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Aliases for DGKA Gene

Aliases for DGKA Gene

  • Diacylglycerol Kinase, Alpha 80kDa 2 3
  • DAGK1 3 4 6
  • 80 KDa Diacylglycerol Kinase 3 4
  • Diglyceride Kinase Alpha 3 4
  • DAG Kinase Alpha 3 4
  • EC 2.7.1.107 4 64
  • DGK-Alpha 3 4
  • DAGK 3 4
  • Diacylglycerol Kinase, Alpha (80kD) 2
  • Diacylglycerol Kinase Alpha 3

External Ids for DGKA Gene

Previous Symbols for DGKA Gene

  • DAGK
  • DAGK1

Summaries for DGKA Gene

Entrez Gene Summary for DGKA Gene

  • The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for DGKA Gene

DGKA (Diacylglycerol Kinase, Alpha 80kDa) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include calcium ion binding and NAD+ kinase activity. An important paralog of this gene is DGKI.

UniProtKB/Swiss-Prot for DGKA Gene

  • Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity

Tocris Summary for DGKA Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes (DGKalpha, DGKbeta, DGKgamma, DGKdelta, DGKepsilon, DGKzeta, DGKeta, DGKtheta, DGKiota and DGKkappa) that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C-terminal catalytic domain, two cysteine-rich Zn2+-finger motifs that bind DAG and an ATP-binding site, whilst the regulatory domain varies. DGKs are widely distributed throughout mammalian tissues and different isozymes have different subcellular localizations; some are cytosolic (for example DGKalpha), some are membrane-bound (for example DGKgamma is associated with the Golgi membrane) and some are nuclear (for example DGKzeta. DGKs have diverse biological roles as they participate in signal transduction by modulating levels of DAG in a variety of cellular responses to extracellular stimuli.

Gene Wiki entry for DGKA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGKA Gene

Genomics for DGKA Gene

Genomic Location for DGKA Gene

Start:
55,927,319 bp from pter
End:
55,954,027 bp from pter
Size:
26,709 bases
Orientation:
Plus strand

Genomic View for DGKA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DGKA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKA Gene

Regulatory Elements for DGKA Gene

Proteins for DGKA Gene

  • Protein details for DGKA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23743-DGKA_HUMAN
    Recommended name:
    Diacylglycerol kinase alpha
    Protein Accession:
    P23743
    Secondary Accessions:
    • O75481
    • O75482
    • O75483
    • O95217
    • Q3ZE25
    • Q8IZ56
    • Q8N5Q2

    Protein attributes for DGKA Gene

    Size:
    735 amino acids
    Molecular mass:
    82630 Da
    Quaternary structure:
    • Monomer

    Three dimensional structures from OCA and Proteopedia for DGKA Gene

    Alternative splice isoforms for DGKA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DGKA Gene

Proteomics data for DGKA Gene at MOPED

Post-translational modifications for DGKA Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys18, Lys239, Lys249, Lys263, Lys353, Lys411, Lys484, Lys493, and Lys634

Domains for DGKA Gene

Gene Families for DGKA Gene

HGNC:
  • EFHAND :EF-hand domain containing

UniProtKB/Swiss-Prot:

DGKA_HUMAN
Domain:
  • Contains 1 DAGKc domain.:
    • P23743
  • Contains 2 EF-hand domains.:
    • P23743
Family:
  • Belongs to the eukaryotic diacylglycerol kinase family.:
    • P23743
Similarity:
  • Contains 2 phorbol-ester/DAG-type zinc fingers.:
    • P23743
genes like me logo Genes that share domains with DGKA: view

Function for DGKA Gene

Molecular function for DGKA Gene

GENATLAS Biochemistry: diacylglycerol kinase,86kDa,putative modulator of protein kinase C,in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity: ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Stimulated by calcium and phosphatidylserine. Phosphorylated by protein kinase C
UniProtKB/Swiss-Prot Function: Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity

Enzyme Numbers (IUBMB) for DGKA Gene

Gene Ontology (GO) - Molecular Function for DGKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003951 NAD+ kinase activity IEA --
GO:0004143 diacylglycerol kinase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005524 ATP binding IEA --
GO:0005543 phospholipid binding IEA --
genes like me logo Genes that share ontologies with DGKA: view

Phenotypes for DGKA Gene

genes like me logo Genes that share phenotypes with DGKA: view

Animal Models for DGKA Gene

MGI Knock Outs for DGKA:

miRNA for DGKA Gene

miRTarBase miRNAs that target DGKA

No data available for Transcription Factor Targeting and HOMER Transcription for DGKA Gene

Localization for DGKA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DGKA Gene COMPARTMENTS Subcellular localization image for DGKA gene
Compartment Confidence
plasma membrane 4
cytosol 3
nucleus 1

Gene Ontology (GO) - Cellular Components for DGKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DGKA: view

Pathways for DGKA Gene

genes like me logo Genes that share pathways with DGKA: view

Gene Ontology (GO) - Biological Process for DGKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0007596 blood coagulation TAS --
GO:0016310 phosphorylation IEA --
GO:0030168 platelet activation TAS --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with DGKA: view

Compounds for DGKA Gene

(1) Tocris Compounds for DGKA Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor [627-86-1]

(987) HMDB Compounds for DGKA Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Calcium
  • Ca
7440-70-2
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available

