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DGCR6 Gene

protein-coding   GIFtS: 53
GCID: GC22P018893

DiGeorge Syndrome Critical Region Gene 6

  See DGCR6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DiGeorge Syndrome Critical Region Gene 61 2
DiGeorge Syndrome Critical Region Protein 62
Protein DGCR62
DiGeorge Syndrome Critical Region 63

External Ids:    HGNC: 28461   Entrez Gene: 82142   Ensembl: ENSG000001836287   OMIM: 6012795   UniProtKB: Q141293   

Export aliases for DGCR6 gene to outside databases

Previous GC identifers: GC22P015834 GC22P017268 GC22P002515


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DGCR6 Gene:
DiGeorge syndrome, and more widely, the CATCH 22 syndrome, are associated with microdeletions in chromosomal
region 22q11.2. The product of this gene shares homology with the Drosophila melanogaster gonadal protein, which
participates in gonadal and germ cell development, and with the gamma-1 subunit of human laminin. This gene is a
candidate for involvement in DiGeorge syndrome pathology and in schizophrenia. (provided by RefSeq, Nov 2008)

GeneCards Summary for DGCR6 Gene:
DGCR6 (DiGeorge syndrome critical region gene 6) is a protein-coding gene. Diseases associated with DGCR6 include digeorge syndrome, and schizophrenia. An important paralog of this gene is DGCR6L.

UniProtKB/Swiss-Prot: DGCR6_HUMAN, Q14129
Function: May play a role in neural crest cell migration into the third and fourth pharyngeal pouches

Gene Wiki entry for DGCR6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the DGCR6 gene promoter:
         HEN1   CREB   Elk-1   Pax-3   Pax-5   deltaCREB   MyoD   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDGCR6 promoter sequence
   Search Chromatin IP Primers for DGCR6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DGCR6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21|22q11   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.21

DGCR6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DGCR6 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P018893:  view genomic region     (about GC identifiers)

Start:
18,893,541 bp from pter      End:
18,901,751 bp from pter
Size:
8,211 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DGCR6_HUMAN, Q14129 (See protein sequence)
Recommended Name: Protein DGCR6  
Size: 220 amino acids; 24989 Da
Sequence caution: Sequence=CAA65339.1; Type=Frameshift; Positions=69;
Secondary accessions: B2RCH5 D3DX15 Q9BY28

Explore the universe of human proteins at neXtProt for DGCR6: NX_Q14129

Explore proteomics data for DGCR6 at MOPED


See DGCR6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_005666.2  
ENSEMBL proteins: 
 ENSP00000402409   ENSP00000331681   ENSP00000467483   ENSP00000397633   ENSP00000476388  
 ENSP00000466276  

DGCR6 Human Recombinant Protein Products:

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antibodies-online proteins for DGCR6 (5 products) 

 
antibodies-online peptides for DGCR6

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antibodies-online antibodies for DGCR6 (23 products) 

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR010849 DGCR6

Graphical View of Domain Structure for InterPro Entry Q14129

ProtoNet protein and cluster: Q14129

1 Blocks protein domain: IPB010849 DiGeorge syndrome critical 6

UniProtKB/Swiss-Prot: DGCR6_HUMAN, Q14129
Similarity: Belongs to the gonadal family


Find genes that share domains with DGCR6           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: DGCR6_HUMAN, Q14129
Function: May play a role in neural crest cell migration into the third and fourth pharyngeal pouches
Induction: Increased levels in several tumor cell lines, including lung and colon adenocarcinomas and mammary
carcinomas. Strongly induced in Burkitt's lymphoma and lymphocytes transformed by EBV

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
     
Find genes that share ontologies with DGCR6           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for DGCR6:
 Increased gamma-H2AX phosphory 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for DGCR6

miRNA
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2 qRT-PCR Assays for microRNAs that regulate DGCR6:
hsa-miR-330-5p hsa-miR-326
SwitchGear 3'UTR luciferase reporter plasmidDGCR6 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for DGCR6
Predesigned siRNA for gene silencing in human, mouse, rat DGCR6

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Sino Biological Human cDNA Clone for DGCR6
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DGCR6
Addgene plasmids for DGCR6 

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGCR6


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
DGCR6_HUMAN, Q14129: Nucleus. Note=Predominantly nuclear
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
extracellular4
cytosol2
peroxisome1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005578proteinaceous extracellular matrix TAS8733130
GO:0005634nucleus IEA--

Find genes that share ontologies with DGCR6           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DGCR6
Interactions:

    Search GeneGlobe Interaction Network for DGCR6

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007155cell adhesion TAS8733130
GO:0009887organ morphogenesis TAS8733130

Find genes that share ontologies with DGCR6           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for DGCR6



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for DGCR6 gene: 
NM_005675.4  

