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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DGKB Gene

protein-coding   GIFtS: 65
GCID: GC07M014153

Diacylglycerol Kinase, Beta 90kDa

(Previous names: diacylglycerol kinase, beta (90kD))
(Previous symbol: DAGK2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Diacylglycerol Kinase, Beta 90kDa1 2     KIAA07183 5
DAGK21 2 3     Diacylglycerol Kinase, Beta (90kD)1
Diglyceride Kinase Beta2 3     DGK-BETA2
90 KDa Diacylglycerol Kinase2 3     Diacylglycerol Kinase Beta2
DAG Kinase Beta2 3     DGK-beta3
EC 2.7.1.1073 8     EC 2.7.18
DGK2 5     

External Ids:    HGNC: 28501   Entrez Gene: 16072   Ensembl: ENSG000001362677   OMIM: 6040705   UniProtKB: Q9Y6T73   

Export aliases for DGKB gene to outside databases

Previous GC identifers: GC07M013831 GC07M013931 GC07M013960 GC07M014066


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DGKB Gene:
Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger
diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been
identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase)
domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta
isotype. Two alternatively spliced transcript variants have been found for this gene. (provided by RefSeq, Jul
2008)

GeneCards Summary for DGKB Gene: 
DGKB (diacylglycerol kinase, beta 90kDa) is a protein-coding gene. Diseases associated with DGKB include aggressive periodontitis, and retinal degeneration, and among its related super-pathways are Signaling by GPCR and Gastrin-CREB signalling pathway via PKC and MAPK. GO annotations related to this gene include diacylglycerol kinase activity and calcium ion binding. An important paralog of this gene is DGKH.

UniProtKB/Swiss-Prot: DGKB_HUMAN, Q9Y6T7
Function: Exhibits high phosphorylation activity for long-chain diacylglycerols (By similarity)

summary for DGKB Gene:
Diacylglycerol kinases (DGKs) are a group of ten enzymes (DGKalpha, DGKbeta, DGKgamma, DGKdelta, DGKepsilon,
DGKzeta, DGKeta, DGKtheta, DGKiota and DGKkappa) that metabolize 1,2,diacylglycerol (DAG) to produce
phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain, two cysteine-rich
Zn2+-finger motifs that bind DAG and an ATP-binding site, whilst the regulatory domain varies. DGKs are
widely distributed throughout mammalian tissues and different isozymes have different subcellular
localizations; some are cytosolic (for example DGKalpha), some are membrane-bound (for example DGKgamma is
associated with the Golgi membrane) and some are nuclear (for example DGKzeta. DGKs have diverse biological
roles as they participate in signal transduction by modulating levels of DAG in a variety of cellular
responses to extracellular stimuli.

Gene Wiki entry for DGKB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DGKB gene promoter:
         AML1a   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   NF-E2 p45   YY1   FOXL1   POU2F1   POU2F1a   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): DGKB promoter sequence
   Search SABiosciences Chromatin IP Primers for DGKB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DGKB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p21.2   Ensembl cytogenetic band:  7p21.2   HGNC cytogenetic band: 7p21.2

DGKB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DGKB gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M014153:  view genomic region     (about GC identifiers)

Start:
14,184,674 bp from pter      End:
15,014,402 bp from pter
Size:
829,729 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 14,235,562-14,932,596     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DGKB_HUMAN, Q9Y6T7 (See protein sequence)
Recommended Name: Diacylglycerol kinase beta  
Size: 804 amino acids; 90595 Da
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AAS07533.1; Type=Erroneous gene model prediction;
Secondary accessions: A4D116 A4D117 A8MXU2 O75241 Q2M377 Q75MF9 Q75MU7 Q86UI5 Q86UM9 Q9UQ29
Alternative splicing: 2 isoforms:  Q9Y6T7-1   Q9Y6T7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DGKB: NX_Q9Y6T7

Explore proteomics data for DGKB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y6T7

  • 4/18 DME Specific Peptides for DGKB (Q9Y6T7) (see all 18)
     FFRDVPD  LKFASQD  PEKFNSR  KSGGKQG 

    DGKB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DGKB Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_004071.1  NP_663733.1  

