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Aliases for DGCR6L Gene

Aliases for DGCR6L Gene

  • DiGeorge Syndrome Critical Region Gene 6-Like 2 3 5
  • DiGeorge Syndrome Critical Region 6-Like Protein 3 4
  • DiGeorge Syndrome Critical Region Gene 6 Like 3
  • DGCR6 3

External Ids for DGCR6L Gene

Previous GeneCards Identifiers for DGCR6L Gene

  • GC22M017242
  • GC22M018676
  • GC22M003921

Summaries for DGCR6L Gene

Entrez Gene Summary for DGCR6L Gene

  • This gene, the result of a duplication at this locus, is one of two functional genes encoding nearly identical proteins that have similar expression patterns. The product of this gene is a protein that shares homology with the Drosophila gonadal protein, expressed in gonadal tissues and germ cells, and with the human laminin gamma-1 chain that functions in cell attachment and migration. This gene is located in a region of chromosome 22 implicated in the DiGeorge syndrome, one facet of a broader collection of anomalies referred to as the CATCH 22 syndrome. [provided by RefSeq, Jul 2008]

GeneCards Summary for DGCR6L Gene

DGCR6L (DiGeorge Syndrome Critical Region Gene 6-Like) is a Protein Coding gene. Diseases associated with DGCR6L include Digeorge Syndrome and Velocardiofacial Syndrome. An important paralog of this gene is LOC102724770.

UniProtKB/Swiss-Prot for DGCR6L Gene

  • May play a role in neural crest cell migration into the third and fourth pharyngeal pouches.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGCR6L Gene

Genomics for DGCR6L Gene

Regulatory Elements for DGCR6L Gene

Enhancers for DGCR6L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DGCR6L on UCSC Golden Path with GeneCards custom track

Promoters for DGCR6L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DGCR6L on UCSC Golden Path with GeneCards custom track

Genomic Location for DGCR6L Gene

20,314,238 bp from pter
20,320,105 bp from pter
5,868 bases
Minus strand

Genomic View for DGCR6L Gene

Genes around DGCR6L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGCR6L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGCR6L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGCR6L Gene

Proteins for DGCR6L Gene

  • Protein details for DGCR6L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein DGCR6L
    Protein Accession:
    Secondary Accessions:
    • A8K1N7
    • B3KMC0
    • D3DX29
    • Q9BW33

    Protein attributes for DGCR6L Gene

    220 amino acids
    Molecular mass:
    24932 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DGCR6L Gene

Proteomics data for DGCR6L Gene at MOPED

Post-translational modifications for DGCR6L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DGCR6L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DGCR6L Gene

Domains & Families for DGCR6L Gene

Protein Domains for DGCR6L Gene


Suggested Antigen Peptide Sequences for DGCR6L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the gonadal family.
  • Belongs to the gonadal family.
genes like me logo Genes that share domains with DGCR6L: view

No data available for Gene Families for DGCR6L Gene

Function for DGCR6L Gene

Molecular function for DGCR6L Gene

UniProtKB/Swiss-Prot Function:
May play a role in neural crest cell migration into the third and fourth pharyngeal pouches.

Phenotypes for DGCR6L Gene

genes like me logo Genes that share phenotypes with DGCR6L: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DGCR6L Gene

Localization for DGCR6L Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGCR6L Gene

Nucleus. Note=Predominantly nuclear.

Subcellular locations from

Jensen Localization Image for DGCR6L Gene COMPARTMENTS Subcellular localization image for DGCR6L gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for DGCR6L Gene

Pathways & Interactions for DGCR6L Gene

SuperPathways for DGCR6L Gene

No Data Available

Gene Ontology (GO) - Biological Process for DGCR6L Gene


No data available for Pathways by source and SIGNOR curated interactions for DGCR6L Gene

Drugs & Compounds for DGCR6L Gene

No Compound Related Data Available

Transcripts for DGCR6L Gene

Unigene Clusters for DGCR6L Gene

DiGeorge syndrome critical region gene 6-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DGCR6L Gene