Unigene Cluster for DGCR6:

DiGeorge syndrome critical region gene 6
Hs.474185  [show with all ESTs]
Unigene Representative Sequence: AK098780
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000413981(uc002zog.3) ENST00000331444(uc002zoh.4) ENST00000483718
ENST00000427407 ENST00000608842 ENST00000480608(uc002zoi.4) ENST00000477156
ENST00000436645
miRNA
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2 qRT-PCR Assays for microRNAs that regulate DGCR6:
hsa-miR-330-5p hsa-miR-326
SwitchGear 3'UTR luciferase reporter plasmidDGCR6 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for DGCR6
Predesigned siRNA for gene silencing in human, mouse, rat DGCR6
Clone
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GenScript: all cDNA clones in your preferred vector: DGCR6 (NM_005675)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DGCR6
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DGCR6
Addgene plasmids for DGCR6 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for DGCR6
OriGene qSTAR qPCR primer pairs in human, mouse for DGCR6
Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat DGCR6
  QuantiTect SYBR Green Assays in human, mouse, rat DGCR6
  QuantiFast Probe-based Assays in human, mouse, rat DGCR6

Additional mRNA sequence: 

AF228707.1 AK098780.1 AK315115.1 BC033306.1 BC047039.1 CR456434.1 CR542133.1 X96484.1 

10 DOTS entries:

DT.100796305  DT.95288412  DT.100796307  DT.100028214  DT.75183365  DT.416745  DT.100009741  DT.402246 
DT.97794752  DT.97845377 

Selected AceView cDNA sequences (see all 95):

AK098780 BQ639188 BM127525 BM548122 CK906137 CD673157 BM873324 BC047039 
BI962700 BQ921101 CR542133 BM927298 CR456434 CD672240 CD671455 F22774 
AF228707 F22773 CD672239 BM040848 CD368547 BF792993 AA429799 NM_005675 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DGCR6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CAGAAGAGGC
DGCR6 Expression
About this image


DGCR6 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Brain (Nervous System)    fully expand to see all 13 entries
         Thalamus
         Olfactory Bulb   
DGCR6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

DGCR6 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.474185

UniProtKB/Swiss-Prot: DGCR6_HUMAN, Q14129
Tissue specificity: Found in all tissues examined with highest expression in liver, heart and skeletal muscle.
Lower levels in pancreas and placenta. Weak expression in brain

    Custom PCR Arrays for DGCR6
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGCR6

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for DGCR6 gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Dgcr65 DiGeorge syndrome critical region gene 6   --   16 (11.19 cM) 18052860 
chicken
(Gallus gallus)
Aves DGCR61 DGCR6 homolog 78.74(n)
78.57(a)
  395907  NM_205040.1  NP_990371.1 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
64(a)
1 → many
GL343417.1(779649-782577)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.39722 Transcribed sequence with moderate similarity to protein more 72.67(n)    AL854739.2 
zebrafish
(Danio rerio)
Actinopterygii dgcr61 DiGeorge syndrome critical region gene 6 67.53(n)
65.46(a)
  403055  NM_205739.1  NP_991302.1 
fruit fly
(Drosophila melanogaster)
Insecta gdl6
gonadal
34(a)
1 → many
3L(15502545-15504147)


ENSEMBL Gene Tree for DGCR6 (if available)
TreeFam Gene Tree for DGCR6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for DGCR6 gene
LOC102724770  DGCR6L2  
1 SIMAP similar gene for DGCR6 using alignment to 5 protein entries:     DGCR6_HUMAN (see all proteins):
DGCR6L

Find genes that share paralogs with DGCR6           About GenesLikeMe


1 Pseudogenes.org Pseudogene for DGCR6
PGOHUM00000246234


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for DGCR6 (see all 255)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1895718091,2
--2513965(+) AGTGGC/TCTGAG 1 -- us2k10--------
rs1822787451,2
--2513988(+) TTATTC/TACTTT 1 -- us2k10--------
rs1391270331,2
--2513993(+) CACTTC/TATTCA 1 -- us2k10--------
rs1867602031,2
--2835125(+) TGCAAA/GTCTGA 1 -- us2k10--------
rs1454561011,2
C--2835174(+) GCTCTA/TTGGAC 1 -- us2k10--------
rs4386731,2
C,A,H--2835213(+) GCACCT/CGCCCT 1 -- us2k16Minor allele frequency- C:0.40MN NA WA CSA 194
rs1924433471,2
--2835239(+) CTTCCA/GCAGCC 1 -- us2k10--------
rs1857266291,2
--2835245(+) CAGCCG/TGGCCA 1 -- us2k10--------
rs1886496741,2
--2835294(+) CAGGGA/CCTTTG 1 -- us2k10--------
rs1424131621,2
--2835389(+) ATGGTC/TGGTGG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for DGCR6 (18893541 - 18901751 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for DGCR6 (see all 37):    About this table    
Variant IDTypeSubtypePubMed ID
nsv435744CNV Deletion17901297
dgv4827n71CNV Loss21882294
nsv914227CNV Loss21882294
dgv4826n71CNV Loss21882294
nsv459336CNV Loss19166990
nsv471180CNV Loss18288195
nsv914226CNV Loss21882294
nsv914195CNV Loss21882294
dgv542n27CNV Loss19166990
esv2751935CNV Loss17911159

