Aliases for DGKD Gene
External Ids for DGKD Gene
Previous GeneCards Identifiers for DGKD Gene
This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for DGKD Gene
DGKD (Diacylglycerol Kinase, Delta 130kDa) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include protein homodimerization activity and phospholipid binding. An important paralog of this gene is DGKI.
UniProtKB/Swiss-Prot for DGKD Gene
May function as signaling molecule.
Isoform 2 may be involved in cell growth and tumorigenesis. Involved in clathrin-dependent endocytosis.
Diacylglycerol kinases (DGKs) are a group of ten enzymes (DGKalpha, DGKbeta, DGKgamma, DGKdelta, DGKepsilon, DGKzeta, DGKeta, DGKtheta, DGKiota and DGKkappa) that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain, two cysteine-rich Zn2+-finger motifs that bind DAG and an ATP-binding site, whilst the regulatory domain varies. DGKs are widely distributed throughout mammalian tissues and different isozymes have different subcellular localizations; some are cytosolic (for example DGKalpha), some are membrane-bound (for example DGKgamma is associated with the Golgi membrane) and some are nuclear (for example DGKzeta. DGKs have diverse biological roles as they participate in signal transduction by modulating levels of DAG in a variety of cellular responses to extracellular stimuli.