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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DGKA Gene

protein-coding GIFtS: 64
GCID: GC12P056324

diacylglycerol kinase, alpha 80kDa

(Previous names: diacylglycerol kinase, alpha (80kD) )
(Previous symbols: DAGK, DAGK1)

Explore 7 diseases affiliated with
DGKA via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Diacylglycerol Kinase, Alpha 80kDa¹ ²		80 KDa Diacylglycerol Kinase² ³
DAGK1¹ ² ³ ⁵		DAG Kinase Alpha² ³
DAGK¹ ² ³		EC 2.7.1.107³ ⁸
DGK-Alpha¹		Diacylglycerol Kinase, Alpha (80kD)¹
Diglyceride Kinase Alpha² ³		Diacylglycerol Kinase Alpha²

External Ids:	HGNC: 2849¹	Entrez Gene: 1606²	Ensembl: ENSG00000065357⁷	OMIM: 125855⁵	UniProtKB: P23743³

Export aliases for DGKA gene to outside databases

Previous GC identifers: GC12M056229 GC12U900027 GC12P056042 GC12P054611 GC12P053363

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DGKA:

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that

competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also

plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic

acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been

identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DGKA_HUMAN, P23743

Function: Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the

resynthesis of phosphatidylinositols and attenuating protein kinase C activity

summary for DGKA:

Diacylglycerol kinases (DGKs) are a group of ten enzymes (DGKalpha, DGKbeta, DGKgamma, DGKdelta, DGKepsilon,

DGKzeta, DGKeta, DGKtheta, DGKiota and DGKkappa) that metabolize 1,2,diacylglycerol (DAG) to produce

phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain, two cysteine-rich

Zn2+-finger motifs that bind DAG and an ATP-binding site, whilst the regulatory domain varies. DGKs are

widely distributed throughout mammalian tissues and different isozymes have different subcellular

localizations; some are cytosolic (for example DGKalpha), some are membrane-bound (for example DGKgamma is

associated with the Golgi membrane) and some are nuclear (for example DGKzeta. DGKs have diverse biological

roles as they participate in signal transduction by modulating levels of DAG in a variety of cellular

responses to extracellular stimuli.

Gene Wiki entry for DGKA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DGKA gene promoter:
AREB6 Egr-2 p53 c-Myb c-Ets-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DGKA promoter sequence

Search SABiosciences Chromatin IP Primers for DGKA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DGKA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3 Ensembl cytogenetic band: 12q13.2 HGNC cytogenetic band: 12q13.3

DGKA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DGKA gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P056324: view genomic region (about GC identifiers)

Start:	56,321,103 bp from pter	End:	56,347,811 bp from pter
Size:	26,709 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DGKA_HUMAN, P23743 (See protein sequence)

Recommended Name: Diacylglycerol kinase alpha

Size: 735 amino acids; 82630 Da

Subunit: Monomer

1 PDB 3D structure from and Proteopedia for DGKA:

1TUZ (3D)

Secondary accessions: O75481 O75482 O75483 O95217 Q8IZ56 Q8N5Q2

Alternative splicing: 2 isoforms: P23743-1 P23743-2 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for DGKA: NX_P23743

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P23743

4/27 DME Specific Peptides for DGKA (P23743) (see all 27)

GKQGLSC

VYCNLCE

PEKFNSR

KSGGKQG

DGKA Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001336.2 NP_958852.1 NP_958853.1 NP_963848.1

ENSEMBL proteins:

ENSP00000446515 ENSP00000449178 ENSP00000328405 ENSP00000452353 ENSP00000450977

ENSP00000451743 ENSP00000446605 ENSP00000448565 ENSP00000447050 ENSP00000450608

ENSP00000450359 ENSP00000385792 ENSP00000450999 ENSP00000451814 ENSP00000402307

ENSP00000451266 ENSP00000447460 ENSP00000449923 ENSP00000447949 ENSP00000451330

ENSP00000451518 ENSP00000377703

Reactome Protein details: P23743
Human Recombinant Protein Products:

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	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005829	cytosol	IEA	--
GO:0005886	plasma membrane	TAS	--

DGKA for ontologies About GeneDecksing

DGKA Antibody Products:

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DGKA for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR001206 Diacylglycerol_kinase_cat_dom