    ENSEMBL proteins: 
     ENSP00000385780   ENSP00000384909   ENSP00000385031   ENSP00000386066   ENSP00000405569  
     ENSP00000382260   ENSP00000258767   ENSP00000388451  
    Reactome Protein details: Q9Y6T7
    Human Recombinant Protein Products for DGKB: 
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    OriGene Protein Over-expression Lysate for DGKB
    OriGene MassSpec for DGKB 
    OriGene Custom Protein Services for DGKB
    GenScript Custom Purified and Recombinant Proteins Services for DGKB
    Novus Biologicals DGKB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--

    DGKB for ontologies           About GeneDecksing



    DGKB Antibody Products: 
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    Novus Biologicals DGKB Antibody
    Abcam antibodies for DGKB
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for DGKB
    LSBio Antibodies in human, mouse, rat for DGKB 

    Assay Products for DGKB: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing

    5/6 InterPro protein domains (see all 6):
     IPR001206 Diacylglycerol_kinase_cat_dom
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR000756 Diacylglycerol_kin_accessory
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q9Y6T7

    ProtoNet protein and cluster: Q9Y6T7

    1 Blocks protein domain: IPB000756 Diacylglycerol kinase accessory domain (presumed)

    UniProtKB/Swiss-Prot: DGKB_HUMAN, Q9Y6T7
    Similarity: Belongs to the eukaryotic diacylglycerol kinase family
    Similarity: Contains 1 DAGKc domain
    Similarity: Contains 2 EF-hand domains
    Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers


    DGKB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DGKB_HUMAN, Q9Y6T7
    Function: Exhibits high phosphorylation activity for long-chain diacylglycerols (By similarity)
    Catalytic activity: ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate
    Enzyme regulation: Stimulated by phosphatidylserine (By similarity)

         Genatlas biochemistry entry for DGKB:
    diacylglycerol kinase,beta,homolog to rat diacylglycerol

         Enzyme Numbers (IUBMB): EC 2.7.1.1071 2 EC 2.7.12

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003951NAD+ kinase activity IEA--
    GO:0004143diacylglycerol kinase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005524ATP binding IEA--
         
    DGKB for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DGKB:
     Decreased 12E8 tau but not tot  Increased apoptosis 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dgkb):
     behavior/neurological  homeostasis/metabolism  nervous system 

    DGKB for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DGKB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DGKB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DGKB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DGKB 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DGKB
    8/76 QIAGEN miScript miRNA Assays for microRNAs that regulate DGKB (see all 76):
    hsa-miR-124* hsa-miR-3678-3p hsa-miR-323-3p hsa-miR-607 hsa-miR-520f hsa-miR-4272 hsa-miR-605 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidDGKB 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DGKB
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of DGKB

    Clone
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    OriGene ORF clones in mouse, rat for DGKB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DGKB (NM_004080)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DGKB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DGKB
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                         Customized lentivirus expression plasmids for stable overexpression of DGKB 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGKB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DGKB About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    2G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    3Platelet activation, signaling and aggregation
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    4Glycerophospholipid biosynthesis
    Glycerophospholipid metabolism0.62
    5Inositol phosphate metabolism
    Phosphatidylinositol signaling system0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/8        Reactome Pathways for DGKB (see all 8)
        GPCR downstream signaling
    Hemostasis
    Effects of PIP2 hydrolysis
    Signal Transduction
    Gastrin-CREB signalling pathway via PKC and MAPK


    4         Kegg Pathways  (Kegg details for DGKB):
        Glycerolipid metabolism
    Glycerophospholipid metabolism
    Metabolic pathways
    Phosphatidylinositol signaling system


    DGKB for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DGKB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/39 Interacting proteins for DGKB (Q9Y6T73 ENSP000003822604) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRT31Q153233, ENSP000002516454I2D: score=2 STRING: ENSP00000251645
    PCDHB5Q9Y5E43, ENSP000002311344I2D: score=2 STRING: ENSP00000231134
    AGPAT2ENSP000003607614STRING: ENSP00000360761
    AGPAT4ENSP000003140364STRING: ENSP00000314036
    AGPAT3ENSP000002915724STRING: ENSP00000291572
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway IEA--
    GO:0007596blood coagulation TAS--
    GO:0030168platelet activation TAS--
    GO:0035556intracellular signal transduction IEA--

    DGKB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DGKB for compounds           About GeneDecksing

    EMD Millipore small molecules for DGKB:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for DGKB available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DioctanoylglycolDiacylglycerol kinase inhibitor[627-86-1]

    10/986 HMDB Compounds for DGKB (see all 986)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----