Human Gene Mutation Database (HGMD): DGCR6
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing DGCR6
DNA2.0 Custom Variant and Variant Library Synthesis for DGCR6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 601279    OMIM disorders: --

2 diseases for DGCR6:    
About MalaCards
digeorge syndrome    schizophrenia

3 diseases from the University of Copenhagen DISEASES database for DGCR6:
DiGeorge syndrome     Velocardiofacial syndrome     Schizoaffective disorder

Find genes that share disorders with DGCR6           About GenesLikeMe

2 Novoseek inferred disease relationships for DGCR6 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
velo-cardio-facial syndrome 89.8 2 15821931 (1)
digeorge syndrome 89.5 8 9605865 (3), 19420922 (1), 8733130 (1), 15821931 (1)

Genetic Association Database (GAD): DGCR6
Human Genome Epidemiology (HuGE) Navigator: DGCR6 (2 documents)

Export disorders for DGCR6 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for DGCR6 gene, integrated from 10 sources (see all 18):
(articles sorted by number of sources associating them with DGCR6)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Isolation of a novel gene from the DiGeorge syndrome critical region with homology to Drosophila gdl and to human LAMC1 genes. (PubMed id 8733130)1, 2, 3, 9 Demczuk S.... Aurias A. (Hum. Mol. Genet. 1996)
  2. Biochemical characterisation of the proteins encoded by the DiGeorge critical region 6 (DGCR6) genes. (PubMed id 15821931)1, 2, 9 Pfuhl T.... Graesser F.A. (Hum. Genet. 2005)
  3. Two functional copies of the DGCR6 gene are present on human chromosome 22q11 due to a duplication of an ancestral locus. (PubMed id 11157784)1, 2, 9 Edelmann L.... Morrow B.E. (Genome Res. 2001)
  4. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (J Psychiatr Res 2010)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
  7. Dysregulation of DGCR6 and DGCR6L: psychopathological outcomes in chromosome 22q11.2 deletion syndrome. (PubMed id 22832905)1 Das Chakraborty R....Shashi V. (Transl Psychiatry 2012)
  8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  9. GABA(B) receptor subunit 1 binds to proteins affected in 22q11 deletion syndrome. (PubMed id 20036641)1 Zunner D....Kornau H.C. (Biochem. Biophys. Res. Commun. 2010)
  10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8214 HGNC: 2846 AceView: DGCR6 Ensembl:ENSG00000183628 euGenes: HUgn8214
ECgene: DGCR6 H-InvDB: DGCR6

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for DGCR6 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for DGCR6 gene:
Search GeneIP for patents involving DGCR6

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DGCR6  
 OriGene qPCR primer pairs and template standards for DGCR6   OriGene Protein Over-expression Lysate for DGCR6  
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 Block miRNA regulation of human, mouse, rat DGCR6 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DGCR6
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DGCR6 Predesigned siRNA for gene silencing in human, mouse, rat DGCR6
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 Custom PCR Arrays for DGCR6 Search Chromatin IP Primers for DGCR6
 Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat DGCR6 Search GeneGlobe Interaction Network for DGCR6
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 GenScript Custom Purified and Recombinant Proteins Services for DGCR6 GenScript cDNA clones with any tag delivered in your preferred vector for DGCR6
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 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
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 Search Tocris compounds for DGCR6
 Browse Sino Biological Proteins
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 DGCR6 antibodies
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 See all of Abcam's Antibodies, Kits and Proteins for DGCR6
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 Browse ESI BIO Cell Lines and PureStem Progenitors for DGCR6
 Gene Synthesis
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DGCR6
 SwitchGear 3'UTR luciferase reporter plasmids for DGCR6
 SwitchGear Promoter luciferase reporter plasmids for DGCR6
 ThermoFisher Antibodies for DGCR6
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DGCR6
 Browse compounds at ApexBio
 Addgene plasmids for DGCR6
  Search eBioscience for proteins for DGCR6
  Search eBioscience for elisas for DGCR6
  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for DGCR6
 antibodies-online antibodies for DGCR6 (23 products)
 antibodies-online kits for DGCR6 (6 products)
 antibodies-online peptides for DGCR6
 antibodies-online proteins for DGCR6 (5 products)
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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