IPR002219 Prot_Kinase_C-like_PE/DAG-bd

IPR000756 Diacylglycerol_kin_accessory

IPR018247 EF_Hand_1_Ca_BS

IPR011992 EF-hand-like_dom

Graphical View of Domain Structure for InterPro Entry P23743

ProtoNet protein and cluster: P23743

1 Blocks protein family: IPB000756 Diacylglycerol kinase accessory domain (presumed)

UniProtKB/Swiss-Prot: DGKA_HUMAN, P23743

Similarity: Belongs to the eukaryotic diacylglycerol kinase family

Similarity: Contains 1 DAGKc domain

Similarity: Contains 2 EF-hand domains

Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DGKA_HUMAN, P23743

Function: Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the

resynthesis of phosphatidylinositols and attenuating protein kinase C activity

Catalytic activity: ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate

Enzyme regulation: Stimulated by calcium and phosphatidylserine. Phosphorylated by protein kinase C

Genatlas biochemistry entry for DGKA:

diacylglycerol kinase,86kDa,putative modulator of protein kinase C,in signal transduction

Enzyme Number (IUBMB): EC 2.7.1.107¹ ²

miRNA Products:		OriGene 3'-UTR Clone (see all 4): DGKA Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DGKA
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate DGKA:
		hsa-miR-200c hsa-miR-885-3p hsa-miR-429 hsa-miR-1252 hsa-miR-1827 hsa-miR-200b
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGKA

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004143	diacylglycerol kinase activity	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0005543	phospholipid binding	IEA	--
GO:0046872	metal ion binding	--	--

DGKA for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for DGKA:

Increased apoptosis

Increased cell number in G1, s

Animal Models:
Mouse knock-out Dgka^tm1Xpz for DGKA
4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Dgka):

cellular

hematopoietic system

immune system

reproductive system

DGKA for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation

1.00

Hemostasis

0.43

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Effects of PIP2 hydrolysis

Effects of PIP2 hydrolysis

1.00

Glycerolipid metabolism

Glycerolipid metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for DGKA

Calcineurin-regulated NFAT-dependent transcription in lymphocytes

5/8 Reactome Pathways for DGKA (see all 8)

	GPCR downstream signaling
	Hemostasis
	Effects of PIP2 hydrolysis
	Signal Transduction
	Gastrin-CREB signalling pathway via PKC and MAPK

4 Kegg Pathways (Kegg details for DGKA):

	Glycerolipid metabolism
	Glycerophospholipid metabolism
	Metabolic pathways
	Phosphatidylinositol signaling system

DGKA for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DGKA

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/45 Interacting proteins for DGKA (P23743^{2, 3} ENSP00000328405⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 45)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SRC	P12931²^,³, ENSP00000350941⁴	MINT-8033370 MINT-8033355 I2D: score=3 STRING: ENSP00000350941
IL2	P60568³, ENSP00000226730⁴	I2D: score=1 STRING: ENSP00000226730
IL21	Q9HBE4³, ENSP00000264497⁴	I2D: score=1 STRING: ENSP00000264497
SMAD2	Q15796³, ENSP00000262160⁴	I2D: score=1 STRING: ENSP00000262160
SREK1	Q8WXA9³, ENSP00000334538⁴	I2D: score=1 STRING: ENSP00000334538

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	IEA	--
GO:0007596	blood coagulation	TAS	--
GO:0030168	platelet activation	TAS	--
GO:0035556	intracellular signal transduction	IEA	--

DGKA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

DGKA for compounds About GeneDecksing

EMD Millipore small molecules for DGKA:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for DGKA available from Tocris Bioscience About this table

Compound	Action	CAS #
R 59-022	Diacylglycerol kinase inhibitor; increases PKC activity	[93076-89-2]
Dioctanoylglycol	Diacylglycerol kinase inhibitor	[627-86-1]

10/987 HMDB Compounds for DGKA (see all 987) About this table

Compound	Synonyms	CAS #	PubMed Ids
DG(16:0e/18:0/0:0)	2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)	--	12486725
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Calcium	Ca (see all 2)	7440-70-2	--
DG(14:0/14:0/0:0)	DAG(14:0/14:0) (see all 9)	--	--
DG(14:0/14:1(9Z)/0:0)	DAG(14:0/14:1) (see all 15)	--	--
DG(14:0/15:0/0:0)	Diacylglycerol(29:0) (see all 9)	--	--
DG(14:0/16:0/0:0)	DAG(30:0) (see all 9)	--	--
DG(14:0/16:1(9Z)/0:0)	DG(30:1) (see all 15)	--	--
DG(14:0/18:0/0:0)	DG(14:0/18:0) (see all 9)	--	--

1 DrugBank Compound for DGKA About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Vitamin E	alpha-Tocopherol (see all 2)	59-02-9	target	--	17139284 17016423

4 Novoseek chemical compound relationships for DGKA gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	44.8	7	18424699 (3), 17700527 (2), 19491056 (1), 15773894 (1)
phosphoinositide	29.6	1	12832407 (1)
lipid	17.3	6	11467959 (3), 12832407 (1)
calcium	0	1	12832407 (1)

