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Aliases for DGKA Gene

Aliases for DGKA Gene

  • Diacylglycerol Kinase Alpha 2 3 5
  • Diacylglycerol Kinase, Alpha 80kDa 2 3
  • 80 KDa Diacylglycerol Kinase 3 4
  • Diglyceride Kinase Alpha 3 4
  • DAG Kinase Alpha 3 4
  • EC 2.7.1.107 4 61
  • DGK-Alpha 3 4
  • DAGK1 3 4
  • DAGK 3 4
  • Diacylglycerol Kinase, Alpha (80kD) 2

External Ids for DGKA Gene

Previous HGNC Symbols for DGKA Gene

  • DAGK
  • DAGK1

Previous GeneCards Identifiers for DGKA Gene

  • GC12M056229
  • GC12U900027
  • GC12P056042
  • GC12P054611
  • GC12P056324
  • GC12P053363

Summaries for DGKA Gene

Entrez Gene Summary for DGKA Gene

  • The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for DGKA Gene

DGKA (Diacylglycerol Kinase Alpha) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Effects of PIP2 hydrolysis. GO annotations related to this gene include calcium ion binding and NAD+ kinase activity. An important paralog of this gene is DGKB.

UniProtKB/Swiss-Prot for DGKA Gene

  • Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity.

Tocris Summary for DGKA Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.

Gene Wiki entry for DGKA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGKA Gene

Genomics for DGKA Gene

Regulatory Elements for DGKA Gene

Enhancers for DGKA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F055925 1.8 FANTOM5 Ensembl ENCODE 9.9 +6.0 6020 16.2 CREB3L1 DMAP1 YBX1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 BAZ2A RN7SL809P ZC3H10 CDK2 RBMS2 NABP2 TMEM198B RNU6-343P PYM1 NACA
GH12F055955 1.1 Ensembl ENCODE 12.9 +29.7 29703 4.0 CBX3 PKNOX1 RAD21 ZEB1 RFX5 GLIS2 RCOR1 FOS DEK ZNF362 DGKA RPS26 ORMDL2 SARNP MMP19 RDH5 MYL6B CDK2 PYM1
GH12F055908 1.1 Ensembl ENCODE 0.3 -17.9 -17910 1.5 HDGF ARID4B THRB RAD21 SCRT2 ZNF143 CREM ZNF263 ZNF362 ZNF654 PYM1 GSTP1P1 DGKA
GH12F055906 1 ENCODE 0.3 -21.1 -21098 0.2 HDGF ATF1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF48 ZNF121 GLIS2 RN7SL809P RPL41 RBMS2 PHC1P1 BAZ2A RNU6-343P STAT2 CDK2 ESYT1 NACA
GH12F055919 0.6 ENCODE 0.4 -8.1 -8088 0.2 ZNF664 GLIS1 DPF2 FOS FOSL2 DGKA GSTP1P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DGKA on UCSC Golden Path with GeneCards custom track

Genomic Location for DGKA Gene

Chromosome:
12
Start:
55,927,319 bp from pter
End:
55,954,027 bp from pter
Size:
26,709 bases
Orientation:
Plus strand

Genomic View for DGKA Gene

Genes around DGKA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGKA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGKA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKA Gene

Proteins for DGKA Gene

  • Protein details for DGKA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23743-DGKA_HUMAN
    Recommended name:
    Diacylglycerol kinase alpha
    Protein Accession:
    P23743
    Secondary Accessions:
    • O75481
    • O75482
    • O75483
    • O95217
    • Q3ZE25
    • Q8IZ56
    • Q8N5Q2

    Protein attributes for DGKA Gene

    Size:
    735 amino acids
    Molecular mass:
    82630 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for DGKA Gene

    Alternative splice isoforms for DGKA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DGKA Gene

Selected DME Specific Peptides for DGKA Gene

P23743:
  • TTKTLPMQ
  • KSGGKQG
  • HGGSNLWG
  • NNYFSIGVDASIAHRFH
  • CGGDGTVGW
  • ITDPDILKTCVPD
  • DFAQLQKY
  • PEKFNSR
  • VNPKSGG
  • GLHCVWCHLEIHDDCL
  • SGRCDRCQKKIR
  • PCEVSTYAKSRKDIGVQ
  • NKLWYFE
  • ECDCGLLRDHILPP
  • DRNGILDS
  • PLGTGNDL
  • PEDKLEFTFKLYD
  • SDKRLEVVG
  • VYCNLCE
  • ILPPSSI
  • PMQIDGEPWMQ
  • LEVVGLEGA
  • GKQGLSC
  • WDVSELRPILQEMM
  • EFATSESIFSTCKKLEES
  • PLLVLLG
  • TVEICGK