    10/11 Novoseek inferred chemical compound relationships for DGKB gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dioctanoylglycerol 64.1 1 15632189 (1)
    sphingosine 52.5 7 7548113 (2), 19066401 (1), 15381152 (1), 7548112 (1)
    phosphoinositide 49.1 4 16286473 (1), 10358932 (1), 18323690 (1)
    phosphatidylserine 46 2 15337525 (1)
    lipid 40.9 5 16286473 (1), 10913605 (1), 15381152 (1), 12015310 (1) (see all 5)
    12-o-tetradecanoylphorbol 13-acetate 31.9 1 15632189 (1)
    phosphatidylinositol 22.7 1 12494453 (1)
    atp 12.4 1 12441057 (1)
    calcium 2.23 4 9003401 (2), 15381152 (1), 12494453 (1)
    phospholipid 0 2 15337525 (1)

    Search CenterWatch for drugs/clinical trials and news about DGKB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DGKB gene (2 alternative transcripts): 
    NM_004080.2  NM_145695.2  

    Unigene Cluster for DGKB:

    Diacylglycerol kinase, beta 90kDa
    Hs.567255  [show with all ESTs]
    Unigene Representative Sequence: NM_004080
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000403951 ENST00000402815 ENST00000407950 ENST00000493142 ENST00000406247(uc003sta.3 uc011jxu.2)
    ENST00000403963(uc011jxv.1) ENST00000471732 ENST00000477401 ENST00000464065
    ENST00000467449 ENST00000437998 ENST00000463981 ENST00000399322(uc003ssz.3)
    ENST00000258767(uc011jxt.2) ENST00000444700
    miRNA
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    8/76 QIAGEN miScript miRNA Assays for microRNAs that regulate DGKB (see all 76):
    hsa-miR-124* hsa-miR-3678-3p hsa-miR-323-3p hsa-miR-607 hsa-miR-520f hsa-miR-4272 hsa-miR-605 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidDGKB 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DGKB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DGKB
    Sirion Biotech Customized lentivirus for stable overexpression of DGKB 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DGKB

    Additional mRNA sequence: 

    AB018261.1 AK124856.1 AK295668.1 AK304719.1 BC105005.1 BC143632.1 BC143633.1 

    5 DOTS entries:

    DT.92045520  DT.40263319  DT.102823920  DT.121121437  DT.95254099 

    14 AceView cDNA sequences:

    CA866268 AK124856 CA841291 CA841028 CA865978 AI863070 BG912323 BQ718321 
    BG201482 AB018261 NM_004080 BX951950 BX282157 BI032910 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DGKB expression in normal human tissues (normalized intensities)      DGKB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAAATATAA
    DGKB Expression
    About this image


    DGKB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
             caudate nucleus   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Peripheral Nervous System (Nervous System)
             PERIPHERAL NERVOUS SYSTEM   
     
     Gut Tube (Gastrointestinal Tract)
             Primitive gut tube-like cells ( A scalable, suspension protocol for derivation of...
     
     Lower Urinary Tract (Urinary System)
             visceral organ   

    See DGKB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DGKB

    SOURCE GeneReport for Unigene cluster: Hs.567255
        SABiosciences Custom PCR Arrays for DGKB
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DGKB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGKB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DGKB gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dgkb1 , 5 diacylglycerol kinase, beta1, 5 90.02(n)1
    96.73(a)1
      12 (17.11 cM)5
    2174801  NM_178681.41  NP_848796.21 
     378807055 
    chicken
    (Gallus gallus)
    Aves DGKB1 diacylglycerol kinase, beta 90kDa 83.29(n)
    90.87(a)
      772367  XM_001235515.2  XP_001235516.2 
    lizard
    (Anolis carolinensis)
    Reptilia DGKB6
    Uncharacterized protein
    88(a)
    1 ↔ 1
    6(26505266-26813639)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480471152   -- 78.06(n)    48047115 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.199752 Transcribed sequence with weak similarity to protein more 76.43(n)    CA472514.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dgk1 , 3 phosphatidylinositol biosynthesis
    diacylglycerol more3
    Diacyl glycerol kinase1
    57(a)3
    59.95(n)1
    61.17(a)1
      43E183
    357381  NM_001103749.21  NP_001097219.11 
    worm
    (Caenorhabditis elegans)
    Secernentea dgk-31 , 3 Diacylglycerol kinase3
    Protein DGK-31
    51(a)3
    58.29(n)1
    56.73(a)1
      III(9234802-9239752)3
    1862621  NM_066630.21  NP_499031.21 
    rice
    (Oryza sativa)
    Liliopsida Os.202012 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.63(n)    AK065676.1 