Search CenterWatch for drugs/clinical trials and news about DGKA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DGKA gene (4 alternative transcripts):

NM_001345.4 NM_201444.2 NM_201445.1 NM_201554.1

Unigene Cluster for DGKA:

Diacylglycerol kinase, alpha 80kDa

Hs.524488 [show with all ESTs]

Unigene Representative Sequence: AK226134

18/49 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 49):

ENST00000546878 ENST00000546995 ENST00000547015 ENST00000331886(uc001sih.1 uc001sii.1 uc009zod.1 uc001sij.3)

ENST00000555090 ENST00000549629 ENST00000555218 ENST00000548479 ENST00000547324

ENST00000553084 ENST00000547358(uc009zoc.1) ENST00000548549 ENST00000549368

ENST00000548407 ENST00000554434 ENST00000555025 ENST00000551615 ENST00000547535

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		hsa-miR-200c hsa-miR-885-3p hsa-miR-429 hsa-miR-1252 hsa-miR-1827 hsa-miR-200b
		SwitchGear 3'UTR luciferase reporter plasmid: DGKA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AF064767.1 AF064768.1 AF064769.1 AF064770.1 AF064771.1 AK226134.1 AK303320.1 AK307685.1

AK309939.1 AK310600.1 AY930112.1 BC008292.1 BC023523.2 BC031870.2 X62535.1

24/35 DOTS entries (see all 35):

DT.100649148 DT.95151781 DT.97844658 DT.313862 DT.100649146 DT.100867421 DT.121207978 DT.86859208

DT.95136199 DT.95141713 DT.91746710 DT.92436769 DT.95141742 DT.121207996 DT.92028038 DT.92436768

DT.121207930 DT.121207932 DT.95141714 DT.97780024 DT.70104591 DT.75103892 DT.75189519 DT.100649147

24/217 AceView cDNA sequences (see all 217):

AK122973 BQ054457 CA414470 BM910598 BC023523 AW849539 NM_201445 AL551428

CB123870 NM_201554 BG752623 AK127093 BQ024673 BQ428244 CR616473 BQ938230

CR625683 BG742905 NM_201444 BQ641370 BQ642739 NM_001345 AI028222 BQ943057

GeneLoc Exon Structure

5/18 Alternative Splicing Database (ASD) splice patterns (SP) for DGKA (see all 18) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	·	10c	^	11	^	12a	·	12b	^	13	^	14a	·	14b	·	14c	^	15a	·
SP1:															-				-						-						-				-		-		-										-		-
SP2:																			-						-						-				-		-		-										-		-
SP3:															-				-						-						-				-		-		-										-		-
SP4:																									-						-				-		-		-										-		-
SP5:

ExUns:	15b	^	16a	·	16b	·	16c	^	17	^	18a	·	18b	^	19	^	20	^	21	^	22	^	23	^	24	^	25	^	26	^	27	^	28	^	29	^	30a	·	30b
SP1:			-				-						-										-
SP2:			-				-						-										-
SP3:	-		-				-						-										-
SP4:			-				-						-										-
SP5:							-						-

ECgene alternative splicing isoforms for DGKA

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DGKA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGCACACACA

About this image
See DGKA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DGKA

SOURCE GeneReport for Unigene cluster: Hs.524488

UniProtKB/Swiss-Prot: DGKA_HUMAN, P23743

Tissue specificity: Lymphocytes and oligodendroglial cells

SABiosciences Expression via Pathway-Focused PCR Array including DGKA:

T-Cell Anergy & Immune Tolerance in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGKA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for DGKA gene from 6/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	DGKA⁶	--	59(a)	1 ↔ 1	GL343198.1(3307320-3334002)
zebrafish (Danio rerio)	Actinopterygii	dgkaa¹	diacylglycerol kinase, alpha a	64.56(n) 63.57(a)		724010 NM_001045315.1 NP_001038780.1
fruit fly (Drosophila melanogaster)	Insecta	Dgk³	phosphatidylinositol biosynthesis diacylglycerol more	51(a)		43E18 --
worm (Caenorhabditis elegans)	Secernentea	dgk-3³	Diacylglycerol kinase	44(a)		III(9234802-9239752) --
thale cress (Arabidopsis thaliana)	eudicotyledons	DGK2⁶ DGK1⁶ (see all 7)	diacylglycerol kinase1 (see all 7)	24(a) 23(a) (see all 7)	many ↔ many many ↔ many (see all 7)	5(25518641-25523621) 5(2524778-2529330)
rice (Oryza sativa)	Liliopsida	-- -- (see all 8)	diacylglycerol kinase 1, putative, expressed (see all 8)	25(a) 22(a) (see all 8)	many ↔ many many ↔ many (see all 8)	12(6728516-6733263) 3(17753599-17759915)

