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Aliases for DGKB Gene

Aliases for DGKB Gene

  • Diacylglycerol Kinase Beta 2 3 5
  • Diacylglycerol Kinase, Beta 90kDa 2 3
  • 90 KDa Diacylglycerol Kinase 3 4
  • Diglyceride Kinase Beta 3 4
  • DAG Kinase Beta 3 4
  • EC 2.7.1.107 4 61
  • DGK-BETA 3 4
  • DAGK2 3 4
  • Diacylglycerol Kinase, Beta (90kD) 2
  • KIAA0718 4
  • EC 2.7.1 61
  • DGK 3

External Ids for DGKB Gene

Previous HGNC Symbols for DGKB Gene

  • DAGK2

Previous GeneCards Identifiers for DGKB Gene

  • GC07M013831
  • GC07M013931
  • GC07M013960
  • GC07M014153
  • GC07M014066

Summaries for DGKB Gene

Entrez Gene Summary for DGKB Gene

  • Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DGKB Gene

DGKB (Diacylglycerol Kinase Beta) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Effects of PIP2 hydrolysis. GO annotations related to this gene include calcium ion binding and diacylglycerol kinase activity. An important paralog of this gene is DGKG.

UniProtKB/Swiss-Prot for DGKB Gene

  • Exhibits high phosphorylation activity for long-chain diacylglycerols.

Tocris Summary for DGKB Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.

Gene Wiki entry for DGKB Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGKB Gene

Genomics for DGKB Gene

Regulatory Elements for DGKB Gene

Enhancers for DGKB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F014834 0.9 FANTOM5 Ensembl ENCODE 39.3 +139.0 139007 3.1 PKNOX1 MAX SIN3A ZIC2 RAD21 HIC1 FOS ZNF600 MAFK TCF7L2 DGKB LOC105375163 GC07M014874
GH07F014747 0.8 Ensembl ENCODE 6.4 +226.4 226377 1.6 JUND JUN RAD21 TCF7L2 DGKB LOC105375163 GC07P014687
GH07F014760 0.9 Ensembl ENCODE 5.6 +212.9 212857 2.0 JUND SIN3A DGKB LOC105375163 GC07P014687
GH07F014903 0.2 ENCODE 5.5 +71.2 71217 0.2 SMARCA4 POLR2A TEAD4 WT1 TRIM28 DGKB GC07M014874
GH07F014734 0.2 Ensembl 5.4 +239.7 239668 0.7 CTCF DGKB GC07P014687 LOC105375163
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DGKB on UCSC Golden Path with GeneCards custom track

Genomic Location for DGKB Gene

Chromosome:
7
Start:
14,145,049 bp from pter
End:
14,974,777 bp from pter
Size:
829,729 bases
Orientation:
Minus strand

Genomic View for DGKB Gene

Genes around DGKB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGKB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGKB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKB Gene

Proteins for DGKB Gene

  • Protein details for DGKB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6T7-DGKB_HUMAN
    Recommended name:
    Diacylglycerol kinase beta
    Protein Accession:
    Q9Y6T7
    Secondary Accessions:
    • A4D116
    • A4D117
    • A8MXU2
    • O75241
    • Q2M377
    • Q75MF9
    • Q75MU7
    • Q86UI5
    • Q86UM9
    • Q9UQ29

    Protein attributes for DGKB Gene

    Size:
    804 amino acids
    Molecular mass:
    90595 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAS07533.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for DGKB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DGKB Gene

Post-translational modifications for DGKB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for DGKB Gene

Suggested Antigen Peptide Sequences for DGKB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6T7

UniProtKB/Swiss-Prot:

DGKB_HUMAN :
  • Contains 1 DAGKc domain.
  • Belongs to the eukaryotic diacylglycerol kinase family.
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
Domain:
  • Contains 1 DAGKc domain.
  • Contains 2 EF-hand domains.
Family:
  • Belongs to the eukaryotic diacylglycerol kinase family.
Similarity:
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
genes like me logo Genes that share domains with DGKB: view

Function for DGKB Gene

Molecular function for DGKB Gene

GENATLAS Biochemistry:
diacylglycerol kinase,beta,homolog to rat diacylglycerol
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated by phosphatidylserine.
UniProtKB/Swiss-Prot Function:
Exhibits high phosphorylation activity for long-chain diacylglycerols.