    ENSEMBL Gene Tree for DGKB (if available)
    TreeFam Gene Tree for DGKB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DGKB gene
    DGKH2  DGKQ2  DGKI2  DGKE2  DGKZ2  DGKA2  DGKG2  DGKD2  
    4 SIMAP similar genes for DGKB using alignment to 7 protein entries:     DGKB_HUMAN (see all proteins):
    DGKG    DAGK1    DGKA    DGKI

    DGKB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/16780 SNPs in DGKB are shown (see all 16780)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs351460731,2
    C--14133215(+) CTCTCA/GTGTTT 2 -- int10--------
    rs664681651,2
    C--14133227(+) GTGAT-/ATTTAC 2 -- int10--------
    rs1895320011,2
    --14133233(+) TTTACG/TCTCAT 2 -- int10--------
    rs358380951,2
    --14133237(+) CTCTCG/ATGTTT 2 -- int11Minor allele frequency- A:0.50NA 2
    rs348415151,2
    C--14133248(+) GTGAT-/A/TTTA
            
    TTTAC
    2 -- int10--------
    rs669228481,2
    C--14133249(+) TGATT-/ATTACT 2 -- int10--------
    rs1437998301,2
    --14133258(+) CTCTCA/GTGTTT 2 -- int10--------
    rs353492671,2
    C--14133270(+) GTGAT-/ATTTAC 2 -- int10--------
    rs624455691,2
    C,F--14133280(+) CTCTCG/ATGTTT 2 -- int12Minor allele frequency- A:0.50NA 4
    rs1818343051,2
    --14133282(+) CTCGTA/GTTTTG 2 -- int10--------

    HapMap Linkage Disequilibrium report for DGKB (14184674 - 14434674 bp, first 250kb of DGKB)

    Structural Variations
         Database of Genomic Variants (DGV) 10/56 variations for DGKB (see all 56):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734022CNV Deletion23290073
    esv3711CNV Deletion18987735
    esv2665678CNV Deletion23128226
    esv2734021CNV Deletion23290073
    esv2367407CNV Deletion18987734
    esv2734016CNV Deletion23290073
    esv2657075CNV Deletion23128226
    esv4153CNV Deletion18987735
    esv2589671CNV Deletion19546169
    esv2734018CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604070    OMIM disorders: --

    15 diseases for DGKB:    About MalaCards
    aggressive periodontitis    retinal degeneration    cerebral infarction    narcolepsy
    periodontitis    retinitis    cerebritis    retinoblastoma
    acute lymphoblastic leukemia    lymphoblastic leukemia    hypoxia    melanoma
    leukemia    breast cancer    neuronitis


    DGKB for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for DGKB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinal degeneration 28.8 2 15755798 (2)
    cancer 0 2 18062770 (1), 18691010 (1)

    Genetic Association Database (GAD): DGKB
    Human Genome Epidemiology (HuGE) Navigator: DGKB (18 documents)

    Export disorders for DGKB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DGKB gene, integrated from 9 sources (see all 118):
    (articles sorted by number of sources associating them with DGKB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evaluating the discriminative power of multi-trait ge netic risk scores for type 2 diabetes in a northern Swedish population. (PubMed id 20571754)1, 4 Fontaine-Bisson B....Franks P.W. (2010)
    2. Type 2 diabetes risk alleles near ADCY5, CDKAL1 and H HEX-IDE are associated with reduced birthweight. (PubMed id 20490451)1, 4 Andersson E.A....Pedersen O. (2010)
    3. New genetic loci implicated in fasting glucose homeos tasis and their impact on type 2 diabetes risk. (PubMed id 20081858)1, 4 Dupuis J....Zillikens M.C. (2010)
    4. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (2010)
    5. Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B lo ci are associated with reduced glucose-stimulated beta cell function in middle- aged Danish people. (PubMed id 20419449)1, 4 Boesgaard T.W....Borch-Johnsen K. (2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. (PubMed id 19176441)1, 4 Yang J.J....Relling M.V. (2009)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1607 HGNC: 2850 AceView: DGKB Ensembl:ENSG00000136267 euGenes: HUgn1607
    ECgene: DGKB Kegg: 1607 H-InvDB: DGKB

    (According to HUGE)
    About This Section
    HUGE: KIAA0718

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DGKB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DGKB gene:
    Search GeneIP for patents involving DGKB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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