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Aliases for DGKA Gene

Aliases for DGKA Gene

  • Diacylglycerol Kinase Alpha 2 3 5
  • Diacylglycerol Kinase, Alpha 80kDa 2 3
  • 80 KDa Diacylglycerol Kinase 3 4
  • Diglyceride Kinase Alpha 3 4
  • DAG Kinase Alpha 3 4
  • EC 2.7.1.107 4 58
  • DGK-Alpha 3 4
  • DAGK1 3 4
  • DAGK 3 4
  • Diacylglycerol Kinase, Alpha (80kD) 2

External Ids for DGKA Gene

Previous HGNC Symbols for DGKA Gene

  • DAGK
  • DAGK1

Previous GeneCards Identifiers for DGKA Gene

  • GC12M056229
  • GC12U900027
  • GC12P056042
  • GC12P054611
  • GC12P056324
  • GC12P053363

Summaries for DGKA Gene

Entrez Gene Summary for DGKA Gene

  • The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Several transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Apr 2017]

GeneCards Summary for DGKA Gene

DGKA (Diacylglycerol Kinase Alpha) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Inositol phosphate metabolism (KEGG). GO annotations related to this gene include calcium ion binding and NAD+ kinase activity. An important paralog of this gene is DGKB.

UniProtKB/Swiss-Prot for DGKA Gene

  • Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity.

Tocris Summary for DGKA Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.

Gene Wiki entry for DGKA Gene

Additional gene information for DGKA Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGKA Gene

Genomics for DGKA Gene

Regulatory Elements for DGKA Gene

Enhancers for DGKA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H055925 2 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +6.0 6020 16 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 YBX1 ZNF2 ZBTB7B BAZ2A DNAJC14 PYM1 RN7SL809P ZC3H10 TMEM198B RNU6-343P PRIM1 CDK2 RDH5
GH12H055955 1.4 Ensembl ENCODE dbSUPER 12.9 +29.7 29703 3 PKNOX1 NFIB SIN3A RAD21 ZEB1 RFX5 GLIS2 FOS RCOR1 DEK DGKA RPS26 SARNP ORMDL2 MMP19 RDH5 MYL6B CDK2 PYM1
GH12H055908 1.3 Ensembl ENCODE dbSUPER 0.4 -17.9 -17910 1 SOX13 TFAP4 ARNT YBX1 THRB ZNF7 TEAD3 GATA3 LCORL NCOR1 PYM1 GSTP1P1 DGKA
GH12H055919 0.6 ENCODE 0.4 -8.1 -8088 0 DPF2 ZNF664 ZNF217 JUND GLIS1 HNF4A FOS FOSL2 DGKA GSTP1P1
GH12H055912 0.5 dbSUPER 0.4 -13.2 -13177 2 JUND IKZF1 ID3 SPI1 TMEM198B DNAJC14 MMP19 CDK2 RAB5B PMEL ORMDL2 SARNP PYM1 BLOC1S1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DGKA on UCSC Golden Path with GeneCards custom track

Promoters for DGKA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000052458 181 2201 HDGF PKNOX1 ARNT SIN3A FEZF1 YBX1 ZNF2 ZBTB7B YY1 ZNF143

Genomic Location for DGKA Gene

Chromosome:
12
Start:
55,927,319 bp from pter
End:
55,954,027 bp from pter
Size:
26,709 bases
Orientation:
Plus strand

Genomic View for DGKA Gene

Genes around DGKA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGKA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGKA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKA Gene

Proteins for DGKA Gene

  • Protein details for DGKA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23743-DGKA_HUMAN
    Recommended name:
    Diacylglycerol kinase alpha
    Protein Accession:
    P23743
    Secondary Accessions:
    • O75481
    • O75482
    • O75483
    • O95217
    • Q3ZE25
    • Q8IZ56
    • Q8N5Q2

    Protein attributes for DGKA Gene

    Size:
    735 amino acids
    Molecular mass:
    82630 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for DGKA Gene

    Alternative splice isoforms for DGKA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DGKA Gene

Selected DME Specific Peptides for DGKA Gene

P23743:
  • TTKTLPMQ
  • KSGGKQG
  • HGGSNLWG
  • NNYFSIGVDASIAHRFH
  • CGGDGTVGW
  • ITDPDILKTCVPD
  • DFAQLQKY
  • PEKFNSR
  • VNPKSGG
  • GLHCVWCHLEIHDDCL
  • SGRCDRCQKKIR
  • PCEVSTYAKSRKDIGVQ
  • NKLWYFE
  • ECDCGLLRDHILPP
  • DRNGILDS
  • PLGTGNDL
  • PEDKLEFTFKLYD
  • SDKRLEVVG
  • VYCNLCE
  • ILPPSSI
  • PMQIDGEPWMQ
  • LEVVGLEGA
  • GKQGLSC
  • WDVSELRPILQEMM
  • EFATSESIFSTCKKLEES
  • PLLVLLG
  • TVEICGK

