		 26(a)
    25(a)
    (see all 8)    		 many ↔ many
    many ↔ many
    (see all 8)    		 12(6728516-6733263)
    3(17753599-17759915)


    ENSEMBL Gene Tree for DGKD (if available)
    TreeFam Gene Tree for DGKD (if available) 

    Paralogs
    for DGKD gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DGKD gene
    DGKA2  DGKH2  DGKQ2  DGKG2  DGKB2  DGKI2  DGKE2  DGKZ2  
    2 SIMAP similar genes for DGKD using alignment to 6 protein entries:     DGKD_HUMAN (see all proteins):
    DGKH    DGKK

    DGKD for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DGKD
    PGOHUM00000241294


    Genomic Variants
    for DGKD gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2241 NCBI SNPs in DGKD are shown (see all 2241)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs739959171,2
    		C--234261175(+) TCCAGG/CGTTTT 1 -- us2k12Minor allele frequency- C:0.05WA 120
    rs1456775641,2
    		--234261264(+) TGCATC/GAGTTC 1 -- us2k10--------
    rs1807984261,2
    		--234261302(+) AGGCCA/GGGCGG 1 -- us2k10--------
    rs1862614571,2
    		--234261419(+) GCCATC/TTTCTC 1 -- us2k10--------
    rs1999987781,2
    		--234261448(+) CTGCC-/CTCTGTG 1 -- us2k10--------
    rs1893755991,2
    		--234261475(+) ATCTCC/TTCTTT 1 -- us2k10--------
    rs1477153571,2
    		--234261541(+) CTTCAC/TTACCT 1 -- us2k10--------
    rs1813985161,2
    		--234261545(+) ATTACC/GTTTTT 1 -- us2k10--------
    rs1865957951,2
    		--234261804(+) AGTAGC/TCACAT 1 -- us2k10--------
    rs11078131,2
    		C--234261879(+) CCTTAA/GGCCTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DGKD (234263153 - 234380750 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for DGKD
         5 CNVs: 79019 90339 53177 79018 90338
         3 Indels: 45964 68248 68244
    Human Gene Mutation Database (HGMD): DGKD

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    Disorders / Diseases
    for DGKD gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DGKD for disorders           About GeneDecksing

    OMIM gene information: 601826    OMIM disorders: --

    5 diseases for DGKD:    About MalaCards
    insulin resistance    hyperglycemia    seizures    periodontitis
    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: DGKD (1 document)

    Export disorders for DGKD gene to outside databases

    Publications
    for DGKD gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DGKD gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with DGKD)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases. (PubMed id 8626538)1, 2, 3, 7, 9 Sakane F.... Kanoh H. (1996)
    2. Alternative splicing of the human diacylglycerol kinase delta gene generates two isoforms differing in their expression patterns and in regulatory functions. (PubMed id 12200442)1, 2, 9 Sakane F.... Kanoh H. (2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Identification and characterization of two splice variants of human diacylglycerol kinase eta. (PubMed id 12810723)1, 3 Murakami T.... Kanoh H. (2003)
    5. Phorbol ester-regulated oligomerization of diacylglycerol kinase delta linked to its phosphorylation and translocation. (PubMed id 12084710)1, 2 Imai S.... Kanoh H. (2002)
    6. Nuclear diacylglycerol kinase-theta is activated in response to alpha-thrombin. (PubMed id 11309392)1, 7 Bregoli L....Raben D.M. (2001)
    7. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2 Nagase T....Nomura N. (1995)
    8. Regulation of enzyme localization by polymerization: polymer formation by the SAM domain of diacylglycerol kinase delta1. (PubMed id 18334213)1, 9 Harada B.T....Bowie J.U. (2008)
    9. Regulation of clathrin-dependent endocytosis by diacylglycerol kinase delta: importance of kinase activity and binding to AP2alpha. (PubMed id 17880279)2, 9 Kawasaki T....Saito N. (2008)
    10. Analysis of the genotype of diacylglycerol kinase delt a single-nucleotide polymorphisms in Parkinson disease in the Han Chinese popula tion. (PubMed id 22406787)1 Song W....Shang H.F. (2012)

    External Searches for DGKD gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DGKD gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8527 HGNC: 2851 AceView: DGKD Ensembl:ENSG00000077044 euGenes: HUgn8527
    ECgene: DGKD Kegg: 8527 H-InvDB: DGKD

    Other Databases showing DGKD gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0145

    Specialized Databases showing DGKD gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DGKD Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DGKD gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DGKD gene:
    Search GeneIP for patents involving DGKD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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