Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DGKA Gene

Aliases for DGKA Gene

  • Diacylglycerol Kinase Alpha 2 3 5
  • Diacylglycerol Kinase, Alpha 80kDa 2 3
  • 80 KDa Diacylglycerol Kinase 3 4
  • Diglyceride Kinase Alpha 3 4
  • DAG Kinase Alpha 3 4
  • EC 2.7.1.107 4 63
  • DGK-Alpha 3 4
  • DAGK1 3 4
  • DAGK 3 4
  • Diacylglycerol Kinase, Alpha (80kD) 2

External Ids for DGKA Gene

Previous HGNC Symbols for DGKA Gene

  • DAGK
  • DAGK1

Previous GeneCards Identifiers for DGKA Gene

  • GC12M056229
  • GC12U900027
  • GC12P056042
  • GC12P054611
  • GC12P056324
  • GC12P053363

Summaries for DGKA Gene

Entrez Gene Summary for DGKA Gene

  • The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for DGKA Gene

DGKA (Diacylglycerol Kinase Alpha) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include calcium ion binding and NAD+ kinase activity. An important paralog of this gene is DGKI.

UniProtKB/Swiss-Prot for DGKA Gene

  • Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity.

Tocris Summary for DGKA Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.

Gene Wiki entry for DGKA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGKA Gene

Genomics for DGKA Gene

Regulatory Elements for DGKA Gene

Promoters for DGKA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DGKA on UCSC Golden Path with GeneCards custom track

Genomic Location for DGKA Gene

Chromosome:
12
Start:
55,927,319 bp from pter
End:
55,954,027 bp from pter
Size:
26,709 bases
Orientation:
Plus strand

Genomic View for DGKA Gene

Genes around DGKA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGKA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGKA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKA Gene

Proteins for DGKA Gene

  • Protein details for DGKA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23743-DGKA_HUMAN
    Recommended name:
    Diacylglycerol kinase alpha
    Protein Accession:
    P23743
    Secondary Accessions:
    • O75481
    • O75482
    • O75483
    • O95217
    • Q3ZE25
    • Q8IZ56
    • Q8N5Q2

    Protein attributes for DGKA Gene

    Size:
    735 amino acids
    Molecular mass:
    82630 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for DGKA Gene

    Alternative splice isoforms for DGKA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DGKA Gene

Proteomics data for DGKA Gene at MOPED

Post-translational modifications for DGKA Gene

  • Ubiquitination at Lys 18, Lys 239, Lys 249, Lys 263, Lys 353, Lys 411, Lys 484, Lys 493, and Lys 634
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for DGKA Gene

Suggested Antigen Peptide Sequences for DGKA Gene

Graphical View of Domain Structure for InterPro Entry

P23743

UniProtKB/Swiss-Prot:

DGKA_HUMAN :
  • Contains 1 DAGKc domain.
  • Belongs to the eukaryotic diacylglycerol kinase family.
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
Domain:
  • Contains 1 DAGKc domain.
  • Contains 2 EF-hand domains.
Family:
  • Belongs to the eukaryotic diacylglycerol kinase family.
Similarity:
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
genes like me logo Genes that share domains with DGKA: view

Function for DGKA Gene

Molecular function for DGKA Gene

GENATLAS Biochemistry:
diacylglycerol kinase,86kDa,putative modulator of protein kinase C,in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated by calcium and phosphatidylserine. Phosphorylated by protein kinase C.
UniProtKB/Swiss-Prot Function:
Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity.

Enzyme Numbers (IUBMB) for DGKA Gene

Gene Ontology (GO) - Molecular Function for DGKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DGKA: view
genes like me logo Genes that share phenotypes with DGKA: view

Animal Models for DGKA Gene

MGI Knock Outs for DGKA:

Animal Model Products

miRNA for DGKA Gene

miRTarBase miRNAs that target DGKA

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DGKA Gene

Localization for DGKA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DGKA Gene COMPARTMENTS Subcellular localization image for DGKA gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for DGKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with DGKA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DGKA Gene

Pathways & Interactions for DGKA Gene

genes like me logo Genes that share pathways with DGKA: view

SIGNOR curated interactions for DGKA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DGKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with DGKA: view

Drugs & Compounds for DGKA Gene

(4) Drugs for DGKA Gene - From: HMDB, DrugBank, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin E Approved Nutra Target 371,376
Adenosine triphosphate Approved Nutra 0
calcium Nutra 0

(150) Additional Compounds for DGKA Gene - From: HMDB, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with DGKA: view

Transcripts for DGKA Gene

Unigene Clusters for DGKA Gene

Diacylglycerol kinase, alpha 80kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DGKA Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15a ·
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - -
SP5:
SP6: - - - - - - - - - -
SP7: - -
SP8: - - - - - - -
SP9: - - - - -
SP10: - - - - -
SP11: - -
SP12:
SP13: - - - -
SP14: - - - - -
SP15: - - - -
SP16:
SP17:
SP18:

ExUns: 15b ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - -
SP5: - -
SP6:
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17: -
SP18:

Relevant External Links for DGKA Gene

GeneLoc Exon Structure for
DGKA
ECgene alternative splicing isoforms for
DGKA

Expression for DGKA Gene

mRNA expression in normal human tissues for DGKA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DGKA Gene

This gene is overexpressed in Whole Blood (x5.1) and Esophagus - Mucosa (x4.9).