Post-translational modifications for DGKA Gene

  • Ubiquitination at isoforms=2, 318, posLast=239239, isoforms=249, isoforms=263, isoforms=353, posLast=411411, isoforms=484, posLast=493493, and posLast=634634
  • Modification sites at PhosphoSitePlus

Domains & Families for DGKA Gene

Gene Families for DGKA Gene

Suggested Antigen Peptide Sequences for DGKA Gene

Graphical View of Domain Structure for InterPro Entry

P23743

UniProtKB/Swiss-Prot:

DGKA_HUMAN :
  • Belongs to the eukaryotic diacylglycerol kinase family.
Family:
  • Belongs to the eukaryotic diacylglycerol kinase family.
genes like me logo Genes that share domains with DGKA: view

Function for DGKA Gene

Molecular function for DGKA Gene

GENATLAS Biochemistry:
diacylglycerol kinase,86kDa,putative modulator of protein kinase C,in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated by calcium and phosphatidylserine. Phosphorylated by protein kinase C.
UniProtKB/Swiss-Prot Function:
Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity.

Enzyme Numbers (IUBMB) for DGKA Gene

Gene Ontology (GO) - Molecular Function for DGKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003951 NAD+ kinase activity IEA --
GO:0004143 diacylglycerol kinase activity TAS --
GO:0005509 calcium ion binding IEA --
GO:0005524 ATP binding IEA --
GO:0005543 phospholipid binding IEA --
genes like me logo Genes that share ontologies with DGKA: view
genes like me logo Genes that share phenotypes with DGKA: view

Animal Models for DGKA Gene

MGI Knock Outs for DGKA:

Animal Model Products

CRISPR Products

miRNA for DGKA Gene

miRTarBase miRNAs that target DGKA

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DGKA
  • Applied Biological Materials Clones for DGKA
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DGKA Gene

Localization for DGKA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DGKA gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DGKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DGKA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DGKA Gene

Pathways & Interactions for DGKA Gene

genes like me logo Genes that share pathways with DGKA: view

SIGNOR curated interactions for DGKA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DGKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006654 phosphatidic acid biosynthetic process IDA 22627129
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0008152 metabolic process IEA --
GO:0016310 phosphorylation IEA --
GO:0030168 platelet activation TAS --
genes like me logo Genes that share ontologies with DGKA: view

Drugs & Compounds for DGKA Gene

(6) Drugs for DGKA Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin E Approved, Vet_approved Nutra Target 428,431
Dioctanoylglycol Pharma Diacylglycerol kinase inhibitor 0
R 59-022 Pharma Diacylglycerol kinase inhibitor; increases PKC activity 0
calcium Nutra 0
ATP Nutra Agonist 0

(148) Additional Compounds for DGKA Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-behenoyl-sn-glycerol
  • 1-Tetradecanoyl-3-docosanoyl-sn-glycerol
  • DAG(14:0/0:0/22:0)
  • DAG(36:0)
  • DG(36:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(2) Tocris Compounds for DGKA Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor 627-86-1
R 59-022 Diacylglycerol kinase inhibitor; increases PKC activity 93076-89-2

(2) ApexBio Compounds for DGKA Gene

Compound Action Cas Number
Dioctanoylglycol 627-86-1
R 59-022 93076-89-2
genes like me logo Genes that share compounds with DGKA: view

Drug Products

Transcripts for DGKA Gene

Unigene Clusters for DGKA Gene

Diacylglycerol kinase, alpha 80kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DGKA
  • Applied Biological Materials Clones for DGKA
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DGKA Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15a ·
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - -
SP5:
SP6: - - - - - - - - - -
SP7: - -
SP8: - - - - - - -
SP9: - - - - -
SP10: - - - - -
SP11: - -
SP12:
SP13: - - - -
SP14: - - - - -
SP15: - - - -
SP16:
SP17:
SP18:

ExUns: 15b ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - -
SP5: - -
SP6:
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17: -
SP18:

Relevant External Links for DGKA Gene

GeneLoc Exon Structure for
DGKA
ECgene alternative splicing isoforms for
DGKA

Expression for DGKA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DGKA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DGKA Gene

This gene is overexpressed in Whole Blood (x5.1) and Esophagus - Mucosa (x4.9).