Enzyme Numbers (IUBMB) for DGKB Gene

Gene Ontology (GO) - Molecular Function for DGKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004143 diacylglycerol kinase activity TAS --
GO:0005509 calcium ion binding IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with DGKB: view
genes like me logo Genes that share phenotypes with DGKB: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DGKB

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DGKB Gene

Localization for DGKB Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGKB Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DGKB Gene COMPARTMENTS Subcellular localization image for DGKB gene
Compartment Confidence
plasma membrane 5
cytosol 3
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for DGKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with DGKB: view

Pathways & Interactions for DGKB Gene

genes like me logo Genes that share pathways with DGKB: view

Gene Ontology (GO) - Biological Process for DGKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0016310 phosphorylation IEA --
GO:0030168 platelet activation TAS --
GO:0035556 intracellular signal transduction IEA --
GO:0046486 glycerolipid metabolic process IDA 22627129
genes like me logo Genes that share ontologies with DGKB: view

No data available for SIGNOR curated interactions for DGKB Gene

Drugs & Compounds for DGKB Gene

(8) Drugs for DGKB Gene - From: ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Dioctanoylglycol Pharma Diacylglycerol kinase inhibitor 0
R 59-022 Pharma Diacylglycerol kinase inhibitor; increases PKC activity 0

(152) Additional Compounds for DGKB Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(2) Tocris Compounds for DGKB Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor 627-86-1
R 59-022 Diacylglycerol kinase inhibitor; increases PKC activity 93076-89-2

(1) ApexBio Compounds for DGKB Gene

Compound Action Cas Number
Dioctanoylglycol 627-86-1
genes like me logo Genes that share compounds with DGKB: view

Transcripts for DGKB Gene

Unigene Clusters for DGKB Gene

Diacylglycerol kinase, beta 90kDa:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DGKB Gene

No ASD Table

Relevant External Links for DGKB Gene

GeneLoc Exon Structure for
DGKB
ECgene alternative splicing isoforms for
DGKB

Expression for DGKB Gene

mRNA expression in normal human tissues for DGKB Gene

mRNA differential expression in normal tissues according to GTEx for DGKB Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x10.0), Brain - Caudate (basal ganglia) (x9.3), Brain - Nucleus accumbens (basal ganglia) (x8.3), Brain - Anterior cingulate cortex (BA24) (x4.4), and Brain - Frontal Cortex (BA9) (x4.4).

Protein differential expression in normal tissues from HIPED for DGKB Gene

This gene is overexpressed in Lymph node (32.0) and CD4 Tcells (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DGKB Gene



NURSA nuclear receptor signaling pathways regulating expression of DGKB Gene:

DGKB

SOURCE GeneReport for Unigene cluster for DGKB Gene:

Hs.567255
genes like me logo Genes that share expression patterns with DGKB: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for DGKB Gene

Orthologs for DGKB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DGKB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DGKB 34 35
  • 99.67 (n)
dog
(Canis familiaris)
Mammalia DGKB 34 35
  • 94.56 (n)
cow
(Bos Taurus)
Mammalia DGKB 34 35
  • 94.02 (n)
oppossum
(Monodelphis domestica)
Mammalia DGKB 35
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dgkb 34
  • 90.18 (n)
mouse
(Mus musculus)
Mammalia Dgkb 34 16 35
  • 90.02 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 89 (a)
OneToMany
-- 35
  • 86 (a)
OneToMany
chicken
(Gallus gallus)
Aves DGKB 34 35
  • 83 (n)
lizard
(Anolis carolinensis)
Reptilia DGKB 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dgkb 34
  • 76.65 (n)
zebrafish
(Danio rerio)
Actinopterygii dgkb 34 35
  • 68.97 (n)
Dr.19975 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006762 34
  • 59.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dgk 36 34 35
  • 58.44 (n)
worm
(Caenorhabditis elegans)
Secernentea dgk-3 36 34 35
  • 58.04 (n)
rice
(Oryza sativa)
Liliopsida Os.20201 34
corn
(Zea mays)
Liliopsida Zm.4984 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10986 35
  • 55 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12076 34
Species where no ortholog for DGKB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DGKB Gene

ENSEMBL:
Gene Tree for DGKB (if available)
TreeFam:
Gene Tree for DGKB (if available)

Paralogs for DGKB Gene

Paralogs for DGKB Gene

(6) SIMAP similar genes for DGKB Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with DGKB: view

Variants for DGKB Gene

Sequence variations from dbSNP and Humsavar for DGKB Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10046466 -- 14,367,673(+) gaaat(A/G)cccaa intron-variant
rs10046589 -- 14,909,286(+) ATTTT(A/G)AAATG intron-variant
rs10081218 -- 14,760,345(+) AATAG(A/C)ATTGC intron-variant
rs10085416 -- 14,829,188(+) AAGGC(A/G)CCCCA intron-variant
rs10085417 -- 14,829,329(+) ATAAT(C/T)AGATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DGKB Gene