Protein differential expression in normal tissues from HIPED for DGKA Gene

This gene is overexpressed in Lymph node (24.5), Peripheral blood mononuclear cells (11.7), Tlymphocyte (11.0), and CD4 Tcells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DGKA Gene



SOURCE GeneReport for Unigene cluster for DGKA Gene Hs.524488

mRNA Expression by UniProt/SwissProt for DGKA Gene

P23743-DGKA_HUMAN
Tissue specificity: Lymphocytes and oligodendroglial cells.
genes like me logo Genes that share expression patterns with DGKA: view

Protein tissue co-expression partners for DGKA Gene

- Elite partner

In Situ Assay Products

Orthologs for DGKA Gene

This gene was present in the common ancestor of animals.

Orthologs for DGKA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DGKA 35
  • 99.64 (n)
  • 100 (a)
DGKA 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DGKA 35
  • 92.04 (n)
  • 93.45 (a)
DGKA 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DGKA 36
  • 93 (a)
OneToOne
DGKA 35
  • 91.5 (n)
  • 93.32 (a)
mouse
(Mus musculus)
Mammalia Dgka 16
Dgka 35
  • 83.45 (n)
  • 82.99 (a)
Dgka 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 59 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia DGKA 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dgka 35
  • 83.43 (n)
  • 83.75 (a)
lizard
(Anolis carolinensis)
Reptilia DGKA 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dgka 35
  • 64.79 (n)
  • 66.44 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6786 35
zebrafish
(Danio rerio)
Actinopterygii DGKA (1 of 2) 36
  • 50 (a)
OneToMany
dgkaa 36
  • 61 (a)
OneToMany
dgkaa 35
  • 64.6 (n)
  • 63.57 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dgk 36
  • 30 (a)
OneToMany
Dgk 37
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea dgk-3 36
  • 44 (a)
OneToMany
dgk-3 37
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10986 36
  • 44 (a)
OneToMany
Species with no ortholog for DGKA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DGKA Gene

ENSEMBL:
Gene Tree for DGKA (if available)
TreeFam:
Gene Tree for DGKA (if available)

Paralogs for DGKA Gene

Paralogs for DGKA Gene

genes like me logo Genes that share paralogs with DGKA: view

Variants for DGKA Gene

Sequence variations from dbSNP and Humsavar for DGKA Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs17852990 - 55,952,059(+) GATTC(C/T)ACATC intron-variant, reference, missense
rs772700 -- 55,931,635(+) TTGGT(C/T)AGGGA intron-variant, upstream-variant-2KB
rs772701 -- 55,931,222(-) GGATG(C/G)TGGTG upstream-variant-2KB, utr-variant-5-prime
rs1395282 -- 55,953,101(-) GTATA(A/G)ATTTG nc-transcript-variant, reference, synonymous-codon
rs1483004 -- 55,930,929(-) GGTGG(G/T)GGTTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DGKA Gene

Variant ID Type Subtype PubMed ID
nsv832424 CNV Loss 17160897

Variation tolerance for DGKA Gene

Residual Variation Intolerance Score: 10.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DGKA Gene

HapMap Linkage Disequilibrium report
DGKA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGKA Gene

Disorders for DGKA Gene

Relevant External Links for DGKA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DGKA

No disorders were found for DGKA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DGKA Gene

Publications for DGKA Gene

  1. Assignment of the gene for diacylglycerol kinase (DAGK) to human chromosome 12. (PMID: 8180475) Hart T.C. … van Dyke T.E. (Mamm. Genome 1994) 2 3 4 67
  2. Diacylglycerol kinase alpha mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI. (PMID: 20160093) Chianale F. … Graziani A. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 23
  3. Diacylglycerol kinase alpha enhances protein kinase Czeta-dependent phosphorylation at Ser311 of p65/RelA subunit of nuclear factor-kappaB. (PMID: 19751727) Kai M. … Sakane F. (FEBS Lett. 2009) 3 23
  4. Lck-dependent tyrosine phosphorylation of diacylglycerol kinase alpha regulates its membrane association in T cells. (PMID: 18424699) Merino E. … MAcrida I. (J. Immunol. 2008) 3 23
  5. Diacylglycerol kinase-alpha phosphorylation by Src on Y335 is required for activation, membrane recruitment and Hgf-induced cell motility. (PMID: 17700527) Baldanzi G. … Graziani A. (Oncogene 2008) 3 23

Products for DGKA Gene

Sources for DGKA Gene

Back to Top

Content