Protein differential expression in normal tissues from HIPED for DGKA Gene

This gene is overexpressed in Lymph node (24.5), Peripheral blood mononuclear cells (11.7), Tlymphocyte (11.0), and CD4 Tcells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DGKA Gene



Protein tissue co-expression partners for DGKA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DGKA Gene:

DGKA

SOURCE GeneReport for Unigene cluster for DGKA Gene:

Hs.524488

mRNA Expression by UniProt/SwissProt for DGKA Gene:

P23743-DGKA_HUMAN
Tissue specificity: Lymphocytes and oligodendroglial cells.

Evidence on tissue expression from TISSUES for DGKA Gene

  • Nervous system(4.7)
  • Blood(4.3)
  • Lymph node(2.1)
  • Skin(2)
genes like me logo Genes that share expression patterns with DGKA: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DGKA Gene

Orthologs for DGKA Gene

This gene was present in the common ancestor of animals.

Orthologs for DGKA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DGKA 33 34
  • 99.64 (n)
cow
(Bos Taurus)
Mammalia DGKA 33 34
  • 92.04 (n)
dog
(Canis familiaris)
Mammalia DGKA 33 34
  • 91.5 (n)
mouse
(Mus musculus)
Mammalia Dgka 33 16 34
  • 83.45 (n)
rat
(Rattus norvegicus)
Mammalia Dgka 33
  • 83.43 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DGKA 34
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 59 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia DGKA 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dgka 33
  • 64.79 (n)
zebrafish
(Danio rerio)
Actinopterygii dgkaa 33 34
  • 64.6 (n)
DGKA (1 of 2) 34
  • 50 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6786 33
fruit fly
(Drosophila melanogaster)
Insecta Dgk 35 34
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea dgk-3 35 34
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10986 34
  • 44 (a)
OneToMany
Species where no ortholog for DGKA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DGKA Gene

ENSEMBL:
Gene Tree for DGKA (if available)
TreeFam:
Gene Tree for DGKA (if available)

Paralogs for DGKA Gene

Paralogs for DGKA Gene

genes like me logo Genes that share paralogs with DGKA: view

Variants for DGKA Gene

Sequence variations from dbSNP and Humsavar for DGKA Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000046334 -- 55,950,395(+) TCCAC(C/T)TCCTG intron-variant
rs1000063786 -- 55,944,180(+) CTGTA(A/C/G)TCCCA intron-variant
rs1000078833 -- 55,950,613(+) ATTTT(G/T)ATATT intron-variant
rs1000242782 -- 55,954,069(+) AATGA(C/T)GTAGA downstream-variant-500B
rs1000276219 -- 55,932,369(+) GGAGG(A/G)ATGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DGKA Gene

Variant ID Type Subtype PubMed ID
nsv1051961 CNV gain 25217958
nsv832424 CNV loss 17160897

Variation tolerance for DGKA Gene

Residual Variation Intolerance Score: 10.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DGKA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DGKA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGKA Gene

Disorders for DGKA Gene

Relevant External Links for DGKA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DGKA

No disorders were found for DGKA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DGKA Gene

Publications for DGKA Gene

  1. Assignment of the human diacylglycerol kinase gene (DAGK) to 12q13.3 using fluorescence in situ hybridization analysis. (PMID: 7959783) Hart TC … Pettenati MJ (Genomics 1994) 2 3 4 60
  2. Assignment of the gene for diacylglycerol kinase (DAGK) to human chromosome 12. (PMID: 8180475) Hart TC … Van Dyke TE (Mammalian genome : official journal of the International Mammalian Genome Society 1994) 2 3 4 60
  3. Diacylglycerol kinase alpha mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI. (PMID: 20160093) Chianale F … Graziani A (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 22 60
  4. Diacylglycerol kinase alpha enhances protein kinase Czeta-dependent phosphorylation at Ser311 of p65/RelA subunit of nuclear factor-kappaB. (PMID: 19751727) Kai M … Sakane F (FEBS letters 2009) 3 22 60
  5. Lck-dependent tyrosine phosphorylation of diacylglycerol kinase alpha regulates its membrane association in T cells. (PMID: 18424699) Merino E … Mérida I (Journal of immunology (Baltimore, Md. : 1950) 2008) 3 22 60

Products for DGKA Gene

  • Addgene plasmids for DGKA

Sources for DGKA Gene

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