(1) Drugbank Compounds for DGKA Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Vitamin E
  • alpha-Tocopherol
59-02-9 target

(4) Novoseek inferred chemical compound relationships for DGKA Gene

Compound -log(P) Hits PubMed IDs
tyrosine 44.8 7
phosphoinositide 29.6 1
lipid 17.3 4
calcium 0 1
genes like me logo Genes that share compounds with DGKA: view

Transcripts for DGKA Gene

Unigene Clusters for DGKA Gene

Diacylglycerol kinase, alpha 80kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DGKA Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15a ·
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - -
SP5:
SP6: - - - - - - - - - -
SP7: - -
SP8: - - - - - - -
SP9: - - - - -
SP10: - - - - -
SP11: - -
SP12:
SP13: - - - -
SP14: - - - - -
SP15: - - - -
SP16:
SP17:
SP18:

ExUns: 15b ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - -
SP5: - -
SP6:
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17: -
SP18:

Relevant External Links for DGKA Gene

GeneLoc Exon Structure for
DGKA
ECgene alternative splicing isoforms for
DGKA

Expression for DGKA Gene

mRNA expression in normal human tissues for DGKA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DGKA Gene

This gene is overexpressed in Whole Blood (5.1) and Esophagus - Mucosa (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DGKA Gene

SOURCE GeneReport for Unigene cluster for DGKA Gene Hs.524488

mRNA Expression by UniProt/SwissProt for DGKA Gene

P23743-DGKA_HUMAN
Tissue specificity: Lymphocytes and oligodendroglial cells
genes like me logo Genes that share expressions with DGKA: view

Orthologs for DGKA Gene

This gene was present in the common ancestor of animals.

Orthologs for DGKA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DGKA 36
  • 99.64 (n)
  • 100 (a)
DGKA 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DGKA 36
  • 92.04 (n)
  • 93.45 (a)
DGKA 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DGKA 36
  • 91.5 (n)
  • 93.32 (a)
DGKA 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dgka 36
  • 83.45 (n)
  • 82.99 (a)
Dgka 16
Dgka 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 59 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia DGKA 37
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dgka 36
  • 83.43 (n)
  • 83.75 (a)
lizard
(Anolis carolinensis)
Reptilia DGKA 37
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dgka 36
  • 64.79 (n)
  • 66.44 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6786 36
zebrafish
(Danio rerio)
Actinopterygii DGKA (1 of 2) 37
  • 50 (a)
OneToMany
dgkaa 36
  • 64.6 (n)
  • 63.57 (a)
dgkaa 37
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Dgk 37
  • 30 (a)
OneToMany
Dgk 38
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea dgk-3 37
  • 44 (a)
OneToMany
dgk-3 38
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10986 37
  • 44 (a)
OneToMany
Species with no ortholog for DGKA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DGKA Gene

ENSEMBL:
Gene Tree for DGKA (if available)
TreeFam:
Gene Tree for DGKA (if available)

Paralogs for DGKA Gene

Paralogs for DGKA Gene

genes like me logo Genes that share paralogs with DGKA: view

Variants for DGKA Gene

Sequence variations from dbSNP and Humsavar for DGKA Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs772697 -- 55,932,416(+) CCTCT(A/T)CGGAA intron-variant
rs772698 -- 55,932,309(+) GGGCC(A/C)GAACC intron-variant
rs772699 -- 55,932,282(-) CCCCG(C/T)GTCCC intron-variant
rs772700 -- 55,931,635(+) TTGGT(C/T)AGGGA intron-variant, upstream-variant-2KB
rs772701 -- 55,931,222(-) GGATG(C/G)TGGTG utr-variant-5-prime, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DGKA Gene

Variant ID Type Subtype PubMed ID
nsv832424 CNV Loss 17160897

Relevant External Links for DGKA Gene

HapMap Linkage Disequilibrium report
DGKA

Disorders for DGKA Gene

No disorders were found for DGKA Gene.

No data available for UniProtKB/Swiss-Prot for DGKA Gene

Publications for DGKA Gene

  1. Assignment of the human diacylglycerol kinase gene (DAGK) to 12q13.3 using fluorescence in situ hybridization analysis. (PMID: 7959783) Hart T.C. … Pettenati M.J. (Genomics 1994) 2 3 4
  2. Assignment of the gene for diacylglycerol kinase (DAGK) to human chromosome 12. (PMID: 8180475) Hart T.C. … van Dyke T.E. (Mamm. Genome 1994) 2 3 4
  3. Activation of diacylglycerol kinase alpha is required for VEGF-induced angiogenic signaling in vitro. (PMID: 15122338) Baldanzi G. … Graziani A. (Oncogene 2004) 3 23
  4. Diacylglycerol kinase alpha suppresses tumor necrosis factor-alpha-induced apoptosis of human melanoma cells through NF-kappaB activation. (PMID: 17276726) Yanagisawa K. … Sakane F. (Biochim. Biophys. Acta 2007) 3 23
  5. Diacylglycerol kinase-alpha mediates hepatocyte growth factor-induced epithelial cell scatter by regulating Rac activation and membrane ruffling. (PMID: 17898083) Chianale F. … Graziani A. (Mol. Biol. Cell 2007) 3 23

Products for DGKA Gene

  • Addgene plasmids for DGKA

Sources for DGKA Gene

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