No ASD Table

Relevant External Links for DGCR6L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DGCR6L Gene

mRNA expression in normal human tissues for DGCR6L Gene

Protein differential expression in normal tissues from HIPED for DGCR6L Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DGCR6L Gene

SOURCE GeneReport for Unigene cluster for DGCR6L Gene Hs.410965

mRNA Expression by UniProt/SwissProt for DGCR6L Gene

Tissue specificity: Widely expressed in fetal and adult tissues. Highest expression in liver, heart and skeletal muscle. Lower levels in pancreas and placenta. Weak expression in brain.
genes like me logo Genes that share expression patterns with DGCR6L: view

Protein tissue co-expression partners for DGCR6L Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DGCR6L Gene

Orthologs for DGCR6L Gene

This gene was present in the common ancestor of animals.

Orthologs for DGCR6L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DGCR6L 36
  • 96 (a)
(Canis familiaris)
Mammalia -- 36
  • 93 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
(Mus musculus)
Mammalia Dgcr6 36
  • 89 (a)
(Pan troglodytes)
Mammalia DGCR6L 36
  • 99 (a)
(Gallus gallus)
Aves DGCR6 36
  • 75 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 63 (a)
(Danio rerio)
Actinopterygii Dr.16559 35
dgcr6 36
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta gdl 36
  • 34 (a)
Species with no ortholog for DGCR6L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DGCR6L Gene

Gene Tree for DGCR6L (if available)
Gene Tree for DGCR6L (if available)

Paralogs for DGCR6L Gene

Paralogs for DGCR6L Gene

(1) SIMAP similar genes for DGCR6L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DGCR6L: view

Variants for DGCR6L Gene

Sequence variations from dbSNP and Humsavar for DGCR6L Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1056818 - 20,316,148(+) CTGAA(C/G)CACAG reference, missense
rs1056804 - 20,314,753(+) GCTGC(A/C/T)TTCCC reference, missense, utr-variant-3-prime
rs7235 -- 20,319,733(+) AACAC(A/G)GTGCC reference, synonymous-codon
rs2280116 -- 20,319,193(+) TGCTT(A/T)GGAAT intron-variant
rs2280117 -- 20,319,470(+) ACCCA(C/T)TGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DGCR6L Gene

Variant ID Type Subtype PubMed ID
nsv435744 CNV Deletion 17901297
nsv828938 CNV Gain 20364138
nsv828939 CNV Loss 20364138
nsv471183 CNV Loss 18288195
dgv1387e1 CNV Complex 17122850
dgv726n67 CNV Gain 20364138
dgv4855n71 CNV Loss 21882294
dgv4862n71 CNV Loss 21882294
nsv914360 CNV Gain 21882294
nsv914375 CNV Loss 21882294
nsv519102 CNV Loss 19592680
dgv16n31 CNV Duplication 19718026
nsv518950 CNV Gain 19592680

Variation tolerance for DGCR6L Gene

Residual Variation Intolerance Score: 59.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.53; 55.68% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DGCR6L Gene

Disorders for DGCR6L Gene

MalaCards: The human disease database

(2) MalaCards diseases for DGCR6L Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
digeorge syndrome
  • digeorge sequence
velocardiofacial syndrome
  • cayler cardiofacial syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DGCR6L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DGCR6L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DGCR6L Gene

Publications for DGCR6L Gene

  1. Two functional copies of the DGCR6 gene are present on human chromosome 22q11 due to a duplication of an ancestral locus. (PMID: 11157784) Edelmann L. … Morrow B.E. (Genome Res. 2001) 2 3 4 67
  2. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses. (PMID: 22458338) Simonis N. … Twizere J.C. (Retrovirology 2012) 3
  5. Dysregulation of DGCR6 and DGCR6L: psychopathological outcomes in chromosome 22q11.2 deletion syndrome. (PMID: 22832905) Das Chakraborty R. … Shashi V. (Transl Psychiatry 2012) 3

Products for DGCR6L Gene

Sources for DGCR6L Gene