ENSEMBL Gene Tree for DGKA (if available)
TreeFam Gene Tree for DGKA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for DGKA gene

DGKH² DGKG² DGKQ² DGKB² DGKD² DGKI² DGKE² DGKZ²

7 SIMAP similar genes for DGKA using alignment to 14 protein entries: DGKA_HUMAN (see all proteins):

DAGK1 DGKB DGKG DGKZ DGKE DGKI

DGKH

DGKA for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs115388761^1,2	C,F,	--	53361955(+)	`GCATAC/TGATAC`	1	--	us2k¹		1		WA	118
rs7306585^1,2	C,	--	53362578(+)	`ACAGAA/TCCTAA`	1	--	us2k¹		0	--	--	--	--
rs185654186^1,2		--	56322972(+)	`TGTTAA/TTGCAA`	1	--	us2k¹		0	--	--	--	--
rs190115993^1,2		--	56323269(+)	`TCAGCA/GCTAGG`	1	--	us2k¹		0	--	--	--	--
rs144202495^1,2		--	56323603(+)	`AAGAAA/GTCTAG`	1	--	us2k¹		0	--	--	--	--
rs118164681^1,2		--	56323795(+)	`AAGCTG/AAGTGC`	1	--	us2k¹		1		NA	120
rs146746685^1,2		--	56323890(+)	`TCTTAC/TATTGT`	4	--	us2k¹		0	--	--	--	--
rs139206910^1,2		--	56323912(+)	`AAGTAG/TCTCAG`	4	--	us2k¹		0	--	--	--	--
rs149966758^1,2		--	56323939(+)	`ACACAG/TTGCAC`	4	--	us2k¹		0	--	--	--	--
rs57317928^1,2	C,	--	56324151(+)	`TTTTT-/GTTTTT`	4	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DGKA (56321103 - 56347811 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DGKA: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DGKA

DNA2.0 Custom Variant and Variant Library Synthesis for DGKA

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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DGKA for disorders           About GeneDecksing

OMIM gene information: 125855    OMIM disorders: --

7 diseases for DGKA:    About MalaCards

aggressive periodontitis periodontitis lung adenocarcinoma pharyngitis

adenocarcinoma melanoma neuronitis

Export disorders for DGKA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DGKA gene, integrated from 9 sources (see all 63):
(articles sorted by number of sources associating them with DGKA)

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Assignment of the gene for diacylglycerol kinase (DAGK) to human chromosome 12. (PubMed id 8180475)^{1, 2, 3} Hart T.C.... van Dyke T.E. (1994)
Assignment of the human diacylglycerol kinase gene (DAGK) to 12q13.3 using fluorescence in situ hybridization analysis. (PubMed id 7959783)^{1, 2, 3} Hart T.C....Pettenati M.J. (1994)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Purification, cDNA-cloning and expression of human diacylglycerol kinase. (PubMed id 2175712)^{1, 2} Schaap D....van der Bendl R.L. (1990)
Lck-dependent tyrosine phosphorylation of diacylglycerol kinase alpha regulates its membrane association in T cells. (PubMed id 18424699)^{1, 9} Merino E....Merida I. (2008)
Diacylglycerol kinase alpha regulates the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes. (PubMed id 15870081)^{1, 9} Alonso R....Izquierdo M. (2005)
Diacylglycerol kinase-alpha phosphorylation by Src on Y335 is required for activation, membrane recruitment and Hgf-induced cell motility. (PubMed id 17700527)^{1, 9} Baldanzi G....Graziani A. (2008)
Diacylglycerol kinase alpha enhances protein kinase C zeta-dependent phosphorylation at Ser311 of p65/RelA subunit of nuclear factor- kappaB. (PubMed id 19751727)^{1, 9} Kai M....Sakane F. (2009)
Activation of diacylglycerol kinase alpha is required for VEGF-induced angiogenic signaling in vitro. (PubMed id 15122338)^{1, 9} Baldanzi G....Graziani A. (2004)
Src-mediated activation of alpha-diacylglycerol kinase is required for hepatocyte growth factor-induced cell motility. (PubMed id 10970854)^{1, 9} Cutrupi S....Graziani A. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1606	HGNC: 2849	AceView: DGKA	Ensembl:ENSG00000065357	euGenes: HUgn1606
ECgene: DGKA	Kegg: 1606	H-InvDB: DGKA

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DGKA	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for DGKA	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for DGKA gene
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Patent Information for DGKA gene:
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GeneCards and IP:
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diacylglycerol kinase, alpha 80kDa

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DGKA Gene

diacylglycerol kinase, alpha 80kDa

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