Variant ID Type Subtype PubMed ID
dgv3496n106 CNV deletion 24896259
dgv3497n106 CNV deletion 24896259
dgv3498n106 CNV deletion 24896259
dgv3746e59 CNV duplication 20981092
dgv422e215 CNV deletion 23714750
esv1008785 CNV deletion 20482838
esv1008799 CNV deletion 20482838
esv1248437 CNV insertion 17803354
esv1543610 CNV deletion 17803354
esv1572679 CNV deletion 17803354
esv1770636 CNV deletion 17803354
esv2009841 CNV deletion 18987734
esv2035361 CNV deletion 18987734
esv2144200 CNV deletion 18987734
esv22096 CNV loss 19812545
esv2227136 CNV deletion 18987734
esv2367407 CNV deletion 18987734
esv2372428 CNV deletion 18987734
esv2516570 CNV insertion 19546169
esv2589671 CNV deletion 19546169
esv2590385 CNV deletion 19546169
esv2609849 CNV insertion 19546169
esv2648403 CNV deletion 19546169
esv26569 CNV loss 19812545
esv2657075 CNV deletion 23128226
esv2665678 CNV deletion 23128226
esv2673931 CNV deletion 23128226
esv2676590 CNV deletion 23128226
esv2734011 CNV deletion 23290073
esv2734012 CNV deletion 23290073
esv2734013 CNV deletion 23290073
esv2734014 CNV deletion 23290073
esv2734015 CNV deletion 23290073
esv2734016 CNV deletion 23290073
esv2734018 CNV deletion 23290073
esv2734019 CNV deletion 23290073
esv2734020 CNV deletion 23290073
esv2734021 CNV deletion 23290073
esv2734022 CNV deletion 23290073
esv2734023 CNV deletion 23290073
esv2734024 CNV deletion 23290073
esv27782 CNV gain+loss 19812545
esv3304669 CNV mobile element insertion 20981092
esv3310074 CNV mobile element insertion 20981092
esv3361892 CNV insertion 20981092
esv3373354 CNV insertion 20981092
esv3385896 CNV insertion 20981092
esv3393920 CNV insertion 20981092
esv3432121 CNV insertion 20981092
esv3541223 CNV deletion 23714750
esv3541224 CNV deletion 23714750
esv3541229 CNV deletion 23714750
esv3541230 CNV deletion 23714750
esv3571661 CNV loss 25503493
esv3571662 CNV loss 25503493
esv3612306 CNV gain 21293372
esv3612310 CNV gain 21293372
esv3612311 CNV loss 21293372
esv3612313 CNV gain 21293372
esv3612316 CNV gain 21293372
esv3612319 CNV loss 21293372
esv3612320 CNV gain 21293372
esv3612322 CNV gain 21293372
esv3711 CNV loss 18987735
esv3891062 CNV gain+loss 25118596
esv3891064 CNV gain 25118596
esv4153 CNV loss 18987735
esv7200 CNV loss 19470904
nsv1015581 CNV loss 25217958
nsv1015777 CNV loss 25217958
nsv1020722 CNV loss 25217958
nsv1021056 CNV gain 25217958
nsv1022267 CNV loss 25217958
nsv1023616 CNV gain 25217958
nsv1024192 CNV loss 25217958
nsv1025437 CNV loss 25217958
nsv1033406 CNV loss 25217958
nsv1073702 CNV deletion 25765185
nsv1074074 CNV deletion 25765185
nsv1074646 CNV deletion 25765185
nsv1075011 CNV deletion 25765185
nsv1076869 CNV deletion 25765185
nsv1109444 CNV deletion 24896259
nsv1114918 CNV deletion 24896259
nsv1124175 CNV deletion 24896259
nsv1137193 CNV deletion 24896259
nsv1146427 CNV deletion 26484159
nsv1147057 CNV deletion 26484159
nsv1150451 CNV deletion 26484159
nsv478237 CNV novel sequence insertion 20440878
nsv511949 CNV loss 21212237
nsv518783 CNV loss 19592680
nsv606280 CNV loss 21841781
nsv606281 CNV loss 21841781
nsv606282 CNV loss 21841781
nsv606283 CNV gain 21841781
nsv606284 CNV gain 21841781
nsv8052 CNV loss 18304495
nsv8053 CNV gain+loss 18304495
nsv8054 CNV gain 18304495
nsv821255 CNV deletion 20802225
nsv821652 CNV loss 15273396
nsv956009 CNV deletion 24416366
nsv957581 CNV deletion 24416366
nsv970798 CNV duplication 23825009

Variation tolerance for DGKB Gene

Residual Variation Intolerance Score: 10.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.05; 60.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DGKB Gene

Human Gene Mutation Database (HGMD)
DGKB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DGKB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGKB Gene

Disorders for DGKB Gene

Relevant External Links for DGKB

Genetic Association Database (GAD)
DGKB
Human Genome Epidemiology (HuGE) Navigator
DGKB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DGKB

No disorders were found for DGKB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DGKB Gene

Publications for DGKB Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people. (PMID: 20419449) Boesgaard T.W. … Pedersen O. (Diabetologia 2010) 3 46 64
  3. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PMID: 20571754) Fontaine-Bisson B. … Franks P.W. (Diabetologia 2010) 3 46 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 46 64

Products for DGKB Gene

Sources for DGKB Gene