Post-translational modifications for DGKA Gene

  • Ubiquitination at Lys 18, Lys 239, Lys 249, Lys 263, Lys 353, Lys 411, Lys 484, Lys 493, and Lys 634
  • Modification sites at PhosphoSitePlus

Domains & Families for DGKA Gene

Suggested Antigen Peptide Sequences for DGKA Gene

Graphical View of Domain Structure for InterPro Entry

P23743

UniProtKB/Swiss-Prot:

DGKA_HUMAN :
  • Contains 1 DAGKc domain.
  • Belongs to the eukaryotic diacylglycerol kinase family.
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
Domain:
  • Contains 1 DAGKc domain.
  • Contains 2 EF-hand domains.
Family:
  • Belongs to the eukaryotic diacylglycerol kinase family.
Similarity:
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
genes like me logo Genes that share domains with DGKA: view

Function for DGKA Gene

Molecular function for DGKA Gene

GENATLAS Biochemistry:
diacylglycerol kinase,86kDa,putative modulator of protein kinase C,in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated by calcium and phosphatidylserine. Phosphorylated by protein kinase C.
UniProtKB/Swiss-Prot Function:
Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity.

Enzyme Numbers (IUBMB) for DGKA Gene

Gene Ontology (GO) - Molecular Function for DGKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004143 diacylglycerol kinase activity IEA,TAS --
GO:0005509 calcium ion binding IEA --
GO:0005524 ATP binding IEA --
GO:0005543 phospholipid binding IEA --
GO:0016301 kinase activity IEA,IDA 18004883
genes like me logo Genes that share ontologies with DGKA: view
genes like me logo Genes that share phenotypes with DGKA: view

Animal Models for DGKA Gene

MGI Knock Outs for DGKA:

Animal Model Products

miRNA for DGKA Gene

miRTarBase miRNAs that target DGKA

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DGKA Gene

Localization for DGKA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DGKA gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for DGKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DGKA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DGKA Gene

Pathways & Interactions for DGKA Gene

genes like me logo Genes that share pathways with DGKA: view

SIGNOR curated interactions for DGKA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DGKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006654 phosphatidic acid biosynthetic process IDA 22627129
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0016310 phosphorylation IEA --
GO:0030168 platelet activation TAS --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with DGKA: view

Drugs & Compounds for DGKA Gene

(6) Drugs for DGKA Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin E Approved, Vet_approved Nutra Target 406,403
Adenosine triphosphate Approved Nutra 0
Dioctanoylglycol Pharma Diacylglycerol kinase inhibitor 0
R 59-022 Pharma Diacylglycerol kinase inhibitor; increases PKC activity 0
calcium Nutra 0

(148) Additional Compounds for DGKA Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(2) Tocris Compounds for DGKA Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor 627-86-1
R 59-022 Diacylglycerol kinase inhibitor; increases PKC activity 93076-89-2

(2) ApexBio Compounds for DGKA Gene

Compound Action Cas Number
Dioctanoylglycol 627-86-1
R 59-022 93076-89-2
genes like me logo Genes that share compounds with DGKA: view

Transcripts for DGKA Gene

Unigene Clusters for DGKA Gene

Diacylglycerol kinase, alpha 80kDa:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DGKA Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15a ·
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - -
SP5:
SP6: - - - - - - - - - -
SP7: - -
SP8: - - - - - - -
SP9: - - - - -
SP10: - - - - -
SP11: - -
SP12:
SP13: - - - -
SP14: - - - - -
SP15: - - - -
SP16:
SP17:
SP18:

ExUns: 15b ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - -
SP5: - -
SP6:
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17: -
SP18:

Relevant External Links for DGKA Gene

GeneLoc Exon Structure for
DGKA
ECgene alternative splicing isoforms for
DGKA

Expression for DGKA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DGKA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DGKA Gene

This gene is overexpressed in Whole Blood (x5.1) and Esophagus - Mucosa (x4.9).

Protein differential expression in normal tissues from HIPED for DGKA Gene

This gene is overexpressed in Lymph node (24.5), Peripheral blood mononuclear cells (11.7), Tlymphocyte (11.0), and CD4 Tcells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DGKA Gene



Protein tissue co-expression partners for DGKA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DGKA Gene:

DGKA

SOURCE GeneReport for Unigene cluster for DGKA Gene:

Hs.524488

mRNA Expression by UniProt/SwissProt for DGKA Gene:

P23743-DGKA_HUMAN
Tissue specificity: Lymphocytes and oligodendroglial cells.
genes like me logo Genes that share expression patterns with DGKA: view

Orthologs for DGKA Gene

This gene was present in the common ancestor of animals.

Orthologs for DGKA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DGKA 34 35
  • 99.64 (n)